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Ic090: Ken Mattox Interview, Transcript, Friends Of The Texas Medical Center Library

2023 Oral History Project

See more at Friends of the Texas Medical Center Library Records and its finding aid.

Residents’ Perception And Support Before And After A Mega-Religious Event During Covid-19 In India, Devkant Kala, Dhani Shanker Chaubey

International Journal of Religious Tourism and Pilgrimage

This study investigated residents’ perceptions, perceived risk, trust in government, and support for a mega-religious event during the COVID pandemic. The study was conducted in the setting of the Kumbh Mela, India’s largest peaceful gathering of Hindu pilgrims. The respondents in the survey rated thirty-two statements related to positive impact, negative impact, perceived risk, trust in government, and support for the mega-religious event. Levene’s test for equality of variances and an independent samples t-test were used to investigate differences in residents’ perception and support before and after the mega-religious event. The pre-event and post-event results indicate that respondents underestimated the …

Neuronal Sirt3 Deletion Predisposes To Female-Specific Alterations In Cellular Metabolism, Memory, And Network Excitability, Jennifer N Pearson-Smith, Ruth Fulton, Christopher Q Huynh, Anna G Figueroa, Gia B Huynh, Li-Ping Liang, Lindsey B Gano, Cole R Michel, Nichole Reisdorph, Richard Reisdorph, Kristofer S Fritz, Eric Verdin, Manisha Patel

Faculty, Staff and Students Publications

Mitochondrial dysfunction is an early event in the pathogenesis of neurologic disorders and aging. Sirtuin 3 (SIRT3) regulates mitochondrial function in response to the cellular environment through the reversible deacetylation of proteins involved in metabolism and reactive oxygen species detoxification. As the primary mitochondrial deacetylase, germline, or peripheral tissue-specific deletion of SIRT3 produces mitochondrial hyperacetylation and the accelerated development of age-related diseases. Given the unique metabolic demands of neurons, the role of SIRT3 in the brain is only beginning to emerge. Using mass spectrometry-based acetylomics, high-resolution respirometry, video-EEG, and cognition testing, we report targeted deletion of SIRT3 from select neurons …

Microbiology Clinical Culture Diagnostic Yields And Antimicrobial Resistance Proportions Before And During The Covid-19 Pandemic In An Indian Community Hospital And Two Us Community Hospitals, Sumanth Gandra, Gerardo Alvarez-Uria, Dustin Stwalley, Katelin B Nickel, Kimberly A Reske, Jennie H Kwon, Erik R Dubberke, Margaret A Olsen, Jason P Burnham

2020-Current year OA Pubs

Studies comparing the impact of the COVID-19 pandemic on diagnostic microbiology culture yields and antimicrobial resistance proportions in low-to-middle-income and high-income countries are lacking. A retrospective study using blood, respiratory, and urine microbiology data from a community hospital in India and two community hospitals (Hospitals A and B) in St. Louis, MO, USA was performed. We compared the proportion of cultures positive for selected multi-drug-resistant organisms (MDROs) listed on the WHO's priority pathogen list both before the COVID-19 pandemic (January 2017-December 2019) and early in the COVID-19 pandemic (April 2020-October 2020). The proportion of blood cultures contaminated with coagulase-negative

Characterization Of Tick And Host-Associated Factors Linked To Induction Of Alpha-Gal Syndrome., Surendra Raj Sharma, Surendra Raj Sharma

Dissertations

Alpha-Gal Syndrome (AGS) is a delayed allergic reaction caused by specific IgE antibodies to the oligosaccharide galactose-α-1,3-galactose (α-gal) present in red meat. AGS is a growing concern globally, with over 34,000 confirmed cases in the United States alone. Studies have linked AGS to tick bites, which sensitizes hosts against α-gal antigens and elevates α-gal specific IgE. This dissertation investigates the role of tick and host-associated factors in AGS development. Microbiome analysis of Am. americanum ticks revealed a comprehensive core microbiome profile and showed that new Fransiella-like endosymbionts dominate and outcompete conventional tick Coxiella endosymbionts. Ticks subjected to tetracycline treatment showed …

In Silico Binding Of 2-Aminocyclobutanones To Sars-Cov-2 Nsp13 Helicase And Demonstration Of Antiviral Activity, Thahani S. Habeeb Mohammad, Yash Gupta, Cory T. Reidl, Vlad Nicolaescu, Haley Gula, Ravi Durvasula, Prakasha Kempaiah, Daniel P. Becker Ph.D.

Chemistry: Faculty Publications and Other Works

The landscape of viral strains and lineages of SARS-CoV-2 keeps changing and is currently dominated by Delta and Omicron variants. Members of the latest Omicron variants, including BA.1, are showing a high level of immune evasion, and Omicron has become a prominent variant circulating globally. In our search for versatile medicinal chemistry scaffolds, we prepared a library of substituted α-aminocyclobutanones from an α-aminocyclobutanone synthon (11). We performed an in silico screen of this actual chemical library as well as other virtual 2-aminocyclobutanone analogs against seven SARS-CoV-2 nonstructural proteins to identify potential drug leads against SARS-CoV-2, and more broadly against coronavirus …

Hiv Screening Among Immigrants Establishing Care In Maine, 2017-2021, Elizabeth Mazzeo, Elizabeth Danielson, Benjamin Felix, Kimberly Toomire, Elizabeth Eisenhardt, Evelyn Roach, Katlyn Breton, Karen Thompson, Stephen Digiovanni, Kathleen M. Fairfield

Journal of Maine Medical Center

No abstract provided.

A Genetic Locus Complements Resistance To Bordetella Pertussis-Induced Histamine Sensitization., Abbas Raza, Sean A Diehl, Dimitry N Krementsov, Laure K Case, Dawei Li, Jason Kost, Robyn L Ball, Elissa J Chesler, Vivek M. Philip, Rui Huang, Yan Chen, Runlin Ma, Anna L Tyler, J Matthew Mahoney, Elizabeth P Blankenhorn, Cory Teuscher

Faculty Research 2023

Histamine plays pivotal role in normal physiology and dysregulated production of histamine or signaling through histamine receptors (HRH) can promote pathology. Previously, we showed that Bordetella pertussis or pertussis toxin can induce histamine sensitization in laboratory inbred mice and is genetically controlled by Hrh1/HRH1. HRH1 allotypes differ at three amino acid residues with P

Healthcare Associated Infections, Nurse Staffing, And Financial Performance, Soumya Upadhyay, Dean G. Smith

Healthcare Administration and Policy Faculty Research

Healthcare associated infections (HAIs) are a concern to patients, hospital administrators and policymakers. For over than a decade, efforts have been made to hold hospitals accountable for the costs of HAIs. This study uses contingency theory as a framework to examine the association between HAIs and hospital financial performance. We use publicly available data on 2059 hospitals in 2014 to 2016 that include HAIs, staffing financial performance, and hospital and hospital market characteristics. The key independent variables are available infection rates and nurse staffing. The dependent variables are indicators of financial performance: operating margin, total margin, and days cash on …

Understanding The Burden Of Traumatic Injuries At The United States-Mexico Border: A Scoping Review Of The Literature, Benjamin A. Keller, Jeffrey Skubic, Monica Michelle Betancourt-Garcia, Romeo C. Ignacio, Jason S. Radowsky, Alan H. Tyroch, Carlos Palacio Lascano, Bellal Joseph, Collin Stewart, Aaron Silva

School of Medicine Publications

The United States-Mexico border is the busiest land crossing in the world and faces continuously increasing numbers of undocumented border crossers. Significant barriers to crossing are present in many regions of the border, including walls, bridges, rivers, canals, and the desert, each with unique features that can cause traumatic injury. The number of patients injured attempting to cross the border is also increasing, but significant knowledge gaps regarding these injuries and their impacts remain. The purpose of this scoping literature review is to describe the current state of trauma related to the US–Mexico border to draw attention to the problem, …

International Consensus Statement On Allergy And Rhinology: Allergic Rhinitis – 2023, Sarah K. Wise, Cecelia C. Damask, Lauren T. Roland, Charles Ebert, Joshua M. Levy, Sandra Lin, Amber Luong, Kenneth Rodriguez, Ahmad R. Sedaghat, Helene J. Krouse

School of Medicine Publications

Background

In the 5 years that have passed since the publication of the 2018 International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR-Allergic Rhinitis 2018), the literature has expanded substantially. The ICAR-Allergic Rhinitis 2023 update presents 144 individual topics on allergic rhinitis (AR), expanded by over 40 topics from the 2018 document. Originally presented topics from 2018 have also been reviewed and updated. The executive summary highlights key evidence-based findings and recommendation from the full document.

Methods

ICAR-Allergic Rhinitis 2023 employed established evidence-based review with recommendation (EBRR) methodology to individually evaluate each topic. Stepwise iterative peer review and consensus …

Hypervirulent R20291 Clostridioides Difficile Spores Show Disinfection Resilience To Sodium Hypochlorite Despite Structural Changes, Dmitry Malyshev, Imogen Anne Jones, Matthew Mckracken, Rasmus Öberg, Glenn M. Harper, Lovleen Tina Joshi, Magnus Andersson

Peninsula Dental School

No abstract provided.

Force Majeure & Covid-19: A Clause Changed?, Claudia Petcu

DePaul Business & Commercial Law Journal

No abstract provided.

Sr 22-23-31 Cc, Marshall University Faculty Senate

Recommendations

No abstract provided.

Surgical Site Infection Caused By Non-Hemolytic Staphylococcus Aureus Following A Total Knee Arthroplasty At A Class C Hospital In Indonesia, Satiyo, Elsye Maria Rosa

Folia Medica Indonesiana

Highlights: • A patient with grade IV osteoarthritis underwent an arthroplasty and developed a surgical site infection caused by Staphylococcus aureus. • The treatment for the surgical site infection included antibiotic medications and revision surgery for the previous total knee arthroplasty. Abstract: This article presents a case report of a knee arthroplasty surgical site infection caused by non-hemolytic Staphylococcus aureus. A 56-year-old woman came to the Orthopedic Outpatient Clinic, with the chief complaint of pain in the left knee for the last three years. After being diagnosed with grade IV osteoarthritis, the patient underwent a total knee arthroplasty. The patient …

The Histopathological Features Of Syphilis And Its Mimickers, Indah Purnamasari, Afif Nurul Hidayati, Etty Hary Kusumastuti, Isaak Effendy

Folia Medica Indonesiana

Highlights: • The importance of having a strong suspicion for syphilis and maintaining close contact between dermatologists and pathologists cannot be understated. • Understanding the clinical relationship and histopathological features of syphilis is crucial for accurate diagnosis and distinction from its histopathologic mimickers. Abstract: Settings Syphilis, also known as "the great imitator," is a sexually transmitted infection with a variety of clinical symptoms and histopathological similarities to other infectious diseases. Public health concerns about syphilis have grown significantly. Since 2000, there has been an increase in syphilis prevalence in the United States, with a 17.6% increase from 2015 to 2016. …

Proportions Of Group B Streptococcus Isolation From Pregnant Women's Vaginal And Rectal Swab Specimens At A Tertiary Hospital In Surabaya, Indonesia, Ivanna, Eddy Bagus Wasito, Kartuti Debora

Folia Medica Indonesiana

Highlights: • Rectal and vaginal swab specimens were collected from pregnant women, and there was no significant difference in the proportions of group B Streptococcus isolation. • Combined vaginal and rectal swab cultures provide a higher isolation of group B Streptococcus. Abstract : Group B Streptococcus is a Gram-positive bacterium found in women. It causes high-risk mortality in pregnant women, newborns, and the elderly. This study aimed to compare group B Streptococcus (GBS/Streptococcus agalactiae) proportions from different collection sites (vaginal and rectal swabs). This was an analytic observational study with a hospital-based cross-sectional design. A total of 74 swabs were …

Session Ia: Psychology Presentation 3 - The Effects Of Covid-19 Pandemic Isolation On Multiple Aspects Of Child And Adolescent Lives, Alissa Carpenter

Life of the Scholar Multidisciplinary Conference

This presentation seeks to be a thorough literature review seeking to answer the question of “what effects did the COVID-19 pandemic have on children and adolescents?” Various topics (effects) will be discussed. The underlying hypothesis of this work is that the COVID-19 pandemic did more than just infect people with a virus. I intend to shed light on the complexity of effects that the global shutdown had on the well-being and performance of children and adolescents.

Sustainable Management Of Facemask Waste Generated From Covid-19 Pandemic In Bhutan, Tshering Yangdon, Twisuk Punpeng, Sirima Mongkolosomit, Kampol Nanthapong, Kinzang Yangden

Journal of Health Research

Background: The rise in facemask waste with the uncertainty of deposition data and all its concomitant pressure on management has resulted in new risks and challenges for achieving sustainable development goals (SDGs). The purpose of this mixed methods study was to estimate facemask waste generation and examine management in Bhutan since the COVID-19 pandemic.

Method: One thousand five hundred and twenty-seventh (1,527) consenting members of the public from Class A Thromdes (self-governing municipalities) were surveyed online from February to April 2022, to estimate mask waste using descriptive statistics. This was supported by the waste characterization conducted in Memelhakha, the biggest …

Extreme Weather And Melioidosis: An Endemic Tropical Disease In Penampang District Of Sabah, Malaysia, Sam Froze Jiee, Kai Joo Lim, Daryl Sin Choon Vui, Dina Peter Marius, Nurul Syafiqah Illyana, Anisah Jantim

Journal of Health Research

Background: Melioidosis is a fatal, but preventable communicable disease that is endemic in several parts of the world, including the state of Sabah, Malaysia, which is located in the northern part of Borneo Island. Flooding is one of the most regular natural disasters affecting some parts of Malaysia, including Sabah. The main aim of this study was to determine if rainfall and floods were significant risk factors contributing to the substantial burden of melioidosis in the Penampang district from 2015 to 2020.

Method: We analyzed 64 culture-confirmed cases of melioidosis in the Penampang district, Sabah, between 2015 and 2020 to …

Clinically Adjudicated Reference Standards For Evaluation Of Infectious Diseases Diagnostics, Robin Patel, Ephraim L Tsalik, Scott Evans, Vance G Fowler, Sarah B Doernberg, Antibacterial Resistance Leadership Group

Faculty, Staff and Student Publications

Lack of a gold standard can present a challenge for evaluation of diagnostic test accuracy of some infectious diseases tests, particularly when the test's accuracy potentially exceeds that of its predecessors. This approach may measure agreement with an imperfect reference, rather than correctness, because the right answer is unknown. Solutions consist of multitest comparators, including those that involve a test under evaluation if multiple new tests are being evaluated together, using latent class modeling, and clinically adjudicated reference standards. Clinically adjudicated reference standards may be considered as comparator methods when no predefined test or composite of tests is sufficiently accurate; …

Developing A Consensus To Support Health And Social Care Professionals And Patients Manage Nutrition In The Context Of Covid‐19 Recovery, Hernandez Ya Tronco, Anna Julian, Elizabeth C. Weekes, Jane Murphy, Gary Frost, Mary Hickson

School of Health Professions

BackgroundThe long-term effects on people who have had COVID-19 affect nutrition and can be influenced by diet conversely. Specific nutritional guidelines, however, were scarce at the beginning of 2020, and empirical literature was also lacking. Conventional research methodologies needed to be adapted to review the available literature that could be relevant to the United Kingdom and policy documents as well as collect the views of health and care staff. The aim of this paper is to describe the method to develop consensus statements from experts to address the necessary nutritional support and what emerged from this.MethodsA nominal group technique (NGT) …

Behavioural Defences Against Parasites Across Host Social Structures, Sebastian Stockmeier, Yuko Ulrich, Gregory F. Albery, Sylvia Cremer, Patricia C. Lopes

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

1. Animals exhibit a variety of behavioural defences against socially transmitted parasites. These defences evolved to increase host fitness by avoiding, resisting or tolerating infection.
2. Because they can occur in both infected individuals and their uninfected social partners, these defences often have important consequences for the social group.
3. Here, we discuss the evolution and ecology of anti-parasite behavioural defences across a taxonomically wide social spectrum, considering colonial groups, stable groups, transitional groups and solitary animals.
4. We discuss avoidance, resistance and tolerance behaviours across these social group structures, identifying how social complexity, group composition and interdependent social relationships may contribute to the …

Predicting The Impact Of Climate Change On The Distribution Of Rhipicephalus Sanguineus In The Americas, Marcos Sánchez Pérez, Teresa Patricia Feria-Arroyo, Crystian Sadiel Venegas Barrera, Carolina Sosa-Gutiérrez, Javier Torres, Katherine A. Brown, Guadalupe Gordillo Pérez

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Climate change may influence the incidence of infectious diseases including those transmitted by ticks. Rhipicephalus sanguineus complex has a worldwide distribution and transmits Rickettsial infections that could cause high mortality rates if untreated. We assessed the potential effects of climate change on the distribution of R. sanguineus in the Americas in 2050 and 2070 using the general circulation model CanESM5 and two shared socioeconomic pathways (SSPs), SSP2-4.5 (moderate emissions) and SSP2-8.5 (high emissions). A total of 355 occurrence points of R. sanguineus and eight uncorrelated bioclimatic variables were entered into a maximum entropy algorithm (MaxEnt) to produce 50 replicates per …

Factors Influencing The Use Of Multiple Hiv Prevention Services Among Transport Workers In A City In Southwestern Uganda, Benjamin Betunga, Phionah Atuhaire, Catherine Nakasiita, Christa Kanyamuneza, Proscovia Namiiro, Joseph Tugume, Matovu Hairat, Ahmed Sarki, Benedicto Mugabi, Birungi Lilian, Richard Mugisha Richard Mugisha, Edward Kumakech, John Baptist Asiimwe

School of Nursing & Midwifery, East Africa

The use of multiple HIV prevention services has been found to decrease the risk of acquiring HIV when tailored to individuals at risk of HIV exposure, including transport workers. Therefore, we assessed the uptake of multiple HIV prevention services (≥2) and associated factors among transport workers in a city in Southwestern Uganda. This cross-sectional study comprised motorcycle taxi riders, motor vehicle and truck drivers, aged 18 to 55 years who were selected and responded to an interviewer-administered questionnaire, between November 2021 and February 2022. Data was analyzed using descriptive statistical and modified Poisson regression analyses. Out of 420 participants, 97.6% …

Association Of Qaca/B And Smr Carriage With Staphylococcus Aureus Survival Following Exposure To Antiseptics In An Ex Vivo Venous Catheter Disinfection Model, J Chase Mcneil, Lauren M Sommer, Jesus G Vallejo, Kristina G Hulten, Sheldon L Kaplan

Faculty, Staff and Students Publications

Many health care centers have reported an association between Staphylococcus aureus isolates bearing efflux pump genes and an elevated MIC/minimal bactericidal concentration (MBC) to chlorhexidine gluconate (CHG) and other antiseptics. The significance of these organisms is uncertain, given that their MIC/MBC is typically far lower than the CHG concentration in most commercial preparations. We sought to evaluate the relationship between carriage of the efflux pump genes qacA/B and smr in S. aureus and the efficacy of CHG-based antisepsis in a venous catheter disinfection model. S. aureus isolates with and without smr and/or qacA/B were utilized. The CHG MICs were determined. …

Immigration Related Trauma Among Haitians: Barriers To Treatment And The Role Of Faith In Creating Resiliency, Sandra Garcon Degerville

Doctoral Dissertations and Projects

The topic of this writer’s dissertation is immigration-related trauma among Haitians, barriers to treatment, and the role of faith in creating resiliency. The purpose of this qualitative push and pull hermeneutic phenomenological study is to understand the lived experiences of people who have immigrated to the United States (US). To better understand these lived experiences, it is imperative to also examine the experiences of Haitian immigrants from the gateway countries of Brazil, Chile, Canada, and the Dominican Republic. It is known that a number of Haitians have entered the US directly (legally or illegally) and a great many entered by …

Georgia Academy Of Science 2023 Annual Meeting Program, Al Mead, Dominic Desantis, Hasitha Mahabaduge, Samuel Mutiti, Kristine White, Cason Kelley

Georgia Journal of Science

This is the program of the 2023 Annual Meeting of the Georgia Academy of Science.

Changes In Physical Activity During The Covid-19 Pandemic: A Mixed Methods Assessment, Andrew Corbett, Kathryn E. Wilson, Andrew Van Horn, Jessica D. Ayers, Hector Hurmuz, Athena Aktipis

International Journal of Exercise Science

International Journal of Exercise Science 16(5): 327-341, 2023. COVID-19 was declared a global pandemic in March 2020. Resulting containment protocols altered the day-to-day lives of people around the globe, impacting typical physical activity patterns. The purpose of this mixed-method study was to understand how physical activity changes occurred during the first few months of the COVID-19 pandemic. Participants (n = 271) completed a survey including a qualitative item asking for descriptions of how their physical activity had changed, as well as a categorical item asking whether they had become more active, stayed equally as active, or become less active …

Overcoming The Impostor Phenomenon: Exploring The Strategies Special Education Charter School Leaders Used To Cope During The Covid-19 Pandemic, Damaris Ocasio Owens

Dissertations

Purpose: The purpose of this descriptive mixed method study was to explore and describe the coping skills used to overcome the nine behavioral characteristics by special education charter school leaders who identified as experiencing impostor phenomenon (IP) by the Clance Impostor Phenomenon Scale (Clance,1985), while leading the transition to distance learning in response to the COVID-19 pandemic. Methodology: This descriptive mixed-methods research design used quantitative and qualitative data to identify special education leaders with IP and explore the coping skills they used during distance learning. The first phase of the study was a quantitative 20-question survey, the CIPS, used to …