Digital Commons Network^™

Effects Of Hepatic Mitochondrial Pyruvate Carrier Deficiency On De Novo Lipogenesis And Gluconeogenesis In Mice, Nicole K H Yiew, Stanislaw Deja, Daniel Ferguson, Kevin Cho, Chaowapong Jarasvaraparn, Miriam Jacome-Sosa, Andrew J Lutkewitte, Sandip Mukherjee, Xiaorong Fu, Jason M Singer, Gary J Patti, Shawn C Burgess, Brian N Finck

2020-Current year OA Pubs

The liver coordinates the systemic response to nutrient deprivation and availability by producing glucose from gluconeogenesis during fasting and synthesizing lipids via

Mutation Of Key Signaling Regulators Of Cerebrovascular Development In Vein Of Galen Malformations, Shujuan Zhao, Po-Ying Fu, Yung-Chun Wang, Sheng Chih Jin, Et Al.

2020-Current year OA Pubs

To elucidate the pathogenesis of vein of Galen malformations (VOGMs), the most common and most severe of congenital brain arteriovenous malformations, we performed an integrated analysis of 310 VOGM proband-family exomes and 336,326 human cerebrovasculature single-cell transcriptomes. We found the Ras suppressor p120 RasGAP (RASA1) harbored a genome-wide significant burden of loss-of-function de novo variants (2042.5-fold, p = 4.79 x 10

Sustainability Determinants Of An Intervention To Identify Clinical Deterioration And Improve Childhood Cancer Survival In Latin American Hospitals: The Inspire Study Protocol, Virginia Mckay, Bobbi Carothers, Dylan Graetz, Sara Malone, Maria Puerto-Torres, Kim Prewitt, Adolfo Cardenas, Yichen Chen, Meenakshi Devidas, Douglas A Luke, Asya Agulnik

2020-Current year OA Pubs

BACKGROUND: More than 90% of children with cancer live in low-resourced settings, where survival is only 20%. Sustainable evidence-based (EB) interventions yielding ongoing beneficial patient outcomes are critical to improve childhood cancer survival. A better understanding of factors promoting intervention sustainability in these settings is urgently needed. The aim of this study is to provide an empirical understanding of how clinical capacity for sustainability, or the resources needed to sustain an intervention, impacts the sustainment of Pediatric Early Warning System (PEWS), an EB intervention that improves pediatric oncology outcomes in low-resource hospitals by detecting clinical deterioration and preventing the need …

An Intersection Of Science & Art: Vitrification Approaches And Open-Fabricated Tools For The Biomedical Model Sea Hare, Aplysia Californica, Allyssa M. Oune

LSU Master's Theses

The California sea hare (Aplysia californica) is an important biomedical model for molecular neurobiology, electrophysiology, learning, and memory due to their well-mapped and large neurons and well-characterized learning capabilities. The National Resource for Aplysia (NRA, University of Miami) maintains large stocks of live animals and relies on regular shipments of wild-caught individuals to maintain genetic diversity. This is labor and cost-intensive, and environmental changes could alter the availability of wild animals increasing the need to preserve this genetic resource. One solution is vitrification, ultra-fast cooling which produces an amorphous glass that minimizes damage to cells. Aplysia californica presents …

Simulation Study Of A Novel Small Animal Flash Irradiator (Safi) With Integrated Inverse-Geometry Ct Based On Circularly Distributed Kv X-Ray Sources, Yuewen Tan, Shuang Zhou, Jonathan Haefner, Qinghao Chen, Thomas R Mazur, Arash Darafsheh, Tiezhi Zhang

2020-Current year OA Pubs

Ultra-high dose rate (UHDR) radiotherapy (RT) or FLASH-RT can potentially reduce normal tissue toxicity. A small animal irradiator that can deliver FLASH-RT treatments similar to clinical RT treatments is needed for pre-clinical studies of FLASH-RT. We designed and simulated a novel small animal FLASH irradiator (SAFI) based on distributed x-ray source technology. The SAFI system comprises a distributed x-ray source with 51 focal spots equally distributed on a 20 cm diameter ring, which are used for both FLASH-RT and onboard micro-CT imaging. Monte Carlo simulation was performed to estimate the dosimetric characteristics of the SAFI treatment beams. The maximum dose …

Multi-Site Identification And Generalization Of Clusters Of Walking Behaviors In Individuals With Chronic Stroke And Neurotypical Controls, Natalia Sanchez, Nicolas Schweighofer, Sara J. Mulroy, Ryan T. Roemmich, Tricia M. Kesar, Gelsy Torres-Oviedo, Beth E. Fisher, James M. Finley, Carolee J. Winstein

Physical Therapy Faculty Articles and Research

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Objectives

Methods

Rbfox2 Regulated Eya3 Isoforms Partner With Six4 Or Zbtb1 To Control Transcription During Myogenesis, Hannah J Wiedner, R Eric Blue, Matheus Sadovsky, C Allie Mills, Xander H T Wehrens, Laura E Herring, Jimena Giudice

Faculty, Staff and Students Publications

Alternative splicing is a prevalent gene-regulatory mechanism, with over 95% of multi-exon human genes estimated to be alternatively spliced. Here, we describe a tissue-specific, developmentally regulated, highly conserved, and disease-associated alternative splicing event in exon 7 of the eyes absent homolog 3 (Eya3) gene. We discovered that EYA3 expression is vital to the proliferation and differentiation of myoblasts. Genome-wide transcriptomic analysis and mass spectrometry-based proteomic studies identified SIX homeobox 4 (SIX4) and zinc finger and BTB-domain containing 1 (ZBTB1), as major transcription factors that interact with EYA3 to dictate gene expression. EYA3 isoforms differentially regulate transcription, indicating that …

Moving From Symptom Management To Upstream Plastics Prevention: The Fallacy Of Plastic Cleanup Technology, Melanie Bergmann, Hans Peter H. Arp, Bethanie Carney Almroth, Win Cowger, Marcus Eriksen, Tridibesh Dey, Sedat Gündoğdu, Rebecca R. Helm, Anja Krieger, Kristian Syberg, Mine B. Tekman, Richard C. Thompson, Patricia Villarrubia-Gómez, Anish Kumar Warrier, Trisia Farrelly

School of Biological and Marine Sciences

Plastic removal technologies can temporarily mitigate plastic accumulation at local scales, but evidence-based criteria are needed in policies to ensure that they are feasible and that ecological benefits outweigh the costs. To reduce plastic pollution efficiently and economically, policy should prioritize regulating and reducing upstream production rather than downstream pollution cleanup.

Advancing Research Visibility Through Collections: A Case Study From Nursing, Travis Nace

Medical Institutional Repositories in Libraries (MIRL)

Temple University Libraries' scholarly repository, TUScholarShare, began in 2020 and is a relatively young scholarly repository with growth potential in many subject areas. Travis Nace, the nursing liaison librarian, noticed an area for potential growth: nursing-produced posters were noticeably absent from the repository. No specific community or sub-community (collections) were focused on nursing research and scholarly publications despite much being produced at Temple University.

In the spring of 2022 discussion began to create a nursing specific community. Talks were scheduled with Temple University Hospital nurse educators to obtain posters presented between 2015 and 2020. These were seen as a good …

Hca Healthcare Scholarly Commons: Assembling A Knowledge Menagerie, Lindsay Million

Medical Institutional Repositories in Libraries (MIRL)

HCA Healthcare Scholarly Commons is the institutional repository for HCA Healthcare Graduate Medical Education programs. Utilizing the bepress Digital Commons platform, our repository houses scholarly works from over 300 residency and fellowship programs at 66 teaching hospitals nationwide. During the presentation, the institutional repository manager will discuss using Scholarly Commons to create traditional collections and various writing education and scholarly activity initiatives housed in the repository. Collections discussed will include:

1. The Write Way: A Peer Review Panel "This is an online peer-review platform for HCA Healthcare GME residents, fellows, and faculty; participants can serve as a reviewer and/or submit …

Publishing Medical Student Capstone Research In Your Institutional Repository: Challenges And Opportunities For Scholarly Publishing Instruction, Marlowe Bogino, Benjamin Saracco

Medical Institutional Repositories in Libraries (MIRL)

The Cooper Medical School of Rowan University has a unique, required four-year curriculum and course named Scholar's Workshop. The Scholars Workshop course addresses biostatistics, epidemiology, quality and patient safety, health care disparities, research, research ethics, and other related topics. A primary assignment on this course is the creation of culminating capstone projects completed in the M3 and M4 years which include a written a thesis and poster presentation under the guidance of a clinical mentor. Rowan University medical librarians began a new service that allows medical students the option of publishing their capstone project materials into the library's institutional repository …

Finding The Golden Mean: An Efficient Model For Improving Discovery And Access For Legacy Theses And Dissertations In A Medical Library’S Institutional Repository, Brandon Pieczko

Medical Institutional Repositories in Libraries (MIRL)

Developing an efficient and cost-effective method for providing access to legacy print theses and dissertations is a challenge faced by many libraries that serve medical schools and other academic health science programs. The significant staff time and financial cost associated with systematically digitizing and providing complete online access to print theses and dissertations can be problematic given the potentially limited return on that investment as reflected in patron use statistics and other metrics. This presentation will describe how a medical school library improved the discoverability and accessibility of its legacy print theses and dissertations by implementing a cost-effective, selective digitization …

Vol. 60 No. 2 - Whole No. 405, Megan Abrahamson

Mythprint

Mythprint is the quarterly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local discussion groups.

Vol. 59 No. 4 - Whole No. 403, Megan Abrahamson

Mythprint

Mythprint is the quarterly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local discussion groups.

Vol. 59 No. 3 - Whole No. 402, Megan Abrahamson

Mythprint

Mythprint is the quarterly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local discussion groups.

Care Data Principles Data Curation Primer, Katie Pierce Farrier, Sarah Barsness, Maria Victoria Fernandez, Alex Wieker, Ann Myatt James

Medical Institutional Repositories in Libraries (MIRL)

The CARE data principles (Collective benefit, Authority to control, Responsibility, and Ethics) are a conceptual framework meant to ensure ethical collection, sharing, and stewardship of Indigenous data. As part of a workshop hosted by the Data Curation Network in 2022, librarians created a foundational data curation primer on the CARE data principles and how they apply to data management, curation, and sharing. The primer touches on the cultural context regarding the CARE data principles, the historical misuse of Indigenous data, tribal sovereignty, and Indigenous Peoples' right to governance of their data. This session will discuss how CARE principles can be …

Slump: Find Funding And New Friends In A Bad Year, Dina Mckelvy

Medical Institutional Repositories in Libraries (MIRL)

The MaineHealth Library has funded its repository with crumbs for several years. 2023 was supposed to be the year to create a permanent repository staff position. In a severely challenging financial year, we used supportive data and created new partnerships to find sweet success.

Knowledge Syntheses Search Strategy Repositories: Canadian Case Studies, Heather Cunningham, Sabine Calleja, Julia Martyniuk, Daniela Ziegler, Alix Pincivy, Jill Boruff, Alisa Rod

Medical Institutional Repositories in Libraries (MIRL)

Knowledge synthesis research is central to evidence-based medicine. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses literature search extension (PRISMA-S) outlines full reporting of the search strategy component including uploading documentation of all search strategies into a data repository to increase accessibility, transparency, and reproducibility. In response to the PRISMA-S recommendations, Canadian universities and health care institutions have been increasingly offering local services for librarians to support depositing and sharing search strategies in a digital data repository on the Borealis platform. Borealis, the Canadian Dataverse Repository, is a bilingual, multidisciplinary, secure, Canadian research data repository which supports open discovery, …

Getting Creative: Implementing "Fan Favorite" Voting In Digital Commons Event, Jennifer Deal, Elizabeth Suelzer

Medical Institutional Repositories in Libraries (MIRL)

Problem/Scenario: The coordinators of our institution's 2023 Scientific Day event wanted to allow attendees to cast votes for a new Fan Favorite poster award and they asked library staff for help in making this possible. Library staff maintain the institutional repository (IR) for our large health care system, and posters from Scientific Day are deposited in the IR so they are visible to judges and attendees during the virtual event. Our Digital Commons IR did not have a built-in voting system, so library staff used Springshare's LibWizard and our HTML and design skills to add "Like" buttons to conference posters …

Nlm Scrubber To De-Identify Clinical Text Data And Facilitate Data Sharing, Christine Nieman Hislop, Katie Pierce-Farrier

Medical Institutional Repositories in Libraries (MIRL)

Before sharing clinical data, personal and sensitive information must be removed or de-identified. The NLM Scrubber is a clinical text de-identification tool developed by the National Library of Medicine. This session will give a brief introduction to different branches of AI. Natural language processing (NLP) is one such branch of AI that combines linguistics and computer science to make human language understandable to computers. The NLM Scrubber uses NLP to identify personally identifying information and replace it with generic terms. It is a freely available tool that can be customized to look for and redact specific terms and phrases. NLM …

How To Showcase And Preserve The History Of A Medical Library Using The Tmc Library's Digital Commons Exhibits, Alice Sherwood

Medical Institutional Repositories in Libraries (MIRL)

How can you engage users with the history of your medical library? The TMC Library has a rich history that started in 1915, while Texas Medical Center started in the early 1940s. The TMC Library, which also has a historical center that regularly showcases archival materials using exhibits at library public spaces, started exploring additional options reaching out to a wider audience to view these exhibit materials since November 2022. With the TMC Library started using Digital Commons in 2005 with close to 1.85 million total downloads to this date, using other features of Digital Commons becomes logical choice. From …

Expansionary Fiscal Contraction Hypothesis: An Evidence From Pakistan, Aisha Irum

CBER Conference

The fiscal sector in Pakistan has been facing mule-layered challenges over several years. One of the reasons is the stubborn and unproductive nature of its public expenditure, and the other one is the lower tax revenues. This issue of hovering fiscal deficit is mostly dealt with the tools of fiscal contraction/austerity which can have a potential impact on the private sector of the economy. Thus, the question which has been addressed in this study is whether the Expansionary Fiscal Contraction (EFC) hypothesis holds in case of Pakistan. Fiscal contraction episodes have been identified using growth in the growth rates of …

Relationship Between Human Capital And Urban Growth, Lucky Bizenjo

CBER Conference

This study has provided new insights into the relationship between urbanization and human capital, made its implications at the global income group level and national level. In the first study, panel data of 87 countries used from 1991 to 2019. The results showed that education is found to be negatively and insignificantly associated with urbanization at the global level, but it is found to be positive (though insignificant) in low-income countries, and positive and significant in low-income countries and middle-income countries, and high-income countries. Our research suggests that as the income of a country increases, the contribution of education to …

Modifying Koha To Use As A Local Authors' Catalog, Fred King

Medical Institutional Repositories in Libraries (MIRL)

Koha is a widely-used Integrated Library System, free to download, free to use. It is open-source software, is infinitely configurable and can be used in a variety of ways. This presentation will show how MedStar Washington Hospital Center is using Koha and modified Medline records to track articles written by MedStar authors.

Cleaning-Up And Marketing Ohsu Digital Collections, Pamela Pierce, Marijane White

Medical Institutional Repositories in Libraries (MIRL)

"Cleaning-up and Marketing OHSU Digital Collections" focuses on the metadata clean-up and marketing of our new Tind digital collection platform. This lightning talk will highlight the work we did in OpenRefine to be able to have newly cleaned records to show people, increasing deposits. We will also share our communication plan which focuses on the following audiences: general students, faculty/program directors, researchers/research mission/, clinicians, and postdocs. Continuing conversations started at the earlier phase of implementation is essential to a successful marketing plan.

Pure-Ly For Authors: An Update Of A Health System Researcher Profile Platform, Heather J. Martin, Amanda Schwartz

Medical Institutional Repositories in Libraries (MIRL)

In 2023, a large healthcare system transitioned their institutional repository's author profile service to an upgraded and more comprehensive platform, and in doing so re-energized author and leadership buy-in.

After Digital Commons'™ Expert Gallery Suite eliminated some functionality, institutional repository (IR) staff began the process of exploring other author profile platforms that would align with essential workflows. Elsevier's™ Pure rose to the top of compatible and robust platforms suitable to replace our previous solution.

Pure's™ automated importing and database-integration was a primary draw, but IR staff had to find creative ways to utilize the administrative features that didn't integrate with …

Vol. 59 No. 2 - Whole No. 401, Megan Abrahamson

Mythprint

Mythprint is the quarterly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local discussion groups.

Risalud-Andalucia, The Institutional Repository Of The Public Health System Of Andalusia, Laura Muñoz-Gonzalez, Victoria Barragan-Roman, Eva Toro-Periñan, Juan Antonio Hernandez-Morales

Medical Institutional Repositories in Libraries (MIRL)

Introduction: The Andalusian Public Health System is made up of a public care network that has 63 hospitals, 1,500 primary care centers, 5 health research institutes, and other non-care public entities, mainly management and training institutions. RISalud-ANDALUCIA, the Institutional Repository of the Andalusian Public Health System is a unique and open space where the intellectual and scientific production generated by the professionals of the Andalusian Public Health System is gathered, as a result of their assistance, research and management activity.

Objective: Development of a new version of RISalud-ANDALUCIA which implies a new software upgrade and functional improvement. Methodology RISalud-ANDALUCIA, was …

Paroxysmal Atrial Fibrillation In A Life-Long Endurance Athlete: A Descriptive Case Study, Timothy Curry, Scott N. Drum

International Journal of Exercise Science: Conference Proceedings

The diagnosis of atrial fibrillation (AF) in lifelong endurance athletes occurs at a greater incidence over a lifetime vs the undertrained, general population. In fact, the more intense an aerobic-oriented person trains or races and over a greater amount of time, the higher the diagnosis of general cardiac arrhythmias. PURPOSE: Therefore, the primary aim was to observe the cumulative effects of life-long endurance training (since the age of 10-yrs old) and the yearly occurrences of paroxysmal AF (PAF) in an otherwise healthy, 53-yr-old male. METHODS: The complete health history of a 53-yr-old male (ht: 1.83 m, wt: 72.7 kg, …

The Effectiveness Of Running Power As A Metric Of Exercise Intensity During Running Interval Training, Eric A. Lambert, Dustin W. Davis, Matahn Blank, Tashari A. Carballo, Elias M. Malek, Kathryn Lei A. Lavin, Thea Sweder, Nicole Argueta, Marcus M. Lawrence, James W. Navalta, Jeffrey Cowley

International Journal of Exercise Science: Conference Proceedings

Wearable power meters are increasingly popular among runners with Coros and Stryd offering running power as a real-time, trackable of a metric. PURPOSE: This study compared running power (RP) to physiological measures, heart rate (HR) and oxygen consumption (VO₂), across high and low intensity running intervals. METHODS: Thirteen adult participants (n = 6 male; height = 174.9 ± 6.9 cm; mass = 72.5 ± 12.0 kg) were equipped with a Stryd 27 RP meter, a Polar H10 HR monitor, and a Cosmed K5 portable metabolic unit. Participants’ self-selected RP was obtained during a 10-min run on …