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2023

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Documenting Working Experiences Of Agricultural Workers In California, Alvaro Medel-Herrero, Natalia Deeb-Sossa, Monica Torreiro-Casal, Martha Shumway, Joseph D. Hovey, Rosemary Sokas Oct 2023

Documenting Working Experiences Of Agricultural Workers In California, Alvaro Medel-Herrero, Natalia Deeb-Sossa, Monica Torreiro-Casal, Martha Shumway, Joseph D. Hovey, Rosemary Sokas

Psychological Science Faculty Publications

Over 800,000 Latina/o agricultural workers are employed in California every year, of whom approximately 400,000 are estimated to be undocumented immigrants. We convened 19 focus groups (FG) between July 2019 and January 2020 in various regions of California to gather information from Latina/o agricultural workers on social stressors. The participants’ narratives focused extensively on working conditions. This paper analyses these narratives and examines working and living conditions, as well as the combined effect of profound deprivations within most significant social domains. Agricultural workers in California characterise their working conditions as little better than slave labour. Systematic abusive practices and exploitation, …


Mga-Seq: Robust Identification Of Extrachromosomal Dna And Genetic Variants Using Multiple Genetic Abnormality Sequencing, Da Lin, Yanyan Zou, Xinyu Li, Jinyue Wang, Qin Xiao, Xiaochen Gao, Fei Lin, Ningyuan Zhang, Ming Jiao, Yu Guo, Zhaowei Teng, Shiyi Li, Yongchang Wei, Fuling Zhou, Rong Yin, Siheng Zhang, Lingyu Xing, Weize Xu, Xiaofeng Wu, Bing Yang, Ke Xiao, Chengchao Wu, Yingfeng Tao, Xiaoqing Yang, Jing Zhang, Sheng Hu, Shuang Dong, Xiaoyu Li, Shengwei Ye, Zhidan Hong, Yihang Pan, Yuqin Yang, Haixiang Sun, Gang Cao Oct 2023

Mga-Seq: Robust Identification Of Extrachromosomal Dna And Genetic Variants Using Multiple Genetic Abnormality Sequencing, Da Lin, Yanyan Zou, Xinyu Li, Jinyue Wang, Qin Xiao, Xiaochen Gao, Fei Lin, Ningyuan Zhang, Ming Jiao, Yu Guo, Zhaowei Teng, Shiyi Li, Yongchang Wei, Fuling Zhou, Rong Yin, Siheng Zhang, Lingyu Xing, Weize Xu, Xiaofeng Wu, Bing Yang, Ke Xiao, Chengchao Wu, Yingfeng Tao, Xiaoqing Yang, Jing Zhang, Sheng Hu, Shuang Dong, Xiaoyu Li, Shengwei Ye, Zhidan Hong, Yihang Pan, Yuqin Yang, Haixiang Sun, Gang Cao

Children’s Nutrition Research Center Staff Publications

Genomic abnormalities are strongly associated with cancer and infertility. In this study, we develop a simple and efficient method - multiple genetic abnormality sequencing (MGA-Seq) - to simultaneously detect structural variation, copy number variation, single-nucleotide polymorphism, homogeneously staining regions, and extrachromosomal DNA (ecDNA) from a single tube. MGA-Seq directly sequences proximity-ligated genomic fragments, yielding a dataset with concurrent genome three-dimensional and whole-genome sequencing information, enabling approximate localization of genomic structural variations and facilitating breakpoint identification. Additionally, by utilizing MGA-Seq, we map focal amplification and oncogene coamplification, thus facilitating the exploration of ecDNA's transcriptional regulatory function.


Recent Advances In The Synthesis And Antioxidant Activity Of Low Molecular Mass Organoselenium Molecules, João M Anghinoni, Paloma T Birmann, Marcia J Da Rocha, Caroline S Gomes, Michael J Davies, César A Brüning, Lucielli Savegnago, Eder J Lenardão Oct 2023

Recent Advances In The Synthesis And Antioxidant Activity Of Low Molecular Mass Organoselenium Molecules, João M Anghinoni, Paloma T Birmann, Marcia J Da Rocha, Caroline S Gomes, Michael J Davies, César A Brüning, Lucielli Savegnago, Eder J Lenardão

Faculty, Staff and Student Publications

Selenium is an essential trace element in living organisms, and is present in selenoenzymes with antioxidant activity, like glutathione peroxidase (GPx) and thioredoxin reductase (TrxR). The search for small selenium-containing molecules that mimic selenoenzymes is a strong field of research in organic and medicinal chemistry. In this review, we review the synthesis and bioassays of new and known organoselenium compounds with antioxidant activity, covering the last five years. A detailed description of the synthetic procedures and the performed in vitro and in vivo bioassays is presented, highlighting the most active compounds in each series.


Peer Influence As The Dominant Factor In Coffee Drink Consumption Among Non-Health Major University Of Indonesia Students In 2023, Patrisha Ramadhiani, Triyanti Triyanti, Sandra Fikawati Oct 2023

Peer Influence As The Dominant Factor In Coffee Drink Consumption Among Non-Health Major University Of Indonesia Students In 2023, Patrisha Ramadhiani, Triyanti Triyanti, Sandra Fikawati

Indonesian Journal of Public Health Nutrition (IJPHN)

Coffee drinks are sugar-sweetened beverages made from coffee powder, sugar, and water through heating. High consumption of coffee drinks is associated with sugar content, which can increase the risk of obesity. The aim of this study was to determine the differences in coffee drink consumption levels based on individual characteristics and environmental factors among non-health undergraduate students at the University of Indonesia in 2023. This quantitative study used a cross-sectional design with a sample of 181 active undergraduate non-health students in 2023. Data were collected in June 2023 through a self-administered questionnaire. The results showed that 52.5% of the respondents …


The Differences In Nutritional Status Based On The Use Of Online Food Delivery (Ofd) Services Among The Universitas Indonesia’S Non-Health Science Cluster Students In 2023, Muhammad Aulia Rizky, Asih Setiarini, Sandra Fikawati, Fajrinayanti Fajrinayanti Oct 2023

The Differences In Nutritional Status Based On The Use Of Online Food Delivery (Ofd) Services Among The Universitas Indonesia’S Non-Health Science Cluster Students In 2023, Muhammad Aulia Rizky, Asih Setiarini, Sandra Fikawati, Fajrinayanti Fajrinayanti

Indonesian Journal of Public Health Nutrition (IJPHN)

Uncontrolled use of Online Food Delivery (OFD) can increase food intake and affect the incidence of overweight/obesity. This study aims to examine the differences in the proportion of nutritional status based on the use of OFD services among UI non-health science cluster students. This study involved 136 respondents using a purposive sampling method and cross-sectional study design. Data were collected through anthropometric measurements, Google Form, and direct interviews to be analyzed by Chi-Square test and multiple logistic regression. The results showed significant differences in the proportion of nutritional status based on the duration of consumer loyalty, pocket money, and energy …


The Difference Of Ultra-Processed Food Consumption Based On Individual Characteristics And Other Factors Among Non-Health Undergraduate Students In Universitas Indonesia In 2023, Adeline Vashtianada, Asih Setiarini, Ratu Ayu Dewi Sartika Oct 2023

The Difference Of Ultra-Processed Food Consumption Based On Individual Characteristics And Other Factors Among Non-Health Undergraduate Students In Universitas Indonesia In 2023, Adeline Vashtianada, Asih Setiarini, Ratu Ayu Dewi Sartika

Indonesian Journal of Public Health Nutrition (IJPHN)

Ultra-processed food/UPF is a product that undergoes a series of industrial techniques and processes, also has low nutritional value. Overconsumption of UPF can increase the risk of overweight and obesity. The purpose of this study is to determine the differences in the proportion of UPF consumption based on individual characteristics, environmental factors, and lifestyle factors among non-health undergraduate students in Universitas Indonesia in 2023. A cross sectional study design conducted on 149 samples. The data was collected using a self-administered online questionnaire. The data was analyzed using univariate and bivariate (chi-square) analyses. The results showed that 50.3% of the students …


Sugary Food And Beverages Consumption, Family History, And Primary Dysmenorrhea In Undergraduate Students, Faculty Of Public Health, Universitas Indonesia, Raihani Ramadhan, Wahyu Kurnia Yusrin Putra, Diah Mulyawati Utari, Khoirul Anwar Oct 2023

Sugary Food And Beverages Consumption, Family History, And Primary Dysmenorrhea In Undergraduate Students, Faculty Of Public Health, Universitas Indonesia, Raihani Ramadhan, Wahyu Kurnia Yusrin Putra, Diah Mulyawati Utari, Khoirul Anwar

Indonesian Journal of Public Health Nutrition (IJPHN)

Primary dysmenorrhea is the most common gynecological problem experienced by women of reproductive age and can interfere with daily activities. Therefore, the aim of this study was to determine the prevalence and differences in the proportion of primary dysmenorrhea based on individual factors (duration of menstrual bleeding, family history, physical activity, stress) and diet (breakfast habits, frequency of saturated fat consumption, omega-3 consumption, iron consumption, frequency of consumption of dairy products, caffeine consumption, and frequency of consumption of sugary foods and beverages). This study used a cross-sectional design and involved 150 regular undergraduate students in the 2019-2022 batch of the …


Nutrition, Allergenicity And Physicochemical Qualities Of Food-Grade Protein Extracts From Nannochloropsis Oculata, Sara Hamzelou, Damien Belobrajdic, Angéla Juhász, Henri Brook, Utpal Bose, Michelle L. Colgrave, James A. Broadbent Oct 2023

Nutrition, Allergenicity And Physicochemical Qualities Of Food-Grade Protein Extracts From Nannochloropsis Oculata, Sara Hamzelou, Damien Belobrajdic, Angéla Juhász, Henri Brook, Utpal Bose, Michelle L. Colgrave, James A. Broadbent

Research outputs 2022 to 2026

Microalgae offer an opportunity to act as a sustainable source of dietary protein. This study aimed to evaluate the impact of different protein extraction methods on the nutritional and physicochemical properties of Nannochloropsis oculata. Food-grade protein extracts were obtained by hypotonic osmotic shock using milli-Q water. Food grade (FG) and non-food grade (NFG) extraction buffers were compared along with three cell disruption methods including bead beating, probe sonication and a combination of both methods for protein extraction. Mass spectrometry was used for protein and putative allergen identification in FG extracts. Bead beating led to a slightly higher number of identifiable …


Challenges Faced By Pregnant Women In Information-Seeking In The Tamale Metropolis, Joana Dango, Stephen Okyere Oct 2023

Challenges Faced By Pregnant Women In Information-Seeking In The Tamale Metropolis, Joana Dango, Stephen Okyere

Library Philosophy and Practice (e-journal)

The study explored the stages of pregnancy at which pregnant women seek information from various sources and the challenges pregnant women encounter in seeking information. A Mixed-method approach was used to carry out the study. A questionnaire was used to collect data from 148 pregnant women from three hospitals namely, Tamale Teaching Hospital, Tamale West Hospital, and the Seventh Day Adventist Hospital, Interviews were conducted with three midwives, one from each hospital, and a Gynecologist at the Tamale Teaching Hospital. The findings of the study revealed that the main challenges that were identified include lack of funds, non-use of the …


A Framework For Transparency In Precision Livestock Farming, Kevin C. Elliott, Ian Werkheiser Oct 2023

A Framework For Transparency In Precision Livestock Farming, Kevin C. Elliott, Ian Werkheiser

Philosophy Faculty Publications

Simple Summary

The emergence of precision livestock farming (PLF) raises important issues for many different social groups, including farmers, consumers, regulators, and the food industry. This paper explores how those who develop PLF systems can communicate more effectively with different groups about the technologies that they are creating. We suggest that developers reflect on four issues: (1) the different kinds of information that various groups might want to know; (2) the audiences that might care about these different kinds of information; (3) the major difficulties involved in providing the information; and (4) potential strategies for overcoming those difficulties.

Abstract

As …


A Global Exchange: Colsa Summer Scholars Engage In Ag Sciences, Nicholas Gosling Oct 2023

A Global Exchange: Colsa Summer Scholars Engage In Ag Sciences, Nicholas Gosling

UNH Today Archive

No abstract provided.


Integrated Pest Management And Behavior Of Stored Grain Beetles, Ethan Doherty Oct 2023

Integrated Pest Management And Behavior Of Stored Grain Beetles, Ethan Doherty

LSU Doctoral Dissertations

The lesser grain borer, Rhyzopertha dominica, and the rice weevil, Sitophilus oryzae, are two of the most destructive pests of stored rice. Their management has relied heavily upon fumigant insecticides. However, amid growing concerns that fumigant-resistant pests are becoming widespread, there is an urgent need for diversified management techniques and integrated pest management. Here, we explored management techniques and the behavior of these beetles. Host plant resistance toward both beetles was evaluated for 13 varieties of rice. We found large differences among varieties for both beetles in all resistance measures. We found that while nutritional components of a …


Engagement With Engager: What Factors Are Associated With Attendance In A Complex Intervention For Men With Common Mental Health Problems, Near To And After Release From Prison, Charlotte Lennox, Stuart G. Spicer, Sarah Leonard, Richard Byng Oct 2023

Engagement With Engager: What Factors Are Associated With Attendance In A Complex Intervention For Men With Common Mental Health Problems, Near To And After Release From Prison, Charlotte Lennox, Stuart G. Spicer, Sarah Leonard, Richard Byng

Peninsula Medical School

Engager is a complex, collaborative, but flexible intervention providing psychological and practical support to male prison leavers with sentences of two years or less. Engager was not shown to be effective from an evaluation of standard outcome measures, although full delivery of the intervention was also not achieved. The success of interventions relies partly on how able individuals are to attend, so we used an exploratory analysis of the Engager evaluation data to investigate what factors impacted on the extent to which participants attended Engager sessions. The results showed that problems with alcohol at baseline have a positive relationship with …


Information Needs And Sources For Health-Related Information Among Pregnant Women In Tamale Metropolis, Joana Dango, Stephen Okyere Oct 2023

Information Needs And Sources For Health-Related Information Among Pregnant Women In Tamale Metropolis, Joana Dango, Stephen Okyere

Library Philosophy and Practice (e-journal)

The purpose of the study is to explore the information needs and sources for health-related information among pregnant women in Tamale Metropolis. A Mixed method approach was used to carry out the study. A questionnaire was used to collect data from 148 pregnant women from three hospitals namely, Tamale Teaching Hospital, Tamale West Hospital and the Seventh Day Adventist Hospital, interviews were conducted with three midwives, one from each hospital and a Gynecologist at the Tamale Teaching Hospital. The findings of the study revealed that antenatal lessons were the most used sources of health information, and the least were newspapers …


12th International Conference On Business, Technology And Innovation 2023, University For Business And Technology - Ubt Oct 2023

12th International Conference On Business, Technology And Innovation 2023, University For Business And Technology - Ubt

UBT International Conference

Welcome to IC – UBT 2023

UBT Annual International Conference is the 12th international interdisciplinary peer reviewed conference which publishes works of the scientists as well as practitioners in the area where UBT is active in Education, Research and Development. The UBT aims to implement an integrated strategy to establish itself as an internationally competitive, research-intensive university, committed to the transfer of knowledge and the provision of a world-class education to the most talented students from all background. The main perspective of the conference is to connect the scientists and practitioners from different disciplines in the same place and make …


Fabrication Of Upper Complete Denture Combining Dental Base Materials To Cover Torus Palatinus - Case Report, Vlora Berisha Oct 2023

Fabrication Of Upper Complete Denture Combining Dental Base Materials To Cover Torus Palatinus - Case Report, Vlora Berisha

UBT International Conference

Torus palatinus provides a challenge when restoring an edentulous arch. Because the mucosa is often quite thin, tori may be sensitive to the pressure that comes from a denture basis. . A strong palatal seal is prevented by the tori's propensity for having deep undercuts that occasionally extend to the junction with the soft palate.

Case Report: A 70-year-old edentulous female came to our dental clinic, with a chief complaint of the instability of her maxillary complete dentures, and she requested new denture. The patient had been wearing the dentures for approximately 2 years. Based on the intraoral examination, the …


Oral Health In Patients With Chronic Renal Failure, L Asllani, A Мinovska, M Petrovski, M Barani Oct 2023

Oral Health In Patients With Chronic Renal Failure, L Asllani, A Мinovska, M Petrovski, M Barani

UBT International Conference

Kidneys are visceral organs that are responsible for numerous body functions. About 90% of patients with kidney failure show oral signs and symptoms on both soft and hard dental tissues, some of them are caused by the disease, while others may be caused by the treatment.

The main aim of this paper was to present the oral health changes caused by chronic renal failure.

In order to realize the main aim, adequate literature review was conducted.

The occurrence of gingival hyperplasia due to immunosuppressive therapy is the most studied oral manifestation. It is estimated that 30% of patients who are …


Consumer Perception And The Environmental Impact Of Fast-Food Packaging, Azra Nuhija, Violeta Lajqi Oct 2023

Consumer Perception And The Environmental Impact Of Fast-Food Packaging, Azra Nuhija, Violeta Lajqi

UBT International Conference

Fast food packaging represents a pervasive yet often overlooked facet of modern dining, bearing both convenience and significant environmental challenges. This study investigates how consumer awareness of the environmental consequences of packaging materials influences their preferences and behaviors. It explores consumer preferences for materials perceived as more eco-friendly, such as paper-based options over plastics, and the consequential impact on disposal practices. This study used quantitative research to investigate consumer perception and the environmental impact of fast-food packaging. It was conducted through a Google Docs survey, to which approximately 250 people responded in Kosovo. The data tool used to analyze the …


Oral Habits Of Patients As Indicators Of Occlusal Dysfunction: A Comprehensive Review, Dugagjin Sokoli, Burim Kiseri, Genc Demjaha, Vlora Berisha, Teuta Komoni, Arta Gjikolli Oct 2023

Oral Habits Of Patients As Indicators Of Occlusal Dysfunction: A Comprehensive Review, Dugagjin Sokoli, Burim Kiseri, Genc Demjaha, Vlora Berisha, Teuta Komoni, Arta Gjikolli

UBT International Conference

This research paper provides a comprehensive discussion on the pivotal role of patient habits as indicators of occlusal dysfunction. The reviewed resources collectively underscore the significance of habits such as bruxism, dietary choices, oral piercings, stress-induced behaviors, and tongue thrusting influencing occlusion and oral health. Understanding the intricate interplay between these habits and occlusal function is vital for early diagnosis, prevention, and effective management of occlusal problems.

The findings strongly advocate for proactive measures in recognizing and addressing these habits, as they can have far-reaching consequences on oral health and occlusion. Early diagnosis and tailored interventions are emphasized as essential …


The Influence Of Ecological Packaging Design On Consumer Perception Of Purchasing Food Products: A Case Study In Ulqin, Violeta Lajqi, A Ljukovic, S Dinaj, Sami Makolli Oct 2023

The Influence Of Ecological Packaging Design On Consumer Perception Of Purchasing Food Products: A Case Study In Ulqin, Violeta Lajqi, A Ljukovic, S Dinaj, Sami Makolli

UBT International Conference

Due to environmental problems from food packaging, in recent times the tendency to use different techniques for environmental protection and reducing waste from packaging has increased significantly. The main purpose of this paper is to research and assess the impact of the design of ecological packaging as a method for reducing waste from food packaging, and the impact of the ecological packaging design on consumers’ perception of purchasing food products. The research was developed in the form of a review of other researchers as well as through a survey by Google Docs., in Montenegro. The study included 300 people who …


Concerns About The High Content Of Acrylamides In Food: A Comprehensive Review, Violeta Lajqi, Pajtim Bytyçi, Mergim Mestani, Blend Broqi Oct 2023

Concerns About The High Content Of Acrylamides In Food: A Comprehensive Review, Violeta Lajqi, Pajtim Bytyçi, Mergim Mestani, Blend Broqi

UBT International Conference

Acrylamide's presence in food has recently drawn considerable interest on a global scale. One of the antecedents of acrylamide is asparagine, an amino acid that is frequently present in both plant and animal proteins. Acrylamide is listed as a potential cause of cancer, abnormal birth outcomes, and nerve damage in people. It appears naturally in foods that have been heated to high degrees as a synthetic chemical. Acrylamide is generally associated to the Millard reaction, which is prevalent in foods that mostly contain asparagine and starch, and forms during high-temperature cooking such as frying, roasting, and baking. According to the …


The Impact Of Green Public Procurement In Western Balkan Countries, Ditjona Kule, Irisi Beleraj Oct 2023

The Impact Of Green Public Procurement In Western Balkan Countries, Ditjona Kule, Irisi Beleraj

UBT International Conference

The sensitivity to environmental preservation toward ethical and sustainable economic growth has been at an all-time high in recent decades. Green public procurement (GPP) is a procedure in which public entities, such as governments or municipalities, purchase goods and services that have a lower environmental effect than conventional alternatives. GPP is gaining popularity in the Western Balkans as a strategy for promoting sustainable development and addressing environmental issues.

The demand for recyclable products, energy-efficient systems, clean technology and fuels, is driving the adoption of ecologically responsible business practices. Private consumers are also encouraged to focus on green purchases. Considering that …


International Conference On Dental Science, University For Business And Technology - Ubt Oct 2023

International Conference On Dental Science, University For Business And Technology - Ubt

UBT International Conference

UBT Annual International Conference is the 11th international interdisciplinary peer reviewed conference which publishes works of the scientists as well as practitioners in the area where UBT is active in Education, Research and Development. The UBT aims to implement an integrated strategy to establish itself as an internationally competitive, research-intensive university, committed to the transfer of knowledge and the provision of a world-class education to the most talented students from all background. The main perspective of the conference is to connect the scientists and practitioners from different disciplines in the same place and make them be aware of the recent …


International Conference On Food Science, University For Business And Technology - Ubt Oct 2023

International Conference On Food Science, University For Business And Technology - Ubt

UBT International Conference

UBT Annual International Conference is the 12th international interdisciplinary peer reviewed conference which publishes works of the scientists as well as practitioners in the area where UBT is active in Education, Research and Development. The UBT aims to implement an integrated strategy to establish itself as an internationally competitive, research-intensive university, committed to the transfer of knowledge and the provision of a world-class education to the most talented students from all background. The main perspective of the conference is to connect the scientists and practitioners from different disciplines in the same place and make them be aware of the recent …


Maple Syrup Urine Disease, Mackenzie Lesczcynski Oct 2023

Maple Syrup Urine Disease, Mackenzie Lesczcynski

D.U.Quark

No abstract provided.


Diversity Operators-Based Artificial Fish Swarm Algorithm To Solve Flexible Job Shop Scheduling Problem, Alaa Wagih Abdulqader, Sura Mazin Ali Oct 2023

Diversity Operators-Based Artificial Fish Swarm Algorithm To Solve Flexible Job Shop Scheduling Problem, Alaa Wagih Abdulqader, Sura Mazin Ali

Baghdad Science Journal

Artificial fish swarm algorithm (AFSA) is one of the critical swarm intelligent algorithms. In this paper, the authors decide to enhance AFSA via diversity operators (AFSA-DO). The diversity operators will be producing more diverse solutions for AFSA to obtain reasonable resolutions. AFSA-DO has been used to solve flexible job shop scheduling problems (FJSSP). However, the FJSSP is a significant problem in the domain of optimization and operation research. Several research papers dealt with methods of solving this issue, including forms of intelligence of the swarms. In this paper, a set of FJSSP target samples are tested employing the improved algorithm …


Impact Of Some Environmental Parameters On Phytoplankton Diversity In The Eastern Al-Hammer Marsh / Southern Iraq, Ebtehal M. Jaffer, Nida J. Al-Mousawi, Imad J. M Al-Shawi Oct 2023

Impact Of Some Environmental Parameters On Phytoplankton Diversity In The Eastern Al-Hammer Marsh / Southern Iraq, Ebtehal M. Jaffer, Nida J. Al-Mousawi, Imad J. M Al-Shawi

Baghdad Science Journal

Biodiversity is one of the important biological factors in determining water quality and maintaining the ecological balance. In this study, there are 223 species of phytoplankton were identified, and they are as follows: 88 species of Bacillariophyta and were at 44%,70 species of Chlorophyta and they were at 29 %, 39 species of Cyanophyta and they were at 16 %, 12 species of Euglenozoa and they were at 4 %, four species of Miozoa and they were at 3 %, and, Phylum Charophyta and Ochrophyta were only eight and two species, respectively and both of them were at 2%. The …


Enolase Inhibitors As Early Lead Therapeutics Against Trypanosoma Brucei, Colm P Roster, Danielle Lavigne, Jillian E Milanes, Emily Knight, Heidi D Anderson, Sabrina Pizarro, Elijah M Harding, Meredith T Morris, Victoria C Yan, Cong-Dat Pham, Florian Muller, Samuel Kwain, Kerrick C Rees, Brian Dominy, Daniel C Whitehead, Md Nasir Uddin, Steven W Millward, James C Morris Oct 2023

Enolase Inhibitors As Early Lead Therapeutics Against Trypanosoma Brucei, Colm P Roster, Danielle Lavigne, Jillian E Milanes, Emily Knight, Heidi D Anderson, Sabrina Pizarro, Elijah M Harding, Meredith T Morris, Victoria C Yan, Cong-Dat Pham, Florian Muller, Samuel Kwain, Kerrick C Rees, Brian Dominy, Daniel C Whitehead, Md Nasir Uddin, Steven W Millward, James C Morris

Faculty, Staff and Student Publications

Glucose metabolism is critical for the African trypanosome, Trypanosoma brucei, serving as the lone source of ATP production for the bloodstream form (BSF) parasite in the glucose-rich environment of the host blood. Recently, phosphonate inhibitors of human enolase (ENO), the enzyme responsible for the interconversion of 2-phosphoglycerate (2-PG) to phosphoenolpyruvate (PEP) in glycolysis or PEP to 2-PG in gluconeogenesis, have been developed for the treatment of glioblastoma multiforme (GBM). Here, we have tested these agents against T. brucei ENO (TbENO) and found the compounds to be potent enzyme inhibitors and trypanocides. For example, (1-hydroxy-2-oxopyrrolidin-3-yl) phosphonic acid (deoxy-SF2312) …


Synergistic Effects Of Applying Potassium Nitrate Spray With Putrescine On Productivity And Fruit Quality Of Mango Trees Cv. Ewais, Abdullah Alebidi, Mahmoud Abdel-Sattar, Laila Y. Mostafa, Alhussein S.A. Hamad, Hail Z. Rihan Oct 2023

Synergistic Effects Of Applying Potassium Nitrate Spray With Putrescine On Productivity And Fruit Quality Of Mango Trees Cv. Ewais, Abdullah Alebidi, Mahmoud Abdel-Sattar, Laila Y. Mostafa, Alhussein S.A. Hamad, Hail Z. Rihan

School of Biological and Marine Sciences

The current investigation represents of the synergistic effects of application of potassium nitrate (KNO3) in combination with putrescine (Put) on flowering, productivity, and fruit quality on Ewais mango (Mangifera indica L.) trees during the seasons 2021/2022 and 2022/2023. The selected trees were sprayed at three different stages, including flower bud differentiation, full bloom, and beginning of the fruit set, with one of the following treatments: control, 2% KNO3, 4% KNO3, 50 ppm Put, 75 ppm Put, 2% KNO3 + 50 ppm Put, 2% KNO3 + 75 ppm Put, 4% KNO3 + 50 ppm Put, 4% KNO3 + 75 ppm Put. …


The Lin28b/Wnt5a Axis Drives Pancreas Cancer Through Crosstalk Between Cancer Associated Fibroblasts And Tumor Epithelium, Zhaoqi Shu, Minghe Fan, Bo Tu, Zhiheng Tang, Haojie Wang, Haimeng Li, Hengchao Li, Meng Yuan, Jingru Bai, Sihan Huo, Lina Wang, Wei-Guo Zhu, Wei Wang, Xiaoyun Liu, Shaokun Shu, Ying Zhao Oct 2023

The Lin28b/Wnt5a Axis Drives Pancreas Cancer Through Crosstalk Between Cancer Associated Fibroblasts And Tumor Epithelium, Zhaoqi Shu, Minghe Fan, Bo Tu, Zhiheng Tang, Haojie Wang, Haimeng Li, Hengchao Li, Meng Yuan, Jingru Bai, Sihan Huo, Lina Wang, Wei-Guo Zhu, Wei Wang, Xiaoyun Liu, Shaokun Shu, Ying Zhao

Faculty, Staff and Student Publications

Bidirectional signal transduction between tumor epithelial cells and tumor microenvironment (TME) is important for tumor development. Here we show that Lin28b/let-7 pathway is indispensable for modulating the expression of Wnt5a in tumor epithelium, which could be secreted and then up-regulates Lin28b in cancer-associated fibroblasts (CAFs). Moreover, we demonstrate that Lin28b in CAFs promoted growth of PDAC by inducing cytokine PCSK9's production. Using an orthotopic mouse model of PDAC, we find that depletion of Lin28b in CAFs reduced tumor weight, highlighting the importance of Lin28b in PDAC stroma. Thus, our study shows that the Lin28b-Wnt5a axis plays a critical role in …