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Correlation Of Thyroid Stimulating Hormone (Tsh), T3, And T4 Hormones With Histopathological Characteristics Of Thyroid Cancer At Cipto Mangunkusumo General Hospital, Ahmad Kurnia, Kristaninta Bangun, Fatahillah Muazdhani

The New Ropanasuri Journal of Surgery

Introduction. In a study spanning 2008 to 2012 at Cipto Mangunkusumo General Hospital (CMGH) Jakarta, 668 cases of thyroid cancer were identified among 18,216 cancer cases. Globally, the papillary subtype is prevalent, and prior research indicates a link between thyroid hormone changes and thyroid carcinoma risk. To improve surgical care, this study aims to find the association between thyroid hormone levels and histological subtypes in thyroid carcinoma patients.

Method. This cross-sectional study focused on thyroid cancer patients managed from 2013 to 2017. Despite subjects' characteristics, thyroid hormone levels and histopathological findings were the variables of interest. The findings were analyzed …

D-Dimer And Ultrasonography As The Early-Diagnostic Tools For Lower-Limb Trauma Patients With Deep Vein Thrombosis: A Literature Review, Faranita Muchtar, Akhmadu Muradi

The New Ropanasuri Journal of Surgery

Introduction. The mortality of venous thromboembolism increased among trauma patients. Both the D-dimer test and ultrasonography are selected to diagnose venous thromboembolism due to non-traumatic causes but are rarely utilized in emergency trauma settings.

Objectives. This literature review comprehensively explains the accuracy of the D-dimer test and ultrasonography for deep vein thrombosis (DVT) diagnosis. This study finding might broaden the diagnostic recommendation for traumatic patients with deep vein thrombosis.

Method. This study used articles from four distinct journal databases. Only eight of the 480 articles found during searching proceeded with the screening process. Thus, five articles were included …

Neutrophil-Lymphocyte-Ratio As Predictor Of Morbidity And Mortality In Adults With Gastrointestinal Obstruction, Agi S. Putranto, Bimo D. Pramesta

The New Ropanasuri Journal of Surgery

Introduction. Gastrointestinal (GI) obstruction is a condition that often requires surgery and can lead to severe complications. The neutrophil-to-lymphocyte ratio (NLR) has been used as an inflammation indicator in various medical conditions, but research on the relationship between NLR and GI obstruction is still limited. Therefore, this study aims to evaluate the role of NLR as a cost-effective and simple preoperative predictor of postoperative mortality and morbidity, mainly surgical site infection, in adult patients with GI obstruction.

Method. This cross-sectional study was conducted at Cipto Mangunkusumo General Hospital in Jakarta. The study sample consists of 150 adult patients with GI …

Preoperative Neutrophil–Lymphocyte Ratio And Serum Carcinoembryonic Antigen As Predictive Factors Of Colorectal Cancer Survival, Agi S. Putranto, Jackson Kamaruddin

The New Ropanasuri Journal of Surgery

Introduction. Colorectal cancer is the second leading cause of death worldwide, with a high mortality rate. This study investigates the predictive value of the neutrophil–lymphocyte ratio (NLR) and carcinoembryonic antigen (CEA) in predicting the survival rates of colorectal cancer patients in Indonesia.

Method. This retrospective cohort study enrolled the colorectal cancer stage I–IV patients treated at Cipto Mangunkusumo General Hospital (CMGH). The independent variables are NLR and CEA, while the dependent variable is the five–year survival of colorectal cancer. The log rank test proceeded to find a correlation between NLR and CEA with 5–year survival, and the Cox proportional hazard …

Factors Influencing Ulcer Healing In Chronic Limb Threatening Ischemia Patients After Endovascular Angioplasty At Cipto Mangunkusumo General Hospital, Raden Suhartono, Ghany H. Wijaya, Akhmadu Muradi

The New Ropanasuri Journal of Surgery

Introduction. Chronic limb–threatening ischemia (CLTI) can cause rest pain in the lower extremities and the formation of ulcers or gangrene. Revascularization, which can be done using open surgery or endovascular procedures, is the first line of treatment in CLTI management. CLTI patients at CMGH usually came with advanced conditions and high re–amputation rates even after revascularization. This study aimed to determine factors associated with the outcome of endovascular angioplasty, especially ulcer healing.

Method. A cross–sectional study was conducted at CMGH, enrolling CLTI patients with Rutherford grades 5 and 6 who underwent angioplasty. Age, gender, history of smoking, hypertension, atrial fibrillation, …

A Critical Policy Analysis Of Kentucky School Districts’ Trauma-Informed Education Plans, Tommy Wells, Alexandra J. Taylor, Amy Lein

Kentucky Teacher Education Journal: The Journal of the Teacher Education Division of the Kentucky Council for Exceptional Children

The Commonwealth of Kentucky has taken its first steps in creating trauma-informed K-12 schools through passing the School Safety and Resiliency Act of 2019. School districts were tasked with developing trauma-informed education plans by July 2021. However, the Commonwealth’s mandate gave broad autonomy to school districts in shaping their trauma-informed education plans’ processes and content. Through a critical policy analysis design, this study examined the availability and quality of trauma-informed education plans from each school district in Kentucky and compared them to the trauma-informed framework developed by the National Child Traumatic Stress Network. Findings indicate that only 19 out of …

Effect Of Influencers On The Intention To Taste Local Food And Beverages, Yeliz Demir, Serkan Bertan

Journal of Mediterranean Tourism Research

The study aims to determine the impact of influencers promoting local food and beverages on individuals’ intention to taste local food. In this study, Instagram accounts were selected as the social media platform. The research data were obtained from Turkish Instagram users over the age of 18 by using an online survey and purposive sampling method, and usable data were obtained from 81 people. Of the participants, 56.8% stated that they follow Instagram accounts related to gastronomy, and 43.2% stated that they do not follow these social media accounts but look at the photos and videos of gastronomy accounts when …

Career Transitioning Among Students With Visual Impairments: Educational And Public Policy Perspectives, Chiedu Eseadi, Shulamite E. Ogbuabor

Jurnal Kajian Bimbingan dan Konseling

The objective of this research is to examine the educational and public policy concerns pertaining to career transitioning among students with visual impair-ments. The authors conducted a narrative literature review. The conceptualization of policy, with a specific focus on educational and public policies, was provided. The article also discussed the roles and concerns of educational and public policies in facilitating career transitioning for these students. The study contributes to an increased understanding of the educational and policy implications of supporting students with visual impairments during career transitioning. The collaboration of career counsellors and policy actors is deemed necessary in order …

Deep Learning In Bioinformatics, Malik Yousef, Jens Allmer

Turkish Journal of Biology

Deep learning is a powerful machine learning technique that can learn from large amounts of data using multiple layers of artificial neural networks. This paper reviews some applications of deep learning in bioinformatics, a field that deals with analyzing and interpreting biological data. We first introduce the basic concepts of deep learning and then survey the recent advances and challenges of applying deep learning to various bioinformatics problems, such as genome sequencing, gene expression analysis, protein structure prediction, drug discovery, and disease diagnosis. We also discuss future directions and opportunities for deep learning in bioinformatics. We aim to provide an …

Who's Publishing What: The Weight We Carry, Erma Bombeck Writers' Workshop

Erma Bombeck Writers' Workshop Blog

Christina Consolino's newest novel, The Weight We Carry, "reminds us of the fine line between reliance and independence, tending and mothering, and love and obligation."

School Environment As Barrier To Effective Academic Performance Among Students With Physical Disabilities In Ilorin Metropolis, Florence Bosede Famolu

Jurnal Kajian Bimbingan dan Konseling

Insufficient infrastructural facilities make it difficult for a large number of students with visual and mobility impairment to walk around the campus and attend lectures. Also, fewer than ideal library facilities decrease the amount of study resources that are available to these students. This study investigated the school environment as barrier to effective academic performance among students with physical disabilities in the Ilorin metropolis, Kwara State. The descriptive survey of a correlational type was implemented using purposive sampling for this study. A purposive sampling technique was used to select 98 students in the Ilorin metropolis with physical disabilities, and the …

Measuring The Difficulties Of Early Adulthood: The Development Of The Quarter Life Crisis Scale, Muslim Afandi, Nail Hidaya Afandi, Syed Agung Afandi, Rizki Erdayani

Jurnal Kajian Bimbingan dan Konseling

This study was conducted to develop a quarter-life crisis scale that can be used to measure the quarter-life crisis of early adulthood in Indonesia. Although it has begun to become a concern for researchers in Indonesia, the development of the quarter-life crisis scale has never been created. Some researchers have adapted the constructs developed by foreign researchers, which are not necessarily suitable for applicated in Indonesia. The development of this scale goes through 5 stages: conceptualization of the test; test construction; test trial; item analysis; and test revision. The test trial was filled by 181 early adults in Indonesia from …

Congenital Cystic Adenomatoid Malformation Type-1 In Female Appropriate For Gestational Age Infant, Rishit Anand, Niharika Srivastava, Santosh Rai, Kochikar Anand Pai

Manipal Journal of Medical Sciences

Congenital Cystic Adenomatoid Malformation Type-I corresponds to respiratory distress and is a congenital lung condition linked to aberrant lung development brought on by lung tissue overgrowth that creates cysts in the lung lobes.

A 36-year-old female patient with uterine gestation of 24 weeks reported with thin-walled cystic lesion in left thoracic cavity displacing the cardia to right side which could have likely been CCAM Type-1. At 20th day of the delivery, CECT Chest was performed which reported well-defined round thin-walled unilocular cystic lesion in the apico posterior segment of left upper lobe with air-fluid level and compensatory hypertrophy of left …

Information Behavior And Hiv/Aids/Sti Awareness Among Bangladeshi Female Sex Workers: Do Informational Programs Help?, Nafiz Z. Shuva, Radia Taisir, Parvez Sazzad Mallick

Publications and Research

Using de Certeau's concepts of “tactics” and “strategies,” this study explores the everyday information seeking behavior of female sex workers (FSWs) in Bangladesh. This study also examined the effectiveness of informational programs on HIV/AIDS and STI in empowering FSWs to negotiate condom use during sex. A mixed method research design was employed in this study, which included face-to-face surveys with 116 female sex workers (FSWs) and four focus group discussions (FGDs) with 23 street based FSWs. The study finds that Bangladeshi female sex workers use “tactics” in meeting their information needs. They reported rarely using formal information sources such as …

Cover And Contents

Turkish Journal of Biology

No abstract provided.

Svm-Do: Identification Of Tumor-Discriminating Mrna Signatures Via Support Vectormachines Supported By Disease Ontology, Mustafa Erhan Özer, Pemra Özbek Sarica, Kazim Yalçin Arğa

Turkish Journal of Biology

Background/aim: The complicated nature of tumor formation makes it difficult to identify discriminatory genes. Recently, transcriptome-based supervised classification methods using support vector machines (SVMs) have become popular in this field. However, the inclusion of less significant variables in the construction of classification models can lead to misclassification. To improve model performance, feature selection methods such as enrichment analysis can be used to extract useful variable sets. The detection of genes that can discriminate between normal and tumor samples in the association of cancer and disease remains an area of limited information. We therefore aimed to discover novel and practical sets …

Compcorona: A Web Application For Comparative Transcriptome Analyses Ofcoronaviruses Reveals Sars-Cov-2-Specific Host Response, Rana Sali̇hoğlu, Fati̇h Saraçoğlu, Mustafa Si̇bai̇, Tali̇p Zengi̇n, Başak Abak Masud, Onur Karasoy, Tuğba Önal Süzek

Turkish Journal of Biology

Background/aim: Understanding the mechanism of host transcriptomic response to infection by the SARS-CoV-2 virus is crucial, especially for patients suffering from long-term effects of COVID-19, such as long COVID or pericarditis inflammation, potentially linked to side effects of the SARS-CoV-2 spike proteins. We conducted comprehensive transcriptome and enrichment analyses on lung and peripheral blood mononuclear cells (PBMCs) infected with SARS-CoV-2, as well as on SARS-CoV and MERS-CoV, to uncover shared pathways and elucidate their common disease progression and viral replication mechanisms. Materials and methods: We developed CompCorona, the first interactive online tool for visualizing gene response variance among the family …

Epilepsy Networks And Their Surgical Relevance, Kevin Hines, Chengyuan Wu

Department of Neurosurgery Faculty Papers

Surgical epilepsy is a rapidly evolved field. As the understanding and concepts of epilepsy shift towards a network disorder, surgical outcomes may shed light on numerous components of these systems. This review documents the evolution of the understanding of epilepsy networks and examines the data generated by resective, ablative, neuromodulation, and invasive monitoring surgeries in epilepsy patients. As these network tools are better integrated into epilepsy practice, they may eventually inform surgical decisions and improve clinical outcomes.

Maternal Western Diet Programs Cardiometabolic Dysfunction And Hypothalamic Inflammation Via Epigenetic Mechanisms Predominantly In The Male Offspring, Mona Elgazzaz, Clara Berdasco, Jone Garai, Melody Baddoo, Shiping Lu, Hisham Daoud, Jovanny Zabaleta, Franck Mauvais-Jarvis, Eric Lazartigues

School of Medicine Faculty Publications

Objective; Maternal exposure during pregnancy is a strong determinant of offspring health outcomes. Such exposure induces changes in the offspring epigenome resulting in gene expression and functional changes. In this study, we investigated the effect of maternal Western hypercaloric diet (HCD) programming during the perinatal period on neuronal plasticity and cardiometabolic health in adult offspring. Methods; C57BL/6J dams were fed HCD for 1 month prior to mating with regular diet (RD) sires and kept on the same diet throughout pregnancy and lactation. At weaning, offspring were maintained on either HCD or RD for 3 months resulting in 4 treatment groups …

Comparison Of Attitudes To Media Representation Of Mental Illness Between Journalists And Mental Health Professionals In Russia With German-Speaking Countries Of Switzerland, Germany, And Austria, Christiane Eichenberg, Lilian Strobl, Tina Jaeger, Alla Kirsha, Richard Laugharne, Rohit Shankar

Peninsula Medical School

Background: The media are an important source of information on mental health. They are often implicit in reinforcing negative stereotypes of people with mental health problems. There are no studies in German-speaking countries or Russia on media attitudes to mental health and mental health professionals’ (MHP) attitudes to the media. Aims: This study explored journalists and MHPs attitudes to mental health media reporting in the German speaking countries of Switzerland, Germany, and Austria and in Russia. Methods: A cross-sectional online internet survey, of ten Likert scale statements to ascertain perceptions of stigma, role, and training needs following the STROBE guidance …

Analysis Of Potentially Inappropriate Prescriptions (Pip) Based On Stopp/Start Criteria In Geriatric Patients With Cardiovascular Disorders At Hasan Sadikin Hospital, Bandung, West Java, Indonesia, Fathurrahmi Fathurrahmi, Gofarana Wilar, Jutti Levita, Rina Winarni

Pharmacology and Clinical Pharmacy Research

The geriatric population in Indonesia is increasing rapidly every year. The large number of drugs consumed by geriatric patients results in potentially inappropriate prescriptions (PIP) in the form of mis-prescribing drugs (potentially inappropriate medicines or PIM) and under-prescribing drugs (potentially prescription omission or PPO). In Indonesia, especially in Bandung, there is limited research on PIP in geriatric patients with cardiovascular disorders (CVDs). This study aims to identify PIP and factors that influence PIM and PPO based on STOPP/START criteria and the relationship between the incidence of PIM and kidney function in geriatric inpatients with CVDs at Hasan Sadikin Hospital, Bandung, …

Federal Court Blocks Enforcement Of Idaho’S Ban On Gender-Affirming Care For Minors, Arthur S. Leonard

Other Publications

No abstract provided.

Psychological Well-Being Of Pre-Service Training Teachers, Indriyana Rachmawati, Aprilia Tina Lidyasari

Jurnal Kajian Bimbingan dan Konseling

The recent statistic suggests the average psychological well-being of Indonesian citizens, including the pre-service training teacher, represents their capacity to overcome future challenges. Excellent psychological well-being is crucial for pre-service training teachers, especially for providing a comfortable learning situation for students and engaging in effective communication with students. This study investigates the psychological well-being of pre-service training teachers. Thus, this study adopted survey techniques with descriptive data analysis. The data were collected from 44 teachers selected by purposive sampling. The criteria for selecting research participants were currently taking pre-service teacher education, elementary school teachers, and willingness to participate in this …

Education And Work Future Expectation Scale Adaptation For Indonesian University Students, Ike Dwiastuti, Wiwin Hendriani, Fitri Andriani

Jurnal Kajian Bimbingan dan Konseling

The students' optimism about their future careers and education impacts their educational success. The Future Expectation Scale of Adolescents (FESA) can measure future expectations of education and student career. This study aims to adapt the scale of the FESA work and education domain to the Indonesian language and culture. The adaptation in this study follows the six-stage category of the International Commission Test. Development of adaptation items using a forward-backward translation design involving six experts. The comparability of language and content validity assessments involved nine experts. Pilot study for item evaluation involving 15 students from the target population. The quantitative …

Glp1 Receptor Agonists-Effects Beyond Obesity And Diabetes, Sydney S Wilbon, Mikhail G Kolonin

Faculty, Staff and Student Publications

Glucagon-like peptide-1 receptor agonists (GLP1RA) have been transformative for patients and clinicians in treating type-2 diabetes and obesity. Drugs of this class, the bioavailability of which is continuously improving, enable weight loss and control blood glucose with minimal unwanted side effects. Since adopting GLP1RA for treating metabolic diseases, animal and clinical studies have revealed their beneficial effects on several other pathologies, including cardiovascular diseases, neurodegeneration, kidney disease, and cancer. A notable commonality between these diseases is their association with older age. Clinical trials and preclinical data suggest that GLP1RA may improve outcomes in these aging-related diseases. Some of the benefits …

Patient-Reported Sexual Function, Bladder Function And Quality Of Life For Patients With Low Rectal Cancers With Or Without A Permanent Ostomy, Michael K Rooney, Melisa Pasli, George J Chang, Prajnan Das, Eugene J Koay, Albert C Koong, Ethan B Ludmir, Bruce D Minsky, Sonal S Noticewala, Oliver Peacock, Grace L Smith, Emma B Holliday

Faculty, Staff and Student Publications

BACKGROUND: Despite the increasing utilization of sphincter and/or organ-preservation treatment strategies, many patients with low-lying rectal cancers require abdominoperineal resection (APR), leading to permanent ostomy. Here, we aimed to characterize overall, sexual-, and bladder-related patient-reported quality of life (QOL) for individuals with low rectal cancers. We additionally aimed to explore potential differences in patient-reported outcomes between patients with and without a permanent ostomy.

METHODS: We distributed a comprehensive survey consisting of various patient-reported outcome measures, including the FACT-G7 survey, ICIQ MLUTS/FLUTS, IIEF-5/FSFI, and a specific questionnaire for ostomy patients. Descriptive statistics and univariate comparisons were used to compared demographics, treatments, …

Social Determinants Of Health And Disparities In Hypertension And Cardiovascular Diseases, Abhishek Chaturvedi, Anqi Zhu, Naga Vaishnav Gadela, Dorairaj Prabhakaran, Tazeen Jafar

Department of Medicine

High blood pressure causes over 10 million preventable deaths annually globally. Populations in low- and middle-income countries suffer the most, experiencing increased uncontrolled blood pressure and cardiovascular disease (CVD) deaths. Despite improvements in high-income countries, disparities persist, notably in the United States, where Black individuals face up to 4× higher CVD mortality than White individuals. Social determinants of health encompass complex, multidimensional factors linked to an individual's birthplace, upbringing, activities, residence, workplaces, socioeconomic and environmental structures, and significantly affect health outcomes, including hypertension and CVD. This review explored how social determinants of health drive disparities in hypertension and related CVD …

Amondys 45 (Casimersen), A Novel Antisense Phosphorodiamidate Morpholino Oligomer: Clinical Considerations For Treatment In Duchenne Muscular Dystrophy, Megan E. Vasterling, Rebecca J. Maitski, Brice A. Davis, Julie E. Barnes, Rucha A. Kelkar, Rachel J. Klapper, Hirni Patel, Shahab Ahmadzadeh, Sahar Shekoohi, Alan D. Kaye, Giustino Varrassi

School of Medicine Faculty Publications

AMONDYS 45 (casimersen) is an antisense oligonucleotide therapy used to treat Duchenne muscular dystrophy (DMD), a rare genetic disorder characterized by a mutation in the DMD gene. Symptoms include progressive muscle weakness, respiratory and cardiac complications, and premature death. Casimersen targets a specific mutation in the DMD gene that results in the absence of dystrophin protein, a key structural component of muscle fibers. While there is currently no cure for DMD, exon-skipping therapy works by restoring the reading frame of the mutated gene, allowing the production of a partially functional dystrophin protein. Clinical trials of casimersen have shown promising results …

Act-Enhanced Behavior Therapy For A Hispanic Adult With Trichotillomania: A Case Report, Marissa L. Donahue, Michael P. Twohig

Psychology Faculty Publications

Trichotillomania, also known as Hair-Pulling Disorder, is characterized by recurrent pulling out of one’s hair over brief episodes or sustained periods of time and results in hair loss. ACT-enhanced behavior therapy (A-EBT) has been shown to be an effective approach in the treatment of trichotillomania by promoting psychological flexibility around hair pulling urges and teaching stimulus control and habit reversal training. However, there is limited support of A-EBT for clients with an ethnic minority identity. This case report focuses on an adult, Hispanic female client, Luna (pseudonym), who received eight sessions of A-EBT for the treatment of trichotillomania. At post-treatment, …

Medical Student Advising During Virtual Residency Recruitment: Results Of A National Survey Of Internal Medicine Clerkship And Sub-Internship Directors, Irene Alexandraki, Nadia Ismail, Cindy J Lai, Nicholas S Duca, Temple Ratcliffe, Michael Kisielewski, Amber T Pincavage

Faculty, Staff and Students Publications

INTRODUCTION: The residency application process is a critical time for medical students. The COVID-19 pandemic prompted changes to the residency recruitment procedures with the conversion of interviews to a virtual format. For medical school advisors guiding students on an all-virtual residency application process brought uncertainty to their advising practices. Thus, this study aimed to identify advising practices during the 2021 virtual application cycle.

METHODS: We administered an IRB-exempt national survey through the Clerkship Directors in Internal Medicine to 186 internal medicine core/co-/associate/assistant clerkship directors and sub-internship directors representing 140 Liaison Committee on Medical Education-accredited U.S./U.S.-territory-based medical schools in spring 2021. …