Digital Commons Network^™

Optimized Parameters Fitting Of A Poro-Elastic Acoustic Model With Ultrasonic Measurements For The Monitoring Of Corroding Rebar In Reinforced Concrete, Samuel Shaffer

Electronic Theses and Dissertations 2020 - Present

Traditional techniques of observing cracking within reinforced structures can be invasive, leading to an increased risk of added corrosion to structures already undergoing corrosive processes. The research presented in this document improves upon a nondestructive method for detecting early crack formation in reinforced concrete. This method includes using acoustic signaling to add a layer of salt water between the sensor and analyzed sample. Following the collection of surface and rebar echo responses, an adapted version of the novel Biot-Stoll method is used to model sound propagation for poro-elastic mediums. Testing of model parameters and variables has improved the root mean …

Possible Morphological Advantages For Tolerating High Temperature And Humidity In A Subtropical Passerine (Peucaea Aestivalis), Billy Abbott

Electronic Theses and Dissertations 2020 - Present

Animals face both natural and sexual selection pressures, and at times, these pressures conflict with one another. This results in a tradeoff between sexual and natural selection. In my thesis, I examine aspects of Bachman’s sparrows’ behavior and morphology in relation to weather conditions in light of these two conflicting pressures. Large bill size is selected for by the natural selection pressures of thermoregulation. Smaller bills are selected for by the sexual selection pressures of song quality. Both thermoregulation and song are important behaviors/processes that have fitness implications. By looking at bill size in relation to thermoregulatory ability and song …

Porifera Biodiversity In The Indian River Lagoon: Evaluating The Latitudinal Ecotone And Similarities With Saint Lucie Reef, Greer Babbe

Electronic Theses and Dissertations 2020 - Present

Sponges (Phylum Porifera) are hardy organisms persisting and predicted to become more dominant world-wide under climate change scenarios. However, we lack baseline knowledge on sponge biodiversity in transitional areas (subtropical to warm-temperate) that are more susceptible to climate change such as The Indian River Lagoon (IRL) (estuary) and Saint Lucie Reef (northern most coral reef) ecosystems in south Florida. The aims of this master’s thesis are to 1) evaluate if sponge assemblages reflect the previously defined ecotone between subtropical and warm-temperate biomes in the IRL (Chapter one), 2) determine how porifera communities are associated to their respective environment (temperature, water …

Power Of The People: How Four Gubernatorial Candidates Capitalized On The Collective Identity Found In Social Movements, Gail L. Choate

Electronic Theses and Dissertations 2020 - Present

Gubernatorial mansions are historically home to white men. Candidates with contrary identities, such as women and racial minorities have met limited success in their quest for office. Yet the number of women seeking executive level office has increased and these women represent a broader intersectional identity. The low percentage of women governors has been examined in detail, but that analysis largely holds gender as an isolated variable and does not consider the candidates' broader identity. This project posits gender is only one factor of candidate identity called into question when it is nonnormative and varies from historical office holders. I …

Preference For Normative And Informational Social Influence In Evaluation Of Academic Integrity Violation Appeals, Lauren Olson

Electronic Theses and Dissertations 2020 - Present

Social influence is sought to distribute information processing for decision-making when data is limited. Undergraduate students selected information with normative or informational wording to supplement a fabricated academic integrity appeal from their university and decided whether to affirm the charge. A novel measure, the Adaptive Scale of Preference for Normative Versus Informational Social Influence (ASPNVISI), was piloted in comparison with a Polish scale of influence preference, individual difference measures in motivation (e.g., Need for Closure), and behavioral measures of influence-seeking. Results did not support the hypotheses that psychological needs would predict behavioral social influence preferences, though Need for Cognition and …

Reading Transness In Ai Narratives: How Artificiality Constructs Transgender Identity, Tristan Sheridan

Electronic Theses and Dissertations 2020 - Present

Transgender identity and the concept of artificial intelligence are constructed and understood through dichotomies such as natural/unnatural and real/artificial, with each dichotomy informing the other; what is “unnatural” is often deemed to be a mimicry of the “natural,” therefore a false representation of what is “real.” By surveying various classic SF texts and their portrayal of AI characters through the lens of transgender studies—drawing upon scholars including Susan Stryker, Sandy Stone, and Florence Ashley—I assert that artificiality itself is a construction formed by cisnormative ideals and standards to exclude certain others (namely, transgender people) that requires reframing. I examine how …

Self-Touch In Henry James's Major Phase, James Martin

Electronic Theses and Dissertations 2020 - Present

The three novels of Henry James’s “major phase” have alienated many readers in James’s own time and today. I draw on the philosophical school of phenomenology, in particular the work of Maurice Merleau-Ponty and a recent extension by the philosopher Richard Kearney, to suggest that a lack of self-touch by characters in these novels has contributed in a significant but previously unnoticed way to many readers’ sense that these novels feel frustratingly intangible. I make a comparison to the instances of self-touch in other Edwardian novels to underline the difference. I suggest that James is putting forward a model of …

Solving V.I. Arnold’S Problem About Asymptotic Enumeration Of Morse Functions On The 2-Sphere: A Combinatorial And Analytic Approach With Computer Assisted Proofs, Bishal Dhakal

Electronic Theses and Dissertations 2020 - Present

The goal of this dissertation is to estimate the precise asymptotics for the number of geometric equivalence classes of Morse functions on the 2-sphere. Our approach involves utilizing the Lagrange inversion formula, Cauchy’s coefficient formula, and the saddle point method for the asymptotic analysis of contour integrals to analyze the generating function derived by L. Nicolaescu, expressed as the inverse of an elliptic integral. We utilize complex analysis, nonlinear functional analysis in infinite sequence spaces, and interval arithmetic to write all the necessary MATLAB programs that validate our results. This work answers questions posed by Arnold and Nicolaescu, furthering our …

Social Media And Crime Analysis: The Intersection Of Online Posting And Law Enforcement Investigations, Kevin P. Lopez

Electronic Theses and Dissertations 2020 - Present

The current use of social media platforms has expanded to wider audiences, including police departments and other law enforcement agencies. The vast material being posted online may lead to it being used by police departments due to social media information being open-sourced. The following study will investigate the police’s use of social media data by collecting qualitative data from crime analysts through the International Association of Crime Analysts (IACA). Participants completed an openended survey describing their experience with collecting data from online social media sources and how it is used to assist with police activity. The results have implications for …

Singing Frogs, Wormy Interlopers, And Hungry Cannibals: An Investigation Of Complex Life Cycles And Multi Hostparasite Interactions, Sarah R. Goodnight

Electronic Theses and Dissertations 2020 - Present

Complex life cycles are common across parasite taxa and frequently require trophic transfer of parasites from prey to predator; however, studies on parasite-host interactions often neglect variation in parasite life histories. Here I use two focal freshwater digenetic trematode species, Halipegus occidualis tongueworms and Haematoloechus complexus lungworms, as an empirical system to investigate how parasite life history traits drive host-parasite interactions across the life cycle. To examine how parasite life history and host ecology influence parasite genetic patterns, I characterized the genetic diversity of within-host infrapopulations, as well as overall population genetic structure, of sympatric tongueworm and lungworm populations. Infection …

Distinct Temporal Trajectories And Risk Factors For Post-Acute Sequelae Of Sars-Cov-2 Infection, Chen Chen, Sairam Parthasarathy, Jacqueline M Leung, Michelle J Wu, Katherine A Drake, Vanessa K Ridaura, Howard C Zisser, William A Conrad, Victor F Tapson, James N Moy, Christopher R Defilippi, Ivan O Rosas, Bellur S Prabhakar, Mujeeb Basit, Mirella Salvatore, Jerry A Krishnan, Charles C Kim

Faculty, Staff and Students Publications

BACKGROUND: The understanding of Post-acute sequelae of SARS-CoV-2 infection (PASC) can be improved by longitudinal assessment of symptoms encompassing the acute illness period. To gain insight into the various disease trajectories of PASC, we assessed symptom evolution and clinical factors associated with the development of PASC over 3 months, starting with the acute illness period.

METHODS: We conducted a prospective cohort study to identify parameters associated with PASC. We performed cluster and case control analyses of clinical data, including symptomatology collected over 3 months following infection.

RESULTS: We identified three phenotypic clusters associated with PASC that could be characterized as …

Lymphangioleiomyomatosis: Circulating Levels Of Fgf23 And Pulmonary Diffusion, Anthony J Esposito, Jewel Imani, Shikshya Shrestha, Shefali Bagwe, Anthony M Lamattina, Marina Vivero, Hilary J Goldberg, Ivan O Rosas, Elizabeth P Henske, Souheil Y El-Chemaly

Faculty, Staff and Students Publications

OBJECTIVE: Lymphangioleiomyomatosis (LAM) is a rare, destructive disease of the lungs with a limited number of determinants of disease activity, which are a critical need for clinical trials. FGF23 has been implicated in several chronic pulmonary diseases. We aimed to determine the association between serum FGF23 levels and pulmonary function in a cohort of patients with LAM.

METHODS: This was a descriptive single-center study in which subjects with LAM and controls with unreported lung disease were recruited. Serum FGF23 levels were measured in all subjects. Clinical data, including pulmonary function testing, were retrospectively obtained from electronic medical records of LAM …

The Causal Role Of Theta Oscillations In The Frontoparietal Network On Cognitive Flexibility, Yosun Yoon

Electronic Theses and Dissertations 2020 - Present

Cognitive flexibility is crucial for efficient goal-directed behavior, especially in rapidly changing environments. While recent studies have consistently shown enhanced theta power and synchronization in the frontoparietal network during flexible task-switching, direct evidence establishing a causal link between theta-rhythm brain oscillation and cognitive flexibility remains limited. In this study, we applied transcranial alternating current stimulation (tACS) to the frontoparietal network at a theta frequency (6 Hz) with a phase difference of either 0° (inphase) or 180° (antiphase) to explore its impact on task-switching performance. The results showed no significant tACS modulation effects on switch costs or neural oscillatory synchronization in …

The Dynamic Ph Landscape At The Drosophila Nmj Synaptic Cleft And Its Implication In Neurotransmission, Roberto X. Hernandez

Electronic Theses and Dissertations 2020 - Present

The intricate processes governing cellular pH and its impact on protein and cellular function have been extensively explored. However, our understanding of the pH fluctuations that occur during routine cellular activities and their potential to modulate cell function remains, particularly within the highly dynamic pH landscape of a synapse. Investigating the scale, directionality, and temporal characteristics of these activity-dependent pH fluctuations at synapses is of paramount interest, as it carries profound implications for neurotransmitter release and signal transduction. Employing both empirical and computational modeling methods, our research explores the dynamic pH environment within the synaptic cleft of Drosophila glutamatergic motor …

The Influence Of Positively Evaluative Attributes On Purchasing Decisions, Chelsea L. Temples

Electronic Theses and Dissertations 2020 - Present

This experiment evaluated the effect of positively evaluative attributes on purchasing decisions by manipulating the Type of Repetition from a study phase to a test phase. Behavioral data and hemodynamic responses were measured using functional near-infrared spectroscopy (fNIRS) in 38 participants during a study task, where brand-name products and product specific attributes were processed, and during a test phase, where participants chose to purchase either new or previously processed products that were presented with either the same attribute, a different attribute, or no attribute. Results at test showed that repeating the association produced the highest accuracy in selecting the previously …

Synthesis And Biological Evaluation Of Β-Hairpin Peptides As Covalent Inhibitors Of The Pd-1/Pd-L1 Immune Checkpoint, Sarah Naylon

Electronic Theses and Dissertations 2020 - Present

Protein─protein interactions (PPIs) are essential for cell─cell interactions and cellular signal transduction, which play a crucial role in various human diseases. PPIs involved in cancer immunology pathways, known as immune checkpoints, have been intensely studied, leading to a new approach to cancer therapy. The PD1:PDL1 interaction is one of the most essential immune checkpoints. Studies on PD1:PDL1 showed over ten clinical monoclonal antibodies (mAb) used to treat cancer patients. Unfortunately, antibodies do not penetrate the tumor microenvironment well, and clearance from the body is slow, leading to unwanted side effects. There is a significant gap in the drug market between …

The Loose-Line Aesthetic: Visual Styles And Contemporary Fusion, Alex Henry

Electronic Theses and Dissertations 2020 - Present

Loose-line is a visual style where dramatic lines are created with quick, swift strokes, often randomly overlapping each other. Loose-lines can be used to depict a subject and emphasize its actions. They capture the viewer's attention and provide them with an understanding of the narrative depicted through its implication or suggestion of action. In this thesis I will examine, the loose-line technique and its components. I will show how loose-line has been used as a foundational technique for pre-visualizing painting, sculpture, and architecture throughout art history, and especially with regard to its role in the development of cinema and animation. …

The Relationship Between Skepticism And Knowledge And Accurate Diagnosis Of Dissociative Identity Disorder By Licensed Clinical Social Workers, Rochelle M. Epstein

Electronic Theses and Dissertations 2020 - Present

This study aimed to examine the relationship between licensed clinical social workers' (LCSWs) skepticism and knowledge about dissociative identity disorder (DID) and their accurate diagnosis of the disorder as moderated by specialized training about DID and/or postmaster’s experience with diagnosis and treatment of the disorder. The following research questions guided the study. • RQ1a. Is there a relationship between LCSWs’ level of skepticism and level of knowledge about DID. • RQ1b. Is there a relationship between LCSWs’ level of skepticism and accurate diagnosis of the disorder? • RQ1c. Is there a relationship between LCSWs’ level of knowledge about DID and …

The Sexual Lives Of Individuals With Disabilities: Attitudes From The General Public, Lauren Berlingo

Electronic Theses and Dissertations 2020 - Present

Sexual experiences and freedom are basic human rights that people with disabilities are often denied. Society and those considered to be within the general public, including caregivers, family members, and professionals that work with people with disabilities, contribute to the lack of sexual experiences and opportunities people with disabilities have throughout their lifetime. This study examined the attitudes of males and females from the general public toward sexual lives for people with disabilities. Further, it explored the difference in attitudes based on disability condition, examining attitudes toward a sexual life for those with a physical disability, intellectual disability, and general …

Timeline Of Nutrient Incorporation From Broodstock Diet To Egg In California Yellowtail, Seriola Dorsalis, Li Sun Chin

Electronic Theses and Dissertations 2020 - Present

Existing brood fish research has ascertained that eggs are heavily influenced by broodstock diet but there is no information regarding this timeline of nutritional incorporation. The objective of this study is to determine duration of nutritional incorporation from diet to eggs through fatty acids. Nine California Yellowtail (Seriola dorsalis) broodstock were fed alternating diets of commercial pellets (Vitalis PRIMA: Skretting) and cutbait. Biochemical and biometric data from spawns were collected and analyzed for differences and similarities throughout the alternating diets. Eggs were observed to selectively incorporate higher sources of linolenic and linoleic acid from the pelleted diet, and eicosapentaenoic acid …

Corrigendum: Alveolar Macrophages In Lung Cancer: Opportunities And Challenges, Cheng-Yen Chang, Dominique Armstrong, David B Corry, Farrah Kheradmand

Faculty, Staff and Students Publications

In the published article, there was an error in the article title. Instead of “Alveolar Macrophages in Lung Cancer: Opportunities Challenges”, it should be “Alveolar Macrophages in Lung Cancer: Opportunities and Challenges”.

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

Respiratory Function Changes As Early Signs Of Amyotrophic Lateral Sclerosis, Mario Polverino, Simone Sampaolo, Antonio Capuozzo, Marco Fasolino, Michele Aliberti, Ersilia Satta, Carlo Santoriello, James Peter Orengo, Francesca Polverino

Faculty, Staff and Students Publications

BACKGROUND: The current diagnostic criteria for amyotrophic lateral sclerosis (ALS) may remain unsatisfactory for months or years in the early disease. Pulmonary assessment has never been considered useful in the early diagnosis of ALS, and studies of pulmonary function in this patient category are lacking.

OBJECTIVES: The objective of this study was to assess the pulmonary function in subjects with unspecific symptoms of ALS in whom an ALS diagnosis cannot be reached based on the current available guidelines.

METHODS: We performed pulmonary function tests, arterial gas analysis, maximal inspiratory (MIP) and expiratory (MEP) pressure, and respiratory drive (P0.1) assessment in …

Understanding Bubble Growth Behavior During Nucleate Boiling, Mahyar Ghazvini

Electronic Theses and Dissertations 2020 - Present

Boiling heat transfer associated with bubble growth is perhaps one of the most efficient cooling methodologies due to its sizeable latent heat during phase change. Despite significant advancement, numerous questions remain regarding the fundamentals of bubble growth mechanisms, a primary source of enhanced heat dissipation. This thesis provides a comprehensive examination of the mechanisms involved in the growth of bubbles during nucleate boiling. By conducting a combination of experiments and numerical analyses, the goal is to enhance our understanding of bubble growth phenomena and their impact on heat transfer. Initially, the experimental work focuses on comparing the heat transfer performance …

Using An Instructional Package To Support Adults With Autism In Communicating With A Medical Provider, Jacqueline M. Wood

Electronic Theses and Dissertations 2020 - Present

Adults with autism spectrum disorder (ASD) often experience co-occurring physical and mental health challenges throughout their lives. At the same time, they often face many barriers to accessing proper care. Strategies to improve communication and understanding can help to mitigate some of these barriers. This study examined the effects of an instructional package, including a video module accompanied by guided notes, the Autism Healthcare Accommodations Tool (AHAT), and behavior skills training (BST) to teach adults with autism to communicate their unique needs and request accommodations from a medical provider. Participants completed a self-guided video module that guided them through the …

Integrative Metabolomics And Transcriptomics Analysis Reveals Novel Therapeutic Vulnerabilities In Lung Cancer, Jose Thaiparambil, Jianrong Dong, Sandra L Grimm, Dimuthu Perera, Chandra Shekar R Ambati, Vasanta Putluri, Matthew J Robertson, Tajhal D Patel, Brandon Mistretta, Preethi H Gunaratne, Min P Kim, Jason T Yustein, Nagireddy Putluri, Cristian Coarfa, Randa El-Zein

Faculty, Staff and Students Publications

BACKGROUND: Non-small cell lung cancer (NSCLC) comprises the majority (~85%) of all lung tumors, with lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) being the most frequently diagnosed histological subtypes. Multi-modal omics profiling has been carried out in NSCLC, but no studies have yet reported a unique metabolite-related gene signature and altered metabolic pathways associated with LUAD and LUSC.

METHODS: We integrated transcriptomics and metabolomics to analyze 30 human lung tumors and adjacent noncancerous tissues. Differential co-expression was used to identify modules of metabolites that were altered between normal and tumor.

RESULTS: We identified unique metabolite-related gene signatures specific for …

Is It Time To Switch To Bivalirudin For Ecmo Anticoagulation?, Amir Navaei, Vadim Kostousov, Jun Teruya

Faculty, Staff and Students Publications

For decades, unfractionated heparin (hereafter, heparin) has been the primary anticoagulant used for extracorporeal membrane oxygenation (ECMO) support. More recently, however, bivalirudin, a direct thrombin inhibitor, has emerged as an alternative. This systematic review based on PRISMA guidelines, aims to summarize 16 comparative studies and 8 meta-analysis and review articles published from January, 2011 till May, 2023 which directly compares ECMO courses using heparin versus bivalirudin as the anticoagulant. While this comparison is complicated by the lack of a standardized definition of major bleeding or thrombosis, our overall findings suggest there is no statistical difference between heparin and bivalirudin in …

Intermel: An International Biorepository And Clinical Database To Uncover Predictors Of Survival In Early-Stage Melanoma, Irene Orlow, Keimya D Sadeghi, Sharon N Edmiston, Jessica M Kenney, Cecilia Lezcano, James S Wilmott, Anne E Cust, Richard A Scolyer, Graham J Mann, Tim K Lee, Hazel Burke, Valerie Jakrot, Ping Shang, Peter M Ferguson, Tawny W Boyce, Jennifer S Ko, Peter Ngo, Pauline Funchain, Judy R Rees, Kelli O'Connell, Honglin Hao, Eloise Parrish, Kathleen Conway, Paul B Googe, David W Ollila, Stergios J Moschos, Eva Hernando, Douglas Hanniford, Diana Argibay, Christopher I Amos, Jeffrey E Lee, Iman Osman, Li Luo, Pei-Fen Kuan, Arshi Aurora, Bonnie E Gould Rothberg, Marcus W Bosenberg, Meg R Gerstenblith, Cheryl Thompson, Paul N Bogner, Ivan P Gorlov, Sheri L Holmen, Elise K Brunsgaard, Yvonne M Saenger, Ronglai Shen, Venkatraman Seshan, Eduardo Nagore, Marc S Ernstoff, Klaus J Busam, Colin B Begg, Nancy E Thomas, Marianne Berwick, Intermel Consortium

Faculty, Staff and Students Publications

INTRODUCTION: We are conducting a multicenter study to identify classifiers predictive of disease-specific survival in patients with primary melanomas. Here we delineate the unique aspects, challenges, and best practices for optimizing a study of generally small-sized pigmented tumor samples including primary melanomas of at least 1.05mm from AJTCC TNM stage IIA-IIID patients. We also evaluated tissue-derived predictors of extracted nucleic acids' quality and success in downstream testing. This ongoing study will target 1,000 melanomas within the international InterMEL consortium.

METHODS: Following a pre-established protocol, participating centers ship formalin-fixed paraffin embedded (FFPE) tissue sections to Memorial Sloan Kettering Cancer Center for …

Reward Sensitivity Predicts The Response To Cognitive Behavioral Therapy For Children With Autism And Anxiety, Matthew J Hollocks, Jeffrey J Wood, Eric A Storch, An-Chuen Cho, Connor M Kerns, Philip C Kendall

Faculty, Staff and Students Publications

Objective: Cognitive-behavioral therapy (CBT) is an effective treatment for anxiety in youth with autism spectrum disorder (ASD). However, research has yet to examine what cognitive characteristics may influence treatment response. The current study investigated decision-making ability and social cognition as potential (a) predictors of differential treatment response to two versions of CBT and (b) moderators of the effect of treatment condition.

Method: The study included 148 children (mean age = 9.8 years) with interfering anxiety and a diagnosis of ASD who were enrolled in a randomized clinical trial comparing two versions of CBT for anxiety (standard and adapted for ASD). …

A Design Concept For Launch And Recovery Of Remus 100 Auv From Wam-V 16 Usv, Brendan Palmaccio

Electronic Theses and Dissertations 2020 - Present

In this thesis, feasibility of a concept for launch and recovery of the Remus AUV from WAM-V USV is investigated. A modular recovery system which can be added to the WAM-V payload tray was designed, and based on a review of previous literature a CONOPS was developed for the launch and recovery process. The first phase of the CONOPS, which pertains to the position of the REMUS initially on the free surface prior to sling engagement is simulated using ANSYS AQWA. Preprocessing for the simulation involved simplification of the model in ANSYS SpaceClaim to achieve a proper mesh as well …

A New Mechanical And Radiation Isocenter Adjustment Approach Using The Isopoint, Tristan Irons

Electronic Theses and Dissertations 2020 - Present

The Winston-Lutz has been the standard test for isocenter convergence, however, any adjustments needed – in case the test fails – are time consuming since the source of error is not readily available from the results. Isopoint by the Aktina Medical company has been developed to address this problem via decoupling the mechanical from the radiation isocenter and providing the user with information that was inaccessible before. The focus of this research is to perform optimization of the isocenter by using the Isopoint and to confirm the validity of its results, as well as to find how much time is …