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Fakestack: Hierarchical Tri-Bert-Cnn-Lstm Stacked Model For Effective Fake News Detection
Fakestack: Hierarchical Tri-Bert-Cnn-Lstm Stacked Model For Effective Fake News Detection
Faculty, Staff and Student Publications
False news articles pose a serious challenge in today's information landscape, impacting public opinion and decision-making. Efforts to counter this issue have led to research in deep learning and machine learning methods. However, a gap exists in effectively using contextual cues and skip connections within models, limiting the development of comprehensive detection systems that harness contextual information and vital data propagation. Thus, we propose a model of deep learning, FakeStack, in order to identify bogus news accurately. The model combines the power of pre-trained Bidirectional Encoder Representation of Transformers (BERT) embeddings with a deep Convolutional Neural Network (CNN) having skip …
Assessing Pandemic Preparedness, Response, And Lessons Learned From The Covid-19 Pandemic In Four South American Countries: Agenda For The Future, Rachid Laajaj, Ana María Vesga Gaviria, Ana María Ortiz Hoyos, Esteban Orlando Vanegas Duarte, Alejandra Velásquez Morales, Nubia Velasco, Silvia Restrepo Restrepo
Assessing Pandemic Preparedness, Response, And Lessons Learned From The Covid-19 Pandemic In Four South American Countries: Agenda For The Future, Rachid Laajaj, Ana María Vesga Gaviria, Ana María Ortiz Hoyos, Esteban Orlando Vanegas Duarte, Alejandra Velásquez Morales, Nubia Velasco, Silvia Restrepo Restrepo
Faculty, Staff and Student Publications
INTRODUCTION: The COVID-19 pandemic emerged in a context that lacked adequate prevention, preparedness, and response (PPR) activities, and global, regional, and national leadership. South American countries were among world's hardest hit by the pandemic, accounting for 10.1% of total cases and 20.1% of global deaths.
METHODS: This study explores how pandemic PPR were affected by political, socioeconomic, and health system contexts as well as how PPR may have shaped pandemic outcomes in Argentina, Brazil, Colombia, and Peru. We then identify lessons learned and advance an agenda for improving PPR capacity at regional and national levels. We do this through a …
Caregiving To Older Adults With A Physical Limitation: Evidence From The Mexican Health And Aging Study
Faculty, Staff and Student Publications
BACKGROUND AND OBJECTIVES: Many older adults face physical limitations to performing activities of daily life (ADLs) and instrumental activities of daily life (IADLs) and seek help performing them. In Mexico, family caregivers, especially spouses and adult children, traditionally take care of older adults. However, a detailed characterization of the care received has not been thoroughly provided. We sought to identify socioeconomic, demographic, and health-related differences in receiving help among older adults reporting physical limitations.
RESEARCH DESIGN AND METHODS: Using the 2012 wave of the Mexican Health and Aging Study, we provided information on adults aged 60 and older who reported …
Lessons Learned From Interdisciplinary Efforts To Combat Covid-19 Misinformation: Development Of Agile Integrative Methods From Behavioral Science, Data Science, And Implementation Science, Jinni Tang, Trevor Cohen, Belinda Reininger, Lara S Savas, Maria E Fernandez
Lessons Learned From Interdisciplinary Efforts To Combat Covid-19 Misinformation: Development Of Agile Integrative Methods From Behavioral Science, Data Science, And Implementation Science, Jinni Tang, Trevor Cohen, Belinda Reininger, Lara S Savas, Maria E Fernandez
Faculty, Staff and Student Publications
BACKGROUND: Despite increasing awareness about and advances in addressing social media misinformation, the free flow of false COVID-19 information has continued, affecting individuals' preventive behaviors, including masking, testing, and vaccine uptake.
OBJECTIVE: In this paper, we describe our multidisciplinary efforts with a specific focus on methods to (1) gather community needs, (2) develop interventions, and (3) conduct large-scale agile and rapid community assessments to examine and combat COVID-19 misinformation.
METHODS: We used the Intervention Mapping framework to perform community needs assessment and develop theory-informed interventions. To supplement these rapid and responsive efforts through large-scale online social listening, we developed a …
Observed And Perceived Benefits Of Providing Physical Activity Opportunities In Elementary Schools: A Qualitative Study, Paula Cuccaro
Observed And Perceived Benefits Of Providing Physical Activity Opportunities In Elementary Schools: A Qualitative Study, Paula Cuccaro
Faculty, Staff and Student Publications
INTRODUCTION: Schools play an important role in promoting physical activity for youth. However, school-based physical activity opportunities often compete with other academic priorities, limiting their implementation. The purpose of this study was to qualitatively explore elementary school teacher and staff perspectives on providing physical activity opportunities and how they impact students and learning.
METHODS: We partnered with a school district in Texas to conduct semi-structured individual interviews. We used a purposeful sampling approach to recruit elementary teachers and staff knowledgeable about the physical activity opportunities provided at their school. Interviews included questions about participant opinions of providing physical activity opportunities …
Obtaining The Transfer Function Of A Camera Mount Using Ansys And Matlab, Ikechukwu Stanley Nwade
Obtaining The Transfer Function Of A Camera Mount Using Ansys And Matlab, Ikechukwu Stanley Nwade
Theses and Dissertations
In this thesis, the transfer function of a camera mount is obtained using ANSYS and MATLAB. In a heads-up display (HUD) application, achieving precise image registration requires careful consideration of the camera's position relative to the vehicle. Vibrations can alter the camera's position, with tilt being the most impactful due to its increased displacement effect as objects are further away. This research tackles vibration by predicting the position of the camera using transfer function. To determine the transfer function for complex structures, such as camera mounts, this study aims to first establish a transfer function for a simpler model, like …
Maternal Perceptions Of Vaccinating Boys Against Human Papillomavirus (Hpv) In Seoul, South Korea: A Descriptive Exploratory Qualitative Study, Paula Cuccaro
Faculty, Staff and Student Publications
Human Papillomavirus (HPV) vaccination is of paramount importance to reduce HPV-associated cancers in both genders. In South Korea, the prophylactic vaccine is recognized as prevention of cervical cancer with little attention given to male HPV vaccination. The purpose of this study was to explore perceptions of male HPV vaccination and underlying factors for vaccine hesitancy among mothers of unvaccinated boys in Seoul, Korea using a qualitative method. We used a purposive sampling strategy to recruit mothers of unvaccinated middle school-aged boys living in one of the 25 districts in Seoul, supplemented by a snowball sampling approach. We conducted one-on-one telephone …
Estimation Of Idle Time Using Machine Learning Models For Vehicle-To-Grid (V2g) Integration And Services, Prashanth Rajagopalan
Estimation Of Idle Time Using Machine Learning Models For Vehicle-To-Grid (V2g) Integration And Services, Prashanth Rajagopalan
Theses and Dissertations
As the Electric Vehicles (EVs) market continues to expand, ensuring the access to charging stations remains a significant concern. This work focuses on addressing multiple challenges related to EV charging behavior and Vehicle-to-Grid (V2G) services. Firstly, it focuses on accurate minute-ahead (20 minute \& 30 minute intervals) load forecasts for an EV charging station by using four years of historical data, from 2018-2021. This data is recorded from a university campus garage charging station. Machine Learning (ML) models such as Seasonal Auto-Regressive Integrated Moving Average (SARIMA), Random Forest (RF), and Neural Networks (NN) are employed for load forecasts in terms …
Anomaly Detection And Trajectory Prediction Models For Ads-B Datasets, Akshay Ram Ramchandra
Anomaly Detection And Trajectory Prediction Models For Ads-B Datasets, Akshay Ram Ramchandra
Theses and Dissertations
Global Positioning Systems (GPS) are critical for accurate navigation in aviation networks.GPS information could be subjected to several interferences due to challenging terrain, rural areas, high-rise buildings, and intentional or unintentional jamming, spoofing, or unknown causes. Recently, the frequency of GPS/Automatic Dependant Surveillance-Broadcast (ADS-B)-related interferences in commercial airlines has increased. This thesis focuses on enhancing civil aviation safety using machine learning (ML) algorithms, particularly focusing on vulnerabilities in the ADS-B and its role in improving the National Air Space (NAS) surveillance and safety. Through scholarly article surveys, foundational issues in the ADS-B are identified. A study centered around a GPS …
Gay Or Nay? Gaydar Snap Judgement Accuracy Rates Among Queer And Straight Cis-Men, Alyssa Noelle Rowland
Gay Or Nay? Gaydar Snap Judgement Accuracy Rates Among Queer And Straight Cis-Men, Alyssa Noelle Rowland
Theses and Dissertations
The validity of gaydar as a psychological construct has been evaluated in the LGBQIA2S+ literature with general agreement that an unclearly specified subset of the population has a better than chance probability of detecting the sexuality of others. The real-world implications of such a skill could be far-reaching. Gaydar could assist people identify and attract potential mates or life partners. It could also provide protection against the risks posed by making advances on an individual (e.g., a heterosexual man) who could react violently. The current study examined factors that impacted cis-male gaydar hit rates for queer and heterosexual targets in …
Performance Analysis Of Data-Driven Algorithms In Detecting Intrusions On Smart Grid, Tala Talaei Khoei
Performance Analysis Of Data-Driven Algorithms In Detecting Intrusions On Smart Grid, Tala Talaei Khoei
Theses and Dissertations
The traditional power grid is no longer a practical solution for power delivery due to several shortcomings, including chronic blackouts, energy storage issues, high cost of assets, and high carbon emissions. Therefore, there is a serious need for better, cheaper, and cleaner power grid technology that addresses the limitations of traditional power grids. A smart grid is a holistic solution to these issues that consists of a variety of operations and energy measures. This technology can deliver energy to end-users through a two-way flow of communication. It is expected to generate reliable, efficient, and clean power by integrating multiple technologies. …
Association Of The Gut Microbiome With Kidney Function And Damage In The Hispanic Community Health Study/Study Of Latinos (Hchs/Sol), Jianwen Cai, Marc D Gellman, Bing Yu, Eric Boerwinkle, Rob Knight, Robert D Burk, Robert C Kaplan
Association Of The Gut Microbiome With Kidney Function And Damage In The Hispanic Community Health Study/Study Of Latinos (Hchs/Sol), Jianwen Cai, Marc D Gellman, Bing Yu, Eric Boerwinkle, Rob Knight, Robert D Burk, Robert C Kaplan
Faculty, Staff and Student Publications
BACKGROUND: The gut microbiome is altered in chronic kidney disease (CKD), potentially contributing to CKD progression and co-morbidities, but population-based studies of the gut microbiome across a wide range of kidney function and damage are lacking.
METHODS: In the Hispanic Community Health Study/Study of Latinos, gut microbiome was assessed by shotgun sequencing of stool (
RESULTS: Higher eGFR was associated with overall gut microbiome composition, greater abundance of species from Prevotella, Faecalibacterium, Roseburia, and Eubacterium, and microbial functions related to synthesis of long-chain fatty acids and carbamoyl-phosphate. Higher UAC ratio and CKD were related to lower gut microbiome diversity and …
Toward A More Comprehensive Understanding Of Organizational Influences On Implementation: The Organization Theory For Implementation Science Framework, Jure Baloh, Manal Masud, Terry T-K Huang, Matthew Lee, Mary Wangen, Per Nilsen, Miriam Bender, Mimi Choy-Brown, Grace Ryan, Aliza Randazzo, Linda K Ko
Toward A More Comprehensive Understanding Of Organizational Influences On Implementation: The Organization Theory For Implementation Science Framework, Jure Baloh, Manal Masud, Terry T-K Huang, Matthew Lee, Mary Wangen, Per Nilsen, Miriam Bender, Mimi Choy-Brown, Grace Ryan, Aliza Randazzo, Linda K Ko
Faculty, Staff and Student Publications
Introduction: Implementation is influenced by factors beyond individual clinical settings. Nevertheless, implementation research often focuses on factors related to individual providers and practices, potentially due to limitations of available frameworks. Extant frameworks do not adequately capture the myriad organizational influences on implementation. Organization theories capture diverse organizational influences but remain underused in implementation science. To advance their use among implementation scientists, we distilled 70 constructs from nine organization theories identified in our previous work into theoretical domains in the Organization Theory for Implementation Science (OTIS) framework.
Methods: The process of distilling organization theory constructs into domains involved concept mapping and …
Hpv-Related Oropharyngeal Cancer Early Detection In Gay And Bisexual Men Is An “Orphan” Practice: A Qualitative Analysis Among Healthcare Providers
Faculty, Staff and Student Publications
Introduction: Among US men, oropharyngeal cancer (cancer of the back of the mouth and throat) is the 8th most common cancer. If detected early, human papillomavirus (HPV)-16-associated oropharyngeal cancer has a high 5-year survival rate. Risk factors such as high numbers of oral sex partners, disparities in smoking and drinking, and low rates of HPV vaccination may put gay and bisexual men at even higher risk for oropharyngeal cancer.
Methods: We recruited 21 healthcare providers in Minneapolis-St. Paul, Minnesota and Houston, Texas to participate in semi-structured interviews. Nurses, physician assistants, dental hygienists, and dentists were asked about their clinical experiences …
Identification Of Microbiological Factors Associated With Periodontal Health Disparities
Identification Of Microbiological Factors Associated With Periodontal Health Disparities
Faculty, Staff and Student Publications
The present study aimed at identifying risk factors associated with periodontitis development and periodontal health disparities with emphasis on differential oral microbiota. The prevalence of periodontitis is recently rising dentate adults in the US, which presents a challenge to oral health and overall health. The risk of developing periodontitis is higher in African Americans (AAs), and Hispanic Americans (HAs) than in Caucasian Americans (CAs). To identify potentially microbiological determinations of periodontal health disparities, we examined the distribution of several potentially beneficial and pathogenic bacteria in the oral cavities of AA, CA, and HA study participants. Dental plaque samples from 340 …
Influences Of Race/Ethnicity In Periodontal Treatment Response And Bacterial Distribution, A Cohort Pilot Study
Faculty, Staff and Student Publications
OBJECTIVES: Periodontitis disproportionately affects different racial and ethnic populations. We have previously reported the higher levels of
METHODS: This prospective cohort pilot study was carried out in an academic setting, at the School of Dentistry, University of Texas Health Science Center at Houston. Dental plaque was collected from a total of 75 African Americans, Caucasians and Hispanics periodontitis patients in a 3-year period. Quantitation of
RESULTS: The gains in clinical attachment levels after treatment significantly differed amongst the 3 groups-Caucasians responded most favorably, followed by African-Americans, lastly Hispanics, while numbers of
CONCLUSION: Differential response to nonsurgical periodontal treatment and distribution …
Application Of Implementation Mapping To Develop Strategies For Integrating The National Diabetes Prevention Program Into Primary Care Clinics, Catherine Pulicken, Pierre Fwelo, Grace E White, Belinda M Reininger, John W Mcwhorter, Roshanda Chenier, Maria E Fernandez
Application Of Implementation Mapping To Develop Strategies For Integrating The National Diabetes Prevention Program Into Primary Care Clinics, Catherine Pulicken, Pierre Fwelo, Grace E White, Belinda M Reininger, John W Mcwhorter, Roshanda Chenier, Maria E Fernandez
Faculty, Staff and Student Publications
BACKGROUND: Diabetes is considered one of the most prevalent and preventable chronic health conditions in the United States. Research has shown that evidence-based prevention measures and lifestyle changes can help lower the risk of developing diabetes. The National Diabetes Prevention Program (National DPP) is an evidence-based program recognized by the Centers for Disease Control and Prevention; it is designed to reduce diabetes risk through intensive group counseling in nutrition, physical activity, and behavioral management. Factors known to influence this program's implementation, especially in primary care settings, have included limited awareness of the program, lack of standard clinical processes to facilitate …
Application Of Implementation Mapping To Develop Strategies For Integrating The National Diabetes Prevention Program Into Primary Care Clinics, Catherine Pulicken, Pierre Fwelo, Grace E White, Belinda M Reininger, John W Mcwhorter, Roshanda Chenier, Maria E Fernandez
Application Of Implementation Mapping To Develop Strategies For Integrating The National Diabetes Prevention Program Into Primary Care Clinics, Catherine Pulicken, Pierre Fwelo, Grace E White, Belinda M Reininger, John W Mcwhorter, Roshanda Chenier, Maria E Fernandez
Faculty, Staff and Student Publications
BACKGROUND: Diabetes is considered one of the most prevalent and preventable chronic health conditions in the United States. Research has shown that evidence-based prevention measures and lifestyle changes can help lower the risk of developing diabetes. The National Diabetes Prevention Program (National DPP) is an evidence-based program recognized by the Centers for Disease Control and Prevention; it is designed to reduce diabetes risk through intensive group counseling in nutrition, physical activity, and behavioral management. Factors known to influence this program's implementation, especially in primary care settings, have included limited awareness of the program, lack of standard clinical processes to facilitate …
Developing And Pre-Testing A Digital Decision-Tree Smartphone Application For Smoking Prevention And Cessation Among Hiv Care Providers, Christine Markham
Developing And Pre-Testing A Digital Decision-Tree Smartphone Application For Smoking Prevention And Cessation Among Hiv Care Providers, Christine Markham
Faculty, Staff and Student Publications
OBJECTIVES: The diagnosis and continuous care of chronic conditions such as HIV infection present potential teachable moments for delivering smoking prevention and cessation interventions for patients. We designed and pre-tested a prototype of a smartphone application(app), Decision-T, specifically designed to assist healthcare providers when providing personalized smoking prevention and cessation services to their patients.
METHODS: We developed the Decision-T app based on transtheoretical algorithm for smoking prevention and cessation following the 5-A's model. We employed a mixed-methods approach among 18 HIV-care providers recruited from Houston Metropolitan Area for pre-testing the app. Each provider participated in three mock sessions, and the …
Do Breast Cancer Survivors With A Recent History Of Clinical Depression Report Worse Experiences With Care? A Retrospective Cohort Study Using Seer-Cahps Data, Melissa F Peskin
Do Breast Cancer Survivors With A Recent History Of Clinical Depression Report Worse Experiences With Care? A Retrospective Cohort Study Using Seer-Cahps Data, Melissa F Peskin
Faculty, Staff and Student Publications
PURPOSE: We examined whether breast cancer survivors' experiences with care differed by a recent history of clinical depression, and whether associations differed by race/ethnicity.
METHODS: Using the Epidemiology and End Results-Consumer Assessment of Healthcare Providers and Systems (SEER-CAHPS) dataset, we analyzed records of breast cancer survivors who completed a survey at least 12 months after their cancer diagnosis. We assessed clinical depression 12 months prior to survey completion using Medicare claims. We used separate multivariable logistic regressions to examine the associations between depression and excellent (vs. less than excellent) ratings of experiences with care (i.e., doctor communication, getting needed care, …
Susceptible Windows Of Exposure To Fine Particulate Matter And Fetal Growth Trajectories In The Spanish Inma (Infancia Y Medio Ambiente) Birth Cohort, Michael D Swartz, Albert Ambros, Marisa Estarlich, Aitana Lertxundi, Isolina Riano-Galán, Jordi Sunyer, Ana Fernandez-Somoano, Suneet P Chauhan, Jennifer Ish, Kristina W Whitworth
Susceptible Windows Of Exposure To Fine Particulate Matter And Fetal Growth Trajectories In The Spanish Inma (Infancia Y Medio Ambiente) Birth Cohort, Michael D Swartz, Albert Ambros, Marisa Estarlich, Aitana Lertxundi, Isolina Riano-Galán, Jordi Sunyer, Ana Fernandez-Somoano, Suneet P Chauhan, Jennifer Ish, Kristina W Whitworth
Faculty, Staff and Student Publications
While prior studies report associations between fine particulate matter (PM
Rf Coverage Planning And Analysis With Adaptive Cell Sectorization In Millimeter Wave 5g Networks, Md Maruf Ahamed
Rf Coverage Planning And Analysis With Adaptive Cell Sectorization In Millimeter Wave 5g Networks, Md Maruf Ahamed
Theses and Dissertations
The advancement of Fifth Generation Network (5G) technology is well underway, with Mobile Network Operators (MNOs) globally commencing the deployment of 5G networks within the mid-frequency spectrum range (3GHz–6GHz). Nevertheless, the escalating demands for data traffic are compelling MNOs to explore the high-frequency spectrum (24GHz–100GHz), which offers significantly larger bandwidth (400MHz-800 MHz) compared to the mid-frequency spectrum (3GHz–6GHz), which typically provides 50MHz-100MHz of bandwidth. However, it is crucial to note that the higher-frequency spectrum imposes substantial challenges due to exceptionally high free space propagation loss, resulting in 5G cell site coverage being limited to several hundred meters, in contrast to …
Expanding Medicaid To Reduce Human Immunodeficiency Virus Transmission In Houston, Texas: Insights From A Modeling Study, Marlene Mcneese, Salma Khuwaja, Babak M Ardestani, Nicholson Collier, Jonathan Ozik, Anna L Hotton, Nina T Harawa, John A Schneider, Kayo Fujimoto
Expanding Medicaid To Reduce Human Immunodeficiency Virus Transmission In Houston, Texas: Insights From A Modeling Study, Marlene Mcneese, Salma Khuwaja, Babak M Ardestani, Nicholson Collier, Jonathan Ozik, Anna L Hotton, Nina T Harawa, John A Schneider, Kayo Fujimoto
Faculty, Staff and Student Publications
CONTEXT: Medicaid expansion has been nationally shown to improve engagement in the human immunodeficiency virus (HIV) treatment and prevention continua, which are vital steps to stopping the HIV epidemic. New HIV infections in the United States are disproportionately concentrated among young Black men who have sex with men (YBMSM). Houston, TX, is the most populous city in the Southern United States with a racially/ethnically diverse population that is located in 1 of 11 US states that have not yet expanded Medicaid coverage as of 2021.
METHODS: An agent-based model that incorporated the sexual networks of YBMSM was used to simulate …
Which U.S. Executive Agency Is The Most Practical To Promulgate Space Debris Mitigation Regulations, And How Will The Space Debris Legal Framework Further Develop?, Tate Garvin Few
Theses and Dissertations
There is much dispute over which agency should take charge of creating and enforcingspace debris regulations. The controversy stems from the highly underdeveloped legal framework that is limited to the IADC guidelines, the Orbital Debris Mitigation Standard Practices (ODMSP), and Space Policy Directive-3. Currently, the Federal Communications Commission is attempting to take the lead role in this effort by establishing the new 5-year space debris disposal rule. However, it is argued that Congress did not declare it to be within their jurisdictional purview. Congress has not yet explicitly stated their intent to have a centralized authority in establishing relevant regulations …
Toward A More Comprehensive Understanding Of Organizational Influences On Implementation: The Organization Theory For Implementation Science Framework, Jure Baloh, Manal Masud, Terry T-K Huang, Matthew Lee, Mary Wangen, Per Nilsen, Miriam Bender, Mimi Choy-Brown, Grace Ryan, Aliza Randazzo, Linda K Ko
Toward A More Comprehensive Understanding Of Organizational Influences On Implementation: The Organization Theory For Implementation Science Framework, Jure Baloh, Manal Masud, Terry T-K Huang, Matthew Lee, Mary Wangen, Per Nilsen, Miriam Bender, Mimi Choy-Brown, Grace Ryan, Aliza Randazzo, Linda K Ko
Faculty, Staff and Student Publications
INTRODUCTION: Implementation is influenced by factors beyond individual clinical settings. Nevertheless, implementation research often focuses on factors related to individual providers and practices, potentially due to limitations of available frameworks. Extant frameworks do not adequately capture the myriad organizational influences on implementation. Organization theories capture diverse organizational influences but remain underused in implementation science. to advance their use among implementation scientists, we distilled 70 constructs from nine organization theories identified in our previous work into theoretical domains in the Organization Theory for Implementation Science (OTIS) framework.
METHODS: The process of distilling organization theory constructs into domains involved concept mapping and …
From The National To The Local: Issues Of Trust And A Model For Community-Academic-Engagement, Sarah Piepenbrink, Desiree De La Torre, Shannon Guillot-Wright, Marshala Lee
From The National To The Local: Issues Of Trust And A Model For Community-Academic-Engagement, Sarah Piepenbrink, Desiree De La Torre, Shannon Guillot-Wright, Marshala Lee
Faculty, Staff and Student Publications
Inequities in health and health care in the United States have persisted for decades, and the impacts on equity from the COVID-19 pandemic were no exception. In addition to the disproportionate burden of the disease across various populations, the pandemic posed several challenges, which exacerbated these existing inequities. This has undoubtedly contributed to deeply rooted public mistrust in medical research and healthcare delivery, particularly among historically and structurally oppressed populations. In the summer of 2020, given the series of social injustices posed by the pandemic and highly publicized incidents of police brutality, notably the murder of George Floyd, the Association …
Transcription Factor E2f1 Regulates The Expression Of Adrb2, Jin Shu
Transcription Factor E2f1 Regulates The Expression Of Adrb2, Jin Shu
Faculty, Staff and Student Publications
Adrenergic beta-2-receptor (ADRB2) is highly expressed in various tissue cells, affecting the susceptibility, development, and drug efficacy of diseases such as bronchial asthma and malignant tumor. However, the transcriptional regulatory mechanism of the human ADRB2 gene remains unclear. This study aimed to clarify whether E2F transcription factor 1 (E2F1) was involved in the transcriptional regulation of the human ADRB2 gene. First, the 5' flanking region of the human ADRB2 gene was cloned, and its activity was detected using A549 and BEAS-2B cells. Second, it was found that the overexpression of E2F1 could increase promoter activity by a dual-luciferase reporter gene …
Wastewater Pandemic Preparedness: Toward An End-To-End Pathogen Monitoring Program, Juwan Cormier, Kristi Louise Hoffman, Catherine Troisi, Blake Hanson, Joseph Petrosino, John Balliew, Pedro A Piedra, Janelle Rios, Jennifer Deegan, Cici Bauer, Fuqing Wu, Kristina D Mena, Eric Boerwinkle, Anthony W Maresso
Wastewater Pandemic Preparedness: Toward An End-To-End Pathogen Monitoring Program, Juwan Cormier, Kristi Louise Hoffman, Catherine Troisi, Blake Hanson, Joseph Petrosino, John Balliew, Pedro A Piedra, Janelle Rios, Jennifer Deegan, Cici Bauer, Fuqing Wu, Kristina D Mena, Eric Boerwinkle, Anthony W Maresso
Faculty, Staff and Student Publications
Molecular analysis of public wastewater has great potential as a harbinger for community health and health threats. Long-used to monitor the presence of enteric viruses, in particular polio, recent successes of wastewater as a reliable lead indicator for trends in SARS-CoV-2 levels and hospital admissions has generated optimism and emerging evidence that similar science can be applied to other pathogens of pandemic potential (PPPs), especially respiratory viruses and their variants of concern (VOC). However, there are substantial challenges associated with implementation of this ideal, namely that multiple and distinct fields of inquiry must be bridged and coordinated. These include engineering, …
Digital Solutions Observed In Clinical Trials: A Formative Feasibility Scoping Review, Hongfang Liu
Digital Solutions Observed In Clinical Trials: A Formative Feasibility Scoping Review, Hongfang Liu
Faculty, Staff and Student Publications
Growing digital access accelerates digital transformation of clinical trials where digital solutions (DSs) are increasingly and widely leveraged for improving trial efficiency, effectiveness, and accessibility. Many factors impact DS success including technology barriers, privacy concerns, or user engagement activities. It is unclear how those factors are considered or reported in the literature. Here, we perform a formative feasibility scoping review to identify gaps impacting DS quality and reproducibility in trials. Articles containing digital terms published in English from 2009 to 2022 were collected (n=4,167). 130 articles published between 2016 and 2022 were randomly selected for full-text review. Eligible articles (n=100) …
Contextual Variation Of Clinical Notes Induced By Ehr Migration
Contextual Variation Of Clinical Notes Induced By Ehr Migration
Faculty, Staff and Student Publications
The structure and semantics of clinical notes vary considerably across different Electronic Health Record (EHR) systems, sites, and institutions. Such heterogeneity hampers the portability of natural language processing (NLP) models in extracting information from the text for clinical research or practice. In this study, we evaluate the contextual variation of clinical notes by measuring the semantic and syntactic similarity of the notes of two sets of physicians comprising four medical specialties across EHR migrations at two Mayo Clinic sites. We find significant semantic and syntactic variation imposed by the context of the EHR system and between medical specialties whereas only …