Digital Commons Network^™

Healthy Eating And Physical Activity: Analysing Soweto’S Young Adults’ Perspectives With An Intersectionality Lens, Gudani Mukoma, Edna Bosire, Sonja Klingberg, Shane A. Norris

Brain and Mind Institute

Background and objectives: Non-communicable diseases (NCDs) are taking a toll on Africa’s youth at younger ages than in other regions. These are attributed to risk factors that usually advance in adolescence, such as unhealthy diets and reduced physical activity. Young adults in South Africa, particularly women, tend to be sedentary, consume energy-dense diets low in micronutrients, and are more likely to develop NCDs much earlier in life than those in high-income countries. With an intersectionality perspective, this study explored young adults’ barriers and solutions to addressing these risk factors in Soweto.

Setting: Soweto, Johannesburg, South Africa, is one …

Association Between Sars-Cov-2 Variants And Frequency Of Acute Symptoms: Analysis Of A Multi-Institutional Prospective Cohort Study-December 20, 2020-June 20, 2022., Ralph C, Wang, Michael Gottlieb, Juan Carlos C. Montoy, Robert M. Rodriguez, Huihui Yu, Erica S. Spatz, Christopher W. Chandler, Joann G. Elmore, Paavali A. Hannikainen, Anna Marie Chang, Mandy Hill, Ryan M. Huebinger, Ahamed H. Idris, Katherine Koo, Shu-Xia Li, Samuel Mcdonald, Graham Nichol, Kelli N. O'Laughlin, Ian D. Plumb, Michelle Santangelo, Sharon Saydah, Kari A. Stephens, Arjun K. Venkatesh, Robert A. Weinstein

Department of Emergency Medicine Faculty Papers

Background: While prior work examining severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern focused on hospitalization and death, less is known about differences in clinical presentation. We compared the prevalence of acute symptoms across pre-Delta, Delta, and Omicron.

Methods: We conducted an analysis of the Innovative Support for Patients with SARS-CoV-2 Infections Registry (INSPIRE), a cohort study enrolling symptomatic SARS-CoV-2-positive participants. We determined the association between the pre-Delta, Delta, and Omicron time periods and the prevalence of 21 coronavirus disease 2019 (COVID-19) acute symptoms.

Results: We enrolled 4113 participants from December 2020 to June 2022. Pre-Delta vs Delta …

Policy Implementation In Crisis: Lessons From The Philippines, Steven T. Zech, Joshua Eastin, Matteo Bonotti

Political Science Faculty Publications and Presentations

Like many countries, the Philippines faced severe economic, social, and political challenges during the COVID-19 pandemic. In March 2020 President Duterte issued an executive order announcing a national state of emergency that introduced a highly restrictive system for community quarantine and lockdown. While these measures led international observers to rank the Philippinesʼ pandemic response among the worldʼs most stringent, it is unclear whether subsequent health outcomes were sufficient to justify the severity. In this article, we evaluate discrepancies between COVID-19 policy goals and outcomes in the Philippines via a compelling but under-utilized method of democratic deliberation, the ‘mini-public’. The mini-public …

Evaluation Of Amnion Membrane Made Vascular Graft In Rat Model And Porcine Model, Xiaolong Wang

Master's Theses (2009 -)

Heart bypass surgery has become a common therapeutic strategy to save heart attack patients from death. However, there are issues with the availability of graft resources for patients who cannot use autologous vessels due to their health conditions. To solve this problem, this study aims to develop a small-diameter vascular graft based on the human decellularized amniotic membrane (DAM) as an alternative to autologous vessels. The human amniotic membrane was harvested from the placenta, obtained from consenting and de-identified donors, and decellularized to remove cellular components while preserving its extracellular matrix. Small-diameter vascular grafts were fabricated using the DAM as …

Addiction Prevention In Itasca County, Minnesota, Amanda Keech

Selected Social Change Portfolios in Prevention, Intervention, and Consultation

Goal Statement: The purpose and goal of this portfolio is to raise awareness regarding alcohol consumption by highlighting influential factors and prevention techniques in order to decrease excessive drinking rates for adults residing in Itasca County.

Significant Findings: Excessive drinking is present in 23% of the population in Itasca County (County Health Ranking & Roadmaps, 2018). Excessive alcohol consumption is a growing public health issue resulting from multiple systemic, cultural, governmental, and individual risk factors that are present within the rural community. Individual risk factors include food insecurity, poverty, housing instability, a family history, trauma, medical issues, and the presence …

Relationship Between The Demographic Factors Of People Living In Cholera Endemic Areas And Their Knowledge Towards The Preventive Measures Against The Disease, Zainab Mohamed Mahmmod, Tabarek Ayad Noori, Ali Najm Abdullah

Al-Nisour Journal for Medical Sciences

Cholera is an infectious, acute bacterial disease caused by Vibrio Cholera. Watery diarrhea is the predominant clinical sign of the disease. Around the world, it is thought to be responsible for up to 4 million cases annually. This digestive contagious is characterized by high-volume fluid loss and electrolyte disturbances that may advance to hypovolemic shock and finally death. This survey study seeks to discover how well-informed, how individuals in Diyala, Iraq, feel about cholera epidemics, and how they behave in practice. In the present research, there were a total of 272 participants, with a mean age of 20 to 29 …

Lung And Colorectal Cancer Disparities In Appalachian Kentucky: Spatial Analysis On The Influence Of Education And Literacy, Nicole Robertson Mph, Todd Burus, Lauren Hudson, Pamela C. Hull, Lee Park, Nathan L. Vanderford

Markey Cancer Center Faculty Publications

Low educational attainment and high cancer incidence and mortality rates have long been a challenge in Appalachian Kentucky. Prior studies have reported disparities in cancer incidence and mortality between Appalachian and non-Appalachian populations, but the influence of education on this disparity has not been extensively studied. Herein, all cancers and two cancer sites with available screenings (colorectal and lung) were joined with education indicators (educational attainment and literacy) and one geographic indicator across all 120 Kentucky counties. This dataset was used to build choropleth maps and perform simple linear and spatial regression to assess statistical significance and to measure the …

Nac1 Confines Virus‐Specific Memory Formation Of Cd4+ T Cells Through The Rock1‐Mediated Pathway, Liqing Wang, Hao-Yun Peng, Jugal Kishore Das, Anil Kumar, Yijie Ren, Darby J. Ballard, Xiaofang Xiong, Wen Yang, Xingcong Ren, Paul De Figueiredo, Jin-Ming Yang, Jianxun Song

Markey Cancer Center Faculty Publications

Nucleus accumbens‐associated protein 1 (NAC1), a transcriptional cofactor, has been found to play important roles in regulating regulatory T cells, CD8 + T cells, and antitumor immunity, but little is known about its effects on T‐cell memory. In this study, we found that NAC1 expression restricts memory formation of CD4 + T cells during viral infection. Analysis of CD4 + T cells from wild‐type (WT) and NAC1‐ deficient (−/−) mice showed that NAC1 is essential for T‐cell metabolism, including glycolysis and oxidative phosphorylation, and supports CD4 + T‐cell survival in vitro. We further demonstrated that a deficiency of NAC1 downregulates …

Women And Girls Bear Brunt Of Water And Sanitation Crisis – New Unicef-Who Report

Saudi Medical Journal

No abstract provided.

No Interest In Being Cynical: Conflicting Versus Corresponding Interests Track Variability In The Link Between Personal Control And Cynicism, Bryan Kwok Cheng Choy

Dissertations and Theses Collection (Open Access)

Recent literature indicates that a lack of personal control negatively predicts (social) cynicism, a negative view of others as self-interested and exploitative (Stavrova & Ehlebracht, 2018a, 2019). Despite the ostensibly robust nature of this relationship, I propose that the strength of the link between personal control and cynicism could be more variable than extant findings have suggested. In particular, I argue that variability in the controlcynicism link may be tracked (i.e., moderated) by the extent to which actors in a situation have corresponding or conflicting interests, with the effect of control on cynicism being attenuated when actors are perceived to …

Conjunctivitis, Neonatal, Children's Mercy Kansas City

Clinical Pathways (Formally Known As Care Process Models)

No abstract provided.

Exploring The Interactions Between Sars-Cov-2 And Host Proteins, Sojan Shrestha

School of Biological Sciences: Dissertations, Theses, and Student Research

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the current pandemic, Coronavirus Disease 2019 (COVID-19). SARS-CoV-2 is considered to be of zoonotic origin; it originated in non-human animals and was transmitted to humans. Since the early stage of the pandemic, however, the evidence of transmissions from humans to animals (reverse zoonoses) has been found in multiple animal species including mink, white-tailed deer, and pet and zoo animals. Furthermore, secondary zoonotic events of SARS-CoV-2, transmissions from animals to humans, have been also reported. It is suggested that non-human hosts can act as SARS-CoV-2 reservoirs where accumulated …

Arsenic Metabolism, Diabetes Prevalence, And Insulin Resistance Among Mexican Americans: A Mendelian Randomization Approach, Margaret C Weiss, Yu-Hsuan Shih, Molly Scannell Bryan, Brian P Jackson, David Aguilar, Eric L Brown, Goo Jun, Craig L Hanis, Maria Argos, Robert M Sargis

Faculty, Staff and Student Publications

BACKGROUND: Differences in arsenic metabolism capacity may influence risk for type 2 diabetes, but the mechanistic drivers are unclear. We evaluated the associations between arsenic metabolism with overall diabetes prevalence and with static and dynamic measures of insulin resistance among Mexican Americans living in Starr County, Texas.

METHODS: We utilized data from cross-sectional studies conducted in Starr County, Texas, from 2010-2014. A Mendelian randomization approach was utilized to evaluate the associations between arsenic metabolism and type 2 diabetes prevalence using the intronic variant in the arsenic methylating gene, rs9527, as the instrumental variable for arsenic metabolism. to further assess mechanisms …

Clonal Hematopoiesis Is Associated With Protection From Alzheimer's Disease, Hind Bouzid, Julia A Belk, Max Jan, Yanyan Qi, Chloé Sarnowski, Sara Wirth, Lisa Ma, Matthew R Chrostek, Herra Ahmad, Daniel Nachun, Winnie Yao, Alexa Beiser, Alexander G Bick, Joshua C Bis, Myriam Fornage, William T Longstreth, Oscar L Lopez, Pradeep Natarajan, Bruce M Psaty, Claudia L Satizabal, Joshua Weinstock, Eric B Larson, Paul K Crane, C Dirk Keene, Sudha Seshadri, Ansuman T Satpathy, Thomas J Montine, Siddhartha Jaiswal

Faculty, Staff and Student Publications

Clonal hematopoiesis of indeterminate potential (CHIP) is a premalignant expansion of mutated hematopoietic stem cells. As CHIP-associated mutations are known to alter the development and function of myeloid cells, we hypothesized that CHIP may also be associated with the risk of Alzheimer's disease (AD), a disease in which brain-resident myeloid cells are thought to have a major role. To perform association tests between CHIP and AD dementia, we analyzed blood DNA sequencing data from 1,362 individuals with AD and 4,368 individuals without AD. Individuals with CHIP had a lower risk of AD dementia (meta-analysis odds ratio (OR) = 0.64, P …

Prevalence Of Leprosy In Lower -Middle- Income And Upper -Middle-Income Countries: A Secondary Data Analysis, Venkatesh Ramaswamy Naik, Rishikha Jeyapal

Manipal Journal of Nursing and Health Sciences

Abstract

To Study the Prevalence of Leprosy in Lower -Middle- Income and Upper -Middle-Income Countries

Introduction: Leprosy is an infectious disease affecting the nerves causing loss of sensation of touch and pain in the affected areas. The prevalence of leprosy in different countries has changed over time with the governments of the respective countries intensifying their efforts and working on various public health programs. Objective: This study aimed to look into the prevalence rates of leprosy per 1000000 population in lower-middle-income and upper-middle-income countries. Material and Method: The prevalence rates per 1000000 population were obtained from the Global Health Observatory …

Impact Of Age And School Instruction Mode On Children’S Occupations Early In The Covid-19 Pandemic: A Longitudinal Survey Study, Samuel Nemanich, Gabriel M. Velez, Ann Millard, Anne Pleva

Occupational Therapy Faculty Research and Publications

Importance: The coronavirus disease 2019 (COVID-19) pandemic disrupted participation in routines and daily activities. It is unclear how children reengaged in activities during the pandemic, particularly as a new school year began. Differences in school instruction mode (in person, hybrid, or remote) during the pandemic could further affect activity participation.

Objective: To examine changes in sedentary and nonsedentary activity participation in children and to determine whether school instruction mode was associated with participation.

Setting: Home-based survey of U.S. residents.

Participants: Parents of 208 children (46.2% female) between ages 5 and 18 yr were surveyed at two waves: March through April …

An Exploratory Study Of The Impact Of Quality Management Practices On Data Integrity Fda-483 Observations Received By Pharmaceutical Manufacturers In Florida, Sarah Mary Christie

Theses and Dissertations

Quality management systems and regulatory compliance have been studied in academic and practitioner settings (Andersson et al., 2006; Beattie & Sohal, 1999; Berrouiguet, 2013; McDowall & Ratcliff, 2016; Unger, 2019; Wechsler, 2019). While research has been performed on both topics independently, there has not been a definitive analysis of the relationship between quality management practices and regulatory compliance, especially in an FDA-regulated manufacturing environment. This research study attempts to link quality management practices and regulatory compliance and provides valuable insights for working managers on the practitioner level.

Staphylococcus Aureus Bacteremia In Pediatric Patients: Uncovering A Rural Health Challenge, Kyle J Whittington, Sara M Malone, Patrick G Hogan, Faria Ahmed, Jessieann Flowers, Grace Milburn, John J Morelli, Jason G Newland, Stephanie A Fritz

2020-Current year OA Pubs

BACKGROUND:

METHODS: To investigate factors influencing

RESULTS: Of 251 patients, 69 (27%) were from rural areas; 28 (11%) were initially admitted to an OSH. Treatment failure occurred in 39 (16%) patients. Patients from rural areas were more likely to be infected with methicillin-resistant

CONCLUSIONS: Children from rural areas face barriers to specialized health care. These challenges may contribute to severe illness and worse outcomes among children with

Healthcare Costs Of Clostridioides Difficile Infection In Commercially Insured Younger Adults, John M Sahrmann, Margaret A Olsen, Matthew R Keller, Holly Yu, Erik R Dubberke

2020-Current year OA Pubs

In a US adult population aged <65 years, attributable costs due to

Safety And Efficacy Of Ceftolozane/Tazobactam Plus Metronidazole Versus Meropenem From A Phase 2, Randomized Clinical Trial In Pediatric Participants With Complicated Intra-Abdominal Infection, Carl-Christian A. Jackson, Jason Newland, Nataliia Dementieva, Julia Lonchar, Feng-Hsiu Su, Jennifer A. Huntington, Mekki Bensaci, Myra W. Popejoy, Matthew G. Johnson, Carisa De Anda, Elizabeth G. Rhee, Christopher J. Bruno

2020-Current year OA Pubs

BACKGROUND: Ceftolozane/tazobactam, a cephalosporin-β-lactamase inhibitor combination, is approved for the treatment of complicated urinary tract infections and complicated intra-abdominal infections (cIAI). The safety and efficacy of ceftolozane/tazobactam in pediatric participants with cIAI were assessed.

METHODS: This phase 2 study (NCT03217136) randomized participants to either ceftolozane/tazobactam+metronidazole or meropenem for treatment of cIAI in pediatric participants (<18 years). The primary objective was to assess the safety and tolerability of intravenous ceftolozane/tazobactam+metronidazole. Clinical cure at end of treatment (EOT) and test of cure (TOC) visits were secondary end points.

RESULTS: The modified intent-to-treat (MITT) population included 91 participants (ceftolozane/tazobactam+metronidazole, n = 70; meropenem, n = 21). Complicated appendicitis was the most common diagnosis (93.4%); Escherichia coli was the most common pathogen (65.9%). Adverse events (AEs) occurred in 80.0% and 61.9% of participants receiving ceftolozane/tazobactam+metronidazole …

Immune Effector Cell-Associated Hemophagocytic Lymphohistiocytosis-Like Syndrome, Melissa R Hines, Tristan E Knight, Kevin O Mcnerney, Mark B Leick, Tania Jain, Sairah Ahmed, Matthew J Frigault, Joshua A Hill, Michael D Jain, William T Johnson, Yi Lin, Kris M Mahadeo, Gabriela M Maron, Rebecca A Marsh, Sattva S Neelapu, Sarah Nikiforow, Amanda K Ombrello, Nirav N Shah, Aimee C Talleur, David Turicek, Anant Vatsayan, Sandy W Wong, Marcela V Maus, Krishna V Komanduri, Nancy Berliner, Jan-Inge Henter, Miguel-Angel Perales, Noelle V Frey, David T Teachey, Matthew J Frank, Nirali N Shah

Faculty, Staff and Student Publications

T cell-mediated hyperinflammatory responses, such as cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), are now well-established toxicities of chimeric antigen receptor (CAR) T cell therapy. As the field of CAR T cells advances, however, there is increasing recognition that hemophagocytic lymphohistiocytosis (HLH)-like toxicities following CAR T cell infusion are occurring broadly across patient populations and CAR T cell constructs. Importantly, these HLH-like toxicities are often not as directly associated with CRS and/or its severity as initially described. This emergent toxicity, however ill-defined, is associated with life-threatening complications, creating an urgent need for improved identification and optimal …

Clinical Experience And Adverse Drug Events Of Favipiravir Use In Real-World Data, Thailand, Chotirat Nakaranurack, Wichai Santimaleeworagun, Gompol Suwanpimolkul, Benjabhorn Weeraphon, Watsa Charoenwaiyachet, Pattama Torvorapanit

The Thai Journal of Pharmaceutical Sciences

Favipiravir is one of the antiviral agents for coronavirus disease 2019 (COVID-19). This study described the adverse drug events (ADEs) and factors associated with aspartate transaminase (AST) or alanine transaminase (ALT) elevation in Thai COVID-19 patients who received favipiravir. A cross-sectional study was conducted at King Chulalongkorn Memorial Hospital, Thailand, among patients aged 18 years old or over with confirmed COVID-19, admitted between April and June 2021, and received favipiravir for COVID-19 treatment. Clinical pharmacists followed up ADEs after discharge from the hospital by phone. Seven hundred and fifteen COVID-19 patients were included in the study. Pharmacists could complete follow-ups …

Long-Chain Fatty Acid Sensing And Catabolism In Commensal Escherichia Coli Impact Murine Gut Colonization, Tessa Carolina Cox

Theses and Dissertations

The gastrointestinal tract is home to trillions of microbes that collectively influence host physiology, immunity, nutrient metabolism, and infectious disease. The overgrowth of naturally-occurring Escherichia coli in the gut is a common signifier of microbiome dysfunction and occurs in many chronic diseases including obesity. Recent studies have shown that higher fat intake is associated with increased gut E. coli growth. However, it remains unknown whether gut E. coli utilize lipids such as long chain fatty acids (LCFAs) as carbon sources to colonize the mammalian gut. Therefore, the central objective of my dissertation was to utilize bacterial genetics and various mouse …

Bayesian Spatial And Spatio-Temporal Models For Complex Data Sets, Rongjie Huang

Theses and Dissertations

The cost of testing for infectious diseases can be high, and analyzing large amounts of historical data to forecast disease prevalence can be a time-consuming process. Group testing techniques offer a way to decrease the expenses associated with testing, but this comes at the cost of increased complexity of the data structure due to grouping and imperfect testing when compared to individual-level testing. In this dissertation research, we propose two Bayesian mixed effects spatial group testing regression models: one for areal data and the other for point process data. The former model utilizes a conditional autoregressive (CAR) prior for areal …

People Over Profits: Why A Private Right Of Action In The Occupational Safety And Health Act Is Necessary During The Covid-19 Pandemic, Olivia Nevola

Cardozo Journal of Equal Rights & Social Justice

The Occupational Safety and Health Act (OSHA) lacks a private right of action, leaving employees without direct legal recourse against employers for violations, despite the critical need for such protections, especially highlighted by the COVID-19 pandemic. The note argues that amending the Act to include an explicit private right of action would enhance enforcement, hold employers accountable, and provide necessary remedies for workers, supplementing the insufficient administrative process and workers' compensation laws.

How Post-Immunization Covid-19 Context Affected Residents’ Evacuation Behavior During Hurricane Ida, Amy Polen, Jennifer Collins, Elizabeth Dunn, Stephen Murphy, Isabelle Jernigan, Killian Mcsweeney, Yi Jie Zhu

School of Geosciences Faculty and Staff Publications

Since the onset of the COVID-19 pandemic, decision-making during disasters fundamentally changed to accommodate the combined risks of hurricanes and infectious diseases. Prior research conducted in 2020 by Collins et al. examined how individuals changed their intended evacuation decision-making during the pandemic or their actual evacuation decisions during Hurricanes Laura and Sally. Hurricane Ida provided further data on evacuation decision-making when vaccinations and masks were widely available. A digital survey was disseminated to individuals affected by Hurricane Ida in 2021. Respondents provided information about their actual evacuation choices and perceptions of public shelters and COVID-19 risks. In comparison with the …

Leveraging Church Environments To Promote Rural Physical Activity And Healthy Eating, Kelsey Rothera Day

Theses and Dissertations

Rural residents experience a greater burden of chronic disease related to physical inactivity and poor diet than their urban counterparts. A promising strategy to improve these health behaviors in rural areas is to leverage existing structures that may support physical activity and healthy eating, such as churches, in public health interventions. Three studies were conducted as part of this dissertation. They were designed to: 1) examine whether the walkability and healthy food density of neighborhoods surrounding rural and urban churches are associated with race, socioeconomic status, and rural/urban status; 2) examine rural church leaders’ views on the role of faith-based …

Patient Experiences And Disparities In Telehealth Hiv Care During The Covid-19 Pandemic: Study Results From The Southern United States, Valerie Yelverton

Theses and Dissertations

Background: To maintain HIV care continuity during the COVID-19 pandemic, most HIV care facilities in the United States adopted telehealth. However, not everyone was participating in telehealth equally. This dissertation seeks to understand experiences with and the use of telehealth in HIV care, and decision processes guiding the selection of visit type during the COVID-19 pandemic.

Methods: Qualitative interviews explored people living with HIV’s (PWH) and HIV care provider’s experiences with telehealth HIV care and visit type decision processes. Quantitative analyses of electronic health record (EHR) data characterized patterns of and disparities in telehealth HIV care during the COVID-19 pandemic. …

School Of Biological Sciences News, 2023, School Of Biological Sciences

School of Biological Sciences News

Alumni newsletter of Illinois State University's School of Biological Sciences.

Development Of Cancer Surveillance Guidelines In Ataxia Telangiectasia: A Delphi-Based Consensus Survey Of International Experts, Renata Neves, Blanca De Dios Perez, Rafal Panek, Sumit Jagani, Sophie Wilne, Jayesh M Bhatt, Caterina Caputi, Emilia Cirillo, David J Coman, Gregor Dückers, Donald L Gilbert, Mary Kay Koenig, Lobna Mansour, Elizabeth Mcdermott, Micaela Pauni, Claudio Pignata, Susan L Perlman, Oscar Porras, Mariela Betina Porto, Katherine Schon, Pere Soler-Palacin, Sam Nick Russo, Masatoshi Takagi, Marc Tischkowitz, Claire Wainwright, Madhumita Dandapani, Cristine Glazebrook, Mohnish Suri, William P Whitehouse, Robert A Dineen

Faculty, Staff and Student Publications

BACKGROUND/OBJECTIVES: Ataxia telangiectasia (A-T) is a multiorgan disorder with increased vulnerability to cancer. Despite this increased cancer risk, there are no widely accepted guidelines for cancer surveillance in people affected by A-T. We aimed to understand the current international practice regarding cancer surveillance in A-T and agreed-upon approaches to develop cancer surveillance in A-T.

DESIGN/METHODS: We used a consensus development method, the e-Delphi technique, comprising three rounds. Round 1 consisted of a Delphi questionnaire and a survey that collected the details of respondents' professional background, experience, and current practice of cancer surveillance in A-T. Rounds 2 and 3 were designed …