Digital Commons Network^™

Cortisol And Epinephrine Alter The Adipose Functions And The Mobilization Of Pcbs In Adipose Tissue Slices From Elephant Seal, Laura Pirard, Jane I. Khudyakov, Daniel E. Crocker, Liesbeth Van Hassel, Georges Scholl, Gauthier Eppe, Melissa M. Page, Jean-François Rees, Donald R. Smith, Cathy Debier

Pacific Faculty Work

Marine mammals are exposed to increasing intensities of anthropogenic stressors such as acoustic disturbance and contaminants. Correlative studies have suggested concerning shifts in behavioral and physiological status of stress-exposed individuals, which could alter the health and survival of marine mammal populations. However, functional studies of the effects of multiple stressors on marine mammals are lacking. To fill in this gap, we recently developed an ex vivo approach of precision-cut adipose tissue slices (PCATS) to study the impact of stressors on the function of an essential endocrine organ: the adipose tissue. In the present study, we investigated the impact of hormones …

Seven Recipes To Save Yourself, Megan Bachman

B.F.A. Practicum Exhibition (ART 498)

Food is an undeniable constant. Food can be a declaration of love, gratitude, or wealth. It can be a reflection of individuals, as well as communities. The relationship between a person (or character) and food can speak volumes to the audience about who they are and how they interact with the artist's world. I am inspired by the works of Domee Shi (Director behind Bao and Turning Red) and Hayao Miyazaki (Director behind Studio Ghibli). They use food to further their narrative, and do so with enticing colors, textures, and sounds. That is why I chose to create posters …

Accessibility Or Environmental Conservation? Evaluating The Relationship Between Environmental Protection And Hiking Trails Accessibility Via Lidar & Remote Sensing, Zhanchao Yang

GIS Day

Binghamton University Nature Preserve spans 190 acres of land, with a notable 20-acre wetland serving a multifaceted purpose. It is dedicated to preserving the ecological integrity of this landscape, fostering biodiversity, and facilitating research and environmental education. Furthermore, it serves as a recreational space for students, enhancing the bonds between the campus and the neighboring community. This research focuses on Binghamton University's nature preserve as a case study to explore the intricate balance between two vital objectives: ensuring equal access for all user demographics while safeguarding its ecosystem services. To achieve these objectives, the study employs diverse public engagement methods, …

Sustainability And Circular Economy Horizon Scan And Needs Analysis, Sadaf Dalirazar, Mark Kelly, Derek Sinnott, James O'Donnell

Reports

The construction industry plays a crucial role in addressing the climate crisis as it is the largest global consumer of raw materials and contributes significantly to global energy consumption and emissions. Considering the world’s continuous population growth and the imperative to address infrastructure and housing demands the construction sector needs to adopt further sustainable strategies in its activities to reduce the pressure on natural resources. In addition, the Architecture, Engineering, and Construction (AEC) sector is responsible for generating substantial amount of waste known as Construction and Demolition Waste (CDW), which is projected to increase due to the future construction developments. …

Channel Catfish (Ictalurus Punctatus), Neurocranium, Corinne Renshaw, Brianna Buckley, David Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

Neurocranium from 4.9 cm total length 20.6 cm Ictalurus punctatus (Channel Catfish), collected from Dr. Kerstetter's dissection specimens.

In Yellow: A Solo Poem-Play, Emily Kitchens

Faculty Articles

“In Yellow” was developed in the INKubator residency at Art House Productions (Jersey City, NJ) in 2019 with the following blurb:

In Yellow is a solo poem-play about a relationship between a young woman and a ceramic doll her grandmother made that she has just accidentally broken. It is about grief. It is about breaking out of generationally instilled feminine values. It is about the color yellow. It’s all true.

“In Yellow” is an experiment of a poem and play for one voice. I was in New York City for about 10 years, before that The Bay Area, but am …

Dynamics Of Cwd Prion Detection In Feces And Blood From Naturally Infected White-Tailed Deer, Francisca Bravo-Risi, Paulina Soto, Rebeca Benavente, Tracy A Nichols, Rodrigo Morales

Faculty, Staff and Student Publications

Chronic wasting disease (CWD) is a prion disease affecting cervids. Confirmatory testing of CWD is currently performed postmortem in obex and lymphoid tissues. Extensive evidence demonstrates the presence of infectious prions in feces of CWD-infected deer using in vitro prion-amplification techniques and bioassays. In experimental conditions, this has been achieved as soon as 6-month post-inoculation, suggesting this sample type is a candidate for antemortem diagnosis. In the present study, we optimized the detection of CWD-prions in fecal samples from naturally infected, pre-clinical white-tailed deer by comparing protocols aiming to concentrate CWD-prions with direct spiking of the sample into the PMCA …

Revisiting The Use Of Normal Saline For Peritoneal Washing In Ovarian Cancer, Hironari Akasaka, Honami Naora

Faculty, Staff and Student Publications

The omentum is the predominant site of ovarian cancer metastasis, but it is difficult to remove the omentum in its entirety. There is a critical need for effective approaches that minimize the risk of colonization of preserved omental tissues by occult cancer cells. Normal saline (0.9% sodium chloride) is commonly used to wash the peritoneal cavity during ovarian cancer surgery. The omentum has a prodigious ability to absorb fluid in the peritoneal cavity, but the impact of normal saline on the omentum is poorly understood. In this review article, we discuss why normal saline is not a biocompatible solution, drawing …

Evaluating The Contamination By Indoor Dust In Dubai, Yousef Nazzal, Alina Bărbulescu, Manish Sharma, Fares Howari, Muhammad Naseem

All Works

Nowadays, people spend most of their time indoors. Despite constantly cleaning these spaces, dust apparition cannot be avoided. Since dust can contain chemical elements that negatively impact people's health, we propose the analysis of the metals from the indoor dust component collected in different locations in Dubai, UAE. Multivariate statistics (correlation matrix, clustering) and quality indicators (QI)-Igeo, PI, EF, PLI, Nemerow-were used to assess the contamination level with different metals in the dust. We proposed two new QIs (CPI and AQI) and compared the results with those provided by the most used indices-PLI and Nemerow. It is shown that high …

Blood-Based Proteomic Signatures Associated With Men1-Related Duodenopancreatic Neuroendocrine Tumor Progression, Johannes F Fahrmann, Amanda R Wasylishen, Carolina R C Pieterman, Ehsan Irajizad, Jody Vykoukal, Ranran Wu, Jennifer B Dennison, Christine B Peterson, Hua Zhao, Kim-Anh Do, Daniel M Halperin, Sunita K Agarwal, Jenny E Blau, Smita Jha, Jaydira Del Rivero, Naris Nilubol, Mary F Walter, James M Welch, Lee S Weinstein, Menno R Vriens, Rachel S Van Leeuwaarde, Mark J C Van Treijen, Gerlof D Valk, Nancy D Perrier, Samir M Hanash, Hiroyuki Katayama

Faculty, Staff and Student Publications

PURPOSE: Patients with multiple endocrine neoplasia type 1 (MEN1) are predisposed to develop duodenopancreatic neuroendocrine tumors (dpNETs), and metastatic dpNET is the primary cause of disease-related mortality. Presently, there is a paucity of prognostic factors that can reliably identify patients with MEN1-related dpNETS who are at high risk of distant metastasis. In the current study, we aimed to establish novel circulating molecular protein signatures associated with disease progression.

EXPERIMENTAL DESIGN: Mass spectrometry-based proteomic profiling was conducted on plasmas procured through an international collaboration between MD Anderson Cancer Center, the National Institutes of Health, and the University Medical Center Utrecht from …

Mechanisms Of Endothelial Cell Membrane Repair: Progress And Perspectives., Duoduo Zha, Shizhen Wang, Paula Monaghan-Nichols, Yisong Qian, Venkatesh Sampath, Mingui Fu

Manuscripts, Articles, Book Chapters and Other Papers

Endothelial cells are the crucial inner lining of blood vessels, which are pivotal in vascular homeostasis and integrity. However, these cells are perpetually subjected to a myriad of mechanical, chemical, and biological stresses that can compromise their plasma membranes. A sophisticated repair system involving key molecules, such as calcium, annexins, dysferlin, and MG53, is essential for maintaining endothelial viability. These components orchestrate complex mechanisms, including exocytosis and endocytosis, to repair membrane disruptions. Dysfunctions in this repair machinery, often exacerbated by aging, are linked to endothelial cell death, subsequently contributing to the onset of atherosclerosis and the progression of cardiovascular diseases …

Lived Experiences Of Counselors: Navigating The Changing Role Using Emotional Intelligence, Marissa Joelle Stelzer

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to describe the lived experiences of counselors during the transition from traditional face-to-face counseling to a teletherapy format during the COVID-19 pandemic and how counselors were able to utilize emotional intelligence skills/abilities during this time. The theories that guided this study were the ability model of emotional intelligence and social constructivism. The following questions guided this study: How did counselors experience their changing role from primarily face-to-face counseling to teletherapy during the COVID-19 pandemic? How did counselors experience emotional intelligence during the transition from traditional face-to-face counseling to teletherapy during the COVID-19 pandemic? …

Erosion Of Credibility: A Mixed Methods Evaluation Of Twitter News Headlines From The New York Times, Washington Post, Wall Street Journal, Los Angeles Times, And Usa Today, Melinda M. Skrbin

Doctoral Dissertations and Projects

To entice and commodify social media news consumers, contemporary news organizations have increasingly relied on data analytics to boost audience engagement. Clicks, likes, and shares are the metrics that now guide the editorial process and shape decisions about content and coverage. As such, news headlines are regularly manipulated to attract the attention of those who quickly scroll through social media networks on computers and smartphones. However, few studies have examined the typologies of news content most likely to be manipulated in social media news headlines or the impact of news headline manipulation on news source credibility. For this research, source …

Unmerited Inheritance: An Exposition Of The Twelve Divine Elements, Fulfillment, And Typology Of Yahweh’S Tithe To Levi, Noble Sokolosky

Doctoral Dissertations and Projects

This dissertation seeks to advance the academy’s conversation about the Mosaic tithe ordinance by providing the first published reconciliation of what many scholars consider irreconcilable statutes. It does so by providing the first published exposition of the twelve divine elements of Yahweh’s sacred tithe against the land sabbatical and Jubilee statutes. Unless scholars can agree upon its divine elements, there is little hope for unity and progress towards edifying the saints with the typology of Yahweh’s inheritance tithe to Levi (Num 18:26).

A Multi-Case Study Of Church-Based Business Leader Discipleship Programs And The Furtherance Of The Gospel, Robert Cross

Doctoral Dissertations and Projects

Can ministry and business be integrated within the church so there can be a positive impact in the church and community by business leaders understanding their unique calling in furthering the gospel? This descriptive qualitative multi-case research explored whether business and ministry can be integrated through a church-based business leader discipleship programs that will result in the furthering and sharing of the gospel. Churches with a discipleship program specifically for business leaders in the church and the business leaders who participated in the programs were interviewed to determine if there is a correlation between participating in a discipleship program and …

The Therapeutic Church, Isidro Morell

Doctoral Dissertations and Projects

This project aims to develop Nexus Point Church as a therapeutic environment. The Therapeutic Church environment is a supportive community, one member to another, ministering to each other empathetically, not service dependent or a dispenser of services. It is “Pew Neighbor” supportive and crisis intervention ready. The Therapeutic Church provides a therapeutic environment that heals interactively in spirit, mind, body, and relationship to improve the quality of life for the church member and those seeking help. This project identifies members as “Pew Neighbors” due to the proximity and continual closeness shared with those within the church community. Pew neighbors serve …

Dlx2 Promotes Osteosarcoma Epithelial-Mesenchymal Transition And Doxorubicin Resistance By Enhancing Hoxc8-Cdh2 Axis, Boya Zhang, Xinhui Du, Yichao Fan, Guoxin Qu, Lon Kai Pang, Ruiying Zhao, Weitao Yao

Faculty, Staff and Student Publications

Metastasis and doxorubicin resistance are challenges in the clinical diagnosis and treatment of osteosarcoma, the mechanisms underlying these phenomena remain unclear. In this study, we found that DLX2 is highly expressed in metastatic osteosarcoma and is closely related to clinical prognosis. Knockdown of DLX2 inhibited tumor proliferation and migration in vitro and inhibited tumor growth in vivo. Mechanistically, we found that DLX2 enhanced the repression of CDH2 transcription by binding to HOXC8, thereby promoting the epithelial-mesenchymal transition in osteosarcoma cells. Through subsequent exploration, we found that targeting DLX2/HOXC8 signaling significantly restores the sensitivity of osteosarcoma cells to doxorubicin. In …

Autumn String Orchestra Concert: "Reflections Of The American Spirit" (2023), St. Norbert College Music Department

Music Performances

SNC Music Department presents: the Autumn String Orchestra Concert & the "Reflections of the American Spirit," featuring the music of Charles Lloyd Jr (2023).

Pmca Screening Of Retropharyngeal Lymph Nodes In White-Tailed Deer And Comparisons With Elisa And Ihc, Rebeca Benavente, J Hunter Reed, Mitch Lockwood, Rodrigo Morales

Faculty, Staff and Student Publications

Chronic wasting disease (CWD) is a prion disease affecting cervids. CWD diagnosis is conducted through enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry (IHC) in retropharyngeal lymph nodes. Unfortunately, these techniques have limited sensitivity against the biomarker (CWD-prions). Two in vitro prion amplification techniques, real-time quaking-induced conversion (RT-QuIC) and protein misfolding cyclic amplification (PMCA), have shown promise in detecting CWD-prions in tissues and bodily fluids. Recent studies have demonstrated that RT-QuIC yields similar results compared to ELISA and IHC. Here, we analyzed 1003 retropharyngeal lymph nodes (RPLNs) from Texas white-tailed deer. PMCA detected CWD at a higher rate compared to ELISA/IHC, identified …

A Snapshot Into The Lives Of Elephants: Camera Traps And Conservation In Etosha National Park, Namibia, Jodie L. Berezin, Amanda J. Odom, Virginia Hayssen, Caitlin E. O'Connell-Rodwell

Biological Sciences: Faculty Publications

Knowledge of elephant movement and grouping patterns in the wild is critical for their management and conservation. Much of these data come from GPS collar data and aerial surveys, which have provided invaluable information, but data from these methods are often limited to small groups or entire populations. Effective elephant management requires both generalized and localized methodologies. Here, we propose the expanded use of camera traps in research relating to elephant localized movements and grouping patterns as an additional tool for elephant conservation management. In this study, we use a battery-powered camera trap to provide daily high-resolution data of African …

Moving From Symptom Management To Upstream Plastics Prevention: The Fallacy Of Plastic Cleanup Technology, Melanie Bergmann, Hans Peter H. Arp, Bethanie Carney Almroth, Win Cowger, Marcus Eriksen, Tridibesh Dey, Sedat Gündoğdu, Rebecca R. Helm, Anja Krieger, Kristian Syberg, Mine B. Tekman, Richard C. Thompson, Patricia Villarrubia-Gómez, Anish Kumar Warrier, Trisia Farrelly

School of Biological and Marine Sciences

Plastic removal technologies can temporarily mitigate plastic accumulation at local scales, but evidence-based criteria are needed in policies to ensure that they are feasible and that ecological benefits outweigh the costs. To reduce plastic pollution efficiently and economically, policy should prioritize regulating and reducing upstream production rather than downstream pollution cleanup.

Keynote: Butting Heads And The Agency To Yield: Maverick Considerations In The Writing Center, Rebecca Hallman Martini

The Writing Center Journal

Despite their history of marginalization, writing centers need to be spaces where consultants, writers, and administrators act with agency. This requires both knowing when and how to act, as well as deciding when to yield. In challenging policies of seeming neutrality, I argue in this manuscript that writing center practitioners can center the needs and knowledge of consultants and writers alike. Finally, I call for more research about writer experiences with writing centers, which can (and should) meaningfully shape our administrative practices.

Keynote: Looking At Writing Centers Through Scientific Spectacles: The Expertise And Commitments That Characterize Contemporary Writing Centers, Bradley Hughes

The Writing Center Journal

This article is adapted from a keynote address at the July 2022 European Writing Centers Association (EWCA) conference, sponsored by the University of Graz in Austria, whose theme focused on writing centers as spaces of empowerment. Designed for peer tutors as well as writing center faculty, this talk first celebrates some examples of writing centers empowering student writers and tutors. It then attempts to articulate what scientific spectacles allow us to see when we look deeper into these examples of empowerment: some of the big ideas, the abstract principles, the constellation of expertise and commitments that underlie our contemporary writing …

The Perceptions And Lived Experiences Of African American Female Faculty At Predominantly White Institutions: A Phenomenological Study, Jasmine L. Jackson

Doctoral Dissertations and Projects

This qualitative phenomenological approach aims to understand the perceptions and lived experiences of African-American female faculty at predominantly White institutions and the strategies used to overcome barriers. The theory guiding this study is intersectionality theory, introduced by Kimberlè Crenshaw, discovering the multilayers of discrimination that women face and providing a template to encourage antidiscrimination. This theory adequately addresses the focus of this inquiry because it highlights the discrimination often experienced by African-American female faculty and the experiences of various individuals from the targeted population. This study's methodology was based on interviews with different African-American female faculty at predominantly White institutions. …

Oregon State Rank Assessment For Montane Peaclam (Pisidium Ultramontanum), Misty Nelson

Institute for Natural Resources Publications

Oregon State Rank Assessment for montane peaclam (Pisidium ultramontanum) using NatureServe methodology, 2023.

An Intersection Of Science & Art: Vitrification Approaches And Open-Fabricated Tools For The Biomedical Model Sea Hare, Aplysia Californica, Allyssa M. Oune

LSU Master's Theses

The California sea hare (Aplysia californica) is an important biomedical model for molecular neurobiology, electrophysiology, learning, and memory due to their well-mapped and large neurons and well-characterized learning capabilities. The National Resource for Aplysia (NRA, University of Miami) maintains large stocks of live animals and relies on regular shipments of wild-caught individuals to maintain genetic diversity. This is labor and cost-intensive, and environmental changes could alter the availability of wild animals increasing the need to preserve this genetic resource. One solution is vitrification, ultra-fast cooling which produces an amorphous glass that minimizes damage to cells. Aplysia californica presents …

Rbfox2 Regulated Eya3 Isoforms Partner With Six4 Or Zbtb1 To Control Transcription During Myogenesis, Hannah J Wiedner, R Eric Blue, Matheus Sadovsky, C Allie Mills, Xander H T Wehrens, Laura E Herring, Jimena Giudice

Faculty, Staff and Students Publications

Alternative splicing is a prevalent gene-regulatory mechanism, with over 95% of multi-exon human genes estimated to be alternatively spliced. Here, we describe a tissue-specific, developmentally regulated, highly conserved, and disease-associated alternative splicing event in exon 7 of the eyes absent homolog 3 (Eya3) gene. We discovered that EYA3 expression is vital to the proliferation and differentiation of myoblasts. Genome-wide transcriptomic analysis and mass spectrometry-based proteomic studies identified SIX homeobox 4 (SIX4) and zinc finger and BTB-domain containing 1 (ZBTB1), as major transcription factors that interact with EYA3 to dictate gene expression. EYA3 isoforms differentially regulate transcription, indicating that …

The Perceived Effectiveness Of Modular Theological Education In An International, Cross-Cultural Environment In Rwanda, Africa, Jonathan D. Mcginnis

Doctoral Dissertations and Projects

Theological education in an international, cross-cultural environment carries numerous obstacles. Challenges such as language, culture, and resources become overwhelming for the ministry striving to teach and train pastors overseas. Traditionally, establishing Bible schools, universities, and seminaries seemed to be a practical approach. Online education, though growing, is almost non-existent in most impoverished regions of the world. Both models bring challenges and beg the conversation about different options. In-person, modular theological education has been around for quite some time. Yet, there has been little to no research on the effectiveness of the approach to theological education in the international, cross-cultural environment. …

The Perspectives Of Ghanaian Political Leaders And Citizens Concerning The Development And Implementation Of The Ghana Vision 2020 Development Plan, Kwame Aduhene-Kwarteng

Doctoral Dissertations and Projects

The purpose of this qualitative research case study is to collect, investigate, and assess Ghanaian citizens’ and political leaders’ perspectives and viewpoints regarding the success or failure of Ghana Vision 2020 and the challenges facing developing nations. The study used a descriptive approach to examine Ghana’s Vision 2020 and the country’s development challenges using a descriptive methodology and primary and secondary sources. The 105 participants for the study included 65 males and 40 females living in Ghana. The theoretical framework of this study are modernization, globalization, and dependency theories. To that end, the study set out to investigate the question: …

Simulation Study Of A Novel Small Animal Flash Irradiator (Safi) With Integrated Inverse-Geometry Ct Based On Circularly Distributed Kv X-Ray Sources, Yuewen Tan, Shuang Zhou, Jonathan Haefner, Qinghao Chen, Thomas R Mazur, Arash Darafsheh, Tiezhi Zhang

2020-Current year OA Pubs

Ultra-high dose rate (UHDR) radiotherapy (RT) or FLASH-RT can potentially reduce normal tissue toxicity. A small animal irradiator that can deliver FLASH-RT treatments similar to clinical RT treatments is needed for pre-clinical studies of FLASH-RT. We designed and simulated a novel small animal FLASH irradiator (SAFI) based on distributed x-ray source technology. The SAFI system comprises a distributed x-ray source with 51 focal spots equally distributed on a 20 cm diameter ring, which are used for both FLASH-RT and onboard micro-CT imaging. Monte Carlo simulation was performed to estimate the dosimetric characteristics of the SAFI treatment beams. The maximum dose …