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Therapeutic Implications Of The Gut-Cns Axis In Promoting Recovery Following Cervical Spinal Cord Injury, Jessica Wilson

Theses and Dissertations--Neuroscience

Nearly 60% of all spinal cord injuries (SCI) occur at the cervical level. These high-level injuries can interrupt the descending respiratory pathways required for breathing. Indeed, therapies in animal studies have been successful at restoring breathing after SCI; however, these interventions appear to be more effective at chronic time points. One potential cause for this observation is the impact of the injury on the gut microbiome. Neurotrauma can induce gut dysbiosis, an imbalance of pathogenic and beneficial gut microbiota, which has previously been shown to negatively impact the central nervous system (CNS) and impair recovery. We aimed to build upon …

Pre-Health Majors And Career Paths At Ud, Udayton

Pre-Health Resource Center Campus Communications

An overview of pre-health majors and career paths offered at University of Dayton.

The Role Of Insulin-Like Growth Factor I In The Development Of The Cerebellum In Euthyroid And Hypothyroid Mice, Prathibha Mangedarage

All Graduate Theses, Dissertations, and Other Capstone Projects

Thyroid hormone deficiency during development is known to cause anatomical defects in the cerebellum that lead to neurological deficits. It has been observed that insufficient thyroid hormone levels also decrease the levels of brain derived Insulin-like growth factor 1 (Igf-1). Given that the deficits caused by low Igf-1 levels are similar to those caused by low thyroid hormone, we designed this study to investigate if the deficits caused in the development of the cerebellum by low thyroid hormone levels may be due to the lack of sufficient Igf-1. We also sought to determine if ectopic over expression of Igf-1 in …

Residential Unit Design For Natural Ventilation In Tropical Multi-Family High-Rises With A Double-Loaded Corridor, Chalermwat Tantasavasdi, Natthaumporn Inprom

NAKHARA (Journal of Environmental Design and Planning)

This research investigates practical methods to improve the efficiency of natural ventilation in residential units of multi-family high-rises without additional areas. Typical studio- and one-bedroom-types of small units were redesigned using: 1) air post, 2) transom window, 3) buffer space with one corridor opening and 4) buffer space with two corridor openings. The simulation study using a CFD program to reveal that the indoor average air velocity coefficient (Cv ) in the best redesigned case (0.46) significantly improves from the base case (0.01). The paper demonstrates an example of application to an actual climate in Bangkok, Thailand. It was …

Aba-Mandated Instruction On Racism And Recent State Legislation Banning Such Instruction In University Classrooms: “Jim Crow” Redux, Bernard K. Freamon

Roger Williams University Law Review

No abstract provided.

Plant Sentience Revisited: Sifting Through The Thicket Of Perspectives, Paco Calvo, Miguel Segundo-Ortin

Animal Sentience

In our target article (Segundo-Ortin & Calvo 2023), we proposed the intriguing possibility of plant sentience, drawing parallels with non-human animal studies. This response aims to sift through the rich thicket of perspectives offered by our commentators. To do so, we assess the risks of employing double standards, as well as the tendencies of anthropomorphizing and zoomorphizing in plant studies. We also emphasize the need for clarity in linguistic and conceptual terms, examine the neurophysiological evidence for plant sentience, and discuss the ethical implications of such recognition.

Alzheimer’S Disease Genetics And Short-Chain Fatty Acid Treatment In Studies Of The Murine Gut Microbiome, Diana Zajac

Theses and Dissertations--Physiology

Elucidating the relationship of the gut microbiome in Alzheimer's Disease (AD) risk and pathogenesis is an area of intense interest. Since 60 to 80% of AD risk is related to genetics and APOE alleles represent the most impactful genetic risk factors for AD, their mechanism(s) of action are under intense scrutiny.

First, I conducted a study on APOE targeted replacement mice to investigate the impact of APOE alleles on the murine gut microbiome. The relative abundance of bacteria from the family Ruminococacceae and related genera increased with APOE2 status. The relative abundance of the class Erysipelotrichia increased with APOE4 status, …

2023-2024 Course Catalog, University Of Montana--Missoula. Office Of The Registrar

University of Montana Course Catalogs, 1895-2024

An annual catalog of courses and course descriptions offered at the University of Montana.

Reaching New Heights: 2022-23 Report Of The President, Office Of The President, Gonzaga University

Office of the President Publications

Each year, Gonzaga University's Office of the President produces an annual Report of the President. This publication that highlights just a few of the many accomplishments over the previous academic year, and is intended to convey gratitude to our Trustees and Regents, benefactors, and many supporters.

Producing Grnas For Use In Crispr-Cas9 Dna Editing Applications Via In Vivo T7 Rna Polymerase Transcription In Escherichia Coli., Christian A. Santiago

Honors Program Theses

The development of the CRISPR-Cas9 system is widely considered to be a breakthrough advancement in gene editing. Compared to traditional technologies, CRISPR is generally regarded as the most accessible, effective, and precise tool for inducing stable and inheritable gene edits in vivo. The CRISPR-Cas9 gene editing complex relies on the complementary binding of guide RNAs to specifically target a DNA sequence for endonuclease cleavage and mutagenesis. The production of gRNAs for use in CRISPR applications can become exceedingly complex and costly, as in vivo methodologies generally require the use of RNA polymerases that interfere with gRNA sequence identity and in …

Adult Learners With Learning Disabilities’ Motivation To Succeed In Higher Education Online Learning During Covid19, Sara Michelle Rodriguez

Walden Dissertations and Doctoral Studies

Many students had to transition to online learning due to the COVID-19 pandemic while other students were already enrolled in online education. Online study may hold additional struggles for students with learning disabilities. The problem addressed in this qualitative, phenomenological study was the motivating factors of online higher education students who have a learning disability during the COVID-19 pandemic. The theoretical foundation was Maslow’s hierarchy of needs. Data were gathered through 10 semistructured interviews and then analyzed through the thematic analysis yielding five themes: (a) lack of professional support, (b) resources, (c) support system, (d) consistent motivation, and (e) low …

Characterizing Cellular Injury And Inflammation With Aldob-/-Mouse Model Of Mafld, Andy Rashid

All Master's Theses

Metabolic-associated fatty liver disease (MAFLD) affects 1 in 3 people in the US and is a healthcare burden on the order of billions of dollars. MAFLD is characterized by pathological lipid accumulation in the liver, excess production of triglycerides and cholesterol, and export of LDL particles that raise serum lipid levels. These metabolic perturbations can lead to the development of liver fibrosis, chronic inflammation, and insulin resistance. Diagnosing MAFLD prior to fibrosis is crucial for successful intervention and prevention of advanced liver disease and other metabolic complications. Fructose-1Phospahte (F1P) accumulation from fructose overconsumption can drive hepatic lipogenesis and MAFLD progression. …

Natural Fractals And Facial Emotion Recognition, Nathaniel Joseph Pagel

Theses and Dissertations

The psychological benefits that come from visually processing natural imagery have been widely studied. The components of natural imagery that provoke positive responses are not fully understood. This study uses a mixed design approach to identify if the acute exposure to statistical fractal imagery, of both a high-range or mid-range complexity, affects cognitive workload, physiological arousal, and gaze patterns in the recognition and identification of emotions through facial expressions. Participants were undergraduate students fulfilling a partial course requirement (N = 87). Eye-tracking metrics were used to compare exposure to fractal complexities. Participants were randomly assigned to either be exposed to …

An Evaluation Of A School-Based School Connectedness Program, John G. Emmerich

Walden Dissertations and Doctoral Studies

In the United States, approximately 45% of high school students are either not engaged (28%) or actively disengaged (17%) in the academic process. Increasing a school's average student engagement yields an increase in reading and math achievement. This study evaluates a school connectedness program, Promoting Positive School Engagement (PPSE) program using a convergent mixed methods model to determine the degree of effectiveness measured by the Hemingway measure of adolescent connectedness instrument in an Urban, Midwest public middle school. Quantitative data were collected from 20 students who participated in the program and 20 students who did not (control group). Analyzed using …

Comparison Of Various Intermittent Fasting Dietary Interventions To The Ketogenic Dietary Interventions And Its Effects In Mitigating Hunger In Obese Adults, Aston Earl Francis Jr

Theses and Dissertations

There have been many dietary strategies that can be used for fat loss and the most recent popular dietary interventions have been intermittent fasting and the ketogenic diet. Intermittent fasting (IF) dietary interventions and the ketogenic diet (KD) are popular diets that claim to promote weight loss which has also been speculated to have enhanced benefits than caloric restriction. Although these dietary strategies are growing in popularity, it is unclear if the intervention can manage hunger, which may increase adherence. The purpose of this paper is to systematically review the literature on the impact of IF protocols compared to KD …

Voice Quality Assessment In Cases Of Vocal Fold Gaps After Single Growth Factor Injection, Amr Roushdyel Badrawy, Asmaa Abdel Hamid, Israa Eltaweel, Azza Abdel Aziz Azzam

Journal of Medicine in Scientific Research

In severe vocal fold (VF) lesions, deposits of disorganized, thick collagen bundles and little hyaluronic acid (HA) are deposited in the superficial layer of lamina propria (SLP). These changes lead to severe dysphonia and aspiration, which could be complicated by fatal pneumonia. Unfortunately, no specific treatment has been recognized due to unpredictable VF regeneration. Current progress in regenerative medicine has allowed the development of tissue engineering techniques using cells, scaffolds, and growth factors (GFs). Extrinsic GFs application could help in the induction of the regenerative process. The work aims to assess the voice quality after a single GF injection of …

Influence Of Exercise On Brown, White And Beige Adipocytes, Anna C. Covington

Graduate Student Theses, Dissertations, & Professional Papers

No abstract provided.

The Effect Of Fish Oil Supplementation On Resistance Training-Induced Adaptations, Jeffery L. Heileson, Steven B. Machek, Dillon R. Harris, Sara Tomek, Leticia C. De Souza, Adam J. Kieffer, Nicholas D. Barringer, Andrew Gallucci, Jeffrey S. Forsse, Leslee K. Funderburk

Kinesiology Faculty Publications and Presentations

Background: Resistance exercise training (RET) is a common and well-established method to induce hypertrophy and improvement in strength. Interestingly, fish oil supplementation (FOS) may aug-ment RET-induced adaptations. However, few studies have been conducted on young, healthy adults.

Methods: A randomized, placebo-controlled design was used to determine the effect of FOS, a concentrated source of eicosapen-taenoic acid (EPA) and docosahexaenoic acid (DHA), compared to placebo (PL) on RET-induced adaptations following a 10-week RET program (3 days·week−1). Body composition was measured by dual- energy x-ray absorptiometry (LBM, fat mass [FM], percent body fat [%BF]) and strength was measured by 1-repetition maximum bar-bell …

Identification Of Oral Microbiome With Full-Length 16s Sequencing Using Nanopore Technology, Uyen Hoang

Master's Projects

Human microbiota has a key role in human development and receives considerable attention from research communities. Advances in metagenomics sequencing technologies have significantly improved the capabilities to characterize microbial species associated with human health and disease. Nanopore metagenomics sequencing makes a revolution by detailed characterization of the complex human microbiome. The Nanopore approach resembles traditional genome sequencing but also presents unprecedented challenges. This project will examine the Nanopore approach for oral human microbiome analysis focusing on the 16S rRNA gene collected from the oral cavity of healthy and Mild PKU patients. The findings of this project found that Nanopore sequencing …

Exploring The Perceptions Of Genetics, Genetics Testing, And Science In People Of African Descent, Maame-Owusua Boateng

Public Health Theses

Background: Historical injustices towards Black populations in the United States have impacted how communities interact with medicine and public health such as medical experimentations, scientific racism, medical racism, and eugenics. Black communities are underrepresented in human genomics projects compared to those that identify as white or of European ancestry. Prior research has demonstrated that Black people are less likely to know about the availability of genetic testing for diseases and have less confidence in the benefits of genetic testing. These disparities make it imperative to understand the perspectives of people of African descent. Methods: The Black Genome Project is an …

A Systematic Review Of The Effect Of Maternal Circadian Disruption During Pregnancy On Adverse Fetal Outcomes, Siyu Jiang

Public Health Theses

Exposure to a suboptimal pregnant environment can raise the risk of offspring experiencing a variety of diseases in later life. Circadian rhythms play an important role in endocrine system, physiological and psychological functions. Potentially, interruption of the circadian rhythm in pregnant women might impair fetal growth and lead to adverse effects on the children. In the modern world, millions of women experience circadian disruption during pregnancy due to night shift work, excessive light at night, and jet travel across time zones. However, the impact of maternal chrono-disruption during pregnancy on the health of the second generation remains largely unknown. The …

Association Between Objectively-Measured Sedentary Time And Self-Reported Prescription Medication Use Among Adults: A Pilot Study, Ciarra Ashley Boyne

UNF Graduate Theses and Dissertations

BACKGROUND: Prescription medication use and extended sedentary time are independently related to poor health outcomes (e.g., diabetes, metabolic syndrome, mortality). Historically, survey methods have been used to obtain estimates of total sedentary time (ST), however, recent use of accelerometers avoids self-report bias and affords more characteristics of ST that may be factors in health outcomes (e.g., frequency and duration of sedentary bouts). The aims of this pilot study were to 1) examine the association between objectively measured ST via accelerometers and self-reported prescription medication use in adults and 2) examine the independent association of sedentary bout length and frequency with …

The Influence Of A Low Glycemic Load Diet On Appetite In Women With Pcos, Sarah Et Hoover

All ETDs from UAB

Dysregulated appetite may contribute to weight gain and high prevalence of comorbid obesity in women with polycystic ovary syndrome (PCOS), yet dietary recommendations to promote satiety and facilitate weight maintenance in this population remain scarce. The objective of this dissertation was to determine if women with PCOS have alterations in appetite-regulating hormones that can be manipulated by low glycemic load diet habituation to improve satiety. This was tested by secondary analyses of two randomized controlled dietary intervention trials in women with and without PCOS. First, we explored differences in women with and without PCOS during a standardized liquid meal test …

Biom 3110(Honors): Medical Physiology (Syllabus), Bradford D. Pendley

Biomedical Engineering Syllabi Archive

Course Description: Basic principles of human physiology and how these are applied in medicine and biomedical engineering problem and devices; physiological principles using appropriate mathematical and engineering models to construct an understanding of how the body works as an integrated system.

Reflections On A Career Unplanned, Robert A. Glazer

Gulf and Caribbean Research

Sometimes life takes unexpected turns. I never planned to be a marine biologist; yet, after a long and unpredictable journey, that’s exactly where I found myself. After obtaining my B.S. in Fishery Biology from Colorado State University, I found myself meandering from job to job like a golden retriever following some vague scent. At first, I was hired by the Wyoming Game and Fish Department to work seasonally in Grand Teton National Park on the freshwater trout fisheries. Soon thereafter, I found myself cultivating oysters, clams, and other shellfish in California. The skills I developed there as an algologist led …

Investigating The Electrostatics Of Mucins As Key Contributors To Mucus Stasis In Cystic Fibrosis, Elex Skylar Rose

All ETDs from UAB

Cystic fibrosis (CF) is a genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which encodes a channel responsible for the transport of chloride and bicarbonate ions across the apical cell surface. In the respiratory tract, defective CFTR results in viscous and adherent mucus that becomes static within the airway, which leads to chronic infections, progressive lung damage, and early mortality. Historically, CF mucus stasis has been attributed to significant airway dehydration; however, growing evidence has demonstrated that aberrant electrostatic properties of mucins also contribute to mucus stasis in CF. Mucins are large, polymeric glycoproteins …

Lived Experiences Of Job-Hopping Millennials During The Covid-19 Pandemic, Dottie Dancy

Walden Dissertations and Doctoral Studies

Millennials, also known as “the job-hopping generation,” are on the brink of becoming the largest generation in the workforce by 2025. In March 2020, a global pandemic was declared due to the spread of the virus known as COVID-19, which led to more than 5.3 million deaths globally. Prior research has been conducted concerning the job-hopping tendencies of Millennials, but previous studies have not incorporated the life-changing event of the global pandemic and how it may have changed the beliefs and attitudes of the Millennial generation. The purpose of this qualitative study was to explore the voluntary job-hopping beliefs and …

Adult Learners With Learning Disabilities’ Motivation To Succeed In Higher Education Online Learning During Covid19, Sara Michelle Rodriguez

Walden Dissertations and Doctoral Studies

Many students had to transition to online learning due to the COVID-19 pandemic while other students were already enrolled in online education. Online study may hold additional struggles for students with learning disabilities. The problem addressed in this qualitative, phenomenological study was the motivating factors of online higher education students who have a learning disability during the COVID-19 pandemic. The theoretical foundation was Maslow’s hierarchy of needs. Data were gathered through 10 semistructured interviews and then analyzed through the thematic analysis yielding five themes: (a) lack of professional support, (b) resources, (c) support system, (d) consistent motivation, and (e) low …

An Evaluation Of A School-Based School Connectedness Program, John G. Emmerich

Walden Dissertations and Doctoral Studies

In the United States, approximately 45% of high school students are either not engaged (28%) or actively disengaged (17%) in the academic process. Increasing a school's average student engagement yields an increase in reading and math achievement. This study evaluates a school connectedness program, Promoting Positive School Engagement (PPSE) program using a convergent mixed methods model to determine the degree of effectiveness measured by the Hemingway measure of adolescent connectedness instrument in an Urban, Midwest public middle school. Quantitative data were collected from 20 students who participated in the program and 20 students who did not (control group). Analyzed using …

Influence Of Female Sex Hormones On Ghb Toxicokinetics And Regulation Of Mcts And Smcts, Hao Wei

University of the Pacific Theses and Dissertations

Gamma-hydroxybutyric acid (GHB) is an endogenous shorty chain fatty acid that is used clinically as Xyrem to treat narcolepsy. GHB is best known for its illicit use and abuse due to its sedative/hypnotic and euphoric effects. It is used in body building, for recreational use and sexual assault. Nonlinear toxicokinetics of GHB has been described in humans and rats with decreased total clearance at higher doses due to capacity-limited metabolism resulting in a higher plasma exposure. Renal clearance increases with increasing dose and becomes the major route of GHB elimination in overdose cases due to saturation of GHB metabolism. Proton- …