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2023

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Association Of Igg N-Glycomics With Prevalent And Incident Type 2 Diabetes Mellitus From The Paradigm Of Predictive, Preventive, And Personalized Medicine Standpoint, Xiaoni Meng, Fei Wang, Xiangyang Gao, Biyan Wang, Xizhu Xu, Youxin Wang, Wei Wang, Qiang Zeng Jan 2023

Association Of Igg N-Glycomics With Prevalent And Incident Type 2 Diabetes Mellitus From The Paradigm Of Predictive, Preventive, And Personalized Medicine Standpoint, Xiaoni Meng, Fei Wang, Xiangyang Gao, Biyan Wang, Xizhu Xu, Youxin Wang, Wei Wang, Qiang Zeng

Research outputs 2022 to 2026

Objectives: Type 2 diabetes mellitus (T2DM), a major metabolic disorder, is expanding at a rapidly rising worldwide prevalence and has emerged as one of the most common chronic diseases. Suboptimal health status (SHS) is considered a reversible intermediate state between health and diagnosable disease. We hypothesized that the time frame between the onset of SHS and the clinical manifestation of T2DM is the operational area for the application of reliable risk assessment tools, such as immunoglobulin G (IgG) N-glycans. From the viewpoint of predictive, preventive, and personalized medicine (PPPM/3PM), the early detection of SHS and dynamic monitoring by glycan biomarkers …


Blockchain And Sustainability Disclosure: A Scenario-Based Application For Supply Chains, Laura Corazza, Junru Zhang, Dilhani Kapu Arachchilage, Simone Domenico Scagnelli Jan 2023

Blockchain And Sustainability Disclosure: A Scenario-Based Application For Supply Chains, Laura Corazza, Junru Zhang, Dilhani Kapu Arachchilage, Simone Domenico Scagnelli

Research outputs 2022 to 2026

This paper presents the implications of blockchain technologies on sustainability reporting and disclosure, and specifically proposes blockchain use-cases as a possible solution for problems experienced in the field of supply chain carbon information. This study addresses how the reliability of supply chains’ carbon-related information can become more transparent and reliable through a decentralized approach based on blockchain thinking (BT), issues that have been identified as a gap in the literature and in the practice. Scenario analysis and design science research (DSR) are used as a methodological driver to conceptualize over the nature of practical solutions using unified modeling language (UML) …


Improved Rate Of Secret Key Generation Using Passive Re-Configurable Intelligent Surfaces For Vehicular Networks, Hina Ayaz, Muhammad Waqas, Ghulam Abbas, Ziaul Haq Abbas, Muhammad Bilal, Kyung-Sup Kwak Jan 2023

Improved Rate Of Secret Key Generation Using Passive Re-Configurable Intelligent Surfaces For Vehicular Networks, Hina Ayaz, Muhammad Waqas, Ghulam Abbas, Ziaul Haq Abbas, Muhammad Bilal, Kyung-Sup Kwak

Research outputs 2022 to 2026

The reconfigurable intelligent surfaces (RIS) is a new technology that can be utilized to provide security to vehicle-to-vehicle (V2V) communications at the physical layer. In this paper, we achieve a higher key generation rate for V2V communications at lower cost and computational complexity. We investigate the use of a passive RIS as a relay, to introduce channel diversity and increase the key generation rate (KGR), accordingly. In this regard, we consider the subsets of consecutive reflecting elements instead of the RIS as a whole in a time slot, i.e., instead of a single reflector, the subsets of reflectors are utilized …


Authentic Leadership And Psychological Well-Being Of Nurses: A Mediated Moderation Model, Stephen Teo, Andrei Lux, David Pick Jan 2023

Authentic Leadership And Psychological Well-Being Of Nurses: A Mediated Moderation Model, Stephen Teo, Andrei Lux, David Pick

Research outputs 2022 to 2026

Aims. This study investigates how authentic leadership influences the psychological well-being of Australian nurses. We examined whether authentic leadership could reduce the prevalence of workplace incivility and tested whether shared values and person-organization (P-O) fit could moderate the relationship between workplace incivility and psychological well-being (PWB). A mediated moderation model underpinned by social learning theory was developed to test the influence of authentic leadership on PWB.

Design. We adopted a descriptive correlational research design to test the hypothesized model with a cross-sectional sample of Australian nurses using an online survey. Data were collected across two-waves separated by a …


Summary Of Alcohol And Drug Treatment For Aboriginal And Torres Strait Islander Peoples, Australian Indigenous Healthinfonet Jan 2023

Summary Of Alcohol And Drug Treatment For Aboriginal And Torres Strait Islander Peoples, Australian Indigenous Healthinfonet

Research outputs 2022 to 2026

This summary is based on the Review of alcohol and drug treatment for Aboriginal and Torres Strait Islander peoples. It provides an overview of the available evidence for treatment approaches to help a person reduce or stop substance use. These are treatments for when a person has evidence of either hazardous use or problem alcohol and other drug (AOD) use (see Box 1 for terms used). Some approaches to address substance use are not included in this summary (e.g. for tobacco cessation or volatile substance use). This summary presents information on:

• the available research and other evidence that underpins …


From Real Life To Story – And Back Again: Using Autobiographical Fiction Writing To Understand Self, Others And Family Generations, Alberta N. Adji Jan 2023

From Real Life To Story – And Back Again: Using Autobiographical Fiction Writing To Understand Self, Others And Family Generations, Alberta N. Adji

Research outputs 2022 to 2026

Writing autobiographically includes complicated responsibilities to the subjects involved: to family members, friends, colleagues, and even cultural communities. This article explores creative developments occurring during the process of writing an autobiographical novel called ‘The longing’, which is drawn from a recollection of intergenerational lived experiences of a middle-class Chinese Indonesian family from 1956 to 2018. I reflect on my strategies and approaches on tackling challenges that arose while using autobiographical material and autofictional techniques to write fiction and communicating cultural complexities for it allows agreeable distance between the author and her writing subject. In the article, I also argue that …


Responsive, Adaptive, And Future-Centred Leadership In Response To Crisis: Findings From Australia, Fiji, And New Zealand, Michelle Striepe, Pauline Thompson, Sylvia Robertson, Mohini Devi, David Gurr, Fiona Longmuir, Adam Taylor, Christine Cunningham Jan 2023

Responsive, Adaptive, And Future-Centred Leadership In Response To Crisis: Findings From Australia, Fiji, And New Zealand, Michelle Striepe, Pauline Thompson, Sylvia Robertson, Mohini Devi, David Gurr, Fiona Longmuir, Adam Taylor, Christine Cunningham

Research outputs 2022 to 2026

The COVID-19 pandemic has caused major disruption to education and highlighted the importance of effective leadership during times of crisis. This paper considers the impact of the pandemic on school leaders in Australia, Fiji, and New Zealand. A secondary analysis of data from five interpretivist, qualitative studies was conducted. The aim of the study was to investigate the similarities and differences between the leaders’ experiences across school settings, states/provinces, and countries. Our findings place renewed importance on understanding the role of schools within the community and the vital role school leaders play in helping schools respond to volatile and dynamic …


A New Augmented Reality System For Calculating Social Distancing Between Children At School, Omar Alshaweesh, Mohammad Wedyan, Moutaz Alazab, Bilal Abu-Salih, Adel Al-Jumaily Jan 2023

A New Augmented Reality System For Calculating Social Distancing Between Children At School, Omar Alshaweesh, Mohammad Wedyan, Moutaz Alazab, Bilal Abu-Salih, Adel Al-Jumaily

Research outputs 2022 to 2026

Social distancing is one of the most important ways to prevent many diseases, especially the respiratory system, where the latest internationally spread is coronavirus disease, and it will not be the last. The spreading of this pandemic has become a major threat to human life, especially to the elderly and people suffering from chronic diseases. During the Corona pandemic, medical authorities were keen to control the spread through social distancing and monitoring it in markets, universities, and schools. This monitoring was mostly used to estimate the distance with the naked eye and interfere with estimating the distance on the observer …


Educational Leaders’ Perceptions Of Stem Education Revealed By Their Drawings And Texts, Vesife Hatisaru, Garry Falloon, Andrew Seen, Sharon Fraser, Markus Powling, Kim Beswick Jan 2023

Educational Leaders’ Perceptions Of Stem Education Revealed By Their Drawings And Texts, Vesife Hatisaru, Garry Falloon, Andrew Seen, Sharon Fraser, Markus Powling, Kim Beswick

Research outputs 2022 to 2026

This study explored school principals' and teacher educators' perceptions of STEM education based on how they described STEM as a discipline, their understanding of the nature of teaching and learning of STEM, and the capabilities of a STEM-educated person. Data were generated through the Draw a STEM Learning Environment (D-STEM) instrument comprising drawn and written descriptions where participants drew a picture of a STEM learning environment and completed five prompt statements about what STEM is and how an individual develops personal STEM capability. The Legitimation Code Theory (LCT) specialization codes were used for data analysis (198 individual response items in …


Exploring The Use Of Photovoice In Understanding The Lived Experience Of Neurological Conditions: A Scoping Review And Reflexive Thematic Analysis, James Smith, Andre Nels, Laura Emery, Mandy Stanley Jan 2023

Exploring The Use Of Photovoice In Understanding The Lived Experience Of Neurological Conditions: A Scoping Review And Reflexive Thematic Analysis, James Smith, Andre Nels, Laura Emery, Mandy Stanley

Research outputs 2022 to 2026

People living with neurological conditions such as multiple sclerosis, Parkinson’s disease and dementia may experience physical impairment, social disengagement, cognitive issues, and emotional disturbances. While qualitative research utilising in-depth interviews can access lived experience perspectives, the use of photovoice has the potential to obtain rich insights that include images and raise community awareness. The purpose of this scoping review was to document salient themes relating to the lived experience of neurological conditions as reported in photovoice studies. Following established scoping review methods of the Joanna Briggs Institute, a comprehensive search of five electronic databases, including MEDLINE, EMBASE, PSYCHINFO, CINAHL, and …


Re-Expatriation Inclinations Among Skilled Female Self-Initiated Repatriates In Asia's Rapidly Emerging Markets, Nga T. T. Ho, Pi-Shen Seet, Janice Jones, Hung T. Hoang Jan 2023

Re-Expatriation Inclinations Among Skilled Female Self-Initiated Repatriates In Asia's Rapidly Emerging Markets, Nga T. T. Ho, Pi-Shen Seet, Janice Jones, Hung T. Hoang

Research outputs 2022 to 2026

Purpose: Integrating identity theory and role theory, this study examines the re-expatriation inclinations of highly-skilled professional female self-initiated repatriates (SIRs) in an Asian rapidly emerging market (REM) and the reasons underlying these inclinations.

Design/methodology/approach: The authors conducted a survey on a sample of highly-skilled professional female SIRs in Vietnam (N = 248). Structural equation modelling was used to evaluate the model.

Findings: The study found that female SIRs' career identity, family identity and social identity have a significant influence on their inclinations to re-expatriate. Attitude towards re-expatriation fully mediates the influence of family identity and career identity on re-expatriation …


A Review Of Cyber Vigilance Tasks For Network Defense, Oliver A. Guidetti, Craig Speelman, Peter Bouhlas Jan 2023

A Review Of Cyber Vigilance Tasks For Network Defense, Oliver A. Guidetti, Craig Speelman, Peter Bouhlas

Research outputs 2022 to 2026

The capacity to sustain attention to virtual threat landscapes has led cyber security to emerge as a new and novel domain for vigilance research. However, unlike classic domains, such as driving and air traffic control and baggage security, very few vigilance tasks exist for the cyber security domain. Four essential challenges that must be overcome in the development of a modern, validated cyber vigilance task are extracted from this review of existent platforms that can be found in the literature. Firstly, it can be difficult for researchers to access confidential cyber security systems and personnel. Secondly, network defense is vastly …


Careful And Curious: A Transformative Ethos For Artistic Evaluation, Vahri Mckenzie, Denise Thwaites, Cathy Hope Jan 2023

Careful And Curious: A Transformative Ethos For Artistic Evaluation, Vahri Mckenzie, Denise Thwaites, Cathy Hope

Research outputs 2022 to 2026

The logic of government subsidy recognises that there are forms of value not suitably captured by exchanges of the free market. Yet there remains a growing impetus for arts organisations and individual artists to measure and articulate the specific value of their practices through formal processes of evaluation. In the context of government subsidy, evaluation typically misses opportunities to capture unforeseen insights that artists and communities may articulate through alternative forms of evaluation. This article offers a conceptual discussion and illustrative example of how more open and exploratory evaluation methodologies may intersect with existing government frameworks. We draw on the …


Developing A Resource For Arts Educators To Enhance The Social And Emotional Well-Being Of Young People, Leanne Fried, Christine Lovering, Sarah Falconer, Jacinta Francis, Robyn Johnston, Karen Lombardi, Kevin Runions, Karen Forde, Naomi Crosby, Lilly Blue Jan 2023

Developing A Resource For Arts Educators To Enhance The Social And Emotional Well-Being Of Young People, Leanne Fried, Christine Lovering, Sarah Falconer, Jacinta Francis, Robyn Johnston, Karen Lombardi, Kevin Runions, Karen Forde, Naomi Crosby, Lilly Blue

Research outputs 2022 to 2026

Background: Mental health concerns prevent positive well-being and are key challenges for Australian children and young people. Arts organisations play a role in enhancing the positive mental health of children and young people. This paper describes the involvement of young people and their parents in the development of a resource for arts organisation’s intentional support of social and emotional well-being. Methods: Six focus groups were conducted with 19 young people who participate in dance, drama, and circus programs, and 17 of their parents. Questions explored how the arts currently, and potentially, support their social and emotional well-being. Results: Three overarching …


Virtual Reality And Serious Gaming In Re-Engineering Clinical Teaching: A Review Of Literature Of The Experiences And Perspectives Of Clinical Trainers, Lucy W. Kivuti-Bitok, Joyce J. Cheptum, Mariana Mutwiri, Susan Wanja, Irene Ngune Jan 2023

Virtual Reality And Serious Gaming In Re-Engineering Clinical Teaching: A Review Of Literature Of The Experiences And Perspectives Of Clinical Trainers, Lucy W. Kivuti-Bitok, Joyce J. Cheptum, Mariana Mutwiri, Susan Wanja, Irene Ngune

Research outputs 2022 to 2026

Re-engineer clinical teaching through innovative approaches such as virtual reality (VR) and Serious Gaming (SG) may increase patient safety. While several studies have focused on the experiences and perceptions of learners about VR and SG, few have if any have focused on the instructors. We reviewed and appraised published evidence to establish the experiences and intention to adopt VR and SG in clinical teaching. Relevant articles were sourced from five databases (PubMed/Medline, Informit, +A Education, ProQuest-ERIC, and CINHAL-EBSCO host). Experiences of clinical trainers were reported using the technological, pedagogical, and content knowledge (TPACK) model. The intention to adopt VR and …


Volume 50, Issue 1 (2023) Jan 2023

Volume 50, Issue 1 (2023)

The Journal of Sociology & Social Welfare

No abstract provided.


Teaching Beyond Trans-Competency: Exploring Trans-Affirming Pedagogy Through Applied Case Studies, Sam Harrell, Sarah Mountz, Hazel (Bobbi) Ali Zaman Jan 2023

Teaching Beyond Trans-Competency: Exploring Trans-Affirming Pedagogy Through Applied Case Studies, Sam Harrell, Sarah Mountz, Hazel (Bobbi) Ali Zaman

The Journal of Sociology & Social Welfare

In this paper, we share two applied case studies social work instructors can use to teach trans-affirming, anti-oppressive practice. These cases span two practice arenas, child welfare and low-barrier shelter services, and are derived from practice in the authors’ personal and professional experiences in the Northeastern and Midwestern regions of the United States. For each case, we describe the accompanying class context, share our pedagogical approach, name the underlying assumptions and structures that facilitate harm, explore relevant practice skills, and identify theoretical, philosophical, and ethical commitments essential for trans-affirming practice. Our approach to social work education on transgender and gender …


Racial Microaggressions And Asian Americans' Well-Being: A Scoping Review And Exploratory Meta-Analysis, Shinwoo Choi, Amy Alberton, Hyejoon Park, Eun-Jee Song, Heather Gough, Inyoung Stella Lee Jan 2023

Racial Microaggressions And Asian Americans' Well-Being: A Scoping Review And Exploratory Meta-Analysis, Shinwoo Choi, Amy Alberton, Hyejoon Park, Eun-Jee Song, Heather Gough, Inyoung Stella Lee

The Journal of Sociology & Social Welfare

BACKGROUND: Racial microaggressions continue to be a serious problem in the United States. While racialized microaggressions have been a long standing, though under explored, issue for all Asian Americans, Covid significantly amplified both overt and microaggression-based discrimination against Asian Americans because of the links between the origins of the viral spread and China (Lee & Waters, 2021). Despite this history of discrimination against Asian Americans, research in the area of microaggressions has lagged compared to other groups. However, research in this area has recently grown significantly, warranting a synthetic study of existing literature in order to better frame understandings of …


When Contraceptive Means No Pregnancy: Narrative Account Of Contraceptive Use Among Reproductive Women At The Tamale Teaching Hospital, Ghana, Akosua Bonsu Karikari, Nana Afia Karikari, Akua Afriyie Karikari, Amos Apraku Jan 2023

When Contraceptive Means No Pregnancy: Narrative Account Of Contraceptive Use Among Reproductive Women At The Tamale Teaching Hospital, Ghana, Akosua Bonsu Karikari, Nana Afia Karikari, Akua Afriyie Karikari, Amos Apraku

The Journal of Sociology & Social Welfare

Contraception is a major intervention in improving maternal health. There are about 214 million women of reproductive age in developing countries who are not using modern contraception to prevent pregnancy. For proper locale-specific analysis of female reproductive health issues in Ghana, it is vital to explore the knowledge base and hindrances to contraception use in local communities. We used a phenomenological design to study reproductive- aged women in the Tamale Metropolis of the Northern Region of Ghana in order to comprehend the life world of study participants. This research demonstrates that the majority of the women in the study area …


Examining The Early Impact Of The Covid-19 Pandemic On Black/African American Adults, Laurie Blackman, Kathryn S. Krase, Donna Wang, Anthony C. Hill, Megan Cambridge Jan 2023

Examining The Early Impact Of The Covid-19 Pandemic On Black/African American Adults, Laurie Blackman, Kathryn S. Krase, Donna Wang, Anthony C. Hill, Megan Cambridge

The Journal of Sociology & Social Welfare

The COVID-19 pandemic revealed a disproportionate risk of the disease in communities of color. The present study explored the impact of the early days of the COVID-19 pandemic on self-reported adaptation and coping, compared by the race of the respondent. Results from an anonymous, cross-sectional, online survey administered in June 2020 found that Black/African American adult respondents were less likely than non- Black/African American adult respondents to agree that they felt prepared for the COVID-19 outbreak; they were more likely than non- Black/African American adults to agree that they were personally affected by the COVID-19 outbreak, and more likely to …


The Myth Of Programmatic Intervention To Tackle Intergenerational Poverty In Post-Industrial Societies: A Longitudinal Study In Hong Kong As A Vantage Point, Wing Chung Ho Jan 2023

The Myth Of Programmatic Intervention To Tackle Intergenerational Poverty In Post-Industrial Societies: A Longitudinal Study In Hong Kong As A Vantage Point, Wing Chung Ho

The Journal of Sociology & Social Welfare

Through tracking the educational and career trajectories of the young adult members (aged 24–26) of 154 families over 13–15 years, this study suggests that the problem of intergenerational poverty is serious in Hong Kong. Quantitative data indicates that adolescents with poor parents have a 104 percent higher chance of being poor in young adulthood, and nearly 60 percent (58.4%) of the samples follow “the-poor-begets-the-poor; therich- begets-the-rich” pattern across generations. However, the explanatory power of the logistic regression models consisting of confounding factors are weak (R2=0.15). Subsequent focus group discussions with 30 mothers from the samples point to myriad forms of …


The Magnetic Pull Of American Discovery: Second Thoughts About American Exceptionalism?, Richard L. Marcus Jan 2023

The Magnetic Pull Of American Discovery: Second Thoughts About American Exceptionalism?, Richard L. Marcus

Faculty Scholarship

No abstract provided.


Vaccination Mandates—An Old Public Health Tool Faces New Challenges, Dorit Rubenstein Reiss, Lawrence O. Gostin, Michelle M. Mello Jan 2023

Vaccination Mandates—An Old Public Health Tool Faces New Challenges, Dorit Rubenstein Reiss, Lawrence O. Gostin, Michelle M. Mello

Faculty Scholarship

No abstract provided.


Misinformation And Covid-19, Dorit Rubenstein Reiss Jan 2023

Misinformation And Covid-19, Dorit Rubenstein Reiss

Faculty Scholarship

The COVID-19 pandemic’s impact on our world cannot be overstated. One of its noticeable features was the prominence of misinformation generally, and anti-vaccine misinformation more specifically. This article provides a breakdown of the five major themes of antivaccine misinformation and the way they were used to create fear, uncertainty, and doubt about COVID- 19 vaccines. Long before the pandemic, anti-vaccine activists argued using a five-part playbook. They argued that (1) vaccine preventable diseases were not really dangerous, (2) vaccines were dangerous and ineffective, (3) there were alternative treatments that were better than (dangerous and ineffective) vaccines, (4) there was a …


The Uncertain Future Of Restorative Justice: Anti-Woke Legislation, Retrenchment And Politics Of The Right, Thalia Gonzalez, Mara Schiff Jan 2023

The Uncertain Future Of Restorative Justice: Anti-Woke Legislation, Retrenchment And Politics Of The Right, Thalia Gonzalez, Mara Schiff

Faculty Scholarship

As diverse forms of anti-democratic and anti-inclusionary politics escalate in the United States, public education is increasingly a site for retrenchment and contestation with targeted efforts to silence and erase civil rights victories for equity and access. Addressing a critical, yet unattended issue at the intersection of education law and policy and civil rights, this Article joins with the growing discourse interrogating the “parental rights” movement and racially regressive legislation. Employing a case study analysis of social movement activism and education policy legislation from 2018–2023 in Florida, it aims to provoke critical praxis emanating from essential inquiry— what is the …


Rights Violations As Punishment, Kate Weisburd Jan 2023

Rights Violations As Punishment, Kate Weisburd

Faculty Scholarship

Is punishment generally exempt from the Constitution? That is, can the deprivation of basic constitutional rights—such as the rights to marry, bear children, worship, consult a lawyer, and protest—be imposed as direct punishment for a crime and in lieu of prison, so long as such intrusions are not “cruel and unusual” under the Eighth Amendment? On one hand, such state intrusion on fundamental rights would seem unconstitutional. On the other hand, such intrusions are often less harsh than the restriction of rights inherent in prison. If a judge can sentence someone to life in prison, how can a judge not …


Designing For Circularity: Sustainable Pathways For Australian Fashion Small To Medium Enterprises, Lisa Westover Piller Jan 2023

Designing For Circularity: Sustainable Pathways For Australian Fashion Small To Medium Enterprises, Lisa Westover Piller

Research outputs 2022 to 2026

Purpose: Australians consume twice the global average of textiles and are deeply engaged in a linear take/make/waste fashion model. Furthermore the Australian fashion sector has some unique supply chain complications of geographical distances, sparse population and fragmentation in processing and manufacturing. This research aims to examine how Australian fashion small to medium enterprises (SMEs) are overcoming these challenges to run fashion businesses built around core principles of product stewardship (PS) and circularity.

Design/methodology/approach: SMEs make up 88% of the Australian apparel manufacturing sector. This qualitative exploratory study included in-depth interviews with three Australian fashion SMEs engaged in circular design practice, …


January 2023 News Releases, University Of Montana--Missoula. Office Of University Relations Jan 2023

January 2023 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.


Characteristics Of Type 2 Diabetes In Female And Male Youth, Beatriz Castillo Rodriguez, Marcela Astudillo, Mustafa Tosur, Ahmad Rafaey, Siripoom Mckay, Fida Bacha, Ashok Balasubramanyam, Maria J Redondo Jan 2023

Characteristics Of Type 2 Diabetes In Female And Male Youth, Beatriz Castillo Rodriguez, Marcela Astudillo, Mustafa Tosur, Ahmad Rafaey, Siripoom Mckay, Fida Bacha, Ashok Balasubramanyam, Maria J Redondo

Faculty, Staff and Students Publications

The incidence of type 2 diabetes in children is rising and carries a worse prognosis than in adults. The influence of sex on pediatric type 2 diabetes outcomes has not been well investigated. We studied 715 youth with type 2 diabetes diagnosed at a median age of 13.7 years and compared sex differences in demographic, clinical, and laboratory characteristics within the first year of diagnosis. Females diagnosed with type 2 diabetes were younger and at a higher stage of pubertal development than males, yet presented with lower A1Cs, a lower prevalence of diabetic ketoacidosis, and higher HDL cholesterol levels.


Insulin-Like Growth Factor 1 Supplementation Supports Motor Coordination And Affects Myelination In Preterm Pigs, Line I Christiansen, Gemma C Ventura, Bo Holmqvist, Karoline Aasmul-Olsen, Sandy E H Lindholm, Matthew D Lycas, Yuki Mori, Jan Bojsen-Møller Secher, Douglas G Burrin, Thomas Thymann, Per T Sangild, Stanislava Pankratova Jan 2023

Insulin-Like Growth Factor 1 Supplementation Supports Motor Coordination And Affects Myelination In Preterm Pigs, Line I Christiansen, Gemma C Ventura, Bo Holmqvist, Karoline Aasmul-Olsen, Sandy E H Lindholm, Matthew D Lycas, Yuki Mori, Jan Bojsen-Møller Secher, Douglas G Burrin, Thomas Thymann, Per T Sangild, Stanislava Pankratova

Faculty, Staff and Students Publications

INTRODUCTION: Preterm infants have increased risk of impaired neurodevelopment to which reduced systemic levels of insulin-like growth factor 1 (IGF-1) in the weeks after birth may play a role. Hence, we hypothesized that postnatal IGF-1 supplementation would improve brain development in preterm pigs, used as a model for preterm infants.

METHODS: Preterm pigs delivered by cesarean section received recombinant human IGF-1/IGF binding protein-3 complex (rhIGF-1/rhIGFBP-3, 2.25 mg/kg/day) or vehicle from birth to postnatal day 19. Motor function and cognition were assessed by monitoring of in-cage and open field activities, balance beam test, gait parameters, novel object recognition and operant conditioning …