Digital Commons Network^™

Mutation Of Key Signaling Regulators Of Cerebrovascular Development In Vein Of Galen Malformations, Shujuan Zhao, Po-Ying Fu, Yung-Chun Wang, Sheng Chih Jin, Et Al.

2020-Current year OA Pubs

To elucidate the pathogenesis of vein of Galen malformations (VOGMs), the most common and most severe of congenital brain arteriovenous malformations, we performed an integrated analysis of 310 VOGM proband-family exomes and 336,326 human cerebrovasculature single-cell transcriptomes. We found the Ras suppressor p120 RasGAP (RASA1) harbored a genome-wide significant burden of loss-of-function de novo variants (2042.5-fold, p = 4.79 x 10

Vol. 60 No. 2 - Whole No. 405, Megan Abrahamson

Mythprint

Mythprint is the quarterly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local discussion groups.

Vol. 59 No. 4 - Whole No. 403, Megan Abrahamson

Mythprint

Mythprint is the quarterly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local discussion groups.

The Beacon, November 16, 2023, Beacon Staff

The Beacon, 2023-2024

Underrated Thanksgiving traditions; Upcoming engineering program; "1989" re-release of ragged love songs; "The Marvels" falls short of being "marvelous"; Christmas concert exemplifies ensemble; Quiz: What Taylor Swift era are you?; NW Students excited to serve in the spring; Thanksgiving traditions vary among students; Business celebrated with Global Entrepreneurship Week; Engineering program preview; Everyone should have a mullet; Women in male dominated careers; Raider volleyball wins GPAC tournament; RSC fitness center treatment and upkeep; Men's soccer is in the national tournament; Documentary dispels misconceptions;

Moving Beyond The 2018 Minimum International Care Considerations For Osteoporosis Management In Duchenne Muscular Dystrophy (Dmd): Meeting Report From The 3rd International Muscle-Bone Interactions Meeting 7th And 14th November 2022, Kim Phung, Nicola Crabtree, Anne M. Connolly, Pat Furlong, Eric P. Hoffman, Stefan A. Jackowski, Soher Nagi Jayash, Alex Johnson, Khaldoun Koujok, Craig F. Munns, Erik Niks, Frank Rauch, Rachel Schrader, Cathy Turner, Elizabeth Vroom, David R. Weber, Brenda L. Wong, Michela Guglieri, Leanne M. Ward, Sze Choong Wong

Pharmacy Faculty Scholarship

This current manuscript summarizes the proceedings of the “Third Muscle-bone interactions in Duchenne Muscular Dystrophy Symposium: Moving Beyond the 2018 Minimum International Standards of Care for Osteoporosis Management”, an event co-organized by the World Duchenne Organization (www.worldduchenne.org) and the International Conference on Children’s Bone Health (www.theiscbh.org). This virtual symposium, held on November 7th and 14th 2022, brought together a total of 385 delegates representing 55 countries registered for the symposium, which included 239 clinicians, 70 researchers, 40 patient representatives and others from pharmaceutical companies and regulators. This symposium aimed to review the evidence base that informed the 2018 international minimum …

The Minutes Of The Marshall University Staff Council Meeting, November 2023, Marshall University Staff Council

Staff Council Minutes

No abstract provided.

Provoking Gut-Level Reactions: A Study On Journalistic Framing During The 2020 Meatpacking Crisis, Michelle Rossi, Patrick Ferrucci

Journalism and Communication Faculty Publications

This study investigates news frames used by mainstream news media in the United States to portray the 2020 meatpacking crisis. By integrating framing and animal standpoint theory, it reveals the mechanisms that perpetuate social ignorance about daily practices within the meat industry, particularly those that exclude the perspectives of farmed animals. Through an engagement with intersectional ecofeminism and Critical Animal and Media Studies (CAMS), the investigation probes the cyclical patterns of violence inflicted upon farmed animals in the meat industry as portrayed by news outlets, a phenomenon that simultaneously impacts marginalized human communities. The inclusion of farmed animals as news …

What Could Ai Mean For Animals?, Lewis Bollard

General – Farm Animal Issues

No abstract provided.

The Current - Volume 34 Issue 6, Nova Southeastern University

Student Newspapers

No abstract provided.

Effects Of Doxorubicin On Extracellular Matrix Regulation In Primary Cardiac Fibroblasts From Mice, Cameron Skaggs, Steve Nick, Conner Patricelli, Laura Bond, Kali Woods, Luke Woodbury, Julia Thom Oxford, Xinzhu Pu

Biomedical Research Institute Publications and Presentations

Objective Doxorubicin (DOX) is a highly effective chemotherapeutic used to treat many adult and pediatric cancers. However, its use is limited due to a dose-dependent cardiotoxicity, which can lead to lethal cardiomyopathy. In contrast to the extensive research efforts on toxic effects of DOX in cardiomyocytes, its effects and mechanisms on cardiac extracellular matrix (ECM) homeostasis and remodeling are poorly understood. In this study, we examined the potential effects of DOX on cardiac ECM to further our mechanistic understanding of DOX-induced cardiotoxicity.

Results DOX-induced significant down-regulation of several ECM related genes in primary cardiac fibroblasts, including Adamts1, Adamts5, Col4a1, Col4a2, …

The Comment, November 16, 2023, Bridgewater State University

The Comment

No abstract provided.

Engaging Students In A Genetics Course-Based Undergraduate Research Experience Utilizing Caenorhabditis Elegans In Hybrid Learning To Explore Human Disease Gene Variants, Natalie Forte, Virginia Veasey, Bethany Christie, Amira Carter, Marli Hanks, Alan Holderfield, Taylor Houston, Anil Challa, Ashley Turner

Research, Publications & Creative Work

Genetic analysis in model systems using bioinformatic approaches provides a rich context for a concrete and conceptual understanding of gene structure and function. With the intent to engage students in research and explore disease biology utilizing the nematode Caenorhabditis elegans model, we developed a semester-long course-based undergraduate research experience (CURE) in a hybrid (online/in-person) learning environment—the gene-editing and evolutionary nematode exploration CURE (GENE-CURE). Using a combination of bioinformatic and molecular genetic tools, students performed structure-function analysis of disease-associated variants of uncertain significance (VUS) in human orthologs. With the aid of a series of workshop-style research sessions, students worked in teams …

Mid-Infrared Gas Sensing Based On Electromagnetically Induced Transparency In Coupled Plasmonic Resonators, Sarah Shafaay, Sherif Mohamed, Mohamed Swillam

Faculty Journal Articles

No abstract provided.

The Grizzly, November 16, 2023, Marie Sykes, Sidney Belleroche, Isabel Martinez-Robles, Erin Corcoran, Zachary Hassett, Andrew J. Perez, Charlotte Dilello, Dominic Minicozzi

Ursinus College Grizzly Newspaper, 1978 to Present

Fantastic Strings Ensemble • Crossword • Celebration of Lights (In Photos) • A Conversation With Ursinus' Archivist, Carolyn Weigel • Food Forest Continues to Grow • The Creative Collegeville Italian Bakery • From Opponent to Family Member: Natalie Mehl's Journey • Ursinus Football Punches Their Ticket to the Postseason

Oregon State Rank Assessment For Blue Mountainsnail (Oreohelix Strigosa Delicata), Misty Nelson

Institute for Natural Resources Publications

Oregon state conservation status assessment for Blue mountainsnail (Oreohelix strigosa delicata) using NatureServe methodology, 2023.

Loss Of Cftr Function In Macrophages Alters The Cell Transcriptional Program And Delays Lung Resolution Of Inflammation, Dianne Wellems, Yawen Hu, Scott Jennings, Guoshun Wang

School of Graduate Studies Faculty Publications

Cystic fibrosis (CF) is an autosomal recessive genetic disorder caused by mutations in the CF Transmembrane-conductance Regulator (CFTR) gene. The most severe pathologies of CF occur in the lung, manifesting as chronic bacterial infection, persistent neutrophilic inflammation, and mucopurulent airway obstruction. Despite increasing knowledge of the CF primary defect and the resulting clinical sequelae, the relationship between the CFTR loss of function and the neutrophilic inflammation remains incompletely understood. Here, we report that loss of CFTR function in macrophages causes extended lung inflammation. After intratracheal inoculation with Pseudomonas aeruginosa, mice with a macrophage-specific Cftr-knockout (Mac-CF) were able to mount an …

Historical Kinship And Categorical Mischief: The Use And Misuse Of Doctrinal Borrowing In Intellectual Property Law, Mark Bartholomew, John Tehranian

Journal Articles

Analogies are ubiquitous in legal reasoning, and, in copyright jurisprudence, courts frequently turn to patent law for guidance. From introducing doctrines meant to regulate online intermediaries to evaluating the constitutionality of resurrecting copyrights to works from the public domain, judges turn to patent law analogies to lend ballast to their decisions. At other times, however, patent analogies with copyright law are quickly discarded and differences between the two regimes highlighted. Why? In examining the transplantation of doctrinal frameworks from one intellectual property field to another, this Article assesses the circumstances in which courts engage in doctrinal borrowing, discerns their rationale …

Oregon State Rank Assessment For Columbia Sideband (Monadena Fidelis Columbiana), Eleanor P. Gaines, Misty Nelson

Institute for Natural Resources Publications

Oregon state conservation status assessment for Columbia sideband (Monadenia fidelis columbiana) using NatureServe methodology, 2023.

Enzyme Kinetics Of Deoxyuridine Triphosphatase From Western Corn Rootworm, Carlos Riera‑Ruiz, Hideaki Moriyama

School of Biological Sciences: Faculty Publications

Objective The Western corn rootworm (WCR), Diabrotica virgifera virgifera, is a highly adaptable insect pest that has evolved resistance to a variety of control strategies, including insecticides. Therefore, it is interesting to examine how housekeeping proteins in WCR have been changed under WCR-controlling strategies. In this study, we focused on one of such proteins in WCR, a ubiquitous enzyme 5’-triphosphate nucleotidohydrolase (dUTPase). In the thymidine synthetic pathway, dUTPase hydrolyzes deoxyuridine triphosphate (dUTP) and supplies the substrate, deoxyuridine monophosphate, for the thymidylate synthase (TS). It decreases the cellular content of uracil, reducing uracil misincorporation into DNA. Suppressing the dUTPase activity, …

Enzyme Kinetics Of Deoxyuridine Triphosphatase From Western Corn Rootworm, Carlos Riera‑Ruiz, Hideaki Moriyama

School of Biological Sciences: Faculty Publications

Objective The Western corn rootworm (WCR), Diabrotica virgifera virgifera, is a highly adaptable insect pest that has evolved resistance to a variety of control strategies, including insecticides. Therefore, it is interesting to examine how housekeeping proteins in WCR have been changed under WCR-controlling strategies. In this study, we focused on one of such proteins in WCR, a ubiquitous enzyme 5’-triphosphate nucleotidohydrolase (dUTPase). In the thymidine synthetic pathway, dUTPase hydrolyzes deoxyuridine triphosphate (dUTP) and supplies the substrate, deoxyuridine monophosphate, for the thymidylate synthase (TS). It decreases the cellular content of uracil, reducing uracil misincorporation into DNA. Suppressing the dUTPase activity, …

Candida Auris-Macrophage Cellular Interactions And Transcriptional Response, Pedro Miramón, Andrew W Pountain, Michael C Lorenz

Faculty, Staff and Student Publications

The pathogenic yeast Candida auris represents a global threat of the utmost clinical relevance. This emerging fungal species is remarkable in its resistance to commonly used antifungal agents and its persistence in the nosocomial settings. The innate immune system is one the first lines of defense preventing the dissemination of pathogens in the host. C. auris is susceptible to circulating phagocytes, and understanding the molecular details of these interactions may suggest routes to improved therapies. In this work, we examined the interactions of this yeast with macrophages. We found that macrophages avidly phagocytose C. auris; however, intracellular replication is …

Lahu Immigrants' Attitudes Toward Seeking Mental Health, Nulek Singkeovilay

Walden Dissertations and Doctoral Studies

No abstract provided.

Role Of The Glutamine-Polyamine-Hypusine Axis In Cd8+ T Cell Fate And Function, Aya Gamal Aly Sadek Elmarsafawi

USF Tampa Graduate Theses and Dissertations

T cells are critical effectors of the immune response against pathogens and malignancies and, given the recent success of T-cell immunotherapies in cancer, there is now an urgent need to enhance the efficacy and durability of T-cell immune responses to improve anti-tumor immunity. Formation of memory T cells is a critical step of a successful immune response as it ensures maintenance of long-term immunity and protection from re-exposure to foreign antigens. Notably, metabolism regulates the fate and function of T cells and is a powerful tool to modulate T-cell activity and memory differentiation. Accordingly, metabolic interventions to augment T-cell memory …

Tami Spry: The Force Of (Co-)Performing, Ken Gale, Jonathan Wyatt

Plymouth Institute of Education

In this short article, we work with the notion of Tami Spry as force. There is a tension here: We have come to recognize, both through the writing of this article and through our many years of encountering both Tami herself and Tami’s work as performer and writer, how we find ourselves needing to de-personalize and de-individualize: we are drawn into the beyond, the uncontainable, the “more-than,” of Tami and Tami’s work. At the same time as this impulse to de-personalize and de-individualize, we recognize—and cherish—that Tami Spry’s work could not happen without Tami Spry. We experience, and seek to …

Kenyon Collegian - November 16, 2023

The Kenyon Collegian

No abstract provided.

Iron Deficiency In Pregnancy And Children, Brianna Kane, Stacy Bevan, Carrie Durward, Mateja R. Savoie-Roskos

All Current Publications

Meeting the proper iron recommendations is important for both children and mothers because iron is essential for growth and development. An inadequate intake of iron is the most common reason for iron deficiency. Eating appropriate amounts of iron during these stages of life is of upmost importance. Including sources of heme iron and vitamin C can help increase absorption of iron.

Oregon State Ranking Assessment For Harney Basin Duskysnail (Colligyrus Depressus), Misty Nelson

Institute for Natural Resources Publications

Oregon State Ranking Assessment for Harney Basin Duskysnail (Colligyrus depressus) by the Oregon Biodiversity Information Center, following NatureServe 2023 methodology.

Contribution Of Macrophages To Neural Survival And Intracochlear Tissue Remodeling Responses Following Cochlear Implantation, Muhammad Taifur Rahman, Brian J Mostaert, Bryce Hunger, Utsow Saha, Alexander D Claussen, Ibrahim Razu, Farjana Nasrin, Nashwaan Ali Khan, Peter Eckard, Sarah Coleman, Jacob Oleson, Jonathon R Kirk, Keiko Hirose, Marlan R Hansen

2020-Current year OA Pubs

BACKGROUND: Cochlear implants (CIs) restore hearing to deafened patients. The foreign body response (FBR) following cochlear implantation (post-CI) comprises an infiltration of macrophages, other immune and non-immune cells, and fibrosis into the scala tympani, a space that is normally devoid of cells. This FBR is associated with negative effects on CI outcomes including increased electrode impedances and loss of residual acoustic hearing. This study investigates the extent to which macrophage depletion by an orally administered CSF-1R specific kinase (c-FMS) inhibitor, PLX-5622, modulates the tissue response to CI and neural health.

MAIN TEXT: 10- to 12-week-old CX3CR1 + /GFP Thy1 + …

Wagon Tracks Volume 38, Issue 1 (Nov 2023)

Wagon Tracks

Contents

2 On the Cover: The View from Wagon Mound: Jackie Fleming

4 Trail Writings: Chris Day

5 Joanne’s Jottings

6 News along the Trail

7-11 Tributes to Marc Simmons

12-13 The Caches: Joanne VanCoevern and Leo Oliva

14 SFTA Awards

15-20 Santa Fe Trail Association Hall of Fame

21-27 Hell on Wheels: El Moro,Trinidad, and Oteroby Dr. Michael L. Olsen

27 SFTA Action Items

28 Chapter Reports

29 Membership Form

32 Calendar

Charting The Choppy Waters: Navigating Maritime Disputes In The South China Sea, Abby Barnes, Madeline Cewe, Kate Gibson, Cait Kelley

Ohio Northern University International Law Journal

In January of 2022, the United States Department of State concluded in their Limits in the Seas study that the People’s Republic of China (PRC) has asserted unlawful maritime claims in the majority of the South China Sea.1 n Limits in the Seas, the United States called on the PRC once again to “conform its maritime claims to international law and to cease its unlawful and coercive activities in the South China Sea.”2 While the legal basis for China’s claims is hotly contested, this article seeks to navigate such unlawful and coercive activities in the region by detailing the history, …