Digital Commons Network^™

Modern Cemented Furlong Hemiarthroplasty: Are Dislocations Rates Better?, C. U. Menakaya, M. Shah, H. Ingoe, R. Malhotra, A. Mannan, T. Boddice, V. Allgar, S. Gopal, A. Mohsen, N. Muthukumar

Peninsula Medical School

Background Dislocation following hip hemiarthroplasty is a major complication with increased mortality and morbidity. Data looking at dislocation following contemporary bipolar stems are lacking in literature. Methods Retrospective review of our prospective national hip fracture database over a two-year period. Group 1 comprised of consecutive patients receiving bipolar Furlong prosthesis (N222) while Group 2 was made up of a historical cohort (uncemented; N254). Clinical and radiological records were reviewed to determine dislocation rates, causes and associative factors of dislocations. Data were analysed using SPSS. Results Following 476 hemiarthroplasties performed during the study period, 12 (2.5%) dislocations were reported (eight in …

On The Trajectory Of Discrimination: A Meta-Analysis And Forecasting Survey Capturing 44 Years Of Field Experiments On Gender And Hiring Decisions, Michael Schaerer, Christilene Du Plessis, My Hoang Bao Nguyen, Robbie C.M.Van Aert, Leo Tiokhin, Daniel Lakens, Elena Giulia Clemente, Thomas Pfeiffer, Anna Dreber, Magnus Johannesson, Cory J. Clark, Gender Audits Forecasting Collaboration, Eric Luis Uhlmann, Ajay T. Abraham, Magdalena Adamus, Cinla Akinci, Federica Alberti, Abdelaziz M. Alsharawy, Shilaan Alzahawi, Frederik Anseel, Felix Arndt, Binnur Balkan, Ernest Baskin, Carrie E. Bearden, Eric G. Benotsch, Stefan Bernritter, Sheila R. Black, Wiebke Bleidorn, Andrew P. Boysen

School of Psychology

A preregistered meta-analysis, including 244 effect sizes from 85 field audits and 361,645 individual job applications, tested for gender bias in hiring practices in female-stereotypical and gender-balanced as well as male-stereotypical jobs from 1976 to 2020. A “red team” of independent experts was recruited to increase the rigor and robustness of our meta-analytic approach. A forecasting survey further examined whether laypeople (n = 499 nationally representative adults) and scientists (n = 312) could predict the results. Forecasters correctly anticipated reductions in discrimination against female candidates over time. However, both scientists and laypeople overestimated the continuation of bias against female candidates. …

Transition Theory And The Emotional Journey To Medical Educator Identity: A Qualitative Interview Study, J Browne, T Collett

Peninsula Medical School

Background. Medical academia is in crisis, with fewer people entering and growing concern at numbers leaving. While faculty development is often seen as part of the solution, there are significant issues with faculty not engaging with and resisting development opportunities. Lack of motivation may be linked to what might be called a ‘weak’ educator identity. We studied medical educators' experiences of career development to gain further insights into: how professional identity may develop; individuals' accompanying emotional responses to perceived identity change; and consideration of the accompanying temporal dimensions. Drawing on new materialist sociology, we explore medical educator identity formation in …

The Microbiomes Of Wildlife And Chemical Pollution: Status, Knowledge Gaps And Challenges, R. D. Handy, N. J. Clark, L. P. Hutt, R. Bescós

School of Biological and Marine Sciences

The effect of chemical pollution on the microbiomes of wildlife has been given little attention. A new concept is emerging where microbiomes are vital to host animal or plant health, and for ecosystems. Data are mainly on mammals, birds, and fish. Changing environmental conditions (e.g., salinity, pH, season) and exposure to chemicals alter the composition of gill, gut and skin microbiomes. Gut microbiomes are also modulated by diet, and exposure to chemicals including metals, nanomaterials, fungicides or microplastics. However, a change in the microbiome does not necessarily infer adverse effects on the host, with some evidence of co-adaptation. Environmental risk …

Recommendations From Diabetes Uk's 2022 Diabetes And Physical Activity Workshop, Anna Morris, Chris Bright, Matthew Cocks, Neil Gibson, Louise Goff, Colin Greaves, Simon Griffin, Ben Jane, Florence Kinnafick, Paul Robb, Michelle Roberts, David Salman, John Saxton, Adrian Taylor, Daniel West, Thomas Yates, Rob C. Andrews, Jason M.R. Gill

Peninsula Medical School

Abstract Aims To describe the process and outputs of a workshop convened to identify key priorities for future research in the area of diabetes and physical activity and provide recommendations to researchers and research funders on how best to address them. Methods A 1‐day research workshop was conducted, bringing together researchers, people living with diabetes, healthcare professionals, and members of staff from Diabetes UK to identify and prioritise recommendations for future research into physical activity and diabetes. Results Workshop attendees prioritised four key themes for further research: (i) better understanding of the physiology of exercise in all groups of people: …

Remediation Technique For Cadmium Contaminated Groundwater: A Systematic Review, Nadia M.T. Jebril, R. Boden, C. Braungardt

School of Biological and Marine Sciences

Heavy metal pollution in soil has seriously affected the living environment of human beings Among all heavy metal pollution, cadmium (Cd) is one of the most difficult to migrate pollutants in soil. Therefore, this systematic review includes the remediation techniques of Cd-contaminated groundwater that using. Different remediation techniques, including pump and treat, permeable reactive barrier, adsorption, biosorption, electrochemical, precipitation, ion exchange and bioremediation are reviewed. The advantages and disadvantages of some remediation technologies for cadmium from groundwater are outlined in order to assist the selection of a suitable technology for a groundwater remediation project. Bioremediation is a common remediation strategy …

Anti-Capsular Activity Of Cuo Nanoparticles Against Acinetobacter Baumannii Produce Efflux Pump, Israa M.S. Al-Kadmy, Sarah Naji Aziz, Ahmed Mahdi Rheima, Suhad Abbas Abid, Ahmed Suhail, Israa Hussein Hamzah, Eman N. Naji, Alexandros Besinis, Helal F. Hetta

School of Engineering, Computing and Mathematics

Copper oxide nanoparticles are modern kinds of antimicrobials, which may get a lot of interest in the clinical application. This study aimed to detect the anti-capsular activity of CuO nanoparticles against Acinetobacter baumannii produce efflux pump. Thirty-four different clinical A. baumannii isolates were collected and identified by the phenotypic and genetic methods by the recA gene as housekeeping. Antibiotic sensitivity and biofilm-forming ability, capsular formation were carried out. The effect of CuO nanoparticles on capsular isolates was detected, the synergistic effects of a combination CuO nanoparticles and gentamicin against A. baumannii were determined by micro broth checkerboard method, and the …

The Experiences Of Uncertainty Amongst Musculoskeletal Physiotherapists In First Contact Practitioner Roles Within Primary Care, Simon Ingram, Robert Stenner, Sue May

School of Health Professions

Aim: The aim of this research was to explore the experiences of uncertainty amongst Musculoskeletal First Contact Practitioners working in primary care.Background: The Musculoskeletal First Contact Practitioner role involves advanced physiotherapists providing an alternative to the GP by acting as first point of contact for people presenting to primary care with musculoskeletal conditions. Limited research into the role exists but the first-contact aspect, clinical complexity and time pressures are deemed to contribute to uncertainty within the role.Method: A qualitative research design was undertaken using a hermeneutic interpretative phenomenological approach. Data was collected using semi-structured interviews with subsequent thematic analysis of …

Dietary Counselling Of Children With Food Allergy, Julia Eisenblaetter

School of Health Professions Theses

Background: The management of food allergy is challenging for children and their families. Several international guidelines recommend involving dietitians in the management; however, their tasks remain uncertain, and the effectiveness of dietary counselling has rarely been investigated. Therefore, the aim of this project was to evaluate the effectiveness of dietary counselling in children with food allergy regarding food allergy related quality of life (QoL), number of allergic reactions, and growth as indicator of nutritional status and diet diversity. Methods: The project was guided by the Complex Intervention Model by the Medical Research Council. To reach the overall aim there needed …

Investigating Letter Identification For Visual Acuity Measurements In The Paracentral Visual Field, Hatem Barhoom

School of Health Professions Theses

Sloan letters are commonly used optotypes in clinical practice, but they exhibit different relative legibility, which may be attributed to response bias, sensitivity differences, and letter similarity. In this thesis, we employed Luce’s choice model and developed a new noisy template model to investigate the role of response bias, sensitivity differences, and letter similarity in letter identification of Sloan letters at central and paracentral locations. Results show that the best model was the one that accounted for the effects of bias, sensitivity, and similarity, with bias contributing more than sensitivity and similarity. However, when estimating the letter acuity from the …

Efficacy And Acceptability Of Mobilisation And Stretches Of The Foot And Ankle In People With Diabetic Peripheral Neuropathy, Vasileios Lepesis

School of Health Professions Theses

People with diabetic peripheral neuropathy and limited joint mobility syndrome (LJMS) can experience increased forefoot peak plantar pressures (PPPs). Elevated PPPs are a risk factor for diabetic neuropathic foot ulceration. Diabetic peripheral neuropathy can also affect balance and increase the risk of falling. This thesis investigated the efficacy and acceptability of foot and ankle mobilisations combined with home stretches in people living at risk of neuropathic diabetic foot ulceration and falling. A systematic review and meta-analysis examined the effects of foot and ankle physical therapy modalities for the management of foot and ankle joint mobility, PPPs, and balance. The review …

Oral Microbes And The Formation Of Cerebral Abscesses: A Single-Centre Retrospective Study, Holly Roy, Raul Bescos, Ewen Mccoll, Umar Rehman, Elizabeth Cray, Louise A. Belfield, King David Nweze, Kevin Tsang, William Singleton, Peter Whitfield, Zoe Brookes

Peninsula Medical School

Objective: Intracranial abscesses are relatively uncommon, but can result in significant mortality and morbidity. Whilst many potential causes of brain abscesses are recognised, in many cases the origin of infection remains clinically unidentified. Our objective was to investigate the role of bacteria found in the oral cavity in the development of brain abscesses. Methods: A retrospective analysis was performed using data from 87 patients admitted to a single UK neurosurgical unit with brain abscesses over a 16-year period. Using microbiological data obtained from abscess sampling and peripheral cultures, species of bacteria were categorised in patients where no primary source of …

Presentation, Management, And Outcomes Of Cauda Equina Syndrome Up To One Year After Surgery, Using Clinician And Participant Reporting: A Multi-Centre Prospective Cohort Study, Julie Woodfield, Ingrid Hoeritzauer, Aimun A.B. Jamjoom, Josephine Jung, Simon Lammy, Savva Pronin, Cathal J. Hannan, Anna Watts, Laura Hughes, Richard D.C. Moon, Stacey Darwish, Holly Roy, Phillip C. Copley, Michael T.C. Poon, Paul Thorpe, Nisaharan Srikandarajah, Gordan Grahovac, Andreas K. Demetriades, Niall Eames, Philip J. Sell, Patrick F.X. Statham, Mohamed Abdelsadg, Motaz Ms Abulaila, Usman Ahmed, Qasim Ajmi, Rafid Al-Mahfoudh, Chadi Ali, Meriem Amarouche, Amin Andalib, M Arora, M Arora, Mariam Awan, Mirza A Baig, Antony Bateman, Iwan Bennett, Imran Bhatti, Peter Bodkin, Lalasa Bommireddy, George Bonanos, Anouk Borg, Alexandros Boukas, James Bourne, Rachael Brennan, J Brown, K Brown, Oliver Burton, Christopher Busby, Neil Chiverton, Simon Clark, Phillip C. Copley, S Cudlip, Y Cunningham, R Dardis, Stacey Darwish, B Davies, Andreas K. Demetriades, S Deore, C Derham, M Dherijha, G Dobson, J Duncan, A Durnford, Aze Durst, Ew Dyson, Niall Eames, Ellie Edlmann, A Edwards-Bailey, A Elserius, B Elson, V Fadelalla, Dm Fountain, A Gardner, A Ghosh, Jr Gill, Sa Glasmacher, R Gordon, Gordan Grahovac, R Grenfell, A Habeebullah, N Haliasos, T Hammett, Cathal J. Hannan, Cs Hill, Ingrid Hoeritzauer, D Holmes, K Hossain-Ibrahim, Laura Hughes, M Hussain, S Hussain, R Ibrahim

Peninsula Medical School

BackgroundCauda equina syndrome (CES) results from nerve root compression in the lumbosacral spine, usually due to a prolapsed intervertebral disc. Evidence for management of CES is limited by its infrequent occurrence and lack of standardised clinical definitions and outcome measures.MethodsThis is a prospective multi-centre observational cohort study of adults with CES in the UK. We assessed presentation, investigation, management, and all Core Outcome Set domains up to one year post-operatively using clinician and participant reporting. Univariable and multivariable associations with the Oswestry Disability Index (ODI) and urinary outcomes were investigated.FindingsIn 621 participants with CES, catheterisation for urinary retention was required …

A Sage And A Guru Walk Into A Bar: Wisdom And Humor Styles, Jeffrey Dean Webster, Sonja Heintz

School of Psychology

Two studies investigated the relationship between wisdom, humor styles, comic styles, and wellbeing. In Study 1, 325 English-speaking college students completed the Self-Assessed Wisdom Scale (SAWS) and the Humor Styles Questionnaire. As predicted, overall wisdom, as well as all five wisdom subscales, was positively correlated with adaptive humor styles. Furthermore, the SAWS humor subscale correlated positively with all humor styles, most strongly with the adaptive styles. In Study 2, 189 German-speaking university students and adults from the general population completed the SAWS, the Comic Style Markers, and measures of positive mental health (meaning in life, optimism, and resilience). The SAWS …

Strategies Are Needed To Support People With Alcohol Use Disorder And Alcohol-Related Liver Disease To Take Part In Randomised Clinical Trials: Results From The Mirage Pilot Trial Of Functional Imagery Training, A Dhanda, V Allgar, J Andrade, L Callaghan, B Hudson, W Ingram, A King, V Lavers, J Lomax, A Mccune, C Musicha, R Parker, C Rollinson, S Creanor

Peninsula Medical School

No abstract provided.

Differential Response And The Reduction Of Child Maltreatment And Foster Care Services Utilization In The U.S. From 2004 To 2017, Michelle Johnson-Motoyama, Donna K. Ginther, Rebecca Phillips, Oliver W.J. Beer, Lisa Merkel-Holguin, John Fluke

School of Health Professions

By 2014, the majority of U.S. states had implemented differential response (DR), a system policy that seeks to serve families of low-to moderate-risk for child maltreatment through family engagement, diversion from formal child protective services investigations, and service provision. However, the effects of DR programs on child welfare dynamics have yet to be evaluated nationally using causal methods. Using a quasi-experimental study design with data drawn from the National Child Abuse and Neglect Data System from 2004 to 2017, we found states with DR programs had approximately 19% fewer substantiated reports, 25% fewer children substantiated for neglect, and a 17% …

Transcatheter Aortic Valve Implantation Versus Surgical Aortic Valve Replacement In Dialysis-Dependent Patients: A Meta-Analysis, Samuel Burton, Alexander Reynolds, Nicola King, Amit Modi, Sanjay Asopa

School of Biomedical Sciences

Objectives This meta-analysis aims to compare the clinical outcomes of transcatheter aortic valve implantation (TAVI) versus aortic valve replacement (AVR) for aortic stenosis in dialysis-dependent patients. Methods Literature searches employed PubMed, Web of Science, Google Scholar and Embase to identify relevant studies. Bias-treated data were prioritized, isolated and pooled for analysis; raw data were utilized where bias-treated data were unavailable. Outcomes were analysed to assess for study data crossover. Results Literature search identified 10 retrospective studies; following data source analysis, five studies were included. Upon pooling of bias-treated data, TAVI was significantly favoured in early mortality [odds ratio (OR), 0.42; …

Decoding Brain Basis Of Laughter And Crying In Natural Scenes, Lauri Nummenmaa, Tuulia Malèn, Sanaz Nazari-Farsani, Kerttu Seppälä, Lihua Sun, Severi Santavirta, Henry K. Karlsson, Matthew Hudson, Jussi Hirvonen, Mikko Sams, Sophie Scott, Vesa Putkinen

School of Psychology

Laughter and crying are universal signals of prosociality and distress, respectively. Here we investigated the functional brain basis of perceiving laughter and crying using naturalistic functional magnetic resonance imaging (fMRI) approach. We measured haemodynamic brain activity evoked by laughter and crying in three experiments with 100 subjects in each. The subjects i) viewed a 20-minute medley of short video clips, and ii) 30 min of a full-length feature film, and iii) listened to 13.5 min of a radio play that all contained bursts of laughter and crying. Intensity of laughing and crying in the videos and radio play was annotated …

Covid-19 And The Physio4fmd Trial: Impact, Mitigating Strategies And Analysis Plans, Louise Marston, Novere M Le, Federico Ricciardi, Irwin Nazareth, Alan Carson, Mark Edwards, Laura H. Goldstein, Jonathan Marsden, Hayley Noble, Markus Reuber, Jon Stone, Rachael M. Hunter, Glenn Nielsen

School of Health Professions

Introduction Functional motor disorder (FMD) is a common cause of disabling neurological symptoms such as weakness and tremor. Physio4FMD is a pragmatic, multicentre single blind randomised controlled trial to evaluate effectiveness and cost effectiveness of specialist physiotherapy for FMD. Like many other studies this trial was affected by the COVID-19 pandemic. Methods The planned statistical and health economics analyses for this trial are described, as well as the sensitivity analyses designed to assess the disruption caused by COVID-19. The trial treatment of at least 89 participants (33%) was disrupted due to the pandemic. To account for this, we have extended …

Air Quality And Mental Health: Evidence, Challenges And Future Directions, Kamaldeep Bhui, Joanne B. Newbury, Rachel M. Latham, Marcella Ucci, Zaheer A. Nasir, Briony Turner, Catherine O'Leary, Helen L. Fisher, Emma Marczylo, Philippa Douglas, Stephen Stansfeld, Simon K. Jackson, Sean Tyrrel, Andrey Rzhetsky, Rob Kinnersley, Prashant Kumar, Caroline Duchaine, Frederic Coulon

School of Biomedical Sciences

Background Poor air quality is associated with poor health. Little attention is given to the complex array of environmental exposures and air pollutants that affect mental health during the life course. Aims We gather interdisciplinary expertise and knowledge across the air pollution and mental health fields. We seek to propose future research priorities and how to address them. Method Through a rapid narrative review, we summarise the key scientific findings, knowledge gaps and methodological challenges. Results There is emerging evidence of associations between poor air quality, both indoors and outdoors, and poor mental health more generally, as well as specific …

Modelling Nhs England 111 Demand For Primary Care Services: A Discrete Event Simulation, R Pilbery, M Smith, J Green, D Chalk, Ca O'Keeffe

School of Health Professions

ObjectivesThis feasibility study aimed to model in silico the current healthcare system for patients triaged to a primary care disposition following a call to National Health Service (NHS) 111 and determine the effect of reconfiguring the healthcare system to ensure a timely primary care service contact.DesignDiscrete event simulation.SettingSingle English NHS 111 call centre in Yorkshire.ParticipantsCallers registered with a Bradford general practitioner who contacted the NHS 111 service in 2021 and were triaged to a primary care disposition.Primary and secondary outcome measuresFace validity of conceptual model. Comparison between real and simulated data for quarterly counts (and 95% CIs) for patient contact …

The Impact Of Myosteatosis On Outcomes Following Surgery For Gastrointestinal Malignancy: A Meta-Analysis, A Maccormick, A Streeter, M Puckett, Somaiah Aroori

Peninsula Medical School

INTRODUCTION: The aim of this review was to evaluate the impact of preoperative myosteatosis on long-term outcomes following surgery for gastrointestinal malignancy.

METHODS: We conducted a systematic search of the electronic information sources, including PubMed MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), CINAHL and AMED. Studies were included if they reported the impact of preoperatively defined myosteatosis, or a similar term, on long-term survival outcomes following surgery for gastrointestinal malignancy. A subgroup analysis was performed for those studies reporting outcomes for colorectal cancer patients only.

FINDINGS: Thirty-nine full-text articles were reviewed for inclusion, with 19 being retained after …

Evaluation Of A Complex Intervention For Prisoners With Common Mental Health Problems, Near To And After Release: The Engager Randomised Controlled Trial, Richard Byng, Tim Kirkpatrick, Charlotte Lennox, Fiona C. Warren, Rob Anderson, Sarah Louise Brand, Lynne Callaghan, Lauren Carroll, Graham Durcan, Laura Gill, Sara Goodier, Jonathan Graham, Rebecca Greer, Mark Haddad, Tirril Harris, William Henley, Rachael Hunter, Sarah Leonard, Mike Maguire, Susan Michie, Christabel Owens, Mark Pearson, Cath Quinn, Sarah Rybczynska-Bunt, Caroline Stevenson, Amy Stewart, Alex Stirzaker, Roxanne Todd, Florian Walter, Lauren Weston, Nat Wright, Rod S. Taylor, Jenny Shaw

Peninsula Medical School

Background Many male prisoners have significant mental health problems, including anxiety and depression. High proportions struggle with homelessness and substance misuse. Aims This study aims to evaluate whether the Engager intervention improves mental health outcomes following release. Method The design is a parallel randomised superiority trial that was conducted in the North West and South West of England (ISRCTN11707331). Men serving a prison sentence of 2 years or less were individually allocated 1:1 to either the intervention (Engager plus usual care) or usual care alone. Engager included psychological and practical support in prison, on release and for 3–5 months in …

Inhibition Of Yap/Taz-Driven Tead Activity Prevents Growth Of Nf2-Null Schwannoma And Meningioma, Liyam Laraba, Lily Hillson, Julio Grimm De Guibert, Amy Hewitt, Maisie R Jaques, Tracy T Tang, Leonard Post, Emanuela Ercolano, Ganesha Rai, Shyh-Ming Yang, Daniel J Jagger, Waldemar Woznica, Philip Edwards, Aditya G Shivane, C Oliver Hanemann, David B Parkinson

Peninsula Medical School

Schwannoma tumours typically arise on the eighth cranial nerve and are mostly caused by loss of the tumour suppressor Merlin (NF2). There are no approved chemotherapies for these tumours and the surgical removal of the tumour carries a high risk of damage to the eighth or other close cranial nerve tissue. New treatments for schwannoma and other NF2-null tumours such as meningioma are urgently required. Using a combination of human primary tumour cells and mouse models of schwannoma, we have examined the role of the Hippo signalling pathway in driving tumour cell growth. Using both genetic ablation of the Hippo …

Assessing The Association Between Overcrowding And Human Physiological Stress Response In Different Urban Contexts: A Case Study In Salzburg, Austria, Zhaoxi Zhang, Kristýna Měchurová, Bernd Resch, Prince Amegbor, Clive E. Sabel

School of Geography, Earth and Environmental Sciences

Overcrowding in densely populated urban areas is increasingly becoming an issue for mental health disorders. Yet, only few studies have examined the association between overcrowding in cities and physiological stress responses. Thus, this study employed wearable sensors (a wearable camera, an Empatica E4 wristband and a smartphone-based GPS) to assess the association between overcrowding and human physiological stress response in four types of urban contexts (green space, transit space, commercial space, and blue space). A case study with 26 participants was conducted in Salzburg, Austria. We used Mask R-CNN to detect elements related to overcrowding such as human crowds, sitting …

Impact Of Digital Technologies On Self-Efficacy In People With Parkinson’S: A Scoping Review Protocol, Andrew Michael Hall, Sree Aroori, Camille B. Carroll, Edward Meinert, Victoria Allgar

Peninsula Medical School

Introduction Parkinson’s disease (PD) is the second most common neurological disease globally, for which currently no one definitive cause or cure exists. Estimates suggest that 145 000 people with Parkinson’s (PwP) live in the UK. PD presents with motor and non-motor symptoms fluctuating significantly in and between individuals continually throughout the day. PD adversely affects activities of daily living, quality of life and well-being. Self-efficacy is an important belief to improve for PwP as it enables the individual to develop confidence in their ability to exert control over their own motivation, behaviour and social environment. This scoping review aims to …

Hmp-Reader: Menpa Guidelines For Designing And Reporting Research On Holistic Movement Practices, Including Yoga, Tai Chi, Qigong, And Conscious Dance, Ineke Vergeer, Adrian Taylor, Mats Hallgren, Stuart J.H. Biddle

Peninsula Medical School

No abstract provided.

Drugless And Radiographer Led: The Start Of A New Era For Ct Coronary Angiography, Gareth Morgan-Hughes, Rebecca Mcnally, Christopher Gibbs Gibbs, Stelios Iacovides, Prabesh Kirat-Rai, Nang Thiriphoo, Alison Powell, Colin Stuckey, Ross Thorpe, Louisa Mayo, Carl Roobottom

Peninsula Medical School

Objective. Since inception CT coronary angiography (CTCA) has required facilitating beta blockers (BB). However, CT technology has improved rapidly as has radiographer and reporter expertise. Using these factors, we instituted a radiographer led cardiac CT service (RLCCTS), without routine BB, which we studied for quality control (QC). Methods. RLCCTS started October 2021 using a wide detector array CT system, with 20 min slots. QC study was registered with the clinical audit team, University Hospitals Plymouth, CA_2020-21-118. Uniform reporting was agreed including indication, BB administration, demographics, dose length product (DLP) and the coronary artery disease—reporting and data system (CAD-RADS) score. Uncertain …

Genome-Wide Analysis Of Motor Progression In Parkinson Disease, Carrasco A Martínez, R Real, M Lawton, Reynolds R Hertfelder, M Tan, L Wu, N Williams, C Carroll, J-C Corvol, M Hu, D Grosset, J Hardy, M Ryten, Y Ben-Shlomo, M Shoai, Hr Morris

Peninsula Medical School

Background and Objectives The genetic basis of Parkinson disease (PD) motor progression is largely unknown. Previous studies of the genetics of PD progression have included small cohorts and shown a limited overlap with genetic PD risk factors from case-control studies. Here, we have studied genomic variation associated with PD motor severity and early-stage progression in large longitudinal cohorts to help to define the biology of PD progression and potential new drug targets. Methods We performed a GWAS meta-analysis of early PD motor severity and progression up to 3 years from study entry. We used linear mixed-effect models with additive effects, …

National Study Of Nafld Management Identifies Variation In Delivery Of Care In The Uk Between 2019 To 2022, Wenhao Li, David Sheridan, Stuart Mcpherson, William Alazawi, Kush Abeysekera, Tom Marjot, Paul Brennan, Sara Mahgoub, Tessa Cacciottolo, Theresa Hydes, Tim Hardy, Gio Mcginty, Oliver Tavabie, Jennifer Cathcart, Chirantha Premathilaka, Ashis Mukhopadhya, Arshiya Bhat, Shahnaz Begum, Bashar Abushaban, Meha Bhuva, Sophie Sinclair, Damien Leith, Cullen Mcculloch, Joanna Leithead, Richard Fox, Mh Shah, Eugene Campbell, Edward Brown, Dina Mansour, F Shah, Michael Allison, Jonathan Chan, Victoria Roberts, Gautham Appanna, Mandour Omer Mandour, Georgina Slee, Vicki Wong, Sreelakshmi Kotha, Katrina Pekarska, Richard Parker, Cyril Sieberhagen, Thomas Ngan, Esra Asilmaz, Hamish Miller, Jeremy Cobbold, Dom Crocombe, Manolis Tsochatzis, Sudeep Tanwar, Aruna Dias, Gurmit Singh, S Agrawal, P Chhabra, A Gurung, R Veettil, Rd Abeles, D Chatterjee, M Carbonell, Z Mohamed, A El-Sayed, A Johnson, Damien Leith, S Barclay, K Kelly, J Munonye, D Coates, O Bamidele, T Johnston, D Samuel, B Ball, R Arscott-Samuel, P Hams, M Armstrong, A Elkhol, K Shailesh, V Bains, P Manousou, T Gupta, S Than, E Unitt, V Gordon, A Wakefield, S Gilchrist, I Cozma, S Saeed, S Umrani, K Olsen

Peninsula Medical School

Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is associated with liver and cardiovascular morbidity and mortality. Recently published NAFLD Quality Standards include 11 key performance indicators (KPIs) of good clinical care. This national study, endorsed by British Association for the Study of the Liver (BASL) and British Society of Gastroenterology (BSG), aimed to benchmark NAFLD care in UK hospitals against these KPIs. Methods: This study included all new patients with NAFLD reviewed in the outpatient clinic in the months of March 2019 and March 2022. Participating UK hospitals self-registered for the study through BASL/BSG. KPI outcomes were compared using …