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The Statewide Standard, 2023, College Of Education

The Statewide Standard

No abstract provided.

The Importance Of Winter Dinoflagellate Blooms In Chesapeake Bay— A Missing Link In Bay Productivity, Nicole C. Millette, Sophie Clayton, Margaret R. Mulholland, Leah Gibala-Smith, Michael Lane

OES Faculty Publications

It is widely assumed that phytoplankton abundance and productivity decline during temperate winters because of low irradiance and temperatures. However, winter phytoplankton blooms commonly occur in temperate estuaries, but they are often undocumented because of reduced water quality monitoring in winter. The small body of in situ work that has been done on winter blooms suggests they can be of enormous consequence to ecosystems. However, because monitoring is often reduced or stopped altogether during winter, it is unclear how widespread these blooms are or how long they can last. We analyzed an over 30-year record of monthly phytoplankton monitoring samples …

Racial Pay Equity In “White” Collar Workplaces, Nantiya Ruan

Scholarly Works

Part I outlines the many ways that corporate employers fail in racial equity efforts and the barriers that have been put into place to keep BIPOC workers from succeeding. Drawing from industrial organizational psychology and sociology, I identify six distinct challenges that must be remedied or ameliorated in order for BIPOC to achieve pay equity in the corporate climate. Part II identifies and analyzes the decades of litigation and class action settlements that have tried and failed to address the persistent lack of BIPOC representation in the financial industry. I categorize these cases into three waves of litigation intended to …

Binary Classification Of The Endocrine Disrupting Chemicals By Artificial Neural Networks, Zahir Aghayev, George F Walker, Funda Iseri, Moustafa Ali, Adam T Szafran, Fabio Stossi, Michael A Mancini, Efstratios N Pistikopoulos, Burcu Beykal

Faculty, Staff and Students Publications

We develop a machine learning framework that integrates high content/high throughput image analysis and artificial neural networks (ANNs) to model the separation between chemical compounds based on their estrogenic receptor activity. Natural and man-made chemicals have the potential to disrupt the endocrine system by interfering with hormone actions in people and wildlife. Although numerous studies have revealed new knowledge on the mechanism through which these compounds interfere with various hormone receptors, it is still a very challenging task to comprehensively evaluate the endocrine disrupting potential of all existing chemicals and their mixtures by pure

Rdkg: A Reinforcement Learning Framework For Disease Diagnosis On Knowledge Graph, Shipeng Guo, Kunpeng Liu, Pengfei Wang, Weiwei Dai, Yi Du, Yuanchun Zhou, Wenjuan Cui

Computer Science Faculty Publications and Presentations

Automatic disease diagnosis from symptoms has attracted much attention in medical practices. It can assist doctors and medical practitioners in narrowing down disease candidates, reducing testing costs, improving diagnosis efficiency, and more importantly, saving human lives. Existing research has made significant progress in diagnosing disease but was limited by the gap between interpretability and accuracy. To fill this gap, in this paper, we propose a method called Reinforced Disease Diagnosis on Knowlege Graph (RDKG). Specifically, we first construct a knowledge graph containing all information from electronic medical records. To capture informative embeddings, we propose an enhanced knowledge graph embedding method …

A Rapid, Low-Cost, And Highly Sensitive Sars-Cov-2 Diagnostic Based On Whole-Genome Sequencing, Per A Adastra, Neva C Durand, Namita Mitra, Saul Godinez Pulido, Ragini Mahajan, Alyssa Blackburn, Zane L Colaric, Joshua W M Theisen, David Weisz, Olga Dudchenko, Andreas Gnirke, Suhas S P Rao, Parwinder Kaur, Erez Lieberman Aiden, Aviva Presser Aiden

Faculty, Staff and Students Publications

Early detection of SARS-CoV-2 infection is key to managing the current global pandemic, as evidence shows the virus is most contagious on or before symptom onset. Here, we introduce a low-cost, high-throughput method for diagnosing and studying SARS-CoV-2 infection. Dubbed Pathogen-Oriented Low-Cost Assembly & Re-Sequencing (POLAR), this method amplifies the entirety of the SARS-CoV-2 genome. This contrasts with typical RT-PCR-based diagnostic tests, which amplify only a few loci. To achieve this goal, we combine a SARS-CoV-2 enrichment method developed by the ARTIC Network (https://artic.network/) with short-read DNA sequencing and de novo genome assembly. Using this method, we can reliably ( …

Semi-Automated Construction Of Patient-Specific Aortic Valves From Computed Tomography Images, Dan Lior, Charles Puelz, Colin Edwards, Silvana Molossi, Boyce E Griffith, Ravi K Birla, Craig G Rusin

Faculty, Staff and Students Publications

This paper presents a semi-automatic method for the construction of volumetric models of the aortic valve using computed tomography angiography images. Although the aortic valve typically cannot be segmented directly from a computed tomography angiography image, the method described herein uses manually selected samples of an aortic segmentation derived from this image to inform the construction. These samples capture certain physiologic landmarks and are used to construct a volumetric valve model. As a demonstration of the capabilities of this method, valve models for 25 pediatric patients are created. A selected valve anatomy is used to perform fluid-structure interaction simulations using …

Prefrontal Network Engagement By Deep Brain Stimulation In Limbic Hubs, Anusha Allawala, Kelly R Bijanki, Denise Oswalt, Raissa K Mathura, Joshua Adkinson, Victoria Pirtle, Ben Shofty, Meghan Robinson, Matthew T Harrison, Sanjay J Mathew, Wayne K Goodman, Nader Pouratian, Sameer A Sheth, David A Borton

Faculty, Staff and Students Publications

Prefrontal circuits in the human brain play an important role in cognitive and affective processing. Neuromodulation therapies delivered to certain key hubs within these circuits are being used with increasing frequency to treat a host of neuropsychiatric disorders. However, the detailed neurophysiological effects of stimulation to these hubs are largely unknown. Here, we performed intracranial recordings across prefrontal networks while delivering electrical stimulation to two well-established white matter hubs involved in cognitive regulation and depression: the subcallosal cingulate (SCC) and ventral capsule/ventral striatum (VC/VS). We demonstrate a shared frontotemporal circuit consisting of the ventromedial prefrontal cortex, amygdala, and lateral orbitofrontal …

Datasets From: Application Of Aerial Insar To Measure Glacier Elevations, Bryce Glenn, Andrew G. Fountain, Delywn Moller

Geology Faculty Datasets

In September 2016 NASA flew an interferometric synthetic aperture radar (GLISTIN) over most of the glacier-covered regions of the coterminous USA for the purpose of mapping the surface elevation of the glaciers. Where multiple passes were flown over the same ground track, the data were mosaiced together to improve data coverage and elevation accuracy. These data are to be used with elevations collected by past and future efforts to calculate volume change of glaciers.

The data were the basis for:

Glenn, Bryce Allen, "Assessing Airborne Radar to Map Glacier Elevations in Alpine Terrain Including Estimated Glacier Volume Change …

Astrocytic-Based Controller Shifts Epileptic Activity To The Chaotic State, Mojde Nahtani, Mehdi Siahi, Javad Razjouyan

Faculty, Staff and Students Publications

Introduction: Investigating an effective controller to shift hippocampal epileptic periodicity to normal chaotic behavior will be new hope for epilepsy treatment. Astrocytes nourish and protect neurons and maintain synaptic transmission and network activity. Therefore, this study explored the ameliorating effect of the astrocyte computational model on epileptic periodicity.

Methods: Modified Morris-Lecar equations were used to model the hippocampal CA3 network. Network inhibitory parameters were employed to generate oscillation-induced epileptiform periodicity. The astrocyte controller was based on a functional dynamic mathematical model of brain astrocytic cells.

Results: Results demonstrated that the synchronization of two neural networks shifted the brain's chaotic state …

Cup Is Essential For Oskar Mrna Translational Repression During Early Drosophila Oogenesis, Livia V. Bayer, Samantha Milano, Stephen K. Formel, Harpreet Kaur, Rishi Ravichandran, Juan A. Cambeiro, Lizaveta Slinko, Irina E. Catrina, Diana P. Bratu

Publications and Research

Study of the timing and location for mRNA translation across model systems has begun to shed light on molecular events fundamental to such processes as intercellular communication, morphogenesis, and body pattern formation. In D. melanogaster, the posterior mRNA determinant, oskar, is transcribed maternally but translated only when properly localized at the oocyte’s posterior cortex. Two effector proteins, Bruno1 and Cup, mediate steps of oskar mRNA regulation. The current model in the field identifies Bruno1 as necessary for Cup’s recruitment to oskar mRNA and indispensable for oskar’s translational repression. We now report that this Bruno1-Cup interaction leads …

Single Inclusive Hadron Production In Dis At Small X: Next To Leading Order Corrections, Filip Bergabo, Jamal Jalilian-Marian

Publications and Research

We calculate the one-loop corrections to single inclusive hadron production in Deep Inelastic Scattering (DIS) at small x in the forward rapidity region using the Color Glass Condensate formalism. We show that the divergent parts of the next to leading order (NLO) corrections either cancel among each other or lead to x (rapidity) evolution of the leading order (LO) dipole cross section according to the JIMWLK evolution equation and DGLAP evolution of the parton-hadron fragmentation function. The remaining finite parts constitute the NLO (α_s) corrections to the LO single inclusive hadron production cross section in DIS at …

Active Learning For Efficient Soil Monitoring In Large Terrain With Heterogeneous Sensor Network, Hui Chen, Ju Wang

Publications and Research

Soils are a complex ecosystem that provides critical services, such as growing food, supplying antibiotics, filtering wastes, and maintaining biodiversity; hence monitoring soil health and domestication is required for sustainable human development. Low-cost and high-resolution soil monitoring systems are challenging to design and build. Compounded by the sheer size of the monitoring area of interest and the variety of biological, chemical, and physical parameters to monitor, naive approaches to adding or scheduling more sensors will suffer from cost and scalability problems. We investigate a multi-robot sensing system integrated with an active learning-based predictive modeling technique. Taking advantage of advances in …

Molecular Mechanism Behind The Safe Immunostimulatory Effect Of Withania Somnifera, Kriti Kalpana, Shen Yap, Moriya Tsuji, Akira Kawamura

Publications and Research

Withania somnifera (L.) Dunal (family Solanaceae) is a medicinal plant known for, among many pharmacological properties, an immune boosting effect. Our recent study revealed that its key immunostimulatory factor is lipopolysaccharide of plant-associated bacteria. This is peculiar, because, although LPS can elicit protective immunity, it is an extremely potent pro-inflammatory toxin (endotoxin). However, W. somnifera is not associated with such toxicity. In fact, despite the presence of LPS, it does not trigger massive inflammatory responses in macrophages. To gain insights into the safe immunostimulatory effect of W. somnifera, we conducted a mechanistic study on its major phytochemical constituent, …

Structure–Activity Relationship Studies On 6-Chloro-1-Phenylbenzazepines Leads To The Identification Of A New Dopamine D1 Receptor Antagonist, Rajan Giri, Hari K. Namballa, Vishwashiv Emogaje, Wayne W. Harding

Publications and Research

The 1-phenylbenzazepine template has yielded a number of D1R-like ligands, which, though useful as pharmacological tools, have significant drawbacks in terms of selectivity versus D5R as well as pharmacokinetic behavior. A number of 1-phenylbenzazepines contain a 6-chloro functional group, but extensive SAR studies around the 6-chloro-1-phenylbenzazepine framework have not been reported in the literature. To further understand the tolerance of the 6-chloro-1-phenylbenzazepine template for various substituent groups towards affinity and selectivity at D1R, we synthesized two series of analogs with structural variations at the C-7, C-8, N-3, C-3′ and C-4′ positions. The series 2 analogs differed from …

Changes To Sea Surface Temperatures And Vertical Wind Shear And Their Influence On Tropical Cyclone Activity In The Caribbean And The Main Developing Region, Keneshia Hibbert, Equisha Glenn, Thomas M. Smith, Jorge E. González-Cruz

Publications and Research

Sea surface temperatures and vertical wind shear are essential to tropical cyclone formation. TCs need warm SSTs and low shear for genesis. Increasing SSTs and decreasing VWS influences storm development. This work analyzes SST and VWS trends for the Caribbean, surrounding region, and the Atlantic hurricane main developing region from 1982–2020. Storm intensity increases significantly during this period. Annual and seasonal trends show that regional SSTs in the MDR are warming annually at 0.0219 °C yr⁻¹ and, per season, 0.0280 °C yr⁻¹. Simultaneously, VWS decreases during the late rainfall season, at 0.056 m/s yr⁻¹ in the …

Ecological Niche Comparison Among Closely Related Tree Species Of Lauraceae Using Climatic And Edaphic Data, Laura J. Giraldo-Kalil, Gonzalo E. Pinilla Buitrago, Andrés Lira-Noriega, Francisco Lorea-Hernández, Juan Núñez-Farfán

Publications and Research

ABSTRACT:

Edaphic specialization is considered to promote ecological differentiation among closely related species of Damburneya (Lauraceae) occurring in sympatry. However, little is known about the effects of soil and other key environmental factors like climate on the ecological niche and distribution of these tree species. Here, we assessed the role of climate and soil on niche divergence and potential distribution of four Damburneya species whose distributions span Central America and Mexico. We performed ecological niche modeling with MaxEnt using three sets of environmental data: climatic-only, edaphic-only, and a combination of both, to characterize species niches and suitable distribution areas. Niche …

C-Glycopyranosyl Aldehydes: Emerging Chiral Synthons In Organic Synthesis, Sandeep Kumar, Vinod Khatri, Priyanka Mangla, Rajni Johar Chhatwal, Virinder S. Parmar, Ashok K. Prasad

Publications and Research

Herein, we have summarized the vast array of synthetic processes that have been developed for the synthesis of C-glycopyranosyl aldehydes and diverse C-glycoconjugates derived from them by covering the literature reported from 1979 to 2023. Notwithstanding its challenging chemistry, C-glycosides are considered stable pharmacophores and are used as important bioactive molecules. The discussed synthetic methodologies to access C-glycopyranosyl aldehydes take advantage of seven key intermediates, viz. allene, thiazole, dithiane, cyanide, alkene, and nitromethane. Furthermore, the integration of complex C-glycoconjugates derived from varied C-glycopyranosyl aldehydes involves nucleophilic addition/substitution, reduction, condensation, oxidation, cyclo condensation, coupling, and …

Hamiltonian Structure Of 2d Fluid Dynamics With Broken Parity, Gustavo Machado Monteiro, Alexander G. Abanov, Sriram Ganeshan

Publications and Research

Isotropic fluids in two spatial dimensions can break parity symmetry and sustain transverse stresses which do not lead to dissipation. Corresponding transport coefficients include odd viscosity, odd torque, and odd pressure. We consider an isotropic Galilean invariant fluid dynamics in the adiabatic regime with momentum and particle density conservation. We find conditions on transport coefficients that correspond to dissipationless and separately to Hamiltonian fluid dynamics. The restriction on the transport coefficients will help identify what kind of hydrodynamics can be obtained by coarse-graining a microscopic Hamiltonian system. Interestingly, not all parity-breaking transport coefficients lead to energy conservation and, generally, the …

Inclusive Random Sampling In Graphs And Networks, Yitzchak Novick, Amotz Bar-Noy

Publications and Research

It is often of interest to sample vertices from a graph with a bias towards higher-degree vertices. One well-known method, which we call random neighbor or RN, involves taking a vertex at random and exchanging it for one of its neighbors. Loosely inspired by the friendship paradox, the method is predicated on the fact that the expected degree of the neighbor is greater than or equal to the expected degree of the initial vertex. Another method that is actually perfectly analogous to the friendship paradox is random edge, or RE, where an edge is sampled at random, and then one …

Logic As Applied Mathematics — With Particular Application To The Notion Of Logical Form, Graham Priest

Publications and Research

The word ‘logic’ has many senses. Here we will understand it as meaning an account of what follows from what and why. With contemporary methodology, logic in this sense – though it may not always have been thought of in this way – is a branch of applied mathematics. This has various implications for how one understands a number of issues concerning validity. In this paper I will explain this perspective of logic, and explore some of its consequences with respect to the notion of logical form.

Quantity Of Questing Black-Legged Ticks And Associated Micro-Scale Environmental Data Collected From Four Suburban Parks Near New York City, Shipeng Sun, Chong Di, Li Li, Brian Sulkow, Weigang Qiu

Publications and Research

During 2017 and 2018, we collected the quantity of questing black-legged ticks (Ixodes scapularis), also known as deer ticks, in 124 sampling sites of 5m by 5m in four state parks—Caumsett State Historic Park, Connetquot River State Park, Rockefeller State Park, and Fire Island National Seashore—around New York City. The black-legged tick is the primary vector for the spirochete Borrelia burgdorferi, the pathogen of Lyme disease, in Northeastern United States. Using the flagging method, we collected and counted the numbers of adult and nymphal black-legged ticks at each site. Along with these quantities, we also recorded the …

Automated Morphological Phenotyping Using Learned Shape Descriptors And Functional Maps: A Novel Approach To Geometric Morphometrics, Oshane O. Thomas, Hongyu Shen, Ryan L. Raaum, William E. H. Harcourt-Smith, John D. Polk, Mark Hasegawa-Johnson

Publications and Research

The methods of geometric morphometrics are commonly used to quantify morphology in a broad range of biological sciences. The application of these methods to large datasets is constrained by manual landmark placement limiting the number of landmarks and introducing observer bias. To move the field forward, we need to automate morphological phenotyping in ways that capture comprehensive representations of morphological variation with minimal observer bias. Here, we present Morphological Variation Quantifier (morphVQ), a shape analysis pipeline for quantifying, analyzing, and exploring shape variation in the functional domain. morphVQ uses descriptor learning to estimate the functional correspondence between whole triangular meshes …

Adaptive Single Low-Light Image Enhancement By Fractional Stretching In Logarithmic Domain, Thaweesak Trongtirakul, Sos S. Agaian, Shiqian Wu

Publications and Research

Low-light image enhancement is a challenging task that aims to improve the visibility and quality of images captured in dark environments. However, existing methods often introduce undesirable artifacts such as color distortion, halo effects, blocking artifacts, and noise amplification. In this paper, we propose a novel method that overcomes these limitations by using the logarithmic domain fractional stretching approach to estimate the reflectance component of the image based on the improved Retinex theory. Moreover, we apply a simple adaptive gamma correction algorithm to the Lab color-space to adjust the brightness and saturation of the image. Our method effectively reduces the …

Fabrication And Errors In The Bibliographic Citations Generated By Chatgpt, William H. Walters, Esther Isabelle Wilder

Publications and Research

Although chatbots such as ChatGPT can facilitate cost-effective text generation and editing, factually incorrect responses (hallucinations) limit their utility. This study evaluates one particular type of hallucination: fabricated bibliographic citations that do not represent actual scholarly works. We used ChatGPT-3.5 and ChatGPT-4 to produce short literature reviews on 42 multidisciplinary topics, compiling data on the 636 bibliographic citations (references) found in the 84 papers. We then searched multiple databases and websites to determine the prevalence of fabricated citations, to identify errors in the citations to non-fabricated papers, and to evaluate adherence to APA citation format. Within this set of documents, …

Aligning Retrograde Nuclear Cluster Orbits With An Active Galactic Nucleus Accretion Disc, Syeda S. Nasim, Gaia Fabj, Freddy Caban, Amy Secunda, K. E. Saavik Ford, Barry Mckernan, Jillian M. Bellovary, Nathan W. C. Leigh, Wladimir Lyra

Publications and Research

Stars and stellar remnants orbiting a supermassive black hole (SMBH) can interact with an active galactic nucleus (AGN) disc. Over time, prograde orbiters (inclination i < 90°) decrease inclination, as well as semimajor axis (a) and eccentricity (e) until orbital alignment with the gas disc (‘disc capture’). Captured stellar-origin black holes (sBH) add to the embedded AGN population that drives sBH–sBH mergers detectable in gravitational waves using LIGO–Virgo–KAGRA or sBH–SMBH mergers detectable with Laser Interferometer Space Antenna. Captured stars can be tidally disrupted by sBH or the SMBH or rapidly grow into massive ‘immortal’ stars. Here, we investigate the behaviour of polar and retrograde orbiters …

Astrophysics With The Laser Interferometer Space Antenna, Pau Amaro-Seoane, Jeff Andrews, Manuel Arca Sedda, Abbas Askar, Quentin Baghi, Razvan Balasov, Imre Bartos, Simone S. Bavera, Jillian Bellovary, Christopher P. L. Berry, Emanuele Berti, Stefano Bianchi, Laura Blecha, Stéphane Blondin, Tamara Bogdanović, Samuel Boissier, Matteo Bonetti, Silvia Bonoli, Elisa Bortolas, Katelyn Breivik, Pedro R. Capelo, Laurentiu Caramete, Federico Cattorini, Maria Charisi, Sylvain Chaty, Xian Chen, Martyna Chruślińska, Alvin J. K. Chua, Ross Church, Monica Colpi, Daniel D’Orazio, Camilla Danielski, Melvyn B. Davies, Pratika Dayal, Alessandra De Rosa, Andrea Derdzinski, Kyriakos Destounis, Massimo Dotti, Ioana Duţan, Irina Dvorkin, Gaia Fabj, Thierry Foglizzo, Saavik Ford, Jean-Baptiste Fouvry, Alessia Franchini, Tassos Fragos, Chris Fryer, Massimo Gaspari, Davide Gerosa, Luca Graziani, Paul Groot, Melanie Habouzit, Daryl Haggard, Zoltan Haiman, Wen-Biao Han, Alina Istrate, Peter H. Johansson, Fazeel Mahmood Khan, Tomas Kimpson, Kostas Kokkotas, Albert Kong, Valeriya Korol, Kyle Kremer, Thomas Kupfer, Astrid Lamberts, Shane Larson, Mike Lau, Dongliang Liu, Nicole Lloyd-Ronning, Giuseppe Lodato, Alessandro Lupi, Chung-Pei Ma, Tomas Maccarone, Ilya Mandel, Alberto Mangiagli, Michela Mapelli, Stéphane Mathis, Lucio Mayer, Sean Mcgee, Barry Mckernan, M. Coleman Miller, David F. Mota, Matthew Mumpower, Syeda S. Nasim, Gijs Nelemans, Scott Noble, Fabio Pacucci, Francesca Panessa, Vasileios Paschalidis, Hugo Pfister, Delphine Porquet, John Quenby, Angelo Ricarte, Friedrich K. Röpke, John Regan, Stephan Rosswog, Ashley Ruiter, Milton Ruiz, Jessie Runnoe, Raffaella Schneider, Jeremy Schnittman, Amy Secunda, Alberto Sesana, Naoki Seto, Lijing Shao, Stuart Shapiro, Carlos Sopuerta, Nicholas C. Stone, Arthur Suvorov, Nicola Tamanini, Tomas Tamfal, Thomas Tauris, Karel Temmink, John Tomsick, Silvia Toonen, Alejandro Torres-Orjuela, Martina Toscani, Antonios Tsokaros, Caner Unal, Verónica Vázquez-Aceves, Rosa Valiante, Maurice Van Putten, Jan Van Roestel, Christian Vignali, Marta Volonteri, Kinwah Wu, Ziri Younsi, Shenghua Yu, Silvia Zane, Lorenz Zwick, Fabio Antonini, Vishal Baibhav, Enrico Barausse, Alexander Bonilla Rivera, Marica Branchesi, Graziella Branduardi-Raymont, Kevin Burdge, Srija Chakraborty, Jorge Cuadra, Kristen Dage, Benjamin Davis, Selma E. De Mink, Roberto Decarli, Daniela Doneva, Stephanie Escoffier, Poshak Gandhi, Francesco Haardt, Carlos O. Lousto, Samaya Nissanke, Jason Nordhaus, Richard O’Shaughnessy, Simon Portegies Zwart, Adam Pound, Fabian Schussler, Olga Sergijenko, Alessandro Spallicci, Daniele Vernieri, Alejandro Vigna-Gómez

Publications and Research

The Laser Interferometer Space Antenna (LISA) will be a transformative experiment for gravitational wave astronomy, and, as such, it will offer unique opportunities to address many key astrophysical questions in a completely novel way. The synergy with ground-based and space-born instruments in the electromagnetic domain, by enabling multi-messenger observations, will add further to the discovery potential of LISA. The next decade is crucial to prepare the astrophysical community for LISA’s first observations. This review outlines the extensive landscape of astrophysical theory, numerical simulations, and astronomical observations that are instrumental for modeling and interpreting the upcoming LISA datastream. To this aim, …

Feeling Analogue: Using Modular Synthesizers, Designing Synthesis Communities, Eliot Bates

Publications and Research

When Harald Bode nominally invented the modular synthesiser in 1960, it was not yet clear whether it was a musical instrument or a less-defined form of studio-sited audio technology (Subotnik 1970). Much of the technology, from the interface design to the specific parts, was shared with nonmusical test and measurement equipment. Sixty years later, hardware modular synthesis is used not just for musical creation but for noise, sound art and data sonification/visualization. Through an ethnographic study of the design and use of the Eurorack modular synthesis format, and of modular synthesis maker and user communities spread through North America, Europe …

Applying Single Cell Multi-Omic Analyses To Understand Treatment Resistance In Pediatric High Grade Glioma, Rebecca L Murdaugh, Jamie N Anastas

Faculty, Staff and Students Publications

Despite improvements in cancer patient outcomes seen in the past decade, tumor resistance to therapy remains a major impediment to achieving durable clinical responses. Intratumoral heterogeneity related to genetic, epigenetic, transcriptomic, proteomic, and metabolic differences between individual cancer cells has emerged as a driver of therapeutic resistance. This cell to cell heterogeneity can be assessed using single cell profiling technologies that enable the identification of tumor cell clones that exhibit similar defining features like specific mutations or patterns of DNA methylation. Single cell profiling of tumors before and after treatment can generate new insights into the cancer cell characteristics that …

Unequal Trust: Bottled Water Consumption, Distrust In Tap Water, And Economic And Racial Inequality In The United States, Daniel Jaffee

Sociology Faculty Publications and Presentations

Reviewing public health, nutrition, and social science literature, this article examines how bottled water consumption and spending in the United States differ along lines of race, ethnicity, and income, how these consumption patterns have changed in recent years, and how those shifts map onto perceptions of the safety and trustworthiness of tap water supplies, both before and since the Flint water disaster. It also addresses the differential impact of bottled water spending on household income. The findings challenge the truism that bottled water consumption is positively correlated with income, instead showing a bimodal racial and class consumption pattern that reflects …