Digital Commons Network^™

Mary's Conception Of The Word, Valerie M. Uhlig

Theology Graduate Theses

No abstract provided.

Central Washington University 2023-2024 Graduate Catalog, Central Washington University

Course Catalogs

No abstract provided.

Project Based Experiential Learning: Design Of Blood Pressure Monitors In Bioinstrumentation, Ahmed Sayed

ASEE North Midwest Section Annual Conference 2023 Publications

Background: Design of an electronic blood pressure monitor as a project-based learning in bioinstrumentation laboratory introduces as real-world problem-solving experience that can enhance students engagement and creativity in the classroom.
Purpose: This study presents a project-based learning experience in bioinstrumentation to design and develop an analog front end of a blood pressure monitor in a lab setting. The proposed lab modules aim to help students integrate the learning from theoretical principles and apply them in a real-world application. Methods: The activity was conducted in the last 3 weeks of the course, after covering all related theoretical topics, in addition to …

We Live In The Olden Days: Reflections On The Importance Of Scientific And Theological Humility, Steven L. Clark

Interpreter: A Journal of Latter-day Saint Faith and Scholarship

Members of The Church of Jesus Christ of Latter-day Saints have a unique perspective on truth. Our knowledge that Salvation likely involves participation in complex eternal activities requiring significantly more understanding than we currently possess naturally leads us to seek truth and, in addition, to seek an understanding of that truth. Under these circumstances, our inability to fully understand many truths, both revealed and discovered, can lead to confusion. A lack of complete understanding of accepted scientific truth generally leads the serious truth-seeker to enhanced investigative and educational efforts without doubting the ultimate veracity of the concept under investigation; we …

Post-Translational Modification Of Proteins Via Ambient Air Pollutants And Endogenous Reactive Species, Rachel Lauren Davey

Electronic Theses and Dissertations

Proteins can react with reactive oxygen species (ROS) and reactive nitrogen species (RNS) to form post-translational modifications (PTMs), which can affect protein structure and function. The formation of 3-nitrotyrosine (NTyr) and dityrosine (DiTyr) upon reaction of proteins with ROS/RNS are two common PTMs studied due to their stability and irreversibility, as well as their ability to enhance the allergenicity of pollen allergens upon formation. Many common techniques used to study the formation of these PTMs can reliably detect the PTMs but can only provide semi-quantitative information due to many assumptions and limitations. In Chapter 2 we present an analysis of …

Glutathione And Glutaredoxin—Key Players In Cellular Redox Homeostasis And Signaling, Yuh-Cherng Chai, John J. Mieyal

2023 Faculty Bibliography

This Special Issue of Antioxidants on Glutathione (GSH) and Glutaredoxin (Grx) was designed to collect review articles and original research studies focused on advancing the current understanding of the roles of the GSH/Grx system in cellular homeostasis and disease processes. The tripeptide glutathione (GSH) is the most abundant non-enzymatic antioxidant/nucleophilic molecule in cells. In addition to various metabolic reactions involving GSH and its oxidized counterpart GSSG, oxidative post-translational modification (PTM) of proteins has been a focal point of keen interest in the redox field over the last few decades. In particular, the S-glutathionylation of proteins (protein-SSG formation), i.e., mixed disulfides …

Comparison Of Clinical Study Results Reported In Medrxiv Preprints Vs Peer-Reviewed Journal Articles, Guneet Singh Janda

Yale Medicine Thesis Digital Library

The aim of this project was to evaluate the concordance among study characteristics, results, and interpretations described in preprints of clinical studies that are subsequently published in peer-reviewed journals (preprint-journal article pairs).

In this cross-sectional analysis, preprints posted on medRxiv in September 2020 were identified. Four evaluators determined how many preprints were subsequently published in peer-reviewed journals as of September 2022, calculating the time from preprint posting to publication. For preprints with multiple versions, the most recent version prior to journal acceptance was selected. Preprints updated after journal acceptance were excluded. For preprint-journal article pairs describing clinical trials, observational studies, …

Ensuring Healthy And Informed Youth: Advocating For Comprehensive Sexual Education In New York State K-12 Public Schools, Joanna Claire Vines

Renée Crown University Honors Thesis Projects - All

No abstract provided.

Wellbeing In Human-Dog Dyads: An Analysis Of Attachment And Communication, Katherine Abbott

Theses & ETDs

People love their dogs, and past studies have clearly shown that dogs are attached to their caregivers (Palmer, 2008; Schöberl et al., 2016; Topál et al.;1998; 2005). However previous studies have also indicated that people are often poor at recognizing their dog’s body language cues (Demiurbas et al., 2016; Tami & Gallagher, 2009), thereby potentially negatively affecting their relationships with their dogs. Here we investigated the relationship of dog/human dyads by analyzing each dog’s attachment to their caretaker, and each caretaker’s ability to read their dog’s body language. To measure each dog’s attachment to their caregiver, dog/human dyads engaged in …

Experiences Of Black Women In The Workforce, Neferiatiti Lukina Holt

Walden Dissertations and Doctoral Studies

Black women in America face double discrimination in the workforce. The problem is that Black women experience discrimination in the workforce based on gender and race. The purpose of this qualitative descriptive phenomenological study was to explore Black women’s experiences of discrimination in the workforce based on gender and race. The conceptual frameworks that grounded this study were general systems theory and intersectionality theory. Purposive sampling was used to identify participants; data were collected through semi-structured interviews with 13 Black women who work in a large city in central Texas. Thematic analysis based on descriptive phenomenology was applied to reveal …

Designing And Reflecting On Active Learning And Flipped Classrooms For Renal Physiology, Bernard Thomas Drumm Dr

International Journal for the Scholarship of Teaching & Learning

In this paper, we outline a case study describing the incorporation of active learning and flipped classroom techniques in a renal physiology module in 1st year medical school. The module was redesigned over a 2-year period within the teaching for understanding (TfU) framework (generative topics, understanding goals, performances of understanding and ongoing assessment) to include more active learning exercises (clicker response systems centered on clinically relevant problem sets and classroom assessment techniques – CATs), which culminated in flipping the classroom entirely during the 2nd year. The goal, was to evaluate student perceptions of the flipped classroom model and to reflect …

Lived Experiences Of Job-Hopping Millennials During The Covid-19 Pandemic, Dottie Dancy

Walden Dissertations and Doctoral Studies

Millennials, also known as “the job-hopping generation,” are on the brink of becoming the largest generation in the workforce by 2025. In March 2020, a global pandemic was declared due to the spread of the virus known as COVID-19, which led to more than 5.3 million deaths globally. Prior research has been conducted concerning the job-hopping tendencies of Millennials, but previous studies have not incorporated the life-changing event of the global pandemic and how it may have changed the beliefs and attitudes of the Millennial generation. The purpose of this qualitative study was to explore the voluntary job-hopping beliefs and …

Role Of Vitamin D, Folate, And Cobalamin Deficiency In Mycobacterium Avium Paratuberculosis Infection And Inflammation, Joseph Vaccaro

Electronic Theses and Dissertations, 2020-2023

Vitamin D, folate, and cobalamin (vitamin B12) are crucial micronutrients in human physiology that are necessary for healthy calcium, phosphorus, and single-carbon metabolism. Recent studies have indicated that these vitamins also affect the inflammatory response in ways unrelated to their well-characterized deficiencies. Accordingly, analysis of their effect on chronic inflammatory diseases like Crohn's disease (CD) is warranted. This investigation examines the effects of vitamin deficiency on macrophages and intestinal epithelial cells upon exposure to Mycobacterium avium paratuberculosis (MAP,) a pathogen capable of triggering CD, to model the inflammatory response in clinical CD patients. ELISA analysis of CD patient plasma established …

Better Science, Fewer Animals: Catalyzing Nih Grant Making To Improve Biomedical Research And Meet Societal Goals, Mikalah Singer, Paul Locke

Animal Law Review

Animal models are currently the “gold standard” in biomedical research. However, new approaches that do not involve the use of nonhuman animals are evolving to address the public health and medical challenges for which animal models are less well suited. These alternatives represent important advancements and are being recognized as significant advances. There is a clear societal need to encourage such efforts, and there is widespread support to move away from animal-based research by the American public. The National Institutes of Health (NIH) funds the majority of biomedical research in the United States and should be a key player in …

Investigating Smooth Muscle Myosin Dynamics And Assembly In Physiology And Pathology, Maggie Bennett

Dissertations

Vascular smooth muscle cells (SMCs) surround many blood vessels throughout the body,where they dynamically alter vessel diameter to regulate blood pressure, provide structural integrity, and absorb shock on a beat-to-beat timescale. As smooth muscle function fails, profound vascular disease ensues, often with tragic results- even death. Smooth muscle myosin 2 (SM2) is the dominant motor protein that actuates contractility and allows SMCs to perform these vital functions. To function, SM2 monomers dynamically assemble into filaments, which upon SMC activation, associate with filamentous actin to drive contractility. Despite the critical contribution of SM2 to SMC function, foundational aspects of SM2 assembly …

The Relationship Between Ventilation Rates In Schools And The Indoor Airborne Transmission Potential Of Covid-19, Seamus Harrington, Mark Mulville, Spyros Stravoravdis

Articles

The requirement for natural ventilation strategies in classrooms to perform in respect to both their inherent and adaptive capacity is necessary to mitigate the risk of transmission associated with infectious airborne pathogens such as COVID-19. This paper assesses the performance of ten classrooms considering (a) the designed versus actual ventilation capacity; (b) the probability of airborne disease transmission by unit time resulting from calculated ventilation rates and (c) the reduction of transmission risk associated with mask wearing by all occupants.

Monitored air changes per hour (ACH) range from 0.26–1.7, demonstrating that none of the classrooms meet designed ventilation rate whilst …

Biom 3110: Medical Physiology (Syllabus), Bradford D. Pendley

Biomedical Engineering Syllabi Archive

Course Description: Basic principles of human physiology and how these are applied in medicine and biomedical engineering problem and devices; physiological principles using appropriate mathematical and engineering models to construct an understanding of how the body works as an integrated system.

Introduction To Psychology, Gail Hayes

Open Educational Resources

Introduction to Psychology is a modified version of Psychology 2e - OpenStax.

The More Severe Adverse Effect Of Alcohol In Fc Gamma Receptor Iib Deficient (Fcgrllb-/-) Lupus Mice Than In Wild-Type Due To The More Profound Responses Against Alcohol-Induced Leaky Gut, Phatcharapon Yiengwattananon

Chulalongkorn University Theses and Dissertations (Chula ETD)

Consuming alcoholic beverages is well-known to have a part in causing inflammation and obstructing the function of the digestive system, and it may lead to leaky intestines. However, the relationship between alcohol consumption and Systemic Lupus Erythematosus (SLE) remains a subject of controversy continued. In general, alcohol can promote intestinal bacterial dysbiosis and also result in endotoxin release by Gram-negative bacteria. This stimulates many immune cells to produce inflammatory cytokines in the gut. This study focuses on the inflammatory response effect of FcgRIIb-/- mice upon loss of FcgRIIb receptors in which alcohol-induced leaky gut can occur. In 8-week-old mice lacking …

Anatomy Certification Annual Program Outcomes Assessments, 2022-23, College Of Science And Mathematics, Wright State University

Annual Program Outcomes Assessments - All

This report reviews Wright State University's Anatomy Certification Degree program for the 2022-2023 academic year.

Anatomy Masters Degree Annual Program Outcomes Assessments, 2022-23, College Of Science And Mathematics, Wright State University

Annual Program Outcomes Assessments - All

This report reviews Wright State University's Anatomy Master's Degree program for the 2022-2023 academic year.

Physiology And Neuroscience Master's Degree Annual Program Outcomes Assessments, 2022-23, College Of Science And Mathematics, Wright State University

Annual Program Outcomes Assessments - All

This report reviews Wright State University's Physiology and Neuroscience Master's Degree program for the 2022-2023 academic year.

“The Gospel Of Intelligence And Culture”: Literature And Literary Instruction In The Twentieth-Century Mia Curriculum, Michael Austin, Rachel Meibos Helps

BYU Studies

In his journal for April 29, 1888, Bishop Orson F. Whitney recorded a curious meeting that he had with an Apostle. “Had a long conversation in the morning with Apostle Moses Thatcher,” wrote Whitney. “He gave me a blessing and set me apart to deliver a lecture on Sunday, June 3rd next, at the Mutual Improvement Conference in the Tabernacle. My subject is Home Literature. I consented to deliver it, though very busy and overworked, at the request of the Authorities.” This remarkable assignment— he was called and set apart to give a speech in the way men at the …

Immune System Dysfunction To Toxicant Exposure: An Examination Of Mismatch Theory With Polychlorinated Biphenyls (Pcbs) And Dichlorodiphenyltrichloroethane (P,P'-Ddt), Florence Lee

Legacy Theses & Dissertations (2009 - 2024)

Exposure to environmental contaminants, including persistent organic pollutants (POPs) can disrupt normal immune function. As POPs, polychlorinated biphenyls (PCBs), dichlorodiphenyldichloroethane (p,p’-DDE, a metabolite of p,p’-DDT), and hexachlorobenzene (HCB) are synthetic chemicals with long half-lives and can bioaccumulate and biomagnify within organisms throughout the food chain. This dissertation proposes that pollutant exposure can affect the immune system based on a sample of Native American women, thereby influencing human biological variation, and the development of an autoimmune phenotype. Data was collected from a sample of Native American women utilizing anthropometric measurements, medical diagnoses of autoimmune disease, autoimmune dysfunction symptoms, and serum samples. …

Investigating The Physiological Use Of An Organ-On-A-Chip Device Through The Design And Fabrication Of A Micro-Electrical Blood-Brain Barrier (Μe-Bbb) System, Amrita Srinivasan, Kiana Aran, Jonalyn Herce, Noor Chaudhry, Allexa Ortiz

CMC Senior Theses

Aging is considered the main risk factor for various neurodegenerative disorders including Alzheimer’s disease (AD) and Parkinson’s disease (PD). Aging is associated with an increase in neuroinflammation, which is a significant contributor to cognitive impairment observed in these age-related neurodegenerative diseases. However, studying brain behavior remains a challenge due to the complex nature of isolating brain tissue from an organism. Modeling the brain allows for further study of these neurodegenerative diseases. Organ-on-a- chip (OoC), a system containing engineered or natural tissues grown within microfluidic chips, has emerged as a promising tool for mimicking human physiology in a controlled microenvironment. A …

To Limit Air Pollution's Risks: A Law/Science Success Story, Jamison E. Colburn

Faculty Scholarship

This is the first major study of the National Ambient Air Quality Standards (NAAQS) in a generation. This study focuses on a unique co-evolution of science and law over more than a half-century of development. Our NAAQSs can be found everywhere from your phone’s air quality index to the trends of cardiovascular and respiratory disease in America. Yet no one has studied the ways in which law and the science of air pollution have reciprocally determined each other through them. Through a study of 26 reviews across seven presidencies and 21 reported opinions adjudicating 106 petitions challenging those reviews/revisions, this …

School Of Health And Consumer Sciences Free Communication Day: Research Abstracts, Spring 2023., Mary Beth Zwart, Elizabeth Droke, Seth Daughters

Health and Nutritional Sciences Graduate Students Plan B Capstone Projects

This document contains Plan B abstracts presented by graduate students at the School of Health and Nutritional Sciences Free Communication Day: Research Dissemination held on May 2nd, 2022.

Catalog Revision Gen Ed, Academic Affairs

Executive Actions

No abstract provided.

General Education Catalogue Revisions, Academic Affairs

Program Revisions/Additions

No abstract provided.

An Examination Of The Food System, Foodscape, Dietary Patterns, And Accolated Health Outcomes Of Salish People Within The Confederated Salish And Kootenai Nation, Joshua William Brown

Graduate Student Theses, Dissertations, & Professional Papers

Often an individualistic, consumerist strategy is promoted as the solution to decrease the growing prevalence of diet-related diseases. Unfortunately, this logic is ahistorical and apolitical while privileging pathological individualism, capitalistic consumerism, and prevalent diets within the United States. This reasoning fails to recognize diet construction across time by ideologies, policies, and practices. Such an outlook misses the reality that many people cannot escape the grip of the modern, pervasive, ultra-processed food system.

Several Native American populations find themselves plagued with high rates of diet-related diseases. Standard mantra shoulders these communities with their plight, often framing the discourse as personal responsibility …