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A Report On H-2a Workers And The Mattawa Community For The Mayor And Mattawa City Council, Audrey Hudgins

International Studies Faculty Scholarship

No abstract provided.

Novel Urine Cell-Free Dna Methylation Markers For Hepatocellular Carcinoma, Selena Lin, Wei Xia, Amy Kim, Dion Chen, Shelby Schleyer, Lin Choi, Zhili Wang, James Hamilton, Harry Luu, Hie-Won Hann, Ting-Tsung Chang, Chi-Tan Hu, Abashai Woodard, Terence Gade, Ying-Hsiu Su

Division of Gastroenterology and Hepatology Faculty Papers

An optimized hepatocellular carcinoma (HCC)-targeted methylation next generation sequencing assay was developed to discover HCC-associated methylation markers directly from urine for HCC screening. Urine cell-free DNA (ucfDNA) isolated from a discovery cohort of 31 non-HCC and 30 HCC was used for biomarker discovery, identifying 29 genes with differentially methylated regions (DMRs). Methylation-specific qPCR (MSqPCR) assays were developed to verify the selected DMRs corresponding to 8 genes (GRASP, CCND2, HOXA9, BMP4, VIM, EMX1, SFRP1, and ECE). Using archived ucfDNA, methylation of GRASP, HOXA9, BMP4, and ECE1, were found to be significantly different (p < 0.05) between HCC and non-HCC patients. The four markers together with previously reported GSTP1 and RASSF1A markers were assessed as a 6-marker panel in an independent training cohort of 87 non-HCC and 78 HCC using logistic regression modeling. AUROC of 0.908 (95% CI, 0.8656-0.9252) was identified for the 6-marker panel with AFP, which was significantly higher than AFP-alone (AUROC 0.841 (95% CI, 0.778-0.904), p = 0.0026). Applying backward selection method, a 4-marker panel was found to exhibit similar performance to the 6-marker panel with AFP having 80% sensitivity compared to 29.5% by AFP-alone at a specificity of 85%. This study supports the potential use of methylated transrenal ucfDNA for HCC screening.

Comparison Of Methods For Estimating Instantaneous Turn Radius Of Ackermann Steering Vehicles, Kenneth Gennaro Stutts

Doctoral Dissertations and Master's Theses

The instantaneous turn radius of an Ackermann steering vehicle is the distance to a point in space about which the vehicle will travel in an arc during a turn. There are at least six ways to estimate instantaneous turn radius and each method uses different inputs and has distinct advantages and disadvantages. In this thesis, six different methods will be used to estimate the instantaneous turn radius of a vehicle traveling on a closed circuit. This testing will clarify similarities and differences between the methods. This thesis clarifies which method will be the most appropriate for a given set of …

Continuity Of Care In The Post-Partum Period, Ashley Quezada

MSN Capstone Projects

Maternal mortality rates in the United States have been a growing concern over the past decade, with rates continuing to climb as recent studies have been published. The total maternal mortality rate in the United States in 2018 was 17.4 and has increased to 32.9 as of 2021, while other developed countries continue to decline (Hoyert, 2023). The maternal mortality rate is the number of deaths per 100,000 live births. More than 50% of pregnancy-related deaths in the United States occur after delivery, in the post-partum period (Melillo, 2020). The purpose of this report is to not only bring light …

Youth Identity And Postsecondary Decision Making In A Rural State: Evidence Of A College For All Master Narrative, Jayson Seaman, Cindy L. Hartman, Andrew D. Coppens, Erin H. Sharp, Sarah Jusseaume, Molly Donovan

Faculty Publications

This study examined the normative messages that inform youth postsecondary decision making in a predominantly rural state in the northeastern U.S., focusing on the institutionalization and circulation of identity master narratives. Using a multilevel, ecological approach to sampling, the study interviewed 33 key informants in positions of influence in educational, workforce, and quality of life domains. Narrative analysis yielded evidence of a predominant master narrative – College for All – that participants described as a prescriptive expectation that youth and families orient their postsecondary planning toward four-year, residential baccalaureate degree programs. Both general and domain-specific aspects of this master narrative …

Isolation Of The Toxic Principle Of Senecio Latifolius By Means Of The Sensory Receptors Of Sheep, Leendert D. Snyman

Poisonous Plant Research (PPR)

The aversive substance of Senecio latifolius was isolated by means of the sensory receptors of sheep averted to S. latifolius. Chemical fractions refused due to the presence of the aversive substance sensed by the sheep were fractionated until a purified substance had been isolated. Nuclear magnetic resonance (NMR) analysis of the purified substance showed it to be sceleratine nitrogen oxide, the toxic principle of S. latifolius.

The Grizzly, December 7, 2023, Marie Sykes, Erin Corcoran, Georgia Gardner, Hannah Conley, Kate Horan, Sean Mcginley, Amelia Kunko, Dominic Minicozzi

Ursinus College Grizzly Newspaper, 1978 to Present

Spring 2023 Recap • Fall 2023 Recap • Farewell From the News Editor • Farewell From the Web Editor • Students Surprise With Spotify Wrapped Lists • 2023 Crossword • Reflections From Ursinus' December Graduates • Ursinus Athletics Fall 2023 Recap: Men's • Ursinus Athletics Fall 2023 Recap: Women's

Coach-Athlete Conflict And Well-Being Outcomes For Division I Athletes, Alisha M. Hilliard

Dissertations

The purpose of the research was: to qualitatively explore and further understand NCAA Division I (DI) athletes’ experiences with coach conflict and the impact of that conflict on well-being. To serve the purpose of this research, the primary researcher used a purposive sample of DI student-athletes by contacting them directly or sharing the study with faculty, graduate students, and athletic department personnel who work with student-athletes. An interpretive phenomenological approach was utilized while engaging in qualitative inquiry to pursue richer answers to the research question, because these approaches “seek to explore, describe, and analyze the meaning of individual lived experience” …

Lessons Learnt In The First Year Of An Australian Pediatric Cardio Oncology Clinic., Claudia Toro, Ben Felmingham, Mangesh Jhadav, David S. Celermajer, Andre La Gerche, John O'Sullivan, Sanjeev Kumar, Marion K. Mateos, Joy M. Fulbright, Dinisha Govender, Lane Collier, Michael Cheung, David D. Eisenstat, Peter W. Lange, Julian Ayer, David A. Elliott, Rachel Conyers

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Modern oncological therapies together with chemotherapy and radiotherapy have broadened the agents that can cause cardiac sequelae, which can manifest for pediatric oncology patients while on active treatment. Recommendations for high-risk patients who should be monitored in a pediatric cardio-oncology clinic have previously been developed by expert Delphi consensus by our group. In 2022 we opened our first multidisciplinary pediatric cardio-oncology clinic adhering to these recommendations in surveillance and management.

OBJECTIVES: Our pediatric cardio-oncology clinic aimed to: (i) Document cardiovascular toxicities observed within a pediatric cardio-oncology clinic and. (ii) Evaluate the applicability of the Australian and New Zealand Pediatric …

Alt Free Flap Coverage After Carotid Endarterectomy In The Setting Of Severe Radiation Changes, Richard F. Guidry, Hannah E. Doran, Mark W. Stalder

School of Medicine Faculty Publications

Carotid endarterectomy with patch angioplasty is commonly performed for severe atherosclerotic disease to reduce stroke risk. After neck radiation, loss of tissue planes; reactive fibrosis of skin; contraction; and rarely, necrosis of skin may occur, leading to severe wound complications and possible exposure of carotid artery reconstruction. Historically, local myocutaneous flaps have been performed to provide soft tissue coverage; however, these procedures may be associated with increased donor site morbidity and can be affected by radiation changes. This report describes the novel use of a fasciocutaneous free flap for durable vascularized soft tissue, and the associated secondary benefit of improved …

Integrating Stakeholder Feedback Into The Design Of A Peer-Delivered Primary Care Wellness Program: A Rapid Qualitative Study, Emily M. Johnson, Kyle Possemato, Matthew Chinman, Gala True, Jacob Hedges, Brittany N. Hampton, E. Jennifer Edelman, Stephen A. Maisto

School of Medicine Faculty Publications

Background: Individuals seen in Primary Care with behavioral health concerns who decline behavioral health treatment may benefit from the support of peers (consumers in recovery from behavioral health concerns employed to support other consumers). Whole Health STEPS is a new intervention for Veterans in Primary Care with behavioral health concerns which combines essential elements of peers’ role and the Whole Health model using a stepped-care design. We incorporated stakeholder feedback in the Whole Health STEPS design to improve fit with Veterans, peers, and primary care settings. Methods: We conducted semi-structured qualitative interviews with VA staff using questions derived from the …

Ai-Based Digital Image Dietary Assessment Methods Compared To Humans And Ground Truth: A Systematic Review, Eleanor Shonkoff, Kelly Copeland Cara, Xuechen Pei, Mei Chung, Shreyas Kamath, Karen Panetta, Erin Hennessy

Health Sciences Faculty Publications

Objective: Human error estimating food intake is a major source of bias in nutrition research. Artificial intelligence (AI) methods may reduce bias, but the overall accuracy of AI estimates is unknown. This study was a systematic review of peer-reviewed journal articles comparing fully automated AI-based (e.g. deep learning) methods of dietary assessment from digital images to human assessors and ground truth (e.g. doubly labelled water).

Materials and Methods: Literature was searched through May 2023 in four electronic databases plus reference mining. Eligible articles reported AI estimated volume, energy, or nutrients. Independent investigators screened articles and extracted data. Potential sources of …

Evaluating Strategic Leadership Development Programs, Felicia Littlejohn

Instructional Design Capstones Collection

Companies that lack an in-depth understanding of leadership development program evaluation may invest in a program that achieves suboptimal results. However, there is no generally prescribed framework for the evaluation of leadership development programs. Thus, the purpose of this action research paper is to provide the basis for vetting leadership development programs based on their organizational fit and investment value, training methodologies, workplace development approaches, coaching and development support, and targeted business outcomes.

Enhancing Self-Awareness And Interpersonal Communication: A Study Of The Enneagram System And College Students Within Career Development Contexts, Eva Grace Lizarraga

Honors Program Theses and Research Projects

By combining a theoretical framework and existing research to the results of an original study, the Enneagram system and its impact on the self-awareness and self-perceived interpersonal communication among college students is analyzed. Conducted within the context of a Communication Studies Senior Capstone class focused on curriculum for career development, the study examines the Enneagram Assessment experience of 18 students at St. Mary’s University, San Antonio, Texas. The effectiveness of the assigned Enneagram Assessment was evaluated through the students' feedback, specifically in regards to their self-perceptions and understanding of their own communication styles. Results revealed that most students found the …

Abstinence Restores Cardiac Function In Mice With Established Alcohol-Induced Cardiomyopathy, Joshua M. Edavettal, Nicholas R. Harris, Sarah E. Cohen, Janos Paloczi, Bysani Chandrasekar, Jason D. Gardner

School of Graduate Studies Faculty Publications

Alcohol-induced cardiomyopathy (ACM) has a poor prognosis with up to a 50% chance of death within four years of diagnosis. There are limited studies investigating the potential of abstinence for promoting repair after alcohol-induced cardiac damage, particularly in a controlled preclinical study design. Here, we developed an exposure protocol that led to significant decreases in cardiac function in C57BL6/J mice within 30 days; dP/dt max decreased in the mice fed alcohol for 30 days (8054 ± 664.5 mmHg/s compared to control mice: 11,188 ± 724.2 mmHg/s, p < 0.01), and the dP/dt min decreased, as well (−7711 ± 561 mmHg/s compared to control mice: −10,147 ± 448.2 mmHg/s, p < 0.01). Quantitative PCR was used to investigate inflammatory and fibrotic biomarkers, while histology was used to depict overt changes in cardiac fibrosis. We observed a complete recovery of function after abstinence (dP/dt max increased from 8054 ± 664 mmHg/s at 30 days to 11,967 ± 449 mmHg/s after abstinence, p < 0.01); further, both inflammatory and fibrotic biomarkers decreased after abstinence. These results lay the groundwork for future investigation of the molecular mechanisms underlying recovery from alcohol-induced damage in the heart.

Strategies For Improving Small Farm Profitability In Sierra Leone, Christian Joe Sama

Walden Dissertations and Doctoral Studies

No abstract provided.

Ai In Higher Education And Research, Leo Lo, Laura J. Hall

Biomedical Informatics Seminar Series (BioMISS)

Description:

Artificial Intelligence holds great promise for higher education from helping students learn more efficiently to entering the job market better prepared for the future. It’s also transforming the way in which faculty conduct research. This session of the BioMISS seminar series will focus on AI trends and explore application in research.

Learning Objectives

1. Learn about how generative AI is being integrated into higher education, with some specific examples from initiatives at the University of New Mexico (UNM).
2. Gain a greater understanding of generative AI capabilities and limitations.
3. Insight into the importance of critically assessing information produced by AI …

Characterizing Stress Granule Regulation By Pas Kinase, Ataxin-2 And Ptc6 And Investigating The Lifespan Of Covid-19 Virus On Currency, Colleen R. Newey

Theses and Dissertations

The protein Ataxin-2 is a known positive regulator of stress granules in humans, mice and yeast (known as yeast PBP1). Due to the role that stress granules play in diseases including Amyotrophic Lateral Sclerosis (ALS) and cancer, this thesis investigates the role of Ataxin-2 and its protein binding partners in stress granule development and its effects on various metabolic phenotypes of the cell. PAS kinase is a sensory protein kinase, conserved from yeast to man, which regulates respiration and lipid biosynthesis. Our lab discovered that PAS kinase phosphorylates and activates Ataxin-2 in yeast, and that PAS kinase overexpression enhances localization …

Soil Health In American Sports Fields, Miria C. Barnes

Theses and Dissertations

Healthy soils are essential for sustaining the world's ecosystems and maintaining human lifestyles. The adoption of biological, chemical, and physical analyses to assess soil health is a relatively new concept with a paucity of scientific work assessing how these metrics are affected by field management in urban systems Soil samples (n = 110) were collected from a diverse range of sports fields and, for comparative purposes, golf courses, farm fields, non-sport urban, undisturbed forest, and non-vegetated sandy soils. The samples were then analyzed using biological, chemical, and physical metrics to determine if there were significant differences between sport/golf venues and …

Twitch Chat Advertising: How Live Chat Valence Affects Consumer Advertising Perceptions, Austin W. Camper

Theses and Dissertations

The streaming platform Twitch.tv, is a popular video streaming website where users can watch, communicate, and chat with streamers and other viewers live. Twitch and other live streaming websites typically offer viewers a chat window where the viewer can chat (in real-time) with the streamer and other viewers who are currently watching the stream. Research in live streaming platforms like Twitch and the effects of their various features are novel. The purpose of this study is to analyze how the sentiment of a live chat (positive or negative) and the stated or not stated disclosure of an advertisement posted in …

Mitochondrial Dna Variants At Low-Level Heteroplasmy And Decreased Copy Numbers In Chronic Kidney Disease (Ckd) Tissues With Kidney Cancer, Yuki Kanazashi, Kazuhiro Maejima, Todd A Johnson, Shota Sasagawa, Ryosuke Jikuya, Hisashi Hasumi, Naomichi Matsumoto, Shigekatsu Maekawa, Wataru Obara, Hidewaki Nakagawa

Faculty, Staff and Student Publications

The human mitochondrial genome (mtDNA) is a circular DNA molecule with a length of 16.6 kb, which contains a total of 37 genes. Somatic mtDNA mutations accumulate with age and environmental exposure, and some types of mtDNA variants may play a role in carcinogenesis. Recent studies observed mtDNA variants not only in kidney tumors but also in adjacent kidney tissues, and mtDNA dysfunction results in kidney injury, including chronic kidney disease (CKD). To investigate whether a relationship exists between heteroplasmic mtDNA variants and kidney function, we performed ultra-deep sequencing (30,000×) based on long-range PCR of DNA from 77 non-tumor kidney …

The Montclarion, December 7, 2023, The Montclarion

The Montclarion

Student Newspaper of Montclair State University

Executive Functioning And Self-Regulation Learning In The Early Childhood Years, A Calming Safe Space To Support The Emotional Development Of Young Children., Amy Strunc

Dissertations, Theses, and Projects

Early childhood special education (ECSE) teachers often serve as a resource for classroom teachers, assistants, parents, paraprofessionals, and administration seeking behavioral guidance. Children need to be equipped with strategies to regulate their emotions before they reach the point of outbursts, elopement, shutdowns, or aggressive behavior. Classroom calm-down spaces are essential for all children to take a break and practice self-regulation, initially learning through co-regulation with teachers. This project aims to provide a framework for providing explicit instruction to children to manage their emotions at the earliest signs of dysregulation, enabling them to remain in the learning zone. The project also …

Carbapenem Resistant Enterobacterales In The United Arab Emirates: A Retrospective Analysis From 2010 To 2021, Jens Thomsen, Najiba M. Abdulrazzaq, The Uae Amr Surveillance Consortium, Dean B. Everett, Godfred Antony Menezes, Abiola Senok, Carole Ayoub Moubareck

All Works

Carbapenem-resistant Enterobacterales (CRE) are spreading in the United Arab Emirates (UAE) where their dissemination is facilitated by international travel, trade, and tourism. The objective of this study is to describe the longitudinal changes of CRE as reported by the national AMR surveillance system of the UAE. In this study, we retrospectively describe CRE isolated from 317 surveillance sites, including 87 hospitals and 230 centers/clinics from 2010 to 2021. The associated clinical, demographic, and microbiological characteristics are presented by relying on the UAE national AMR surveillance program. Data was analyzed using WHONET microbiology laboratory database software (http://www.whonet.org). A total of 14,593 …

Methicillin Resistant Staphylococcus Aureus In The United Arab Emirates: A 12-Year Retrospective Analysis Of Evolving Trends, Jens Thomsen, Najiba M. Abdulrazzaq, The Uae Amr Surveillance Consortium, Godfred Antony Menezes, Carole Ayoub Moubareck, Dean B. Everett, Abiola Senok

All Works

IntroductionMethicillin resistant Staphylococcus aureus (MRSA) is a major contributor to the global burden of antimicrobial resistance (AMR). As MRSA continues to evolve, the need for continued surveillance to evaluate trends remains crucial. This study was carried out to assess MRSA trends in the United Arab Emirates (UAE) based on analysis of data from the national AMR surveillance program.MethodsWe carried out a 12-year (2010–2021) retrospective analysis of MRSA demographic and microbiological data collected as part of the UAE national AMR surveillance program. Participating centers from across the country routinely submit AMR surveillance data collected by trained personnel to the National AMR …

Expressions Of Femininity In Fantasy Settings, Samantha Schultz

Honors Theses

Expressions of Femininity in Fantasy Settings is a Creative Writing Thesis focused on examining different ways femininity is expressed in fantastical settings. These fantastical settings include societies that are both different and similar to our own, with fantasy elements present. The stories include a matriarchal, dragon riding society that thrives off the pressure faced by both sides to keep the present system intact. A purportedly gender-neutral society that allows young people to choose their gender presentation when they come of age, as well as the consequences and benefits that come along with it. And a patriarchal society, zoomed in to …

Violence Against Healthcare Workers, Nichole Osgood

Honors Theses

Workplace violence is any act or threat of physical violence, harassment, intimidation, or other threatening disruptive behavior that occurs at work (US Department of Labor, 2023). There are a handful of different types of workplace violence that include but are not limited to physical violence, verbal abuse and threats, sexual harassment, and psychological trauma (US Department of Labor, 2023). Workplace violence, a multifaceted phenomenon, is not a new concern, but its pervasiveness and intensity in healthcare settings have reached alarming proportions in recent years. In a meta-analysis, it was noted that workplace violence against healthcare workers of any kind was …

Safe Patient Care Act Advocation, Julia Rhodes

Honors Theses

This paper discusses advocating for the Safe Patient Care Act and how it affects people in society. This topic is very relevant because it affects a vast majority of people including nurses, patients, and the healthcare systems as a whole. Methods used to advocate for this bill include grass roots activism, composing and presenting speeches, scheduling and attending meetings, presenting to different nursing school cohorts, collaborating with the Michigan Nurses Association, and participating in hearings held by the Michigan House of Representatives. Results consisted of positive feedback from representatives and their word to vote for the Safe Patient Care Act. …

The Cowl - V. 88 N. 25 - December 7, 2023

The Cowl

The Cowl - student newspaper of Providence College. Vol. 88 No. 25 - December 7, 2023. 24 pages.

The Colby Echo (2023-12-07), Colby Coll

The Colby Echo

Published by the students of Colby College since 1877, The Colby Echo is the weekly, editorially independent student-run newspaper of Colby College in Waterville, Maine. Published monthly, 1877-1886; semi-monthly, 1886-1897; and weekly during the academic year, 1898-present.