Digital Commons Network^™

Sustainable Solution For Plastic Waste Management And Education Campaigns To Mitigate Plastic Consumption And Foster Behavior Change, Mayowa Akande

Masters Theses

The issue of plastic waste has become a significant environmental concern in contemporary times. Given the escalating rates of plastic production and consumption worldwide, an urgent need is to implement effective strategies to manage plastic waste. This article aims to investigate sustainable strategies for managing plastic waste through an analysis of existing research and exemplary approaches in the domain. This research assesses diverse methodologies, such as recycling, waste minimization, biodegradable substitutes, and policy interventions, and appraises their efficacy, obstacles, and prospects for enduring sustainability. The results of this research emphasize the significance of inclusive and cohesive approaches that engage various …

Visualizing The Risks: The Significance Of Graphic Design In Educating Women About The Risks Of Prescription Opioids & Pre-Existing Mental Health Conditions, Natascha Foret Truong

Masters Theses

This thesis explores the critical issue of educating women about the increased risks of prescription opioid use and misuse relating to a co-occurring mental health illness. The research-based graphic design solutions proposed in the thesis aim to create awareness and provide knowledge to women on this matter. It is imperative to address this issue as it has severe consequences for women, their families, and society. This thesis utilizes research and best practices from scholarly articles, case studies, visual analysis, personas, and mind mapping to present graphic design solutions based on evidence. These solutions aim to educate women about the gender-specific …

A Comparative Analysis Of The Doctrine Of Bodily Resurrection In Jehovah's Witnesses Versus Traditional Christianity, Carey A. Murphy

Masters Theses

The present thesis aims to provide a critical analysis of the immaterial resurrection proposed by the Governing Body of the Watchtower Bible and Tract Society and, in doing so, demonstrates the superiority of the orthodox Christian position on the bodily resurrection because of its consideration of key aspects such as Christology, the resurrection, gospel, and eschatology. The first chapter explains how the Watchtower Bible and Tract Society became a global religious organization. In chapter two, Jehovah's Witness documentation on the immaterial resurrection of Christ is presented, with occasional commentary on issues. Chapter three delves into the historical perspective of the …

The Miracles Of Christ And Kṛṣṇa And The Authority To Redeem Creation, Sallie R. Fuller

Masters Theses

The purpose of this study is not to prove the veracity of miracle claims of Jesus in the Bible, nor to disprove those of Kṛṣṇa in the Śrīmad Bhāgavata Mahāpurāṇa. Rather, the research for this thesis reviews the miracles of Jesus and Kṛṣṇa as documented in their respective scriptures to determine which can authoritatively claim to be God, the Creator of the universe, and thus the one true source of the miraculous on Earth. Further, both claim to be not only God the Creator but Savior. It is the contention here that the Creator has the desire to redeem and …

Synthesis And In‑Vitro Anti‑Proliferative With Antimicrobial Activity Of New Coumarin Containing Heterocycles Hybrids, Elbadawy A. Kamoun, Elbadawy A. Kamoun

Nanotechnology Research Centre

series of new coumarin-N-heterocyclic hybrids, coumarin-quinolines 7a–e, coumarin-acridines 10b,c and coumarin-neocryptolepines 13b,c were synthesized and evaluated for their anticancer and antimicrobial activities. The structures of all synthesized hybrids were confirmed by FT-IR, 1HNMR, 13C-NMR, and MS spectrometry. The anti-proliferative activity of hybrids 7a–e, 10c and 13c were bio-evaluated using MTT-assay against colon (CaCo-2), lung (A549), breast (MDA-MB-231), and hepatocellular carcinoma (HepG-2) human cancer cell lines using doxorubicin as a reference drug. The results demonstrated that, all hybrids displayed moderate to good anti-proliferative activity against the cell lines. The most active hybrids were 7a–d and 10c against CaCo-2 cancer cell line …

Risk Factors For Unplanned Readmissions In Paediatric Neurosurgery: A Systematic Review Protocol, Lance Vincent Caburian Sese, Ma Celina Legaspi Guillermo

Ateneo School of Medicine and Public Health Publications

Introduction Unplanned hospital readmission (UHR) following surgical procedures reflects patient outcomes. While adult readmission studies are abundant, limited research exists in paediatric populations, especially in the context of neurosurgery. Methods and analysis This protocol outlines a systematic review aimed at identifying reasons for unplanned readmissions (30-day and 90-day readmissions) and risk factors following paediatric neurosurgical procedures. Narrative synthesis, sensitivity analyses, subgroup analyses, and meta-analysis, when appropriate, will be done. Ethics and dissemination There are no primary data involved and no access to confidential patient information. The findings aim to contribute to refining clinical practice, enhance patient counselling, and optimise healthcare …

Visualizing Visual Neural Pathways In Virtual Reality A Neuroanatomy Tool, Mary Nguyen

Theses

Visualizing the human brain and its structures in three dimensions is a complex and overwhelming task. Sensory pathways such as visual neural pathways, are important but difficult to visualize. With the rising popularity of extended reality (XR) in modern education, a Neuroanatomy tool in virtual reality (VR) was developed to allow students and other learners to explore the human brain and learn about its functions in an engaging way. Virtual reality enables a user to have the ability to visualize complex structures in the brain in a way that is otherwise impossible to see in a cadaver lab or web-based …

International Engagement Newsletter, December 19, 2023, University Of Northern Iowa. Office Of International Engagement.

Office of International Engagement newsletter

In this issue:

--- Happy Winter Break
--- Congrats: New International Graduates
--- Holiday Hoopla
--- OIE Winter Break Schedule
--- Tips from Our Director

Project Information Standard – File Naming, Robert Moore

Tools

Project Information Standard – File Naming is a support in a spreadsheet format that contains a number of templates that give guidance on file naming in accordance with the Irish National Annexe to ISO 19650-2.

Build Digital has created Industry templates to allow organisations work in accordance with ISO 19650. These templates start to address the information requirements in the ISO 19650 series of standards. The templates are also in accordance with CEN-TR17654-2021” Guideline for the implementation of Exchange Information Requirements (EIR)and BIM Execution Plans (BEP) on European level based on EN ISO 19650-1 and -2”. Aspects of the Templates …

Evaluation Of Koopman Operator Neural Decoding Scheme, Kyle Edwards

Electronic Theses and Dissertations Archive

Neural activity correlates with a wide variety of phenomena relating to the animal originating the activity. It is possible to exploit those correlations by measuring the activity and mathematically transforming it via a so-called decoding process to determine what, physically, the activity represented. The signals measured are typically nonlinear, and though classical statistical techniques exist for handling these signals, increasingly influential methods including neural networks and the Koopman operator formalism provide new avenues to explore for handling such nonlinear problems. We propose a method of decoding utilizing a neural network representation of the Koopman operator and test it on the …

Paleoindian Utilization Of Allendale Chert Deposits Along The Savannah River, Hunter Blake Saunders

Electronic Theses and Dissertations Archive

Outcrops of Allendale chert, along the Savannah River, can be characterized with the use of high-resolution chert provenance data in order to study inter-quarry procurement strategies, social networks, and mobility. The thesis presents results of sourcing methods using reflectance spectroscopy. Chert sourcing is a viable technique for determining Paleo-Indian behavior in relation to the use and procurement of stone tools. Reflectance spectroscopy is a non-destructive method used in archaeology to determine the source of chert artifacts. A combination of two instruments is used in the study to quantify and separate source variability of Allendale chert utilized by Paleoindians. Reflectance spectroscopy …

With Regard For Persons, William Boyd

Law and Contemporary Problems

No abstract provided.

Pkc-Delta-I Inhibitor Formulations And Uses Thereof, Niketa A. Patel, Rekha S. Patel, Robert Pleasants Sparks, Wayne Charles Guida

USF Patents

Provided herein are formulations that can contain an effective amount of a PKCδ inhibitor. Also provided herein are methods of inhibiting a PKCδ in a subject in need thereof, that can include the step of administering an effective amount of a compound that is capable of inhibiting a PKCδ.

Strategy To Increase Anti-Viral, Anti-Microbial, And Anti-Fungal Defense, Hana Totary-Jain

USF Patents

Disclosed herein are compositions and methods for inducing, promoting, or enhancing an immune response in a subject. For example, the disclosed compositions and methods can be used prophylactically to prevent viral/microbial infections or therapeutically to treat acute infections. In some embodiments, the disclosed method involves administering to the subject a composition comprising in vitro transcribed (IVT) RNA comprising short interspersed nuclear elements (SINEs), such as Alu repeats. In some embodiments, the disclosed compositions and methods can be used to induce, promote, or enhance any immune response in a subject, including an anti-viral, anti-microbial, anti-fungal, or anti-parasite response. In some embodiments, …

A Large-Scale Experiment Finds No Consistent Evidence Of Change In Mortality Or Commercial Productivity In Silverlip Pearl Oysters (Pinctada Maxima) Exposed To A Seismic Source Survey, Miles J G Parsons, Diego R. Barneche, Conrad W. Speed, Robert D. Mccauley, Ryan D. Day, Cecile Dang, Rebecca Fisher, Hosna Gholipour-Kanani, Stephen J. Newman

Fisheries Research Articles

High-intensity, impulsive sounds are used to locate oil and gas reserves during seismic exploration of the seafloor. The impacts of this noise pollution on the health and mortality of marine invertebrates are not well known, including the silverlip pearl oyster (Pinctada maxima), which comprises one of the world's last remaining significant wildstock pearl oyster fisheries, in northwestern Australia. We exposed ≈11,000 P. maxima to a four-day experimental seismic survey, plus one vessel-control day. After exposure, survival rates were monitored throughout a full two-year production cycle, and the number and quality of pearls produced at harvest were assessed. Oysters from two …

The Problem Of Deification Within The Church Context In India: An Implausible Deification, Sadananda Rao Matangi

Masters Theses

The self-deification has been the main point on which several related issues have been discussed. No humans are equal with God but are only the servants of God. Even Jesus Christ agreed that the Father is greater than He. The concept of self-deification cannot be used overtly or covertly for self-elevation, Sacro-egoism, Sacro-egotism, self-advantage, or self-probability. On accepting Jesus as one’s personal Lord and Savior, a person may get the blessing of forgiveness of sins, sanctification, salvation, filling of the Holy Spirit, assurance of resurrection, and being with the Lord (on the Second Coming). That does not mean they are …

Extended-Synaptotagmin-1 And -2 Control T Cell Signaling And Function, Nathalia Benavides, Claudio G. Giraudo

Department of Microbiology and Immunology Faculty Papers

Upon T-cell activation, the levels of the secondary messenger diacylglycerol (DAG) at the plasma membrane need to be controlled to ensure appropriate T-cell receptor signaling and T-cell functions. Extended-Synaptotagmins (E-Syts) are a family of inter-organelle lipid transport proteins that bridge the endoplasmic reticulum and the plasma membrane. In this study, we identify a novel regulatory mechanism of DAG-mediated signaling for T-cell effector functions based on E-Syt proteins. We demonstrate that E-Syts downmodulate T-cell receptor signaling, T-cell-mediated cytotoxicity, degranulation, and cytokine production by reducing plasma membrane levels of DAG. Mechanistically, E-Syt2 predominantly modulates DAG levels at the plasma membrane in resting-state …

Regulation As Respect, Cristie Ford

Law and Contemporary Problems

No abstract provided.

The Anti-Managerial Information Commission, Margaret B. Kwoka

Law and Contemporary Problems

No abstract provided.

Introduction: Framing Regulatory Managerialism As An Object Of Study And Strategic Displacement, Julile E. Cohen, Ari Ezra Waldman

Law and Contemporary Problems

No abstract provided.

Needle Biopsy Accelerates Pro-Metastatic Changes And Systemic Dissemination In Breast Cancer: Implications For Mortality By Surgery Delay, Hiroyasu Kameyama, Priya Dondapati, Reese Simmons, Macall Leslie, John Langenheim, Yunguang Sun, Misung Yi, Aubrey Rottschaefer, Rashmi Pathak, Shreya Nuguri, Kar-Ming Fung, Shirng-Wern Tsaih, Inna Chervoneva, Hallgeir Rui, Takemi Tanaka

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

ncreased breast cancer (BC) mortality risk posed by delayed surgical resection of tumor after diagnosis is a growing concern, yet the underlying mechanisms remain unknown. Our cohort analyses of early-stage BC patients reveal the emergence of a significantly rising mortality risk when the biopsy-to-surgery interval was extended beyond 53 days. Additionally, histology of post-biopsy tumors shows prolonged retention of a metastasis-permissive wound stroma dominated by M2-like macrophages capable of promoting cancer cell epithelial-to-mesenchymal transition and angiogenesis. We show that needle biopsy promotes systemic dissemination of cancer cells through a mechanism of sustained activation of the COX-2/PGE₂/EP2 feedforward loop, …

Biomarkers Of Affective Dysregulation Associated With In Utero Exposure To Etoh, Nune Darbinian, Nana Merabova, Gabriel Tatevosian, Mary Morrison, Armine Darbinyan, Huaqing Zhao, Laura Goetzl, Michael Edgar Selzer

Faculty, Staff and Student Publications

INTRODUCTION: Children with fetal alcohol spectrum disorders (FASD) exhibit behavioral and affective dysregulation, including hyperactivity and depression. The mechanisms are not known, but they could conceivably be due to postnatal social or environmental factors. However, we postulate that, more likely, the affective dysregulation is associated with the effects of EtOH exposure on the development of fetal serotonergic (5-HT) and/or dopaminergic (DA) pathways, i.e., pathways that in postnatal life are believed to regulate mood. Many women who use alcohol (ethanol, EtOH) during pregnancy suffer from depression and take selective serotonin reuptake inhibitors (SSRIs), which might influence these monoaminergic pathways in the …

Pain Management By Chemogenetic Control Of Sensory Neurons, Yize Li, Xin Ge, Ru-Rong Ji

Faculty, Staff and Student Publications

In this study, Perez-Sanchez et al.1 developed a chemogenetic method aimed at alleviating pain in mouse models while dampening excitability in human sensory neurons. This analgesic effect was attained through the introduction of human α7 nicotinic acetylcholine receptor and glycine receptor pore domain via virus-mediated expression in sensory neurons, forming a chloride channel. The activation of this channel was made possible by specific agonists. This study highlights the potential for treating clinical pain by gene therapy.

Neuromuscular Basis Of Drosophila Larval Rolling Escape Behavior, Patricia C Cooney, Yuhan Huang, Wenze Li, Dulanjana M Perera, Richard Hormigo, Tanya Tabachnik, Isuru S Godage, Elizabeth M C Hillman, Wesley B Grueber, Aref A Zarin

Faculty, Staff and Student Publications

To escape from dangerous stimuli, animals execute escape behaviors that are fundamentally different from normal locomotion. The rolling escape behavior of Drosophila larvae consists of C-shaped bending and rolling. However, the muscle contraction patterns that lead to rolling are poorly understood. We find that following the initial body bending, muscles contract in a circumferential wave around the larva as they enter the bend, maintaining unidirectional rolling that resembles a cylinder rolling on a surface. We study the structure of motor circuits for rolling, inhibit different motor neurons to determine which muscles are essential for rolling, and propose circuit and biomechanical …

Mgmt Function Determines The Differential Response Of Atr Inhibitors With Dna-Damaging Agents In Glioma Stem Cells For Gbm Therapy, Vincent W S Leong, Sabbir Khan, Pratibha Sharma, Shaofang Wu, Riya R Thomas, Xiaolong Li, Sanjay K Singh, Frederick F Lang, Alfred W K Yung, Dimpy Koul

Faculty, Staff and Student Publications

BACKGROUND: The most prevalent cancer treatments cause cell death through DNA damage. However, DNA damage response (DDR) repair pathways, initiated by tumor cells, can withstand the effects of anticancer drugs, providing justification for combining DDR inhibitors with DNA-damaging anticancer treatments.

METHODS: Cell viability assays were performed with CellTiter-Glo assay. DNA damage was evaluated using Western blotting analysis. RNA-seq and single-cell level expression were used to identify the DDR signatures. In vivo, studies were conducted in mice to determine the effect of ATris on TMZ sensitization.

RESULTS: We found a subpopulation of glioma sphere-forming cells (GSCs) with substantial synergism with temozolomide …

Interleukin-17-Mediated Protective Cytokine Signaling Against Degeneration Of The Retinal Pigment Epithelium, Yan Chen, Sarah E Bounds, Xiang Ma, James Regun Karmoker, Yin Liu, Jian-Xing Ma, Jiyang Cai

Faculty, Staff and Student Publications

Injuries to the retinal pigment epithelium (RPE) and outer retina often result in the accumulation of retinal microglia within the subretinal space. These subretinal microglia play crucial roles in inflammation and resolution, but the mechanisms governing their functions are still largely unknown. Our previous research highlighted the protective functions of choroidal γδ T cells in response to RPE injury. In the current study, we employed single-cell RNA sequencing approach to characterize the profiles of immune cells in mouse choroid. We found that γδ T cells were the primary producer of interleukin-17 (IL-17) in the choroid. IL-17 signaled through its receptor …

Healing Artists Through Art, Corey Aaron Cundiff

Masters Theses

Men die by suicide nearly four times more than women, with higher rates among artists. There has been an increase in the rate of suicide over the years, primarily linked to depression and mounting societal expectations imposed upon men. The prevalence of social media and the awareness that comes with indicates that the issue of suicide may never disappear unless action is taken. This paper examines the need for art therapy to counter depression among male artists. No longer do we need to rely strictly on medication and talk therapy to treat depression. Many art therapy techniques have proven quite …

Conscious Consumers: Understanding The Roles And Impacts Patrons Can Have To Make Ethically Minded Purchases That Affect Society, Mallory Sallstrom

Masters Theses

This thesis will examine the issue that patrons of large corporations are often unaware of how their patronage funds divisive corporate philanthropy resulting in an ethical dilemma for the patron. To better understand this issue, research was conducted through a series of research questions. After completing this research, a literature review was conducted in addition to case studies and visual analyses. Based upon the research, a visual solution was created to serve as a resource and tool to educate consumers about the philanthropic efforts of large corporations as it relates to their values and missions. The thesis visual deliverables include …

Musical Style In Selected Easter Cantatas By John W. Peterson, Youn Song Han

Masters Theses

John W. Peterson is one of the most celebrated American Christian songwriters between 1950s and 1970. He is the best-known for church cantatas such as Christimas, Easter, General, and Choral collections. Peterson's life, music style, and success will be addressed. Next, four Easter cantatas of his cantatas will be analyzed and compared: No Greater Love, The Glory of Easter, Hallelujah for the Cross, and It Took a Miracle. Specifically, there are introduction, his biographical information, historical and musical background in 1950s and 1960s, introduction of four Easter cantatas, analysis of four Easter cantatas, that is, music styles of four Easter …

The Effectiveness Of K-12 Online Music Education During The Covid-19 Lockdown, Christopher Lafser

Doctoral Dissertations and Projects

Despite the successes of online education, students often learn and develop skills in classroom music ensembles that cannot be replicated in online learning. Virtual learning is a new tool for some educators and during the 2020-2022 COVID-19 Pandemic lockdown, many schools were not prepared for the sudden changes the lockdowns needed. Since the lockdown, there have been few studies which examine student music engagement in 100% virtual learning as compared to in-classroom instruction. This qualitative research study examines in what ways music students engage in 100% virtual learning compared to students in a traditional classroom in the areas of musical …