Digital Commons Network^™

Electrospun Ethyl Cellulose Nanofibers With Phase Change Materials: Designing Temperature-Responsive Drug Delivery Systems, Michael Wildy

Theses and Dissertations

In this study, ethyl cellulose (EC) nanofibers loaded with either Rhodamine B (RhB) or Doxorubicin HCl (DOX) and phase change materials (PCM) were fabricated by blend electrospinning. EC is a cellulose derivative widely used as an excipient in the pharmaceutical industry and an ideal polymer for controlled drug release. Lauric acid (LA) and stearic acid (SA) were used as a material with a melting point close to physiological body temperature. Good drug-polymer compatibility and an amorphous distribution of drugs were shown by Fourier transform infrared spectroscopy, differential scanning calorimetry, and X-ray diffraction. The release rate of RhB was shown to …

The Implications Of Ferroptosis In Antibiotic Resistance, Marysol Hohl

Senior Honors Theses

Bacterial infections in the United States are becoming increasingly resistant to existing antibiotic treatments. Due to projected increases in resistance and the recent decrease in novel antibacterials, experts have determined that the United States is in the “post-antibiotic era.” The scientific community has failed to resolve resistance despite the continual discovery of new antibiotic compounds. In the past decade, a novel form of cell death called ferroptosis has been implicated in antibiotic treatment by employing the use of nanotechnology. This literature review will describe the problem of bacterial resistance and demonstrate how current research is pioneering a new age of …

Testosterone Is Positively Associated With Coronary Artery Calcium In A Low Cardiovascular Disease Risk Population, Benjamin Trumble, Jacob Negrey, Stephanie V. Koebele, Randall C. Thompson, L. Samuel Wann, Adel H. Allam, Bret Beheim, M. Linda Sutherland, James D. Sutherland, Daniel Eid Rodriguez, David E. Michalik, Chris J. Rowan, Guido P. Lombardi, Angela R. Garcia, Daniel K. Cummings, Edmond Seabright, Sarah Alami, Thomas S. Kraft, Paul L. Hooper, Kenneth Buetow, Andrei Irimia, Margaret Gatz, Jonathan Stieglitz, Michael D. Gurven, Hillard Kaplan, Gregory S. Thomas, Tsimane Health And Life History Project Teams

ESI Publications

Background

In industrialized populations, low male testosterone is associated with higher rates of cardiovascular mortality. However, coronary risk factors like obesity impact both testosterone and cardiovascular outcomes. Here, we assess the role of endogenous testosterone on coronary artery calcium in an active subsistence population with relatively low testosterone levels, low cardiovascular risk and low coronary artery calcium scores.

Methodology

In this cross-sectional community-based study, 719 Tsimane forager-horticulturalists in the Bolivian Amazon aged 40+ years underwent computed tomography (49.8% male, mean age 57.6 years).

Results

Coronary artery calcium levels were low; 84.5% had no coronary artery calcium. Zero-inflated negative binomial models …

Quantifying Non-Gaussian Intermittent Fluctuations In Physiology: Multiscale Probability Density Function Analysis Using The Savitzky-Golay Detrending, Madhur Mangalam, Damian G. Kelty-Stephen, Eiichi Watanabe, Ken Kiyono

Journal Articles

When measuring physiological data, the central limit theorem typically implies a consistent variance, resulting in data that closely follow a Gaussian distribution. However, physiological measurements often deviate from this expectation, increasing variance due to nonlinear correlations across various scales. The challenge lies in testing these tails, which comprise only rare and extreme values. We introduce multiscale probability density function (PDF) analysis, a method that estimates this non-Gaussianity parameter for physiological fluctuations in each of multiple timescales. We gain valuable insights into the observed distributions with heavier tails and nonlinear correlations by exploring the relationship between non-Gaussianity and logarithmic scale. To …

Ai And Concerns On Bias And Correctness In Engineering, Stacy Bjorgaard

AI Assignment Library

This is a two-part assignment. In the first part, students discuss various scenarios relating to use of AI and potential issues of bias in class. In the second part, students examine the answers AI gives to basic questions in several engineering fields and compare these to expert answers for correctness.

Bilateral Differences In Vascular Stiffness And Blood Pressure Of Female College Tennis Players And Controls, Chanhtel E. Thongphok, Abena O. Gyampo, Anneli O. Ramolins, Elianna G. Hills, Claire E. Coates, Stephen J. Ives

International Journal of Exercise Science: Conference Proceedings

Vascular stiffness is highly correlated to cardiovascular disease (CVD) and has been attenuated by regular aerobic exercise in older adults. Additionally, body composition strongly predicts vascular stiffness and CVD risk. Previous research has documented that bilateral differences in shear stress lead to differences in vascular endothelial function in tennis players. However, whether this translates into bilateral differences in vascular stiffness and blood pressure remains to be elucidated. The SphygmoCor is a gold standard for assessing arterial stiffness but is not readily accessible. In comparison, the TicWatch GTH Pro, which uses the SphygmoCor algorithm to provide a cardiovascular health (CVH) score …

Effects Of Aging On Post-Exercise Oxygen Consumption: A Preliminary Study, Steven Klepacz

Health, Exercise, and Sports Sciences ETDs

Aging and excess post-exercise oxygen consumption (EPOC) is something that has not been adequately studied. Studies looking at EPOC mostly are compiled of young college age individuals. Aging in humans is a topic of much research with still more to be learned. The study in this paper attempts to answer the question of whether age affects EPOC when performing a certain exercise. Preliminary findings based on general age-related research suggest the possibility. This thesis will explore the current research related to age and EPOC, analyze the findings, and discuss additional avenues for future research.

Improving The Thermal Comfort Of Industrial Building Using Insulation Materials, Hosam Amr, Androw Khairy

Journal of Engineering Research

industrial buildings are one of the larges used t worldwide, and every day it grows noticeably in many different forms of projects so , the introduction of insulation materials was very essential, and their development for enhancing a variety of parameters such as thermal comfort inside the building which became one of the very important aspects in industrial buildings. Design of any industrial building should be to the lowest cost keeping in consideration importance of thermal comfort and its contribution in the productivity improvement of the workers as well as the administrative employee as well as reducing the high costs …

Improving The Thermal Comfort Of Industrial Building Using Insulation Materials, Hosam Amr, Androw Khairy

Journal of Engineering Research

industrial buildings are one of the larges used t worldwide, and every day it grows noticeably in many different forms of projects so , the introduction of insulation materials was very essential, and their development for enhancing a variety of parameters such as thermal comfort inside the building which became one of the very important aspects in industrial buildings. Design of any industrial building should be to the lowest cost keeping in consideration importance of thermal comfort and its contribution in the productivity improvement of the workers as well as the administrative employee as well as reducing the high costs …

Piano Majors Showcase

Printed Performance Programs (PDF Format)

No abstract provided.

Assessing The Validity Of Several Heart Rate Monitors In Wearable Technology While Mountain Biking, Bryson Carrier, Robert W. Salatto, Dustin W. Davis, Jacquelyn Sertic, Brenna Barrios, Graham R. Mcginnis, Tedd Girouard, Benjamin E. Burroughs, James W. Navalta

International Journal of Exercise Science

International Journal of Exercise Science 16(7): 1440-1450, 2023. Purpose: This study sought to assess the validity of several heart rate (HR) monitors in wearable technology during mountain biking (MTB), compared to the Polar H7® HR monitor, used as the criterion device. Methods: A total of 20 participants completed two MTB trials while wearing six HR monitors (5 test devices, 1 criterion). HR was recorded on a second-by-second basis for all devices analyzed. After data processing, validity measures were calculated, including 1. error analysis: mean absolute percentage errors (MAPE), mean absolute error (MAE), and mean error (ME), and 2. Correlation analysis: …

Is There Clarity On The Horizon For Peri‐Operative Oxygen Therapy?, D. Martin, A. Cumpstey

Peninsula Medical School

No abstract provided.

The Impact Of Creativity On Alpha Activity, Serena Bruneaux

EKU Libraries Research Award for Undergraduates

No abstract provided.

Electrospun Nanofibers: Shaping The Future Of Controlled And Responsive Drug Delivery., Michael Joshua Wildy, Ping Lu

College of Science & Mathematics Departmental Research

Electrospun nanofibers for drug delivery systems (DDS) introduce a revolutionary means of administering pharmaceuticals, holding promise for both improved drug efficacy and reduced side effects. These biopolymer nanofiber membranes, distinguished by their high surface area-to-volume ratio, biocompatibility, and biodegradability, are ideally suited for pharmaceutical and biomedical applications. One of their standout attributes is the capability to offer the controlled release of the active pharmaceutical ingredient (API), allowing custom-tailored release profiles to address specific diseases and administration routes. Moreover, stimuli-responsive electrospun DDS can adapt to conditions at the drug target, enhancing the precision and selectivity of drug delivery. Such localized API …

Deweyan “Soul” As Conceived In His Early Work, Becky L. Noël Smith, Randy Hewitt

Education and Culture

The term “soul” is found throughout John Dewey’s work, particularly when discussing self-realization and meaningfulness. Soul can be easily associated with religious connotations, and yet it is well accepted that he did not imply such. So, then, what did he mean? In his early writings, he shifted away from theologically inspired language and toward a conception composed in naturalized terms. This, no doubt, can be confusing to uninitiated readers. While extensive analyses have been written on his philosophy of spirit and metaphysics, they can leave one wondering: what is a conception of soul that is consistent with Dewey’s philosophy of …

Soft Microreactors For The Deposition Of Microstructures And The Related Surface Chemistries Of Polymeric Materials, Jessica Wagner

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

The precise control over small volumes of liquids is of great interest to various fields such as biotechnology, drug development, and diagnostics. Working at small scales reduces cost, time, and waste, which is why microfluidic lab-on-chip technologies have become popular in a wide range of industries and applications. Additionally, there are differences in properties such as mass transport and heat dissipation at the micron scale compared to in bulk. Microfluidic devices contain several interfaces to consider when preparing to fabricate devices. The substrate/device, substrate/solution, and solution/device interfaces are all of importance and must carefully be tuned depending on the desired …

Development Of An Angiogenic Tissue-On-A-Chip Microenvironment, Eric Stuehr

Master's Theses

Preclinical testing is necessary to investigate the safety and efficacy of novel therapeutics before moving to clinical trials, yet approximately 90% of these therapies fail once tested in humans. This has led to increased interest in developing robust preclinical models that accurately mimic the complex human in vivo physiology. Microfluidic devices that can introduce dynamic conditions to 3D cell/organoid cultures, also known as tissue-on-a-chip, have emerged as physiologically relevant in vitro preclinical models that can achieve high throughput screening of therapeutics. The research presented here aimed to develop an angiogenic environment within a novel microfluidic device to stimulate formation of …

The Federal Circuit’S Experimental Prism, Jeremy W. Bock

Fordham Law Review

Whether the U.S. Court of Appeals for the Federal Circuit is succeeding in its role as the steward of decisional patent law has been the subject of considerable debate and many empirical studies for the past forty years. Based on these studies, some observers have expressed skepticism of the utility of that court’s exclusive, nationwide jurisdiction over patent appeals. But the substantial body of empirical literature on the Federal Circuit has been viewed largely from a single vantage point, one that attributes any negative or undesirable outcomes to the court’s specialization. This Article argues that there is another way to …

Urban Versus Lake Impacts On Heat Stress And Its Disparities In A Shoreline City, T. C. Chakraborty, Jiali Wang, Yun Qian, William Pringle, Zhao Yang, Pengfei Xue

Michigan Tech Publications

Shoreline cities are influenced by both urban-scale processes and land-water interactions, with consequences on heat exposure and its disparities. Heat exposure studies over these cities have focused on air and skin temperature, even though moisture advection from water bodies can also modulate heat stress. Here, using an ensemble of model simulations covering Chicago, we find that Lake Michigan strongly reduces heat exposure (2.75°C reduction in maximum average air temperature in Chicago) and heat stress (maximum average wet bulb globe temperature reduced by 0.86°C) during the day, while urbanization enhances them at night (2.75 and 1.57°C increases in minimum average air …

Dominant Negative Variants In Ikzf2 Cause Ichad Syndrome, A New Disorder Characterized By Immunodysregulation, Craniofacial Anomalies, Hearing Impairment, Athelia, And Developmental Delay, Arezoo Mohajeri, Maryam Vaseghi-Shanjani, Jill A Rosenfeld, Gui Xiang Yang, Henry Lu, Mehul Sharma, Susan Lin, Areesha Salman, Meriam Waqas, Mahshid Sababi Azamian, Kim C Worley, Kate L Del Bel, Frederick K Kozak, Ronak Rahmanian, Catherine M Biggs, Kyla J Hildebrand, Seema R Lalani, Sarah K Nicholas, Daryl A Scott, Sara Mostafavi, Clara Van Karnebeek, Erika Henkelman, Jessica Halparin, Connie L Yang, Linlea Armstrong, Undiagnosed Diseases Network, Anna Lehman Care 4 Rare Canada Consortium, Stuart E Turvey

Faculty, Staff and Students Publications

Background:

Helios (encoded by IKZF2), a member of the Ikaros family of transcription factors, is a zinc finger protein involved in embryogenesis and immune function. Although predominantly recognized for its role in the development and function of T lymphocytes, particularly the CD4⁺ regulatory T cells (Tregs), the expression and function of Helios extends beyond the immune system. During embryogenesis, Helios is expressed in a wide range of tissues, making genetic variants that disrupt the function of Helios strong candidates for causing widespread immune-related and developmental abnormalities in humans.

Methods:

We performed detailed phenotypic, genomic, and functional investigations on …

Divulging Two Decades Of Multimedia Applications In Biology Education, Khairul Hafezad Abdullah

Jurnal Inovasi Pendidikan IPA

Biology is an indispensable component of Science, Technology, Engineering, and Mathematics (STEM) education. Accordingly, effective biology teaching necessitates multimedia to assist students in fathoming complex scientific themes. This study aims to scrutinise the bibliometrics of preceding publications on multimedia applications in biology education from the Scopus and Web of Science databases. This study explores descriptive publishing patterns and the emergence of academic discourse about multimedia applications in biology education using ScientoPy and VOSviewer. The results reveal publications on this topic have been volatile, with less than ten publications in both databases. The United States has bested others as the most …

Synchronized Communication Used In Collaborative Humanoid Robots With Datacenter Applications, Fatih Dincer, Ahmad Byagowy

UBT International Conference

This manuscript is to describe a communication method used to operate data center related applications where multiple robots are required. In this configuration one of the robots is considered as the leader while the other one performs as a follower. The operations performed from the collective operation of the two robots aim to reach a coherence to allow applications that require multiple robots to be performed seamlessly. The development of this work was based on humanoid robots though it can be expanded to any robot platform based on a given application.

International Conference On Mechatronic, University For Business And Technology - Ubt

UBT International Conference

UBT Annual International Conference is the 12th international interdisciplinary peer reviewed conference which publishes works of the scientists as well as practitioners in the area where UBT is active in Education, Research and Development. The UBT aims to implement an integrated strategy to establish itself as an internationally competitive, research-intensive university, committed to the transfer of knowledge and the provision of a world-class education to the most talented students from all background. The main perspective of the conference is to connect the scientists and practitioners from different disciplines in the same place and make them be aware of the recent …

The Acute Impacts Of Resistance Training Performed With And Without Blood Flow Restriction On Lower Body Muscular Power, Justin Faller, Brian Thompson, Stephen Ives

International Journal of Exercise Science

International Journal of Exercise Science 16(6): 1320-1333, 2023. The American College of Sports Medicine recommends resistance training using at least 70% one repetition maximum to improve muscular strength and hypertrophy; however, these intensities may not be safe for all populations. A training technique that has been reported to elicit increases in strength and muscle size uses low intensity resistance training or low load training in combination with blood flow restriction (BFR) to the working muscle. Although the acute effects of BFR on muscle strength and size are well established, the effects of BFR on muscular power are not definitively known. …

Knowledge Integration In Domain-Informed Machine Learning And Multi-Scale Modeling Of Nonlinear Dynamics In Complex Systems, Phat K. Huynh

USF Tampa Graduate Theses and Dissertations

Nonlinear dynamical systems have been extensively used to model various phenomena in the changing world around us, especially in science and engineering fields. Thanks to breakthrough advancements in sensing technologies, an increasingly high volume of multi-modal sensor data has been collected, which enables us gain better insights into complex systems dynamics and build sophisticated data-driven machine-learning-based dynamic models without having the access to the underlying governing equations. However, integrating domain-specific knowledge in machine learning algorithms remains pivotal for various reasons: it promises enhanced predictive accuracy, better model interpretability, and increased generalizability. This dissertation delves into three core research questions, each …

Tolkien Dogmatics: Theology Through Mythology With The Maker Of Middle-Earth By Austin M. Freeman, Alex (Oleksiy) Ostaltsev

Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature

The powerful and highly informative definitions that Freeman applies to Tolkien’s Middle-earth phenomenon in the title of his book create a productive interpretational framework. Myth and mythology in Inklings’ writing were always understood, in an almost Jungian way, as a cultural paradigm flexible enough to embrace the free creativity of the playful human mind and a philosophical postulate, or credo, of the humanistic religious intuition of Christianity. In Freeman’s interpretation, Tolkien’s literary myth in some ways requires a theological background, which, in its turn, leads to inevitable dogma, a statement that reveals the sensitive mechanics of literary myth as it …

Neuroprotective Activity Of Enantiomers Of Salsolinol And N-Methyl-(R)-Salsolinol: In Vitro And In Silico Studies, Magdalena Kurnik-Łucka, Gniewomir Latacz, Adam Bucki, Mario Rivera-Meza, Nadia Khan, Jahnobi Konwar, Kamil Skowron, Marcin Kołaczkowski, Krzysztof Gil

Faculty, Staff and Student Publications

Salsolinol (1-methyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol) is a close structural analogue of dopamine with an asymmetric center at the C1 position, and its presence in vivo, both in humans and rodents, has already been proven. Yet, given the fact that salsolinol colocalizes with dopamine-rich regions and was first detected in the urine of Parkinson's disease patients, its direct role in the process of neurodegeneration has been proposed. Here, we report that

Determining The Protective Effect Of A Boron Adjuvanted Vaccine With An Experimental Infection Model In Mice, Zafer Sayin, Ali̇ Uslu, Özgür Özdemi̇r, Abdullah Başoğlu, Asli Balevi̇, Uçkun Sai̇t Uçan, Zeki̇ Aras, Osman Ergani̇ş

Turkish Journal of Veterinary & Animal Sciences

Boron is a required trace element for plants, humans, and animals and it has significant influence over biological functions and the immune system. Vaccines have aided humans in the control of many contagious diseases around the world. The success of global immunization campaigns may be possible with the development of effective and low-cost vaccines and adjuvants. For this reason, the present study aimed to determine the adjuvant activity of easily accessible boron compounds. In this study, six different vaccines were prepared, including inactive Staphylococcus aureus bacteria, boric acid, aluminum hydroxide, montanide ISA 50, and ISA 206, ISA 50 + boric …

A Descriptive Exploration Of Quality And Opportunities In Outdoor Urban Play Spaces: The Case Of Chicago Public Schools, Katherine Anne Varey

Dissertations

This study investigated the quality of children’s play spaces, both green and built, in and surrounding urban public schools in Chicago. Given children’s declining access to nature and the outdoors, especially in urban areas, the aim of the study was to both assess the current potential for high-quality outdoor experiences, as well as to uncover additional, low-cost, and low-burden opportunities that may exist for enhancing outdoor experiences. Based on a selected sample of 60 Chicago Public Schools, this mixed methods study employed quantitative ratings of play space and neighborhood quality, geographic information systems (GIS) mapping techniques to show distribution of …

Investigating The Influence Of Assessment Question Framing On Undergraduate Biology Student Preference And Affect, Jeremy L. Hsu, Noelle Clark, Kate Hill, Melissa Rowland-Goldsmith

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Nearly all undergraduate biology courses rely on quizzes and exams. Despite their prevalence, very little work has been done to explore how the framing of assessment questions may influence student performance and affect. Here, we conduct a quasi-random experimental study where students in different sections of the same course were given isomorphic questions that varied in their framing of experimental scenarios. One section was provided a description using the self-referential term “you”, placing the student in the experiment; another section received the same scenario that used classmate names; while a third section's scenario integrated counterstereotypical scientist names. Our results demonstrate …