Digital Commons Network^™

Acute Exposure To Two Biocides Causes Morphological And Molecular Changes In The Gill Ciliary Epithelium Of The Invasive Golden Mussel Limnoperna Fortunei (Dunker, 1857), Amanda Maria Siqueira Moreira, Erico Freitas, Mariana De Paula Reis, Júlia Meireles Nogueira, Newton Pimentel De Ulhôa Barbosa, André Luiz Martins Reis, Afonso Pelli, Paulo Ricardo Da Silva Camargo, Antonio Valadão Cardoso, Rayan Silva De Paula, Erika Cristina Jorge

Michigan Tech Publications

Limnoperna fortunei, the golden mussel, is a bivalve mollusk considered an invader in South America. This species is responsible for ecological and economic damages due to its voluminous fouling capability. Chemical biocides such as MXD-100™ and sodium dichloroisocyanurate (NaDCC) are often used to control L. fortunei infestations in hydraulic systems. Thus, we proposed to investigate the effects of different periods (24, 48 and 72 h) of exposure to MXD-100™ (0.56 mg L−1) and NaDCC (1.5 mg L−1) on the gills of L. fortunei through morphological and molecular analyses. NaDCC promoted progressive morphological changes during the analyzed periods and only an …

Adaptive Design Of Mrna-Loaded Extracellular Vesicles For Targeted Immunotherapy Of Cancer, Shiyan Dong, Xuan Liu, Ye Bi, Yifan Wang, Abin Antony, Daeyong Lee, Kristin Huntoon, Seongdong Jeong, Yifan Ma, Xuefeng Li, Weiye Deng, Benjamin R Schrank, Adam J Grippin, Jonghoon Ha, Minjeong Kang, Mengyu Chang, Yarong Zhao, Rongze Sun, Xiangshi Sun, Jie Yang, Jiayi Chen, Sarah K Tang, L James Lee, Andrew S Lee, Lirong Teng, Shengnian Wang, Lesheng Teng, Betty Y S Kim, Zhaogang Yang, Wen Jiang

Faculty, Staff and Student Publications

The recent success of mRNA therapeutics against pathogenic infections has increased interest in their use for other human diseases including cancer. However, the precise delivery of the genetic cargo to cells and tissues of interest remains challenging. Here, we show an adaptive strategy that enables the docking of different targeting ligands onto the surface of mRNA-loaded small extracellular vesicles (sEVs). This is achieved by using a microfluidic electroporation approach in which a combination of nano- and milli-second pulses produces large amounts of IFN-γ mRNA-loaded sEVs with CD64 overexpressed on their surface. The CD64 molecule serves as an adaptor to dock …

Tumultuous Devotions: Female Entrapment & Empowerment In The Lais Of Marie De France, Trent Dunkin

Tête à Tête: Journal of Francophone Studies

No abstract provided.

Historical Inquiry Deliberation (Hid): The New Republic Lesson Plan, Rhonda Kemp Webb

Teaching Social Studies in the Peach State

The following lesson plan is an example of adapting the Structured Academic Controversy (SAC) format for engaging students in the deliberation of the multiple perspectives for a current societal issue to instead create a procedure for evaluating a historical event or decision. The sample lesson included here for engaging students in this process is entitled “Historical Inquiry Deliberation: The New Republic” and requires students to deliberate the following question:

Which of the competing visions for America’s future was the best approach for the nation at the early stage of its development in the late 18^th century?

• Manufacturing: The US …

Mitochondrial Transplantation And Transfer: The Promising Method For Diseases, Gökhan Burçi̇n Kubat

Turkish Journal of Biology

Mitochondria are organelles that serve as the powerhouses for cellular bioenergetics in eukaryotic cells. It is responsible for mitochondrial adenosine triphosphate (ATP) generation, cell signaling and activity, calcium balance, cell survival, proliferation, apoptosis, and autophagy. Mitochondrial transplantation is a promising disease therapy that involves the recovery of mitochondrial dysfunction using isolated functioning mitochondria. The objective of the present article is to provide current knowledge on natural mitochondrial transfer processes, in vitro and in vivo applications of mitochondrial transplantation, clinical trials, and challenges associated with mitochondrial transplantation.

Criminalization Of Environmental Harms In Bangladesh And The United States, Md Lokman Hussain

Theses and Dissertations

This study explores and compares the nature, features, and measures of criminalization of environmental harms in Bangladesh and United States. The exploration is based on the descriptive and analytical comparison of the legal frameworks addressing the environmental harms in these two countries. To explore how are environmental harms criminalized in Bangladesh and United States, following aspects were described and compared: the criminalizing power of the state, criminalization of environmental harms regarding air pollution, water pollution, protection of biodiversity, waste management, and use of pesticide, theoretical frameworks in explaining criminalization, role of constitution and international law.

Law And Its Limits: Ethical Issues In Mary Shelley’S Frankenstein Or, The Modern Prometheus, David S. Caudill

St. Mary's Journal on Legal Malpractice & Ethics

The law and literature movement is frequently associated with the use of literary images of law as a point of reflection upon the ethical obligations of lawyers. Mary Shelley’s Frankenstein (1818)—the story of a young scientist whose unorthodox experiments end up creating the famed “monster”—is not, at first glance, a likely candidate for that enterprise. However, Dr. Frankenstein’s ambition and ruthless pursuit of knowledge has become a contemporary image of science out of control and the need for ethical limitations on scientific progress. Consequently, the novel raises currently important issues of regulating science and technology. Given the lawyer’s ethical obligation …

The Bg News October 18, 2023, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. October 18, 2023. Volume 103-Issue 08.

The Lumberjack, October 18, 2023

Cal Poly Humboldt's Student Newspaper

The student newspaper of Humboldt State University.

The Association Of Research Quantitative Measures With Faculty Ranks Of Australian And New Zealand Dental Schools, Ayesha Fahim, Sadia Shakeel, Farhan Saleem, Ijaz Ur Rehman, Kashif Siddique, Habib Ahmad Qureshi, Muhammad Sohail Zafar

Research outputs 2022 to 2026

Introduction: The scholarly productivity of a faculty member can be measured through several indicators including annual appraisals, feedback, and the number of publications per year. The present study aims to assess the association of quantitative research measures and academic ranks in Australian and New Zealand dental schools. Methods: It was an analytical observational cross-sectional study. Full-time faculty members working in Australia and New Zealand's dental schools were discovered on official websites. Various bibliometric parameters including h-index, total number of citations, total number of publications, and maximum number of sources of a single publication were analyzed. Spearman rank correlation was used …

Lrtransformer: Learn-Region Transformer For Object-Agnostic Point Cloud Segmentation, Dipesh Gyawali

LSU Master's Theses

3D point cloud segmentation segments the 3D point cloud data into different regions/instances depending on their features that have numerous applications in robotics, autonomous driving, digital twinning, augmented reality, etc. The majority of the existing point cloud segmentation methods depend on class labels to identify 3D objects in the surroundings. Our work focuses on segmenting point clouds into different regions/instances in an object-agnostic manner for any number of objects in the environment. Given the point cloud, our method can segment the entire scene into multiple instances without depending on object shape and size. We leverage the power of the self-attention …

Flexibility For Intensity Dosing In Lingual Resistance Exercises: A Large Randomized Clinical Trial In Typically Aging Adults As Proof Of Principle, Sarah Szynkiewicz, Teresa Drulia, Lindsay Griffin, Rachel Mulheren, Kelsey Murray, Theresa Lee, Erin Kamarunas

Department of Communication Sciences and Disorders - Faculty Scholarship

Objective: The objective of this study was to determine the effect of intensity dosing during tongue exercise on tongue pressure generation, adherence, and perceived effort.

Design: This was a five-site, prospective, randomized clinical trial. Outcome measures were obtained across multiple baselines, biweekly during exercise, and 4-weeks post-intervention.

Setting: The general community at each study site. Participants: Typically aging adults between 55–82 years of age with no history of neurological or swallowing disorders. Eighty-four volunteers completed the study.

Interventions: Participants were randomly assigned to one of four exercise groups: (a) maximum intensity/no biofeedback, (b) progressive intensity/no bio- feedback, (c) maximum intensity/biofeedback, …

Aim110.1 23t3 Project Documentation Exemplar B Example 1, Sae University College

Exemplars

AIM110.1 23T3 Project Documentation Exemplar B

Ribosomal Protein L8 Regulates The Expression And Splicing Pattern Of Genes Associated With Cancer-Related Pathways, Leilei Xu, Gui Yang, Bin Song, Dong Chen, Akbar. Yunus, Jiangtao Chen, Xiaogang Yang, Zheng Tian

Turkish Journal of Biology

Background/aim: Ribosomal proteins have been shown to perform unique extraribosomal functions in cell apoptosis and other biological processes. Ribosomal protein L8 (RPL8) not only has important nonribosomal regulatory functions but also participates in the oncogenesis and development of tumors. However, the specific biological functions and pathways involved in this process are still unknown. Materials and methods: RPL8 was overexpressed (RPL8-OE) in HeLa cells. MTT assay and flow cytometry were used to detect cell proliferation and apoptosis, respectively. Transcriptome sequencing was performed to analyze the differentially expressed genes (DEGs) and regulated alternative splicing events (RASEs) by RPL8-OE, both of which were …

Polar Oceans And Sea Ice In A Changing Climate, Megan D. Willis, Delphine Lannuzel, Brent Else, Hélène Angot, Karley Campbell, Odile Crabeck, Bruno Delille, Hakase Hayashida, Martine Lizotte, Brice Loose, Klaus M. Meiners, Lisa Miller, Sebastien Moreau, Daiki Nomura, John Prytherch, Julia Schmale, Nadja Steiner, Letizia Tedesco, Jennie Thomas

Graduate School of Oceanography Faculty Publications

Polar oceans and sea ice cover 15% of the Earth’s ocean surface, and the environment is changing rapidly at both poles. Improving knowledge on the interactions between the atmospheric and oceanic realms in the polar regions, a Surface Ocean-Lower Atmosphere Study (SOLAS) project key focus, is essential to understanding the Earth system in the context of climate change. However, our ability to monitor the pace and magnitude of changes in the polar regions and evaluate their impacts for the rest of the globe is limited by both remoteness and sea-ice coverage. Sea ice not only supports biological activity and mediates …

2023-10-18 Ahoy! Nintendo & The Seattle Aquarium Partner To Bring “New Horizons” To Life, Leila Bunker

The Spectator Online

No abstract provided.

Gooseberry Anthocyanins Alleviate Insulin Resistance By Regulating Ceramide Metabolism In High Fat Diet Mice, Xian Tang, Jun Gao, Jinpeng Huang, Chenjuan Zhang, Hongwei Liu, Jie Wei

Turkish Journal of Biology

Background/aim: Obesity is the fifth largest risk factor of death in the world. The ceramide produced by obesity is closely related to insulin resistance (IR) caused by obesity. At present, the commercially available weight loss products have large side effects and limited therapeutic effects. Therefore, it is particularly important to find effective natural nontoxic products to treat obesity and explore its possible pathways and mechanisms. Materials and methods: In this paper, a high-fat diet (HFD) mice model was established by intragastric administration of high-fat emulsion to investigate the intervention effect of Gooseberry anthocyanins (GA) on IR in HFD mice. We …

Law And Its Limits: Ethical Issues In Mary Shelly's Frankenstein Or, The Modern Prometheus, David S. Caudill

Faculty Publications

The law and literature movement is frequently associated with the use of literary images of law as a point of reflection upon the ethical obligations of lawyers. Mary Shelley’s Frankenstein (1818)—the story of a young scientist whose unorthodox experiments end up creating the famed “monster”—is not, at first glance, a likely candidate for that enterprise. However, Dr. Frankenstein’s ambition and ruthless pursuit of knowledge has become a contemporary image of science out of control and the need for ethical limitations on scientific progress. Consequently, the novel raises currently important issues of regulating science and technology. Given the lawyer’s ethical obligation …

Reprogramming Of Cis-Regulatory Networks During Skeletal Muscle Atrophy In Male Mice, Hongchun Lin, Hui Peng, Yuxiang Sun, Meijun Si, Jiao Wu, Yanlin Wang, Sandhya S Thomas, Zheng Sun, Zhaoyong Hu

Faculty, Staff and Students Publications

A comprehensive atlas of cis-regulatory elements and their dynamic activity is necessary to understand the transcriptional basis of cellular structure maintenance, metabolism, and responses to the environment. Here we show, using matched single-nucleus chromatin accessibility and RNA-sequencing from juvenile male C57BL6 mice, an atlas of accessible chromatin regions in both normal and denervated skeletal muscles. We identified cell-type-specific cis-regulatory networks, highlighting the dynamic regulatory circuits mediating transitions between myonuclear types. Through comparison of normal and perturbed muscle, we delineated the reprogramming of cis-regulatory networks in response to denervation, described the interplay of promoters/enhancers and target genes. We further unveil a …

Braf D594a Mutation Defines A Unique Biological And Immuno-Modulatory Subgroup Associated With Functional Cd8+ T Cell Infiltration In Colorectal Cancer, Wenjing Li, Chenyi Zhao, Wenhui Li, Yang Gong, Kaili Ma, Yujie Lu, Xiaowei Liu, Lianjun Zhang, Feng Guo

Faculty, Staff and Student Publications

BACKGROUND: BRAF non-V600 mutation occupies a relatively small but critical subset in colorectal cancer (CRC). However, little is known about the biological functions and impacts of BRAF class III mutation in CRC. Here, we aim to explore how D594A mutation impacts on biological behaviors and immune related signatures in murine CRC cells.

METHODS: BRAF V600E (class I), G469V (class II) and D594A (class III) mutant cell lines were established based on MC38 cells. The biological behaviors of cells were evaluated in respect of cell growth, cell proliferation, cell apoptosis, cell migration and invasion by the methods of colony-forming assay, CCK-8 …

Biomechanical Origins Of Proprioceptor Feature Selectivity And Topographic Maps In The Drosophila Leg, Akira Mamiya, Anne Sustar, Igor Siwanowicz, Yanyan Qi, Tzu-Chiao Lu, Pralaksha Gurung, Chenghao Chen, Jasper S Phelps, Aaron T Kuan, Alexandra Pacureanu, Wei-Chung Allen Lee, Hongjie Li, Natasha Mhatre, John C Tuthill

Faculty, Staff and Students Publications

Our ability to sense and move our bodies relies on proprioceptors, sensory neurons that detect mechanical forces within the body. Different subtypes of proprioceptors detect different kinematic features, such as joint position, movement, and vibration, but the mechanisms that underlie proprioceptor feature selectivity remain poorly understood. Using single-nucleus RNA sequencing (RNA-seq), we found that proprioceptor subtypes in the Drosophila leg lack differential expression of mechanosensitive ion channels. However, anatomical reconstruction of the proprioceptors and connected tendons revealed major biomechanical differences between subtypes. We built a model of the proprioceptors and tendons that identified a biomechanical mechanism for joint angle selectivity …

A Fairness Assessment Of Mobility-Based Covid-19 Case Prediction Models, Abdolmajid Erfani, Vanessa Frias-Martinez

Michigan Tech Publications

In light of the outbreak of COVID-19, analyzing and measuring human mobility has become increasingly important. A wide range of studies have explored spatiotemporal trends over time, examined associations with other variables, evaluated non-pharmacologic interventions (NPIs), and predicted or simulated COVID-19 spread using mobility data. Despite the benefits of publicly available mobility data, a key question remains unanswered: are models using mobility data performing equitably across demographic groups? We hypothesize that bias in the mobility data used to train the predictive models might lead to unfairly less accurate predictions for certain demographic groups. To test our hypothesis, we applied two …

Queering Ecology: Three Investigations From Indigenous Women In Post-Conflict North Sumatra, Perdana Roswaldy

Antropologi Indonesia

Feminists and environmental scholars draw connections between gender inequality, heterosexism, and the devastating impact of environmental catastrophes on the livelihoods of women and gender minorities, exacerbating their precarity. This body of scholarship has begun to imagine alternatives to patriarchal gender and heterosexual norms for reconciling the relationship between humans and nature by calling for "queer(ing) ecology." I investigate the possibility of queering ecology by posing three theoretical concerns in opposition to anthropocentric and gendered preconceptions about nature: its idleness, naturality, and rightfulness. Respectively, I will dissect such presumptions by questioning nature as metaphors, investigating "the natural" attribute in nature, and …

The Green Encounters: “Common Good” Narrative And Community Struggle In Halimun Salak Coridor, West Java, Sulastri Sardjo

Antropologi Indonesia

Since the colonial era of the East Indies, multiple ruling regimes have promoted a certain narrative to utilize the forests on Mount Halimun Salak for nature preservation and profit accumulation. Existing studies of the designation of Halimun Salak as a conservation area have shown that such an establishment led to conflicts over land and livelihoods with the surrounding communities and local farmers. Complementing these studies, my qualitative research in the Halimun Salak Corridor (HSC) highlights that the “common good” narrative promoted by conservation programs has not benefited people’s livelihoods. Conversely, the expansion of conservation area through HSC has further restricted …

The Elevated Station Of Chauntecleer: The Great Chain Of Being And Augustinian Sign Theory In 'The Nun's Priest's Tale', Lara Rudman '25

Furman Humanities Review

No abstract provided.

Ptsd Detection Device, Jason Yager, Grace Schmidt, Daniel Torsney, Tanner Van Newkirk, Jonathan Montgomery, Ming Huang

Creative Collaborations: Annual Showcase of Undergraduate Research

This project focuses on improving the well being and independence of veterans struggling with Post Traumatic Stress Disorder (PTSD). Service dogs are vital for a veteran in daily routines and for emotional support. They are trained to prevent their veteran from experiencing a PTSD episode, but the service dog could be preoccupied with another task or in an environment that makes it difficult for them to read their veteran. To fix this issue, we have developed a device for the veteran and a device for the service dog. The veteran's device is wearable and will be able to track important …

Of Revolution Or Postcoloniality? Identity Practices Of Algerian Immigrants And Their Descendants In France, Elizabeth Nelson

The Geographical Bulletin

Using qualitative research techniques, this article demonstrates how colonial memory and postcolonial dynamics permeate the everyday lives and encounters of Algerian-origin people in France and inform the ways they conceive of, and experience, social membership and belonging. This work investigates what it means to be a racialized minority in a postcolonial context and to learn and experience the boundaries of ‘Frenchness’ and ‘Algerianness.’ It is based on the narratives of Algerian immigrants who have migrated to Paris, France and their French-born children. The empirical evidence highlights how Algerian immigrants and their descendants encounter and structure their interactions with French society. …

Data Sharing And Ontology Use Among Agricultural Genetics, Genomics, And Breeding Databases And Resources Of The Agbiodata Consortium, Jennifer L. Clarke, Laurel D. Cooper, Monica F. Poelchau, Tanya Z. Berardini, Justin Elser, Andrew D. Farmer, Stephen Ficklin, Sunita Kumari, Marie-Angélique Laporte, Rex T. Nelson, Rie Sadohara, Peter Selby, Anne E. Thessen, Brandon Whitehead, Taner Z. Sen

Department of Statistics: Faculty Publications

Over the last couple of decades, there has been a rapid growth in the number and scope of agricultural genetics, genomics and breeding databases and resources. The AgBioData Consortium (https://www.agbiodata.org/) currently represents 44 databases and resources (https://www.agbiodata.org/databases) covering model or crop plant and animal GGB data, ontologies, pathways, genetic variation and breeding platforms (referred to as ‘databases’ throughout). One of the goals of the Consortium is to facilitate FAIR (Findable, Accessible, Interoperable, and Reusable) data management and the integration of datasets which requires data sharing, along with structured vocabularies and/or ontologies. Two AgBioData working groups, focused on Data Sharing and …

Spartan Daily, October 17, 2023, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2023

Volume 161, Issue 24

A Scoping Review Of Nutrition Health For Older Adults: Does Technology Help?, Dara L. Lobuono, Michael Milovich Jr.

Rita & Larry Salva School of Nursing and Health Professions Departmental Research

The technological developments in healthcare may help facilitate older adult nutritional care. This scoping review includes research in technology and nutrition to (1) explain how technology is used to manage nutrition needs and (2) describe the forms of technology used to manage nutrition. Five major databases were the foundation for papers published from January 2000 to December 2020. The most common type of technology used is software to (1) “track, plan, and execute” nutrition management and for (2) “assessing” technology use. “Track, plan, and execute” includes tracking food intake, planning for changes, and executing a plan. “Assessing” technology use is …