Digital Commons Network^™

The Organizational Outcomes Of Supervision In Settings Addressing Violence Against Women: A Scoping Review, Margaret Janse Van Rensburg, Maria Peddle, Karen Sewell, Claire Mcmenemy, Heather Macdonald

Faculty and Staff Publications

Violence against women (VAW) is a prevailing social issue which requires human service organizations to provide a range of services to survivors. Workplace-based supervision in settings that seek to address VAW is an essential component of quality service. This scoping review of seven studies maps the available evidence of supervision in settings that seek to address VAW. Research studies were identified through sub-sampling literature identified in a scoping review on the organizational outcomes of supervision in the human services summarizing the evidence published between 2011 and 2022 including all articles which specifying a VAW setting. Guided by scoping review methodology, …

Pediatric Necrobiotic Xanthogranuloma As A Novel Phenotype Of Ikaros Gain Of Function, Rachel Guess, George Harocopos, Jeffrey J Bednarski, Lynn M Hassmann, Tarin M Bigley

2020-Current year OA Pubs

No abstract provided.

Effectiveness And Safety Of Different Estradiol Regimens In Transgender Women (Treat Study): Protocol For A Randomized Controlled Trial, Samuel Cortez, Dominic Moog, Christopher Lewis, Kelley Williams, Cynthia Herrick, Melanie Fields, Teddi Gray, Zhaohua Guo, Ginger Nicol, Thomas Baranski

2020-Current year OA Pubs

BACKGROUND: Current guidelines for gender-affirming hormone therapy (GAHT) for transgender women are mostly based on clinical experience from experts in the field and treatments used on postmenopausal women. While care is currently provided with the best available evidence, there is a critical gap in knowledge about the safest and most effective estradiol routes of administration for GAHT in transgender women; this statement is supported by the World Professional Association for Transgender Health on their Standards of Care for the Health of Transgender and Gender Diverse People, version 8. Furthermore, the reported rates of cardiometabolic adverse events in transgender women highlight …

Leveraging Mhealth To Mitigate The Impact Of Covid-19 In Black American Communities: Qualitative Analysis, Kelly M Harris, Tilicia Mayo Gamble, Madelyn G Yoo, Lindsay A Spell, Timira N Minor, Holly Jones, Donald Lynch

2020-Current year OA Pubs

BACKGROUND: COVID-19 remains an ongoing public health crisis. Black Americans remain underrepresented among those vaccinated and overrepresented in both COVID-19 morbidity and mortality. Medical misinformation, specifically related to COVID-19, has exacerbated the impact of the disease in Black American communities. Communication tools and strategies to build relationships and disseminate credible and trustworthy diagnostic and preventative health information are necessary to improve outcomes and equity for historically oppressed populations.

OBJECTIVE: As the initial phase of a larger mixed methods project to develop, pilot, and evaluate a mobile health (mHealth) intervention among a population at high risk for COVID-19 and cardiovascular comorbidities, …

A History Of The Scottish P.E.N. Organization, Part 1: 1927-1949, Helen Stoddart

Studies in Scottish Literature

The first article in a two-part series charting the history of Scottish PEN, from its founding in 1927, through political struggles in the 1930s, and at the international congress in Edinburgh in 1934, over issues of intellectual freedom and the rise of Hitler, till the need to reestablish the organization after World War II, exploring Scottish PEN's relationship to the 20th century Scottish Renaissance movement, and examining the roles in Scottish PEN of H.J.C. Grierson, C.M. Grieve (Hugh MacDiarmid), Helen Cruikshank, William Power, Willa and Edwin Muir, and many others.

“They Act Like We Are Going To Heaven”: Pre-Arrival Information Experiences, Information Crafting And Settlement Of Immigrants In Canada, Nafiz Z. Shuva

Publications and Research

Purpose

Although there is a growing body of work on immigrants' information behavior, little is known about the pre-arrival information experiences of immigrants who consult formal information sources such as immigration agents. Drawn from a larger study on the information behavior of immigrants, this paper mainly reports the semi-structured interview findings on the pre-arrival information experiences of Bangladeshi immigrants who used formal information sources with discussion on how that affected their post-arrival settlement into Canada.

Design/methodology/approach

The study used a mixed method approach with semi-structured interviews (n = 60) and surveys (n = 205) with participants who arrived in Canada …

Are Human-Like Robots Trusted Like Humans? An Investigation Into The Effect Of Anthropomorphism On Trust In Robots Measured By Expected Value As Reflected By Feedback Related Negativity And P300, Lucy Olivia Wilson

The Plymouth Student Scientist

Robots are becoming more prevalently used in industry and society. However, in order to ensure effective use of the trust, must be calibrated correctly. Anthropomorphism is one factors which is important in trust in robots (Hancock et al., 2011). Questionnaires and investment games have been used to investigate the impact of anthropomorphism on trust, however, these methods have led to disparate findings. Neurophysiological methods have also been used as an implicit measure of trust. Feedback related negativity (FRN) and P300 are event related potential (ERP) components which have been associated with processes involved in trust such as outcome evaluation. This …

Diversity And Bioactive Potential Of Leaf-, And Root Sediment-Associated Bacteria From Zostera Marina In The Yealm Estuary, Southwest England, Eva Capps

The Plymouth Student Scientist

Increasing antimicrobial resistance (AMR) among human pathogenic bacteria demands urgent efforts to uncover novel natural products for developing new antibiotic drugs. Since terrestrial sources of natural products are overmined, attention in biodiscovery is shifting towards marine microbial ecosystems which are subject to unique environmental stressors. Resulting metabolic adaptations provide potential for potent antibacterial compounds. Thus, the microbiomes of seagrass components in Zostera marina, and the activity of culturable isolates against human pathogens, were explored in this study. The sample site used was in the Yealm Estuary, Southwest England, a location previously unexplored in this context. Seagrass leaves at 20cm and …

Fostering Academic Literacy And Unveiling Student Excellence In Stem (Science, Technology, Engineering, And Mathematics) Research At The University Of Plymouth, Uk, Jason B. Truscott

The Plymouth Student Scientist

Six years ago, when I stepped into the role of Editor for this journal, I couldn't have foreseen the incredible wealth of talent nestled within the student cohort at the University of Plymouth (Truscott, 2018). The journey through their undergraduate research endeavours has been truly remarkable, a testament not just to their inherent abilities but also to the exceptional guidance provided by their research project supervisors and external sponsors. Each passing year unfolds as a unique odyssey through the diverse realms of STEM (Science, Technology, Engineering, and Mathematics), all thanks to the steadfast commitment of these students to inquiry within …

Testing The Potential Use Of Uk Wetland Plant Species In Paludiculture Using Examples From The Somerset Levels, Olivia Bentley

The Plymouth Student Scientist

The trade-off between economic benefits and environmental sustainability results in the unsustainable use of wetlands through conversion to agricultural land. As a result, causing peat degradation, reducing the ecosystem’s capacity to provide ecosystem services. Paludiculture, the concept of cultivating wetland plant species in rewetted conditions that can be converted and utilised commercially, presents an opportunity to harmonise economic stability and environmental protection. However, most research into paludiculture has been conducted in continental Europe; there is a knowledge gap regarding paludiculture in the UK. In this research, seven UK wetland plant species were harvested from the Somerset Levels, a low-lying wetland …

The Role Of Colony Morphology And Substratum Inclination On The Distribution Of Eunicella Verrucosa On Shallow Reefs, Luke Thompson

The Plymouth Student Scientist

Eunicella verrucosa plays an important role in shallow reefs, where they produce a complex 'sheet tree' morphology that supports a variety of benthic-dwelling organisms. E. verrucosa is considered 'vulnerable' by the IUCN Red List, which validates the importance of understanding the biotic and abiotic factors influencing the species morphology and survival. This study analyses how horizontal and vertical slope inclinations influence colony morphology. A population of 115 E. verrucosa colonies were observed at Plymouth's inner breakwater fort at 8–13.8m in depth. The influence of inclination on morphology was investigated by observing colony height, encrusting branch diameter and branch complexity for …

Impact Of Marine Heatwaves On The Physiological Health Of Two Fucoid Species, Lily Burnet

The Plymouth Student Scientist

Marine Heatwaves (MHWs) are periods of high-water temperature that have become an increasingly significant threat to marine ecosystem biodiversity in recent decades with rising anthropogenic carbon driving greater severity of MHW events. The two intertidal fucoid species, Fucus serratus and Fucus vesiculosus, are keystone primary producers supporting an extensive biodiverse community of associated flora and fauna. As intertidal species, fucoids are adapted to cope with high atmospheric temperatures during exposure at low tide, however, are prone to changes in abundance, distribution, and life cycles during MHW events. Changes to fucoid communities resulting in reduced primary production and habitat biomass will …

Diversity, Abundance, And Distribution Of Ground Invertebrates In Lower Sharpham Farm, Valeria Zavala Quiroga

The Plymouth Student Scientist

Invertebrates constitute the largest group of animals on Earth and represent the bulk of biodiversity. They are responsible for numerous essential ecosystems services and are at the centre of many terrestrial food webs. Due to habitat loss from land use change and conversion to intensive agriculture, they are experiencing a substantial decline in biodiversity, hence conservation approaches such as rewilding have been sought. There are limited studies of invertebrate biodiversity in rewilding projects, therefore the aim of this study is to investigate the diversity and abundance of ground invertebrates at Lower Sharpham Farm and the influences of vegetation structure in …

The Different Factors Affecting Chiroptera Emergences With A Focus On Pipistrellus Pipistrellus And Pipistrellus Pygmaeus, Hannah Mccabe

The Plymouth Student Scientist

Chiroptera (bats) are important within different ecosystems and biomes due to the different ecosystem services that they provide. The services that they provide to the United Kingdom include organic agricultural pest control and worldwide bats provide pollination and seed dispersal. The rationale for this study is to understand emergence preferences based on natural and anthropogenic factors such as building structure, habitats, and time. Bat roosts are species specific, with urban exploiter species relying on urban habitats such as Pipistrellus pipistrellus and urban-adapter species such as Nyctalus noctule relying on natural roosts. A range of surveys sites were studied across, Hampshire …

A Statistical Analysis Of The Population Of Barbel In The River Teme

The Plymouth Student Scientist

The focus of this project is on the population of barbel (Barbus barbus) living in the River Teme, over a number of years with the objective of examining the fish population size specifically investigating any temporal trend in fish population numbers and, if found, with the further aim of examining any covariates that may be causing the trend. In order to answer these questions, two datasets were investigated and rigorously analysed in order to ascertain whether stocks of barbel are in decline and, if so, to further examine which covariates could be contributing to their depletion. A number of statistical …

Covid-19 Response In An Alternative America: Legal Tools That The Us Government Failed To Invoke, Neil Davey

Minnesota Journal of Law, Science & Technology

No abstract provided.

Safety And Efficacy Of Ixoberogene Soroparvovec In Neovascular Age-Related Macular Degeneration In The United States (Optic): A Prospective, Two-Year, Multicentre Phase 1 Study, Arshad M. Khanani, David S. Boyer, Charles C. Wykoff, Carl D. Regillo, Brandon G. Busbee, Dante Pieramici, Carl J. Danzig, Brian C. Joondeph, James C. Major, Adam Turpcu, Szilárd Kiss

Wills Eye Hospital Papers

Background

Gene therapy, successfully used in rare, monogenetic disorders, may prove to be a durable management approach for common, polygenetic conditions, including neovascular age-related macular degeneration (nAMD). Repeated injections, oftentimes monthly, and possibly for decades, of vascular endothelial growth factor antagonists (anti-VEGF), is the standard for nAMD. We hypothesised that an in-office, intravitreal administration of ixoberogene soroparvovec (ixo-vec, formerly ADVM-022), a single-dose gene therapy encoding for the proven anti-VEGF protein, aflibercept, would transform retinal cells to continually produce aflibercept to minimise treatment burden in nAMD.

Methods

In this two-year, open-label, prospective, multicentre phase 1 study, patients with nAMD responding to …

The Function Of Ask1 In Sepsis And Stress-Induced Disorders, John Kostyak, Steven Mckenzie, Ulhas Naik

Cardeza Foundation for Hematologic Research

Apoptosis signal-regulating kinase 1 (ASK1) is a serine-threonine kinase that is ubiquitously expressed in nucleated cells and is responsible for the activation of multiple mitogen-activated protein kinases (MAPK) to regulate cell stress. Activation of ASK1 via cellular stress leads to activation of downstream signaling components, activation of transcription factors, and proinflammatory cytokine production. ASK1 is also expressed in anucleate platelets and is a key player in platelet activation as it is important for signaling. Interestingly, the mechanism of ASK1 activation is cell type-dependent. In this review we will explore how ASK1 regulates a variety of cellular processes from innate immune …

Desmoglein-2 As A Cancer Modulator: Friend Or Foe?, Kay Myo Min, Charlie Ffrench, Barbara Mcclure, Michael Ortiz, Emma Dorward, Michael Samuel, Lisa Ebert, Mỹ Mahoney, Claudine Bonder

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Desmoglein-2 (DSG2) is a calcium-binding single pass transmembrane glycoprotein and a member of the large cadherin family. Until recently, DSG2 was thought to only function as a cell adhesion protein embedded within desmosome junctions designed to enable cells to better tolerate mechanical stress. However, additional roles for DSG2 outside of desmosomes are continuing to emerge, particularly in cancer. Herein, we review the current literature on DSG2 in cancer and detail its impact on biological functions such as cell adhesion, proliferation, migration, invasion, intracellular signaling, extracellular vesicle release and vasculogenic mimicry. An increased understanding of the diverse repertoire of the biological …

Embedding Patient Input In Outcome Measures For Long‐Term Disease‐Modifying Parkinson Disease Trials, C Gonzalez‐Robles, Michèle Bartlett, Matthew Burnell, Caroline S. Clarke, Shlomi Haar, Michele T. Hu, Brook Huxford, Ashwani Jha, Michael Lawton, Alastair Noyce, Paola Piccini, Kuhan Pushparatnam, Lynn Rochester, Carroll Siu, Wamelen D Van, Ch Williams‐Gray, Marie Louise Zeissler, Henrik Zetterberg, Camille B. Carroll, Thomas Foltynie, Rimona S. Weil, Anette Schrag

Peninsula Medical School

Background Clinical trials of disease-modifying therapies in PD require valid and responsive primary outcome measures that are relevant to patients. Objectives The objective is to select a patient-centered primary outcome measure for disease-modification trials over three or more years. Methods Experts in Parkinson's disease (PD), statistics, and health economics and patient and public involvement and engagement (PPIE) representatives reviewed and discussed potential outcome measures. A larger PPIE group provided input on their key considerations for such an endpoint. Feasibility, clinimetric properties, and relevance to patients were assessed and synthesized. Results Although initial considerations favored the Movement Disorder Society-sponsored revision of …

Adjuvant Pluronic F68 Is Compatible With A Plant Root-Colonizing Probiotic, Pseudomonas Chlororaphis O6, Amanda R. Streeter, Anthony Cartwright, Mohammad Zargaran, Anagha Wankhade, Anne J. Anderson, David W. Britt

Biological Engineering Faculty Publications

Plant probiotic bacteria are being increasingly used to maximize both the productivity and quality of field crops. Pseudomonas chlororaphis O6 (PcO6) is a plant root colonizer with probiotic activities. This bacterium produces an array of metabolites, including a group of phenazines that are functional in plant protection. The paper reports responses of PcO6 to a nonionic triblock copolymer surfactant, Pluronic F68. This Pluronic exhibits membrane "healing" activity and improves cryopreservation recovery in eukaryotic cells. The product is FDA-approved and is applied as an adjuvant in formulations used in agriculture, medicine, and biotechnology. Growth of PcO6 on …

Pivotal Trial Of A Deep-Learning-Based Retinal Biomarker (Reti-Cvd) In The Prediction Of Cardiovascular Disease: Data From Cmerc-Hi, Chan Joo Lee, Tyler Hyungtaek Rim, Hyun Goo Kang, Joseph Keunhong Yi, Geunyoung Lee, Marco Yu, Soo-Hyun Park, Jin-Taek Hwang, Yih-Chung Tham, Tien Yin Wong, Ching-Yu Cheng, Dong Wook Kim, Sung Soo Kim, Sungha Park

The Brown Foundation: Institute of Molecular Medicine

Objective: The potential of using retinal images as a biomarker of cardiovascular disease (CVD) risk has gained significant attention, but regulatory approval of such artificial intelligence (AI) algorithms is lacking. In this regulated pivotal trial, we validated the efficacy of Reti-CVD, an AI-Software as a Medical Device (AI-SaMD), that utilizes retinal images to stratify CVD risk.

Materials and methods: In this retrospective study, we used data from the Cardiovascular and Metabolic Diseases Etiology Research Center-High Risk (CMERC-HI) Cohort. Cox proportional hazard model was used to estimate hazard ratio (HR) trend across the 3-tier CVD risk groups (low-, moderate-, and high-risk) …

Regulating The Revolution: A Legal Roadmap To Optimizing Ai In Healthcare, Fazal Khan

Minnesota Journal of Law, Science & Technology

No abstract provided.

Crawling To The Cure: The Monopolization Of The Breast Cancer Drug Market, Kira Le

Minnesota Journal of Law, Science & Technology

No abstract provided.

Autocrine Igf-Ii-Associated Cancers: From A Rare Paraneoplastic Event To A Hallmark In Malignancy, Pierluigi Scalia, Ignazio R. Marino, Salvatore Asero, Giuseppe Pandini, Adda Grimberg, Wafik S. El-Deiry, Stephen J. Williams

Department of Surgery Faculty Papers

The paraneoplastic syndrome referred in the literature as non-islet-cell tumor hypoglycemia (NICTH) and extra-pancreatic tumor hypoglycemia (EPTH) was first reported almost a century ago, and the role of cancer-secreted IGF-II in causing this blood glucose-lowering condition has been widely established. The landscape emerging in the last few decades, based on molecular and cellular findings, supports a broader role for IGF-II in cancer biology beyond its involvement in the paraneoplastic syndrome. In particular, a few key findings are constantly observed during tumorigenesis, (a) a relative and absolute increase in fetal insulin receptor isoform (IR^A) content, with (b) an increase …

This Land Is Our Land: Tree Planting And Environmental Construction On The Nebraska Prairie, Megan Sue Launchbaugh

History Theses, Dissertations, and Student Creative Activity

In 1895 the Nebraska Legislature passed a bill officially adopting the nickname the “Tree Planter’s State” on account of the founding of Arbor Day, the Timber Culture Act of 1873, and the “millions of trees planted by early settlers as windbreaks, woodlots, and orchards.” Since that time, Arbor Day and the Timber Culture Act have been the subject of countless historical studies, while the subject of settler tree planting remains largely unexplored. This thesis seeks to begin establishing a place for the stories, experiences, and legacy of settler tree planting within the regional narrative by examining the cultural, physical, and …

“Storm Of Insanity”: The Chaotic Nature Of Relief Work And Financial Compensation Following The Johnstown Flood Of 1889, Carly N. Marze

History Theses, Dissertations, and Student Creative Activity

On May 31, 1889, the South Fork dam ruptured, and the resulting wall of water pummeled through the small town of Johnstown, Pennsylvania, killing over 2,000 people. The cause was negligence by the dam’s proprietors at the South Fork Fishing & Hunting Club. As bodies lay scattered throughout the Conemaugh Valley and Johnstown sat nearly twenty-feet deep in mud and debris, two questions arose: What relief work should be done to restore Johnstown? And how should this relief be financed? Lack of resources and the urgency of the work created a chaotic atmosphere in which constantly shifting procedures and disputes …

Para-Infectious Brain Injury In Covid-19 Persists At Follow-Up Despite Attenuated Cytokine And Autoantibody Responses, Benedict D Michael, Cordelia Dunai, Edward J Needham, Kukatharmini Tharmaratnam, Robyn Williams, Yun Huang, Sarah A Boardman, Jordan J Clark, Parul Sharma, Krishanthi Subramaniam, Greta K Wood, Ceryce Collie, Richard Digby, Alexander Ren, Emma Norton, Maya Leibowitz, Soraya Ebrahimi, Andrew Fower, Hannah Fox, Esteban Tato, Mark A Ellul, Geraint Sunderland, Marie Held, Claire Hetherington, Franklyn N Egbe, Alish Palmos, Kathy Stirrups, Alexander Grundmann, Anne-Cecile Chiollaz, Jean-Charles Sanchez, James P Stewart, Michael Griffiths, Tom Solomon, Gerome Breen, Alasdair J Coles, Nathalie Kingston, John R Bradley, Patrick F Chinnery, Jonathan Cavanagh, Sarosh R Irani, Angela Vincent, J Kenneth Baillie, Peter J Openshaw, Malcolm G Semple, Covid-Cns Consortium, Isaric4c Investigators, Leonie S Taams, David K Menon

Faculty, Staff and Student Publications

To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1-11 days post-admission) and 92 convalescent sera (56 with COVID-19-associated neurological diagnoses). Here we show that compared to 60 uninfected controls, tTau, GFAP, NfL, and UCH-L1 are increased with COVID-19 infection at acute timepoints and NfL and GFAP are significantly higher in participants with neurological complications. Inflammatory mediators (IL-6, IL-12p40, HGF, M-CSF, CCL2, and IL-1RA) are associated with both altered consciousness and markers of brain injury. Autoantibodies are more common …

Decentralized Computing For Reliable Home Automation, Rahav Dor

McKelvey School of Engineering Graduate Student Theses & Dissertations

Smart homes are distributed systems that should provide reliable home automation services. Distributed controllers have been used to improve the reliability of smart homes. However, despite the redundancy in controllers, the reliability of smart homes is hindered by the unreliable network infrastructure comprising home Wi-Fi and low-power wireless networks. As a result, smart homes cannot be trusted with much more than casual automation to date. This dissertation identifies the limitations of traditional fault-tolerant approaches that require inter-controller coordination over an unreliable network infrastructure. A new class of decentralized control paradigm named Banyan, with fully autonomous controllers, is introduced by this …

Mechanisms And Prevention Of Antibiotic Resistant Organism Spread In Hospitals, Erin P. Newcomer

McKelvey School of Engineering Graduate Student Theses & Dissertations

Our quest as a species to treat and prevent disease has led us to develop medical care that would have been inconceivable even one century ago. However, as we learn to overcome previous roadblocks, new hurdles that we hadn’t even considered continue to present themselves. Once we learned to understand the germ theory of disease, we sought treatments for infectious diseases, which led us to the development of antibiotics. Antibiotics are responsible for saving countless lives and have ushered in the advances in other fields of medicine like cancer treatment and surgery. Now, antibiotic resistance threatens our ability to treat …