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Sphingolipids In Neurodegenerative Diseases, Xueyang Pan, Debdeep Dutta, Shenzhao Lu, Hugo J Bellen

Faculty, Staff and Students Publications

Neurodegenerative Diseases (NDDs) are a group of disorders that cause progressive deficits of neuronal function. Recent evidence argues that sphingolipid metabolism is affected in a surprisingly broad set of NDDs. These include some lysosomal storage diseases (LSDs), hereditary sensory and autonomous neuropathy (HSAN), hereditary spastic paraplegia (HSP), infantile neuroaxonal dystrophy (INAD), Friedreich’s ataxia (FRDA), as well as some forms of amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD). Many of these diseases have been modeled in Drosophila melanogaster and are associated with elevated levels of ceramides. Similar changes have also been reported in vertebrate cells and mouse models. Here, we …

Chromosomal Microarray Analysis Supplements Exome Sequencing To Diagnose Children With Suspected Inborn Errors Of Immunity, Breanna J Beers, Morgan N Similuk, Rajarshi Ghosh, Bryce A Seifert, Leila Jamal, Michael Kamen, Michael R Setzer, Colleen Jodarski, Rylee Duncan, Devin Hunt, Madison Mixer, Wenjia Cao, Weimin Bi, Daniel Veltri, Eric Karlins, Lingwen Zhang, Zhiwen Li, Andrew J Oler, Kathleen Jevtich, Yunting Yu, Haley Hullfish, Bibiana Bielekova, Pamela Frischmeyer-Guerrerio, An Dang Do, Laryssa A Huryn, Kenneth N Olivier, Helen C Su, Jonathan J Lyons, Christa S Zerbe, V Koneti Rao, Michael D Keller, Alexandra F Freeman, Steven M Holland, Luis M Franco, Magdalena A Walkiewicz, Jia Yan

Faculty, Staff and Students Publications

PURPOSE: Though copy number variants (CNVs) have been suggested to play a significant role in inborn errors of immunity (IEI), the precise nature of this role remains largely unexplored. We sought to determine the diagnostic contribution of CNVs using genome-wide chromosomal microarray analysis (CMA) in children with IEI.

METHODS: We performed exome sequencing (ES) and CMA for 332 unrelated pediatric probands referred for evaluation of IEI. The analysis included primary, secondary, and incidental findings.

RESULTS: Of the 332 probands, 134 (40.4%) received molecular diagnoses. Of these, 116/134 (86.6%) were diagnosed by ES alone. An additional 15/134 (11.2%) were diagnosed by …

Olli At Unh Spring 2023 Catalog, Dave Kellam

UNH Cooperative Extension

No abstract provided.

Grafton County Highlights 2022, Amy Loader

UNH Cooperative Extension

No abstract provided.

Intra-Marrow Penetrations And Root Coverage Outcomes: A Systematic Review, Vrisiis Kofina, Ving Wang, Alissa V. Fial, Dimitris N. Tatakis

School of Dentistry Faculty Research and Publications

Background

Intra-marrow penetrations (IMPs) have been performed during guided tissue regeneration (GTR) procedures with reported clinical benefits. The aim of this systematic review was to investigate the use and effect of IMPs during root coverage procedures.

Method

A broad search for human and animal studies was performed on PubMed, Cochrane Database of Systematic Reviews and Cochrane Central Registry of Controlled Trials and Web of Science, following a registered review protocol (PROSPERO). All prospective study designs, case series and case reports on gingival recession treatment (follow-up ≥ 6 months) that employed IMPs were included. Root coverage, complete root coverage prevalence, and …

Immunohistochemical Markers Of Temporomandibular Disorders: A Review Of The Literature, Luis Eduardo Almeida, Andrea Doetzer, Matthew L. Beck

School of Dentistry Faculty Research and Publications

Temporomandibular disorders (TMD) are a group of internal derangements encompassing dysfunction, displacement, degeneration of the temporomandibular joints and surroundings muscles of mastication, often accompanied by pain. Relationships between TMD and various chemical biomarkers have been examined throughout the years. This paper aims to gather evidence from the literature regarding other biomarkers and presenting them as one systematic review to investigate the potential links between TMD and different biochemical activity. To identify relevant papers, a comprehensive literature search was carried out in MEDLINE/PubMED, EMBASE, Web of Science and a manual search was performed in the International Journal of Oral and Maxillofacial …

2023 Nh State 4-H Horse Show Ad & Supporter Packet, Mary Davis

UNH Cooperative Extension

No abstract provided.

Original Public Meaning, Lawrence B. Solum

Faculty Scholarship

“Original public meaning” has become increasingly important in constitutional discourse. This Article investigates the nature of original public meaning in three steps. First, each word in the phrase “original public meaning” is explicated and clarified. The word “original” represents the idea that the meaning of the constitutional text is fixed at the time each provision is framed and ratified. The word “public” signifies that the relevant meaning is ordinary meaning, the understanding of the text conveyed to the public at the time each provision was framed and ratified. The word “meaning” refers to the set of ideas (concepts and propositions) …

Lloyd And The Legislative Void: Representative Actions In Transatlantic Context, Suzanne E. Chiodo

All Papers

The Canadian class action regimes have had a strong influence on the development of collective redress procedures in England. Canadian class proceedings legislation provided a model for the competition law class action regime in the UK, and before then, it featured prominently in the Civil Justice Council’s report that recommended the enactment of generic class actions legislation in England. It is fitting, then, that the UK Supreme Court’s recent decision in Lloyd v Google referred to the Canadian jurisprudence on the representative rule, which allows one or more claimants to represent a group with the ‘same interest’. While Lloyd did …

Canadian “Dreamers”: Access To Postsecondary Education, Elise Mercier, Sean Rehaag, Francisco Rico-Martinez

All Papers

Youth with precarious legal status (PLS) in Canada are entitled to access primary and secondary education regardless of their immigration status. However, once they graduate from high school their opportunities for postsecondary education are highly constrained. This article sets out an argument for expanding postsecondary educational opportunities for PLS students, drawing on the example of the only existing program in Canada targeting such students: York University’s “Access for Students with Precarious Immigration Status Program”. The article considers possible legal impediments to the establishment of such programs, including offenses under Canadian immigration legislation, and argues that charges against postsecondary institutions or …

Regulating Health And Safety In Capitalist Workplaces: History, Practices And Prospects, Eric Tucker

All Papers

The chapter provides a broad overview of occupational health and safety (OHS) regulation in advanced capitalist countries with a focus on the English-speaking world. It views OHS regulation through a political economy lens in which protective legislation is enacted and implemented against the imperative of a profit-driven system of production. The chapter provide examines the historical development of OHS regulation beginning with the rise of industrial capitalism leading up to modern OHS regimes that increasing embrace mandated partial self regulation. It then considers contemporary debates over the efficacy of these regimes, focusing on the scope of self regulation, the practice …

Islamic Law And Colonialism, Rabiat Akande, Halimat Adeniran

All Papers

No abstract provided.

Impossibility And Frustration, Jennifer Nadler

All Papers

No abstract provided.

Donepezil Alone And Combined With Intensive Language-Action Therapy On Depression And Apathy In Chronic Post-Stroke Aphasia: A Feasibility Study, Marcelo L Berthier, Lisa Edelkraut, Francisco J López-González, Diana López-Barroso, Bettina Mohr, Friedemann Pulvermüller, Sergio E Starkstein, Ricardo E Jorge, María José Torres-Prioris, Guadalupe Dávila

Faculty, Staff and Students Publications

This study explored the feasibility and effectiveness of a short-term (10-week) intervention trial using Donepezil administered alone and combined with intensive language action therapy (ILAT) for the treatment of apathy and depression in ten people with chronic post-stroke aphasia. Outcome measures were the Western Aphasia Battery and the Stroke Aphasia Depression Questionnaire-21. Structural magnetic resonance imaging and 18fluorodeoxyglucose positron emission tomography were acquired at baseline and after two endpoints (Donepezil alone and Donepezil-ILAT). The intervention was found to be feasible to implement. Large treatment effects were found. Donepezil alone and combined with ILAT reduced aphasia severity, while apathy and depression …

Weplay Denver: The Why And How: Background And Implementation Manual, Lauren Gross

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

WePlay Denver (WePlay and Nosotros Jugamos; see glossary) is a program providing caregiver-infant playgroups designed to teach families with young children the value of play as well as provide information and resources on topics related to child development, family wellbeing, and mental health. WePlay and Nosotros Jugamos are a collaboration between the University of Denver’s Graduate School of Professional Psychology (GSPP) and the Children’s Museum of Denver, Marsico Campus, and are based on a similar program from the Chicago Children’s Museum. WePlay offered its first playgroup in 2019, while Nosotros Jugamos began in 2020.

On The Phenomenon Of Populism And Extremism In The Balkans, Mustafa Cerić

Occasional Papers on Religion in Eastern Europe

This paper is based on my personal experience of war and peace in Bosnia. The basic notion is that it is easier to start a war than to stop it. Thus, postwar recovery or peacebuilding is not easy. But thanks to open-minded people who have been all along against a mythical populism that caused the bloody war against Bosnia and its autochthon people, the peace, although unjust, was reached after all. The focus here is on the idea of pluralism in Bosnia as an opposite to "populism" and "extremism." For a positive narrative like pluralism is a good way to …

The Czech Republic: From The Center Of Christendom To The Most Atheist Nation Of The 21st Century. Part 1. The Persecuted Church: The Clandestine Catholic Church (Ecclesia Silentii) In Czechoslovakia During Communism 1948-1991, Scott Vitkovic

Occasional Papers on Religion in Eastern Europe

This research examines the most important historical, political, economic, social, cultural, and religious factors before, during, and after the reign of Communism in Czechoslovakia from 1918 to 2021 and their effect on the extreme increase in atheism and decrease in Christianity, particularly Roman Catholicism, in the present-day Czech Republic. It devotes special attention to the role of the Clandestine Catholic Church (Ecclesia Silentii) and the changing policies of the Holy See vis-à-vis this Church, examining these policies' impact on the continuing decline of Roman Catholicism in the Czech Republic after the collapse of Communism. The article also deals with Pope …

The War In Ukraine And Political Theology In Poland, Christopher Garbowski

Occasional Papers on Religion in Eastern Europe

In the broadest of terms, political theology can be defined as “the analysis of political arrangements (including cultural-psychological, social, and economic aspects) from the perspective of God’s ways with the world.”¹ Since the world changes, as do the politics accompanying them, political theology is of necessity a dynamic branch of the theological enterprise. The editors to the second edition of The Wiley Blackwell Companion to Political Theology note a number of such changes that justify the expanded second edition of their handbook, including—what is most pertinent for understanding political theology at present in Poland—“the discourse on religion and violence, …

Assistance Given To The Ukrainian Refugees By The Polish People After Russian Invasion Of Ukraine On February 24, 2022, Elžbieta Pakszys

Occasional Papers on Religion in Eastern Europe

My task here is to relate the ways in which the Polish population helps Ukrainian refugees since the beginning of the Russian aggression. Who are these refugees? How do they obtain help? I also want to think about the motivations for such spontaneous willingness to help. What are the presumed reasons for it, and what are the true ones? What is the impact of events from the past on the present situation? Also – whom and why are Poles helping less willingly, namely the so-called ‘problem of refugees’ from behind the Byelorussian boarder.

The Recognition Of The Authocephaly Of The Macedonian Orthodox Church–Archdiocese Of Ohrid And Reflections By The Public: A Twitter Analysis, Ivan Blazevski Phd, Gjoko Gjorgjevski, Ruzhica Cacanoska, Vesna Zabijakin Chatleska, Phd

Occasional Papers on Religion in Eastern Europe

The long-awaited recognition of the Macedonian Orthodox Church – Archdiocese of Ohrid (MOC-OA), initially by the Ecumenical Patriarchate (EP), and later by the Serbian Orthodox Church (SOC), caused numerous reactions in the public. At the same time, the process itself, from the very beginning, was accompanied by ambiguities that resulted from the insufficiently clarified decision of the Ecumenical Patriarchate regarding the Church canons, as well as the confusion regarding the final name under which the Macedonian Orthodox Church will be recognized. All this was accompanied by the frequent use of terms such as Tomos, autocephaly, and the like, the meaning …

The Final Dilemma: Cremation As A Form Of Jewish Burial In Slovakia, Peter Salner

Occasional Papers on Religion in Eastern Europe

This paper seeks to answer the question of why, in the 21st century, Jews from the largest Jewish community in Slovakia have increasingly begun to prefer cremation over traditional Jewish burial. Importantly, Judaism views the act of cremation as a repudiation of faith in the afterlife, which incurs punishment in the form of exclusion from the resurrection after the prophesied coming of the Messiah. There is also a historical case against cremation, based on the Nazis’ burning of the bodies of murdered concentration camp inmates. Ethnological research shows that the main reason for this preferential shift is the Holocaust, one …

Still Sticking To The Big Brother: History, German Protestantism, And The Ukrainian War, Katharina Kunter

Occasional Papers on Religion in Eastern Europe

It has often been revealed, in the great historical upheavals of contemporary history, that a quick, situational ad-hoc assessment and reaction is not the strength of German Protestantism. This was the case after the collapse of Imperial Germany (Kaiserreich) and the sovereign church regiment (Landesherrliches Kirchenregiment; summus episcopus) in 1918, as well as after the end of the Second World War, when German Protestantism was long at odds with democracy and Adenauer's ties to the West.4 The Peaceful Revolution in the GDR in 1989 (during the civic uprisings of 1989/90 in the other Central European countries) also surprised the leaders …

Confession As A Multifunctional Holy Sacrament Of The Ukrainian Orthodox Population Of The 17th-19th Centuries, Olena Borodenko, Vasyl Fazan

Occasional Papers on Religion in Eastern Europe

Цель. Статья посвящена проблеме многофункционального исследования конфессиональной обрядности мировоззрения и религиозной принадлежности украинского православного населения XVII-XIX вв.

Методы исследования . Междисциплинарный интеллект строится с преимуществом формально-логического метода познания в истории религии, социально-религиозной истории и интегрируется с избранными направлениями психологии и философии.

Основные результаты.Святое Таинство Исповеди представлено как проявление искреннего покаяния верующего в своих грехах, с верой в Бога-Творца, в Его милость, с надеждой на исправление жизненных проступков через отпущение грехов священником. По признанию, одним из побудительных факторов можно считать страх и набожность человека. Главной целью религиозного обряда было укрепление соблюдения в обществе христианских нравственных норм нравственности и гражданского права. …

Evolution Of A Protestant Theology Institution In Croatia: From Private Church College To University Center, Lidija Matošević, Marina Schumann, Enoh Šeba

Occasional Papers on Religion in Eastern Europe

The focus of this case study is the Faculty of Theology “Matthias Flacius Illyricus” (Teološki fakultet “Matija Vlačić Ilirik” – TFMVI) in Zagreb, founded by two minority religious communities: the Lutheran Church and the Baptist Union. The authors’ premise is that by examining over forty years of the institution’s existence, prominent trends and attitudes can be identified that continue to shape the interaction between churches and the state within Croatian society, where the Roman Catholic Church represents the overwhelming majority. The authors begin with a historical overview of the position of churches under the Communist regime in Yugoslavia, with particular …

Analysis Of Letters From Representatives Of Religious Bible Student Groups (Badaczy Pisma Świętego) In Poland During The Nazi Occupation, Roman Orlovskii, Denys Shpak

Occasional Papers on Religion in Eastern Europe

The founder and leader of the International Bible Students movement was Charles Taze Russell (1852–1916), an eminent religious figure, the first president of the Watch Tower Society. After his death, the denomination he created split into a number of communities: Jehovah's Witnesses, as well as various groups of Bible Students who refused to recognize the authority of the Watch Tower Society under the rule of subsequent presidents. The followers of these groups, who recognized only the works of Charles Taze Russell, lived in different countries of the world, including in Poland. There are practically no scientific works devoted to the …

Hope Channel Ukraine As "The Spiritual Front": Mediatization Of Religion In The War Against Ukraine, Maksym Balaklytskyi

Occasional Papers on Religion in Eastern Europe

Hope Channel Ukraine (Nadiia TV in Ukrainian) claims to be “the first Christian TV channel in Ukraine.” During the Russian invasion of 2022, its main innovation was the “All-Ukrainian HOPE Marathon” program. It is a live program that is being aired from February 28 to June 22 in morning and evening blocks of one and a half hours. For the first months, the Marathon was broadcast daily without a day off. Since September, it has been aired twice a week under the title “Spiritual Front.” “All-Ukrainian HOPE Marathon ”became the largest live project of Hope Channel Ukraine during its conventional …

The Position Of Ukrainian Protestants Regarding The War In Ukraine: Rebuttal Of False Accusations Of Eurasianism, Valentyna Kuryliak

Occasional Papers on Religion in Eastern Europe

This article analyzes the position of Ukrainian Protestants in relation to the issue of the war between Russia and Ukraine. The position of Professor Pavlo Pavlenko was taken as a basis, who, in most of his publications, claims that the Protestants of Ukraine are pro-Russian, pro-Eurasian, and take a position that is contrary to the national interests of Ukraine. It is proven by the example of the analysis of publications and statements of Ukrainian Protestants that the protection of the national interests of Ukraine after 2014 has become part of their religious culture. The article shows on the example of …

Hagia Sophia, Religious Freedom, And The Destruction Of The Christian Cultural Heritage In Turkey, Ina Merdjanova

Occasional Papers on Religion in Eastern Europe

A lot has happened in the last 10 years in Turkey. The Gezi Park protests in the summer of 2013 started as a peaceful citizens’ demonstration against the government’s plans to demolish a park in Istanbul city center in order to open space for the building of an Ottoman-themed mall and a new mosque, and after disproportionate police violence, turned into a mass movement against an increasingly authoritarian rule. The 2015 break-up of the Kurdish-Turkish peace process botched hopes for ending the 40-year conflict in the country’s Southeast. The failed coup in 2016 lead to ferocious crackdown on oppositional politicians, …

Sacred Architecture And Interreligious Dialogue In The Concept Of The “Russian World”, Oleksandr Lukyanenko

Occasional Papers on Religion in Eastern Europe

The article continues a series of studies illustrating the formation of the idea of the “Russian world” in the religious discourse of Orthodox Russia. The main attention is paid to ideological stamps used by Patriarch Kirill of Moscow during sermons and public speeches. The study summarizes the idea of the exclusivity of the Russian spiritual path in contrast to the West, which supports the annexation geopolitical policy of Vladimir Putin. The article provides examples of falsification of historical facts in the religious and political spheres in order to create a powerful propaganda background in the conditions of the Russian-Ukrainian war. …

Post-Soviet History Of Jehovah's Witnesses In Ukraine: From A Closed Sect To An Open Denomination, Vita Tytarenko, Liudmyla Fylypovych

Occasional Papers on Religion in Eastern Europe

This article considers the changes that have taken place in the Jehovah's Witnesses (JW) from the time of the USSR to today, when believers and their communities are having to fit into new historical circumstances. In peacetime JW occupied a relatively insignificant niche in the structure of religious life of Ukraine, overcoming the wary and sometimes openly negative attitude of the state, society, and other religious communities, formed by the Soviet regime. After 2014 JW are more and more confidently declaring their presence in Ukrainian society. Those who survived persecution and deportation during the Soviet era are regaining their rights …