Digital Commons Network^™

Fall 2023, Georgia Library Quarterly

Georgia Library Quarterly

No abstract provided.

My Own Private Library, Chamyre Hynson

Georgia Library Quarterly

No abstract provided.

No Right To Life: Lives Lost And The Legalized Violence That Shaped A Humanitarian Crisis In The Arizona Borderlands, Madeline Brashear Jd, Sarah Diaz Jd, Llm

Center for the Human Rights of Children

No abstract provided.

Discursive Struggles Reflected In The Communication Of Conservative Christian Parents And Their Adult Children With Differing Religious Beliefs And Values, Braedon G. Worman

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Nearly half of American adults no longer believe in their childhood faiths (Pew Research Center, 2015). The steady decline of Christianity could have considerable impacts on family life (Pew Research Center, 2022). From a postmodern critical perspective and guided by Relational Dialectics Theory 2.0, the researcher sought to discern how conservative Christian parents and their adult children with differing religious beliefs and values communicated when they discussed these differences, as well as to identify the discourses that informed and were reflected in their talk and illustrate how these discourses interplayed and animated the meaning of participants’ Christian family identities. The …

The Effects Of Early Rearing Experiences On Mutual Eye Gaze Among Captive Olive Baboons (Papio Anubis), Angela M. Achorn, Michele M. Mulholland, William D. Hopkins

Anthropology Faculty Publications

Among human and nonhuman primates, mutual eye gaze (MEG) and gaze following are believed to be important for social cognition and communicative signaling. The goals of this study were to examine how early rearing experiences contribute to individual variation in MEG and to examine the potential role of genetic factors underlying this variation. Subjects included 93 female and 23 male baboons (Papio anubis) ranging from 3 to 20 years of age. Within the sample, there were 55 mother-reared (MR) and 61 nursery-reared (NR) baboons. MEG was assessed in four 60-s test sessions. For each session, the duration, frequency, and bout …

Conducting Enchantment: Organized Sound And Ritual Spaces In Modern And Ancient Worlds, Haley Stuckey

Honors Capstones

No abstract provided.

Preparing Students For Careers In Agriculture: An Analysis Of Secondary And Postsecondary Approaches To Work-Based Learning In The United States And Rwanda, Matthew Sterling Kreifels

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

This dissertation investigates work-based learning as a method to prepare students for agricultural careers through three interconnected studies. The first two studies investigate secondary education programs in the United States, while the third study explores postsecondary education in Rwanda. In Study 1, a philosophical research approach explores how the new Supervised Agricultural Experience (SAE) approach, SAE for All, aligns five Foundational SAE components with learning theories and supports Career and Technical Education priorities. Study 2 utilizes a transcendental phenomenological approach to examine teacher perceptions of SAE for All's effectiveness for student career development. Study 3, a case study, analyzes how …

An Analysis Of Plant Response To Herbivory, Lawrence Gustavo Seminario-Romero

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Herbivory is often believed to always negatively affect the growth of plants, but there are plant species that can actually benefit from being consumed by herbivores. These plants have a phenotypic trait known as “compensatory growth.” A plant that exhibits compensatory growth is able to increase its intrinsic growth rate as a response to taking damage caused by herbivory, and as a result, produce more biomass. Very few mathematical models used to describe plant-herbivore interactions have accounted for plant compensatory growth. Moreover, these models tend to assume that herbivores follow a Holling type II functional response, which may not necessarily …

Coronary Atherosclerosis Phenotypes In Focal And Diffuse Disease, Koshiro Sakai, Takuya Mizukami, Jonathon Leipsic, Marta Belmonte, Jeroen Sonck, Bjarne L Nørgaard, Hiromasa Otake, Brian Ko, Bon-Kwon Koo, Michael Maeng, Jesper Møller Jensen, Dimitri Buytaert, Daniel Munhoz, Daniele Andreini, Hirofumi Ohashi, Toshiro Shinke, Charles A Taylor, Emanuele Barbato, Nils P Johnson, Bernard De Bruyne, Carlos Collet

Faculty, Staff and Student Publications

Background: The interplay between coronary hemodynamics and plaque characteristics remains poorly understood.

Objectives: The aim of this study was to compare atherosclerotic plaque phenotypes between focal and diffuse coronary artery disease (CAD) defined by coronary hemodynamics.

Methods: This multicenter, prospective, single-arm study was conducted in 5 countries. Patients with functionally significant lesions based on an invasive fractional flow reserve ≤0.80 were included. Plaque analysis was performed by using coronary computed tomography angiography and optical coherence tomography. CAD patterns were assessed using motorized fractional flow reserve pullbacks and quantified by pullback pressure gradient (PPG). Focal and diffuse CAD was defined according …

A Country Of Defiance : Mapping The Casamance In Senegal, Mark W. Deets

Ohio University Press Open Access Books

A historiographical analysis of human geography and a social history of nationalist separatism and cultural identity in southern Senegal.

This book is a spatial history of the conflict in Casamance, the portion of Senegal located south of The Gambia. Mark W. Deets traces the origins of the conflict back to the start of the colonial period in a select group of contested spaces and places where the seeds of nationalism and separatism took root. Each chapter examines the development of a different piece of the still unrealized Casamançais nation: river, rice field, forest, school, and stadium. Each of these locations …

The Research And Treatment Of A Qing Dynasty Garment From The Buffalo Museum Of Science, Nhat Quyen D. Nguyen

Art Conservation Master's Projects

The scope of this project was to research, analyze and treat a sleeveless garment from the Buffalo Museum of Science that is thought to be originally from China. The sleeveless garment was donated to the museum by Chauncey J. Hamlin and little information is known about the context or origin of the garment. Research was conducted to gain historical information about the type of garment and why it was made. Analysis was conducted on the fibers, metal wrapped threads and dyes to identify the materials used. The garment was treated with a heat activated adhesive support patch to stabilize the …

The Androgen Receptor Does Not Directly Regulate The Transcription Of Dna Damage Response Genes, Joshua D Samuels, Katelyn A Moore, Hannah E Ennerfelt, Alexis M Johnson, Adeline E Walsh, Richard J Price, John R Lukens

Faculty, Staff and Student Publications

INTRODUCTION: Mutations in INPP5D, which encodes for the SH2-domain-containing inositol phosphatase SHIP-1, have recently been linked to an increased risk of developing late-onset Alzheimer's disease. While INPP5D expression is almost exclusively restricted to microglia in the brain, little is known regarding how SHIP-1 affects neurobiology or neurodegenerative disease pathogenesis.

METHODS: We generated and investigated 5xFAD Inpp5d

RESULTS: SHIP-1 deletion in microglia led to substantially enhanced recruitment of microglia to Aβ plaques, altered microglial gene expression, and marked improvements in neuronal health. Further, SHIP-1 loss enhanced microglial plaque containment and Aβ engulfment when compared to microglia from Cre-negative 5xFAD Inpp5d

DISCUSSION: …

Acaa2 Is A Novel Molecular Indicator For Cancers With Neuroendocrine Phenotype, Michelle Shen, Shiqin Liu, Angus Toland, En-Chi Hsu, Alifiani B Hartono, Busola R Alabi, Merve Aslan, Holly M Nguyen, Conner J Sessions, Rosalie Nolley, Chanjuan Shi, Jiaoti Huang, James D Brooks, Eva Corey, Tanya Stoyanova

Faculty, Staff and Student Publications

BACKGROUND: Neuroendocrine phenotype is commonly associated with therapy resistance and poor prognoses in small-cell neuroendocrine cancers (SCNCs), such as neuroendocrine prostate cancer (NEPC) and small-cell lung cancer (SCLC). Expression levels of current neuroendocrine markers exhibit high case-by-case variability, so multiple markers are used in combination to identify SCNCs. Here, we report that ACAA2 is elevated in SCNCs and is a potential molecular indicator for SCNCs.

METHODS: ACAA2 expressions in tumour xenografts, tissue microarrays (TMAs), and patient tissues from prostate and lung cancers were analysed via immunohistochemistry. ACAA2 mRNA levels in lung and prostate cancer (PC) patients were assessed in published …

Biomechanics In The Onset And Severity Of Spondyloarthritis: A Force To Be Reckoned With, Priyanka Iyer, Mark Hwang, Lauren Ridley, Michael M Weisman

Faculty, Staff and Student Publications

Increasing evidence suggests that there is a pivotal role for physical force (mechanotransduction) in the initiation and/or the perpetuation of spondyloarthritis; the review contained herein examines that evidence. Furthermore, we know that damage and inflammation can limit spinal mobility, but is there a cycle created by altered spinal mobility leading to additional damage and inflammation?Over the past several years, mechanotransduction, the mechanism by which mechanical perturbation influences gene expression and cellular behaviour, has recently gained popularity because of emerging data from both animal models and human studies of the pathogenesis of ankylosing spondylitis (AS). In this review, we provide evidence …

Animal Models In Systemic Sclerosis: An Update, Xiongjie Bi, Tingting Mills, Minghua Wu

Faculty, Staff and Student Publications

Purpose of review: Systemic sclerosis (SSc) is a multisystem autoimmune connective tissue disease characterized by early inflammation followed by excessive fibrosis in the skin and internal organs. Enhancing our comprehension of SSc pathogenesis is essential to develop effective therapeutic strategies. Animal models that mimic one or more aspects of SSc have been proven to be a valuable resource for investigating disease mechanisms. This review aims to provide an updated overview of the existing SSc animal models and the potentially relevant pathways to SSc pathogenesis.

Recent findings: This review focuses on the most recently generated and investigated animal models, which delve …

Optogenetic Stimulation Of Ca1 Pyramidal Neurons At Theta Enhances Recognition Memory In Brain Injured Animals, John I Broussard, John B Redell, Jing Zhao, Rebecca West, Ryota Homma, Pramod K Dash

Faculty, Staff and Student Publications

The hippocampus plays a prominent role in learning and memory formation. The functional integrity of this structure is often compromised after traumatic brain injury (TBI), resulting in lasting cognitive dysfunction. The activity of hippocampal neurons, particularly place cells, is coordinated by local theta oscillations. Previous studies aimed at examining hippocampal theta oscillations after experimental TBI have reported disparate findings. Using a diffuse brain injury model, the lateral fluid percussion injury (FPI; 2.0 atm), we report a significant reduction in hippocampal theta power that persists for at least three weeks after injury. We questioned whether the behavioral deficit associated with this …

Comprehensive Evaluation And New Recommendations In The Use Of Gafchromic Ebt3 Film, Kevin Liu, Patrik Gonçalves Jorge, Ramesh Tailor, Raphaël Moeckli, Emil Schüler

Faculty, Staff and Student Publications

BACKGROUND: Gafchromic film's unique properties of tissue-equivalence, dose-rate independence, and high spatial resolution make it an attractive choice for many dosimetric applications. However, complicated calibration processes and film handling limits its routine use.

PURPOSE: We evaluated the performance of Gafchromic EBT3 film after irradiation under a variety of measurement conditions to identify aspects of film handling and analysis for simplified but robust film dosimetry.

METHODS: The short- (from 5 min to 100 h) and long-term (months) film response was evaluated for clinically relevant doses of up to 50 Gy for accuracy in dose determination and relative dose distributions. The dependence …

2023 November, Morehead State University. Office Of Communications & Marketing.

Morehead State Press Release Archive, 1961 to the Present

Press releases for November of 2023.

After Great Pain: The Uses Of Religious Folklore In Kenji Mizoguchi’S Sansho The Bailiff (Jp 1954) And Kaneto Shindo’S Onibaba (Jp 1964), Teng-Kuan Ng

Research Collection College of Integrative Studies

This article studies the adaptations and applications of religious folklore in two mas-terworks of Japanese cinema: Kenji Mizoguchi’s Sansho Dayu (Sansho the Bailiff, JP 1954) and Kaneto Shindo’s Onibaba (JP 1964). While academic approaches will often draw a strict line between narrative genres and discursive forms, these films, I argue, draw creatively from Japanese tradition for both critical and constructive purposes in the postwar context. Besides mounting trenchant criticisms of Japan’s erstwhile militaristic violence and imperial ambitions, both filmmakers present their respective female protagonists as models for spiritual and sociocultural transformation in the face of anomie. Embodying humanistic compassion on …

Inverted Totems: On The Significance Of “Woke” In The Culture Wars, Todd Madigan

Sociology

Early in the 21st century, the term woke became ubiquitous within the context of the culture wars. However, the meaning of the term has been notoriously difficult to pin down, and its use as a descriptor of the most bewildering range of phenomena has led many commentators to declare the word meaningless. My claim is that instead of focusing on what woke means, we should focus on what it does. And in order to demonstrate what woke does, I situate it within a novel typology of totems. As a totem, woke serves to create and constitute the self-awareness of an …

Interplay Of Hypoxia-Inducible Factors And Oxygen Therapy In Cardiovascular Medicine, Yafen Liang, Wei Ruan, Yandong Jiang, Richard Smalling, Xiaoyi Yuan, Holger K Eltzschig

Faculty, Staff and Student Publications

Mammals have evolved to adapt to differences in oxygen availability. Although systemic oxygen homeostasis relies on respiratory and circulatory responses, cellular adaptation to hypoxia involves the transcription factor hypoxia-inducible factor (HIF). Given that many cardiovascular diseases involve some degree of systemic or local tissue hypoxia, oxygen therapy has been used liberally over many decades for the treatment of cardiovascular disorders. However, preclinical research has revealed the detrimental effects of excessive use of oxygen therapy, including the generation of toxic oxygen radicals or attenuation of endogenous protection by HIFs. In addition, investigators in clinical trials conducted in the past decade have …

Design Of Impact-Free Gaits For Planar Bipeds And Their Stabilization Using Impulsive Control, Aakash Khandelwal, Nilay Kant, Ranjan Mukherjee

Mechanical and Aerospace Engineering Faculty Research & Creative Works

The problem of designing and stabilizing impact-free gaits is considered for point-foot planar bipeds. A set of geometric constraints, which eliminate impact forces at the time of leg interchange, are used to design the gaits. A family of gaits, where the stride length and walking speed can be chosen independently for each gait, is guaranteed to exist. A continuous controller is used to enforce the constraints associated with a desired gait and intermittent impulsive inputs are applied to stabilize the gait. A five-link biped example is used to illustrate the procedure for designing impact-free gaits. The effectiveness of the continuous …

Pro-Cap: Leveraging A Frozen Vision-Language Model For Hateful Meme Detection, Rui Cao, Ming Shan Hee, Adriel Kuek, Wen Haw Chong, Roy Ka-Wei Lee, Jing Jiang

Research Collection School Of Computing and Information Systems

Hateful meme detection is a challenging multimodal task that requires comprehension of both vision and language, as well as cross-modal interactions. Recent studies have tried to fine-tune pre-trained vision-language models (PVLMs) for this task. However, with increasing model sizes, it becomes important to leverage powerful PVLMs more efficiently, rather than simply fine-tuning them. Recently, researchers have attempted to convert meme images into textual captions and prompt language models for predictions. This approach has shown good performance but suffers from non-informative image captions. Considering the two factors mentioned above, we propose a probing-based captioning approach to leverage PVLMs in a zero-shot …

Oxidative Stress In Health And Disease, V. Prakash Reddy

Chemistry Faculty Research & Creative Works

Oxidative stress, resulting from the excessive intracellular accumulation of reactive oxygen species (ROS), reactive nitrogen species (RNS), and other free radical species, contributes to the onset and progression of various diseases, including diabetes, obesity, diabetic nephropathy, diabetic neuropathy, and neurological diseases, such as Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), and Parkinson's disease (PD). Oxidative stress is also implicated in cardiovascular disease and cancer. Exacerbated oxidative stress leads to the accelerated formation of advanced glycation end products (AGEs), a complex mixture of crosslinked proteins and protein modifications. Relatively high levels of AGEs are generated in diabetes, obesity, AD, and other …

Aberrant Mitochondrial Dynamics Contributes To Diaphragmatic Weakness Induced By Mechanical Ventilation., Haikel Dridi, Marc Yehya, Robert J. Barsotti, Yang Liu, Steven Reiken, Lan Azria, Qi Yuan, Laith Bahlouli, Rajesh Kumar Soni, Andrew R Marks, Alain Lacampagne, Stefan Matecki

PCOM Scholarly Works

In critical care patients, the “”temporary inactivity of the diaphragm caused by mechanical ventilation (MV) triggers a series of events leading to diaphragmatic dysfunction and atrophy, commonly known as ventilator-induced diaphragm dysfunction (VIDD). While mitochondrial dysfunction related to oxidative stress is recognized as a crucial factor in VIDD, the exact molecular mechanism remains poorly understood. In this study, we observe that 6 h of MV triggers aberrant mitochondrial dynamics, resulting in a reduction in mitochondrial size and interaction, associated with increased expression of dynamin-related protein 1 (DRP1). This effect can be prevented by P110, a molecule that inhibits the recruitment …

Cfa-Treated Mice Induce Hyperalgesia In Healthy Mice Via An Olfactory Mechanism, Yangmiao Zhang, Wentai Luo, Maryt M. Heinricher, Andrey E. Ryabinin

Chemistry Faculty Publications and Presentations

Background

Social interactions with subjects experiencing pain can increase nociceptive sensitivity in observers, even without direct physical contact. In previous experiments, extended indirect exposure to soiled bedding from mice with alcohol withdrawal-related hyperalgesia enhanced nociception in their conspecifics. This finding suggested that olfactory cues could be sufficient for nociceptive hypersensitivity in otherwise untreated animals (also known as “bystanders”).

Aim

The current study addressed this possibility using an inflammation-based hyperalgesia model and long- and short-term exposure paradigms in C57BL/6J mice.

Materials & Method

Adult male and female mice received intraplantar injection of complete Freund's adjuvant (CFA) and were used as stimulus …

Marine Mammals Of The Emirates: Whales, Dolphins, Porpoises And Dugongs, Ada Natoli, Shamsa Al Hameli

All Works

Marine mammals have always captured the imagination of the people they share their environment with, but few people know that various species populate the waters of the United Arab Emirates (UAE). The world’s second largest population of dugongs reside in the Abu Dhabi Emirate, while two species of dolphins (Indian Ocean humpback and Indo-Pacific bottlenose dolphin) and the elusive finless porpoises inhabit Abu Dhabi and Dubai waters. Facing both the Sea of Oman and the Arabian Gulf, the UAE hosts a total of 18 species of marine mammals. These include the biggest animal on Earth, the blue whale, Bryde’s, humpback …

The Emirates At 2050: Balancing Development And Environmental Stewardship, John A. Burt, Noura Al-Mansoori, Ivonne Bejarano, Gary Brown, Oscar Campbell, Johannes Els, Gary R. Feulner, Guillermo Friis-Montoya, Aaron Henderson, Natural History Museum Abu Dhabi Howarth, Brigitte (Department Of Culture And Tourism, , Abu Dhabi, United Arab Emirates , Abu Dhabi, United Arab Emirates, David M. John, Jacky Judas, Daniel Mateos-Molina, Matthew Mitchell, Ada Natoli, Francesco Paparella, Fadi (Hefaiyah Mountain Conservation Centre Yaghmour, , Environment And Protected Areas Authority, Kalba, Sharjah, United Arab Emirates , Environment And Protected Areas Authority, Kalba, Sharjah, United Arab Emirates

All Works

The United Arab Emirates (UAE) faces the challenge of balancing rapid economic development with environmental preservation and conservation in the Anthropocene era. The nation’s unique ecosystems, characterized by arid desert, rugged mountains, and diverse marine habitats, are vulnerable to disturbances such as urbanization, habitat degradation, groundwater extraction and climate change. To chart a more sustainable course for the Emirates by 2050, the paper proposes policy recommendations such as adopting a national strategy for sustainable development, strengthening environmental policies, investing in urban planning and design, promoting sustainable water management, encouraging use of nature-based solutions, addressing climate change, fostering environmental education, supporting …

Commentary: A Different Animal But The Same Beast, Vicente Orozco-Sevilla, Joseph S Coselli

Faculty, Staff and Students Publications

No abstract provided.

Therapeutic Implications Of Impaired Nuclear Receptor Function And Dysregulated Metabolism In Wilson’S Disease, Clavia Ruth Wooton-Kee

Faculty, Staff and Students Publications

Copper is an essential trace element that is required for the activity of many enzymes and cellular processes, including energy homeostasis and neurotransmitter biosynthesis; however, excess copper accumulation results in significant cellular toxicity. The liver is the major organ for maintaining copper homeostasis. Inactivating mutations of the copper-transporting P-type ATPase, ATP7B, result in Wilson’s disease, an autosomal recessive disorder that requires life-long medicinal therapy or liver transplantation. Current treatment protocols are limited to either sequestration of copper via chelation or reduction of copper absorption in the gut (zinc therapy). The goal of these strategies is to reduce free copper, redox …