Digital Commons Network^™

Covid-19 Vaccination, Acceptance, Safety, And Side-Effects In European Patients With Severe Asthma, Apostolos Bossios, Alison M. Bacon, Katrien Eger

School of Psychology

Background Vaccination is vital for achieving population immunity to severe acute respiratory syndrome coronavirus 2, but vaccination hesitancy presents a threat to achieving widespread immunity. Vaccine acceptance in chronic potentially immunosuppressed patients is largely unclear, especially in patients with asthma. The aim of this study was to investigate the vaccination experience in people with severe asthma. Methods Questionnaires about vaccination beliefs (including the Vaccination Attitudes Examination (VAX) scale, a measure of vaccination hesitancy-related beliefs), vaccination side-effects, asthma control and overall safety perceptions following coronavirus disease 2019 (COVID-19) vaccination were sent to patients with severe asthma in 12 European countries between …

Pulmonary Specialist-Supported Health Coaching Delivered By Lay Personnel Improves Receipt Of Quality Care For Chronic Obstructive Pulmonary Disease: A Randomized Controlled Trial, Rachel Willard-Grace, Danielle Hessler, Beatrice Huang, Denise Devore, Chris Chirinos, Jessica Wolf, Devon Low, Chris Garvey, Doranne Donesky, Stephanie Tsao, David H. Thom, George Su

Journal of Patient-Centered Research and Reviews

Purpose: Half of people living with chronic obstructive pulmonary disease (COPD) do not receive high-quality, evidenced-based care as described in international guidelines. We conducted secondary data analysis of a previously published study to assess the ability of a model of lay health coaching to improve provision of guideline-based care in a primary care setting.

Methods: As part of a randomized controlled trial, we recruited English- and Spanish-speaking patients with moderate to severe COPD from primary care clinics serving a low-income, predominantly African American population. Participants were randomized to receive usual care or 9 months of health coaching from primary care …

Optimizing Antibiotic Durations Of Therapy In Pediatric Community-Acquired Pneumonia, Gregory Cook, Shubho Sarkar

School of Medicine Faculty Publications

Infectious Diseases Week, IDWeek 2023, October 11-15, 2023, Boston, MA

Promising Changes In Antibiotic Utilization Associated With Implementation Of Rapid Multiplex Polymerase Chain Reaction Testing For Bloodstream Infection, Tat Yau, Michelle Blyth, Julio E. Figueroa Ii

School of Medicine Faculty Publications

Infectious Diseases Week, IDWeek 2023, October 11-15, 2023, Boston, MA

One Vs Three Weekly Doses Of Benzathine Penicillin G For Treatment Of Early Syphilis In Persons With And Without Hiv: A Multicenter Randomized Controlled Trial (Rct), Edward W. Hook, Kimberly Workowski, Jodie A. Dionne, Candice J. Mcneil, Stephanie N. Taylor, Batteiger Teresa, Julia C. Dombrowski, Kenneth H. Mayer, Arlene C. Seña, Harold C. Wiesenfeld, Charlotte Perlowski, Lori Newman, Chunming Zhu, Jorge E. Mejia-Galvis

School of Medicine Faculty Publications

Infectious Diseases Week, IDWeek 2023, October 11-15, 2023, Boston, MA

Compliance With Human Papillomavirus Vaccination At The Hiv Outpatient Program In New Orleans, Louisiana, Tat Yau, Maria Frontini, Michael Hagensee

School of Medicine Faculty Publications

Infectious Diseases Week, IDWeek 2023, October 11 - 15, 2023, Boston, MA

Weight Gain And Weight Loss Attempts Among People With Hiv(Pwh) In Louisiana, Lauren Richey, Jonathan Schroeder, Kyle Mistretta, Hui-Yi Lin, Connie Arnold, David Welsh, John Apolzan

School of Medicine Faculty Publications

Infectious Diseases Week, IDWeek 2023, October 11 - 15, 2023, Boston, MA

A Preliminary Analysis Of Vaginal Microbial Changes Prior To Incident Bacterial Vaginosis As Determined By Qpcr And Inferred Absolute Abundance, Jacob H. Elnaggar, Christopher M. Taylor, Caleb M. Ardizzone, Kristal J. Aaron, Isaac C. Eastlund, Keonte J. Graves, Meng Luo, Alison J. Quayle, Nuno Cerca, Christina A. Muzny

School of Medicine Faculty Publications

Infectious Diseases Week, IDWeek 2023, October 11 - 15, 2023, Boston, MA

Amphibian Diversity Across Three Adjacent Ecosystems In Área De Conservación Guanacaste, Costa Rica, Alex W. Edwards, Xavier A. Harrison, M. Alex Smith, Mm Chavarria, Mahmood Sasa, Daniel H. Janzen, Winnie Hallwachs, Gerardo Chaves, R Fernandez, Caroline Palmer, Chloe Wilson, Alexandra North, Robert Puschendorf

School of Biological and Marine Sciences

Amphibians are the most threatened species-rich vertebrate group, with species extinctions and population declines occurring globally, even in protected and seemingly pristine habitats. These ‘enigmatic declines’ are generated by climate change and infectious diseases. However, the consequences of these declines are undocumented as no baseline ecological data exists for most affected areas. Like other neotropical countries, Costa Rica, including Área de Conservación Guanacaste (ACG) in north-western Costa Rica, experienced rapid amphibian population declines and apparent extinctions during the past three decades. To delineate amphibian diversity patterns within ACG, a large-scale comparison of multiple sites and habitats was conducted. Distance and …

Nurse Leader Burnout: The Impact From The Covid-19 Pandemic, Chelsey P. Hinrichs, Brittany Huneke, Ali Marty Rodningen

Nursing Masters Papers

Problem: Levels of burnout in nurse leaders have elevated at alarming rates throughout the COVID-19 pandemic.

Research Purpose: The purpose of this secondary analysis is to examine a.) prevalence of burnout felt by nurse leaders b.) drivers contributing to burnout for nurse leaders c.) outcomes related to nurse leader burnout and d.) workplace strategies that can be implemented to assist in decreasing burnout felt by nurse leaders.

Theoretical Model: The Conservation of Resources (COR) theory was applied to drive this study. This theory was chosen due to its connection to burnout and its direct relationship to COR theory resources. …

Point Of Care Testing: Best Practice Toolkit For Improving Access To Point Of Care Testing In Mobile Medicine, Michaela Gist

Student Scholarly Projects

Practice Problem: Healthcare for persons experiencing homelessness (PEH) is a complex issue. Chronic and communicable diseases are disproportionately represented within this population. Healthcare spending is 2.5 times more costly in comparison to those who have not experienced homelessness. Although mobile health clinics aim to reduce the concerns with access to care, they do not eliminate barriers if the appropriate tests are not immediately available.

PICO: In the homeless population treated in mobile medicine (P), what is the effect of point of care testing (I) on turnaround time (O) compared with outside laboratory testing (C)?

Evidence: Critical analysis of the literature …

Molecular Species Delimitation Of Marine Trematodes Over Wide Geographical Ranges: Schikhobalotrema Spp. (Digenea: Haplosplanchnidae) In Needlefishes (Belonidae) From The Pacific Ocean And Gulf Of Mexico, Gerardo Pérez-Ponce De León, Brenda Solórzano-García, Daniel C. Huston, Berenit Mendoza-Garfias, Jhonatan Cabañas-Granillo, Scott C. Cutmore, Thomas H. Cribb

Harold W. Manter Laboratory of Parasitology: Library Materials

Geographical distribution plays a major role in our understanding of marine biodiversity. Some marine fish trematodes have been shown to have highly restricted geographical distributions, while some are known to occur over very wide ranges; however, very few of these wide distributions have been demonstrated genetically. Here, we analyse species of the genus Schikhobalotrema (Haplosplanchnidae) parasitizing beloniforms from the tropical west Pacific, the eastern Pacific and the Gulf of Mexico (GoM). We test the boundaries of these trematodes by integrating molecular and morphological data, host association, habitat of the hosts and geographical distribution, following a recently proposed and standardized delineation …

2023-November-24-Yao Named Quillen College Of Medicine’S Dishner Chair Of Excellence.Pdf, University Marketing And Communication, East Tennessee State University

ETSU News

Dr. Zhi Q. Yao, division chief of research and director of East Tennessee State University’s Center of Excellence in HIV/AIDS in the Quillen College of Medicine, has been named the college’s Paul Dishner Chair of Excellence in Medicine.

Established in 1989, the primary focus of the Dishner Chair of Excellence in Medicine is to enhance research efforts in the Quillen College of Medicine.

He is well-suited for the task.

During his time at ETSU, Yao has brought more than $10 million in grant funding for his research either as the principal or co-principal investigator on numerous research projects and …

Chimeric Antigen Receptor T Cells To Target Cd79b In B-Ceall Lymphomas, Fuliang Chu, Jingjing Cao, Jingwei Liu, Haopeng Yang, Timothy J Davis, Shao-Qing Kuang, Xiaoyun Cheng, Zheng Zhang, Swathi Karri, Long T Vien, Laura Bover, Ryan Sun, Francisco Vega, Michael Green, Richard Eric Davis, Sattva S Neelapu

Faculty, Staff and Student Publications

BACKGROUND: Chimeric antigen receptor (CAR) T cells targeting CD19 mediate potent and durable effects in B-cell malignancies. However, antigen loss or downregulation is a frequent cause of resistance. Here, we report development of a novel CAR T-cell therapy product to target CD79b, a pan B-cell antigen, widely expressed in most B-cell lymphomas.

METHODS: We generated a novel anti-CD79b monoclonal antibody by hybridoma method. The specificity of the antibody was determined by testing against isogenic cell lines with human CD79b knock-in or knock-out. A single-chain variable fragment derived from the monoclonal antibody was used to make a panel of CD79b-targeting CAR …

Effects Of Water Access On Childhood Linear Growth In Zimbabwe, Robert Ntozini

Walden Dissertations and Doctoral Studies

No abstract provided.

Exploring Alternative Treatment Choices For Multidrug-Resistant Clinical Strains Of Helicobacter Pylori In Mongolia, Ayush Khangai, Batsaikhan Saruuljavkhlan, Dashdorj Azzaya, Boldbaatar Gantuya, Khasag Oyuntsetseg, Junko Akada, Takashi Matsumoto, Yoshio Yamaoka

Faculty, Staff and Students Publications

Helicobacter pylori is a pathogen related to severe diseases such as gastric cancer; because of rising antimicrobial-resistant strains, failure to eradicate H. pylori with antibiotics has increased worldwide. Multidrug-resistant H. pylori and gastric cancer is common in Mongolia; therefore, we aimed to explore alternative antimicrobial treatments and the genomes of resistant strains in this country. A total of 361 H. pylori strains isolated from patients in Mongolia were considered. Minimal inhibitory concentrations for two fluoroquinolones (ciprofloxacin and moxifloxacin), rifabutin, and furazolidone were determined via two-fold agar dilution. Genomic mutations in antibiotic-resistant strains were identified by next-generation sequencing using the Illumina …

Sexual Identity And Sexual Behavioral Risks Among Black Men In The United States, Darnell Winston Walker

Walden Dissertations and Doctoral Studies

No abstract provided.

Lactic Acid Bacterial Surface Display Of Scytovirin Inhibitors For Anti-Ebolavirus Infection, Joshua Wiggins, Ngan Nguyen, Wenzhong Wei, Leah Liu Wang, Haley Hollingsead Olson, Shi-Hua Xiang

Nebraska Center for Virology: Faculty Publications

Scytovirin (SVN) is a lectin from cyanobacteria which has a strong inhibitory activity against Ebola virus infection. We engineered scytovirin as the inhibitor for surface display of lactic acid bacteria to block Ebola virus infection. Two different bacterial strains (Lactobacillus casei and Lactococcus lactis) were successfully engineered for scytovirin expression on the bacterial surface. These bacteria were found to be effective at neutralizing pseudotyped Ebolavirus in a cell-based assay. This approach can be utilized for prophylactic prevention, as well as for treatment. Since lactic acid bacteria can colonize the human body, a long-term efficacy could be achieved. Furthermore, …

Isolated Small Airways Obstruction Predicts Future Chronic Airflow Obstruction: A Multinational Longitudinal Study, Ben Knox Brown, James Potts, Valentina Quintero Santofimio, Cosetta Minelli, Jaymini Patel, Peter Gj Burney, Andre Fs Amaral, Najlaa Mohammed Abass, Dhiraj Agarwal, Asaad A. Nafees

Community Health Sciences

Background: Chronic airflow obstruction is a key characteristic of chronic obstructive pulmonary disease. We investigated whether isolated small airways obstruction is associated with chronic airflow obstruction later in life.
Methods: We used longitudinal data from 3957 participants of the multinational Burden of Obstructive Lung Disease study. We defined isolated small airways obstruction using the prebronchodilator mean forced expiratory flow rate between 25% and 75% of the forced vital capacity (FVC) (FEF25-75) if a result was less than the lower limit of normal.
Results: Median follow-up time was 8.3 years. Chronic airflow obstruction was more likely to develop in participants with …

Antimicrobial Resistance In Streptococcus Pneumoniae: A Retrospective Analysis Of Emerging Trends In The United Arab Emirates From 2010 To 2021, Abiola Senok, Jens Thomsen, Najiba M. Abdulrazzaq, The Uae Amr Surveillance Consortium, Godfred Antony Menezes, Carole Ayoub Moubareck, Dean Everett

All Works

Although pneumococcal conjugate vaccines (PCV) have been effective in reducing the burden of Streptococcus pneumoniae infections, there is a paucity of data on the relationship with antimicrobial resistance (AMR) trends in the Arabian Gulf region. This study was carried out to assess S. pneumoniae resistance trends in the United Arab Emirates (UAE) where PCV-13 vaccination was introduced in 2011. Retrospective analysis of S. pneumoniae demographic and microbiological data collected as part of the national AMR surveillance program from 2010 to 2021 was carried out. A survey of reporting sites and hand searching of annual reports of local health authorities was …

Intelligent Healthcare: Evaluation Potential Implications Of Metaverse In Healthcare Based On Mathematical Decision-Making Framework, Ibrahim Elhenawy, Sara Fawaz Al-Baker, Mona Mohamed

Neutrosophic Systems with Applications

The Metaverse has the ability to restructure and change the manner in which individuals connect with one another as well as the activities that they carry out on a daily basis. One definition of a Metaverse describes it as "a virtual, digital, and three-dimensional universe formed by the integration of various cutting-edge technologies and virtual places." In this piece, we will explore the potential applications of the Metaverse in the medical field. Our conversations on the notion of the Metaverse and the primary technologies that make it possible are both thought-provoking and in-depth. In this article, we study and analyze …

Evaluation Of Fatty Acid Coated Hydroxyapatite For Biofilm-Associated Infection Prevention Following Dental Implantation, Emily Coleman Montgomery

Electronic Theses and Dissertations Archive

Infections are a common post-operative ailment for patients who have received a dental implant or biomedical device. These infections can be further complicated with biofilm development, leading to systemic infection or antibiotic resistance. Local drug delivery has recently increased in popularity due to its advantages in treating and preventing infection during wound healing while avoiding the common side effects of systemic drugs. Local drug delivery systems also have advantages for complex wounds, especially those with local vasculature damage. Hydroxyapatite is a natural bioceramic that can be used as a local delivery system due to its biocompatibility and remineralization potential. Previous …

Chronic Disease And The Inflammatory Body Burden: Social And Environmental Factors And Implications For Longevity, Catherine L. Zeman, Junu Shrestha, Raihan Khan, Ashley N. Oginz Wilson, Lisa A. Beltz

Department of Health Sciences - Faculty Scholarship

Everyday our body’s immune and detoxification systems are working to protect us from pathogens, cancerous cells, foreign substances, and chemical exposures. Declining trends in per capita longevity in the US suggest that these systems are being stressed beyond their natural resiliency. Several of these trends are discussed in light of funding for preventive vs. illness care. The authors then use a systems and interdisciplinary approach to introduce the immunobiological and biotransformation systems, and the concept of the exposome for those unfamiliar. The science of the immune and detoxification systems is explored considering the idea of chronic low-level inflammation. Additionally, new …

The Implications Of Ferroptosis In Antibiotic Resistance, Marysol Hohl

Senior Honors Theses

Bacterial infections in the United States are becoming increasingly resistant to existing antibiotic treatments. Due to projected increases in resistance and the recent decrease in novel antibacterials, experts have determined that the United States is in the “post-antibiotic era.” The scientific community has failed to resolve resistance despite the continual discovery of new antibiotic compounds. In the past decade, a novel form of cell death called ferroptosis has been implicated in antibiotic treatment by employing the use of nanotechnology. This literature review will describe the problem of bacterial resistance and demonstrate how current research is pioneering a new age of …

Stratification Of Risk For Emergent Intracranial Abnormalities In Children With Headaches: A Pediatric Emergency Care Applied Research Network (Pecarn) Study Protocol, Daniel S Tsze, Nathan Kuppermann, T Charles Casper, Bradley J Barney, Lawrence P Richer, Danica B Liberman, Pamela J Okada, Claudia R Morris, Sage R Myers, Jane K Soung, Rakesh D Mistry, Lynn Babcock, Sandra P Spencer, Michael D Johnson, Eileen J Klein, Kimberly S Quayle, Dale W Steele, Andrea T Cruz, Alexander J Rogers, Danny G Thomas, Jacqueline M Grupp-Phelan, Tiffani J Johnson, Peter S Dayan, Pediatric Emergency Care Applied Research Network (Pecarn)

Faculty, Staff and Students Publications

INTRODUCTION: Headache is a common chief complaint of children presenting to emergency departments (EDs). Approximately 0.5%-1% will have emergent intracranial abnormalities (EIAs) such as brain tumours or strokes. However, more than one-third undergo emergent neuroimaging in the ED, resulting in a large number of children unnecessarily exposed to radiation. The overuse of neuroimaging in children with headaches in the ED is driven by clinician concern for life-threatening EIAs and lack of clarity regarding which clinical characteristics accurately identify children with EIAs. The study objective is to derive and internally validate a stratification model that accurately identifies the risk of EIA …

Stratification Of Risk For Emergent Intracranial Abnormalities In Children With Headaches: A Pediatric Emergency Care Applied Research Network (Pecarn) Study Protocol, Daniel S Tsze, Kimberly S Quayle, Et Al.

2020-Current year OA Pubs

INTRODUCTION: Headache is a common chief complaint of children presenting to emergency departments (EDs). Approximately 0.5%-1% will have emergent intracranial abnormalities (EIAs) such as brain tumours or strokes. However, more than one-third undergo emergent neuroimaging in the ED, resulting in a large number of children unnecessarily exposed to radiation. The overuse of neuroimaging in children with headaches in the ED is driven by clinician concern for life-threatening EIAs and lack of clarity regarding which clinical characteristics accurately identify children with EIAs. The study objective is to derive and internally validate a stratification model that accurately identifies the risk of EIA …

Heterogeneous Cardiac Sympathetic Innervation Gradients Promote Arrhythmogenesis In Murine Dilated Cardiomyopathy, Al-Hassan J Dajani, Carla Valenzuela-Ripoll, Ali Javaheri, Et Al.

2020-Current year OA Pubs

Ventricular arrhythmias (VAs) in heart failure are enhanced by sympathoexcitation. However, radiotracer studies of catecholamine uptake in failing human hearts demonstrate a proclivity for VAs in patients with reduced cardiac sympathetic innervation. We hypothesized that this counterintuitive finding is explained by heterogeneous loss of sympathetic nerves in the failing heart. In a murine model of dilated cardiomyopathy (DCM), delayed PET imaging of sympathetic nerve density using the catecholamine analog [11C]meta-Hydroxyephedrine demonstrated global hypoinnervation in ventricular myocardium. Although reduced, sympathetic innervation in 2 distinct DCM models invariably exhibited transmural (epicardial to endocardial) gradients, with the endocardium being devoid of sympathetic nerve …

Studies On Fucoidan And Its Production From Vietnamese Brown Seaweeds, Ajstd Editorialboard

ASEAN Journal on Science and Technology for Development

No abstract provided.

Marine Natural Products And Their Potential Application In The Future, Ajstd Editorialboard

ASEAN Journal on Science and Technology for Development

No abstract provided.

Investigation Of Electron Transfer In The Ksha-Kshb-R286a Protein Complex From Mycobacterium Tuberculosis, Elyse Tavares

Honors Program Theses and Projects

With drug-resistant bacteria such as Mycobacterium tuberculosis being a serious public health problem, infected individuals have minimal treatment options. By investigating the electron transfer within 3-ketosteroid-9��-hydroxylase (KshAB), a protein involved in the energy production pathway of this bacteria, it will allow for potential inhibitors of this enzyme to be designed as antibiotics against tuberculosis. The purpose of this project is to stop the interaction between the KshA and KshB complexes to prevent the bacteria from gaining energy by breaking down steroids like cholesterol. To achieve this goal, an arginine at the 286th position of the KshB protein was mutated to …