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2023

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New Lidar System Pinpoints Pedestrian Behavior To Improve Eficiency And Safety At Intersections, Taylor Li, Sirisha M. Kothuri, Xianfeng Terry Yang Jan 2023

New Lidar System Pinpoints Pedestrian Behavior To Improve Eficiency And Safety At Intersections, Taylor Li, Sirisha M. Kothuri, Xianfeng Terry Yang

TREC Project Briefs

Pedestrian safety is critical to improving walkability in cities. To that end, NITC researchers have developed a system for collecting pedestrian behavior data using LiDAR sensors. Tested at two intersections in Texas and soon to be tested at another in Salt Lake City, Utah, the new software created by a multi-university research team is able to reliably observe pedestrian behavior and can help reduce conflicts between pedestrians and vehicles at signalized intersections. The Utah Department of Transportation (UDOT) is already working on implementing this new LiDAR system to improve data collection at intersections.


Unexpected Wins: Curating Comics And Teaching Manga From The Dark Horse Comics Collection, Elsa Loftis, Jon Holt Jan 2023

Unexpected Wins: Curating Comics And Teaching Manga From The Dark Horse Comics Collection, Elsa Loftis, Jon Holt

Library Faculty and Staff Publications and Presentations

A familiar staple of entertainment for a wide variety of readers, the comic book has not always held a regular place in the academic library. Concerning themselves with collecting more traditional expressions of scholarship, libraries have not historically dedicated much of their acquisitions budgets to this area. Therefore, the comic book or graphic novel was largely relegated to someone’s personal collection and would more likely be found on the shelves of a comic book store than the shelves of a university library.

Fast-forward to the present day, where library collections more commonly provide access to comic books, either in regular …


The Magnetic Pull Of American Discovery: Second Thoughts About American Exceptionalism?, Richard L. Marcus Jan 2023

The Magnetic Pull Of American Discovery: Second Thoughts About American Exceptionalism?, Richard L. Marcus

Faculty Scholarship

No abstract provided.


Vaccination Mandates—An Old Public Health Tool Faces New Challenges, Dorit Rubenstein Reiss, Lawrence O. Gostin, Michelle M. Mello Jan 2023

Vaccination Mandates—An Old Public Health Tool Faces New Challenges, Dorit Rubenstein Reiss, Lawrence O. Gostin, Michelle M. Mello

Faculty Scholarship

No abstract provided.


Misinformation And Covid-19, Dorit Rubenstein Reiss Jan 2023

Misinformation And Covid-19, Dorit Rubenstein Reiss

Faculty Scholarship

The COVID-19 pandemic’s impact on our world cannot be overstated. One of its noticeable features was the prominence of misinformation generally, and anti-vaccine misinformation more specifically. This article provides a breakdown of the five major themes of antivaccine misinformation and the way they were used to create fear, uncertainty, and doubt about COVID- 19 vaccines. Long before the pandemic, anti-vaccine activists argued using a five-part playbook. They argued that (1) vaccine preventable diseases were not really dangerous, (2) vaccines were dangerous and ineffective, (3) there were alternative treatments that were better than (dangerous and ineffective) vaccines, (4) there was a …


The Dog That Didn’T Bark: Looking For Techno-Libertarian Ideology In A Decade Of Public Discourse About Big Tech Regulation, Jodi L. Short, Reuel E, Schiller, Susan Sibley, Noah Jones, Babak Hammatian, Lee Anna Bowman-Carpio Jan 2023

The Dog That Didn’T Bark: Looking For Techno-Libertarian Ideology In A Decade Of Public Discourse About Big Tech Regulation, Jodi L. Short, Reuel E, Schiller, Susan Sibley, Noah Jones, Babak Hammatian, Lee Anna Bowman-Carpio

Faculty Scholarship

The internet was built on the techno-libertarian ideology that “information wants to be free,” and that ideology has played a prominent role in academic and policy debates about regulating the internet and the big technology companies that dominate it.2 Techno-libertarian ideology has generated a constellation of claims about tech and regulation—from the suggestion that regulation will stifle innovation in the complex, dynamic tech sector, to the assertion that the large platform companies are literally not regulable. In this article, we explore how much traction such claims and ideologies have in the broader public discourse about big tech and regulation. We …


Regulatory Managerialism As Gaslighting Government, Jodi L. Short Jan 2023

Regulatory Managerialism As Gaslighting Government, Jodi L. Short

Faculty Scholarship

No abstract provided.


The Uncertain Future Of Restorative Justice: Anti-Woke Legislation, Retrenchment And Politics Of The Right, Thalia Gonzalez, Mara Schiff Jan 2023

The Uncertain Future Of Restorative Justice: Anti-Woke Legislation, Retrenchment And Politics Of The Right, Thalia Gonzalez, Mara Schiff

Faculty Scholarship

As diverse forms of anti-democratic and anti-inclusionary politics escalate in the United States, public education is increasingly a site for retrenchment and contestation with targeted efforts to silence and erase civil rights victories for equity and access. Addressing a critical, yet unattended issue at the intersection of education law and policy and civil rights, this Article joins with the growing discourse interrogating the “parental rights” movement and racially regressive legislation. Employing a case study analysis of social movement activism and education policy legislation from 2018–2023 in Florida, it aims to provoke critical praxis emanating from essential inquiry— what is the …


Rights Violations As Punishment, Kate Weisburd Jan 2023

Rights Violations As Punishment, Kate Weisburd

Faculty Scholarship

Is punishment generally exempt from the Constitution? That is, can the deprivation of basic constitutional rights—such as the rights to marry, bear children, worship, consult a lawyer, and protest—be imposed as direct punishment for a crime and in lieu of prison, so long as such intrusions are not “cruel and unusual” under the Eighth Amendment? On one hand, such state intrusion on fundamental rights would seem unconstitutional. On the other hand, such intrusions are often less harsh than the restriction of rights inherent in prison. If a judge can sentence someone to life in prison, how can a judge not …


Effects Of Landscape Configuration Metrics On American Barn Owl Nest Box Occupancy And Hunting, Samantha D. Chavez Jan 2023

Effects Of Landscape Configuration Metrics On American Barn Owl Nest Box Occupancy And Hunting, Samantha D. Chavez

Cal Poly Humboldt theses and projects

Harnessing ecosystem services, broadly defined as the benefits nature gives to people, is one approach to minimize the widespread negative impacts of agriculture on wildlife and biodiversity conservation. Conservation biological control is one such service that aims to use natural enemies to reduce crops losses from pests without the use of harmful pesticides, including rodenticides. In Napa Valley, California, human-made nest boxes are deployed on wine grape vineyards to attract barn owls (Tyto furcata) that depredate and remove thousands of rodent pests throughout the nesting season. However, the provisioning of this ecosystem service depends on whether a box …


Examining Educator Burnout And Classroom Outcomes As Correlates To Teaching Pyramid Implementation, April N. Frazer Jan 2023

Examining Educator Burnout And Classroom Outcomes As Correlates To Teaching Pyramid Implementation, April N. Frazer

Cal Poly Humboldt theses and projects

The Teaching Pyramid is a research-based socio-emotional framework created for implementation in early childhood education programs. It is designed to support children’s socio-emotional development and decrease persistent challenging behaviors. Challenging child behaviors have been linked to early educator stress. Job stressors in early childhood educators have been previously linked to educator burnout.

This study examined fidelity of implementation of the Teaching Pyramid framework as well as experience being trained and coached on the framework in 21 early childhood educators. It evaluated how these variables correlated with educator burnout, children’s socio-emotional development, and observed quality of care in nine Head Start …


A Test Of Subjective Versus Objective Language Proficiency: An Investigation Of Age Of Acquisition And Exposure In Multilinguals, Anastina B. Steiber Jan 2023

A Test Of Subjective Versus Objective Language Proficiency: An Investigation Of Age Of Acquisition And Exposure In Multilinguals, Anastina B. Steiber

Cal Poly Humboldt theses and projects

This research used the BEST dataset gathered in 2017 by de Bruin and colleagues, which contains information gathered from 650 multilingual participants (435 female, Mage = 25.02) from the Basque Country at the Basque Center on Cognition, Brain and Language (BCBL). Multilingual individuals may have different levels of proficiency in each language they speak, and there are various factors that can influence proficiency. Such factors include the age at which they begin learning a language and how much exposure they have to the language. Proficiency can be assessed both subjectively (personal perception of proficiency) and objectively (observed and/or measured …


Factors Contributing To Legacy Hardwood Mortality Following Prescribed Fire, Heather D. Rickard Jan 2023

Factors Contributing To Legacy Hardwood Mortality Following Prescribed Fire, Heather D. Rickard

Cal Poly Humboldt theses and projects

Interruption of Indigenous stewardship has resulted in hardwood decline along what is now known as the middle Klamath River in northern California related to adverse effects to Tribal food sovereignty and community wellbeing. The survivors of a “legacy” of Indigenous stewardship are highly valued by the Karuk and neighboring Tribes for a myriad of culturally beneficial ecological associations and sources of traditional staple foods. Prescribed fire, following a century of fire exclusion, has resulted in unanticipated mortality of legacy tanoak (Notholithocarpus densiflorus), California black oak (Quercus kelloggii), and madrone (Arbutus menziesii), warranting further investigation. …


Extremism In America: Explaining Political Extremism Using Uncertainty-Identity Theory, Natasha A. La Vogue Jan 2023

Extremism In America: Explaining Political Extremism Using Uncertainty-Identity Theory, Natasha A. La Vogue

Cal Poly Humboldt theses and projects

Navigating a post-pandemic society, climate-change, political conflict and international wars have become part of most people’s daily existence. These crises are sources of societal and personal uncertainty. An effective method of uncertainty reduction comes from people’s entrenched group memberships (e.g. nation, political party). Unfortunately, groups with extreme norms and ideologies provide rigid structures that aid in uncertainty reduction. From white nationalists to anti-fascists, the political arena is tumultuous to the point of explosion. These eruptions can be violent, even deadly, and are becoming too familiar and recognizable. Extremism poses both international and domestic threats. There is no nation or society …


Socio-Economic Comparative Analysis Of Front-Of-The-Meter And Behind-The-Meter Microgrids For Panamnik, Olivia C. Amann Mcshea Jan 2023

Socio-Economic Comparative Analysis Of Front-Of-The-Meter And Behind-The-Meter Microgrids For Panamnik, Olivia C. Amann Mcshea

Cal Poly Humboldt theses and projects

In Northern California, the Karuk Tribe is feeling the effects of climate change on inadequate energy infrastructures leading to unreliable power supply. Improving energy reliability in a way that also increases energy sovereignty is necessary. Renewable energy microgrids have emerged as a pathway forward.

Modeling ownership structures and cash flows for different microgrid configurations can support the Tribe’s implementation of a microgrid in Orleans, CA that maximizes community benefits. This thesis considers a front-of-the-meter (FTM) and behind-the-meter (BTM) configuration, both approximately 2 MW solar PV and 3 MW/12 MWh battery energy storage. Cash flows including capital costs, operations and maintenance …


California State University (Csu) Police Department Leadership Evaluation, Berkeley Kijsriopas Jan 2023

California State University (Csu) Police Department Leadership Evaluation, Berkeley Kijsriopas

Cal Poly Humboldt theses and projects

Leaders have the ability transform lives and societies and can motivate people for greatness or terrible things. Within a California State University police department, Chiefs of Police are important decision makers that can influence and shape the departments norms, values, goals, behaviors and attitudes. A leadership evaluation (N = 333), was used to explore the effects of leader prototypicality, officer self-uncertainty and social identity continuity through union leadership evaluations. The initial hypothesis that social identity continuity positively predicts group identification and is moderated by leader support was supported. However, the second hypothesis that the relationship between prototypical leaders and …


Community Ecology And Disease Dynamics In Pacific Oysters: Unraveling Microbiome-Pathogen Interactions In The Wild, Victoria E. Cifelli Jan 2023

Community Ecology And Disease Dynamics In Pacific Oysters: Unraveling Microbiome-Pathogen Interactions In The Wild, Victoria E. Cifelli

Cal Poly Humboldt theses and projects

In the context of multispecies microbial assemblages, disruptions can occur when there are alterations in host conditions, such as the onset of a disease. Notably, viruses have the potential to reshape a host's microbial community. However, the role of the host's habitat and environment, which could be pivotal in communities with shifting niche space and habitat filters, is often overlooked in host-microbe-pathogen interactions. Recognizing the importance of these factors, I employed a field-based approach to understand microbial community dynamics in the presence of disease. To address the influence of geographical location, I conducted an analysis involving healthy and infected oysters …


Leaving Kindergarten Well: First-Grade Readiness In Outdoor Waldorf Kindergartens, Garry H. Oak Jan 2023

Leaving Kindergarten Well: First-Grade Readiness In Outdoor Waldorf Kindergartens, Garry H. Oak

Leadership for Sustainability Education Comprehensive Papers

This article proposes an intervention to address the complex needs of children in outdoor Waldorf kindergartens. The intervention suggests integrating cultural responsiveness practices, remedial education, and outdoor teacher training competency into existing teacher training programs. By adopting this comprehensive approach, new teachers can acquire the necessary tools to meet the diverse needs of their students and adapt to the challenges of modern education. Ongoing professional development programs are also recommended to enable teachers to continuously enhance their skills throughout their careers. This multi-pronged solution aims to establish a more equitable and effective educational system that considers various dimensions of children's …


Trauma‐Informed Care Implementation Assessment Instrument, Karen Cellarius, Aliza Tuttle, Christine A. Da Rosa Jan 2023

Trauma‐Informed Care Implementation Assessment Instrument, Karen Cellarius, Aliza Tuttle, Christine A. Da Rosa

Regional Research Institute for Human Services

Trauma Informed Oregon’s Trauma-Informed Care (TIC) Implementation Tool provides a framework for incorporating trauma-informed policies, practices and care into any organization’s structure. It was originally created in 2022 by Trauma Informed Oregon (TIO) and the Human Services Implementation Lab (iLab) at Portland State University’s Regional Research Institute. Implementation of Trauma-Informed Care is an ongoing process and is not expected to happen all at once. Systematically assessing TIC implementation accomplishes two things. First, it documents the extent that the organization is trauma-informed and clearly identifies systemic strengths, weaknesses and gaps. Second, it helps the organization decide on overall goals, and identify …


Implications Of Physical Fault Injections On Single Chip Motes, Sara Faour, Mališa Vučinić, Filip Maksimovic, David Burnett, Paul Muhlethaler, Thomas Watteyne, Kristofer Pister Jan 2023

Implications Of Physical Fault Injections On Single Chip Motes, Sara Faour, Mališa Vučinić, Filip Maksimovic, David Burnett, Paul Muhlethaler, Thomas Watteyne, Kristofer Pister

Electrical and Computer Engineering Faculty Publications and Presentations

Single-chip motes are wireless sensor nodes that integrate computation, communication, power and sensing on a single chip. We consider the security threats these novel devices are subject to when employed in safety-critical applications. Fault injection attacks are a prominent form of physical attacks that pose a threat to the normal and secure functioning of targeted devices, potentially compromising their intended behavior. These attacks have been studied mainly on commercial off-the-shelf devices which rely on external components such as crystal oscillators and passives. Such external components are absent from single-chip motes, resulting in a uniquely different attack surface compared to commercial …


Milder Loss Of Insulin-Containing Islets In Individuals With Type 1 Diabetes And Type 2 Diabetes-Associated Tcf7l2 Genetic Variants, Maria J Redondo, Sarah J Richardson, Daniel Perry, Charles G Minard, Alice L J Carr, Todd Brusko, Irina Kusmartseva, Alberto Pugliese, Mark A Atkinson Jan 2023

Milder Loss Of Insulin-Containing Islets In Individuals With Type 1 Diabetes And Type 2 Diabetes-Associated Tcf7l2 Genetic Variants, Maria J Redondo, Sarah J Richardson, Daniel Perry, Charles G Minard, Alice L J Carr, Todd Brusko, Irina Kusmartseva, Alberto Pugliese, Mark A Atkinson

Faculty, Staff and Students Publications

AIMS/HYPOTHESIS: TCF7L2 variants are the strongest genetic risk factor for type 2 diabetes. In individuals with type 1 diabetes, these variants are associated with a higher C-peptide AUC, a lower glucose AUC during an OGTT, single autoantibody positivity near diagnosis, particularly in individuals older than 12 years of age, and a lower frequency of type 1 diabetes-associated HLA genotypes. Based on initial observations from clinical cohorts, we tested the hypothesis that type 2 diabetes-predisposing TCF7L2 genetic variants are associated with a higher percentage of residual insulin-containing cells (ICI%) in pancreases of donors with type 1 diabetes, by examining genomic data …


Wastewater Pandemic Preparedness: Toward An End-To-End Pathogen Monitoring Program, Justin R Clark, Austen Terwilliger, Vasanthi Avadhanula, Michael Tisza, Juwan Cormier, Sara Javornik-Cregeen, Matthew Clayton Ross, Kristi Louise Hoffman, Catherine Troisi, Blake Hanson, Joseph Petrosino, John Balliew, Pedro A Piedra, Janelle Rios, Jennifer Deegan, Cici Bauer, Fuqing Wu, Kristina D Mena, Eric Boerwinkle, Anthony W Maresso Jan 2023

Wastewater Pandemic Preparedness: Toward An End-To-End Pathogen Monitoring Program, Justin R Clark, Austen Terwilliger, Vasanthi Avadhanula, Michael Tisza, Juwan Cormier, Sara Javornik-Cregeen, Matthew Clayton Ross, Kristi Louise Hoffman, Catherine Troisi, Blake Hanson, Joseph Petrosino, John Balliew, Pedro A Piedra, Janelle Rios, Jennifer Deegan, Cici Bauer, Fuqing Wu, Kristina D Mena, Eric Boerwinkle, Anthony W Maresso

Faculty, Staff and Student Publications

Molecular analysis of public wastewater has great potential as a harbinger for community health and health threats. Long-used to monitor the presence of enteric viruses, in particular polio, recent successes of wastewater as a reliable lead indicator for trends in SARS-CoV-2 levels and hospital admissions has generated optimism and emerging evidence that similar science can be applied to other pathogens of pandemic potential (PPPs), especially respiratory viruses and their variants of concern (VOC). However, there are substantial challenges associated with implementation of this ideal, namely that multiple and distinct fields of inquiry must be bridged and coordinated. These include engineering, …


Implementation And Outcomes Of A Comprehensive Emergency Care Curriculum At A Low-Resource Referral Hospital In Liberia: A Novel Approach To Application Of The Who Basic Emergency Care Toolkit, Lane Epps, Anu Ramachandran, Sojung Yi, Alexander Mayah, Taylor Burkholder, Michael Jaung, Ahson Haider, Paul Wesseh, John Shakpeh, Corey Bills, Kayla Enriquez Jan 2023

Implementation And Outcomes Of A Comprehensive Emergency Care Curriculum At A Low-Resource Referral Hospital In Liberia: A Novel Approach To Application Of The Who Basic Emergency Care Toolkit, Lane Epps, Anu Ramachandran, Sojung Yi, Alexander Mayah, Taylor Burkholder, Michael Jaung, Ahson Haider, Paul Wesseh, John Shakpeh, Corey Bills, Kayla Enriquez

Faculty, Staff and Students Publications

BACKGROUND: Emergency care is vital in low- and middle-income countries (LMICs) but many frontline healthcare workers in low-resource settings have no formal training in emergency care. To address this gap, the World Health Organization (WHO) developed Basic Emergency Care (BEC): Approach to the acutely ill and injured, a multi-day, open-source course for healthcare workers in low-resource settings. Building on the BEC foundation, this study uses an implementation science (IS) lens to develop, implement, and evaluate a comprehensive emergency care curriculum in a single emergency facility in Liberia.

METHODS: A six-month emergency care curriculum consisting of BEC content, standardized WHO clinical …


Adeno-Associated Virus 8 Delivers An Immunomodulatory Peptide To Mouse Liver More Efficiently Than To Rat Liver, Yuqing Wang, Ayrea Hurley, Marco De Giorgi, Mark R Tanner, Rong-Chi Hu, Michael W Pennington, William R Lagor, Christine Beeton Jan 2023

Adeno-Associated Virus 8 Delivers An Immunomodulatory Peptide To Mouse Liver More Efficiently Than To Rat Liver, Yuqing Wang, Ayrea Hurley, Marco De Giorgi, Mark R Tanner, Rong-Chi Hu, Michael W Pennington, William R Lagor, Christine Beeton

Faculty, Staff and Students Publications

Targeting the Kv1.3 potassium channel has proven effective in reducing obesity and the severity of animal models of autoimmune disease. Stichodactyla toxin (ShK), isolated from the sea anemone Stichodactyla helianthus, is a potent blocker of Kv1.3. Several of its analogs are some of the most potent and selective blockers of this channel. However, like most biologics, ShK and its analogs require injections for their delivery, and repeated injections reduce patient compliance during the treatment of chronic diseases. We hypothesized that inducing the expression of an ShK analog by hepatocytes would remove the requirement for frequent injections and lead to a …


Association Of Hearing Loss And Tinnitus Symptoms With Health-Related Quality Of Life Among Long-Term Oropharyngeal Cancer Survivors, Puja Aggarwal, Marc-Elie Nader, Paul W Gidley, Raj Pratihar, Shirin Jivani, Adam S Garden, Frank E Mott, Ryan P Goepfert, Christopher Wallace Ogboe, Camille Charles, Clifton D Fuller, Stephen Y Lai, G Brandon Gunn, Erich M Sturgis, Ehab Y Hanna, Katherine A Hutcheson, Sanjay Shete Jan 2023

Association Of Hearing Loss And Tinnitus Symptoms With Health-Related Quality Of Life Among Long-Term Oropharyngeal Cancer Survivors, Puja Aggarwal, Marc-Elie Nader, Paul W Gidley, Raj Pratihar, Shirin Jivani, Adam S Garden, Frank E Mott, Ryan P Goepfert, Christopher Wallace Ogboe, Camille Charles, Clifton D Fuller, Stephen Y Lai, G Brandon Gunn, Erich M Sturgis, Ehab Y Hanna, Katherine A Hutcheson, Sanjay Shete

Faculty, Staff and Student Publications

BACKGROUND: This study investigated the association of hearing loss and tinnitus with overall health-related quality of life (HRQoL) among long-term oropharyngeal cancer (OPC) survivors.

METHODS: This study included OPC survivors treated between 2000 and 2013 and surveyed from September 2015 to July 2016. Hearing loss and tinnitus were measured by asking survivors to rate their "difficulty with hearing loss and/or ringing in the ears" from 0 (not present) to 10 (as bad as you can imagine). Hearing loss and tinnitus scores were categorized as follows: 0 for none, 1-4 for mild, and 5-10 for moderate to severe. The primary outcome …


Gene-Educational Attainment Interactions In A Multi-Population Genome-Wide Meta-Analysis Identify Novel Lipid Loci, Lisa De Las Fuentes, Karen L Schwander, Michael R Brown, Amy R Bentley, Thomas W Winkler, Yun Ju Sung, Patricia B Munroe, Clint L Miller, Hugo Aschard, Stella Aslibekyan, Traci M Bartz, Lawrence F Bielak, Jin Fang Chai, Ching-Yu Cheng, Rajkumar Dorajoo, Mary F Feitosa, Xiuqing Guo, Fernando P Hartwig, Andrea Horimoto, Ivana Kolčić, Elise Lim, Yongmei Liu, Alisa K Manning, Jonathan Marten, Solomon K Musani, Raymond Noordam, Sandosh Padmanabhan, Tuomo Rankinen, Melissa A Richard, Paul M Ridker, Albert V Smith, Dina Vojinovic, Alan B Zonderman, Maris Alver, Mathilde Boissel, Kaare Christensen, Barry I Freedman, Chuan Gao, Franco Giulianini, Sarah E Harris, Meian He, Fang-Chi Hsu, Brigitte Kühnel, Federica Laguzzi, Xiaoyin Li, Leo-Pekka Lyytikäinen, Ilja M Nolte, Alaitz Poveda, Rainer Rauramaa, Muhammad Riaz, Antonietta Robino, Tamar Sofer, Fumihiko Takeuchi, Bamidele O Tayo, Peter J Van Der Most, Niek Verweij, Erin B Ware, Stefan Weiss, Wanqing Wen, Lisa R Yanek, Yiqiang Zhan, Najaf Amin, Dan E Arking, Christie Ballantyne, Eric Boerwinkle, Jennifer A Brody, Ulrich Broeckel, Archie Campbell, Mickaël Canouil, Xiaoran Chai, Yii-Der Ida Chen, Xu Chen, Kumaraswamy Naidu Chitrala, Maria Pina Concas, Ulf De Faire, Renée De Mutsert, H Janaka De Silva, Paul S De Vries, Ahn Do, Jessica D Faul, Virginia Fisher, James S Floyd, Terrence Forrester, Yechiel Friedlander, Giorgia Girotto, C Charles Gu, Göran Hallmans, Sami Heikkinen, Chew-Kiat Heng, Georg Homuth, Steven Hunt, M Arfan Ikram, David R Jacobs, Maryam Kavousi, Chiea Chuen Khor, Tuomas O Kilpeläinen, Woon-Puay Koh, Pirjo Komulainen, Carl D Langefeld, Jingjing Liang, Kiang Liu, Jianjun Liu, Kurt Lohman, Reedik Mägi, Ani W Manichaikul, Colin A Mckenzie, Thomas Meitinger, Yuri Milaneschi, Matthias Nauck, Christopher P Nelson, Jeffrey R O'Connell, Nicholette D Palmer, Alexandre C Pereira, Thomas Perls, Annette Peters, Ozren Polašek, Olli T Raitakari, Kenneth Rice, Treva K Rice, Stephen S Rich, Charumathi Sabanayagam, Pamela J Schreiner, Xiao-Ou Shu, Stephen Sidney, Mario Sims, Jennifer A Smith, John M Starr, Konstantin Strauch, E Shyong Tai, Kent D Taylor, Michael Y Tsai, André G Uitterlinden, Diana Van Heemst, Melanie Waldenberger, Ya-Xing Wang, Wen-Bin Wei, Gregory Wilson, Deng Xuan, Jie Yao, Caizheng Yu, Jian-Min Yuan, Wei Zhao, Diane M Becker, Amélie Bonnefond, Donald W Bowden, Richard S Cooper, Ian J Deary, Jasmin Divers, Tõnu Esko, Paul W Franks, Philippe Froguel, Christian Gieger, Jost B Jonas, Norihiro Kato, Timo A Lakka, Karin Leander, Terho Lehtimäki, Patrik K E Magnusson, Kari E North, Ioanna Ntalla, Brenda Penninx, Nilesh J Samani, Harold Snieder, Beatrice Spedicati, Pim Van Der Harst, Henry Völzke, Lynne E Wagenknecht, David R Weir, Mary K Wojczynski, Tangchun Wu, Wei Zheng, Xiaofeng Zhu, Claude Bouchard, Daniel I Chasman, Michele K Evans, Ervin R Fox, Vilmundur Gudnason, Caroline Hayward, Bernardo L Horta, Sharon L R Kardia, Jose Eduardo Krieger, Dennis O Mook-Kanamori, Patricia A Peyser, Michael M Province, Bruce M Psaty, Igor Rudan, Xueling Sim, Blair H Smith, Rob M Van Dam, Cornelia M Van Duijn, Tien Yin Wong, Donna K Arnett, Dabeeru C Rao, James Gauderman, Ching-Ti Liu, Alanna C Morrison, Jerome I Rotter, Myriam Fornage Jan 2023

Gene-Educational Attainment Interactions In A Multi-Population Genome-Wide Meta-Analysis Identify Novel Lipid Loci, Lisa De Las Fuentes, Karen L Schwander, Michael R Brown, Amy R Bentley, Thomas W Winkler, Yun Ju Sung, Patricia B Munroe, Clint L Miller, Hugo Aschard, Stella Aslibekyan, Traci M Bartz, Lawrence F Bielak, Jin Fang Chai, Ching-Yu Cheng, Rajkumar Dorajoo, Mary F Feitosa, Xiuqing Guo, Fernando P Hartwig, Andrea Horimoto, Ivana Kolčić, Elise Lim, Yongmei Liu, Alisa K Manning, Jonathan Marten, Solomon K Musani, Raymond Noordam, Sandosh Padmanabhan, Tuomo Rankinen, Melissa A Richard, Paul M Ridker, Albert V Smith, Dina Vojinovic, Alan B Zonderman, Maris Alver, Mathilde Boissel, Kaare Christensen, Barry I Freedman, Chuan Gao, Franco Giulianini, Sarah E Harris, Meian He, Fang-Chi Hsu, Brigitte Kühnel, Federica Laguzzi, Xiaoyin Li, Leo-Pekka Lyytikäinen, Ilja M Nolte, Alaitz Poveda, Rainer Rauramaa, Muhammad Riaz, Antonietta Robino, Tamar Sofer, Fumihiko Takeuchi, Bamidele O Tayo, Peter J Van Der Most, Niek Verweij, Erin B Ware, Stefan Weiss, Wanqing Wen, Lisa R Yanek, Yiqiang Zhan, Najaf Amin, Dan E Arking, Christie Ballantyne, Eric Boerwinkle, Jennifer A Brody, Ulrich Broeckel, Archie Campbell, Mickaël Canouil, Xiaoran Chai, Yii-Der Ida Chen, Xu Chen, Kumaraswamy Naidu Chitrala, Maria Pina Concas, Ulf De Faire, Renée De Mutsert, H Janaka De Silva, Paul S De Vries, Ahn Do, Jessica D Faul, Virginia Fisher, James S Floyd, Terrence Forrester, Yechiel Friedlander, Giorgia Girotto, C Charles Gu, Göran Hallmans, Sami Heikkinen, Chew-Kiat Heng, Georg Homuth, Steven Hunt, M Arfan Ikram, David R Jacobs, Maryam Kavousi, Chiea Chuen Khor, Tuomas O Kilpeläinen, Woon-Puay Koh, Pirjo Komulainen, Carl D Langefeld, Jingjing Liang, Kiang Liu, Jianjun Liu, Kurt Lohman, Reedik Mägi, Ani W Manichaikul, Colin A Mckenzie, Thomas Meitinger, Yuri Milaneschi, Matthias Nauck, Christopher P Nelson, Jeffrey R O'Connell, Nicholette D Palmer, Alexandre C Pereira, Thomas Perls, Annette Peters, Ozren Polašek, Olli T Raitakari, Kenneth Rice, Treva K Rice, Stephen S Rich, Charumathi Sabanayagam, Pamela J Schreiner, Xiao-Ou Shu, Stephen Sidney, Mario Sims, Jennifer A Smith, John M Starr, Konstantin Strauch, E Shyong Tai, Kent D Taylor, Michael Y Tsai, André G Uitterlinden, Diana Van Heemst, Melanie Waldenberger, Ya-Xing Wang, Wen-Bin Wei, Gregory Wilson, Deng Xuan, Jie Yao, Caizheng Yu, Jian-Min Yuan, Wei Zhao, Diane M Becker, Amélie Bonnefond, Donald W Bowden, Richard S Cooper, Ian J Deary, Jasmin Divers, Tõnu Esko, Paul W Franks, Philippe Froguel, Christian Gieger, Jost B Jonas, Norihiro Kato, Timo A Lakka, Karin Leander, Terho Lehtimäki, Patrik K E Magnusson, Kari E North, Ioanna Ntalla, Brenda Penninx, Nilesh J Samani, Harold Snieder, Beatrice Spedicati, Pim Van Der Harst, Henry Völzke, Lynne E Wagenknecht, David R Weir, Mary K Wojczynski, Tangchun Wu, Wei Zheng, Xiaofeng Zhu, Claude Bouchard, Daniel I Chasman, Michele K Evans, Ervin R Fox, Vilmundur Gudnason, Caroline Hayward, Bernardo L Horta, Sharon L R Kardia, Jose Eduardo Krieger, Dennis O Mook-Kanamori, Patricia A Peyser, Michael M Province, Bruce M Psaty, Igor Rudan, Xueling Sim, Blair H Smith, Rob M Van Dam, Cornelia M Van Duijn, Tien Yin Wong, Donna K Arnett, Dabeeru C Rao, James Gauderman, Ching-Ti Liu, Alanna C Morrison, Jerome I Rotter, Myriam Fornage

Faculty, Staff and Student Publications

Introduction: Educational attainment, widely used in epidemiologic studies as a surrogate for socioeconomic status, is a predictor of cardiovascular health outcomes.

Methods: A two-stage genome-wide meta-analysis of low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), and triglyceride (TG) levels was performed while accounting for gene-educational attainment interactions in up to 226,315 individuals from five population groups. We considered two educational attainment variables: “Some College” (yes/no, for any education beyond high school) and “Graduated College” (yes/no, for completing a 4-year college degree). Genome-wide significant (p < 5 × 10−8) and suggestive (p < 1 × 10−6) variants were identified in Stage 1 (in up to 108,784 individuals) through genome-wide analysis, and those variants were followed up in Stage 2 studies (in up to 117,531 individuals).

Results: In combined analysis of Stages 1 and 2, we identified 18 novel lipid loci (nine …


Quantitative Measurement Of Protac Intracellular Accumulation, Xin Yu, Jin Wang Jan 2023

Quantitative Measurement Of Protac Intracellular Accumulation, Xin Yu, Jin Wang

Faculty, Staff and Students Publications

In recent years, Proteolysis Targeting Chimera (PROTAC) technology has emerged as one of the most promising approaches to remove disease-associated proteins by utilizing cells' own destruction machinery. To achieve successful degradation of a protein of interest (POI), the heterobifunctional PROTAC molecules must penetrate into the cells first, followed by target engagement and formation of the POI-PROTAC-E3 ligase complex. Based on this understanding, the assessment of cell permeability and in cell target engagement are of great importance to evaluate the efficacy of PROTAC candidates. PROTAC molecules can be classified as non-covalent and covalent, and covalent PROTACs can be further divided into …


Mass Spectrometry Imaging As An Emerging Tool For Studying Metabolism In Human Brain Organoids, Gerarda Cappuccio, Saleh M Khalil, Sivan Osenberg, Feng Li, Mirjana Maletic-Savatic Jan 2023

Mass Spectrometry Imaging As An Emerging Tool For Studying Metabolism In Human Brain Organoids, Gerarda Cappuccio, Saleh M Khalil, Sivan Osenberg, Feng Li, Mirjana Maletic-Savatic

Faculty, Staff and Students Publications

Human brain organoids are emerging models to study human brain development and pathology as they recapitulate the development and characteristics of major neural cell types, and enable manipulation through an in vitro system. Over the past decade, with the advent of spatial technologies, mass spectrometry imaging (MSI) has become a prominent tool for metabolic microscopy, providing label-free, non-targeted molecular and spatial distribution information of the metabolites within tissue, including lipids. This technology has never been used for studies of brain organoids and here, we set out to develop a standardized protocol for preparation and mass spectrometry imaging of human brain …


Mortality Difference From Klebsiella Aerogenes Vs Enterobacter Cloacae Bloodstream Infections, Andrew Chou, Richard Sucgang, Richard J Hamill, Lynn Zechiedrich, Barbara W Trautner Jan 2023

Mortality Difference From Klebsiella Aerogenes Vs Enterobacter Cloacae Bloodstream Infections, Andrew Chou, Richard Sucgang, Richard J Hamill, Lynn Zechiedrich, Barbara W Trautner

Faculty, Staff and Students Publications

Members of the order Enterobacterales, including Escherichia coli , Klebsiella species and Enterobacter species, are important pathogens in healthcare-associated infections. Higher mortality has been reported from infections due to Klebsiella pneumoniae than from E. coli , but prior studies comparing Enterobacter aerogenes (recently renamed Klebsiella aerogenes ) bacteraemia and Enterobacter cloacae complex bacteraemia have yielded conflicting results regarding whether clinical outcomes differ. We found bacteraemia with K. aerogenes was independently associated with greater risk of 30-day mortality than bacteraemia with Enterobacter cloacae complex.


Resident Education And Virtual Medicine: A Faculty Development Session To Enhance Trainee Skills In The Realm Of Telemedicine, Anna E Rueda, Ana C Monterrey, Margaret Wood, Linessa Zuniga, Betty Del Rio Rodriguez Jan 2023

Resident Education And Virtual Medicine: A Faculty Development Session To Enhance Trainee Skills In The Realm Of Telemedicine, Anna E Rueda, Ana C Monterrey, Margaret Wood, Linessa Zuniga, Betty Del Rio Rodriguez

Faculty, Staff and Students Publications

INTRODUCTION: COVID-19 accelerated the use of telemedicine. Subsequently, clinical sites began conducting virtual visits. Academic institutions implemented telemedicine for patient care and simultaneously had to teach residents the logistics and best practices. To meet this need, we developed a training session for faculty focused on telemedicine best practices and teaching telemedicine in the pediatric realm.

METHODS: We designed this training session based on institutional and society guidelines and faculty experience with telemedicine. Objectives included telemedicine documentation, triage, counseling, and ethical issues in telemedicine. We conducted all sessions in a 60-minute or 90-minute format over a virtual platform for small and …