Digital Commons Network^™

Induction Of Protective Immunity In The Respiratory Tract With Ricin Toxin Immune Complexes, Lindsey Elizabeth Tolman

Legacy Theses & Dissertations (2009 - 2024)

Ricin toxin (RT) is generated in the seeds of Ricinus communis. The highly potent toxin is comprised of two subunits, RTA and RTB. RT enters cells using RTB before RTA separates itself and inactivates the ribosome, inducing cell stress, inflammation, and eventual death. RT is particularly damaging in the respiratory tract, where intoxication induces an inflammatory cytokine storm.Though there are currently no therapeutics for RT intoxication, our group has generated and characterized a wide variety of monoclonal antibodies (mAbs) against RT. Among the top candidates in our collection are the IgGs PB10 and SylH3. Previous studies have demonstrated their exceptional …

Non-Invasive Focused Ultrasound Treatment To Improve Depressive-Like Behavior In A Hemi-Parkinsonian Rat Model, Huda Rehman

ALL - Honors Theses

Parkinson’s disease (PD) is a neurodegenerative disorder in which there is a depletion of dopaminergic neurons in the substantia nigra pars compacta (SNc). Symptoms include those that are motor, such as tremors and rigidity, along with symptoms that are nonmotor, such as depression. Depression in Parkinson’s disease is seen in up to 50% of PD patients, and is often treated with traditional antidepressants, with varying levels of efficacy. In this research project, focused ultrasound was used as a non-pharmacological and non-invasive treatment to improve depressive-like behavior in a hemi-Parkinsonian rat model. To induce a hemi-Parkinsonian phenotype in rats, stereotaxic surgeries …

Three Essays In Health Economics, Tao Jin

Legacy Theses & Dissertations (2009 - 2024)

This dissertation undertakes a comprehensive examination of some market characteristics of the Medicare Part D program and their subsequent effects on the welfare of Medicare beneficiaries. Additionally, it delves into the realm of health behavior, with a specific focus on sleep patterns and their associated outcomes. This dual focus provides a holistic understanding of both the economic and behavioral aspects influencing the health and well-being of individuals.

Camouflaging And Identity Development Among Autistic Female And Gender Diverse Youth: A Qualitative Exploration, Krista Nicole Drapalik

Legacy Theses & Dissertations (2009 - 2024)

Adolescence is a vulnerable developmental period for autistic female and gender diverse youth. Many autistic youths use camouflaging to combat social challenges, perceived differences, and stigmatization. Although adolescence is an integral time for identity development, integration of these topics remains understudied among autistic female and gender diverse youth. The present study seeks to qualitatively explore first-person, youth-perspectives on the topics of camouflaging and identity formation. Ten autistic female and gender diverse youth aged 11 to 16 years (M = 13.1, SD = 1.52) and their caregivers were enrolled in the present study. Youths completed semi-structured interviews and focus group discussions. …

The Association Between Maternal Exposure To Traffic-Related Air Pollution And Neonatal Death, Low Birthweight, And Orofacial Clefts Among Newborns In New York State, Excluding New York City (1999-2019), Douglas Done

Legacy Theses & Dissertations (2009 - 2024)

The following dissertation describes three case-control studies designed to investigate the association between maternal exposure to traffic-related air pollution (TRAP) and the following three outcomes in newborns: 1) neonatal death; 2) low birthweight; and 3) orofacial clefts. Exposure to TRAP will be assessed using distance-weighted traffic density (DWTD), measured in vehicles per day (VPD) that accounts for all roadways within 228.6-meter (750 ft) of the mother’s residence at the time of birth and the intensity of their average annual daily traffic (AADT) based on roadway and traffic data collected by the NYS Department of Transportation (NYS DOT) from 1995 to …

Toward A Process-Based Account Of Mental Health Self-Stigma And Distress: Elucidating The Contribution Of Psychological Inflexibility And Its Six Component Subprocesses, Sara V. White

Legacy Theses & Dissertations (2009 - 2024)

Background: Stigma about mental health and illness remains a pervasive public health concern. Moreover, stigmatizing oneself for experiencing a mental health disorder is associated with further psychological distress. Yet, processes that may account for this relation remain unclear. Thus, the present study aimed to elucidate processes that may account for this relationship, with specific attention to psychological inflexibility as a transdiagnostic mediator between self-stigma and psychological distress. Methods: Undergraduates (N = 486, Mage = 18.68, SDage = 1.31, 66% Female) completed a battery of measures assessing self-stigma, psychological inflexibility, and psychological distress. We tested psychological inflexibility and its six subprocesses …

Adverse Family Experiences And Ethnicity As Risk And Resiliency Factors In The Link Between Psychological Distress And Perception Of Academic Stress In Undergraduate Students, Teresa Mejia

Legacy Theses & Dissertations (2009 - 2024)

Mental health problems have been associated with lower academic performance amongundergraduate students. In addition to individual well-being, environmental and cultural factors may contribute to greater academic stress. Specifically, early adverse family experiences (e.g., abuse, neglect, and family conflict) can have deleterious impacts on an individual’s emotional adjustment and perception of academic stress. However, the influence of ethnicity on the link between early family adversity and later academic stress has been largely understudied. Objective: This study examined whether adverse family experiences and ethnicity moderate the link between psychological distress and academic stress. Methods: Participants (N = 284, 38.4% male, 59.5% female, …

Prescription Opioid Misuse Among High School Students In The United States, By Sex And Race/Ethnicity, In 2019 And 2021, Deepika Reddy Kandhi

Legacy Theses & Dissertations (2009 - 2024)

Background: Drug overdose deaths in the U.S. have been increasing and are primarily related to opioid use. In 2019, an estimated 7.2% of US high school students reported misusing prescription opioids in the past 30 days. Prescription opioid misuse in adolescents may lead to development of a substance use disorder, overdose, or other serious harms. Some researchers have observed sex and race differences in prescription opioid use. This study aimed to identify patterns of prescription opioid misuse among adolescent subgroups categorized by both sex and race/ethnicity, to provide insight into intervention development and targeting.Methods: We analyzed data from the Youth …

El Leñador, December 2023, El Leñador Staff

El Leñador Newspaper

El Leñador is an English and Spanish newspaper produced by Humboldt State University students. Our staff cover and provide news to Latinx and other diverse communities on campus and in Humboldt County. We are committed to providing relevant news and expanding the representations and stories told about people of color and other marginalized groups. Our work helps create more social, political and cultural diversity in local media.

El Leñador es un periodico en español y inglés producido por estudiantes de la Universidad Estatal de Humboldt. Nuestro personal cubre y provee noticias a la comunidad Latinx y otras comunidades diversas en …

Postpartum Visitation Policies, Jenna B. Holderman, Morgan E. Matthews

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Background: Continual support for the birthing person during labor improves delivery outcomes and overall childbirth experiences. How many support people are present and their relation to the birthing person varies based on individual preference, family dynamics, and sociocultural expectations. During the Covid-19 pandemic, many hospitals implemented a one-visitor policy for deliveries. With these new guidelines in place, the length of hospital stays significantly decreased, and there were a variety of opinions towards these restrictions.

Purpose: The purpose of this study was to explore birthing persons’ overall sentiment towards visitors in the immediate postpartum period.

Methods: The current study analyzed …

Moral Distress In Critical Care Nursing: A Literature Review, Anna Tindell

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Moral distress is a pressing concern in the healthcare field with significant implications for all areas of nursing and patient outcomes. However, those within the specialty of critical care nursing experience moral distress more frequently than those in other specialties. It arises from the complex ethical dilemmas nurses in critical intensive care units face as they work in these high-pressure environments. The purpose of this literature review is to discuss moral distress in critical care nursing and how it affects a nurse’s ability to provide quality care. Furthermore, this review will determine factors contributing to moral distress and potential interventions …

Breastfeeding In Public: A Review Of Literature And Service Learning Experience, Taylor Jehlik, Makenzie Carney

The Eleanor Mann School of Nursing Undergraduate Honors Theses

This article explores the perceptions and beliefs of first-time expectant mothers, their family members, and their social network about breastfeeding in public places. We used experience through Tiny Tusks and reviewed literature to get a better understanding of what social factors play a role in mothers' decisions to breastfeed in public.

Mrs. Dalloway As A Window For Understanding Life, Kristen Venegas

English (MA) Theses

Virginia Woolf’s Mrs. Dalloway may be dismissed as fiction, and fiction consequently is dismissed as fantasy. However, the novel enables readers to practice an intellectual exercise of meta-awareness that extends beyond the pages and onto real world phenomena. Under a cognitive neuroscience perspective, Mrs. Dalloway is a literary masterpiece due to its hyper- realistic execution of the intimacies of life. Through the narrative style of free-indirect discourse, Woolf illustrates what occurs in the minds of characters as they develop their own perceptions of reality and identity, exposes the fear and inadequacies of mankind’s distress in times of chaos and disorder …

Factors Influencing The Delivery Of Preconception Care Services Among Nursing And Midwifery Students At Aga Khan University, Kenya, Levy Mukolwe

MSc in Advanced Practice Midwifery

Preconception care (PCC) encompasses a range of biomedical, behavioural, and social interventions to improve pregnancy outcomes. However, the effective implementation of PCC services, particularly in developing countries, faces multifaceted challenges. This cross-sectional quantitative descriptive study was conducted among 104 nursing and midwifery students at Aga Khan University and selected through simple random sampling. Data was collected using semi-structured self-administered questionnaires and analyzed using SPSS version 25.0. 69.9% of the respondents were nurses, while 30.1% were midwives. 28.8% of participants knew the definition of PCC. The importance of various PCC components, such as nutritional deficiency screening, genetic risk assessment, environmental hazard …

Moral Virtues: A Quantitative Study On The Impact Of National Culture On Integrity, Andrew I. Ellestad

Doctor of Business Administration (DBA)

Multinational corporations encounter numerous challenges in making ethical decisions as they navigate diverse factors in every country where they conduct business. Building on the theoretical work of Ellestad and Winton, this study tested a main component of their argument. This quantitative analysis looked at the relationship between the national culture an individual resides in and that individual’s level of integrity. Hofstede’s original four dimensions are used in conjunction with Schlenker’s Integrity Scale to explain and quantify those measures. This study examined 160 working and retired individuals in the United States. The findings demonstrate that national power distance and masculinity are …

Inhibition Of Venom Gland V-Atpase Proton Pumps And Their Role In Snake Venom Acidification And Storage, Samuel Kerwin

Master's Theses

Venomous snakes are capable of storing venom for years while maintaining functionality upon injection, with no known harmful impact to their own physiology; however, the mechanisms behind this are poorly understood. Several major components of venom, most notably SVMPs, are autolytic when active, suggesting the presence of an inhibitory environment during storage to preserve venom functionality. It is hypothesized that the venom gland is continuously acidified by vacuolar rotary proton pump mechanisms (V-ATPases) localized in mitochondria-rich cells found in small concentration within the venom gland secretory epithelium, keeping the venom inert at a pH of 5.4-5.6 during the production/storage period. …

Brain Dance And Brain Power: Impact Of Movement On Problem-Solving Skills For Exceptional Learners, Kristin Crain

Master's Theses

The goal of this research was to answer the question: Q1 In what ways do Brain Dance type movements impact problem-solving skills for exceptional learners? The research was completed within the public education setting with a group of volunteer participants including one cooperating teacher and six student participants identified as exceptional learners. The researcher focused on problem-solving skills including identifying a problem, showing work, implementing a solution, and identifying a solution. Research instruments were created based on these skills including a pretest, posttest, and teacher rubric. Student participants completed the pretest prior to being introduced to movement exercises. The researcher …

Dance And Emotional Intelligence: Mitigating Anxiety In The Modern Teen, Bridget Morris

Master's Theses

The purpose of this thesis study was to find if emotional intelligence could be increased through participation in dance classes, and if that increase of emotional intelligence could mitigate anxiety in teens today. The researcher held four dance classes with a total of five 15–16- year-old volunteer participants, all with dance experience. Two research instruments were used and data were analyzed quantitatively. The research questions explored were: Q1 What immediate effects do participating in a dance class have on emotional intelligence? Q2 Which components of emotional intelligence develop the most from participating in dance? The data demonstrated that participation in …

Exploring Moral Distress And Reflective Debriefing As A Potential Intervention Among Intensive Care Unit Nurses, Tegan Camille Jones

Doctoral Scholarly Projects & Capstones

Moral distress is recognized in the literature as a significant problem for nurses working in the intensive care unit (ICU). Moral distress occurs when one knows the right course of action but is unable to follow it due to team or organizational constraints. Moral distress may lead to physical and psychological symptoms resulting in burnout, job attrition, and a negative impact on patient care. While interventions for reducing moral distress among ICU nurses are limited in the literature, one potentially promising approach is reflective debriefing. This Doctor of Nursing Practice (DNP) scholarly project aimed to explore the intensity, frequency, and …

A Review Of The Current Literature On Adult Aural Rehabilitation Programs, Brooke Danielle Gilstad

Doctoral Scholarly Projects & Capstones

Aural rehabilitation is the practice or set of practices included in an audiologists scope of practice that help individuals with hearing loss mitigate the negative effects it might have on their lives. Negative effects of hearing loss include but are not limited to; socioeconomic hardship, decreased quality of life, higher rates of depression, increased risk of falls, third-party disability, increased risk of cognitive decline, and higher rates of dementia. Despite the multitude of negative effects associated with hearing loss there are still people with hearing loss that site reasons not to receive treatment. For individuals that choose treatment there are …

Designing A Culturally Relevant Lifestyle Modification Guide For Primary Care Providers To Improve Diabetes Management In The Hispanic Population., Jesusita Elvira Tafoya

Doctoral Scholarly Projects & Capstones

Diabetes mellitus type II (DMT2) affects the Hispanic population in the United States at an alarming rate, contributing to elevated morbidity and mortality. This growing ethnic group is also disproportionately at risk for obesity and being at a lower socioeconomic status, both of which contribute to DMT2 severity and prevalence. The provision of culturally competent care in the primary care setting using evidence-based lifestyle modifications has the potential to improve DMT2 outcomes among this socioeconomically disadvantaged population. Thus, the expert opinions of eight primary care providers in the Pueblo, Colorado community were sought where half of the patient population identified …

Leveraging Generative Agents: Autonomous Ai With Simulated Personas For Interactive Simulacra And Collaborative Research, James Hutson, Jay Ratican

Faculty Scholarship

The advent of large language models (LLMs) and AI learning have fundamentally reshaped the research landscape, paving the way for novel problem-solving approaches. This paper introduces a unique framework that leverages the capabilities of autonomous AI agents with simulated personas to drive collaborative research in groundbreaking ways. Inspired by a recent study of autonomous agents mirroring human behavior, this concept encourages the use of a cadre of AI agents, each possessing specialized expertise for collective endeavors. By replicating human diversity in teamwork, this approach targets complex and hitherto unsolvable issues. The key to this strategy is persona and emotional simulation, …

A Framework For Creating Systems Change, William Brown, Wynn Rosser

The Foundation Review

This article draws on a system-change framework developed by the Nicholson Foundation as part of a 20-year initiative to substantively change the state of New Jersey’s health and social welfare systems, and modifies and expands a single case study on system change to align with related ideas and concepts. A results-based accountability approach is integrated into the model to draw attention to the importance of monitoring and evaluation of population-based outcomes.

Drawing on extensive literature from systems change and performance management, the discussion provides insight and perspective on contemporary frameworks in systems change and the role of grantmaking foundations. The …

Leading With Shared Values: Developing A Charter Of Principles For Philanthropic Partnerships, Cheryl A. Maurana, John R. Raymond, Christopher Stawski, Joseph E. Kerschner, James C. Rahn

The Foundation Review

The rise of greater individuality in giving — in diversity of beliefs and donor preferences — has resulted in a need to ensure alignment of values and expectations between those entering into funding relationships, and therefore a need to return to giving that recognizes the importance of conditions and considerations that undergird the partnership between the philanthropic organization and awardee.

The Kern Family Foundation’s nearly $88 million investment in the Medical College of Wisconsin represents one example where creating a charter was pivotal to a partnership’s effectiveness. Their charter describes a commitment to shared values, including character, caring, and practical …

Dna Barcoding Indicates Multiple Invasions Of The Freshwater Snail Melanoides Tuberculata Sensu Lato In Florida, Lori Tolley-Jordan, Michael A. Chadwick, Jimmy K. Triplett

Research, Publications & Creative Work

Melanoides tuberculata sensu lato (Thiaridae) are polymorphic female-clonal snails of Asian and African origins that have invaded freshwaters worldwide, including those in Florida. Although the snails have been documented in Florida for at least 70 years, no studies have investigated whether the observed distribution is due to a single introduction or multiple independent invasions. Here, cytochrome oxidase I was used to measure genetic diversity within and among sites in Florida and compare genetic diversity between Florida and other regions of the world. We also examined the relationship between shell morphology and haplotype diversity to determine if shell morphs can serve …

International Tuberculum Sellae Meningioma Study: Preoperative Grading Scale To Predict Outcomes And Propensity-Matched Outcomes By Endonasal Versus Transcranial Approach, Michael Mcdermott

All Publications

Background and objectives: Tuberculum sellae meningiomas are resected via an expanded endonasal (EEA) or transcranial approach (TCA). Which approach provides superior outcomes is debated. The Magill-McDermott (M-M) grading scale evaluating tumor size, optic canal invasion, and arterial involvement remains to be validated for outcome prediction. The objective of this study was to validate the M-M scale for predicting visual outcome, extent of resection (EOR), and recurrence, and to use propensity matching by M-M scale to determine whether visual outcome, EOR, or recurrence differ between EEA and TCA.

Methods: Forty-site retrospective study of 947 patients undergoing tuberculum sellae meningiomas resection. Standard …

Postoperative Stomach Volvulus And Pancreatitis Following A Sleeve Gastrectomy., Shane B Devine, Sam J King, Bradley J Chatterton, Kurt D Knepley

Internal Medicine Resident Research

The laparoscopic sleeve gastrectomy is the most common bariatric surgery performed to promote weight loss and improve obesity-related comorbidities. As the number of patients undergoing sleeve gastrectomy increases, so does the prevalence of complications. It is crucial to recognize both common and unusual complications of sleeve gastrectomy to properly diagnose and manage them. We present a unique case of gastric outlet obstruction not visualized on initial imaging and acute pancreatitis following a sleeve gastrectomy. We recommend performing an endoscopy and ordering serum lipase levels in a patient with negative CT scans but persistent postoperative nausea, vomiting, and abdominal pain. The …

Orpheus, Winter 2023-24: Caffeinated, University Of Dayton

Orpheus: UD's Literary and Artistic Magazine

No abstract provided.

The Unfulfilled Promise Of Environmental Constitutionalism, Amber Polk

UC Law Journal

The political push for the adoption of state-level “green amendments” in the United States has gained significant traction in just the last couple of years. Green amendments add an environmental right to a state’s constitution. Five such amendments were made in the 1970s in Pennsylvania, Montana, Hawaii, Massachusetts, and Illinois. This Article looks in depth at the case law that has developed the contours of these constitutional environmental rights in the wake of the political revival of environmental constitutionalism in the United States. I distill two lessons from this jurisprudence. First, constitutional environmental rights are interpreted by the courts as …

Proving Actionable Racial Disparity Under The California Racial Justice Act, Colleen V. Chien, W. David Ball, William A. Sundstrom

UC Law Journal

Racial disparity is a fact of the United States criminal justice system, but under the Supreme Court’s holding in McCleskey v. Kemp, racial disparities—even sizable, statistically significant disparities—do not establish an equal protection violation without a showing of “purposeful discrimination.” The California Racial Justice Act (CRJA), enacted in 2020 and further amended in 2022, introduced a first-of-its-kind test for actionable racial disparity even in the absence of a showing of intent, allowing for relief when the “totality of the evidence demonstrates a significant difference” in charging, conviction, or sentencing across racial groups when compared to those who are “similarly situated” …