Digital Commons Network^™

Phenotyping Emt And Met Cellular States In Lung Cancer Patient Liquid Biopsies At A Personalized Level Using Mass Cytometry, Loukia G Karacosta, Danny Pancirer, Jordan S Preiss, Jalen A Benson, Winston Trope, Joseph B Shrager, Arthur Wai Sung, Joel W Neal, Sean C Bendall, Heather Wakelee, Sylvia K Plevritis

Faculty, Staff and Student Publications

Malignant pleural effusions (MPEs) can be utilized as liquid biopsy for phenotyping malignant cells and for precision immunotherapy, yet MPEs are inadequately studied at the single-cell proteomic level. Here we leverage mass cytometry to interrogate immune and epithelial cellular profiles of primary tumors and pleural effusions (PEs) from early and late-stage non-small cell lung cancer (NSCLC) patients, with the goal of assessing epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) states in patient specimens. By using the EMT-MET reference map PHENOSTAMP, we observe a variety of EMT states in cytokeratin positive (CK+) cells, and report for the first time MET-enriched CK+ …

The Defined Tlr3 Agonist, Nexavant, Exhibits Anti-Cancer Efficacy And Potentiates Anti-Pd-1 Antibody Therapy By Enhancing Immune Cell Infiltration, Seung-Hwan Lee, Young-Ho Choi, Soon Myung Kang, Min-Gyu Lee, Arnaud Debin, Eric Perouzel, Seung-Beom Hong, Dong-Ho Kim

Faculty, Staff and Student Publications

Nexavant was reported as an alternative to the TLR3 agonist of Poly(I:C) and its derivatives. The physicochemical properties, signaling pathways, anti-cancer effects, and mechanisms of Nexavant were investigated. The distinctive characteristics of Nexavant compared to that of Poly(I:C) were demonstrated by precise quantification, enhanced thermostability, and increased resistance to RNase A. Unlike Poly(I:C), which activates TLR3, RIG-I, and MDA5, Nexavant stimulates signaling through TLR3 and RIG-I but not through MDA5. Compared to Poly(I:C), an intratumoral Nexavant treatment led to a unique immune response, immune cell infiltration, and suppression of tumor growth in various animal cancer models. Nexavant therapy outperformed anti-PD-1 …

Addressing Water Hyacinth (Pontederia Crassipes) Impacts On Aquatic Biota In Lake Okeechobee, Joseph Salerno

All HCAS Student Capstones, Theses, and Dissertations

The incursion of water hyacinth, Pontederia crassipes in Lake Okeechobee has resulted in management systems to be implemented to reduce the coverage of the invasive macrophyte. Its residence in the Lake Okeechobee ecosystem and the effects it has on organisms in the lake, whether it be positive or harmful is unknown. This study attempted to assess the potential effects that water hyacinth has on aquatic biota in Lake Okeechobee. Biotic data were collected on open water, water hyacinth covered, and native vegetation covered habitats via hook-and-line fishing, electrofishing, baited minnow traps, and the sampling of plant roots over a thirteen-month …

2023-12-08, Board Of Regents, Murray State University

Board of Regents Meeting Minutes

No abstract provided.

The Development Of A Young Adults Cancer Patient Peer Match Application, Mojde Kalantari

Theses and Dissertations

This thesis explores the challenges and needs of young adult cancer patients, along with potential online resources to aid them, that includes social media, public and private organizations, and mobile applications. The focus of this research narrows down to communication and social networking mobile applications, particularly those with peer matching features. Although there are only three social apps in this category, a comprehensive analysis was undertaken. The research aims to underscore the need for a dedicated mobile application that connects young adult cancer patients with the same diagnosis. In response to this need, a mobile app named "YA Peer Match" …

A View Of Black Speculative Past And Future: An Interview With Tim Fielder, Julian Chambliss

Third Stone

No abstract provided.

Afrofantastic Presents: The Many Deaths Of Oscar Mack, Julian Chambliss

Third Stone

Oscar Mack's story deserves the dedication that has culminated in the creation of this defining documentary. Mack's struggle to survive is ripe for the Afrofuturist re‐telling, not because it is fantastic but because the comic story has the potential to capture the transformative thinking black people must employ to survive.

Tolkien's Faith: A Spiritual Biography (2023) By Holly Ordway, Tom Emanuel

Journal of Tolkien Research

Book review, by Tom Emanuel, of Tolkien's Faith (2023) by Holly Ordway

Full Issue

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

No abstract provided.

Special Thanks To Kirk Magleby And Ken Porter

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

Two hard-working FARMS officers have stepped down this month. Ken Porter, our Vice President in charge of Development, has recently accepted a mission call to serve with his wife, Ann, in England. Ann has also been working for FARMS as a secretary. We wish them great success!

Creating A Safer Lgbtqi+ Refugee Experience In Kakuma Camp, Wren King

Mountaineer Undergraduate Research Review

In December of 2013, Uganda passed the controversial Anti-Homosexuality Bill, which broadly criminalized same-sex relationships and supported the livelihoods of individuals in same-sex relationships, permitting sentences of life in prison for some sex acts. Ugandans fled the country to protect their safety. Many came to Kenya, a large majority coming to Kakuma Camp in the northwestern part of the country. At least 400 LGBTQI+ Ugandans arrived in the country between January 2014 and February 2015. Their resettlement was initially expedited and comparatively generous resources were made available to them. However, by the end of 2014, UNHCR and its partner organizations …

"Salamanders" And "Short-Hand Egyptian"

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

The 1830 letter of Martin Harris to W. W. Phelps, published in the Church News in April, has already attracted national attention. In this letter, Harris describes an early spiritual appearance to Joseph Smith, stating that "the spirit transfigured himself from a white salamander in the bottom of the hole."

Farms Finishes Three Major Projects In June

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

June has been a productive month. Thanks to hundreds of volunteer hours, three significant projects have recently been completed. We think you will be interested in each of them.

Is Early Sport Specialization Harming Our Children?, Kendra Dunsford Dpt, Scs, Stc, Preeti Oza Pt, Phd

Pacific Journal of Health

Sports and physical activity in children are healthy and have numerous positive mental and physical health benefits. Recently, there has been a shift away from deliberate play and focusing on specializing in a single sport from a young age. Participating in rigorous training and competition schedules 8 months out of the year for prepubescent athletes has garnered attention from the medical community. It is assumed that this type of early specialization has the potential to cause negative effects, especially in terms of overuse injuries, nutritional deficiencies, poor sleep hygiene, and mental health concerns. While there appears to be a consensus …

Costs Associated With Voluntary Speed Reduction Requests In Central California Marine Sanctuaries To Protect Endangered Whales, K. Eric Wolfe, Ian A. Mathis

Journal of Ocean and Coastal Economics

International trade is vital to the U.S. economy. As waterborne traffic accounts for about 40 percent of all international cargo value and 70 percent of international tonnage, regulatory changes involving waterborne transportation may significantly impact the United States (US) economy on both local and national levels. A Voluntary Speed Reduction (VSR) program reduces vessel speeds off the central coast of California for vessels 300 gross tons and larger from May 1^st to November 15^th to protect whales and other marine mammals. This study investigates the magnitude of changes in vessel costs associated with VSR requests.

This analysis contributes …

Virginia Refugee’S Access To Covid 19 Health Information, Krunal Patel, Sarah R. Blackstone, Fern R. Hauck

Virginia Journal of Public Health

Background: This study examined how refugees in central Virginia, United States were able to access public health information about COVID-19 and any barriers to following COVID-19 prevention guidelines.

Methods: Individual interviews were conducted with refugees (n = 40) attending a family medicine clinic serving refugees and immigrants. Participants answered questions about their primary methods of obtaining COVID-19 and COVID-19 vaccine information, how they prefer to receive this information, information given by employers, precautions taken at their place of work, and current vaccination status.

Results: We found that television and social media played a large role for refugees in obtaining COVID-19 …

Jesuit Educational Principles And Student Managed Investment Funds, Mehmet F. Dicle

Jesuit Higher Education: A Journal

Financial education is part of Jesuit higher education. One of the important parts of the finance curriculum is the student managed investment fund (SMIF). In this study we provide an example SMIF which is structured around Jesuit ideals. Ethics and social responsibility are at the core of the investment and payout processes. Our students consistently strive to outperform financial markets, pay scholarships from their profits, and address the needs of their community. They show solidarity with the greater student community by offering their knowledge, talents and efforts to earn profits to help those who are in need. They also show …

Restorative Recreation: A Medical Humanities Course Relating Nature Prescription, Avocation, And Creation Care To Human And Ecosystem Health, Patrick C. Swanson, Keirien L. Taylor, Thomas J. Schechter

Jesuit Higher Education: A Journal

Although there is increasing awareness of the relationships between ecosystem health, access to and interaction with nature, and human wellness, examples of instructional activities to convey these issues in medical education are limited. To address this need, P.C.S. developed a five week elective course for up to twelve students within a medical humanities curriculum. Students discuss themes covered in multi-media assignments, hike at a regional nature center, and write a final reflection essay. Discussion topics include nature-deficit disorder, nature immersion, nature prescription, creation care, social determinants of nature access and environmental health, and restorative recreation as an avocation. Follow-up surveys …

Possibility Thinking In The Community-Engaged Classroom: Uniting Hope And Imagination Towards Anti-Racist Action, Betsy Bowen, Lilly Campbell, Jenna Green, Emily A. Phillips

Jesuit Higher Education: A Journal

Drawing on the work of Patrick Saint-Jean, S.J., this article examines the contribution that “possibility thinking” makes to community-engaged learning at three Jesuit universities. The article considers ways in which possibility thinking intersects both Jesuit and secular perspectives on hope and imagination, and their relationship to anti-racist praxis. We then describe three institutional contexts at different stages of enacting community-engaged learning in introductory and upper-level English classes. The article concludes by offering three praxis-oriented directions for community-engaged learning educators to take up in their own institutional contexts: developing faculty capacity and awareness; fostering solidarity not charity; and encouraging reflection not …

Implications Of A Community-Based Learning Faculty Fellows Program To Facilitate Teaching And Learning In The Jesuit Tradition, Debra Fetherman, Julie Schumacher Cohen, Ovidiu Cocieru, Gerard Dumancas, Brian Snee, Patricia Wisniewski

Jesuit Higher Education: A Journal

The University of Scranton is one of the 28 Jesuit institutions of higher education located in the United States. Committed to community engagement and the development of Ignatian educators, a Community-Based Learning (CBL) Faculty Fellows Program was implemented academic year 2022-2023. The Ignatian Pedagogical Paradigm and the Engagement of Hope framework were used as models to develop, implement, and assess a CBL faculty development program. Program activities were designed to build faculty skills, capacities, and their identity as community-engaged practitioners. Lessons learned through program assessment on the impact on faculty’s transformation to Ignatian educators and their ability to imagine new …

Lo Que Realmente Significa Magis Y Por Qué Importa, Fr. Barton T. Geger S.J.

Jesuit Higher Education: A Journal

Muchas definiciones del magis se proponen en los círculos jesuitas, no todas las cuales son claras o útiles. La mejor definición, en términos de practicidad, fidelidad a las fuentes y correspondencia con otros temas ignacianos, es “el bien más universal”. Está estrechamente relacionada con el lema no oficial de la Compañía de Jesús, “Para la mayor gloria de Dios”.

New Approaches For Teaching Advertising: Looking Through The Lens Of Social Justice To Affect Career Behaviors And Choices, Pamela K. Morris, Minjin (Mj) Rheu

Jesuit Higher Education: A Journal

This exploratory study reviewed how a way of teaching advertising and strategic communication through the lens of social justice and as an active agent to impact society influenced student perspectives. Weaving together engaged scholarship and engagement of hope as a framework for investigation, an introductory advertising course was designed to incorporate social justice, diversity, equity, and inclusion (DEI). Students were interviewed about their learnings, feelings, and career hopes and choices. Assignments and year end reflections were also examined for ideas of social justice and pedagogical approaches. Findings indicate students are knowledgeable of the power and influence of advertising and are …

Combining High-Impact Practices To Facilitate Hope For Young Adults Transitioning Into College, Isabelle A. Jenkins, Alison Bryant Ludden, Michelle C. Sterk Barrett

Jesuit Higher Education: A Journal

Today’s societal challenges are causing young people to feel less hopeful about the future, negatively impacting their mental health. Educators are called to address this crisis and provide opportunities for young people to experience hope. Jesuit colleges and universities are uniquely poised to do so given their focus on caring for the whole person and the recent release of the Universal Apostolic Preferences, which prioritize “journeying with youth in the creation of a hope-filled future.” High-impact practices at Jesuit institutions could particularly be effective given the ways in which they intellectually engage students and help students cultivate a sense of …

Imagination Grasping Reality: An Ignatian Foundation For Critical Hope In Jesuit Education, Susan Haarman

Jesuit Higher Education: A Journal

As public faith in higher education faces an all time low, the need for hope to both infuse and be a product of our institutions of higher learning is paramount. Rather than a simple hopeful optimism, Henry Giroux conceptualized critical hope - an educated hope that will form students capable and willing to view themselves and the world through a critical lens and then imagine new ways of proceeding that serve the public good and honor human dignity. Jesuit education, at its best, is rooted in expressions of critical hope with a world-affirming commitment to depth of thought and imagination …

The Circle Of Insight: A Process For Deepening Ignatian Imagination, And Inviting Hope, Anthony Nicotera

Jesuit Higher Education: A Journal

Former Jesuit, educator, scholar, clinical social worker, peace and justice activist and advocate, and co-director of Seton Hall University’s Catholic Social Thought (CST) in Action Academy and NYU’s Post-Master’s Certificate Program in Spirituality and Social Work, Dr. Anthony Nicotera shares his Circle of Insight framework as a tool for deepening Ignatian imagination and inviting hope. The Circle of Insight’s See, Reflect, Act process, inspired by CST, and curated and created by Dr. Nicotera over twenty-five years of spiritual, social justice, and social work advocacy and practice, including teaching social justice courses and engaging in nonviolent civil resistance, builds on Ignatian …

Robust Anti-Deepfake Measures For Audio Using Blockchain And Machine Learning, Stephane Belmon, Roshan Rammohan

Defensive Publications Series

Deepfake audio is fake audio where the content, while sounding like it is in the voice of a particular speaker, is not actually spoken by the person. With the advent of deepfakes, verifying audio as being provided by a particular person, e.g., a public figure or other party of interest, and at a particular time and location is important to promote trust within a society. This disclosure describes techniques that enable the listener of a particular piece of audio to verify that the audio was indeed created by the person associated with the voice. A recorder that is certified as …

Sr 23-24-11 Cc, Marshall University Faculty Senate

Recommendations

No abstract provided.

Cypress Ridgeville Church Council Minutes 2006-2015, Cypress United Methodist Church, Ridgeville

Methodist Local Church Records

No abstract provided.

Victim Blaming And Character Assassination: Media Framing Of Controversial Issues Of Bangladesh, Meherun Nahar, Tasnim Tabassum, Rafikatun Nisa

Informasi

News framing plays a significant role in creating and diverting perceptions on controversial issues in Bangladesh. The study examines three selected occurrences involving renowned personalities to discover the factors that contribute to the sensationalization of news information. The research posits theme-based criteria that influence news framing and investigates how controversy spreads via conventional and internet media. According to the study, online news portals participate in more news framing than conventional media. Victim blaming and character assassination are frequent framing strategies utilized in the online domain. The framing factors include misleading headlines, improper wording, and distortion of context. Thematic analysis of …

Vol.51 N.20 December 7th 2023, Voice Media Ventures

Black Voice News

No abstract provided.