Digital Commons Network^™

P53r245w Mutation Fuels Cancer Initiation And Metastases In Nash-Driven Liver Tumorigenesis, Denada Dibra, Mihai Gagea, Yuan Qi, Gilda P Chau, Xiaoping Su, Guillermina Lozano

Faculty, Staff and Student Publications

Obesity is a significant global health concern. Non-alcoholic fatty liver disease and non-alcoholic steatohepatitis (NASH) are common risk factors for hepatocellular carcinoma (HCC) and are closely associated with metabolic comorbidities, including obesity and diabetes. The TP53 tumor suppressor is the most frequently mutated gene in liver cancers, with half of these alterations being missense mutations. These mutations produce highly abundant proteins in cancer cells which have both inhibitory effects on wildtype (WT) p53, and gain-of-function (GOF) activities that contribute to tumor progression. A Western diet increases p53 activity in the liver. To elucidate the functional consequences of Trp53 mutations in …

Corporate Finance, Kenneth S. Bigel

Open Touro Created

2023

Corporate Finance is a comprehensive guide covering the three fundamental topics in Corporate Finance, including Capital Budgeting under Certainty, Capital Structure Theory, and Short-term Financial Management and Operating Leverage. In-depth explanations of topics and terms are provided as well as key illustration in the manner of problem sets and solutions, tables, and diagrams. Review problems are also included so that students can conduct self-assessments. This text will be continually updated in order to provide novel information and enhance students’ experiences.

An Evaluation Of Online Training Effectiveness And Pre-Service And In-Service Teacher Satisfaction: A Case Study From Nigeria, Laila Mohebi, Alanood Alshamsi, Mariam Alhammadi, Fatima Almohsen

All Works

This study evaluates the perceptions of 122 pre-service and in-service Nigerian teachers on adopting an online training module during the COVID-19 pandemic, a period marked by significant educational challenges and shifts. Employing a qualitative approach through open-ended online questions, it delves into the factors critical to enhancing online training effectiveness. Key findings highlight the importance of training in imparting theoretical knowledge and practical skills, the quality and relevance of content, interactivity, practical examples, and appropriate video length. These align with existing literature, underscoring the effectiveness of online training in challenging times. Significantly, nearly all participants expressed satisfaction with the training. …

Recovery Of Cirl Bunting, Emberiza Cirlus, Song Diversity After Translocation, Sa Collins, S Croft, C Jeffs, S Brown, Sr De Kort

School of Biological and Marine Sciences

In order to improve conservation outcomes translocation or reintroduction of individuals may be necessary. When song learning birds are translocated, changes in the cultural diversity of song repertoires, or abnormal vocalizations, in the new population can be a problem. We monitored song production over 8 years in a reintroduced population of the cirl bunting (Emberiza cirlus). Chicks were removed from nests in Devon, UK, between 2006 and 2011, translocated at 6 days old to be hand-reared and released in Cornwall, UK. Recordings at the release site in 2011 showed a significantly reduced population repertoire and individuals sang abnormal song types …

Triobp Modulates Β-Catenin Signaling By Regulation Of Mir-29b In Idiopathic Pulmonary Fibrosis, Lan Wang, Wenyu Zhao, Cong Xia, Shuaichen Ma, Zhongzheng Li, Ningdan Wang, Linke Ding, Yaxuan Wang, Lianhui Cheng, Huibing Liu, Juntang Yang, Yajun Li, Ivan Rosas, Guoying Yu

Faculty, Staff and Students Publications

Idiopathic pulmonary fibrosis (IPF) is a fatal and devastating lung disease of unknown etiology, described as the result of multiple cycles of epithelial cell injury and fibroblast activation. Despite this impressive increase in understanding, a therapy that reverses this form of fibrosis remains elusive. In our previous study, we found that miR-29b has a therapeutic effect on pulmonary fibrosis. However, its anti-fibrotic mechanism is not yet clear. Recently, our study identified that F-Actin Binding Protein (TRIOBP) is one of the target genes of miR-29b and found that deficiency of TRIOBP increases resistance to lung fibrosis in vivo. TRIOBP knockdown inhibited …

Renal Abscess Drainage Using A Novel Transgastric Endoscopic Approach: A Case Report, Abby Wojtas, Kevin Kunitsky, Chase Cavayero, Augustine Salami

Student Publications

Renal and perinephric abscesses are rare purulent infections within or around renal parenchyma, typically treated with antibiotics or various procedural approaches depending on abscess size. In this case report, we describe the novel use of a transgastric endoscopic ultrasound (EUS)-guided technique with placement of a stent for drainage between a renal abscess and the stomach in a patient who had failed attempted percutaneous drainage twice and where an open surgical approach was deemed inappropriate. The patient presented with a chief complaint of left flank pain, with CT revealing a ~4 x 4 cm renal abscess in the upper pole of …

Chronic Hepatitis B: A Summarized Anecdote Of Complexities In Natural History, Treatment, And Complications, Nicholas Noverati, Jay W. Jun, Vivan Yan, Dina Halegoua-De Marzio, Hie-Won Hann

Division of Gastroenterology and Hepatology Faculty Papers

Chronic hepatitis B is still a disease process that affects millions around the world. Serologies used to diagnose and follow the progression (or resolution) of the disease can be confusing for clinicians. Further, throughout years of treatment, there may be nuances in presentation that complicate management even further. In this short communication, we highlight six themes in response to treatment and outcomes, including complications. We have the unique perspective of following many patients over extended periods of time at our institution, which has brought these themes to life in order that they can be shared with other clinicians who may …

Faux Feminism In A Capitalistic Fever Dream: A Review Of Greta Gerwig's Barbie (2023), Amy La Porte, Lena Cavusoglu

Markets, Globalization & Development Review

Somewhere between meaningful discourse about female agency and the commercial interests of a problematic doll franchise lies Mattel's box office hit film Barbie, directed by Greta Gerwig. In a script-flipping interpretation of the real-world patriarchy, it catapults itself into overdue discussions about gender norms, objectification, and the pursuit of Westernized beauty ideals. While it may have introduced liberationist theories to a new generation of women, ultimately it is a film bound by cognitive dissonance. This paper will delve into the profit-making protagonist at the center of its story and argue the film's underlying incompatibility with diversity, feminism, and social …

Whither India’S Development: Toward Being A Super Power Or A Super Civilization?, Pradip Khandwalla

Markets, Globalization & Development Review

This commentary was triggered by my reading a lecture delivered by Saurabh Kumar, a former student of mine at Indian Institute of Management, who later served as India’s ambassador in various countries and international bodies. He bemoaned that China had much greater status in global affairs than India. Many others in India hanker for a super power status for India. I find this concern to be somewhat misguided. India should be aiming to be a great civilization, rather than a domineering superpower. The record of all the superpowers till now has been quite spotty in humane terms. My vision for …

The Coveted ‘Developed’ Imprimatur: Twenty-First Century Prospects And Cultural Crosscurrents, Nikhilesh Dholakia, Deniz Atik

Markets, Globalization & Development Review

No abstract provided.

Contract, Status And The Bonds Of Welfare, Kenneth Veitch

Emancipations: A Journal of Critical Social Analysis

This article explores the relationship between contract and status in the context of contemporary social policy. Using examples of contract in the areas of unemployment policy (what is here called the workfare contract) and what has become known as the financialisation of the welfare state (Social Impact Bonds), the article identifies the types of bonds and obligations involved in those contracts and their sources. Drawing critically on Émile Durkheim and Max Weber’s work on the history and pre-history of contract, it is argued that issues of status – the status of the unemployed and capital, amongst others – lie at …

Shaping A Crisis, Constructing Addiction: Discursive Depoliticization Of British Columbia’S Drug Policy, Hope Robinson

Emancipations: A Journal of Critical Social Analysis

This analysis sets out to inquire why the comprehensive public health response to the alarming surge in illicit opioid and stimulant-related fatalities in the Canadian province of British Columbia has not yielded the intended results, despite its forward-thinking policies grounded in a concern for health over criminalization (Govt of BC, 2016; Burton et al., 2021). I will claim that this purportedly progressive approach to public health has been ineffective because it fails to address the socio-political drivers of the overdose crisis. Relating the work of cultural anthropologist Philippe Bourgois on drug use as a coping mechanism and Carol Bacchi’s ontopolitical …

Brand Activism And Democratic Legitimacy: Exploring Pitfalls Through A Habermasian Analysis, Roxan Degeyter

Emancipations: A Journal of Critical Social Analysis

Brand activism has emerged as a prominent practice among corporations, as they publicly take a stand on contentious socio-political issues such as gender inequality, climate change, or discrimination, often through advertising. While extensive research has been conducted on the impact of brand activism as a marketing tool, examining its effects on sales, brand image, consumer attitudes, and authenticity, only a limited number of studies have studied its influence on public debate and processes of democratic legitimation. The latter have portrayed brand activism as an empowering force for the supported social movements, the public sphere, and democratic legitimacy, largely ignoring the …

Qic-Wd Teaming Guidance, Quality Improvement Center For Workforce Development (Qic-Wd)

Other QIC-WD Products

QIC-WD Teaming Structure

Overview

As you begin to plan for the first QIC-WD on-site meeting, the QIC-WD WIE team would like you to think about the site’s teaming structure. The development of the site’s governance/teaming structure will occur over time, evolving to meet the changing needs of the initiative. The QIC-WD WIE team will work with the sites to ensure the development of teaming structures that support the work of the initiative.

Characteristics of Effective Teams

Effective teams share the following common characteristics:

• Have passion for and commitment to the initiative
• Have clarity of each team members’ roles and responsibilities …

Collaborating To Conduct A Child Welfare Workforce Needs Assessment And Select An Intervention, Quality Improvement Center For Workforce Development (Qic-Wd)

Other QIC-WD Products

OVERVIEW OF EXPLORATION PHASE

The QIC-WD Continuous Workforce Development Process includes four major phases: Exploration, Installation, Initial Implementation, and Full Implementation . The goal of the Exploration phase is to identify and plan for implementation of a workforce strategy to find and/or keep good employees. This document provides supplemental guidance to the materials available through the Permanency Innovations Initiative, with adaptations for workforce applications. Steps 1–6 below are covered here.

Steps of Exploration Phase

1. Identify the problem we want to solve and what outcome(s) we want to target
2. Identify the population we intend to target
3. Identify potential causes of workforce …

Quality Improvement In Healthcare: A Practical Guide For Providers (Part 2), Jeremy Ellis

Transformative Medicine

No abstract provided.

Respiratory Syncytial Virus Vaccines For Adults, Maley Zents, Emily Wagner, Mary Hoang, Christina Swiger

Transformative Medicine

Respiratory syncytial virus (RSV) is a virus that causes outbreaks of acute lower respiratory tract infections (LRTI) worldwide. The infections are associated with high rates of hospitalizations, which may lead to death, especially in older adults and young children. Due to the morbidity and mortality associated with RSV, pharmaceutical companies have dedicated research to create a vaccine since the 1960s. Despite setbacks after the failure of the first RSV vaccine, new developments in research have led to the approval of two new vaccines. Ensuring healthcare professionals and patients are well-informed about these vaccines is crucial for facilitating informed, collaborative clinical …

“What Should I Do About This New Left Bundle Branch Block?”, Muhammad Asad Hanif, Muhammad Mohsin Zafar, Aniruddha Singh

Transformative Medicine

No abstract provided.

Impact Of Adding Reduced And Weight-Based Insulin Dosing Options To The Emergency Department And Inpatient Hyperkalemia Order-Set, Elaina Lioudis Pharmd, Bs, Regine Ghoubrial-Waibel Pharmd, Micah Kidd Msn, Rn, Agcns-Bc, Cmsrn

Transformative Medicine

Purpose: To compare the effects of weight-based, reduced, and standard IV insulin doses on potassium reduction and hypoglycemia incidence in the treatment of acute hyperkalemia.

Methods: The hyperkalemia treatment order-set was updated to include reduced and weight-based insulin dose options. Patients ≥ 18 years old with acute hyperkalemia treated with insulin using the order-set were included. Patients with missing data or who started dialysis before follow-up potassium monitoring were excluded. The primary efficacy outcome was reduction in serum potassium. The primary safety outcome was incidence of hypoglycemia and severe hypoglycemia. Secondary outcomes included insulin dose administered, completion of …

Hoffmann Sign, Anthony A. Donato Jr, Chinedu Ezikanyi

Transformative Medicine

The Hoffmann sign or reflex is commonly taught as part of the physical examination to detect abstract upper motor neuron pathology. We present a case of a patient with congenital spinal stenosis and a fall who had a positive Hoffmann sign as the result of a central cord syndrome. The materials contain a video of this physical exam finding and briefly review its history, reliability and clinical utility.

Microgreens Nutrition Outreach: A Novel Tool For Community-Wide Dietary Disease Prevention, Rayna Marshall, Jessica Nwabeke, Benjamin S. Haslund-Gourley, Cynthia Huang, Talmadge Gaither, Vibhuti Mishra, Sophia Kim, Hannah Xu, Faith Kean, Neiki Rokni, Annette Gadegbeku

Transformative Medicine

Purpose: To investigate how microgreens educational programming impacts the relationship between nutrition attitudes and healthy eating habits. Methods: A three-part workshop in Philadelphia, PA that consisted of a pre-survey, presentation, and microgreens kit assembly session was held. A post-survey was distributed electronically 1 week after the event. Results: 9 participants voluntarily attended the workshop and completed the pre-survey, and one-third of the participants submitted post-survey feedback. Participants were middle-aged, Black women from the Allegheny West neighborhood of Philadelphia, a predominantly (97.5%) Black neighborhood. The survey showed microgreens were well-received and suited for urban communities with little space and cold weather. …

Adolescent Bariatric Surgery Programs: Progress In Pennsylvania, Gunnar Wolfe Md, Lisa Baro Msn, Vesta Salehi Md, Renee Riddle, Stephan R. Myers

Transformative Medicine

Objective: In 2019 the American Academy of Pediatrics (AAP) called for increased access to Metabolic and Bariatric Surgery (MBS). To understand adolescent weight loss programs offering MBS in Pennsylvania, a survey was completed.

Methods: Adolescent weight loss centers in Pennsylvania offering MBS were identified using the American Society for Metabolic and Bariatric Surgery (ASMBS) on-line directory and Google search. Phone interviews were conducted with the director of each program.

Results: Eight programs were identified. Operations were performed in seven adult hospitals. Six had Comprehensive Adolescent Accreditation through the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP). A total …

Climate Monitoring In The Caumont Cave And Quarry System (Northern France) Reveal Near Oxygen Isotopic Equilibrium Conditions For Carbonate Deposition, Ingrid Bejarano-Arias, Carole Nehme, Sebastian Breitenbach, Hanno Meyer, Sevasti Modestou, Damase Mouralis

International Journal of Speleology

The study of modern cave deposits forming under near isotopic equilibrium conditions can potentially help disentangle the processes influencing the oxygen isotope system and suitability of stalagmites as archives of past hydrological or thermal changes. We used cave monitoring to evaluate the impact of kinetic isotope fractionation and assess the conditions under which modern cave carbonates form in the Caumont cave and quarry system, located in Normandy, northwest France. Over 20 months, we collected climatological data, dripwater, and modern carbonate samples at 2–4-week intervals at three different stations inside the Caumont cave and quarry system. We find highly stable (10.4 …

The Evaluation Of Successful Implementation Of Human Resource Information In Private Organization, Sancoko Sancoko, Armeyta Widya Oryza, Niko Grataridarga

Jurnal Administrasi Bisnis Terapan

This study intend to evaluate the use of the Human Resources Information System (HRIS) in private organization. User satisfaction is one of the conditions for the successful implementation of information systems. To evaluate this system information, the author uses the conceptual Delone and Mclean information system success model(ISSM). This study employs a quantitative methodology and a survey method. The research sample consists of employees in private organizations engaged in software engineering. To analyze, SPSS is employed by the author in two stages: first validity-reliability examination, second multiple regression tests. The result demonstrated that quality system has a significant affect on …

Multi-Ancestry Genome-Wide Association Meta-Analysis Of Parkinson’S Disease, Jonggeol Jeffrey Kim, Dan Vitale, Diego Véliz Otani, Michelle Mulan Lian

Faculty Journal Articles

No abstract provided.

Vol.51 N.23 December 28th 2023, Voice Media Ventures

Black Voice News

No abstract provided.

The Crimson (Dec.), Yannick L. Brookes

Office of Student Affairs

Student newsletter - End of Semester Edition

Analisis Faktor-Faktor Yang Memengaruhi Niat Penggunaan Berkelanjutan E-Wallet, Jonathan Ariel, Ira Iriyanti

Jurnal Manajemen dan Usahawan Indonesia

The development of technology led to a series of disruptions that replaced conventional financial systems. The emergence of COVID-19 pandemic accelerated the adoption of digital financial services, one of which is e-wallet. With pandemic over, e-wallet companies must be able to retain their users and made sure they continue to use e-wallet for transaction. Hence, this research aims to understand the factors determining user’s intention to continue using e-wallet as their payment method. This research applies Technology Continuation Theory with the extension of Trust, Habit, Price Benefit, and Operational Constraints. This research gathered data from 251 respondents who lives on …

Outcome Of Endovascular Procedure In Chronic Limb Ischemia Femoropopliteal Lesion: A Literature Review, Alexander J. Utama, Robby E. Thio

The New Ropanasuri Journal of Surgery

Introduction. Angioplasty and stenting are the two main endovascular treatments for femoropopliteal lesions associated with chronic limb ischemia. To summarize the research in this area, this article examines the state of these treatments today, diving into clinical subtleties and new trends. The objectives was to thoroughly analyze the body of research, combining knowledge about the results of endovascular angioplasty and stenting.

Methods: Literature was searched in some databases (Cochrane, PubMed, and EBSCO) from June to July 2021.

Results: Five articles that met the inclusion and exclusion criteria were identified. There were two randomized control trials and three cohort …

Open Sympathectomy Effectiveness On Buerger's Disease’S Pain: An Evidence–Based Case Report, Rangga S. Prawiro, Alexander J. Utama

The New Ropanasuri Journal of Surgery

Introduction. Thromboangiitis obliterans, often referred to as Buerger's disease, is a vascular disease that causes chronic inflammatory conditions, edema, and vascular obstruction due to blood clots. In Cipto Mangunkusumo General Hospital (CMGH), sympathectomy is a rarely done procedure. This evidence–based case report aimed to prove the effectiveness of sympathectomy for Buerger's Disease to reduce pain.

Method. We reported a case of 44–year–old male with progressive pain and a history of darkened fingers of left limbs six months before admission. The patient underwent a lumbar sympathectomy, and there was no recurrence of symptoms after one year of follow–up. A systematic literature …