Digital Commons Network^™

Photoplethysmography-New Applications For An Old Technology: A Sleep Technology Review, Arvind Chandrakantan, Nitun Verma, Steven Holfinger, Fariha Abbasi-Feinberg, Anuja Bandyopadhyay, Kelly Baron, Sumit Bhargava, Ken He, Joseph Kern, Jennifer Miller, Ruchir Patel, Dulip Ratnasoma, Maryann C Deak

Faculty, Staff and Students Publications

Education is integral to the American Academy of Sleep Medicine (AASM) mission. The AASM Emerging Technology Committee identified an important and evolving piece of technology that is present in many of the consumer and clinical technologies that we review on the AASM #SleepTechnology (https://aasm.org/consumer-clinical-sleep-technology/) resource—photoplethysmography. As more patients with sleep tracking devices ask clinicians to view their data, it is important for sleep providers to have a general understanding of the technology, its sensors, how it works, targeted users, evidence for the claimed uses, and its strengths and weaknesses. The focus in this review is photoplethysmography—a sensor type …

Documents From The December 6, 2024 Meeting Of The Associated Students Of The University Of Montana (Asum), University Of Montana--Missoula. Associated Students

Senate Meeting Agendas and Minutes, 2007-Present

Agenda and meeting minutes from the December 6, 2024 meeting of the Associated Students of the University of Montana (ASUM).

Quantitative Measurement Of Protac Intracellular Accumulation

Faculty, Staff and Students Publications

In recent years, Proteolysis Targeting Chimera (PROTAC) technology has emerged as one of the most promising approaches to remove disease-associated proteins by utilizing cells' own destruction machinery. To achieve successful degradation of a protein of interest (POI), the heterobifunctional PROTAC molecules must penetrate into the cells first, followed by target engagement and formation of the POI-PROTAC-E3 ligase complex. Based on this understanding, the assessment of cell permeability and in cell target engagement are of great importance to evaluate the efficacy of PROTAC candidates. PROTAC molecules can be classified as non-covalent and covalent, and covalent PROTACs can be further divided into …

Advanced Photon Counting Ct Imaging Pipeline For Cardiac Phenotyping Of Apolipoprotein E Mouse Models, Yi Qi, Zay Y Han, Prajwal Bhandari, Ketan B Ghaghada, Alexandra Badea, Cristian T Badea

Faculty, Staff and Students Publications

Background: Cardiovascular disease (CVD) is associated with the apolipoprotein E (APOE) gene and lipid metabolism. This study aimed to develop an imaging-based pipeline to comprehensively assess cardiac structure and function in mouse models expressing different APOE genotypes using photon-counting computed tomography (PCCT).

Methods: 123 mice grouped based on APOE genotype (APOE2, APOE3, APOE4, APOE knockout (KO)), gender, human NOS2 factor, and diet (control or high fat) were used in this study. The pipeline included PCCT imaging on a custom-built system with contrast-enhanced in vivo imaging and intrinsic cardiac gating, spectral and temporal iterative reconstruction, spectral decomposition, and deep learning cardiac …

Clinical Efficacy Among Patients With Chronic Rhinosinusitis With Nasal Polyps And Clinical Features Of Obstructive Lung Disease: Post Hoc Analysis Of The Phase Iii Sinus-24 And Sinus-52 Studies, Nicola A Hanania, Benjamin Ortiz, Naimish Patel, Leda P Mannent, Amy Praestgaard, Nami Pandit-Abid, Shahid Siddiqui, Megan Hardin

Faculty, Staff and Students Publications

PURPOSE: To provide a descriptive summary of clinical efficacy and health-related quality of life (HRQoL) measures in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and clinical features of obstructive lung disease in the Phase III dupilumab studies SINUS-24 and SINUS-52 (NCT02912468, NCT02898454).

PATIENTS AND METHODS: Patients met a "broad" definition of having clinical features of obstructive lung disease with any of 3 criteria: (i) pre-bronchodilator forced expiratory volume in 1 second (FEV

RESULTS: Across both studies, 131 patients met the "broad" definition, of whom 90 also had asthma, and 115 patients met the "narrow" definition, of whom 74 had …

The Small Intestinal Microbiome: Vibing With Intestinal Stem Cells

Faculty, Staff and Students Publications

The epithelial lining of the small intestine mediates its absorptive and secretory function and thus is a critical component of human health. Regeneration and renewal of the epithelium is the result of proliferation of intestinal stem cells (ISCs). Many cell types and molecular factors are known to regulate the ability of ISCs to proliferate, including adjacent neighboring epithelial cells and the underlying, supportive stromal cells. The microbiome resides in the lumen of the small intestine and is in close contact with the epithelium. Due to its proximity to ISCs, it has been hypothesized that species within the microbiome have the …

The Use Of Reframing: Increasing The Importance Of Lifestyle Medicine, Craig A Johnston

Faculty, Staff and Students Publications

Lifestyle behavior modification is an essential component to prevention and treatment of non-communicable diseases worldwide. For the last 40 years, studies have recognized that there is suboptimal training of physicians in lifestyle medicine and its implementation in clinical settings. The lack of nutrition and exercise counseling occurring in the medical office does not reflect the high level of evidence supporting its use. Lifestyle behavior counseling is complex; as are the individualized needs of patients. Therefore, we suspect that the lack of knowledge in nutrition and exercise prescriptions are not the only barriers to providing optimal care. Reframing lifestyle medicine interventions …

Habenular Molecular Targets For Depression, Impulsivity, And Addiction

Faculty, Staff and Students Publications

No abstract provided.

Impact Of Gastrointestinal Polymerase Chain Reaction Panels On Antibiotic Utilization In Hospitalized Adult Patients, Amna Ahmed, Krithika Srinivasan, Jesica Hayon, Todd Lasco, Rosie Amini, Sabra Shay, Prathit A Kulkarni, Mayar Al Mohajer

Faculty, Staff and Students Publications

Multiplex stool polymerase chain reaction (PCR) panels offer rapid comprehensive testing for patients with infectious diarrhea. We compared antibiotic utilization among hospitalized patients with suspected infectious diarrhea who underwent diagnostic testing with either a stool culture or stool PCR panel. No significant differences in antibiotic utilization were identified.

Pattern-Based Target Selection For Treatment Of Irregular Past Tense: A Single-Case Experimental Design For Children With Developmental Language Disorder, Kirsten M. Russell, Amy Wilder, Julie L. Wambaugh

Faculty Publications

Purpose: Many children with developmental language disorder (DLD) demonstrate
difficulty inflecting irregular past tense verbs. We evaluated using phonological-
based patterns (i.e., schemas) to select targets for treatment of irregular verb inflection for children with DLD. We hypothesized this approach would result in acquisition of treated verbs, generalization to untreated verbs within the same phonological schema, and increased use of correct irregular verbs in naturalistic contexts. Method: Treatment was provided to three 7-year-old participants with DLD in the context of multiple baseline designs across behaviors and participants. Phonological schemas included vowel change, final alveolar, and dual change irregular verbs. Treatment …

Adaptive Reuse Of The Suburban Office Building, Olivia Mora

Architecture Theses and Projects

My thesis addresses the current issues of office vacancy and the housing shortage. Living in the Portland, Maine area my entire life, I’ve noticed a lot of gentrification happening in the city downtown, including my dad’s little neighborhood he grew up in. I want to create a space where people of all incomes levels have the opportunity to live in.

After a thorough GIS analysis, the ideal site was determined to be 300 Southborough Drive in South Portland. This is only 10-15 minutes from downtown Portland. When adapting a vacant, standalone suburban office building like this one, there are a …

Factors Influencing The Relationship Between The Latinx Community And Law Enforcement, Silvia Gramajo Mazariegos

Social Justice | Senior Theses

The study has quantitative and qualitative aspects. The quantitative aspect measures how attitudes toward law enforcement and fear are related and how attitudes toward law enforcement and willingness to seek help from law enforcement are related. The qualitative aspect explores how trust plays a role in the relationship between the Latinx community and law enforcement. The qualitative aspect of the study also seeks to address how the overall relationship between the Latinx community and law enforcement can be improves. Participants completed a quantitative survey that measured their attitudes towards law enforcement, fear towards law enforcement, and willingness to accept help …

The Role Of Mentoring In The Lives Of Underrepresented Youth, Nohely Camacho Morales

Social Justice | Senior Theses

Underrepresented youth (Latino, Black, Pacific Islander, and Native American) face challenges in school enrollment/completion and often lack feelings of belonging in educational and social institutions. One specific group of underrepresented youth who face unique struggles is unaccompanied youth. Mentoring, a non-parental relationship between a young person and someone who supports and guides youth, has been found to result in better well-being and health in adolescents and potentially lead to higher self-worth and better academic performance. In order to fill a gap in the literature examining the effects of mentoring on underrepresented youth and specifically unaccompanied youth, I conducted a mixed-methods …

The Digital Divide: The Path Towards Digital Inclusivity, Angelica Gonzalez Almanza

Social Justice | Senior Theses

The gap between those Americans who use or have access to ICTs and those who do not is referred to as the digital divide (PACEs, 2002). The pandemic has increased dependence on technology and exacerbated the digital divide, which perpetuates existing systems of racism and poverty (Early et al., 2021). In this study, a mixed-method approach was conducted to understand what digital literacy skills parents need to overcome the digital divide and support their child's education. Specifically, the study explored how the program Impact Technology training has affected parents' involvement with their child's education. There were 175 Latinx parents that …

Exploring The Effects Of Different Types Of Diets On Preventing And Managing Diabetes Mellitus Type 2, Ma. Patricia Diorel Peig

Nursing | Senior Theses

Diabetes is a major health problem that is becoming an epidemic in major countries of the world. Diabetes can affect people of all ages and of all races. However, there is a higher risk of developing diabetes for certain groups of people. As of today, there is still no cure for diabetes. The treatment plan for patients diagnosed with diabetes is to control the level of blood glucose through different interventions. The progression of diabetes is influenced by food behaviors, and diet control is an important aspect of management of this disease. There are different types of diet recommended that …

Barriers To Obtaining Healthcare In The United States, Nikita Laungani

Nursing | Senior Theses

One barrier to obtaining healthcare in the United States (U.S.) has been the type of healthcare insurance that someone has. It is important for nurses to understand the impact of the patient’s access to care, which is a factor in their health outcomes. Health insurance, race and ethnicity, income, and zip code are at the top of a long list of social determinants of health that affects where and how they receive care. To find out more about how barriers to obtaining healthcare affect outcomes, I researched various types of barriers around the country. It is important to understand how …

Using Family Focused-Care Solutions To Improve Child’S Quality Of Life, Joshua M. Del Sol

Nursing | Senior Theses

Chronic illness in children impacts not only themselves but their families too. Everyone in the family supports each other and provides each other with pretty much all our physiological needs including our emotional needs. Parents/caregivers are the role models for their young children and really shape the person they become because basic values and their early relationships are formed. A family provides that consistent balance in our life that is the center of our life at a young age. When children are diagnosed with a chronic illness, parents may feel responsible, ashamed, guilty, or angry. Families may turn on each …

Kangaroo Care Education For Low Socioeconomic Status Families In The Neonatal Intensive Care Unit., Joara Peterson

Nursing | Senior Theses

The early contact between mother and baby is known as skin-to-skin, also referred to as “kangaroo care” (KC). It involves placing the baby on the mother’s chest as soon as it is appropriate (Thompson et al., 1979). This interaction was primarily for bonding but many researchers have discovered additional benefits. There is significant correlation between kangaroo care and weight gain (especially for low birth weight infants), as well as body temperature and heart rate regulation, which reduces the risk of medical complications. It also decreases levels of stress in mothers and babies by lowering the release of cortisol hormone (Mohammadi …

The Effects Of Prolonged Exposure Therapy On The Symptoms Of Patients With Posttraumatic Stress Disorder, Hannah Belle Pontillas

Nursing | Senior Theses

The Diagnostic and Statistical Manual of Mental Disorders or DSM-5 defines posttraumatic stress disorder or PTSD as persistent psychophysiological reactions including intrusive memories of trauma, negative feelings towards such memories, and avoidance of related stimuli—all of which are a direct result of experiencing a traumatic event. The first line of treatment for this particular mental disorder is considered to be prolonged exposure therapy or PE therapy due to its high success rate in treating the symptoms of moderate to severe PTSD as it encourages patients to directly confront and overcome their trauma. However, PE therapy has garnered concern as it …

Medically Accurate Evidence-Based Sex Education And Abstinence-Only Sex Education: Impact On Teen Pregnancies In The United States, Nicole Chiu

Nursing | Senior Theses

The U.S. has funded abstinence-only programs to combat pregnancy rates for a long time. With numerous factors contributing to teen pregnancies, there have been a lot of ways that people have decided to try to decrease the number of teen pregnancies. For example, schools have either decided that they intend to fully educate their teenage students using medically accurate evidence-based sex education or come from a more conservative approach and give abstinence-only education. The objective of this investigation is to identify whether evidence-based sex education or abstinence-only sex education is more effective at combating teen pregnancy and abortion rates. This …

Youth Transitions Advisory Council 2023 Annual Report, Tennessee. Commission On Children And Youth.

Youth Transitions Advisory Council

No abstract provided.

Law As Persuasion, Bert I. Huang

Faculty Scholarship

When does the law persuade us about what is right or wrong – and when does it not? On topics ranging from racial equality to abortion to same-sex marriage, historians have debated and puzzled over the law’s persuasive force on our collective moral intuitions. Meanwhile, other scholars have sought out individual-level insights into the psychology of law’s persuasion, under the microscope of controlled experiments.

This chapter presents evidence of the law’s influence on our moral intuitions in a survey experiment based on a classic dilemma known as the “trolley problem,” in which someone must make a choice about whether to …

Navigating Between "Politics As Usual" And Sacks Of Cash, Daniel C. Richman

Faculty Scholarship

Like other recent corruption reversals, Percoco was less about statutory text than what the Court deems “normal” politics. As prosecutors take the Court’s suggestions of alternative theories and use a statute it has largely ignored, the Court will have to reconcile its fears of partisan targeting and its textualist commitments

Child Development And The Family Regulation System, Clare Huntington

Faculty Scholarship

Child abuse and neglect clearly harm children, but the risks that accompany involvement with the family regulation system (also known as the child welfare system), especially placement in foster care, also present considerable risks to child development. This chapter describes these competing risks to child development, the legal framework governing the family regulation system, and scholarly debates in the field. It then analyzes the system in the broader context of the legal regulation of children, showing that the family regulation system is out of step with other areas and in need of significant reform. A core problem with the system …

Contract Production In M&A Markets, Stephen J. Choi, Mitu Gulati, Matthew Jennejohn, Robert E. Scott

Faculty Scholarship

Contract scholarship has devoted considerable attention to how contract terms are designed to incentivize parties to fulfill their obligations. Less attention has been paid to the production of contracts and the tradeoffs between using boilerplate terms and designing bespoke provisions. In thick markets everyone uses the standard form despite the known drawbacks of boilerplate. But in thinner markets, such as the private deal M&A world, parties trade off costs and benefits of using standard provisions and customizing clauses. This Article reports on a case study of contract production in the M&A markets. We find evidence of an informal information network …

Understanding Intellectual Property: Expression, Function, And Individuation, Mala Chatterjee

Faculty Scholarship

Underlying the fundamental structure of intellectual property law — specifically, the division between copyright and patent law — are at least two substantive philosophical assumptions. The first is that artistic works and inventions are importantly different, such that they warrant different legal systems: copyright law on the one hand, and patent law on the other. And the second is that particular artistic works and inventions can be determinately individuated from each other, and can thereby be the subjects of distinct and delineated legal rights. But neither the law nor existing scholarship provides a comprehensive analysis of these categories, what distinguishes …

Exploring Growth, Integration, & Play Working In Clay: Finding Pathways To Healing And Hope, Dana A. Bridges

Graduate Theses/Dissertations

I find therapeutic qualities in all the aspects of my studio practice and haptic experience: from the grounding sensory experience of clay, the quiet meditative motions of creating and constructing, acceptance or repair of mistakes, and the integration of failures which may occur. Specifically, I channel my experience to explore the themes of growth, integration, and play. By exploring these themes in the quiet and safety of my clay-studio, I engage in the opportunity to investigate these themes on a formal, practical, and personal level. I create the forms by hand or on the potter’s wheel. After constructing the forms, …

Insulin Is My Fuel, Jean Paul Vivas

Graduate Theses/Dissertations

The assertion that moments of play empower individuals to find balance amidst the tension of creation and destruction is a central tenet of my artistic philosophy. Through the expressive medium of painting, I have discovered that playfulness can serve as a responsive process that facilitates a flexible approach to coping with the complexities of identity, ideology, and morality. This fertile ground for creativity has become a means of defining a sense of life that is informed by my ongoing struggles with a diabetic medical condition. As my body's dependency on insulin necessitates a constant movement between the frustrations of daily …

In Between Lines: An Investigation Of The Ghanaian Migration Experience, Teddy Osei

Graduate Theses/Dissertations

As my socio-cultural experiences continue to evolve, so does my interest in contemporary border discourses. The question of ''who qualifies to be where and how,'' lingers in my mind daily as I reflect on my migration experience as a Ghanaian living in the United States of America. Another area of interest is the social and physical challenges endured by individuals transitioning from one geographic location to another.In replicating these experiences, I make ceramic sculptural vessels associated with sojourning. In my ceramic sculptures, I use specific elements, such as ropes and Ghana must-go bags, which honor Africa's past and its people …

A Part From You, Kenneth Rick Briggenhorst Jr.

Graduate Theses/Dissertations

I invite empathy through art that is technologically assisted to find alternative interpretations for nontheologically informed faith. The sudden passing of my dearest friend, Jimmy, encouraged me to dig through my archives of data, to cherish all the bytes that remain of him. In this endeavor, I find that death is not the end, but a post-physical state of being. I express this sentiment in a part from you, where the work utilizes inanimate constructs to place your faith in, to make sense of the complexities of grief in a digitally tethered way of life. This life that allows many …