Digital Commons Network^™

[Dataset] Comparison Of Intermittent Fasting And Voluntary Wheel Running On Physical And Cognitive Abilities In High-Fat Diet-Induced Obese Rats, Chaya Gopalan, Paige Niepoetter, Carolyn Butts-Wilmsmeyer, Sai Medavaka, Avery Ogle, Sheyenne Daughrity, Elizabeth Hackmann, Saruveish Mogan, Oskar Lenz

Applied Health Faculty Research, Scholarship, and Creative Activity

Regular physical activity is a proven routine for weight management in addressing obesity. Another method that has gained attention for its health benefits is intermittent fasting (IF). Physical and cognitive abilities while on these routines are poorly understood in the obese population. Sixty-five male Sprague Dawley rats at 7 weeks of age were subjected to diet-induced obesity by feeding a high-fat diet (HFD) or a standard diet (SD) for 8 weeks, after which behavioral testing was performed to detect any changes in physical and cognitive abilities. Rats from the HFD-fed (now considered obese) and SD-fed groups were then subjected to …

Biogenic Synthesis, Spectroscopic Characterization And Bioactivity Of Cymbopogon Citratus Derived Silver Nanoparticles, Narcisse Basosila, Clément Inkoto, Ormiel Maganga, Blaise Mbembo, Giresse Kasiama, Carlos Kabengele, Clarisse Falanga, Colette Masengo, Pius Mpiana, Koto-Te-Nyiwa Ngbolua

Journal of Applied Sciences and Nanotechnology

The use of plant extracts as a bio-reducer for the synthesis of silver nanoparticles has attracted attention due to its rapid, ecological, non-toxic and economical protocol. The aim of this study was to investigate the possibility of synthesizing silver nanoparticles using Cymbopogon citratus leaf extract, and characterizing them by Ultraviolet-visible spectroscopy, X-ray Diffraction and X-ray Fluorescence in order to determine their size and composition, as well as to evaluate them in-vitro bioactivity on selected models. The results of this study show that silver nanoparticles were successfully synthesized, with a size of 29.49 nm. The silver nanoparticles showed bactericidal activity against …

Assessing Effective Communication Styles And Preferences Between Health Researchers And State Policymakers, Shelby Flores-Thorpe

Dissertations and Theses (Open Access)

This dissertation examined how health researchers and state policymakers can effectively communicate with each other to support the use of evidence-based public health information in the policymaking process. To achieve this, a systematic review, analysis of TX RPC Project data, and semi-structured interviews were conducted among health researchers and policymakers. The systematic review found that email, in-person meetings, and phone calls were the best way to reach policymaking offices at the federal and state levels. When providing policymaking offices with data, health researchers should provide briefs, summaries, fact sheets, or one-pagers to support legislative offices’ need for information. Shorter reports …

Research Nexus : Volume 6 - 2023, Office Of Research And Graduate Studies

Office of Research and Graduate Studies

• Researcher Spotlight: Dr Marleen Temmerman, Director CoEWCH
• Insights from the Bi-annual Research Townhalls
• GoalKeepers 2030: Dr Fyezah Jehan Advances Global Goals Through Innovation
• Strengthening Biosafety in Research: Insights from Dr Muhammad Zohaib
• Navigating Grant & Funding Opportunities with Funding Institutional

Editorial: Parasitism: The Good, The Bad And The Ugly, Marco A. Juarez-Estrada, Danielle Graham, Xochitl Hernandez-Velasco, Guillermo Tellez-Isaias

Poultry Science Faculty Publications and Presentations

Editorial on the Research Topic

Parasitism: the good, the bad and the ugly

Attaining The Right To Environment Through Environmental Impact Assessment, Umair Saleem

Dissertations & Theses

The thesis discusses the interconnection between the right to environment and environmental impact assessment (EIA), elaborating their depth and collective potential to effectively address most – if not all – of the complex and interconnected environmental challenges.

Firstly, the thesis explores the evolution of the environmental laws from the year 1900 and provides a unifying synthesis of the diverse environmental components, obligations, rights, and principles within international, regional, and national environmental laws. Secondly, it identifies the right to environment as a unifying and holistic right that integrates these environmental concepts and encapsulates comprehensive environmental protection. Thirdly, it provides a comparison …

Yale Medicine Magazine Autumn 2023, Issue 171, Yale University. School Of Medicine

Yale Medicine Magazine - alumni bulletin and magazine

This is the Autumn 2023 issue of Yale Medicine Magazine, issue 171. Prepared in cooperation with the alumni and development offices at the School of Medicine. Earlier volumes are called Yale School of Medicine alumni bulletins, dating from v.1 (1953) through v.13 (1965) and Yale Medicine: alumni bulletin of the School of Medicine, v.1 (1965) through v. 52, no.1. (Autumn 2017).

Ipulse: October 2023, Lynn University

Student Newspapers

Issues:

• October 2023 [Fall Week #2]: A Fresh Start for Women's Lacrosse; Let's Talk: Life as a Therapist & Lynn Alumna; Unhealthy Diets and Student-Athletes; Crafting Up TikTok; Savoring Spain: A Study Abroad Experience; Unity Engine Developers Apologize for Policy Change; To Strike or Not to Strike: That is the Question; Residence Halls at Lynn
• October 2023 [Fall Week #3]: A Professor's Passport to Academics; The Digital Marketing Perspective; Pura Vida Miami: Now in Boca Raton!; Paw-Sitive Impact: Emotional Support Animals and Mental Health; The Perfect Weekend Escape From Boca; A Ray of Hope; Trump 2.0; From Degrees to the …

How Does Nutrition, Exercise, Sleep, And Phone Addiction Affect Elementary Student Learning?, Madeline (Marston) Ballis

School of Education and Leadership Student Capstone Projects

Ballis, M. (2023). How does Nutrition, Exercise, Sleep, and Phone Addiction affect Elementary Student Learning? The research question addressed in this capstone is “How can elementary schools foster learning through the awareness of healthy lifestyle behaviors, such as nutrition, exercise, sleep, and healthy phone use in low-income students and families?” This paper follows the research of me, Madeline Ballis, a fourth grade teacher, as I discover the importance of healthy lifestyle behaviors for elementary students, specifically those from low socioeconomic status (SES) families. The research was inspired by my past experience in studying psychology and personal experience with each of …

Moderate Heat Stress-Induced Sterility Is Due To Motility Defects And Reduced Mating Drive In Caenorhabditis Elegans Males, Nicholas B. Sepulveda, Donald Chen, Lisa N. Petrella

Biological Sciences Faculty Research and Publications

Moderate heat stress negatively impacts fertility in sexually reproducing organisms at sublethal temperatures. These moderate heat stress effects are typically more pronounced in males. In some species, sperm production, quality and motility are the primary cause of male infertility during moderate heat stress. However, this is not the case in the model nematode Caenorhabditis elegans, where changes in mating behavior are the primary cause of fertility loss. We report that heat-stressed C. elegans males are more motivated to locate and remain on food and less motivated to leave food to find and mate with hermaphrodites than their unstressed counterparts. …

Rooted In Grant County, Jenna Gerig

Public Relations Student Projects

Because the goal of this campaign is to promote Grant County assets, initial research sought to assess communication throughout the county, gather insight on the impact of churches, and accumulate information on how to best retain its college students. Research also sought to identify the personas of Grant County residents to discover their values and beliefs. Additional research helped determine the most appealing assets, including churches and nonprofits, universities, parks and venues, events, and affordable living. Additionally, a survey was conducted to understand why students who attend colleges in Grant County choose to leave the county upon graduation.

Application Of The Social Determinants Of Health To Geriatric Patients By Nurse Practitioner Students, Theresa Marie Gruenke Schnable

Dissertations (1934 -)

ABSTRACT APPLICATION OF THE SOCIAL DETERMINANTS OF HEALTH TO GERIATRIC PATIENTS BY NURSE PRACTITIONER STUDENTS Patient outcomes are influenced by the social determinants of health (SDOH), which influence differing exposures to opportunities or health risks. Holistic care of geriatric patients includes considering SDOH in patient assessment, diagnosis, and care delivery. Understanding how NP students care for geriatric patients using a SDOH lens provides insight into their practice behaviors and helps educators understand how to strengthen NP programs to achieve better patient outcomes and advance health equity for the geriatric population. The purpose of this study was to describe how NP …

Teaching And Tomorrow: Children's Mercy Hospital Pediatric Gastroenterology Fellowship Program, Children's Mercy Kansas City

Posters

No abstract provided.

The New Miracle “Meat”: The Future Food Industry’S Approach To Young Jackfruits, Minh Tran Ha

The Synapse: Intercollegiate science magazine

No abstract provided.

Issue 37

The Synapse: Intercollegiate science magazine

No abstract provided.

Pengembangan Sistem Informasi Desa Dalam Upaya Penanggulangan Kemiskinan Di Desa Rarang Selatan, Meita Annisa, Bambang Shergi Laksmono

Jurnal Ilmu Kesejahteraan Sosial

Indonesia continues to face challenges in poverty alleviation, with extreme poverty still prevalent in the country. Despite having a social protection system aimed at reducing poverty and cushioning the poor and vulnerable from crises, its implementation often encounters difficulties, particularly in obtaining valid and verified data sources. This study explores how the development of the Village Information System (SID) can contribute to poverty alleviation in Rarang Selatan Village, West Nusa Tenggara Province (NTB). When SID was introduced in 2016, Rarang Selatan was a newly established village classified as underdeveloped. By 2022, the village had progressed to the category of an …

Epanorama October 2023, Southern Adventist University

Panorama Parent Newsletter

This electronic issue of Panorama includes information on the new Freshman class and the new Business building.

Short-Term Biomarker Modulation Study Of Dasatinib For Estrogen Receptor-Negative Breast Cancer Chemoprevention, Fatma Nihan Akkoc Mustafayev, Diane D Liu, Angelica M Gutierrez, John E Lewis, Nuhad K Ibrahim, Vicente Valero, Daniel J Booser, Jennifer K Litton, Kimberly Koenig, Dihua Yu, Nour Sneige, Banu K Arun

Faculty, Staff and Student Publications

OBJECTIVE: Risk-reducing therapy with selective estrogen receptor (ER) modulators and aromatase inhibitors reduce breast cancer risk. However, the effects are limited to ER-positive breast cancer. Therefore, new agents with improved toxicity profiles that reduce the risk in ER-negative breast cancers are urgently needed. The aim of this prospective, short-term, prevention study was to evaluate the effect of dasatinib, an inhibitor of the tyrosine kinase Src, on biomarkers in normal (but increased risk) breast tissue and serum of women at high risk for a second, contralateral primary breast cancer.

MATERIALS AND METHODS: Women with a history of unilateral stage I, II, …

Coordinated School Health 2022-23 Annual Report, Tennessee. Department Of Education.

Coordinated School Health

No abstract provided.

Human Intestinal Organoids As Models To Study Enteric Bacteria And Viruses, Grace Adeniyi-Ipadeola, Hephzibah Nwanosike, Sasirekha Ramani

Faculty, Staff and Students Publications

Laboratory studies of host-microbe interactions have historically been carried out using transformed cell lines and animal models. Although much has been learned from these models, recent advances in the development of multicellular, physiologically active, human intestinal organoid (HIO) cultures are allowing unprecedented discoveries of host-microbe interactions. Here, we review recent literature using HIOs as models to investigate the pathogenesis of clinically important enteric bacteria and viruses and study commensal intestinal microbes. We also discuss limitations of current HIO culture systems and how technical advances and innovative engineering approaches are providing new directions to improve the model. The studies discussed here …

Regulation Of Tumor Apoptosis Of Poriae Cutis-Derived Lanostane Triterpenes By Akt/Pi3k And Mapk Signaling Pathways In Vitro, Shuai Yue, Xi Feng, Yousheng Cai, Salam A. Ibrahim, Ying Liu, Wen Huang

Faculty Research, Scholarly, and Creative Activity

Poria cocos is traditionally used as both food and medicine. Triterpenoids in Poria cocos have a wide range of pharmacological activities, such as diuretic, sedative and tonic properties. In this study, the anti-tumor activities of poricoic acid A (PAA) and poricoic acid B (PAB), purified by high-speed counter-current chromatography, as well as their mechanisms and signaling pathways, were investigated using a HepG2 cell model. After treatment with PAA and PAB on HepG2 cells, the apoptosis was obviously increased (p < 0.05), and the cell cycle arrested in the G2/M phase. Studies showed that PAA and PAB can also inhibit the occurrence and development of tumor cells by stimulating the generation of ROS in tumor cells and inhibiting tumor migration and invasion. Combined Polymerase Chain Reaction and computer simulation of molecular docking were employed to explore the mechanism of tumor proliferation inhibition by PAA and PAB. By interfering with phosphatidylinositol-3-kinase/protein kinase B, Mitogen-activated protein kinases and p53 signaling pathways; and further affecting the expression of downstream caspases; matrix metalloproteinase family, cyclin-dependent kinase -cyclin, Intercellular adhesion molecules-1, Vascular Cell Adhesion Molecule-1 and Cyclooxygenase -2, may be responsible for their anti-tumor activity. Overall, the results suggested that PAA and PAB induced apoptosis, halted the cell cycle, and inhibited tumor migration and invasion through multi-pathway interactions, which may serve as a potential therapeutic agent against cancer.

Nutritional Knowledge, Attitudes, And Practices Among Family Physician Practitioners In Gulf Countries (Bahrain, Kuwait, Saudi Arabia, And Uae), Abeer S. Alzaben, Abeer A. Aljahdali, Lulua F. Alasousi, Ghadeer Alzaben, Lynne Kennedy, Anwar Alhashem

All Works

Family physicians serve as pivotal points of contact within global healthcare systems. Nutrition plays a significant role in lifestyle and preventive medicine. With the rise of chronic and non-communicable diseases in Gulf Cooperation Council (GCC) countries, these physicians advise patients and the public on diet-related conditions. This descriptive cross-sectional study assessed the nutritional knowledge and practices across the GCC. Combining survey data from multiple GCC sites, a sample of family physicians was generated. Registered GCC family physicians received email invitations containing participant information, informed consent forms, and a self-administered online questionnaire. Analysis of data from four GCC countries involving 8751 …

Understanding The Prevalence, Progression, And Management Of Metabolic Syndrome In Saudi Arabia, Faez Falah Alshehri

Saudi Medical Journal

Metabolic syndrome (MetS) is characterized by the coexistence of several disorders comprising hypertension, abdominal obesity, insulin sensitivity, and dyslipidemia. In recent times, MetS has gained increased attention due to the global prevalence of obesity. Adipose tissue plays a crucial role in this syndrome by releasing various molecules significantly affecting lipid/insulin regulation, oxidative stress, and cardiovascular function. Tumor necrosis factor-α (p-α), an inflammatory cytokine, and adiponectin, an adipose tissue-specific protein, are considered vital adipokines that play a significant role in the pathogenesis of MetS. The impact of dietary ingredients on MetS management has been extensively studied over the past few decades. …

Food And Mood: Investigating The Correlation Between Vitamin B12 Intake And Depression, Jana Soucar, Hawley Almstedt

Health and Human Sciences Faculty Works

Vitamin B12 is an essential nutrient that metabolizes homocysteine, which is a potentially neurotoxic molecule when in excess. Studies show that a deficiency in vitamin B12, as well as folate, may be associated with mental health conditions. Additionally, the prevalence of depression is higher in college students than other demographic populations. PURPOSE: The purpose of this study was to investigate a correlation between vitamin B12 and folate intake with signs and symptoms of depression in college students. METHODS: This study was conducted by first providing participants with the Beck Depression Inventory (BDI) to measure signs and symptoms of …

A Blunted Th17 Cytokine Signature In Women With Mild Cognitive Impairment: Insights From Inflammatory Profiling Of A Community-Based Cohort Of Older Adults, Adam D. Bachstetter, Jenny Lutshumba, Edric D. Winford, Erin L. Abner, Barbra J. Martin, Jordan P. Harp, Linda J. Van Eldik, Frederick A. Schmitt, Donna M. Wilcock, Ann M. Stowe, Gregory A. Jicha, Barbara S. Nikolajczyk

Markey Cancer Center Faculty Publications

People with dementia have an increase in brain inflammation, caused in part by innate and adaptive immune cells. However, it remains unknown whether dementia-associated diseases alter neuro-immune reflex arcs to impact the systemic immune system. We examined peripheral immune cells from a community-based cohort of older adults to test if systemic inflammatory cytokine signatures associated with early stages of cognitive impairment. Human peripheral blood mononuclear cells were cultured with monocyte or T-cell-targeted stimuli, and multiplex assays quantitated cytokines in the conditioned media. Following T-cell-targeted stimulation, cells from women with cognitive impairment produced lower amounts of TH17 cytokines compared with cells …

Control Of Cd4+ T Cells To Restrain Inflammatory Diseases Via Eukaryotic Elongation Factor 2 Kinase, Hao-Yun Peng, Liqing Wang, Jugal Kishore Das, Anil Kumar, Darby J. Ballard, Yijie Ren, Xiaofeng Xiong, Paul De Figueiredo, Jin-Ming Yang, Jianxun Song

Markey Cancer Center Faculty Publications

CD4+ T cells, particularly IL-17-secreting helper CD4+ T cells, play a central role in the inflammatory processes underlying autoimmune disorders. Eukaryotic Elongation Factor 2 Kinase (eEF2K) is pivotal in CD8+ T cells and has important implications in vascular dysfunction and inflammation-related diseases such as hypertension. However, its specific immunological role in CD4+ T cell activities and related inflammatory diseases remains elusive. Our investigation has uncovered that the deficiency of eEF2K disrupts the survival and proliferation of CD4+ T cells, impairs their ability to secrete cytokines. Notably, this dysregulation leads to heightened production of pro-inflammatory cytokine IL-17, fosters a pro-inflammatory microenvironment …

Elongation Of Very Long Chain Fatty Acids-3 (Elovl3) Is Activated By Zhx2 And Is A Regulator Of Cell Cycle Progression, Kate Townsend Creasy, Hui Ren, Jieyun Jiang, Martha L. Peterson, Brett T. Spear

Markey Cancer Center Faculty Publications

Zinc fingers and homeoboxes 2 (Zhx2) are transcriptional regulators of liver gene expression with key functions in embryonic development as well as tissue regeneration in response to damage and disease, presumably through its control of target genes. Previous microarray data suggested that elongation of very long chain fatty acids-3 (Elovl3), a member of the ELOVL family of enzymes that synthesize very long chain fatty acids (VLCFAs), is a putative Zhx2 target gene. VLCFAs are core component of ceramides and other bioactive sphingolipids that are often dysregulated in diseases and regulate key cellular processes including proliferation. Since several previously identified Zhx2 …

Stat3 Modulates Cd4+ T Mitochondrial Dynamics And Function In Aging, Emelia Zukowski, Marco Sannella, Jack Donato Rockhold, Gabriella Kalantar, Jingting Yu, Sara Santacruz-Calvo, Madison K. Kuhn, Nasun Hah, Ling Ouyang, Tzu-Wen Wang, Lyanne Murphy, Heather Marszalkowski, Kaleigh Gibney, Micah J. Drummond, Elizabeth A. Proctor, Hatice Hasturk, Barbara S. Nikolajczyk, Leena P. Bharath

Markey Cancer Center Faculty Publications

Aging promotes numerous intracellular changes in T cells that impact their effector function. Our data show that aging promotes an increase in the localization of STAT3 to the mitochondria (mitoSTAT3), which promotes changes in mitochondrial dynamics and function and T-cell cytokine production. Mechanistically, mitoSTAT3 increased the activity of aging T-cell mitochondria by increasing complex II. Limiting mitoSTAT3 using a mitochondria-targeted STAT3 inhibitor, Mtcur-1 lowered complex II activity, prevented age-induced changes in mitochondrial dynamics and function, and reduced Th17 inflammation. Exogenous expression of a constitutively phosphorylated form of STAT3 in T cells from young adults mimicked changes in mitochondrial dynamics and …

Revolting Motherhood: [De]Generative Breast Stories Transmuting Medical/Moral Paradigms In Britain During The Long Nineteenth Century, Leslie Rene Pearson

Theses and Dissertations

Eric Plemons writes in *The Look of A Woman* that “biological stories do more than describe biologies” (54). This dissertation explores what breast cancer stories do and how society creates meaning around the experience of breast cancer. I argue that, in the long nineteenth century in Britain, breast cancer was part of a two-sided medical/moral paradigm where medical diagnosis became enmeshed with morality. Health, then, became a result of proper domestic behavior, disease a result of straying from societal norms. Following the introductory chapter, chapter two traces the development of this paradigm as an outgrowth of the emergence of middle-class …

Latency Time From Prior Authorization Submission To Initiation Of Biologic Therapy In Inflammatory Bowel Disease, Shannon Capraro, Janelle R. Noel-Macdonnell Phd, Lauren Disselhoff, Layne Sieve, Rachel Chevalier

Posters

Background For pediatric patients with a diagnosis of inflammatory bowel disease (IBD), initiation of biologic therapy can be essential to attain disease control. Unfortunately, patients often experience delays in receiving the first dose of these medications due to the need for insurance companies to approve medication prior authorizations (PA). Physicians and support staff spend many working hours collating and transferring information regarding urgency to payors. To our knowledge, no studies exist to evaluate the factors that contribute to how quickly a medication is approved in pediatric patients. We set out here to evaluate which demographic and disease factors contribute to …