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Evidence-Based Guidelines For Prevention Of Inadvertent Hypothermia In Total Joint Arthroplasty, Courtney Morris

Doctor of Nursing Practice Scholarly Projects

Hypothermia is a core body temperature below 36 degrees Celsius. Hypothermia is a common occurrence for many surgical patients that presents with many complications. When patients experience hypothermia during the perioperative setting, it is defined as Inadvertent Perioperative Hypothermia (IPH). During surgery, the patient typically has large body areas exposed to perform surgery in a room that is kept cool leading to lower body temperature and under general anesthesia the body’s ability to regulate body temperature is impaired. Patients who are undergoing total joint arthroplasties (TJA), a hip or knee replacement, are a high-risk population for IPH, therefore, increasing their …

Blood Pressure Surge With Alarm Is Reduced After Exercise And Diet Intervention In Firefighters, Deborah L Feairheller, Macie Smith, Megan Carty, Emily H Reeve

College of Population Health Faculty Papers

BACKGROUND: Cardiac-related incidents are a public health concern for tactical occupations, and cardiovascular disease rates are higher in these populations compared with civilians. Research is needed to examine blood pressure (BP) responses in firefighters. The pager alert is one occupational hazard, and it is unknown if lifestyle change can reduce the systolic surge response.

PURPOSE: To measure BP surge with alarm in firefighters to determine whether the magnitude is lower after a 6-week tactical exercise and Mediterranean-diet intervention.

METHODS: SBP and DBP and BP surge levels, circulating markers, vascular health, and fitness were analyzed. BP surge with alarm was captured …

Electrodermal Activity In Response To Stress Reduction: Virtual Reality Experience In Hydrotherapy And Non-Hydrotherapy Environments, Nthabeleng Macdonald

Undergraduate University Honors Capstones

Hydrotherapy, a holistic alternative medicine, uses methods like water therapy, cold water immersion, and balneotherapy to treat physical and mental illnesses while inducing tranquility (Bahadorfar, 2014). In this study, the water therapy approach was used, but with a unique twist. Rather than traditional hydrotherapy involving direct contact with water, participants were fully immersed in a virtual reality water environment. This study investigated whether immersing individuals with psychological stress in an underwater environment via virtual reality (VR) reduces their stress levels as compared to a non-hydrotherapy virtual city environment. The effects of underwater scenery versus non-hydrotherapy city scenery individuals experiencing stress …

Editorial To The Ijms Special Issue On Sglt2 Inhibitors Vol. 1, Anastasios Lymperopoulos

HPD Articles

No abstract provided.

Comparing Student Satisfaction In High- And Low-Fidelity Simulation Experiences, Bailey Kuhlman

Doctor of Nursing Practice Scholarly Project

The purpose of this project was to compare student satisfaction in high- and low-fidelity simulation experiences. The project took place at the Pittsburg State University Irene Ransom Bradley School of Nursing. Participants included 79 pre-licensure Fundamentals of Nursing students in their first semester of nursing school. Implementation took place in the Fall of 2022. Students underwent either a high- or low-fidelity patient simulation experience related to pneumonia. Upon completion of the scenario students were asked to voluntarily participate in a satisfaction questionnaire. The questionnaire was composed of 27 closed-ended questions. There was a statistically significant difference with higher satisfaction scores …

A Comparison Of The Vascular Response To Acute Sauna Heating In Young And Middle-Aged Adults, Olivia Kathryn Leach

Theses and Dissertations

BACKGROUND: Age-related declines in endothelial function have been well documented with larger declines observed in middle-aged. Passive heat exposure has been shown to be a promising method to improve vascular endothelial health, with sauna specifically being linked to reduced risk of cardiovascular disease. Increases in blood flow and shear rates associated with heat exposure are often considered to have a major influence on the observed improved endothelial function following heat exposure. The magnitude of these changes in response to sauna have not yet been defined. Therefore, the purpose of this study is to quantify and compare the vascular response to …

Newsroom, Georgia Southern University

Newsroom (2006-2023)

A Gut Feeling: Georgia Southern Researchers Exploring How the Gut Microbiome Adapts and Shifts in Endurance Athletes

Astrovirology: How Viruses Enhance Our Understanding Of Life In The Universe, Gareth Trubl, Ken Stedman, Kathryn F. Bywaters, Emily E. Matula, Pacifica Sommers, Simon Roux, Nancy Merino, Multiple Additional Authors

Biology Faculty Publications and Presentations

Viruses are the most numerically abundant biological entities on Earth. As ubiquitous replicators of molecular information and agents of community change, viruses have potent effects on the life on Earth, and may play a critical role in human spaceflight, for life-detection missions to other planetary bodies and planetary protection. However, major knowledge gaps constrain our understanding of the Earth’s virosphere: (1) the role viruses play in biogeochemical cycles, (2) the origin(s) of viruses and (3) the involvement of viruses in the evolution, distribution and persistence of life. As viruses are the only replicators that span all known types of nucleic …

The Echo: April 3, 2023, Taylor University

2022-2023 (Volume 110)

No abstract provided.

The Association Between Caffeine Intake And The Colonic Mucosa-Associated Gut Microbiota In Humans-A Preliminary Investigation, Annie Dai, Kristi Hoffman, Anthony A Xu, Shawn Gurwara, Donna L White, Fasiha Kanwal, Albert Jang, Hashem B El-Serag, Joseph F Petrosino, Li Jiao

Faculty, Staff and Students Publications

We examined the association between caffeine and coffee intake and the community composition and structure of colonic microbiota. A total of 34 polyp-free adults donated 97 colonic biopsies. Microbial DNA was sequenced for the 16S rRNA gene V4 region. The amplicon sequence variant was assigned using DADA2 and SILVA. Food consumption was ascertained using a food frequency questionnaire. We compared the relative abundance of taxonomies by low (<82.9 mg) vs. high (≥82.9 mg) caffeine intake and by never or <2 cups vs. 2 cups vs. ≥3 cups coffee intake. False discovery rate-adjusted p values (q values) <0.05 indicated statistical significance. Multivariable negative binomial regression models were used to estimate the incidence rate ratio and its 95% confidence interval of having a non-zero count of certain bacteria by intake level. Higher caffeine and coffee intake was related to higher alpha diversity (Shannon index p < 0.001), higher relative abundance of Faecalibacterium and Alistipes, and lower relative abundance of Erysipelatoclostridium (q values < 0.05). After adjustment of vitamin B2 in multivariate analysis, the significant inverse association between Erysipelatoclostridium count and caffeine intake remained statistically significant. Our preliminary study could not …

Environmental Exposures From The Local To The Global: A Comparison Of The Experiences And Consequences Of Exposure Among The Qom Of Formosa, Argentina, And Residents Of New Haven, Connecticut, Carlye Chaney

Yale Graduate School of Arts and Sciences Dissertations

Exposure to endocrine disrupting chemicals and other environmental contaminants is globally ubiquitous and can have adverse consequences on health throughout the lifespan. In this project, I investigated the experiences and consequences of environmental contaminant exposure for maternal and infant health in two places that differ environmentally, politically, and socioeconomically –Namqom in Formosa, Argentina, and New Haven, Connecticut. Specifically, I hypothesized that environmental contaminant exposure influences human well-being and physiology, as assessed from the human milk and urine metabolome, through changes in the hypothalamic-pituitary-gonadal (HPG) axis in both infancy and adulthood.I first investigated the local context, both historical and present, that …

Molecular Mechanisms Of Microbial Adaptation To The Host, Daniel G. Dumitrescu

Yale Graduate School of Arts and Sciences Dissertations

All host-associated microorganisms require mechanisms to adapt to stress encountered in the host. In particular, host immunity generates reactive oxygen species (ROS) as a measure to regulate microbial expansion in the gut and to kill invading pathogens. ROS are broadly toxic to cellular biomolecules, and consequently both microorganisms and the host employ molecular mechanisms to contend with their harmful properties. Accordingly, all life forms rely on low- molecular-weight (LMW) thiols, a family of ubiquitous small molecule antioxidants, to maintain intracellular redox homeostasis and resist oxidative damage caused by ROS. Chapter 1 reviews the molecular and biological functions of LMW thiols, …

Cerebrospinal Fluid Protein Markers Indicate Neuro-Damage In Sars-Cov-2-Infected Nonhuman Primates, Sudipa Maity, Meredith G. Mayer, Qingbo Shu, Hellmers Linh, Duran Bao, Robert V. Blair, Yanlin He, Christopher J. Lyon, Tony Y. Hu, Tracy Fischer, Jia Fan

Division of Basic Science Faculty Publications

Neurologic manifestations are among the most frequently reported complications of COVID-19. However, given the paucity of tissue samples and the highly infectious nature of the etiologic agent of COVID-19, we have limited information to understand the neuropathogenesis of COVID-19. Therefore, to better understand the impact of COVID-19 on the brain, we used mass-spectrometry–based proteomics with a data-independent acquisition mode to investigate cerebrospinal fluid (CSF) proteins collected from two different nonhuman primates, Rhesus Macaque and African Green Monkeys, for the neurologic effects of the infection. These monkeys exhibited minimal to mild pulmonary pathology but moderate to severe central nervous system (CNS) …

Firefighter: 24/48 Versus 48/96; Sleep, Strain, And Recovery, Amy Sprague

Honors Theses

Firefighters provide important safety services for a 24-hour society. Sleep is very important to the human body. Without sleep a person can experience both short- and long-term side effects. These side effects not only put the sleep deprived person in danger but can also put the public in danger as well. There are many different shift schedules that fire departments can run on. While on duty firefighters must be ready to respond to any emergency call, they receive no matter the time. This can impact the amount of sleep they get while on duty. The current study used biometric straps …

Untethering Umvs From Vessels: Why The United States Should Construct A New Environmental Legal Scheme For Unmanned Maritime Vehicles, Lindsay I. Mccarl

Dickinson Law Review (2017-Present)

International and domestic laws and regulations, and in particular those addressing environmental protections related to the world’s oceans, have no clear application to unmanned maritime vehicles (UMVs). Instead, legal scholars have attempted to fit UMVs into current legal schemes in a piecemeal manner that UMVs practically and realistically cannot comply with. UMVs are inherently different than their manned counterparts and therefore require a unique legal framework separate and apart from manned vessels. Without its own legal scheme, the United States Navy and other organizations will not be able to realize the full potential of UMVs—not only for their military operational …

Impact Of A Multi-Month Ultra-Endurance Backpacking Trek On Measures Of Physiological & Psychological Recovery & Readiness: A Case Study, E. Flacke, E. Glick, A. Rainey, H. Scharf, T. Gardner, A. Ragusa, A. M. Stranieri, K. S. Levers

GW Research Showcase 2021-2026

No abstract provided.

Small Unmanned Aircraft Systems: Operator Workload And Situation Awareness Utilizing First Person View Techniques, Ross Lucas Stephenson Jr

Doctoral Dissertations and Master's Theses

The small, unmanned aircraft systems (sUAS) sector within the aviation industry is experiencing unprecedented growth. However, the regulatory guidance for the safe integration of sUAS into the National Airspace System (NAS) has not kept pace with this technological growth within the market. Current regulatory limitations of line-of-sight operations may have an impact on the establishment of an equivalent level of safety for sUAS operations as maintained by manned aircraft. The focal point of the discussion of line-of-sight operations has been the ability of the sUAS pilot to see and avoid all obstacles and other aircraft in a safe and timely …

Predictability Augmentation By In-Silico Study To In-Vivo And In-Vitro Results Of Lung Doses Of Airborne Fine And Ultrafine Particles Inhaled By Humans At Industrial Workplaces, Mohammed Ali

Technology Faculty Publications and Presentations

This study correlates computational predictions with in vivo and in vitro experimental results of inhaled fine and ultrafine particulate matter (PM) transport, dissemination, and deposition in the human respiratory airways. Epidemiological studies suggest that workplace exposure to anthropogenic pollutant PMs is a risk factor for increased susceptibility to acute bronchopulmonary illnesses. However, investigations on detailed human inhalation and PM transport processes are restrictive from time, cost, and ethical perspectives. Computational simulation based on the Multiple Path Particle Dosimetry (MPPD) model was employed to quantify the risks associated with workplace exposure of these PMs. Here, the physical, mechanical, and electrical properties …

Introduction To Human Biology, Sharon S. Ellerton, Christopher Roblodowski

Open Educational Resources

This OER is intended as a textbook for a one semester introductory course in Human Anatomy and Physiology for non-science majors. It covers the major topics typically covered in A&P, but in a simplified, easier to understand manner. This textbook aims to educate students interested in lower-level health careers and non-science majors without the intimidating detail found in current textbooks. Text and images were created to be more accessible for these student populations.

Health Consequences Of Low Energy Availability In Females And Their Underlying Physiological Mechanisms, Grace Parry

Senior Honors Theses

Low energy availability (LEA) is a state in which energy intake is insufficient to support energy expenditure while maintaining energy balance, which has been shown to result in gastrointestinal distress, immunosuppression, reduced metabolic rate, menstrual dysfunction, diminished bone health, and impaired cardiovascular function in females. Alterations to the microbiome and mucosal lining may propagate gastrointestinal complaints and compromised immune function associated with LEA. The pathophysiology of LEA is otherwise largely driven by hormonal adaptations. Diminished production of thyroid hormones is known to contribute to reduced metabolic rate. Decreases in leptin and insulin and increases in ghrelin disrupt reproductive function through …

Flexible Materials And Applications For Wearable Sensors, Brock Ferrari

Senior Honors Theses

This literature review aimed to address the limitations of rigid wearable sensors in the medical community by investigating the development of flexible materials for remote health monitoring. A keyword search was conducted on Google Scholar, PubMed, and the Jerry Falwell Library, which yielded 9,102 articles. After applying filtering techniques, the results were narrowed down to 21 articles, which were categorized into "Present Market Conditions," "Flexible Materials for Medical Use," "Applications for Wearable Sensors," and "Potential Use Cases." Discussions were held on prominent materials such as substrate, nanocomposite, and liquid metal materials, exploring their potential applications for chemical and physical sensing, …

Volume Change Measurements Of Cancer Cells In A Microfluidics Platform, Yukuan Yu

Theses and Dissertations

Understanding the function of aquaporins in transcellular transport is vital for homeostasis, pathophysiology, and translational potential in AQP-based diagnostics and therapeutics. Microfluidics device has the potential to evaluate the function of aquaporins with precise control and manipulate micro-scale fluid due to good optical quality and short processing distance. This work has two parts: cell culture in a microfluidic chip to characterize aquaporins’ function and visualization of single cell volume change under osmotic pressure shock in a homemade imaging dish. For the first part, we established a microfluidics platform for future modification and measurement of the dynamic volume change of biological …

Small Demos, Big Impacts When Teaching Exercise Physiology, Erin White

Educational Practices in Kinesiology

Comprehension of exercise physiology topics as an undergraduate student can be difficult. Thus, finding creative ways to present material can improve student comprehension and retention. The purpose of the three demonstrations presented will teach three concepts to lower-division students in an undergraduate Exercise Physiology course (prerequisite knowledge in college-level Human Anatomy and Human Physiology courses). These demonstrations take place in-person, in the classroom, with an estimated total time commitment of approximately10 minutes. The purpose of demonstrations 1 and 2 will aid students in differentiating between Golgi Tendon Organs (Demonstration 1) and muscle spindles (Demonstration 2), including their location and protective …

Simulating Human Senses To Improve Thermal Comfort, Ahmed Marey, Nihal Alsabbagh

Architecture and Planning Journal (APJ)

Between the synergies of environmental perception and technological advancement evolves the parallel world of the metaverse. Evolutionary virtuality intends to aid humanity in envisioning the threatened future of cities under environmental risks through tailored features. Traditionally, the sense of sight – which is the focus of virtual reality – has dominated the architectural practice. However, architects and urban designers have begun incorporating other senses into their work over the recent decade. The expanding understanding of the multimodal nature of the human mind that has evolved from cognitive neuroscience research has received little attention so far in the architecture field. This …

Application Of The Recitation Method To Improve The Competence Of Medical Laboratory Technology Students In The Immunology Field, Patricia Gita Naully, Perdina Nursidika

Jurnal Pendidikan Sains

An accredited mid-level MLT (Medical Laboratory Technology) must have the competence to perform medical laboratory examinations from pre-analytic, analytic, and post-analytic stages in several fields, one of which is immunology. Many D3 MLT students are facing obstacles to passed the immunology course. This obstacle is not only experienced by students of D3 MLT but also by medical students, pharmacy students, and similar majors. The purpose of this research is to determine the effect of recitation method in the form of animation video making and immunology based device on the competence of Diploma 3 (D3) MLT students. This research is a …

Cardiac Rgs Proteins In Human Heart Failure And Atrial Fibrillation: Focus On Rgs4., Jordana I. Borges, Malka S. Suster, Anastasios Lymperopoulos

HPD Articles

The regulator of G protein signaling (RGS) proteins are crucial for the termination of G protein signals elicited by G protein-coupled receptors (GPCRs). This superfamily of cell membrane receptors, by far the largest and most versatile in mammals, including humans, play pivotal roles in the regulation of cardiac function and homeostasis. Perturbations in both the activation and termination of their G protein-mediated signaling underlie numerous heart pathologies, including heart failure (HF) and atrial fibrillation (AFib). Therefore, RGS proteins play important roles in the pathophysiology of these two devasting cardiac diseases, and several of them could be targeted therapeutically. Although close …

International Society Of Sports Nutrition Position Stand: Nutritional Concerns Of The Female Athlete, Stacy T. Sims, Chad M. Kerksick, Abbie E. Smith-Ryan, Xanne A.K. Janse De Jonge, Katie R. Hirsch, Shawn M. Arent, Susan Joyce Hewlings, Susan M. Kleiner, Erik Bustillo, Jaime Tartar, Valerie Starratt, Richard B. Kreider, Casey Greenwalt, Liliana I. Rentería, Michael J. Ormsbee, Trisha Vandusseldorp, Bill I. Campbell, Douglas S. Kalman, Jose Antonio

HPD Articles

Based on a comprehensive review and critical analysis of the literature regarding the nutritional concerns of female athletes, conducted by experts in the field and selected members of the International Society of Sports Nutrition (ISSN), the following conclusions represent the official Position of the Society: 1. Female athletes have unique and unpredictable hormone profiles, which influence their physiology and nutritional needs across their lifespan. To understand how perturbations in these hormones affect the individual, we recommend that female athletes of reproductive age should track their hormonal status (natural, hormone driven) against training and recovery to determine their individual patterns and …

Impact Of Intravenous Fluid Administration On Cardiac Output And Oxygenation During Cardiopulmonary Resuscitation, Jennifer Lutz, Yosef Levenbrown, Md Jobayer Hossain, Anne Hesek, Kelly E. Massa, James P. Keith, Thomas H. Shaffer

Department of Pediatrics Faculty Papers

Background: The efect of intravenous fuid (IVF) administration during cardiopulmonary resuscitation (CPR) is an unexplored factor that may improve cardiac output (CO) during CPR. The aim of this study was to determine the efect of IVF administration on CO and oxygenation during CPR.

Methods: This experimental animal study was performed in a critical care animal laboratory. Twenty-two Landrace-Yorkshire female piglets weighing 27–37 kg were anesthetized, intubated, and placed on positive pressure ventilation. Irreversible cardiac arrest was induced with bupivacaine. CPR was performed with a LUCAS 3 mechanical compression device. Pigs were randomized into IVF or no-IVF groups. Pigs in the …

Toward A Simulation Model Complexity Measure, J. Scott Thompson, Douglas D. Hodson, Michael R. Grimaila, Nicholas Hanlon, Richard Dill

Faculty Publications

Is it possible to develop a meaningful measure for the complexity of a simulation model? Algorithmic information theory provides concepts that have been applied in other areas of research for the practical measurement of object complexity. This article offers an overview of the complexity from a variety of perspectives and provides a body of knowledge with respect to the complexity of simulation models. The key terms model detail, resolution, and scope are defined. An important concept from algorithmic information theory, Kolmogorov complexity, and an application of this concept, normalized compression distance, are used to indicate the possibility of measuring changes …

The Effects Of Acute Hypoxia On Cognitive And Cardiovascular Parameters In Healthy Subjects, R Ravi, Mmf Subhan

School of Biomedical Sciences

Background: Hypoxia can affect the health and safety of patients and persons in various occupations. There is uncertainty surrounding the effect acute hypoxia may have on cognition and the cardiovascular system. Aims: The aim was to examine cognition using the Wechsler Abbreviated Scale of Intelligence – First Edition (WASI-I) and investigate heart rate variability (HRV) with varied fraction of inspired oxygen (FiO2) of 0.12, 0.165 and 0.21. Methods: Seventeen healthy volunteers participated in two tasks of the WASI-I; block design (BD) and matrix reasoning (MR). BD, MR and HRV were measured during randomized gas interventions. A subset had their cerebral …