Digital Commons Network^™

Metabolic Liver Cancer: Associations Of Rare And Common Germline Variants In One-Carbon Metabolism And Dna Methylation Genes, Samuel O Antwi, Michael Heckman, Launia White, Irene Yan, Vivekananda Sarangi, Kimberly P Lauer, Joseph Reddy, Fowsiyo Ahmed, Swathi Veliginti, Ellis D Mejías Febres, Rikita I Hatia, Ping Chang, Laura Izquierdo-Sanchez, Loreto Boix, Angela Rojas, Jesus M Banales, Maria Reig, Per Stål, Manuel Romero Gómez, Amit G Singal, Donghui Li, Manal M Hassan, Lewis R Roberts, Tushar Patel

Faculty, Staff and Student Publications

Animal studies implicate one-carbon metabolism and DNA methylation genes in hepatocellular carcinoma (HCC) development in the setting of metabolic perturbations. Using human samples, we investigated the associations between common and rare variants in these closely related biochemical pathways and risk for metabolic HCC development in a multicenter international study. We performed targeted exome sequencing of 64 genes among 556 metabolic HCC cases and 643 cancer-free controls with metabolic conditions. Multivariable logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for multiple comparisons. Gene-burden tests were used for rare variant associations. Analyses were performed in …

Unraveling The Serotonin Saga: From Discovery To Weight Regulation And Beyond – A Comprehensive Scientific Review, Kristine Conde, Shuzheng Fang, Yong Xu

Faculty, Staff and Students Publications

The prevalence of obesity is rapidly increasing worldwide, while the development of effective obesity therapies lags behind. Although new therapeutic targets to alleviate obesity are identified every day, and drug efficacy is improving, adverse side effects and increased health risks remain serious issues facing the weight-loss industry. Serotonin, also known as 5-HT, has been extensively studied in relation to appetite reduction and weight loss. As a result, dozens of upstream and downstream neural targets of 5-HT have been identified, revealing a multitude of neural circuits involved in mediating the anorexigenic effect of 5-HT. Despite the rise and fall of several …

Examining Factors Impacting The Service Needs Of Unhoused Women, Holly Brott

Dissertations and Theses

Women account for a sizeable proportion of the unhoused population in the U.S. Over one-third (38.7%) of unhoused individuals are women, which is a 17% increase from 2016 (United States Department of Housing and Urban Development, 2019). The increased prevalence of women experiencing homelessness calls for a renewed examination of their service needs. This dissertation presents three studies examining factors impacting the service needs of unhoused women. The first manuscript examined factors contributing to unhoused mothers’ successful completion of transitional housing; highlighted participant-identified programmatic strengths; and investigated differences in facilitators to success across two geographic contexts: one rural and one …

Drivers And Dynamics Of Phytoplankton Communities And Harmful Algal Blooms In Mountain Lakes, Lara Stephanie Jansen

Dissertations and Theses

Harmful cyanobacterial blooms (cyanoHABs) are a complex and widespread disturbance in freshwater water bodies, impacting water quality for wildlife and human populations. While cyanobacteria often bloom in warm lakes impacted by human development like agriculture, blooms are increasingly reported in cooler waters with limited development in the surrounding watershed. As much of cyanoHAB research has focused on lakes in highly developed watersheds, the understanding of factors leading to cyanobacteria dominance and blooms in the absence of major development remains limited. Mountain lakes can serve as ideal systems to study bloom-forming cyanobacteria in watersheds with minimal development. In addition, mountain lakes …

Elucidation Of Antibacterial, Synergistic, Antioxidant, And Anticancer Activities Of Green Synthesized Copper Oxide Nanoparticles Against Human Breast Cancer Cells, Ravindran Muthukumarasamy, Muhammad Luqman Bin Nisa, Nur Absarina Binti Rosli, Nurul Syazwani Binti Kamaruddin, Mohammad Danish, Afzan Binti Mahmad, M.N. Mohamad Ibrahim, Shahnaz Majeed

Karbala International Journal of Modern Science

The study conducted biosynthesis of copper oxide nanoparticles using an aqueous extract of Aspergillus niger and in-vestigated their potential biomedical applications. The nanoparticles were characterized using various techniques in-cluding UV-Vis, SEM, TEM, and EDX, revealing their spherical to crystalline shape with sizes ranging from 21 nm to 48 nm. The nanoparticles demonstrated notable antimicrobial activity against Staphylococcus aureus with a zone of 8 mm and Escherichia coli recorded high synergistic activity with 20.93%, as well as antioxidant properties. Furthermore, selective cytotoxicity towards breast cancer cells was observed with an IC50 of 107.81 ug/ml and an IC50 of 250.93 ug/ml on …

Pain In The Dying Patient, Shanna Selph

MSN Capstone Projects

This benchmark aims to educate nurses, doctors, and families on the importance of proper pain management in dying patients. The evidence in this benchmark will be appraised to improve practice, improve outcomes, and reduce healthcare costs (Melnyk, 2018). Feelings of being overwhelmed, fatigue, confusion, and guilt can occur in healthcare professionals without the proper knowledge of pain in the dying patient. Health professionals are responsible for ensuring proper care of patients is taken during the most difficult time of their lives to ensure they have the best quality of life through the end of their lives. The question to be …

Implementation Of An Evidence-Base Hospital Acquired Pressure Injury Prevention Program, Brenda Miner

MSN Capstone Projects

Covid-19 hindered many quality improvement projects. As the stressors from the pandemic began to disappear the healthcare industry was struck with new struggles. These new struggles were ensuring quality care was being provided to all patients. The decline in quality care also led to a decline in reimbursement from payor sources, such as Medicare. During the pandemic the healthcare industry was at their most vulnerable state and now that the dust is settling the ramifications of just surviving are staring the industry right in the eyes. Change is difficult, but it is even more difficult following traumatic events such as …

Safe Staffing, Safe Patients Benchmark Project, Sarah Barton

MSN Capstone Projects

With the most recent pandemic, nurses have been overworked, overwhelmed, and understaffed at dangerous levels. Nurses are leaving full time employment at this facility in droves to seek better wages through traveling. In turn, our patient outcomes have taken a large hit, with an increase in falls, pressure ulcers, and catheter-acquired urinary tract infections, to name a few. This is costly for the hospital, not to mention the damper it puts on the hospital’s vision and goals. With the implementation of a nursing incentive program, the hospital could cut overall spending in half within 2 years with an investment of …

The Need To Reconceptualize Wild Animals Post-Covid 19: Miscoordination Of Wildlife Regulations In China’S Food Legal Order, Yi Seul Kim

Pace Environmental Law Review

Today, China is one of the largest markets for wild animal trading. Yet, wild animals are in a regulatory grey area. There is an increasing need to revisit how wild animals are simultaneously but differently regulated in the food and wildlife protection regimes. Rarely do attempts to understand these two regimes occur, making this article's analysis of miscoordination in these bodies of law crucial in addressing the hindrance of nationwide food safety improvement efforts.

Gene Expression Genetics Of The Striatum Of Diversity Outbred Mice., Vivek M. Philip, Hao He, Michael C Saul, Price E Dickson, Jason A. Bubier, Elissa J Chesler

Faculty Research 2023

Brain transcriptional variation is a heritable trait that mediates complex behaviors, including addiction. Expression quantitative trait locus (eQTL) mapping reveals genomic regions harboring genetic variants that influence transcript abundance. In this study, we profiled transcript abundance in the striatum of 386 Diversity Outbred (J:DO) mice of both sexes using RNA-Seq. All mice were characterized using a behavioral battery of widely-used exploratory and risk-taking assays prior to transcriptional profiling. We performed eQTL mapping, incorporated the results into a browser-based eQTL viewer, and deposited co-expression network members in GeneWeaver. The eQTL viewer allows researchers to query specific genes to obtain allelic effect …

Proposing A Measure Of Ethicality For Humans And Ai, Alejandro Jorge Napolitano Jawerbaum

Electronic Theses and Dissertations

Smarter people or intelligent machines are able to make more accurate inferences about their environment and other agents more efficiently than less intelligent agents. Formally: ‘Intelligence measures an agent’s ability to achieve goals in a wide range of environments.’ (Legg, 2008)

In this dissertation we extend this definition to include ethical behaviour and we will offer a mathematical formalism and a way to estimate how ethical an action is or will be, both for a human and for a computer, by calculating the expected values of random variables. Formally, we propose the following measure of ethicality, which is computable, or …

Examining School Nurses' Knowledge And Confidence Related To Their Intention To Screen For And Report Child Sexual Abuse: A Descriptive Cross-Sectional Study, Suzanne Ackers

Electronic Theses and Dissertations

Background: Child sexual abuse (CSA) in a preventable national public health problem that results in adverse health consequences. Research suggests many victims are currently attending school. Screening for early detection of health issues is integral to school nurse (SN) practice but there is little evidence that screening for CSA is occurring in schools despite recommendations that it should be. Lack of confidence and knowledge related to screening for suspected CSA contribute to a SN’s missed opportunity for early intervention.

Purpose: To describe SNs knowledge and self-efficacy associated with screening for and reporting CSA in school settings.

Methods: A descriptive cross-sectional …

Improving Ostomy Patient’S Self-Efficacy And Quality Of Living Through Prehabilitation And Prevention Of Complications Using Telehealth Visits: A Quality Improvement Project, Shabnam Pratik Bagh

Doctor of Nursing Practice (DNP) Manuscripts

Due to the rise in colorectal cancer and diverticular diseases in the United States, approximately 100,000 to 150,000 intestinal stomas (fecal diversions) are created annually. With approximately 80% of readmissions experiencing post-discharge complications (Agri et al., 2020), quality improvement (QI) initiatives to increase ostomy patient’s self-efficacy and quality of living (QOL) are needed. The purpose of this QI project was to enhance the current continuum of care for ostomy patients by adding a Prehabilitation Session prior to surgery followed up with 24-hour Telehealth visits after discharge from the hospital to support their living with an ostomy. The resulting Comprehensive Ostomy …

The Impact Of Repeated Reading Intervention On Oral Reading Fluency For Students With Autism Spectrum Disorder (Asd) In Saudi Arabia, Ahmed Al Naji

Electronic Theses and Dissertations

The prevalence rate of learners with autism spectrum disorder (ASD) has risen concurrently with their inclusion into public schools in Saudi Arabia. Being in schools, they face academic challenges, particularly in reading. This increased rate evokes the importance of implementing valuable strategies to keep up the academic skills of those students. These students require Evidence-Based Practices (EBPs), which have been demonstrated crucial for their reading development. Nevertheless, limited research has been done on examining the efficacy of EBPs used to enhance the reading skills of learners with ASD, especially their Oral Reading Fluency (ORF). This study used an effective approach …

Glycerophosphocholine Is Used For Lipid And Phosphate Metabolism By Candida Albicans, Will King

Electronic Theses and Dissertations

The metabolism of phosphatidylcholine (PC), a major eukaryotic membrane lipid, has been shown to be an important aspect of pathogenesis in Candida albicans. Of note, PC turnover product, glycerophosphocholine (GPC), is abundant renal metabolite available within the host. GPC is readily imported by C. albicans, and deletion of the major GPC transporter, Git3, leads to decreased virulence in a bloodstream infection model. Here I have characterized two potential metabolic fates of internalized GPC. The first metabolic fate explored is internalized GPC can be hydrolyzed to release P_i. To determine if GPC import and subsequent metabolism impact phosphate …

Systematic Product And Process Design Of Versatile Perfluorocarbon Nanoemulsions For Elimination Of Hypoxia And Reactive Oxygen Species, Eric Lambert

Electronic Theses and Dissertations

According to a 2022 report, organs destined for transplantation are discarded 15% of the time for various reasons (Israni et al. 2022). This highlights a critical need in transplant practices. Transplant donor tissues are in need of essential nutrients, including molecular oxygen, to maintain integrity during preservation. A current trend in preservation is to perfuse the ex vivo tissue graft with nutrient-rich aqueous perfusate on a closed circuit. This practice, known as machine perfusion (MP) is limited by the absence of an oxygen-carrying component in the perfusate. Additionally, injuries to the recipient are sustained on reperfusion of the transplanted …

"Reducing Heart Failure Readmission Rates Through Implementation Of Heart Failure Diuretic", Caley Tatrn, Yvonne Weideman, Venkatraman Srinivasan

Doctor of Nursing Practice (DNP) Manuscripts

Background and significance: heart disease was the number one cause of death in the United States in 2021, with 696, 962 deaths (Leading Causes of Death, 2022). There are about 6.2 million individuals in the U.S. total with heart failure (Kilgore et al., 2017). About one-quarter of patients with heart failure are readmitted within thirty days of discharge, while one-quarter of hospital readmissions are preventable. Between 2010-2017, over seven million patients were admitted for heart failure in the United States. Eighteen percent had a readmission within thirty days and thirty-one percent had a readmission within ninety days (Khan et …

Hoping As A Transformational Imperative In Puerto Rico: A Phenomenological And Grounded Theory Study Within Colonized Space, José Luiggi-Hernández

Electronic Theses and Dissertations

As the United States continues to restrict Puerto Rico’s self-determination and imposes oppressive institutions such as the Oversight Board, the people of the archipelago live in precarity and hopelessness. Limited psychological research on colonialism has focused on the detrimental impact of oppression and its influence on the development of fatalism and the inferiority complex. On the other hand, existing psychological theories of hope fail to describe how it is lived within the post-colonial context and to explain the ways in which this psychological phenomenon arises even in the face of systematic dehumanization. As Puerto Ricans show evident signs of hope …

Temporal Transcriptomic Profiling Elucidates Sorghum Defense Mechanisms Against Sugarcane Aphids, Heena Puri, Sajjan Grover, Lise Pingault, Scott E. Sattler, Joe Louis

Department of Entomology: Faculty Publications

Background The sugarcane aphid (SCA; Melanaphis sacchari) has emerged as a key pest on sorghum in the United States that feeds from the phloem tissue, drains nutrients, and inflicts physical damage to plants. Previously, it has been shown that SCA reproduction was low and high on sorghum SC265 and SC1345 plants, respectively, compared to RTx430, an elite sorghum male parental line (reference line). In this study, we focused on identifying the defense-related genes that confer resistance to SCA at early and late time points in sorghum plants with varied levels of SCA resistance.

Results We used RNA-sequencing approach to …

Assessment Of Facultative Sulfur Reducing Bacteria In Acidic And Circumneutral Passive Remediation Systems Using A Novel Culturing Technique, Natalie Lamagna

Electronic Theses and Dissertations

Pollution resulting from abandoned mine drainage (AMD) is widespread across the nation and impacts thousands of miles of watersheds in Pennsylvania alone. AMD contaminants pose hazards to ecosystems and to human health by lowering the pH and by suspending toxic heavy metals in water. Sulfur reducing bacteria (SRB) are known to remove metals and sulfur species from mine drainage through the formation of metal sulfide precipitates and have been documented to raise the alkalinity of water. Therefore, it is necessary to understand the environmental conditions in which these microorganisms survive. Environmental samples were collected from a circumneutral and an acidic …

Vol. 52 No. 3 - Whole No. 374, Megan Abrahamson

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Why Feed Seaweed? Tacit And Codified Knowledge Networks In The Dairy Industry, Michelle K. Tynan

Theses - ALL

While demand for dairy products increases globally, dairy cattle and other ruminants emit over a quarter of total methane emissions through enteric fermentation (Carrazco et al., 2020). A potent greenhouse, methane has eighty times the global warming potential of carbon dioxide over a 20-year period (Black et. al., 2021). Consumer demand for more environmentally friendly dairy products paired with state climate goals has the dairy industry seeking ways to reduce methane emissions. One proposed solution is to feed algae (e.g., seaweed, kelp) to cows, as some live animal trials have shown it can reduce methane emissions by 80% (Stefenoni et …

“Money For Food”: A Deeper Look At Food Insecurity And Class Privilege In Higher Education, April Lopez

Theses - ALL

Assumptions around the class privilege of college students are misconstrued. Food insecurity rates among college students (between 20-50%) far outweigh the rate of food insecurity nationally (12%) (Dubick et al., 2016). With the rising cost of tuition, insufficient financial aid, and the growth of first-generation and lower income students entering higher education, an increasing number of college students are struggling to balance paying for tuition and basic needs such as food. This paper looks at how factors such as race, undergraduate year, first-generation status, and employment status impact a student’s likelihood of being food insecure. While most studies focus on …

Using Motivation To Assess Affective States Of Captive Red Kangaroos (Macropus Rufus) In Response To Visitor Presence And Crowd Size In A Walk-Through Zoo Exhibit, Julia King

Theses and Dissertations

This study investigates how visitor presence influences affective states of captive red kangaroos housed in a walk-through zoo exhibit by using motivation to consume a food reward in desired vs undesired locations and with/without an additional challenge feeder as a proxy for affective state, while considering individual variation and personality.

The Effect Of An Elephant Conservation Education Program On The Knowledge Base Of Children In Thailand, Angela Larios

Theses and Dissertations

Habitat fragmentation and human-elephant conflict (HEC) are two factors that have caused harm to both Asian elephants and humans in Thailand. Think Elephants International (TEI) is a non-profit organization whose goal is to educate children on these issues to encourage more interest in and knowledge about elephant conservation in the youth of Thailand. TEI has developed a systematic education initiative and established a method for assessing the program’s efficacy using a pre- and post-survey. The current study analyzes student responses from one open-ended question from this survey collected both before and after the students participated in the TEI program. This …

The Rise Of Mercury: The Economic And Health Impacts Of Artisanal Gold Mining In Colombia, Jilmar D. Robledo Caicedo

Theses and Dissertations

Gold prices triggered mining booms in Colombia, leading to wealth and mercury pollution. These effects on human health remain unknown. This research investigates the effect of gold mining finding a significant effect on fetal deaths reduction, suggesting gender and gestational age are fundamental to understanding the interplay of gold mining.

Characterizing Feedlot Feed Using Depth Cameras And Imaging Technology, Jean Niwenshuti

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

Imaging technology is a growing field that provides solutions in many areas from manufacturing to agriculture. Through previous research, imaging technologies have been studied in livestock farming to monitor the animal’s health and welfare in the production process. However, the feedlot industry is still behind in validating the feasibility to use some of these technologies nor to adopt such technologies to address challenges the industry is facing, such as lack of skilled labor.This work proposes using novel imaging methods to identify feed types and estimate the amount of feed remaining in a typical Midwestern feedlot feed bunk. These methods have …

Overview Of Iron Deficiency And Iron Deficiency Anemia In Women And Girls Of Reproductive Age, Richard J. Derman, Anmol Patted

Global Health Articles

Over 50% of pregnant women are anemic and the majority of these are iron deficient. Micronutrient deficiency, the symptom of heavy menstrual bleeding in nonpregnant individuals, and loss of blood associated with pregnancy and obstetric delivery contribute to iron deficiency (ID). Poor outcomes with low maternal iron can affect not only the pregnancy but can also have major bearings on the offspring. Correction of ID and iron deficiency anemia (IDA) in pregnant and prepregnant populations with single-dose intravenous iron supplementation may offer improved outcomes. A harmonization process that incorporates all major randomized controlled trials studying the use of single-dose IV …

Engaging Interprofessional Collaboration In The Implementation Of Breastfeeding Patient Education In The Prenatal Setting, Lisa Cerqua, Dawn Davison, Caitlin Dwyer, Janice E. Hobba-Glose

Creating Healthy Work Environments (CHWE)

True collaboration is a crucial component of implementing change and promoting a healthy work environment in the healthcare setting. This project highlights the significance of collaboration in implementing a standardized prenatal breastfeeding education curriculum. The outcome demonstrated successful improvement in breastfeeding initiation rates and achievement of Baby Friendly Hospital Designation.

Summer Commencement: August 4, 2023, University Of North Dakota

UND Commencement Programs

UND Summer Commencement program from August 4, 2023.