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Articles 2221 - 2250 of 77327
Full-Text Articles in Entire DC Network
A Multilevel Mhealth Intervention Boosts Adherence To Hydroxyurea In Individuals With Sickle Cell Disease, Jane S Hankins, Allison A King, Ana A Baumann, Lisa M Klesges, Et Al.
A Multilevel Mhealth Intervention Boosts Adherence To Hydroxyurea In Individuals With Sickle Cell Disease, Jane S Hankins, Allison A King, Ana A Baumann, Lisa M Klesges, Et Al.
2020-Current year OA Pubs
Hydroxyurea reduces sickle cell disease (SCD) complications, but medication adherence is low. We tested 2 mobile health (mHealth) interventions targeting determinants of low adherence among patients (InCharge Health) and low prescribing among providers (HU Toolbox) in a multi-center, non-randomized trial of individuals with SCD ages 15-45. We compared the percentage of days covered (PDC), labs, healthcare utilization, and self-reported pain over 24 weeks of intervention and 12 weeks post-study with a 24-week preintervention interval. We enrolled 293 patients (51% male; median age 27.5 years, 86.8% HbSS/HbSβ0-thalassemia). The mean change in PDC among 235 evaluable subjects increased (39.7% to 56.0%; P < 0.001) and sustained (39.7% to 51.4%, P < 0.001). Mean HbF increased (10.95% to 12.78%; P = 0.03). Self-reported pain frequency reduced (3.54 to 3.35 events/year; P = 0.041). InCharge Health was used ≥1 day by 199 of 235 participants (84.7% implementation; median usage: 17% study days; IQR: 4.8-45.8%). For individuals with ≥1 baseline admission for pain, admissions per 24 weeks declined from baseline through 24 weeks (1.97 to 1.48 events/patient, P = 0.0045) and weeks 25-36 (1.25 events/patient, P = 0.0015). PDC increased with app use (P < 0.001), with the greatest effect in those with private insurance (P = 0.0078), older subjects (P = 0.033), and those with lower pain interference (P = 0.0012). Of the 89 providers (49 hematologists, 36 advanced care providers, 4 unreported), only 11.2% used HU Toolbox ≥1/month on average. This use did not affect change in PDC. Tailoring mHealth solutions to address barriers to hydroxyurea adherence can potentially improve adherence and provide clinical benefits. A definitive randomized study is warranted. This trial was registered at www.clinicaltrials.gov as #NCT04080167.
Single-Cell Atlas Of Healthy Human Blood Unveils Age-Related Loss Of Nkg2c+Gzmb−Cd8+ Memory T Cells And Accumulation Of Type 2 Memory T Cells, Marina Terekhova, Amanda Swain, Pavla Bohacova, Ekaterina Aladyeva, Laura Arthur, Anwesha Laha, Denis A Mogilenko, Samantha Burdess, Vladimir Sukhov, Denis Kleverov, Barbora Echalar, Petr Tsurinov, Roman Chernyatchik, Kamila Husarcikova, Maxim N Artyomov
Single-Cell Atlas Of Healthy Human Blood Unveils Age-Related Loss Of Nkg2c+Gzmb−Cd8+ Memory T Cells And Accumulation Of Type 2 Memory T Cells, Marina Terekhova, Amanda Swain, Pavla Bohacova, Ekaterina Aladyeva, Laura Arthur, Anwesha Laha, Denis A Mogilenko, Samantha Burdess, Vladimir Sukhov, Denis Kleverov, Barbora Echalar, Petr Tsurinov, Roman Chernyatchik, Kamila Husarcikova, Maxim N Artyomov
2020-Current year OA Pubs
Extensive, large-scale single-cell profiling of healthy human blood at different ages is one of the critical pending tasks required to establish a framework for the systematic understanding of human aging. Here, using single-cell RNA/T cell receptor (TCR)/BCR-seq with protein feature barcoding, we profiled 317 samples from 166 healthy individuals aged 25-85 years old. From this, we generated a dataset from ∼2 million cells that described 55 subpopulations of blood immune cells. Twelve subpopulations changed with age, including the accumulation of GZMK
Index To Volumes 31 And 32, 2003-2004, Bird Observer
Index To Volumes 31 And 32, 2003-2004, Bird Observer
Bird Observer
No abstract provided.
Peregrine Falcons In Massachusetts In 2004, Thomas W. French
Peregrine Falcons In Massachusetts In 2004, Thomas W. French
Bird Observer
No abstract provided.
Watching Nighthawks In The Blackstone National Corridor, Mark Lynch
Watching Nighthawks In The Blackstone National Corridor, Mark Lynch
Bird Observer
No abstract provided.
Field Notes, Dan Furbish, Carolyn B. Marsh
Health Tips For Birders, Petti Staub
The Phalarope Conspiracy, Kathleen S. Anderson
About Books: Four Anomalous Volumes: Pampered Birds, Missing Birds, Dead Birds, And Bird Leftovers, Mark Lynch
About Books: Four Anomalous Volumes: Pampered Birds, Missing Birds, Dead Birds, And Bird Leftovers, Mark Lynch
Bird Observer
No abstract provided.
The Snowy Owl Satellite Telemetry Project, Norman Smith
The Snowy Owl Satellite Telemetry Project, Norman Smith
Bird Observer
No abstract provided.
The Saw-Whet Owl Banding Project, Danielle Smith
Young Birders: A Winter Outing, David Allen
About Books: Opposite Sides Of The Same Coin, Mark Lynch
About Books: Opposite Sides Of The Same Coin, Mark Lynch
Bird Observer
No abstract provided.
Young Birders: The Benefits Of Bird Banding, Yelena Samsonenko
Young Birders: The Benefits Of Bird Banding, Yelena Samsonenko
Bird Observer
No abstract provided.
Young Birders: Close Encounters Of The Avian Kind, Andrew P. Brissette
Young Birders: Close Encounters Of The Avian Kind, Andrew P. Brissette
Bird Observer
No abstract provided.
Field Notes, Peter Trull, Aaron Roth, Maura J. Amrich
Field Notes, Peter Trull, Aaron Roth, Maura J. Amrich
Bird Observer
No abstract provided.
Modeling The Potential Impacts Of Climate Change On The Summer Distributions Of Massachusetts Passerines, Jeff Price
Modeling The Potential Impacts Of Climate Change On The Summer Distributions Of Massachusetts Passerines, Jeff Price
Bird Observer
No abstract provided.
Birding The Lower Emerald Necklace: Jamaica Pond To The Back Bay, Robert G. Mayer
Birding The Lower Emerald Necklace: Jamaica Pond To The Back Bay, Robert G. Mayer
Bird Observer
No abstract provided.
Silvicultural Options For Managing Birds In Northern Hardwoods Forests In Extensively Forested Landscapes, David I. King, Richard M. Degraaf
Silvicultural Options For Managing Birds In Northern Hardwoods Forests In Extensively Forested Landscapes, David I. King, Richard M. Degraaf
Bird Observer
No abstract provided.
Birding The Blackstone Valley: Uxbridge-Northbridge, Massachusetts, Richard W. Hildreth, Strickland Wheelock
Birding The Blackstone Valley: Uxbridge-Northbridge, Massachusetts, Richard W. Hildreth, Strickland Wheelock
Bird Observer
No abstract provided.
He Spanned Two Eras: Charles Foster Batchelder, Last Of The "Shotgun" Ornithologists, William E. Davis Jr.
He Spanned Two Eras: Charles Foster Batchelder, Last Of The "Shotgun" Ornithologists, William E. Davis Jr.
Bird Observer
No abstract provided.
Birding The Delaney Wildlife Management Area, Simon Hennin, Lisa Hennin
Birding The Delaney Wildlife Management Area, Simon Hennin, Lisa Hennin
Bird Observer
No abstract provided.
The Purple Martin In Massachusetts, David E. Clapp
The Purple Martin In Massachusetts, David E. Clapp
Bird Observer
No abstract provided.
The Mating Game, Marta Hersek
Birding The Great Woods Of Lynn, John Quigley, Joanne Benard
Birding The Great Woods Of Lynn, John Quigley, Joanne Benard
Bird Observer
No abstract provided.
Book Clubs In Massachusetts, Martha Steele
Bird Sightings: November-December 1994 Summary, Richard A. Forster, Marjorie W. Rines, Robert H. Stymeist
Bird Sightings: November-December 1994 Summary, Richard A. Forster, Marjorie W. Rines, Robert H. Stymeist
Bird Observer
No abstract provided.
A Decade Of Snowy Owls At Logan Airport, Norman Smith
A Decade Of Snowy Owls At Logan Airport, Norman Smith
Bird Observer
No abstract provided.
Blue State Exodus?, Jon D. Michaels, David L. Noll
Blue State Exodus?, Jon D. Michaels, David L. Noll
Pepperdine Law Review
American businesses and families are leaving Blue states in record numbers for destinations like Texas, Florida, and Georgia. This migration of people, businesses, and tax dollars has prompted claims of a “Blue state exodus” prompted by “leftist politicians imposing leftist ideology.” As expressed by Utah’s Senator Mike Lee, the “exodus” proves that “the Left’s policies don’t work.” But does the movement of taxpayers from Blue to Red states really signal a rejection of progressive policies? This Essay argues that, before accepting that interpretation, we should consider another possibility. Perhaps Blue states aren’t overly progressive, but insufficiently so. Paralyzed by political …