Digital Commons Network^™

The Impact Of Vaccine-Linked Chemotherapy On Liver Health In A Mouse Model Of Chronic Trypanosoma Cruzi Infection, Duc Minh Nguyen, Cristina Poveda, Jeroen Pollet, Fabian Gusovsky, Maria Elena Bottazzi, Peter J Hotez, Kathryn Marie Jones

Faculty, Staff and Students Publications

BACKGROUND: Chagas disease, chronic infection with Trypanosoma cruzi, mainly manifests as cardiac disease. However, the liver is important for both controlling parasite burdens and metabolizing drugs. Notably, high doses of anti-parasitic drug benznidazole (BNZ) causes liver damage. We previously showed that combining low dose BNZ with a prototype therapeutic vaccine is a dose sparing strategy that effectively reduced T. cruzi induced cardiac damage. However, the impact of this treatment on liver health is unknown. Therefore, we evaluated several markers of liver health after treatment with low dose BNZ plus the vaccine therapy in comparison to a curative dose of BNZ. …

Preterm Pigs Fed Donor Human Milk Have Greater Liver Β-Carotene Concentrations Than Pigs Fed Infant Formula, Nancy E Moran, Joshua Wade, Rachel Stroh, Barbara Stoll, Gregory Guthrie, Amy B Hair, Douglas G Burrin

Faculty, Staff and Students Publications

BACKGROUND: Milk carotenoids may support preterm infant health and neurodevelopment. Infants fed human milk often have higher blood and tissue carotenoid concentrations than infants fed carotenoid-containing infant formula (IF). Donor human milk (DHM) is a supplement to mother's own milk, used to support preterm infant nutrition.

OBJECTIVES: We tested whether tissue and plasma β-carotene concentrations would be higher in preterm pigs fed pasteurized DHM versus premature IF.

METHODS: This is a secondary analysis of samples collected from a study of the effects of enteral diet composition on necrotizing enterocolitis incidence. Preterm pigs received partial enteral feeding of either DHM (n …

Characterizing The Impact Of Enterococcus Cecorum Infection During Late Embryogenesis On Disease Progression, Cecal Microbiome Composition, And Early Performance In Broiler Chickens, Marcela Arango, Aaron Forga, Jing Liu, Latasha Gray, Randy Moore, Makenly E. Coles, Abdiel Atencio, Carolina Trujillo, Juan David Latorre, Guillermo Tellez-Isaias, Billy Hargis, Danielle Graham

Poultry Science Faculty Publications and Presentations

Enterococcus cecorum (EC) has been associated with septicemia and early mortality in broiler chickens. There is limited research investigating the pathogenicity of EC field strains obtained from affected birds. The purpose of this study was to evaluate the effect of in-ovo administration into the amnion with different EC field isolates at d 18 of embryogenesis (DOE18). In Exp 1, 7 EC field isolates alone or in combination (EC1–EC3, EC4–EC5, EC6, and EC7) were selected based on phenotypic characteristics and evaluated at different concentrations (1 × 10², 1 × 10⁴, and 1 × …

Evaluation Of Rotenone Mediated Α-Synuclein Spreading And Neurotoxicity In Intra-Striatal Injection Of Α-Synuclein Pff Model Of Parkinson’S Disease, Engila Khan

Theses

In the last 25 years, the prevalence of Parkinson’s Disease (PD) across the globe has doubled. Clinical manifestations of this progressive neurodegenerative disorder include motor symptoms such as tremors, bradykinesia, postural instability, etc., which occur due to selective loss of dopaminergic neurons in the Substantia nigra (SNC) in the brain. The histopathological feature of PD is the presence of intra-neuronal aggregates of proteins called Lewy bodies, a major constituent of which is α-synuclein (α-syn).

Epidemiological studies to date have reported a connection between exposure to environmental neurotoxins such as Rotenone (a mitochondrial complex 1 inhibitor) and increased risk of PD …

Population Structure And Genetic Diversity Of The Socotra Cormorant (Phalacrocorax Nigrogularis), Noura Mabkhout Almansoori

Theses

The Socotra cormorants (Phalacrocorax nigrogularis) are regional endemic seabirds restricted to the Arabian Gulf, Gulf of Oman, and the Arabian Sea. This species is classified as vulnerable by the IUCN Red List. However, no population genetic study has been conducted on P. nigrogularis in their range, and population structure, gene flow and connectivity between colonies is unknown. Likewise, genetic diversity of this species has not yet been characterized. Thus, the aim of this thesis was to fill these gaps by inferring population structure, assessing gene flow and genetic diversity of Socotra cormorant colonies in their known distribution range. …

Anti Cancer Activity Of Rhus Coriaria (Sumac) Against 5-Fluorouracil-Resistant Colorectal Cancer Cells, Zohra Nausheen Nizami

Theses

Colorectal cancer (CRC) is the second leading cause of cancer-related deaths, both worldwide and in the UAE. 5-Fluorouracil (5-FU), a pyrimidine analogue, is a chemotherapeutic agent that is an integral component of chemotherapy regimens for CRC treatment. However, 5-FU resistance (intrinsic and/or acquired) inhibits their clinical efficacy. In recent years, there has been a growing popularity for plant-based cancer therapeutics, specifically using phytochemical compounds. Rhus coriaria (Sumac) is a Mediterranean plant whose fruits are used as a spice and medicinal herb. Extracts of Rhus coriaria fruits (RCE) have been reported to exhibit anti-cancer activity against breast cancer and CRC. In …

The Association Between Total And Types Of Dietary Protein Intake And Prevelence Of Impaired Fasting Glucose And Type 2 Diabetes, Afra Salah Alsammach

Theses

People with impaired fasting glucose (IFG) and type 2 diabetes (T2D) need to modify their dietary composition. This could assist in the management and prevention of the disease. However, the role played by the composition of specific dietary macronutrients on the risk of IFG & T2D needs further research. This study sought to examine the association between total and type of dietary protein (animal and plant) consumption with prevalence of T2D and IFG. Aims: To investigate the association between total intake and types (animal vs plant) of dietary protein intake and prevalence of IFG & T2D in adults. Data …

Modification Of Cellulose Fibers By Acyl Grafting For Oil Spill Remediation, Fatima Saif Alhumaidi

Theses

Oil spills represent a significant source of aquatic pollution with substantial repercussions on the environment as well as the economic and societal well-being of coastal communities. This research project is focused on the utilization of chemically modified cellulose-based fibers to remediate oil-contaminated water. The hydroxyl groups present in cellulose were acetylated under optimized conditions, thereby rendering the fibers hydrophobic and enhancing their affinity for crude oil. The modified cellulosic material was characterized by several physical and chemical techniques (IR, TGA, contact angle measurement, SEM, and back titration) to determine the extent of acylation and assess their morphological properties. The derivatized …

Constructing Holistic Spatio-Temporal Scene Graph For Video Semantic Role Labeling, Yu Zhao, Hao Fei, Yixin Cao, Bobo Li, Meishan Zhang, Jianguo Wei, Min Zhang, Tat-Seng Chua

Research Collection School Of Computing and Information Systems

As one of the core video semantic understanding tasks, Video Semantic Role Labeling (VidSRL) aims to detect the salient events from given videos, by recognizing the predict-argument event structures and the interrelationships between events. While recent endeavors have put forth methods for VidSRL, they can be mostly subject to two key drawbacks, including the lack of fine-grained spatial scene perception and the insufficiently modeling of video temporality. Towards this end, this work explores a novel holistic spatio-temporal scene graph (namely HostSG) representation based on the existing dynamic scene graph structures, which well model both the fine-grained spatial semantics and temporal …

Npf-200: A Multi-Modal Eye Fixation Dataset And Method For Non-Photorealistic Videos, Ziyu Yang, Sucheng Ren, Zongwei Wu, Nanxuan Zhao, Junle Wang, Jing Qin, Shengfeng He

Research Collection School Of Computing and Information Systems

Non-photorealistic videos are in demand with the wave of the metaverse, but lack of sufficient research studies. This work aims to take a step forward to understand how humans perceive nonphotorealistic videos with eye fixation (i.e., saliency detection), which is critical for enhancing media production, artistic design, and game user experience. To fill in the gap of missing a suitable dataset for this research line, we present NPF-200, the first largescale multi-modal dataset of purely non-photorealistic videos with eye fixations. Our dataset has three characteristics: 1) it contains soundtracks that are essential according to vision and psychological studies; 2) it …

Followupqg: Towards Information-Seeking Follow-Up Question Generation, Yan Meng, Liangming Pan, Yixin Cao, Min-Yen Kan

Research Collection School Of Computing and Information Systems

Humans ask follow-up questions driven by curiosity, which reflects a creative human cognitive process. We introduce the task of realworld information-seeking follow-up question generation (FQG), which aims to generate follow-up questions seeking a more in-depth understanding of an initial question and answer. We construct FOLLOWUPQG, a dataset1 of over 3K real-world (initial question, answer, follow-up question) tuples collected from a Reddit forum providing layman-friendly explanations for open-ended questions. In contrast to existing datasets, questions in FOLLOWUPQG use more diverse pragmatic strategies to seek information, and they also show higher-order cognitive skills (such as applying and relating). We evaluate current question …

Laf: Labeling-Free Model Selection For Automated Deep Neural Network Reusing, Qiang Hu, Yuejun Guo, Xiaofei Xie, Maxime Cordy, Mike Papadakis, Yves Le Traon

Research Collection School Of Computing and Information Systems

pplying deep learning (DL) to science is a new trend in recent years, which leads DL engineering to become an important problem. Although training data preparation, model architecture design, and model training are the normal processes to build DL models, all of them are complex and costly. Therefore, reusing the open-sourced pre-trained model is a practical way to bypass this hurdle for developers. Given a specific task, developers can collect massive pre-trained deep neural networks from public sources for reusing. However, testing the performance (e.g., accuracy and robustness) of multiple deep neural networks (DNNs) and recommending which model should be …

Ai Application In Architecture In Uae: Developing And Testing Advanced Optimization Model For A Parametric Shading Structure As A Retrofit Strategy Of A Midrise Residential Building Façade In Downtown Abu Dhabi, Anwar Ghaleb Ahmad

Theses

Artificial intelligence is a phenomenon that influences every aspect of our lives. AI applications have already started to change the methods in different disciplines. Architecture is one of the disciplines that is highly affected by the developments of AI technologies. With the United Arab Emirates heading to employ new technology to lead the country and region development, it is important to explore and develop the application of AI in the strategic disciplines of the country in which the built environment is essential. This study aimed to develop and evaluate an advanced model script (to be used as a tool) using …

Canagliflozin Ameliorates Autistic-Like Features And Mitigates Brain Oxidative Stress Levels In Valproic Acid-Induced Autism In Rats, Mohammad Moutaz Nakhal

Theses

Autism spectrum disorder (ASD) is a neurodevelopmental disease with a substantially increasing incidence rate. It is mainly characterized by repetitive behavior, intellectual difficulties, social communication and interactions deficits. Many medications, dietary supplements, and behavioral treatments have been recommended for ASD management, however, there is no cure yet. Recent studies have examined the therapeutic potential of the sodium-glucose cotransporter 2 (SGLT2) inhibitors in neurodevelopmental diseases, based on their proved anti-inflammatory and antioxidant effects. The main objective of this study is to assess the ability of canagliflozin in improving the behavioural characteristics of autistic rats and investigate the efficacy of canagliflozin in …

Investigating Bim Applications In Reducing Co2 Emissions In The Built Environment – Uae Context, Rua Ahmed Maali

Theses

Large amounts of CO₂ are released into the atmosphere throughout the life cycle of a building starting from the production of materials and products, in the construction phase of the building itself, in the site setting, the renovations, the later rehabilitation, and up to the final demolition. Hence, this thesis aims to investigate the potential of using Building Information Modeling (BIM) in making informed decisions that can help in reducing CO₂ emissions in the life cycle of built environment projects. This study has used a mixed method approach that includes literature review, a case study and semistructured interviews. …

Selection Of Natural Surfactants For Possible Use In Improving Oil Recovery Of Carbonate Oil Reservoirs, Hiba Hachem Limam

Theses

Middle East petroleum industry is currently searching for the most suitable enhanced oil technique to improve the oil recovery from local oil reservoirs. The biggest challenge for the application of enhanced oil recovery (EOR) in the Middle East is the harsh environment (high salinity and temperature). Surfactant (synthetic or natural) is one of the EOR major players considered for application in the Middle East. However, synthetic surfactants have several drawbacks, such as economically unattractive and environmental impacts. This study investigated the possible use of natural surfactant extracted from the leaves of three types of plants, namely Aloe Vera, Tetraena qatarensis, …

The Association Between Added Sugar And Abdominal Obesity In Adults, Noora Salem Alhammadi

Theses

Excessive body fat accumulation is a complicated medical condition known as obesity. Obesity increases the risk of chronic diseases including type 2 diabetes mellitus, cardiovascular disease, and several types of cancer. Numerous studies have shown that adults who regularly consume added sugar, mostly from sugar sweetened beverages, are more likely to be overweight or obese and/or abdominal obesity, however results remain controversial. The primary objective was to evaluate the relationship between Greek adults’ consumption of added sugar and abdominal obesity. The primary outcome was to investigate the intakes of added sugars in relation to weight status, fat mass, and specific …

Effects Of Adropin On Metabolic Parameters, Oxidative Stress, And Cell Proliferation In Animal Model Of Diabetes Mellitus, Ifrah Ismail Ali

Dissertations

Diabetes Mellitus (DM) is a major health condition that has reached alarming levels, affecting around 537 million of the global adult population. DM is a group of metabolic diseases characterized by hyperglycemia with disturbance in carbohydrate, fat, and protein metabolism. The proposed therapeutic options for DM are different according to their mechanism of action, and peptide therapy is one of these options. Adropin, a peptide hormone involved in energy homeostasis, has shown promising results in the treatment of diabetes by lowering fasting blood glucose, reducing insulin resistance, and minimizing fat storage. Moreover, it has been demonstrated that adropin is engaged …

Biosecurity Council Of Western Australia Annual Report 2022/2023, Biosecurity Council Of Western Australia

Biosecurity published reports

During 2022/23, the Council continued to monitor biosecurity related developments at national and state levels and proactively engaged with industry, community, and government on biosecurity matters.

The statutory review of the BAM Act also provided opportunities for Council’s previous reports and recommendations to be used as a solid information source for the responsible reviewing agency and its consultants.

Adaptive Learning And Virtual Reality Based Conceptual Framework For Dental Training, Nahla Barakat, Abeer Hamdy, Meriam Sherif

Artificial Intelligence

Recently, there has been increasing interest in utilizing virtual reality (VR) technology in dental education and student training. VR based training can provide students with sufficient training and hands-on experience before entering the clinical setting, which in turn helps avoid risks ranging from small errors to severe consequences. However, previous research in this area is limited and none of the previous work proposed a complete, scalable framework for This paper proposes an improved virtual environment for dental training, through an adaptive learning approach, integrated with the VR environment, which is to the best of our knowledge the first framework proposed …

Technology Specificity And Equitable Access To Pharmaceuticals, Ana Santos Rutschman

Faculty Publications

Current models of production of pharmaceuticals, particularly those dependent on intellectual property (and adjacent) protections, often contribute to the highly asymmetrical and inequitable distribution of resulting outputs. These problems are especially acute when emerging pathogens cause transnational public health crises in which there is concurrent demand for the same medicines in both lower- and higher-income countries, with populations in the Global South getting very limited timely access, if any, to preventatives and life-saving medicines—even when an outbreak disproportionately affects populations in these very countries.

This essay examines an under-theorized and under-explored way to help correct this historical and persisting deficit …

Using Biometrics, Behavioral Observations, And Multiple Molecular Techniques To Assess The Impacts Of Changes In Temperature And Salinity On The Common Bay Mussel (Mytilus Trossulus), Casey Martin

Dissertations and Theses

The intertidal zone is a place of rapid and frequent change that is home to a variety of creatures who are essential to the integrity of the habitat. Mussels are robust sessile bivalves that anchor to the rocks of the intertidal. The prominent species on the Oregon Coast, the Common Bay Mussel (Mytilus trossulus), plays an essential role as a coastal food source, water column filter, and barrier to prevent erosion due to wave action. Mytilus trossulus withstands daily shifts in temperature, salinity, and tide, as well as seasonal changes. Global climate change due to excess carbon emissions …

A Self-Regulated Learning Approach To Educational Recommender Design, Alicia Mcnett

Masters Theses & Doctoral Dissertations

Recommender systems, or recommenders, are information filtering systems prevalent today in many fields. One type of recommender found in the field of education, the educational recommender, is a key component of adaptive learning solutions as these systems avoid “one-size-fits-all” approaches by tailoring the learning process to the needs of individual learners. To function, these systems utilize learning analytics in a student-facing manner.

While existing research has shown promise and explores a variety of types of educational recommenders, there is currently a lack of research that ties educational theory to the design and implementation of these systems. The theory considered here, …

Risk Assessment Of Urban Development In The Recharge Zone Of The Karstic Edwards Aquifer: A Literature Survey And Analysis, Julie Ybarra

Water Resources Science and Technology Theses and Graduate Research Reports (Archived)

The Edwards Aquifer is a unique groundwater system and provides drinking water for millions of people in Central Texas. Central Texas has seen an increase in urban development across this region and poses a threat to its water supply and water quality. A literature review and an analysis of existing risk assessment frameworks was conducted to gather information about the Edwards Aquifer and other karst aquifers around the world. The information gathered from the literature review and analysis assisted in the development of the Edwards Aquifer Vulnerability Interface. This tool identifies vulnerable areas in the Edwards Aquifer and can strengthen …

Human Intestinal Organoids From Cronkhite-Canada Syndrome Patients Reveal Link Between Serotonin And Proliferation, Victoria Poplaski, Carolyn Bomidi, Amal Kambal, Hoa Nguyen-Phuc, Sara C Di Rienzi, Heather A Danhof, Xi-Lei Zeng, Linda A Feagins, Nan Deng, Eduardo Vilar, Florencia Mcallister, Cristian Coarfa, Soyoun Min, Hyun Jung Kim, Richa Shukla, Robert Britton, Mary K Estes, Sarah E Blutt

Faculty, Staff and Student Publications

Cronkhite-Canada Syndrome (CCS) is a rare, noninherited polyposis syndrome affecting 1 in every million individuals. Despite over 50 years of CCS cases, the etiopathogenesis and optimal treatment for CCS remains unknown due to the rarity of the disease and lack of model systems. To better understand the etiology of CCS, we generated human intestinal organoids (HIOs) from intestinal stem cells isolated from 2 patients. We discovered that CCS HIOs are highly proliferative and have increased numbers of enteroendocrine cells producing serotonin (also known as 5-hydroxytryptamine or 5HT). These features were also confirmed in patient tissue biopsies. Recombinant 5HT increased proliferation …

Convergence By Design: Who Contracts And The Plural Purposes Of Contract Law, Gregory Klass

Georgetown Law Faculty Publications and Other Works

A theory is robustly pluralist if it maintains that law is justified by multiple independent nonordered principles. Some have argued that robustly pluralist theories are deficient because they can provide no practical guidance when those principles conflict. The objection is misplaced when applied to pluralist theories of contract law.

This article demonstrates the possibility of a robustly pluralist and practically relevant theory of contract law by modeling a multipurpose law of contract. Five simple models are constructed to illustrate several purposes a contract law might serve, depending on preferences of the populace (self-interested utility maximizers, a preference for sharing, a …

Accuracy And Safety Of Non-Image Guided Trigger Finger Injections: A Cadaveric Study, Daniel D Binz, Thomas W Mitchell, Scott A Mitchell

Faculty, Staff and Students Publications

BACKGROUND: Stenosing flexor tenosynovitis is commonly treated by injection of corticosteroids into the flexor tendon sheath. However, there is no consensus in the literature regarding the optimal technique, specifically when not utilizing ultrasound guidance. Here, we present a cadaver study in which 3 common techniques of flexor sheath injection were compared with regard to their accuracy and safety profiles.

METHODS: Fifteen fresh-frozen cadaver hands (60 digits) were evenly divided into 3 groups (20 digits per group). Digits in each group were injected with methylene blue dye using 1 of the 3 techniques (palmar-to-bone, palmar supra-tendinous, and mid-axial). The fingers were …

Prospection Of Peptide Inhibitors Of Thrombin From Diverse Origins Using A Machine Learning Pipeline, Nivedha Balakrishnan, Rahul Katkar, Peter V. Pham, Taylor Downey, Prarthna Kashyap, David C. Anastasiu, Anand K. Ramasubramanian

Faculty Research, Scholarly, and Creative Activity

Thrombin is a key enzyme involved in the development and progression of many cardiovascular diseases. Direct thrombin inhibitors (DTIs), with their minimum off-target effects and immediacy of action, have greatly improved the treatment of these diseases. However, the risk of bleeding, pharmacokinetic issues, and thrombotic complications remain major concerns. In an effort to increase the effectiveness of the DTI discovery pipeline, we developed a two-stage machine learning pipeline to identify and rank peptide sequences based on their effective thrombin inhibitory potential. The positive dataset for our model consisted of thrombin inhibitor peptides and their binding affinities (KI) curated from published …

Antitumor Activity Of Carboxymethyl Pachymaran With Different Molecular Weights Based On Immunomodulatory And Gut Microbiota, Yalin Zhao, Xi Feng, Lijia Zhang, Wen Huang, Ying Liu

Faculty Research, Scholarly, and Creative Activity

Carboxymethyl pachymaran (CMP) was treated via high-temperature and cellulase hydrolysis to obtain HTCMP, HTEC-24, and HTEC-48. The chemical structure and in vivo antitumor activities of the four types of CMPs were investigated. Compared with CMP (787.9 kDa), the molecular weights of HTCMP, HTEC-24, and HTEC-48 were decreased to 429.8, 129.9, and 68.6 kDa, respectively. The viscosities and particle sizes of the CMPs could also decrease with the decline in the molecular weights. All the CMPs showed antitumor abilities, but HTEC-24 exhibited the best activity. In the animal study, when curing the spleen and thymus, CMPs displayed immunomodulatory effects by increasing …

Aims For Wildlife: Developing An Automated Interactive Monitoring System To Integrate Real-Time Movement And Environmental Data For True Adaptive Management, Michael L. Casazza, Austen A. Lorenz, Cory T. Overton, Elliott L. Matchett, Andrea L. Mott, Desmond A. Mackell, Fiona Mcduie

Faculty Research, Scholarly, and Creative Activity

To effectively manage species and habitats at multiple scales, population and land managers require rapid information on wildlife use of managed areas and responses to landscape conditions and management actions. GPS tracking studies of wildlife are particularly informative to species ecology, habitat use, and conservation. Combining GPS data with administrative data and a diverse suite of remotely sensed, geo-referenced environmental (e.g., climatic) data, would more comprehensively inform how animals interact with and utilize habitats and ecosystems and our goal was to create a conceptual model for a system that would accomplish this – the ‘Automated Interactive Monitoring System (AIMS) for …