Digital Commons Network^™

Oregon State Rank Assessment For Paiute Sculpin (Cottus Beldingii), Misty Nelson

Institute for Natural Resources Publications

Oregon state conservation status assessment for Paiute sculpin (Cottus beldingii) using NatureServe methodology, 2023.

Containerized Satsuma Mandarin Production Under Protective Screens As A Management Strategy, Anna Timmerman

LSU Master's Theses

Many of the world’s citrus growing regions are experiencing challenges related to citrus greening, also known as Huanglongbing (HLB) caused by the presumed bacterial agent Candidatus Liberibacter spp. HLB is vectored by the Asian citrus psyllid (Diaphorina citri) and through propagation of infected citrus material. HLB impacts tree health as well as fruit development, ripening, and quality of the resulting citrus fruit, often leading to an unmarketable product. Producers are growing citrus in high density orchards underneath protective screening material that excludes the Asian citrus psyllid, preventing new HLB infections. Four ultra-high containerized tree spacings of 2 feet …

Rare De Novo Gain-Of-Function Missense Variants In Dot1l Are Associated With Developmental Delay And Congenital Anomalies, Zelha Nil, Ashish R Deshwar, Yan Huang, Scott Barish, Xi Zhang, Sanaa Choufani, Polona Le Quesne Stabej, Ian Hayes, Patrick Yap, Chad Haldeman-Englert, Carolyn Wilson, Trine Prescott, Kristian Tveten, Arve Vøllo, Devon Haynes, Patricia G Wheeler, Jessica Zon, Cheryl Cytrynbaum, Rebekah Jobling, Moira Blyth, Siddharth Banka, Alexandra Afenjar, Cyril Mignot, Florence Robin-Renaldo, Boris Keren, Oguz Kanca, Xiao Mao, Daniel J Wegner, Kathleen Sisco, Marwan Shinawi, Undiagnosed Disease Network, Michael F Wangler, Rosanna Weksberg, Shinya Yamamoto, Gregory Costain, Hugo J Bellen

Faculty, Staff and Students Publications

Misregulation of histone lysine methylation is associated with several human cancers and with human developmental disorders. DOT1L is an evolutionarily conserved gene encoding a lysine methyltransferase (KMT) that methylates histone 3 lysine-79 (H3K79) and was not previously associated with a Mendelian disease in OMIM. We have identified nine unrelated individuals with seven different de novo heterozygous missense variants in DOT1L through the Undiagnosed Disease Network (UDN), the SickKids Complex Care genomics project, and GeneMatcher. All probands had some degree of global developmental delay/intellectual disability, and most had one or more major congenital anomalies. To assess the pathogenicity of the DOT1L …

Tfeb And Tfe3 Control Glucose Homeostasis By Regulating Insulin Gene Expression, Adrien Pasquier, Nunzia Pastore, Luca D'Orsi, Rita Colonna, Alessandra Esposito, Veronica Maffia, Rossella De Cegli, Margherita Mutarelli, Susanna Ambrosio, Gennaro Tufano, Antonio Grimaldi, Marcella Cesana, Davide Cacchiarelli, Nathalie Delalleau, Gennaro Napolitano, Andrea Ballabio

Duncan NRI Faculty and Staff Publications

To fulfill their function, pancreatic beta cells require precise nutrient-sensing mechanisms that control insulin production. Transcription factor EB (TFEB) and its homolog TFE3 have emerged as crucial regulators of the adaptive response of cell metabolism to environmental cues. Here, we show that TFEB and TFE3 regulate beta-cell function and insulin gene expression in response to variations in nutrient availability. We found that nutrient deprivation in beta cells promoted TFEB/TFE3 activation, which resulted in suppression of insulin gene expression. TFEB overexpression was sufficient to inhibit insulin transcription, whereas beta cells depleted of both TFEB and TFE3 failed to suppress insulin gene …

Srcap Mutations Drive Clonal Hematopoiesis Through Epigenetic And Dna Repair Dysregulation, Chun-Wei Chen, Linda Zhang, Ravi Dutta, Abhishek Niroula, Peter G Miller, Christopher J Gibson, Alexander G Bick, Jaime M Reyes, Yi-Tang Lee, Ayala Tovy, Tianpeng Gu, Sarah Waldvogel, Yi-Hung Chen, Bryan J Venters, Pierre-Olivier Estève, Sriharsa Pradhan, Michael-Christopher Keogh, Pradeep Natarajan, Koichi Takahashi, Adam S Sperling, Margaret A Goodell

Faculty, Staff and Students Publications

Somatic mutations accumulate in all cells with age and can confer a selective advantage, leading to clonal expansion over time. In hematopoietic cells, mutations in a subset of genes regulating DNA repair or epigenetics frequently lead to clonal hematopoiesis (CH). Here, we describe the context and mechanisms that lead to enrichment of hematopoietic stem cells (HSCs) with mutations in SRCAP, which encodes a chromatin remodeler that also influences DNA repair. We show that SRCAP mutations confer a selective advantage in human cells and in mice upon treatment with the anthracycline-class chemotherapeutic doxorubicin and bone marrow transplantation. Furthermore, Srcap mutations lead …

Relation Between Fine And Gross Motor Skills And Observation Of Sociocultural Factors Across The First Year Of Infancy, Erika Garcia Mora

LSU Doctoral Dissertations

The development of independent arms-free sitting, which frees an infant’s arms to explore objects in their environment (Soska & Adolph, 2014) is observed to propagate an increase in the frequency of manual and manipulatory actions (Marcinowski, et al., 2019; Mlincek, et. al., 2022). Active object exploration provides the infant with more sensory information of the fundamental characteristics of objects in their environment. Thus, this dissertation examined the quality and quantity of object exploration across seated postures.

Additionally, the literature claiming that infants raised in low-income households having fewer resources for effective development is being countered by considering a more holistic …

Ex Vivo To In Vivo Model Of Malignant Peripheral Nerve Sheath Tumors For Precision Oncology, Alex T Larsson, Himanshi Bhatia, Xiaochun Zhang, Daniel Schefer, Kuangying Yang, Yang Lyu, Carina A Dehner, John S A Chrisinger, Kevin He, Angela C Hirbe, Et Al.

2020-Current year OA Pubs

BACKGROUND: Malignant peripheral nerve sheath tumors (MPNST) are aggressive soft tissue sarcomas that often develop in patients with neurofibromatosis type 1 (NF1). To address the critical need for novel therapeutics in MPNST, we aimed to establish an ex vivo 3D platform that accurately captured the genomic diversity of MPNST and could be utilized in a medium-throughput manner for drug screening studies to be validated in vivo using patient-derived xenografts (PDX).

METHODS: Genomic analysis was performed on all PDX-tumor pairs. Selected PDX were harvested for assembly into 3D microtissues. Based on prior work in our labs, we evaluated drugs (trabectedin, olaparib, …

Infection And Inflammation Stimulate Expansion Of A Cd74+ Paneth Cell Subset To Regulate Disease Progression, Iyshwarya Balasubramanian, Shengxiang Sun, Ta-Chiang Liu, Et Al.

2020-Current year OA Pubs

Paneth cells (PCs), a specialized secretory cell type in the small intestine, are increasingly recognized as having an essential role in host responses to microbiome and environmental stresses. Whether and how commensal and pathogenic microbes modify PC composition to modulate inflammation remain unclear. Using newly developed PC-reporter mice under conventional and gnotobiotic conditions, we determined PC transcriptomic heterogeneity in response to commensal and invasive microbes at single cell level. Infection expands the pool of CD74

Reverse Engineering And 3d Printing Of Medical Devices For Drug Delivery And Drug-Embedded Anatomic Implants, Anusha Elumalai, Yash Nayak, Aravinda K Ganapathy, David Chen, Karthik Tappa, Udayabhanu Jammalamadaka, Grace Bishop, David H Ballard

2020-Current year OA Pubs

In recent years, 3D printing (3DP) has advanced traditional medical treatments. This review explores the fusion of reverse engineering and 3D printing of medical implants, with a specific focus on drug delivery applications. The potential for 3D printing technology to create patient-specific implants and intricate anatomical models is discussed, along with its ability to address challenges in medical treatment. The article summarizes the current landscape, challenges, benefits, and emerging trends of using 3D-printed formulations for medical implantation and drug delivery purposes.

Informative Material For Patient Empowerment In Sensitive Situations, Iris Reychav, Lin Zhu, Avi Parush, Roger Mchaney, Daphne R. Raban, Amy Lauren Shapira, Rami Moshonov

Patient Experience Journal

Women diagnosed with HPV face a hard-to-understand disease that may impact their psychological and physical health and may pose challenges communicating with healthcare providers in sensitive settings. We posit patient empowerment through targeted educational materials can improve sensitive communication and lead to better health outcomes. This study measured the impact of a patient-empowerment process used in a gynecology clinic for HPV patients to improve sensitive communication during medical-related meetings and on subsequent patient empowerment outcomes. The empowerment process was based on expert-vetted informative material made accessible in the physician’s waiting room on tablet devices. Communication between physicians and patients was …

The President's Fourth Branch?, Bijal Shah

Fordham Law Review

Unitary executive theory has taken hold of the administrative state, motivated by the view that agencies constitute a rogue fourth branch of government. Emboldened by the U.S. Supreme Court, the President has begun to interfere with administrative accountability to important criteria including statutory procedural requirements that impact both public participation and administrative due process, the expectation that agencies engage neutral expertise to implement the law, and the obligations of judicial review. As a result, this Essay argues, rather than constituting a fourth branch that is unaccountable to the President, the administrative state has been encouraged by the President and courts …

Renal Disease Rehabilitation And Delaying Dialysis, Spencer Brown, Natalie Sterner

Clinical Research in Practice: The Journal of Team Hippocrates

A clinical decision report using:

Greenwood SA, Koufaki P, Mercer TH, et al. Effect of exercise training on estimated GFR, vascular health, and cardiorespiratory fitness in patients with CKD: a pilot randomized controlled trial. Am J Kidney Dis. 2015;65(3):425-434. https://doi.org/10.1053/j.ajkd.2014.07.015

for a patient with non-dialysis CKD interested in slowing the progression toward necessary dialysis.

The Ketogenic Diet Effect On Organ Chemistries, Rundk Hwaiz, Mohammad Mostafa, Sazan Talaat, Mohammed Merza

Polytechnic Journal

Background: ketogenic diet refers to the diet plan that emphasizes foods that are high in fats, moderate proteins and very low carbohydrates to consume more calories from fat rather than carbohydrates and is commonly used as a weight-loss plan and in rare cases, as a treatment for some diseases. Objective: The aim of this study was to evaluate or assess organ functions in the individuals following ketogenic diet. Patients and methods: A total 31 samples were collected from individuals following ketogenic diet in male and femal aged from 20 to 55, and a control group which composed of 10 healthy …

Faculty University Service Roster - November 2023, Faculty Senate

Faculty Senate Documents

A list distributed in November 2023 by the Faculty Senate of members of the governance body and affiliated committees.

Novel Method Of The Quantification Of Turbulent Fluid Flow In Silicone Artery Phantoms Using Acoustic Analysis, Julia Wong

Master's Theses

Cardiovascular disease is the leading cause of death globally and is responsible for taking 17.9 million lives per year. Despite the use of clinical treatments and detection methods, there remains a large population of individuals that suffer from CVD whose symptoms are left undetected and untreated prior to a life-threatening cardiac event. This highlights a need for an early detection method that can prevent the manifestation and worsening of the disease as well as address limitations of current early detection methods. An area of interest for early detection of CVD is subclinical atherosclerosis, which is the long, early, asymptomatic stage …

A Predictive Technique Using Random Forest Classifier For Phishing Malicious Attack, Abdullah Alhaj, Mua’Ad Abu-Faraj, Basel J. A. Ali

Applied Mathematics & Information Sciences

A person with an email account is always vulnerable to fraud. An email account can be exploited by using a type of social engineering attack where the attackers trick the victims to steal user credentials by masquerading as a trusted entity. Email phishing has become the major action performed in various sectors such as banking, business, any enterprise or social media etc. While the action of phishing, the attackers make use of another technique called email spoofing. Email spoofing is not much different from email phishing since the email spoofing involves the usage of forged email header pretending as an …

Growth Performance, Feed Utilization, Hematological Parameters, And Histological Features Of Nile Tilapia (Oreochromis Niloticus) Fed Diets With Supplementary Herbal Extracts Under Prolonged Water Exchange, Mohamed F.A. Abdel-Aziz, Mohammed F. El Basuini, Islam I. Teiba, Mohamed M.M. Metwally

Faculty Journal Articles

No abstract provided.

Center For Grassland Studies, November 2023

Center for Grassland Studies: Newsletters

Contents

Experiential Learning for Grassland Conservation by David Wedin

Center for Grassland Studies Policy Advisory Committee

Director’s Column by David Wedin

New Woody Invasions Ecologist Brings Additional Capacity for Grassland Conservation by Dillon Fogarty

Twidwell Racks-up awards for his work in Grassland Conservation by Geitner Simmons

Platte Basin Timelapse premieres New Film on Nine-Mile Prairie by David Wedin

CRAWL: Update on the Network for Integrated Agricultural Resilience Research by Craig Allen

CGS Outreach by Jerry Volesky

Center for Grassland Studies Awards 19 Scholarships Totaling $17,500 for 2023-2024 by David Wedin

Award winners:

Joseph O. Young Fund = Makenna Anderson, Makennen …

Periodontal Disease And Alzheimer’S Disease, Lexis Labonte, Jaycee Cole

Dental Hygiene Student Research Posters

There is a direct correlation between patients with periodontal disease and negative cognitive decline or Alzheimer’s disease. Research has proven that those who suffer from Alzheimer’s/dementia have a reduced dentition which negatively impacts masticatory function. With impaired masticatory function, it leads to poor nutrition which has a direct effect on cerebral stimulation and blood flow which worsens the effects of Alzheimer’s. The bacteria that is present during periodontitis, causes a spike in inflammatory cytokines. These cytokines invade the brain and trigger CNS inflammation which leads to cognitive decline.

Development Of An Angiogenic Tissue-On-A-Chip Microenvironment, Eric Stuehr

Master's Theses

Preclinical testing is necessary to investigate the safety and efficacy of novel therapeutics before moving to clinical trials, yet approximately 90% of these therapies fail once tested in humans. This has led to increased interest in developing robust preclinical models that accurately mimic the complex human in vivo physiology. Microfluidic devices that can introduce dynamic conditions to 3D cell/organoid cultures, also known as tissue-on-a-chip, have emerged as physiologically relevant in vitro preclinical models that can achieve high throughput screening of therapeutics. The research presented here aimed to develop an angiogenic environment within a novel microfluidic device to stimulate formation of …

Lindenwood Student Government Newsletter -November 2023, Lindenwood University

Lindenwood Student Government Newsletters

A newsletter from the Lindenwood University Student Government.

Uni Impact: Faculty/Staff Scholarly Publications And Featured Awards Newsletter, V1i3-4, 2022, Rod Library. Research & Sponsored Programs. Uni Foundation. University Of Northern Iowa.

UNI Impact: Faculty/Staff Scholarly Publications and Featured Awards Newsletter

Highlights the scholarship, research, and other scholarly work produced by University of Northern Iowa faculty, students, and staff.

This issue covers the period of April - December 2022.

Classroom Community And Online Learning: A Synthesis Of Alfred Rovai’S Research, Patrick R. Lowenthal, Arielle Horan, Marc C. Dearmond, Amy Lomellini, Dave Egan, Mickinzie Johnson, Krisha Noelle Moeller, Fayth Keldgord, Jessica Kuohn, Shawna Jensen, Auston Stamm, Daquita Pounds

Educational Technology Faculty Publications and Presentations

Increasingly researchers and practitioners have highlighted the importance of developing a sense of community in online courses and programs. However, many questions remain about the best ways to develop community in online courses. A recent literature review highlighted how influential Alfred P. Rovai’s research has been to researchers of connectedness and community in online higher education. However, some of this foundational research is over 20 years old. Given this, we conducted a review of Rovai’s research on community to take a deeper analysis of Rovai’s research and to identify themes across the studies, future areas of research, and implications for …

Interspecies Relations In The Midst Of The Russia–Ukraine War, Tanya Richardson

Anthropology Faculty Publications

No abstract provided.

Once On This Island

Theatre and Performance Studies Programs

This Tony Award-winning musical is the sweeping, universal tale of Ti Moune, a fearless peasant girl in search of her place in the world, and ready to risk it all for love. Guided by the mighty island gods, Ti Moune sets out on a remarkable journey to reunite with the man who has captured her heart. With a score that bursts with life through its Caribbean rhythms and instruments, Once on This Island: The Musical is a timeless testament to theatre’s unlimited possibilities and that a beautiful story simply told has the power to inspire and heal all. Read more …

Carolyn Williams Collection, 1983-2012, Allen Thomas, Cynthia Tobar

Finding Aids

Finding aid for the Carolyn Williams collection prepared by Bronx Community College Archives.

The Influence Of Nature On Well-Being During The Covid-19 Pandemic: Views From New England Island Residents, Nicole Kras, Jennifer Keenan

New Community College

Researchers are beginning to explore the impact of the COVID-19 pandemic on island populations, but little is known about the experiences of the residents of Nantucket and Martha’s Vineyard in the Northeast region of the United States. In this study, islanders (N=41) provide insight into how spending time in nature influenced their well-being, especially their mental well-being, during this unprecedented time. For the majority of participants, the influence of nature on their well-being increased during the pandemic. Additionally, participants shared benefits of island living such as isolation from the mainland, as well as challenges such as food and supply shortages. …

Stop-Ad Portal: Selecting The Optimal Pharmaceutical For Preclinical Drug Testing In Alzheimer's Disease., Sara K Quinney, Kandasamy Murugesh, Adrian Oblak, Kristen D. Onos, Michael Sasner, Anna K Greenwood, Kara H Woo, Stacey J Sukoff Rizzo, Paul R Territo

Faculty Research 2023

We propose an unbiased methodology to rank compounds for advancement into comprehensive preclinical testing for Alzheimer's disease (AD). Translation of compounds to the clinic in AD has been hampered by poor predictive validity of models, compounds with limited pharmaceutical properties, and studies that lack rigor. To overcome this, MODEL-AD's Preclinical Testing Core developed a standardized pipeline for assessing efficacy in AD mouse models. We hypothesize that rank-ordering compounds based upon pharmacokinetic, efficacy, and toxicity properties in preclinical models will enhance successful translation to the clinic. Previously compound selection was based solely on physiochemical properties, with arbitrary cutoff limits, making ranking …

Kentucky Warbler (Vol. 99, No. 4), Department Of Library Special Collections

The Kentucky Warbler

No abstract provided.

Fisheries Science Update - Pilbara Demersal Scalefish Resource - November 2023, Department Of Primary Industries And Regional Development, Western Australia

Fisheries Science Updates

Key points: 2023 stock assessment outcomes:

• The Pilbara Demersal Scalefish Resource (PDSR) spans from the North West Cape to 120ºE and comprises over 60 demersal scalefish species, including indicator species red emperor, rankin cod, and bluespotted emperor.
• The PDSR is accessed by recreational fishers, charter operators and three commercial fisheries: Pilbara Fish Trawl (Interim) Managed Fishery, Pilbara Trap Managed Fishery, and the Pilbara Line Fishery.
• The PDSR is a key ‘food bowl’ for Western Australia, supplying the local market with about 2,500 tonnes of demersal scalefish annually.
• The PDSR provides unique and valuable recreational fishing opportunities at locations such as …