Digital Commons Network^™

Vaccine Effectiveness Against Influenza A(H3n2)-Associated Hospitalized Illness: United States, 2022, Mark W Tenforde, Jennie H Kwon, Et Al.

2020-Current year OA Pubs

BACKGROUND: The COVID-19 pandemic was associated with historically low influenza circulation during the 2020-2021 season, followed by an increase in influenza circulation during the 2021-2022 US season. The 2a.2 subgroup of the influenza A(H3N2) 3C.2a1b subclade that predominated was antigenically different from the vaccine strain.

METHODS: To understand the effectiveness of the 2021-2022 vaccine against hospitalized influenza illness, a multistate sentinel surveillance network enrolled adults aged ≥18 years hospitalized with acute respiratory illness and tested for influenza by a molecular assay. Using the test-negative design, vaccine effectiveness (VE) was measured by comparing the odds of current-season influenza vaccination in influenza-positive …

The Abrupt Educational Switch: Impact Of Covid-19 And Lessons Learned For Health Science Faculty And Students, Kathleen Klein, Marylou Galantino, Tara Crowell, Renne Cavazza

Internet Journal of Allied Health Sciences and Practice

Purpose: The abrupt educational transition from in-class to virtual instruction during spring of 2020 found many faculty and students in uncharted territory. The purpose of this study was to survey both faculty and students in the School of Health Sciences to better understand the switch from face-to-face instruction to remote learning. Methods: Both qualitative and quantitative data was collected regarding this experience. The first task was to identify faculty’s responses and actions taken, perception of alternative teaching experience and impact on student learning, determine needs to prepare and address new course design and delivery, and explore perception of changes to …

Accelerating Biosafety Capacity Building To Ensure National Biosecurity, Peipei Liu, Jiafu Jiang, Hao Lu, Peilei Cong, Lilin Zhao, Gexia Qiao, Dongsheng Zhou, Guizhen Wu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Biosafety is an essential part of the national security system, which is related to people's lives and health, the country's longterm stability, and sustainable development, which is the bottom line that must be guaranteed. The international biosafety situation is grim and complex, while domestic biosafety faces challenges. Therefore, biosafety capacity building has become an international hot spot, among which scientific and technological innovation, talent training, and infrastructure platform construction are the top priorities. Although China has achieved strategic results in the rapid identification of pathogens, research, and development of specific vaccines and medicine in fighting against COVID-19 by relying on …

Ecological Impacts Of Climate Change And Adaption Strategies, Xinru Wan, Chaoyuan Cheng, Defeng Bai, Zhibin Zhang

Bulletin of Chinese Academy of Sciences (Chinese Version)

In 2022, The United Nations' Intergovernmental Panel on Climate Change (IPCC) released the Sixth Assessment Report (AR6) of Climate Change 2022:Impact, Adaptation and Vulnerability and China Meteorological Administration issued China Climate Chang Blue Book (2022). This paper presents a brief summary of the assessment report on the ecological impacts of climate change and adaption strategies, and related studies of China by reviewing additional literature. The AR6 report and related studies indicate that the ecological impacts of climate warming are significant, including advancement of phenology, extension of plant growing season; species range shift towards high latitude or elevation, tree line moving …

Adiponectin-Mediated Promotion Of Cd44 Suppresses Diabetic Vascular Inflammatory Effects, Yanru Duan, Shihan Zhang, Yuanyuan Xing, Ye Wu, Wen Zhao, Pinxue Xie, Huina Zhang, Xinxiao Gao, Yanwen Qin, Yajing Wang, Xin-Liang Ma, Yunhui Du, Huirong Liu

Department of Emergency Medicine Faculty Papers

While adiponectin (APN) was known to significantly abolish the diabetic endothelial inflammatory response, the specific mechanisms have yet to be elucidated. Aortic vascular tissues from mice fed normal and high-fat diets (HFD) were analyzed by transcriptome analysis. GO functional annotation showed that APN inhibited vascular endothelial inflammation in an APPL1-dependent manner. We confirmed that activation of the Wnt/β-catenin signaling plays a key role in APN-mediated anti-inflammation. Mechanistically, APN promoted APPL1/reptin complex formation and β-catenin nuclear translocation. Simultaneously, we identified APN promoted the expression of CD44 by activating TCF/LEF in an APPL1-mediated manner. Clinically, the serum levels of APN and CD44 …

The Relationship Among Perfectionism, Perceived Stress, And Coping In Baccalaureate Nursing Students, Amanda Finley

Dissertations

Perfectionism in nursing students is an understudied problem that may affect student and workforce success. Perfectionism has been linked to increased stress and less effective coping styles, as well as depression, anxiety and other psychological alterations. However, it has rarely been studied in nursing students. Studying perfectionism in this population is important because it may increase the likelihood that new nurses will struggle with the stress of practice and it could be a significant factor in early career attrition. The purpose of this descriptive, correlational study was to gain a better understanding of the incidence of perfectionism in a nursing …

An Interesting Case Of Disseminated Histoplasmosis In A Patient With Hemophagocytic Lymphohistiocytosis, Rachel Ann Pellegrino, Roopa Naik, Atul Bali

Student Publications

Histoplasmosis is a common mycosis in North and Central America caused by Histoplasma capsulatum. Affected patients typically remain asymptomatic. However, in some individuals, histoplasmosis can present as a severe illness, usually occurring in patients with underlying risk factors such as the immunocompromised (e.g., acquired immunodeficiency syndrome (AIDS), treatment with immunosuppressive agents), and the elderly without underlying immunocompromised conditions. Here, we present a case of disseminated histoplasmosis diagnosed as an incidental finding on bone marrow biopsy while treating a hospitalized patient for hemophagocytic lymphohistiocytosis. The patient presented with weight loss, anorexia, fatigue, and generalized weakness. The patient was successfully treated with …

Usage Of Electronic Information Resources (Eirs) For Improved Nursing Research And Health-Care Delivery In Nigeria, Bolaji David Oladokun, Abdulfatai Enehe Seidu, Humphrey I. Wiche Phd, Dauda Yahaya, Joseph Atule

Library Philosophy and Practice (e-journal)

This study examined the usage of electronic information resources (EIRs) for improved nursing research and health-care delivery in Nigeria. A descriptive survey method was used for the study. The population consisted of 120 nursing and midwifery students and 5 healthcare providers at Grimmard School of Nursing and Midwifery, Anyigba, Kogi State of Nigeria totalling 125. Five (5) research questions guided the conduct of this study. Analysis and discussion of the study were based on major findings of the study. The results revealed that, nursing and midwifery students sourced e-resources through online databases, smart phones, institutional repositories and search engines. The …

Acceptance And Attitude Toward Vaccination Against Covid-19: A Cross-Sectional Study Of Academic Librarians In Nigeria., Murtala Aliyu, Abbas Adamu Lamido Gora

Library Philosophy and Practice (e-journal)

This study investigated the level of acceptance and attitude toward vaccination against COVID-19 among academic librarians in Nigeria. It is guided by two objectives, two research questions and two null-hypothesis. The population of the study consisted of 7,287 certified librarians spread across Nigerian. Krejcie and Morgan’s table for determining sample size for research activities was used, and a response rate of 231 was achieved out of the sample size of 364. A non-probability sampling involving purposive sampling techniques was used. Self-developed questionnaire was designed using Google Form mobile application with 4-Points-Likert scale, which was administered to respondents on several LIS …

Sources Of Stress, Burnout, And Career Decisions Of Male Health And Nursing Professionals: A Qualitative Inquiry Of The Challenges During The Covid-19 Pandemic, Luis Miguel Dos Santos

The Qualitative Report

The human resources and workforce shortage of registered health and nursing professionals has been a long-term problem in health systems internationally, particularly during the COVID-19 pandemic. Many health and nursing professionals face stress and burnout, which may influence their career decisions and long-term human resources development. The purpose of this study is to investigate and understand the relationship(s) between sources of stress and the reasons why male health and nursing professionals decide to leave the profession within the next six months. With the employment of the social cognitive career and motivation theory and general inductive approach with 40 male health …

Evaluation Of Peroxyacetic Acid, Liquid Buffered Vinegar, And Cultured Dextrose Fermentate As Potential Antimicrobial Interventions For Raw Chicken Livers, Leslie Pearl M. Cancio, Mary-Grace C. Danao, Gary Sullivan, Byron D. Chaves

Department of Nutrition and Health Sciences: Faculty Publications

This study aimed to evaluate the use of peroxyacetic acid (PAA), buffered vinegar (BV), and cultured dextrose fermentate (CDF) to reduce Salmonella on artificially inoculated raw chicken livers, one of the most consumed offal around the world. Samples were inoculated with a 5-strain cocktail of poultry-borne Salmonella to obtain 10⁶ CFU/g and immersed for 90 s with agitation in one of the following treatments: distilled water (control), 450 ppm PAA, 2.0% (w/v) BV, or 1.5% (w/v) CDF, prior to storing at 4^oC. Salmonella was enumerated on XLD agar and monitored for 14 days. Data were analyzed using …

Virulence Factors Of Helicobacter Pylori, Haifaa B. Najee, Shaimaa M.S. Zainulabdeen

Muthanna Medical Journal

One of the most common cancers in both genders, gastric cancer is currently the fourth leading cause of cancer-related deaths globally. The interplay of hereditary and environmental variables, including Helicobacter pylori (H. pylori) infection, is linked to the etiology of stomach cancer. Due to a number of evasive mechanisms brought on by the virulence factors that the bacteria expresses, the invasion, survival, colonization, and stimulation of further inflammation within the gastric mucosa are all conceivable. To improve eradication efforts and stop the potential induction of carcinogenesis, it is essential to understand the pathogenicity mechanisms of H. pylori. This review focuses …

Elderly And Smartphone Apps: Case Study With Lightweight Mysejahtera, Ciu Yung Seek, Shih Yin Ooi, Ying Han Pang, Sook Ling Lew, Xin Yun Heng

Journal of Informatics and Web Engineering

The outbreak of Covid-19 in the past 2 years has made the usage of contact-tracing app almost mandatory in Malaysia. Though the usage is seeming to be simple, but one interesting phenomenon can be observed in Malaysia is that most of the senior citizen are found not using smartphones regularly. While check-in through MySejahtera (the primary contract-tracing app used in Malaysia) for business, premises, and transports has made compulsory, it does bring a lot of inconveniences to the elderly. Many elderlies start to learn how to use smartphone and government has also taking initiative by providing free or low-cost smartphone …

Associations Of Physical Inactivity And Covid-19 Outcomes Among Subgroups, Gary N. Smith, Deborah Rohm Young, James F. Sallis, Aileen Baecker, Deborah A. Cohen, Robert E. Sallis, Claudia L. Nau

Pomona Faculty Publications and Research

Selected as the AJPM paper of the year. This paper reports additional evidence that regular physical exercise prior to COVID infection substantially reduces the chances of hospitalization, admission to intensive care units, and death.

Influence Of Canonical And Non-Canonical Ifnlr1 Isoform Expression On Interferon Lambda Signaling, John Evans

MUSC Theses and Dissertations

Interferon lambdas (IFNLs) are innate immune cytokines that induce antiviral cellular responses by signaling through a heterodimer composed of IL10RB and the interferon lambda receptor 1 (IFNLR1). Multiple IFNLR1 transcriptional variants are expressed in vivo and are predicted to encode distinct protein isoforms whose function is not fully established. IFNLR1 isoform 1 has the highest relative transcriptional expression and encodes the full-length functional form that supports canonical IFNL signaling. IFNLR1 isoforms 2 and 3 have lower relative expression and are predicted to encode signaling defective proteins. To gain insight into IFNLR1 function and regulation, we explored how altering relative expression …

Atlas Of Ticks (Acari: Argasidae, Ixodidae) In Germany: 1st Data Update, Franz Rubel, Stefan Zaenker, Alexander Weigand, Dieter Weber, Lidia Chitimia-Dobler, Olaf Kahl

Harold W. Manter Laboratory of Parasitology: Library Materials

The first data update of the atlas of ticks in Germany published in 2021 is presented here. This atlas provides maps based on georeferenced tick locations of 21 species endemic in Germany as well as three tick species that are regularly imported to Germany. The data update includes the following numbers of newly georeferenced tick locations: 17 Argas reflexus, 79 Carios vespertilionis, 2 Dermacentor marginatus, 43 Dermacentor reticulatus, 4 Haemaphysalis concinna, 3 Haemaphysalis punctata, 3 Hyalomma rufipes, 3 Ixodes apronophorus, 9 Ixodes arboricola, 1 Ixodes ariadnae, 30 Ixodes canisuga, …

A Mast Cell-Thermoregulatory Neuron Circuit Axis Regulates Hypothermia In Anaphylaxis, Chunjing Bao, Ouyang Chen, Huaxin Sheng, Jeffrey Zhang, Yikai Luo, Byron W Hayes, Han Liang, Wolfgang Liedtke, Ru-Rong Ji, Soman N Abraham

Faculty, Staff and Student Publications

IgE-mediated anaphylaxis is an acute life-threatening systemic reaction to allergens, including certain foods and venoms. Anaphylaxis is triggered when blood-borne allergens activate IgE-bound perivascular mast cells (MCs) throughout the body, causing an extensive systemic release of MC mediators. Through precipitating vasodilatation and vascular leakage, these mediators are believed to trigger a sharp drop in blood pressure in humans and in core body temperature in animals. We report that the IgE/MC-mediated drop in body temperature in mice associated with anaphylaxis also requires the body's thermoregulatory neural circuit. This circuit is activated when granule-borne chymase from MCs is deposited on proximal TRPV1+ …

Imaging Of Brain Structural And Functional Effects In People With Human Immunodeficiency Virus, Erin E O'Connor, Edith V Sullivan, Linda Chang, Dima A Hammoud, Tony W Wilson, Ann B Ragin, Christina S Meade, Jennifer Coughlin, Beau M Ances

2020-Current year OA Pubs

Before the introduction of antiretroviral therapy, human immunodeficiency virus (HIV) infection was often accompanied by central nervous system (CNS) opportunistic infections and HIV encephalopathy marked by profound structural and functional alterations detectable with neuroimaging. Treatment with antiretroviral therapy nearly eliminated CNS opportunistic infections, while neuropsychiatric impairment and peripheral nerve and organ damage have persisted among virally suppressed people with HIV (PWH), suggesting ongoing brain injury. Neuroimaging research must use methods sensitive for detecting subtle HIV-associated brain structural and functional abnormalities, while allowing for adjustments for potential confounders, such as age, sex, substance use, hepatitis C coinfection, cardiovascular risk, and others. …

Ferroptosis Hijacking By Mycobacterium Tuberculosis, Boyi Gan

Faculty, Staff and Student Publications

A recent study from Nature Communications reveals that Mycobacterium tuberculosis can hijack epigenetic machinery in host cells and induce host cell ferroptosis, which promotes pathogen pathogenicity and spread. These findings also suggest new therapeutic strategies to treat tuberculosis.

Application Of Convergent Science And Technology Toward Ocular Disease Treatment, Ayca Bal-Ozturk, Ece Ozcan-Bulbul, Hazal Ezgi Gultekin, Berivan Cecen, Ebru Demir, Atefeh Zarepout, Sibel Cetinel, Ali Zarrabi

Henry M. Rowan College of Engineering Departmental Research

Eyes are one of the main critical organs of the body that provide our brain with the most information about the surrounding environment. Disturbance in the activity of this informational organ, resulting from different ocular diseases, could affect the quality of life, so finding appropriate methods for treating ocular disease has attracted lots of attention. This is especially due to the ineffectiveness of the conventional therapeutic method to deliver drugs into the interior parts of the eye, and the also presence of barriers such as tear film, blood-ocular, and blood-retina barriers. Recently, some novel techniques, such as different types of …

Monkeypox Proctitis: A Case Of Targeted Treatment With Tecovirimat., Premalkumar Patel, Cynthia Espinosa, Varsha Konyala, Nicholas S. Camps, Estafenia Cecilio, Aakangsha Jain, Claudio Tuda

HPD Articles

Monkeypox (MPX) is an exanthematous disease first identified in the 1950s, associated with animals in Central and Western Africa, and has since been found sporadically worldwide. In May 2022, a returning family from Nigeria tested positive for MPX, which marked the onset of the current outbreak. It has now become a disease of concern in most parts of the world. The current standings are nearing 90,000 cases, with numbers increasing daily. The United States reported 29,711 cases so far. The characteristic exanthem of MPX is known to be present ubiquitously on the human habitus, with recent reports describing anogenital and …

Ms 083 Guide To Harold Pruessner, Md Papers (1964-1998), Harold Pruessner (1925-2007)

Manuscript Finding Aids

The Harold Pruessner, MD papers contains documents relating to his role at the University of Texas Medical School at Houston, particularly in the Department of Family Practice. Contents include articles, curricula, training material, information about family practice, and other administrative materials. There is also an audio recording of an interview with Dr. Pruessner from 1998. Items date from 1964 to 1998, with most of them corresponding to his time in Houston, Texas. See more at MS 083.

Credit Suisse Group Takes Decisive Action To Pre-Emptively Strengthen Liquidity And Announces Public Tender Offers For Debt Securities, Credit Suisse

Documents

No abstract provided.

Spatial Pattern And Environmental And Social Factors Of Monkeypox In The Contiguous United States, Linbo Han

USF Tampa Graduate Theses and Dissertations

Monkeypox is a rare viral disease that is usually transmitted to humans through contact with infected animals, such as rodents or primates. Although its symptoms are similar to those of smallpox, monkeypox is generally less severe and rarely fatal. In recent years, however, there has been an uptick in the number of reported cases, with a large outbreak occurring in several parts of the world in May 2022. This has raised concerns among public health officials and researchers, who are working to better understand the factors that contribute to the spread of the disease. One promising approach to studying the …

How Have Researchers Defined Institutions, Politics, Organizations And Governance In Research Related To Epidemic And Pandemic Response? A Scoping Review To Map Current Concepts, Austin Wu, Shivangi Khanna, Shelly Keidar, Peter Berman, Laura Jane Brubacher

Faculty, Staff and Student Publications

In recent years, the literature on public health interventions and health outcomes in the context of epidemic and pandemic response has grown immensely. However, relatively few of these studies have situated their findings within the institutional, political, organizational and governmental (IPOG) context in which interventions and outcomes exist. This conceptual mapping scoping study synthesized the published literature on the impact of IPOG factors on epidemic and pandemic response and critically examined definitions and uses of the terms IPOG in this literature. This research involved a comprehensive search of four databases across the social, health and biomedical sciences as well as …

Partnering With Patients And Families Living With Chronic Conditions To Coproduce Diagnostic Safety Through Ourdx: A Previsit Online Engagement Tool, Sigall K Bell, Zhiyong J Dong, Catherine M Desroches, Nicholas Hart, Stephen Liu, Brianna Mahon, Long H Ngo, Eric J Thomas, Fabienne Bourgeois

Faculty, Staff and Student Publications

OBJECTIVE: Patients and families are key partners in diagnosis, but methods to routinely engage them in diagnostic safety are lacking. Policy mandating patient access to electronic health information presents new opportunities. We tested a new online tool ("OurDX") that was codesigned with patients and families, to determine the types and frequencies of potential safety issues identified by patients/families with chronic health conditions and whether their contributions were integrated into the visit note.

METHODS: Patients/families at 2 US healthcare sites were invited to contribute, through an online previsit survey: (1) visit priorities, (2) recent medical history/symptoms, and (3) potential diagnostic concerns. …

Ide-Cel Or Standard Regimens In Relapsed And Refractory Multiple Myeloma, Paula Rodriguez-Otero, Ravi Vij, Et Al.

2020-Current year OA Pubs

BACKGROUND: Survival is poor among patients with triple-class-exposed relapsed and refractory multiple myeloma. Idecabtagene vicleucel (ide-cel), a B-cell maturation antigen-directed chimeric antigen receptor (CAR) T-cell therapy, previously led to deep, durable responses in patients with heavily pretreated relapsed and refractory multiple myeloma.

METHODS: In this international, open-label, phase 3 trial involving adults with relapsed and refractory multiple myeloma who had received two to four regimens previously (including immunomodulatory agents, proteasome inhibitors, and daratumumab) and who had disease refractory to the last regimen, we randomly assigned patients in a 2:1 ratio to receive either ide-cel (dose range, 150×10

RESULTS: A total …

Long Covid & Antidepressants, Rafael Rivas-Vázquez, Enrique J. Carrazana, Mark A. Blais, Gustavo J. Rey, Emma Rivas-Vázquez, Alan Quintana

Faculty Articles

Three years into this historic pandemic, the scientific and healthcare communities continue to learn a great deal regarding COVID-19, the disease that is produced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The most urgent and immediate focus has been on vaccine development for disease prevention/mitigation and on identification of effective therapeutic interventions for acute phase of illness. However, attention is increasingly being placed on formulating treatment strategies for individuals who are post-COVID-19 and experiencing a syndrome of persistent cognitive, somatic and behavioral symptoms that is being referred to as long COVID. In addition to identifying novel compounds that …

The Pathogenesis Of Covid-19: Hypercoagulation And D-Dimer In Thrombotic Complications, Leonid Dubey, Halyna Lytvyn, Olha Dorosh, Nataliya Dubey, Olena Kozlova, Michal Pruc, Nina Kubikowska, Lukasz Szarpak, Kavita Batra, Francesco Chirico, Gabriella Nucera, Svitlana Doan, Uljana Shevtsiv

School of Medicine Faculty Research

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) caused a new coronavirus disease (COVID-19), which is highly contagious and its pathogenesis has not been fully elucidated. In COVID-19, the inflammation and blood coagulation systems are excessively activated. SARS-CoV- 2 damages endothelial cells and pneumocytes, which leads to disruption of hemostasis in SARS. Thromboembolism is the main cause of mortality in patients with COVID-19. Clots, including pulmonary embolism (PE) and deep vein thrombosis (DVT), ranging from minor to fatal complications of the SARS-CoV-2 infection are known. Individuals with pre-existing diseases are more susceptible to the development of blood clots and poor outcomes. …

Nationwide Results Of Microorganism Antigen Testing As A Component Of Preoperative Synovial Fluid Analysis., Krista O'Shaughnessey Toler, Pearl Ravindra Paranjape, Alex Mclaren, Brett Levine, Alvin Ong, Carl Deirmengian

Rothman Institute Papers

BACKGROUND: Antigen immunoassays to detect synovial fluid (SF) microorganisms have recently been made available for clinical use. The purpose of this study was to determine the sensitivity and specificity of an SF microorganism antigen immunoassay detection (MID) panel, evaluate the panel's capability to detect microorganisms in the setting of culture-negative periprosthetic joint infection (PJI), and determine diagnostic predictive values of the MID panel for PJI.

METHODS: This study included 67,441 SF samples obtained from a hip or knee arthroplasty, from 2,365 institutions across the United States, submitted to 1 laboratory for diagnostic testing. All data were prospectively compiled and then …