Digital Commons Network^™

Combination Of Thymoquinone And Intermittent Fasting As A Treatment For Breast Cancer Implanted In Mice, Shatha Khaled Haif, Lina T. Al Kury, Wamidh H. Talib

All Works

Breast cancer stands out as a particularly challenging form of cancer to treat among various types. Traditional treatment methods have been longstanding approaches, yet their efficacy has diminished over time owing to heightened toxicity, adverse effects, and the emergence of multi-drug resistance. Nevertheless, a viable solution has emerged through the adoption of a complementary treatment strategy utilizing natural substances and the incorporation of intermittent fasting to enhance therapeutic outcomes. This study aimed to assess the anticancer activity of thymoquinone (TQ), intermittent fasting, and their combination using in vivo and in vitro methods. The anti-proliferative activity of TQ and fasting (glucose/serum …

Dwelling Quality Assessment During Covid-19 Pandemic Self Isolation In East Jakarta, Aisyah Arimurti Afandi

Cities and Urban Development Journal

Background: The government encouraged public health protection with self isolation policy as an effort to control Covid-19 on a wide scale and prevent an increase in occupation rate on health service facilities in order to quickly and effectively handling confirmed cases of Covid-19. Dwelling quality is a significant factor to ensure that self isolation can be carried out effectively since it is stated in public health theory that one of the factors that influences

a person's health status is dwelling quality.

Aims: This research aims to assess dwelling quality where self-isolation being carried out during Covid-19 in East Jakarta. …

Analysis Of Online Zumba Post Covid-19 Pandemic: Case Study Of A Fitness Center In Kemang, South Jakarta, Redidzia Hernandi, Aisyah Arimurti Afandi, Asfarinal ., Garrin Alif Nandhito

Cities and Urban Development Journal

Background: This research discusses the analysis of zumba in the network (online or online) during the Covid-19 pandemic and after the Covid-19 pandemic with the perspective of socio-cultural change.

Aims: The aim of this research is to analyze the implementation of online Zumba and its sustainability after the pandemic.

Methods: The research method used in this research is literature study and interviews which are then analyzed within the framework of the interactional dimension of socio-cultural change theory. The interactional dimension of socio-cultural change theory is defined as a symptom of changing social structures and cultural patterns in a society. The …

Collaborative Strategy In Utilizing Restaurant Leftover Food For Vulnerable Communities In Depok City, Idris Hadi Sikumbang

Cities and Urban Development Journal

Background: The largest waste component every year is waste originating from the wasteful culture and lifestyle of some city residents which has an impact on the generation of waste originating from waste/leftover food.

Aims: This research aims to determine the city community's strategy for utilizing leftover food suitable for consumption produced by restaurants to be used to fulfill food needs for vulnerable communities in Depok City.

Methods: This research was conducted using a mixed research method, explanation design method. The quantitative method consists of distributing questionnaires and observing secondary data, while the qualitative method consists of field observations …

27-Hydroxycholesterol And Dna Damage Repair: Implication In Prostate Cancer, Gloria Cecilia Galvan, Nadine Friedrich, Sanjay Das, James Daniels, Sara Pollan, Shweta Dambal, Ryusuke Suzuki, Sergio Sanders, Sungyong You, Hisashi Tanaka, Yeon-Joo Lee, Wei Yuan, Johann De Bono, Irina Vasilevskaya, Karen Knudsen, Michael Freeman, Stephen Freedland

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

INTRODUCTION: We previously reported that cholesterol homeostasis in prostate cancer (PC) is regulated by 27-hydroxycholesterol (27HC) and that CYP27A1, the enzyme that converts cholesterol to 27HC, is frequently lost in PCs. We observed that restoring the CYP27A1/27HC axis inhibited PC growth. In this study, we investigated the mechanism of 27HC-mediated anti-PC effects.

METHODS: We employed in vitro models and human transcriptomics data to investigate 27HC mechanism of action in PC. LNCaP (AR+) and DU145 (AR-) cells were treated with 27HC or vehicle. Transcriptome profiling was performed using the Affymetrix GeneChip™ microarray system. Differential expression was determined, and gene set enrichment …

Nonprofits, Taxes, And Speech, Lloyd Hitoshi Mayer

Loyola of Los Angeles Law Review

Federal tax law is of two minds when it comes to speech by nonprofits. The tax benefits provided to nonprofits are justified in significant part because they provide nonprofits great discretion in choosing the specific ends and means to pursue, thereby promoting diversity and pluralism. But current law withholds some of these tax benefits if a nonprofit engages in certain types of political speech. Legislators have also repeatedly, if unsuccessfully, sought to expand these political speech restrictions in various ways. And some commentators have proposed denying tax benefits to groups engaged in other types of disfavored speech, including hate speech …

Moving Toward Police Accountability: Beyond Senate Bill 2, Ani Boyadjian

Loyola of Los Angeles Law Review

On September 30, 2021, California Governor Gavin Newsom signed into law Senate Bill 2 (SB 2), “creat[ing] a system to investigate and revoke or suspend peace officer certification for serious misconduct,” as well as establishing the Peace Officer Standards Accountability Division and the Peace Standards Accountability Advisory Board, which will be responsible for investigations into police misconduct. This Note will describe the new features of SB 2’s decertification provisions in contrast to traditional methods of addressing police misconduct. Additionally, this Note will examine where the bill fell short, and how to overcome its shortcomings.

Every Story Has A Beginning, But What About An End?: Disney’S Expiring Copyrights, Marisol Jimenez Gastelum

Loyola of Los Angeles Law Review

The Walt Disney Company is one of the most powerful and influential media companies in the world that has revolutionized animated films. Steamboat Willie, the cartoon featuring the first version of Mickey Mouse, was released in 1928 and is set to enter the public domain on January 1, 2024. This iconic character has stayed out of the public domain for nearly a century because of Congress’s extension of copyright duration in response to lobbying efforts by Disney and other copyright holders. Although Disney has not made another effort to lobby Congress for an extension to its copyrights, Disney’s development of …

Harnessing The Power Of Student Voice: A Case Study Of Hybrid Proficiency-Based And Co-Created Curriculum And Assessment, Kaitlyn A. Seamons

Theses and Dissertations

Assessment has become a dirty word in arts education, because art is notoriously difficult to assess. Assessment, which is often disliked or even disavowed by arts educators, due to its history of incompatibility with the idiosyncratic nature of arts learning, should ideally be utilized as a means of measuring student progress and help teachers understand how to help students succeed. While assessment can also be used to evaluate programs and teachers and to compare student successes relative to those of other students, I will be focusing on measuring individual student progress for my thesis and building a curriculum to support …

Playing To Grow. Roundtable Interview On Games, Education, And Character, Owen Gottlieb, Matthew Farber, Paul Darvasi

Articles

In this roundtable interview moderated by Paul Darvasi, lecturer at the University of Toronto and co-founder of Gold Bug Interactive, Owen Gottlieb and Matthew Farber discuss research and practice at the intersection of religion, character education, and games in schools. Gottlieb is an associate professor at the Rochester Institute of Technology, founder and lead faculty at the Initiative in Religion, Culture, and Policy at the MAGIC center, and founder and director of the Interaction, Media, and Learning Lab at RIT, where he specializes in interactive media, learning, religion, and culture. Farber is an associate professor of educational technology and coordinator …

Technology Justice: Taxation Of Our Collective And Cumulative Cognitive Inheritance, Hilary G. Escajeda

Loyola of Los Angeles Law Review

As artificial intelligence and robotic technologies accelerate economic transformation, outdated property and tax laws will increasingly fail American workers with ordinary skills that perform routine job functions. Because technology may render millions of workers redundant, U.S. policymakers must make significant social, economic, and legal structural changes to (1) improve the lives of average workers, (2) support the economy, and (3) maintain political stability.

Inspired by Thomas Paine’s Agrarian Justice, this twenty-first century Article argues that “Technology Justice” requires that humans benefit from the cognitive endowment created by our ancestors’ minds. Specifically, it asserts that our collective and cumulative cognitive …

Exploring Attitudes Toward “Sugar Relationships” Across 87 Countries: A Global Perspective On Exchanges Of Resources For Sex And Companionship, Norbert Meskó, Marta Kowal, András Láng, Ferenc Kocsor, Szabolcs A. Bandi, Adam Putz, Piotr Sorokowski, David A. Frederick, Felipe E. García, Leonardo A. Aguilar, Anna Studzinska, Chee Seng Tan, Biljana Gjoneska, Taciano L. Milfont, Bulut M Topcu, Dmitry Grigoryev, Toivo Aavik, Mahmoud Boussena, Alan D.A. Mattiassi, Reza Afhami, Rizwana Amin, Roberto Baiocco, Hamdaoui Brahim, Ali R. Can, Joao Carneiro, Hakan Çetinkaya, Dimitri Chubinidze, Eliane Deschrijver, Yahya Don, Dmitrii Dubrov, Izzet Duyar, Marija Jovic, Julia A. Kamburidis, Farah Khan, Hareesol Khun-Inkeeree, Maida Koso-Drljevic, David Lacko, Karlijn Massar, Mara Morelli, Jean C. Natividade, Ellen K. Nyhus, Ju Hee Park, Farid Pazhoohi, Ekaterine Pirtskhalava, Koen Ponnet, Pavol Prokop, Dušana Šakan, Singha Tulyakul, Austin H. Wang, Sibele D. Aquino, Derya D. Atamtürk, Nana Burduli, Antonio Chirumbolo, Seda Dural, Edgardo Etchezahar, Moharrampour N Ghahraman, Balazs Aczel, Luca Kozma, Samuel Lins, Efisio Manunta, Tiago Marot, Moises Mebarak, Kirill G. Miroshnik, Katarina Misetic, Marietta Papadatou-Pastou, Bence Bakos, Fatima Zahra Sahli, Sangeeta Singh, Çağlar Solak, Tatiana Volkodav, Anna Wlodarczyk, Grace Akello, Marios Argyrides, Ogeday Çoker, Katarzyna Galasinska, Yepes T Gómez, Aleksander Kobylarek, Miguel Landa-Blanco, Marlon Mayorga, Barış Özener, Ma Criselda T. Pacquing, Marc Eric S. Reyes, Ayşegül Şahin, William Tamayo-Agudelo, Gulmira Topanova, N/A Toplu-Demir

School of Psychology

The current study investigates attitudes toward one form of sex for resources: the so-called sugar relationships, which often involve exchanges of resources for sex and/or companionship. The present study examined associations among attitudes toward sugar relationships and relevant variables (e.g., sex, sociosexuality, gender inequality, parasitic exposure) in 69,924 participants across 87 countries. Two self-report measures of Acceptance of Sugar Relationships (ASR) developed for younger companion providers (ASR-YWMS) and older resource providers (ASR-OMWS) were translated into 37 languages. We tested cross-sex and cross-linguistic construct equivalence, cross-cultural invariance in sex differences, and the importance of the hypothetical predictors of ASR. Both measures …

Current Biomedical Applications Of 3d-Printed Hydrogels, Allan John R Barcena, Kashish Dhal, Parimal Patel, Prashanth Ravi, Suprateek Kundu, Karthik Tappa

Faculty, Staff and Student Publications

Three-dimensional (3D) printing, also known as additive manufacturing, has revolutionized the production of physical 3D objects by transforming computer-aided design models into layered structures, eliminating the need for traditional molding or machining techniques. In recent years, hydrogels have emerged as an ideal 3D printing feedstock material for the fabrication of hydrated constructs that replicate the extracellular matrix found in endogenous tissues. Hydrogels have seen significant advancements since their first use as contact lenses in the biomedical field. These advancements have led to the development of complex 3D-printed structures that include a wide variety of organic and inorganic materials, cells, and …

Mir-410 Is A Key Regulator Of Epithelial-To-Mesenchymal Transition With Biphasic Role In Prostate Cancer, Diana M Asante, Amritha Sreekumar, Sandip Nathani, Tae Jin Lee, Ashok Sharma, Nikhil Patel, Matthew N Simmons, Sharanjot Saini

Faculty, Staff and Student Publications

The molecular basis of prostate cancer (PCa) progression from the primary disease to metastatic castration-resistant prostate cancer (CRPC) followed by therapy-induced neuroendocrine prostate cancer is not fully understood. In this study, we elucidate the role of miR-410, a little-studied microRNA located on chromosome 14q32.31 within the DLK1-DIO3 cluster, in PCa. miR-410 expression analyses in primary and metastatic PCa tissues and cell lines show that its levels are decreased in initial stages and increased in advanced PCa. Functional studies were performed in a series of PCa cell lines. In LNCaP cells, miR-410 overexpression led to decreases in cellular viability, proliferation, invasiveness, …

Intergenerational Co-Production In Digital Design For Health, Well-Being, And Social Connection, Catherine Hennessy, Greg Mannion, Richard Haynes, Anna Whittaker, Hannah Bradwell, Simone Tomaz, John Ritchie, Leonie Cooper

School of Nursing and Midwifery

No abstract provided.

Immunosequencing Applications In Cutaneous T-Cell Lymphoma, Jenna Mandel, Laura Gleason, Daniel Joffe, Safiyyah Bhatti, Neda Nikbakht

Department of Dermatology and Cutaneous Biology Faculty Papers

Immunosequencing has emerged as a newer clinical test for assessment of T-cell clonality in the blood and skin of cutaneous T-cell lymphoma (CTCL) patients. Utilization of immunosequencing, also known as high-throughput sequencing of the T-cell receptor (HTS-TCR), enables identification and quantification of the precise genetic signature of dominant T-cell clones. Although immunosequencing is more sensitive than commonly used methods such as polymerase chain reaction (PCR) paired with capillary electrophoresis or flow cytometry, it remains underutilized for CTCL management. Nonetheless, incorporation of HTS-TCR in clinical practice offers distinct advantages compared to other molecular analyses that may improve diagnostic evaluation, prognostication, and …

Using Ai-Supported Supervision In A University Telemental Health Training Clinic, Donna Sheperis, Shiri Sadeh-Sharvit

Journal of Technology in Counselor Education and Supervision

Artificial Intelligence (AI) technologies have the potential of transforming clinical education and supervision in university-based telemental health training clinics. AI can improve the accuracy of diagnoses, automate routine tasks, and personalize treatment plans, potentially enhancing the accessibility and quality of mental health care. In this paper, we describe why training clinics serve as an optimal setting to adopt innovation and share lessons from the field to inform future integrations of AI in clinical supervision. The lessons include support for case conceptualization, feedback on session quality, and automation of routine tasks such as sending standardized assessments and writing progress notes. However, …

Artificial Intelligence, Virtual Reality, And Augmented Reality In Counseling: Distinctions, Evidence, And Research Considerations, Sidney Shaw, Sophie Oswin, Yue Xi, Fallon Calandriello, Russell Fulmer

Journal of Technology in Counselor Education and Supervision

Technology is experiencing a growing presence in counseling and mental health, attracting attention from counselors, researchers, and the general public. This growth has the potential to change counseling practice, counselor education, and how users access mental health services. In this article we provide definitions of and distinctions between three common technologies that are used in the counseling field—Artificial Intelligence, Virtual Reality, and Augmented Reality. We also provide examples of the use of each technology, ethical implications, research support, and recommendations for future research.

Artificial Intelligence For Mental Health Support During Covid-19: Experiences Of Graduate Counseling Students, Russell Fulmer, Eric T. Beeson, Carl Sheperis, Daniel Rosello, Rebecca Edelman

Journal of Technology in Counselor Education and Supervision

The purpose of this study was to examine how an AI chatbot could provide mental health support to counselors-in-training during the COVID-19 pandemic. The chatbot “Tess” was available to participants for two weeks. Participants responded to questions about their experience and the content of this qualitative data was analyzed. Themes emerged that focused on mental health during the pandemic, utility of the AI chatbot during the pandemic, and potential therapeutic use in general. Findings were mixed and suggest some skepticism among counseling students towards the use of an AI chatbot.

Towards Ethical Artificial Intelligence In Universities: Chatgpt, Culture, And Mental Health Stigmas In Asian Higher Education Post Covid-19, Michael James Day

Journal of Technology in Counselor Education and Supervision

Mental health can be interpreted as a social taboo in Asia, ensuring that students with mental health stigmas (SWMHS) face complex educational journeys that impact their wellbeing. This article provides a conceptual interdisciplinary commentary that illustrates how in Asian higher education (HE) settings, the psychosocial phenomena of face culture, a sociolinguistic blend of high-context power relations, sense-making, and cultural capital, defines human-to-human (HTH) dialogue. It suggests that human-to-computer-interaction (HCI) through artificial intelligence (AI) technologies, such as ChatGPT, could improve university wellbeing strategies in Asia. The article situates AI discussion into the sociolinguistic features of face culture in Thailand and China …

Missing The Point- The Disappointed Hope Of Self- Publishing Authors, Simone Schroff

School of Law, Humanities and Social Sciences

Trade book publishing is characterised by authors with weaker bargaining power than the commercial intermediaries, including publishers and distributors. One key solution representing the empowerment of authors is self-publishing works, thereby cutting out the gatekeeper. However, self-publication has failed to improve the position of authors: their incomes continue to fall across the sector. Using social network analysis as well as industry practices, this article examines UK trade book publishing dynamics. It argues that the reason for the self-publication route’s ‘underperformance’ is structural, explained by a realistic view of the publishing sector and the relationships it entails. The self- publishing author …

Introduction: Market Dynamics And Worship Technology, Nicholas Zork

Faculty Publications

No abstract provided.

Ints6 And The Integrator Phosphatase Module Tune The Efficiency Of Select Premature Transcription Termination Events, Rina Fujiwara, Si-Nan Zhai, Dongming Liang, Aayushi P Shah, Matthew Tracey, Xu-Kai Ma, Christopher J Fields, María Saraí Mendoza-Figueroa, Michele C Meline, Deirdre C Tatomer, Li Yang, Jeremy E Wilusz

Children’s Nutrition Research Center Staff Publications

The metazoan-specific Integrator complex catalyzes 3' end processing of small nuclear RNAs (snRNAs) and premature termination that attenuates the transcription of many protein-coding genes. Integrator has RNA endonuclease and protein phosphatase activities, but it remains unclear if both are required for complex function. Here, we show IntS6 (Integrator subunit 6) over-expression blocks Integrator function at a subset of Drosophila protein-coding genes, although having no effect on snRNAs or attenuation of other loci. Over-expressed IntS6 titrates protein phosphatase 2A (PP2A) subunits, thereby only affecting gene loci where phosphatase activity is necessary for Integrator function. IntS6 functions analogous to a PP2A regulatory …

The Involvement Of Hepatic Cytochrome P450s In The Cytotoxicity Of Lapatinib, Si Chen, Xilin Li, Yuxi Li, Xiaobo He, Matthew Bryant, Xuan Qin, Feng Li, Ji-Eun Seo, Xiaoqing Guo, Nan Mei, Lei Guo

Faculty, Staff and Students Publications

Lapatinib, an oral tyrosine kinase inhibitor used as a first-line treatment for HER2-positive breast cancer, has been reported to be associated with hepatotoxicity; however, the underlying mechanisms remain unclear. In this study, we report that lapatinib causes cytotoxicity in multiple types of hepatic cells, including primary human hepatocytes, HepaRG cells, and HepG2 cells. A 24-h treatment with lapatinib induced cell cycle disturbances, apoptosis, and DNA damage, and decreased the protein levels of topoisomerase in HepG2 cells. We investigated the role of cytochrome P450 (CYP)-mediated metabolism in lapatinib-induced cytotoxicity using our previously established HepG2 cell lines, which express each of 14 …

Releasing The Captives: How The National Labor Relations Board Can Correct The Anomalous Captive Audience Meeting Doctrine, Adam J. Drapcho

University of Cincinnati Law Review

No abstract provided.

A Right Without A Remedy: How One Cincinnatian's Story Illustrates Terrorism Victims' Inability To Obtain Compensation Under The Foreign Sovereign Immunities Act, Christopher T. Colloton

University of Cincinnati Law Review

No abstract provided.

Vega V. Tekoh And The Erosion Of Miranda: A Reframing Of Miranda As A Procedural Due Process Requirement, Tess A. Chaffee

University of Cincinnati Law Review

No abstract provided.

Must Courts Recalibrate Tort Law Governing Firearms In Light Of The Second Amendment?, Lars Noah

University of Cincinnati Law Review

The rules governing the scope of liability in cases where firearms cause injuries—some well-established, others fairly novel—help to define the responsibilities of users, owners, and sellers of these popular but dangerous products. As the U.S. Supreme Court has recently expanded an individual’s right to keep and bear arms, some have wondered whether the Second Amendment might operate to limit the reach of these various tort doctrines. Sixty years ago, the Court started to constitutionalize various aspects of state common law, most famously using the First Amendment to limit defamation claims but in other respects as well. A comparable approach to …

Pooling And Exchanging Competitively Sensitive Information Among Rivals: Absolutely Illegal Not Just Unreasonable, Peter C. Carstensen, Annkathrin Marschall

University of Cincinnati Law Review

An agreement to exchange competitive sensitive information among rivalrous competitors usually results from an intent to inhibit or restrict the discretion of those firms to engage in competition. Basic economic logic about competition leads to that conclusion. Hence, such an exchange is in itself a naked agreement in restraint of trade without legal justification. Currently, case law requires a more convoluted and irrelevant inquiry into market definition and market power before a court can condemn such agreements. This is the result of ambiguous Supreme Court decisions as well as the recognition that in a few instances there are plausible arguments …

Section 230 As Civil Rights Statute, Enrique Armijo

University of Cincinnati Law Review

Many of our most pressing discussions about justice, progress, and civil rights have moved online. Activists advocating for social change no longer need to be in the same physical space to connect with others who share their challenges and aspirations. But the convergence of mobility, connectivity, and technology is not the only reason why. Thanks to Section 230 of the Communications Decency Act’s (“Section 230”) immunity for online platforms, websites, and their hosts, speakers can engage in speech about protest, equality, and dissent without fear of collateral censorship from governments, authorities, and others in power who hope to silence them. …