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2023

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Modified Vaccine Vectors To Understand Adjuvant Functions Of Listeria During Chronic Schistosomiasis, Stephanie K. Norwood Oct 2023

Modified Vaccine Vectors To Understand Adjuvant Functions Of Listeria During Chronic Schistosomiasis, Stephanie K. Norwood

Biological Sciences Theses & Dissertations

Vaccination is one of the most effective strategies employed to prevent infectious diseases. Successful vaccination is dependent upon the induction of a specific, robust, and prolonged immune response. One of the major challenges faced by vaccine development is vaccine failure due to host-related factors that can modulate the immune system, which leads to non-responsiveness to vaccinations. The generation of new vaccine strategies is imperative to combat these effects. Live bacterial vectors are one approach used as they can elicit humoral immunity, cellular immunity, or both. Listeria monocytogenes is a Gram positive, intracellular pathogen that is an effective bacterial vaccine vector …

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Dental Hygiene Students Reported Physiological Symptoms Associated With Wearing An N95 Respirator Mask, Peyton Shea Butler Oct 2023

Dental Hygiene Students Reported Physiological Symptoms Associated With Wearing An N95 Respirator Mask, Peyton Shea Butler

Dental Hygiene Theses & Dissertations

Purpose: Physiological symptoms and comfort levels while wearing an N95 respiratory mask has not been examined with dental hygienists. The purpose of this study was to investigate dental hygiene students reported physiological symptoms and comfort perception while wearing an N95 respirator mask during patient care appointments. Methods: After IRB approval (IRB #1987754-2), a 16-item questionnaire was distributed through email to a convenience sample of 65 dental hygiene students. Questions assessed respiratory, dermatologic, cardiac, mask mouth and general physiological symptoms, as well as comfort levels. Additionally, participants were asked to respond to demographic questions and one open ended question inquiring about …

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Diy Handwashing Stations, Mary S. Choate Oct 2023

Diy Handwashing Stations, Mary S. Choate

UNH Cooperative Extension

No abstract provided.

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Agroforestry Woodlot Wanderings October 2023, Ray Berthiaume Oct 2023

Agroforestry Woodlot Wanderings October 2023, Ray Berthiaume

UNH Cooperative Extension

No abstract provided.

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Citizen Science Projects For The Classroom, Malin Clyde, Haley Andreozzi Oct 2023

Citizen Science Projects For The Classroom, Malin Clyde, Haley Andreozzi

UNH Cooperative Extension

No abstract provided.

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Vol 68 #5, Melanie Argo Oct 2023

Vol 68 #5, Melanie Argo

MPLA Newsletter

No abstract provided.

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The Puzzle Of Floating Forum Selection Clauses, Robin J. Effron, John F. Coyle Oct 2023

The Puzzle Of Floating Forum Selection Clauses, Robin J. Effron, John F. Coyle

Faculty Scholarship

No abstract provided.

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A Blunted Th17 Cytokine Signature In Women With Mild Cognitive Impairment: Insights From Inflammatory Profiling Of A Community-Based Cohort Of Older Adults, Adam D. Bachstetter, Jenny Lutshumba, Edric D. Winford, Erin L. Abner, Barbra J. Martin, Jordan P. Harp, Linda J. Van Eldik, Frederick A. Schmitt, Donna M. Wilcock, Ann M. Stowe, Gregory A. Jicha, Barbara S. Nikolajczyk Oct 2023

A Blunted Th17 Cytokine Signature In Women With Mild Cognitive Impairment: Insights From Inflammatory Profiling Of A Community-Based Cohort Of Older Adults, Adam D. Bachstetter, Jenny Lutshumba, Edric D. Winford, Erin L. Abner, Barbra J. Martin, Jordan P. Harp, Linda J. Van Eldik, Frederick A. Schmitt, Donna M. Wilcock, Ann M. Stowe, Gregory A. Jicha, Barbara S. Nikolajczyk

Markey Cancer Center Faculty Publications

People with dementia have an increase in brain inflammation, caused in part by innate and adaptive immune cells. However, it remains unknown whether dementia-associated diseases alter neuro-immune reflex arcs to impact the systemic immune system. We examined peripheral immune cells from a community-based cohort of older adults to test if systemic inflammatory cytokine signatures associated with early stages of cognitive impairment. Human peripheral blood mononuclear cells were cultured with monocyte or T-cell-targeted stimuli, and multiplex assays quantitated cytokines in the conditioned media. Following T-cell-targeted stimulation, cells from women with cognitive impairment produced lower amounts of TH17 cytokines compared with cells …

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Control Of Cd4+ T Cells To Restrain Inflammatory Diseases Via Eukaryotic Elongation Factor 2 Kinase, Hao-Yun Peng, Liqing Wang, Jugal Kishore Das, Anil Kumar, Darby J. Ballard, Yijie Ren, Xiaofeng Xiong, Paul De Figueiredo, Jin-Ming Yang, Jianxun Song Oct 2023

Control Of Cd4+ T Cells To Restrain Inflammatory Diseases Via Eukaryotic Elongation Factor 2 Kinase, Hao-Yun Peng, Liqing Wang, Jugal Kishore Das, Anil Kumar, Darby J. Ballard, Yijie Ren, Xiaofeng Xiong, Paul De Figueiredo, Jin-Ming Yang, Jianxun Song

Markey Cancer Center Faculty Publications

CD4+ T cells, particularly IL-17-secreting helper CD4+ T cells, play a central role in the inflammatory processes underlying autoimmune disorders. Eukaryotic Elongation Factor 2 Kinase (eEF2K) is pivotal in CD8+ T cells and has important implications in vascular dysfunction and inflammation-related diseases such as hypertension. However, its specific immunological role in CD4+ T cell activities and related inflammatory diseases remains elusive. Our investigation has uncovered that the deficiency of eEF2K disrupts the survival and proliferation of CD4+ T cells, impairs their ability to secrete cytokines. Notably, this dysregulation leads to heightened production of pro-inflammatory cytokine IL-17, fosters a pro-inflammatory microenvironment …

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Copy Number Variation That Influences The Ionizing Radiation Sensitivity Of Oral Squamous Cell Carcinoma, Tadahide Izumi, Piotr G. Rychahou, Li Chen, Molly H. Smith, Joseph Valentino Oct 2023

Copy Number Variation That Influences The Ionizing Radiation Sensitivity Of Oral Squamous Cell Carcinoma, Tadahide Izumi, Piotr G. Rychahou, Li Chen, Molly H. Smith, Joseph Valentino

Markey Cancer Center Faculty Publications

Genome instability in cancer cells causes not only point mutations but also structural variations of the genome, including copy number variations (CNVs). It has recently been proposed that CNVs arise in cancer to adapt to a given microenvironment to survive. However, how CNV influences cellular resistance against ionizing radiation remains unknown. PRMT5 (protein arginine methyltransferase 5) and APE1 (apurinic/apyrimidinic endonuclease 1), which enhance repair of DNA double-strand breaks and oxidative DNA damage, are closely localized in the chromosome 14 of the human genome. In this study, the genomics data for the PRMT5 and APE1 genes, including their expression, CNVs, and …

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Dense Granule Protein 3 Of Toxoplasma Gondii Plays A Crucial Role In The Capability Of The Tissue Cysts Of The Parasite To Persist In The Presence Of Anti-Cyst Cd8+ T Cells During The Chronic Stage Of Infection, Rajesh Mani, Mohamed H. Abdelaziz, Eri Ochiai, Qila Sa, Barbara A. Fox, David J. Bzik, Yasuhiro Suzuki Oct 2023

Dense Granule Protein 3 Of Toxoplasma Gondii Plays A Crucial Role In The Capability Of The Tissue Cysts Of The Parasite To Persist In The Presence Of Anti-Cyst Cd8+ T Cells During The Chronic Stage Of Infection, Rajesh Mani, Mohamed H. Abdelaziz, Eri Ochiai, Qila Sa, Barbara A. Fox, David J. Bzik, Yasuhiro Suzuki

Markey Cancer Center Faculty Publications

Toxoplasma gondii establishes chronic infection by forming tissue cysts, and this chronic infection is one of the most common parasitic infections in humans. Our recent studies revealed that whereas CD8 + T cells of genetically resistant BALB/c mice have the capability to remove the tissue cysts of the parasite through their perforin-mediated activities, small portions of the cysts are capable of persisting in the presence of the anti-cyst CD8+ T cells. It is currently unknown how those small portions of the cysts resist or escape the T-cell immunity and persist in the hosts. In the present study, we discovered that …

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Elongation Of Very Long Chain Fatty Acids-3 (Elovl3) Is Activated By Zhx2 And Is A Regulator Of Cell Cycle Progression, Kate Townsend Creasy, Hui Ren, Jieyun Jiang, Martha L. Peterson, Brett T. Spear Oct 2023

Elongation Of Very Long Chain Fatty Acids-3 (Elovl3) Is Activated By Zhx2 And Is A Regulator Of Cell Cycle Progression, Kate Townsend Creasy, Hui Ren, Jieyun Jiang, Martha L. Peterson, Brett T. Spear

Markey Cancer Center Faculty Publications

Zinc fingers and homeoboxes 2 (Zhx2) are transcriptional regulators of liver gene expression with key functions in embryonic development as well as tissue regeneration in response to damage and disease, presumably through its control of target genes. Previous microarray data suggested that elongation of very long chain fatty acids-3 (Elovl3), a member of the ELOVL family of enzymes that synthesize very long chain fatty acids (VLCFAs), is a putative Zhx2 target gene. VLCFAs are core component of ceramides and other bioactive sphingolipids that are often dysregulated in diseases and regulate key cellular processes including proliferation. Since several previously identified Zhx2 …

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Inhibition Of Mitochondrial Fission Activates Glycogen Synthesis To Support Cell Survival In Colon Cancer, Sumati Raj Hasani, Lyndsay E. A. Young, Warren Van Nort, Moumita Banerjee, Dylan R. Rivas, Jinhwan Kim, Xiaopeng Xiong, Ramon C. Sun, Matthew S. Gentry, Hiromi Sesaki, Tianyan Gao Oct 2023

Inhibition Of Mitochondrial Fission Activates Glycogen Synthesis To Support Cell Survival In Colon Cancer, Sumati Raj Hasani, Lyndsay E. A. Young, Warren Van Nort, Moumita Banerjee, Dylan R. Rivas, Jinhwan Kim, Xiaopeng Xiong, Ramon C. Sun, Matthew S. Gentry, Hiromi Sesaki, Tianyan Gao

Markey Cancer Center Faculty Publications

Metabolic reprogramming has been recognized as one of the major mechanisms that fuel tumor initiation and progression. Our previous studies demonstrate that activation of Drp1 promotes fatty acid oxidation and downstream Wnt signaling. Here we investigate the role of Drp1 in regulating glycogen metabolism in colon cancer. Knockdown of Drp1 decreases mitochondrial respiration without increasing glycolysis. Analysis of cellular metabolites reveals that the levels of glucose-6-phosphate, a precursor for glycogenesis, are significantly elevated whereas pyruvate and other TCA cycle metabolites remain unchanged in Drp1 knockdown cells. Additionally, silencing Drp1 activates AMPK to stimulate the expression glycogen synthase 1 (GYS1) mRNA …

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Early Development Of C3ar1-Targeting Chimeric Antigen Receptor T Cells For The Treatment Of Glioblastoma Multiforme, Cameron Fraser Oct 2023

Early Development Of C3ar1-Targeting Chimeric Antigen Receptor T Cells For The Treatment Of Glioblastoma Multiforme, Cameron Fraser

Electronic Theses, Projects, and Dissertations

Glioblastoma multiforme is the most aggressive type of glioma, demonstrating extremely low long-term survival despite modern therapies. Chimeric antigen receptor T cells have shown extreme levels of success in the treatment of B cell lymphomas through persistent anti-tumor activity. Prior research has demonstrated the therapeutic potential in targeting the C3a-C3aR1 pathway as it acts in an autocrine loop, maintaining the proliferation and survival of cancer stem cells within the tumor. Here, we reorient the treatment to target C3aR1 for the treatment of glioblastoma multiforme. In order to achieve this, Jurkat immortalized T cells will express various chimeric antigen receptor designs …

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Corrigendum To “Nigella Sativa As An Antibiotic Alternative To Promote Growth And Enhance Health Of Broilers Challenged With Eimeria Maxima And Clostridium Perfringens” [Poult.Sci.102 (8) (2023) 102831], Vishal Manjunatha, Julian E. Nixon, Greg F. Mathis, Brett S. Lumpkins, Zeynep B. Guzel-Seydim, Atif C. Seydim, Annel E. Greene, Xiuping Jiang Oct 2023

Corrigendum To “Nigella Sativa As An Antibiotic Alternative To Promote Growth And Enhance Health Of Broilers Challenged With Eimeria Maxima And Clostridium Perfringens” [Poult.Sci.102 (8) (2023) 102831], Vishal Manjunatha, Julian E. Nixon, Greg F. Mathis, Brett S. Lumpkins, Zeynep B. Guzel-Seydim, Atif C. Seydim, Annel E. Greene, Xiuping Jiang

Publications

No abstract provided.

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Upscaling Wetland Methane Emissions From The Fluxnet-Ch4 Eddy Covariance Network (Upch4 V1.0): Model Development, Network Assessment, And Budget Comparison, Gavin Mcnicol, Etienne Fluet-Chouinard, Zutao Ouyang, Sara Knox, Zhen Zhang, Tuula Aalto, Sheel Bansal, Kuang Yu Chang, Min Chen, Kyle Delwiche, Sarah Feron, Mathias Goeckede, Jinxun Liu, Avni Malhotra, Joe R. Melton, William Riley, Rodrigo Vargas, Kunxiaojia Yuan, Qing Ying, Qing Zhu, Pavel Alekseychik, Mika Aurela, David Billesbach, David I. Campbell, Jiquan Chen, Housen Chu, Ankur R. Desai, Eugenie Euskirchen, Jordan Goodrich, Timothy Griffis, Manuel Helbig, Takashi Hirano, Hiroki Iwata, Gerald Jurasinski, John King, Franziska Koebsch, Randall Kolka, Ken Krauss, Annalea Lohila, Ivan Mammarella Oct 2023

Upscaling Wetland Methane Emissions From The Fluxnet-Ch4 Eddy Covariance Network (Upch4 V1.0): Model Development, Network Assessment, And Budget Comparison, Gavin Mcnicol, Etienne Fluet-Chouinard, Zutao Ouyang, Sara Knox, Zhen Zhang, Tuula Aalto, Sheel Bansal, Kuang Yu Chang, Min Chen, Kyle Delwiche, Sarah Feron, Mathias Goeckede, Jinxun Liu, Avni Malhotra, Joe R. Melton, William Riley, Rodrigo Vargas, Kunxiaojia Yuan, Qing Ying, Qing Zhu, Pavel Alekseychik, Mika Aurela, David Billesbach, David I. Campbell, Jiquan Chen, Housen Chu, Ankur R. Desai, Eugenie Euskirchen, Jordan Goodrich, Timothy Griffis, Manuel Helbig, Takashi Hirano, Hiroki Iwata, Gerald Jurasinski, John King, Franziska Koebsch, Randall Kolka, Ken Krauss, Annalea Lohila, Ivan Mammarella

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Wetlands are responsible for 20%–31% of global methane (CH4) emissions and account for a large source of uncertainty in the global CH4 budget. Data-driven upscaling of CH4 fluxes from eddy covariance measurements can provide new and independent bottom-up estimates of wetland CH4 emissions. Here, we develop a six-predictor random forest upscaling model (UpCH4), trained on 119 site-years of eddy covariance CH4 flux data from 43 freshwater wetland sites in the FLUXNET-CH4 Community Product. Network patterns in site-level annual means and mean seasonal cycles of CH4 fluxes were reproduced accurately in tundra, boreal, and temperate regions (Nash-Sutcliffe Efficiency ∼0.52–0.63 and 0.53). …

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Overview Of Hypertension In Saudi Arabia: A Systematic Review And Meta-Analysis, Sulaiman A. Alshammari, Abdullah S. Alshammari, Hotoon S. Alshammari, Shaik S. Ahamed Oct 2023

Overview Of Hypertension In Saudi Arabia: A Systematic Review And Meta-Analysis, Sulaiman A. Alshammari, Abdullah S. Alshammari, Hotoon S. Alshammari, Shaik S. Ahamed

Saudi Medical Journal

Objectives: To assess the prevalence, awareness, treatment, and control of hypertension in Saudi Arabia. Methods: We searched electronic databases and the references lists of found publications between 1990 and 2022. Original cross-sectional studies in English were included using PubMed, Google Scholar, and the Saudi Digital Library. A meta-analysis was performed to assess the combined prevalence, awareness, treatment, and control rates of hypertension. Results: Twenty-nine studies with 278873 individuals aged 14-100 were considered. The pooled prevalence of hypertension was 22.66% (95% CI:18.95-26.60), Cochran’s Q=6221.98, dff=22, p <0.0001; I 2 =99.65%, Egger’s test ( p =0.0033) across 23 studies with 272378 people. The pooled hypertension awareness rate was 42.8% from 6 studies with 36046 participants (95% CI:35.66-50.01), Cochran’s Q=781.86, dff=5, p <0.0001; I 2 =99.4% and Egger’s test p =0.3772. The pooled proportion of hypertension patients treated in 6 studies involving 46075 samples was 59.4% (95% CI=38.14-79.02), Cochran’s Q=9793.79 dff=5, p <0.0001; I 2 =99.95%, Egger’s test p =0.8284. The pooled proportion of hypertension-controlled participants across 15 studies comprising 264817 subjects was 34.97% (95% CI: 27.62-42.68), Cochran’s Q=11048.28, dff=14, p <0.0001; I 2 =99.87% and Egger’s test p =0.9760. Conclusion: The prevalence of hypertension was high, with low awareness, treatment, and control rates among Saudis. Therefore, policymakers and healthcare providers must work harmoniously to promote health and to prevent, detect, and control hypertension early. PROSPERO Reg. No.: CRD42023407978

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Iowa Gothic, Caroline Bailey Lewis Oct 2023

Iowa Gothic, Caroline Bailey Lewis

Theses and Dissertations

Iowa Gothic deals with the stories that we tell ourselves, for better or worse, and is an interconnected short story collection set in the fictional town of Madison, Iowa. The stories are grounded in realism, but are also slightly off from the way we typically experience the world: a hoarder who tries to win a cooking contest by boiling a rabbit, a woman who recreates her neighbors' living rooms out of their yard sale items, a hypnotic rooster that starts a feud, residents who believe in ghosts, or at least the communal value of ghost stories. By asking the reader …

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Replenishment Of Essential Natural Resources: An Assessment Of The Ability Of Freshwater Algae To Enhance Crop Quality And Soil Health, Lala Christina Ek Oct 2023

Replenishment Of Essential Natural Resources: An Assessment Of The Ability Of Freshwater Algae To Enhance Crop Quality And Soil Health, Lala Christina Ek

Theses and Dissertations

Disregard for soil, an essential natural resource, hinders global food production. Food insecurity is a major concern for both public health officials and environmental scientists due to soil quality decline, pollution, and climate change. Alternatives or targeted additions to chemical fertilizers can bolster soil quality, improve crop yields, lengthen crop shelf life, and mitigate environmental pollution. One potential alternative to chemical fertilizers is replacement of them with biological soil amendments, including algae, to enhance crop growth and improve soil health. Research was conducted at the University of South Carolina-Columbia campus garden to determine impacts of non-toxic freshwater algae on crop …

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Application Of Computational Tools To Identify Variations Associated With Peromyscus Dominant Spot, Zhenhua Shang Oct 2023

Application Of Computational Tools To Identify Variations Associated With Peromyscus Dominant Spot, Zhenhua Shang

Theses and Dissertations

Peromyscus are the most prevalent mammalian species in North America, and they're employed extensively in both laboratory and field studies. P. maniculatus and P. polionotus, the deer mouse and the old-field mouse, are closely related and can produce viable and fertile hybrid offspring. However, a comprehensive database of polymorphisms, particularly in those kept as living stocks and supplied to university researchers, is lacking. In chapter 2, we performed comparative genomic study on P. maniculatus and P. polionotus and used the polymorphic data to identify the range of genetic complexity that underlies physiological and behavioral differences between two species. We also …

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Antimicrobial Polymers And Small Molecules From Multicyclic Compounds And Engineering Of Sustainable Polymers, Leman Buzoglu Kurnaz Oct 2023

Antimicrobial Polymers And Small Molecules From Multicyclic Compounds And Engineering Of Sustainable Polymers, Leman Buzoglu Kurnaz

Theses and Dissertations

In this dissertation, the synthesis of polymers and small molecules from multicyclic compounds and the development of sustainable polymers from renewable feedstock were investigated. The antimicrobial biomaterials and sustainable polymers were characterized and their properties were discussed. In Chapter 1, the overall background and recent developments of antimicrobial biomaterials and their application were discussed. Later, sustainable polymers from renewable biomass and their synthesis methods were given. Afterward, the main research objectives of this doctoral research study were described. In Chapter 2, the synthesis of multiple charged small molecules from multicyclic compounds was discussed. These compounds were obtained by using various …

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The Effect Of Antibiotics On Immune Cell Infiltration Of Colon In A Mouse Model Of Early Onset Colorectal Cancer, Valerie Hinsch Oct 2023

The Effect Of Antibiotics On Immune Cell Infiltration Of Colon In A Mouse Model Of Early Onset Colorectal Cancer, Valerie Hinsch

Theses and Dissertations

Early onset colorectal cancer (EOCRC) is an aggressive form of colorectal cancer diagnosed before the age of 50. While colorectal cancer cases in patients 50 years and older have been declining, EOCRC cases have been steadily increasing globally in the last few decades, and the cause is unknown. Many agents, called exposomes, have been associated with EOCRC based on their emergence and prevalence prior to and in parallel with the rise in EOCRC cases. Among these are antibiotics (Abx). Abx are indispensable in our fight against infectious diseases, however their overuse is becoming a global epidemic. They are prescribed globally, …

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Progressive Neurochemical, Neuroinflammatory And Cognitive Deficits In An Experimental Model Of Gulf War Illness, Hannah Elizabeth Burzynski Oct 2023

Progressive Neurochemical, Neuroinflammatory And Cognitive Deficits In An Experimental Model Of Gulf War Illness, Hannah Elizabeth Burzynski

Theses and Dissertations

Gulf War Illness (GWI) is a multi-symptom illness that presents with cognitive disturbances and immune dysregulation and continues to affect over 25% of Gulf War veterans. While soldiers were exposed to several hazards in the Gulf, the prophylactic use of the acetylcholinesterase inhibitor, pyridostigmine bromide (PB) and war-related stress have been identified as chief factors in GWI pathology. As both PB and stress alter acetylcholine (ACh), a critical mediator of cognition and inflammation, the focus of my dissertation work was investigating the lasting effects of PB and stress on peripheral and central cholinergic signaling. Specifically, I assessed hippocampal-dependent learning and …

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Effects Of Ai Voice Assistants’ Messages On Pro-Environmnetal Consumer Behavior: Message Content And Voice Attributes, Somang Min Oct 2023

Effects Of Ai Voice Assistants’ Messages On Pro-Environmnetal Consumer Behavior: Message Content And Voice Attributes, Somang Min

Theses and Dissertations

The hospitality and tourism industry has increasingly prioritized environmental concerns, driving the adoption of green practices and communication strategies. This dissertation investigates the role of AI voice assistants in hotel rooms in promoting pro-environmental behavior, recognizing the importance of fostering environmental mindfulness through technology and behavioral interventions. This research explores the influence of voice attributes and message content on consumers' pro-environmental behavior when conveyed through AI voice assistants. It specifically focuses on the marketing cue of Kindchenschema cuteness by examining how a baby-like voice in AI voice assistants may enhance pro-environmental communication, a topic rarely addressed in the hospitality and …

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From Oceans To Public Health: Impact Of Climate Change And Socioecological Factors On Non-Cholera Vibrio Spp., Karlen Enid Correa Vélez Oct 2023

From Oceans To Public Health: Impact Of Climate Change And Socioecological Factors On Non-Cholera Vibrio Spp., Karlen Enid Correa Vélez

Theses and Dissertations

Climate change-induced stressors, such as temperature, salinity, pH, and wildfire, are contributing factors to the increase in frequency of Vibrio infections, altering Vibrio geographical constraints. At the same time, the expansion of the coastal population is resulting in increased input of treated municipal wastewater into areas that are also experiencing Vibrio proliferation. Given that increases in ocean temperature and sea level coupled with increases in human activity in coastal waters support greater Vibrio-human interactions, it is important to examine factors and mechanisms within this socio-ecological coupled system that may further strengthen this interaction. This study aimed to better understand the …

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Revolting Motherhood: [De]Generative Breast Stories Transmuting Medical/Moral Paradigms In Britain During The Long Nineteenth Century, Leslie Rene Pearson Oct 2023

Revolting Motherhood: [De]Generative Breast Stories Transmuting Medical/Moral Paradigms In Britain During The Long Nineteenth Century, Leslie Rene Pearson

Theses and Dissertations

Eric Plemons writes in *The Look of A Woman* that “biological stories do more than describe biologies” (54). This dissertation explores what breast cancer stories do and how society creates meaning around the experience of breast cancer. I argue that, in the long nineteenth century in Britain, breast cancer was part of a two-sided medical/moral paradigm where medical diagnosis became enmeshed with morality. Health, then, became a result of proper domestic behavior, disease a result of straying from societal norms. Following the introductory chapter, chapter two traces the development of this paradigm as an outgrowth of the emergence of middle-class …

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Leveraging Inflammatory Responses Toward Advancing Alzheimer’S Disease Treatments And Biomaterial Implantation, Mihyun Lim Waugh Oct 2023

Leveraging Inflammatory Responses Toward Advancing Alzheimer’S Disease Treatments And Biomaterial Implantation, Mihyun Lim Waugh

Theses and Dissertations

Inflammation is a body’s physiological response to pathogens, foreign materials, or tissue injury. When immune system is triggered, activated leukocytes produce cytokines and chemokines that promote migration of neutrophils and macrophages to the inflammatory regions. At early stages of injury, acute inflammation occurs immediately to fight off the pathogens and restore tissues to homeostasis. However, if the inflammation-inducing stimulus is not removed and thus cells and tissues do not return to its homeostatic state, the prolonged inflammatory responses become a chronic condition. Recent studies have indicated that the receptor for advanced glycation end-products (RAGE), a key receptor of innate immune …

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Broken Bottles: Understanding The Relationship Between Alcohol Outlet Availability And The Proximity To Alcohol Outlets With Binge Drinking Behaviors In College Fraternity Men At Southeastern Public Universities, Jarod Alan Holt Oct 2023

Broken Bottles: Understanding The Relationship Between Alcohol Outlet Availability And The Proximity To Alcohol Outlets With Binge Drinking Behaviors In College Fraternity Men At Southeastern Public Universities, Jarod Alan Holt

Theses and Dissertations

Alcohol use among fraternity affiliated men presents a concerning trend with harmful consequences (DeSimone, 2009; Hingson et al., 2017; McCreary et al., 2021; Nuwer, 2001; Patrick et al., 2022; Ranker & Lipson, 2022). The availability theory of alcohol-related problems suggests alcohol use could be influenced based on the availability and proximity of alcohol outlets in the environment (Dimova, 2023; Kypri et al., 2008; Scribner et al., 2008; Single, 1984; Weitzmann et al., 2003). However, no existing studies of fraternity-affiliated students have examined the relationship of binge drinking and access to alcohol through alcohol outlet availability or proximity. This study examined …

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Structural, Functional And Biochemical Studies To Elucidate The Molecular Basis Of Xenobiotic Metabolism Of Tetranychus Uritcae, A Major Agricultural Pest, Ricardo Hernandez Arriaza Oct 2023

Structural, Functional And Biochemical Studies To Elucidate The Molecular Basis Of Xenobiotic Metabolism Of Tetranychus Uritcae, A Major Agricultural Pest, Ricardo Hernandez Arriaza

Theses and Dissertations

The two-spotted spider mite, Tetranychus urticae, is a major cosmopolitan pest that feeds on more than 1,100 plant species, including 150 crops. Such a wide host range indicates this mite’s unparalleled xenobiotic responsiveness that is also coincident with their ability to rapidly develop resistance to pesticides. An unprecedently large detoxifying machinery is one of the main biological traits responsible for their extraordinary adaptation potential and devastating effect on crops. Availability of the whole genome sequence revealed expansions in all major detoxifying families and demonstrated that this genome has been enriched by horizontally transferred genes from bacteria and fungi. Motivated by …

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The Disappearing Of The Hmong Language, Choua Yang Oct 2023

The Disappearing Of The Hmong Language, Choua Yang

School of Education and Leadership Student Capstone Projects

Within my personal and professional experience, I have observed that the Hmong oral language has declined since the Hmong people arrived in the United States. Over the past 50 years in the United States, there have been growing concerns regarding the decline in usage of the Hmong language within Hmong children. In my personal experience, my children who are second generation Hmong, only the five older children are bilingual while my three younger children only speak English. As for my seven grandchildren, who are third generation Hmong, they only speak English. They do not understand nor speak the Hmong language. …

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