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Effect Of Reduced Cardiomyocyte O-Glcnacylation On The Expression And Activity Of The Cardiac Voltage-Gated Sodium Channel, Chiagozie Dawn Bede Paul-Onyia

Browse all Theses and Dissertations

Abnormal glycosylation can impact cardiac proteins, affecting signaling, contraction, and metabolism, which leads to compromised cardiac function. O-GlcNAcylation, the only form of intracellular glycosylation, involves adding a single GlcNAc molecule to proteins via enzymes: O-GlcNAc Transferase (OGT) for addition and O-GlcNAcase (OGA) for removal. The Ednie/Bennett lab has previously demonstrated that in both chronic (OGT KO) and acute (OGT inhibition) models of reduced cardiomyocyte O-GlcNAcylation, a disruption of Ca2+ homeostasis occurs. This study delved into the cardiac voltage-gated sodium channel (NaV 1.5) in these models. NaV 1.5 expression was analyzed through western blotting and immunocytochemistry, while its functional activity was …

Novel Formulation Strategies With Hot-Melt Extrusion Technology To Address Physicochemical And Physiological Constraints For Improved Oral Drug Delivery, Sagar Narala

Electronic Theses and Dissertations

Most current active pharmaceutical ingredients (APIs) exhibit poor water solubility, necessitating higher doses or repeated administration. Numerous methods were explored to augment solubility, including but not limited to amorphous solid dispersions, cocrystals, salts, and nanoformulations. The hot-melt extrusion (HME) technique has gained immense popularity due to its solvent-free and continuous manufacturing capabilities, contributing to its increasing use to enhance solubility and bioavailability. In the first chapter, hydrochlorothiazide (BCS-IV class) cocrystals were produced using coformers such as nicotinamide (NIC), resorcinol (RSL), and catechol (CAT) through HME technology. The cocrystals were compared against liquid-assisted grinding (LAG) cocrystals and then analyzed by DSC, …

A Discrete Conley-Zehnder Index For Symplectic Polytopes, Yutian Yu

Electronic Theses and Dissertations

A Hamiltonian system is a dynamical system governed by Hamilton’s equations. Hamiltonian systems provide a framework for studying classical mechanics. One fundamental principle in Hamiltonian mechanics is the conservation of energy along the flow of the Hamiltonian vector field. The smooth hypersurface of a Hamiltonian function on a symplectic manifold has a contact structure, and the associated Reeb vector field is, up to a scale, the Hamiltonian vector field. We are interested in the non-smooth case and a symplectic polytope makes a good model to study.

In this dissertation, we study the Reeb dynamics on the boundary of a symplectic …

Investigating The Influences Of Summer Experiences On Students' Self-Efficacy In Stem, Olivia Palicki

Williams Honors College, Honors Research Projects

Improving high school students’ interest and confidence in STEM is a national priority. Educators and stakeholders in educational policy have pressed for increasing opportunities to engage students in authentic science experiences and focus on teaching 21st century skills. The purpose of this case study was to investigate how a summer research experience may have influenced high school students’ self-efficacy and career interests in STEM subjects and practices as well as identifying what students learned from their experience in the program. Pre/post program surveys were analyzed to measure change in student attitudes towards STEM and to capture students learning outcomes from …

Human Tracking Function For Robotic Dog, Andrew Sharkey

Williams Honors College, Honors Research Projects

With the increase the increase in automation and humans and robots working side by side, there is a need for a more organic way of controlling robots. The goal of this project is to create a control system for Boston dynamics robotic dog Spot that implements human tracking image software to follow humans using computer vision as well as using hand tracking image software to allow for control input through hand gestures.

Textural And Mineral Analysis Of Pegmatites From The Pala And Mesa Grande Districts In San Diego, California, Gabrielle Potter

Williams Honors College, Honors Research Projects

San Diego pegmatites of the Pala and Mesa Grande mining districts are world renowned for their gem-quality minerals and their Li-bearing mineral phases. Pegmatite genesis, especially in San Diego mines, has been a debated topic since the 1900’s (Morgan and London, 2012). Pegmatite genesis is caused by partial melting processes and fractional crystallization that form granitic melts with high concentrations of rare earth elements (REE), such as lithium. Assessing the exact mineralogy and determining the overall textures can provide insight into the crystallization history of pegmatites. In the San Diego pegmatites, lithium-bearing phases, such as lepidolite and pink elbaite (a …

The Affect Of Dha Concentration On Lipid Membrane Fluidity, Elise Rezabeck

Williams Honors College, Honors Research Projects

My proposed project will be creating large unilaminar vesicles with varying concentrations of DHA in the vesicles. The diffusion in and out of these vesicles will be tracked by using singular lipid molecules. These singular lipid molecules will be tagged with fluorescence and viewed using an internal reflection fluorescence microscope. The data collected over the course of this project will then be analyzed using Matlab. The result of the project will be to find the specific lipid diffusion constant of these unilaminar vesicles. The relationship between the concentration of DHA and lipid diffusion and membrane fluidity will be found as …

Global Minimum Search For The Largest Ge Cage Stabilized By A Single Interstitial Metal Atom, Alexis Kiefer

Williams Honors College, Honors Research Projects

Recent joint experimental and theoretical studies showed that the largest Ge cage-like cluster features 14 Ge atoms that encapsulate a single transition metal atom in the [Nb@Ge₁₄]^3- cluster. The next larger experimentally confirmed Ge cluster exhibiting a cage-like geometry was found to be viable only when stabilized by two transition metal atoms in the [Co₂@Ge₁₆]^4- cluster. So, as of now, it is not clear whether a cage-like cluster made out of 15 Ge atom stabilized by a single transition metal is viable. Hence, the aim of this project is to find the …

Intergranular And Pitting Corrosion Mechanisms Of Sensitized Aluminum Alloy Aa5083, Clayton Egleston

Williams Honors College, Honors Research Projects

The motivation and objectives of this project is to examine the mechanisms of intergranular corrosion (IGC) and pitting corrosion of sensitized AA5083. In this regard, different characterization techniques were used, including optical analysis of microstructure, cyclic potentiodynamic polarization with Tafel fitting, electrochemical impedance spectroscopy with electrical equivalent circuit (EEC) fitting, and potentiostatic current transient monitoring. The transition from IGC to pitting corrosion occurs when the grain boundaries become saturated with the β-phase (Mg₂Al₃). It was found that AA5083 becomes more vulnerable to pitting corrosion as the degree of sensitization increases.

Growing In Stem: Hands-On Education Via Tower Gardening, Jeffrey A. Nowak, Shelby Johnston-Werling

Indiana STEM Education Conference

Sole use of a textbook as the primary source of learning in the middle school setting has been linked to potentially limit students’ conceptual understanding of complex content (Driscoll et al., 1994), while the positive impact of hands-on learning has been well documented (Ekwueme et al., 2015; Satterthwait, 2010). Ideally, when a textbook is used in conjunction with content applied in a hands-on manner, student engagement and understanding of standards-based content are increased. In a grant funded collaboration between the Northeast Indiana STEM Education Resource Center housed at Purdue University Fort Wayne and an East Allen Community Schools middle school …

Students' Perspectives Of Thinking With Algebra, David Feikes, William S. Walker Iii, Natalie Mcgathey, Bir Kafle, Brandon H. Sorge

Indiana STEM Education Conference

Thinking With Algebra (TWA) is a curriculum development project for college students needing introductory/intermediate algebra. Unique guiding principles of the project are a focus on algebraic structure, mixed review, equity, and a classroom approach emphasizing small-group work and whole-class discussion (Feikes et al., 2022). Results are derived from a survey given to one class of fifteen students taking an intermediate algebra summer course. The paper shares both Likert and open-ended responses. Data demonstrates that the students believed that the TWA curriculum was beneficial.

Improving Developers' Understanding Of Regex Denial Of Service Tools Through Anti-Patterns And Fix Strategies, Sk Adnan Hassan, Zainab Aamir, Dongyoon Lee, James C. Davis, Francisco Servant

Department of Electrical and Computer Engineering Faculty Publications

Regular expressions are used for diverse purposes, including input validation and firewalls. Unfortunately, they can also lead to a security vulnerability called ReDoS (Regular Expression Denial of Service), caused by a super-linear worst-case execution time during regex matching. Due to the severity and prevalence of ReDoS, past work proposed automatic tools to detect and fix regexes. Although these tools were evaluated in automatic experiments, their usability has not yet been studied; usability has not been a focus of prior work. Our insight is that the usability of existing tools to detect and fix regexes will improve if we complement them …

An Empirical Study Of Pre-Trained Model Reuse In The Hugging Face Deep Learning Model Registry, Wenxin Jiang, Nicholas Synovic, Matt Hyatt, Taylor R. Schorlemmer, Rohan Sethi, Yung-Hsiang Lu, George K. Thiruvathukal, James C. Davis

Department of Electrical and Computer Engineering Faculty Publications

Deep Neural Networks (DNNs) are being adopted as components in software systems. Creating and specializing DNNs from scratch has grown increasingly difficult as state-of-the-art architectures grow more complex. Following the path of traditional software engineering, machine learning engineers have begun to reuse large-scale pre-trained models (PTMs) and fine-tune these models for downstream tasks. Prior works have studied reuse practices for traditional software packages to guide software engineers towards better package maintenance and dependency management. We lack a similar foundation of knowledge to guide behaviors in pre-trained model ecosystems.

In this work, we present the first empirical investigation of PTM reuse. …

On The Fast Prediction Of The Aerodynamic Performance Of Electronics Cooling Fans Considering The Effect Of Tip Clearance, W. Zhao, S. Wasala, T. Persoons

CTRC Research Publications

No abstract provided.

Usability Evaluation Of A Community Pharmacy Health Information Exchange Interface Prototype, Katelyn N. Hettinger, Margie E. Snyder, Omolola A. Adeoye-Olatunde, Alissa L. Russ-Jara

Department of Pharmacy Practice Faculty Publications

Objective
Few community pharmacies have access to health information exchange (HIE) data. We conducted a first-of-its-kind usability evaluation of an HIE interface prototype (referred to throughout as the “HIE-Pioneer mock-up”) developed with pharmacists and pharmacy technicians to aid future implementation in community pharmacies.

Methods
Community pharmacists and pharmacy technicians were recruited to complete usability evaluations with the HIE-Pioneer mock-up. Each usability evaluation lasted up to 60 minutes. System usability scale (SUS) scores were collected from each participant following each usability evaluation session and summarized with descriptive statistics. Usability evaluation videos were reviewed for common usability attributes, such as the impact …

Teachers' Instructional Strategies In Integrated Stem Education, Yousef Alrashdi, Paul A. Asunda

Indiana STEM Education Conference

Integrated Science, Technology, Engineering, and Mathematics (iSTEM) education has been regarded as a model that provides students with skills necessary for future careers and enhances the economy of nations. Although there is a considerable body of research on the effective educational approaches in iSTEM education including problem-based and project-based learning, the ways teachers implement these approaches remain ambiguous due to a paucity of consensus about how to effectively use iSTEM approaches in classrooms (Thibaut et al., 2018). Additionally, there is a need for further investigation to understand teachers’ instructional strategies and practices in iSTEM education (Bush, 2019). To fulfill this …

Integrated Stem: Impact Of Engineering Design And Computer Science In Stem Labs, Jason Morphew, Ruben Lopez, Amir Bralin, Ravishankar Chatta Subramaniam, Sanjay Rebello, Carina Rebello

Indiana STEM Education Conference

By integrating physics laboratories with engineering design and computer science, students apply physics principles to ill-structured and complex problems, engage in knowledge transfer, and gain interest in STEM. The introductory physics labs at Purdue have been updated to include engineering design and computer science principles that ground physics in authentic problems. Integrated labs have been evaluated using student perception post-surveys, student course performance, interviews, and case-study observations. Preliminary results indicate that integrated physics labs promote transfer, enhanced metacognitive skills, student interest, and motivation.

Achieving Equity And Excellence: A Multilevel Modeling Of The Relationships Among School Climate, Students’ Motivation, And Achievement With Timss 2019, Yao Yang, Tugce Karatas, Tybresha Ebony Glass

Indiana STEM Education Conference

This study examined the effects of students’ motivational factors and school climate factors on eighth-grade math and science achievement in the U.S. using data from the 2019 Trends in International Mathematics and Science Study (TIMSS). Two-level, cross-sectional hierarchical linear models were developed to analyze the data. The results showed that there was a significant variation in math and science achievement across schools. Only students’ confidence in math and school SES had statistically significant effects on students’ math achievement. School location and school SES had statistically significant effects on science achievement.

Innovation In Quantum Pedagogy, Application, And Its Relation To Culture (Iqparc), Zeynep Gonca Akdemir, Dongyang Li, Muhsin Menekse, Mahdi Hosseini, Erica W. Carlson, Nicholas Dang

Indiana STEM Education Conference

Innovation in Quantum Pedagogy, Application, and its Relation to Culture (IQ-PARC) is a team of Purdue faculty, graduate, and undergraduate students who collaborate and work for the National Defense Education Program (NDEP) for Science, Technology, Engineering, and Mathematics (STEM) education, outreach, and workforce initiative programs. We promote a STEM-literate workforce by providing learning opportunities for youth to understand basic principles and applications of quantum concepts through a variety of both face-to-face and online activities. This research brief describes accomplished tasks in the K-12 education space (e.g., quantum-infused middle school curriculum unit) and shares upcoming plans within the project timeline.

Teachers' Beliefs As A Tool To Extend The Cognitive Equity Concept, Ana-Maria Haiduc, Rose Mbewe, Signe E. Kastberg

Indiana STEM Education Conference

This research aims to extend the framing of the cognitive equity concept in teaching mathematics during the enacted phase of the curriculum beyond race and culture. Cognitive equity characterizes actions of teachers and curricula makers toward valuing differences in cognitive processes. Since beliefs influence teachers' actions, we investigate their ideas about valuing students' unique mathematical cognitive processes. Framing cognitive equity in teaching mathematics contributes to discovering teachers' equitable practices, thus revealing teachers' ways of making more inclusive cognitive curricular decisions. Future research could focus on framing cognitive equity in learning mathematics within the intended and implemented phase of the curriculum.

Thinking With Algebra: Two Professors' Perspectives, Natalie Mcgathey, Bir Kafle, David Feikes

Indiana STEM Education Conference

This research brief will share insights from using the curriculum, Thinking With Algebra (TWA), a National Science Foundation Project (DUE 2021414). The focus will be on the value of using this curriculum when working specifically with students who have taken Algebra I and Algebra II in high school, but were not prepared for college algebra or precalculus. This curriculum is specifically designed for STEM-track students who place below the level of college algebra when they enter college. The authors have found that TWA helps instructors honor the mathematical knowledge and ideas that students bring into the classroom. The curriculum units …

Investigating Elementary Teachers’ Use Of Mathematics Curriculum Materials, Jueqing Li, Doris Fulwider, Jill Newton

Indiana STEM Education Conference

Investigating Elementary Teachers’ Use of Mathematics Curriculum Materials is a collaborative research project across four universities. The primary goal of the project is to explore teachers’ use of mathematics curricular materials in the context of the proliferation of online resources and the COVID-19 pandemic, with a focus on curricular coherence, teacher autonomy, and the use of teacher-developed curriculum from sites such as Teachers-Pay-Teachers and Pinterest. We used individual and focus group teacher interviews at several schools representing diverse curricular contexts to explore both the quantitative and qualitative aspects of the teachers’ mathematics curricular decision making. Findings from this study highlight …

Developing Sustainability Related Attitudes And 21st Century Skills Through Informal Learning Opportunities, Shamila Janakiraman

Indiana STEM Education Conference

Informal learning environments, like libraries and museums, are known to improve student achievement and motivation (Bartels 2001). A meta-analysis reports on the strong positive effects of after-school programs on feelings and attitudes and school performance (Durlak et al, 2007). When working on after-school programs, middle and high school students may develop skills like communication, collaboration, creativity, critical thinking, information literacy, and digital literacy. Such a program was offered by a 501c(3) organization as an informal learning opportunity. As part of this program, high school student volunteers living in the United States (US) designed and delivered learning experiences for elementary and …

Studies On Non-Transition Metal Substitution To Ab2 Metal Hydride Alloys For Battery Application, Shiuan Chang

Wayne State University Dissertations

Nowadays, multiphase transition metal-based AB2 metal hydride alloys and the rare-earth metal-based AB5 alloys (currently used in consumer NiMH batteries) are used as negative electrodes in NiMH batteries. It is of great interest to explore the possibility of significantly improving NiMH battery performance to compete with Li-ion batteries. In this area, the effect of dopant elements from Group-IA, -IIA, -IIIA non-transition metal family has not been thoroughly studied. In this study, lithium, magnesium, and boron (a metalloid considered metal in this study) were chosen as modifiers in the C14-phase predominant AB2 alloy by different dopant concentrations and synthesis methods, doping …

Improving Lidar Fidelity For Hd Mapping Using Pattern Transplanting And Temporal Infill, Micah Bojrab

Wayne State University Dissertations

High Definition (HD) Mapping for Autonomous Driving creates an easily accessible wealth of information to confirm and enrich feedback from on-vehicle sensors. HD Maps built offline generally use dedicated ground collection vehicles equipped with high-cost, survey-grade LiDAR to accurately map a vehicle's areas of operation. We focus our work on controlled-access, divided highways characterized by wide roadways that require complex permutations to cover all directions of travel and access ramps. We study two common issues when collecting this road class that cause low-fidelity (LF) point clouds for HD Maps. First, aerial collection covers all directions and all ramps in a …

Sensemaking Of Michigan's Read By Grade Three Law, Amy Catherine Hawtin

Wayne State University Dissertations

Research suggests that school leaders’ understanding and process of making sense of educational reform policies and/or laws is shaped by social, organizational, individual factors. This understanding can impact how a school leader understands and interprets the law/policy and ultimately may impact implementation actions. In 2016, Michigan’s Read by Grade Three law was enacted into law, which requires districts to identify struggling readers and provide tiered reading intervention for those students requiring additional support. Furthermore, the law also outlines mandatory eligible retention for students achieving below the pre-determined cut-score on the annually administered Michigan Student Test of Educational Progress (M STEP) …

Predictable Dnn Inference For Autonomous Driving, Liangkai Liu

Wayne State University Dissertations

Deep neural networks (DNNs) are widely used in autonomous driving due to their high accuracy for perception, decision, and control. Predictability of the perception module is essential for the AV's safety. Predictability generally consists of two aspects: temporal and functional. Temporal aspects mean the task should be finished before the deadline. Functional aspects mean the task should make correct decisions. However, non-negligible time and performance variations are observed in DNN inference. Current DNN inference studies either ignore the variation issue or rely on the scheduler or the algorithm itself to handle it. None of the current work explains the roots …

How Rocks Rock: The Processes That Shape Our World, Jennifer Harrison

Lesson Plans

Have you ever thought about how the rocks in your driveway formed? Or the sand on your beach? How about the diamond in a ring or the charcoal in a grill?

All earthen material is subject to forces that impact its properties, from where we find it, how its structure is made and how it behaves under external pressures. Rocks are defined as any inorganic material found in the natural world (meaning not living material). There are 3 types of rock, and where and how they form is important in their classifications. They are subject to geological processes as well …

Examining K-12 School Leadership Through A Complexity Theory Lens, Mandi Lehnherr

Theses and Dissertations

Observing the connection between complexity theory and the K-12 education field, I conducted an extensive literature review to discover much research had already been undertaken. However, given the pervasive, wicked problems that still exist, there may be gaps in the operationalization of the findings. The purpose of this research is to determine how school leaders understand the complexity of their school system and if examining school leadership from a complexity lens may uncover practices that could create more effective school operations in dynamic environments. Ten school principals and leaders were interviewed. Five major themes were derived from the data: a) …

Molecular Dynamics Simulations For The Mechanical Behavior Of Alpha Quartz With Void Defects Under Tension, Yu Jia

Electronic Theses and Dissertations

The structural and mechanical properties of void-free and single-void α-quartz were investigated using MD simulations with three different interatomic potentials (BKS, Vashishta and Tersoff). Two distinct ensembles, NVT and NPT, were separately applied to investigate the tensile response of α-quartz under uniaxial strain and uniaxial stress states. A comprehensive comparison among different potentials, as well as comparison with currently available experiments, has been made. The BKS and Vashishta potentials accurately predicted the structural properties of void-free α-quartz, while the Tersoff potential was deviated significantly from the experimental data. Under tension, the BKS did a better description for the mechanical performance …