Digital Commons Network^™

Towards A New Model Of Romantic Attachment For Autistic Adults, Michael Preston Huttar

Theses and Dissertations

Autism spectrum disorder is an extremely prevalent developmental disorder, which impacts social-relational functioning. The majority of past research into autism has focused on childhood early intervention and skill development. In comparison, a minute amount of research has been dedicated to the study of autistic adults, particularly within the context of romantic relationships. In this article, we explore the relationships between autistic traits, relationship quality factors (i.e. intimacy, passion, commitment, and satisfaction), and the mediating variable of relationship maintenance behaviors as a possible mechanism in explaining this relationship. Contrary to our hypothesis, autism traits were shown to have no relationship with …

The Effect Of Sterol Carrier Protein 2 Gene Ablation And Dietary Cholesterol On Brain And Liver Lipid Composition In Male And Female Mice, Madison Jochim

Theses and Dissertations

Previous studies have shown that sterol carrier protein 2 (SCP-2) and sterol carrier protein x (SCP-x) are important for mediating the transfer of phospholipids, cholesterol and other sterols within the cell. However, the differences between males and females regarding the impact SCP2 has on brain and liver lipid metabolism is unknown. To further understand this, we profiled the effects of SCP2 gene ablation on brain and liver lipid metabolism in male and female mice fed a high fat diet or control diet and analyzed phospholipid and neutral lipid mass and composition using HPLC and TLC. In brains of male mice, …

How Abortion Status Predicts Stigmatizing Beliefs: Measuring Enacted Stigma Using The Stereotype Content Model, Jenna Nichole Laurin

Theses and Dissertations

Enacted stigma consists of active discrimination or negative treatment towards an individual who has received an abortion. Further, stereotypes of individuals typically fit within perceptions of competence and warmth, however these stereotypes have not been measured about women who have received an abortion despite the fact that they can indicate stigmatizing beliefs. Additionally, enacted stigma may present differently between men and women. The purpose of the current study was to measure perceptions of competence and warmth as a form of stigma about women with and without a history of abortion, as well as women who considered an abortion but did …

Core Values In Higher Education: Students, Faculty, Staff, And Administrator Alignment At A Midwestern Research University, Rodney Deshan Lewis

Theses and Dissertations

A growing body of research exists on core values. However, limited scholarly research exists on core values in higher education institutions that operate in volatile, uncertain, complex, and ambiguous (VUCA) environments. And yet, society entrusts higher education with our nation’s most important resource—our future leaders. University adopted core values serve as guideposts for institution stakeholders. Core values are important for an organization’s identity by providing concise and powerful guidelines for collective stakeholder action. Core values provide a true north values vector, especially when ambiguity and uncertainty exist. This, in turn, helps increase judgement and decision-making skills that are clearly aligned …

Educator Perceptions On Equity And Inclusion In The Classroom, Brittany N. Melfi

Theses and Dissertations

The purpose of this research study is to identify solutions that can improve equity and inclusion measures in the educational classroom settings for all school community members. This qualitative research explores educators’ perceptions of solutions and barriers to improving equity and inclusion in education. Currently, there is limited research from this stakeholder perspective. This bottom-up research approach aims to determine the needs of those stakeholders in the immediate environment and what supports they feel are necessary to make immediate and lasting change. The qualitative research study took place in a small Pennsylvania school with an enrollment of 387 students and …

Antibiotics And Secondary Metabolites Analysis Shell (Antismash) As A Tool To Detect Putative Novel Antibiotics, Rajiv Snape

Theses

In the Hudson Lab, which is focused on discovering new antibiotics, bacteria samples are taken from the environment and cultured in large quantities. Then they are tested for antibiotic resistance before they are sequenced and their secondary metabolite compounds are extracted. This is both a lengthy and expensive process that becomes more and more difficult as the number of samples one is working increases. This project assessed a different approach to rejuvenate antibiotic development with antiSMASH. antiSMASH is an online tool created by collaborators from many different institutions that uses profile Hidden Markov Models (pHMMs) to detect gene clusters which …

Multifactor Authentication Using Zero Trust, Mathews Rajan Alappat

Theses

In today's world, industries are constantly integrating new technologies to improve workplace flexibility and customer service. However, this also creates a broader attack surface for attackers, making it easier for them to identify weaknesses and exploit them, leading to security lapses that cost businesses both money and goodwill. To address this issue, information technology security professionals have developed the Zero Trust framework. This framework focuses on carefully examining each and every attempt made to access the resources, restricting access only to those authorized individuals and providing them with minimum privileges to accomplish their specific tasks successfully. The underlying concept behind …

Identifying The Causes Of Heart Disease Using Classification Techniques, Wadeema Alshamsi

Theses

Heart disease is a global epidemic that affects millions of people and is responsible for a significant portion of annual deaths worldwide. Timely diagnosis and prediction of heart disease can save countless lives, and advancements in information technology have opened up new avenues for improving medical diagnosis. In this project, we aimed to explore the use of machine learning classification techniques for predicting the presence of heart disease in patients. We deployed five classification techniques: Logistic Regression, Decision Tree, Random Forest, K Nearest Neighbors, and Support Vector Machine. We used a dataset of 1025 observations with 13 features and one …

Energy Consumption Of Drones For Delivery Usage: Case Study In Dubai, Maitha Huraiz Bin Touq

Theses

In the past couple of years, the dependency of delivery services on road vehicles has increased, compromising the efficiency of this service in urban areas. Aside from efficiency, another issue is the increase in greenhouse emissions, which jeopardizes the government's efforts to reduce dangerous gasses. Drone-based delivery has been highlighted as one of the most promising technologies in the field of delivery systems. This system could ease traffic congestion, expediting delivery efficiency, and in parallel, the use of electrified drones could help with decarbonizing the atmosphere. This study examines the use of drones for delivery in the city of Dubai …

Analysis Of Micro-Perforated Packaging Systems For Minimally Processed Fresh Greens, Heidy Lizardo

Theses

Because of the increased demand for fresh greens presented in an accessible format, the demand for a new packaging technology to extend shelf life has also increased. Micro perforation is a packaging system that allows rapidly modifying headspace gases under refrigerated storage. Previous research has demonstrated that the pattern in which the perforations are aligned in the film affects the gas exchange modification of the package headspace gases. A rapid modification of the headspace gases of the product in the package must be achieved in order to guarantee extended shelf life. Several patterns of micro-perforation location and density have been …

Unprecedented Precedent And Original Originalism: How The Supreme Court’S Decision In Dobbs Threatens Privacy And Free Speech Rights, Leonard Niehoff

Articles

The U.S. Supreme Court’s decision in Dobbs v. Jackson Women’s Health Organization has drawn considerable attention because of its reversal of Roe v. Wade and its rejection of a woman’s constitutional right to terminate her pregnancy. The Dobbs majority, and some of the concurring opinions, emphasized that the ruling was a narrow one. Nevertheless, there are reasons to think the influence of Dobbs may extend far beyond the specific constitutional issue the case addresses.

This article explains why Dobbs could have significant and unanticipated implications for the law of privacy and the law of free expression. I argue that two …

Informationalism Beyond Managerialism, Salome Viljoen

Articles

It is now commonplace to observe that digital platforms are both affecting and reshaping markets. The focus of this Article is not the anticompetitive effects of digital platforms upon the markets they enter. It instead focuses on digital platforms themselves as market mechanisms. Information—especially datafied information about people and their behavior—and information technologies have transformed how many markets function in the digital economy. Markets have become market machines: highly engineered and computationally intensive market-like mechanisms that make up a key layer of technological infrastructure within digital platforms.

Constitutional Losses And (Some) Statutory Wins For Criminal Defendants: Select Criminal Law And Procedure Cases From The Supreme Court's 2022-2023 Term., Eve Brensike Primus, Mark Rucci

Articles

The Supreme Court’s 2022–23 Term included a number of important statutory interpretation rulings, as well as significant cases concerning the scope of the Confrontation Clause; the Venue, Vicinage, and Double Jeopardy Clauses; the federal courts’ ability to entertain claims of legal innocence; and the contours of the adequate and independent state ground doctrine. It also was the first term for Justice Ketanji Brown Jackson—the first former public defender and first Black woman to join the centuries-old institution. Although Justice Jackson joined a Court ruptured along ideological lines and confronting serious challenges to its legitimacy and ethical standards, she quickly proved …

The Great Regulatory Dodge, Helen Nissenbaum, Katherine Strandburg, Salome Viljoen

Articles

U.S. privacy law is in a renewed moment of regulatory possibility, with both Congress and the states considering sweeping consumer privacy laws. These new proposals to enact “omnibus” privacy protections could be couched as an antidote to the current U.S. privacy regime: a patchwork of sectoral privacy laws stitched atop the background of FTC consumer contract enforcement. However, this Essay maintains that a one-size-fits-all approach cannot successfully capture both privacy’s value and its variability. Yet, it is clearly the case that the present- day sectoral regime in the United States suffers from significant shortcomings. These shortcomings allow behaviors that seem …

Defining Genetic Diversity Of Rhesus Macaque Fcγ Receptors With Long-Read Rna Sequencing., Haleigh E. Conley, Max M. He, David Easterhoff, Hélène Fradin Kirshner, Sarah L. Cocklin, Jacob Meyer, Taylor Hoxie, Madison Berry, Todd Bradley, William D. Tolbert, Marzena Pazgier, Georgia D. Tomaras, Joern E. Schmitz, Michael Anthony Moody, Kevin Wiehe, Justin Pollara

Manuscripts, Articles, Book Chapters and Other Papers

Fcγ receptors (FcγRs) are membrane-bound glycoproteins that bind to the fragment crystallizable (Fc) constant regions of IgG antibodies. Interactions between IgG immune complexes and FcγRs can initiate signal transduction that mediates important components of the immune response including activation of immune cells for clearance of opsonized pathogens or infected host cells. In humans, many studies have identified associations between FcγR gene polymorphisms and risk of infection, or progression of disease, suggesting a gene-level impact on FcγR-dependent immune responses. Rhesus macaques are an important translational model for most human health interventions, yet little is known about the breadth of rhesus macaque …

Remembering Norton Baskin, 1901-1997, David Nolan

The Marjorie Kinnan Rawlings Journal of Florida Literature

No abstract provided.

Getting The Story, Ann Mccutchan

The Marjorie Kinnan Rawlings Journal of Florida Literature

No abstract provided.

Margorie And Me, Mary W. Bridgman

The Marjorie Kinnan Rawlings Journal of Florida Literature

No abstract provided.

Reforming The Exit Tax, Reuven S. Avi-Yonah

Articles

Code Sec. 877A was enacted in 2008 to impose a significant price on U.S. cit-izens who expatriate. But the price is not right. The quarterly data on expatri-ations (published in the Federal Register since 1998) show an increasing trendsince 2008. For example, 3,422 Americans expatriated in 2022, and the averagesince 2013 was 3,239. By comparison, between 1998 and 2012, fewer than1,000 Americans expatriated each year. This paper will discuss why the increasehappened and what Congress can do about it.

Variation In Antibiotic Resistance Patterns For Children And Adults Treated At 166 Non-Affiliated Us Facilities Using Ehr Data., Shivani Sivasankar, Jennifer Goldman, Mark A. Hoffman

Manuscripts, Articles, Book Chapters and Other Papers

Background: Antibiotic resistance (AR) is a global public health threat. Surveillance of baseline AR and trends and emerging resistance among priority bacterial isolates with respect to the age of the patients and the type of healthcare setting are required due to differences in antimicrobial need and use in these populations.

Methods: We performed a retrospective study using deidentified electronic health record (EHR) data in the Cerner Health Facts™ data warehouse. Antibiotic susceptibility data were extracted for all bacterial isolates of interest at 166 non-affiliated healthcare facilities reporting microbiology susceptibility results of the FDA recommended antibiotics between the years 2012 to …

Transcriptomic Profiles Of Multiple Organ Dysfunction Syndrome Phenotypes In Pediatric Critical Influenza, Tanya Novak, Jeremy Chase Crawford, Georg Hahn, Mark W Hall, Simone A Thair, Margaret M Newhams, Janet Chou, Peter M Mourani, Keiko M Tarquinio, Barry Markovitz, Laura L Loftis, Scott L Weiss, Renee Higgerson, Adam J Schwarz, Neethi P Pinto, Neal J Thomas, Rainer G Gedeit, Ronald C Sanders, Sidharth Mahapatra, Bria M Coates, Natalie Z Cvijanovich, Kate G Ackerman, David W Tellez, Patrick Mcquillen, Stephen C Kurachek, Steven L Shein, Christoph Lange, Paul G Thomas, Adrienne G Randolph

Faculty, Staff and Students Publications

BACKGROUND: Influenza virus is responsible for a large global burden of disease, especially in children. Multiple Organ Dysfunction Syndrome (MODS) is a life-threatening and fatal complication of severe influenza infection.

METHODS: We measured RNA expression of 469 biologically plausible candidate genes in children admitted to North American pediatric intensive care units with severe influenza virus infection with and without MODS. Whole blood samples from 191 influenza-infected children (median age 6.4 years, IQR: 2.2, 11) were collected a median of 27 hours following admission; for 45 children a second blood sample was collected approximately seven days later. Extracted RNA was hybridized …

Characteristics Of Type 2 Diabetes In Female And Male Youth, Beatriz Castillo Rodriguez, Marcela Astudillo, Mustafa Tosur, Ahmad Rafaey, Siripoom Mckay, Fida Bacha, Ashok Balasubramanyam, Maria J Redondo

Faculty, Staff and Students Publications

The incidence of type 2 diabetes in children is rising and carries a worse prognosis than in adults. The influence of sex on pediatric type 2 diabetes outcomes has not been well investigated. We studied 715 youth with type 2 diabetes diagnosed at a median age of 13.7 years and compared sex differences in demographic, clinical, and laboratory characteristics within the first year of diagnosis. Females diagnosed with type 2 diabetes were younger and at a higher stage of pubertal development than males, yet presented with lower A1Cs, a lower prevalence of diabetic ketoacidosis, and higher HDL cholesterol levels.

Prefrontal Network Engagement By Deep Brain Stimulation In Limbic Hubs, Anusha Allawala, Kelly R Bijanki, Denise Oswalt, Raissa K Mathura, Joshua Adkinson, Victoria Pirtle, Ben Shofty, Meghan Robinson, Matthew T Harrison, Sanjay J Mathew, Wayne K Goodman, Nader Pouratian, Sameer A Sheth, David A Borton

Faculty, Staff and Students Publications

Prefrontal circuits in the human brain play an important role in cognitive and affective processing. Neuromodulation therapies delivered to certain key hubs within these circuits are being used with increasing frequency to treat a host of neuropsychiatric disorders. However, the detailed neurophysiological effects of stimulation to these hubs are largely unknown. Here, we performed intracranial recordings across prefrontal networks while delivering electrical stimulation to two well-established white matter hubs involved in cognitive regulation and depression: the subcallosal cingulate (SCC) and ventral capsule/ventral striatum (VC/VS). We demonstrate a shared frontotemporal circuit consisting of the ventromedial prefrontal cortex, amygdala, and lateral orbitofrontal …

Modeling Suicidality With Multimodal Impulsivity Characterization In Participants With Mental Health Disorder, Nidal Moukaddam, Bishal Lamichhane, Ramiro Salas, Wayne Goodman, Ashutosh Sabharwal

Faculty, Staff and Students Publications

INTRODUCTION: Suicide is one of the leading causes of death across different age groups. The persistence of suicidal ideation and the progression of suicidal ideations to action could be related to impulsivity, the tendency to act on urges with low temporal latency, and little forethought. Quantifying impulsivity could thus help suicidality estimation and risk assessments in ideation-to-action suicidality frameworks.

METHODS: To model suicidality with impulsivity quantification, we obtained questionnaires, behavioral tests, heart rate variability (HRV), and resting state functional magnetic resonance imaging measurements from 34 participants with mood disorders. The participants were categorized into three suicidality groups based on their …

Pre-Treatment Inflamed Tumor Immune Microenvironment Is Associated With Folfirinox Response In Pancreatic Cancer, Zachary Gao, Sung Wook Kang, Derek Erstad, Joseph Azar, George Van Buren, William Fisher, Zequn Sun, Mark P Rubinstein, Hyun-Sung Lee, E Ramsay Camp

Faculty, Staff and Students Publications

INTRODUCTION: Pancreatic adenocarcinoma (PDAC) is an aggressive tumor with limited response to both chemotherapy and immunotherapy. Pre-treatment tumor features within the tumor immune microenvironment (TiME) may influence treatment response. We hypothesized that the pre-treatment TiME composition differs between metastatic and primary lesions and would be associated with response to modified FOLFIRINOX (mFFX) or gemcitabine-based (Gem-based) therapy.

METHODS: Using RNAseq data from a cohort of treatment-naïve, advanced PDAC patients in the COMPASS trial, differential gene expression analysis of key immunomodulatory genes in were analyzed based on multiple parameters including tumor site, response to mFFX, and response to Gem-based treatment. The relative …

Reward Sensitivity Predicts The Response To Cognitive Behavioral Therapy For Children With Autism And Anxiety, Matthew J Hollocks, Jeffrey J Wood, Eric A Storch, An-Chuen Cho, Connor M Kerns, Philip C Kendall

Faculty, Staff and Students Publications

Objective: Cognitive-behavioral therapy (CBT) is an effective treatment for anxiety in youth with autism spectrum disorder (ASD). However, research has yet to examine what cognitive characteristics may influence treatment response. The current study investigated decision-making ability and social cognition as potential (a) predictors of differential treatment response to two versions of CBT and (b) moderators of the effect of treatment condition.

Method: The study included 148 children (mean age = 9.8 years) with interfering anxiety and a diagnosis of ASD who were enrolled in a randomized clinical trial comparing two versions of CBT for anxiety (standard and adapted for ASD). …

Novel Banana Lectin Car-T Cells To Target Pancreatic Tumors And Tumor-Associated Stroma, Mary K Mckenna, Ada Ozcan, Daniel Brenner, Norihiro Watanabe, Maureen Legendre, Dafydd G Thomas, Christopher Ashwood, Richard D Cummings, Challice Bonifant, David M Markovitz, Malcolm K Brenner

Faculty, Staff and Students Publications

BACKGROUND: Cell therapies for solid tumors are thwarted by the hostile tumor microenvironment (TME) and by heterogeneous expression of tumor target antigens. We address both limitations with a novel class of chimeric antigen receptors based on plant lectins, which recognize the aberrant sugar residues that are a 'hallmark' of both malignant and associated stromal cells. We have expressed in T cells a modified lectin from banana, H84T BanLec, attached to a chimeric antigen receptor (H84T-CAR) that recognizes high-mannose (asparagine residue with five to nine mannoses). Here, we tested the efficacy of our novel H84T CAR in models of pancreatic ductal …

Emerging Challenges To Cellular Therapy Of Cancer, Premal D Lulla, Malcolm Brenner

Faculty, Staff and Students Publications

Cellular immunotherapy of cancer in the form of chimeric antigen receptor-modified T-cell therapy has become a standard treatment for lymphoid and more recently plasma cell malignancies. Although their successes in these cancers represent a breakthrough for adoptive cell therapy, there are several challenges to their continued growth in the field of cancer medicine. In this review, we discuss the progress made thus far toward achieving "off-the-shelf" accessibility of cell therapies that has the potential to greatly offset the costs associated with the current practice of making patient-specific products. We also review the innovations under investigation that attempt to make cellular …

Sphingolipids In Neurodegenerative Diseases, Xueyang Pan, Debdeep Dutta, Shenzhao Lu, Hugo J Bellen

Faculty, Staff and Students Publications

Neurodegenerative Diseases (NDDs) are a group of disorders that cause progressive deficits of neuronal function. Recent evidence argues that sphingolipid metabolism is affected in a surprisingly broad set of NDDs. These include some lysosomal storage diseases (LSDs), hereditary sensory and autonomous neuropathy (HSAN), hereditary spastic paraplegia (HSP), infantile neuroaxonal dystrophy (INAD), Friedreich’s ataxia (FRDA), as well as some forms of amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD). Many of these diseases have been modeled in Drosophila melanogaster and are associated with elevated levels of ceramides. Similar changes have also been reported in vertebrate cells and mouse models. Here, we …

A Critical Evaluation Of Oral Baclofen In Pediatric Patients With Cerebral Palsy., Matthew J. Mclaughlin, Mark T. Fisher

Manuscripts, Articles, Book Chapters and Other Papers

No abstract provided.