Digital Commons Network^™

Metagenomic Analysis Unveils The Microbial Landscape Of Pancreatic Tumors, Sheema Khan, Goutam Banerjee, Saini Setua, Daleniece Jones, Bhavin Chauhan, Anupam Dhasmana, Pratik Banerjee, Murali M. Yallapu, Stephen Behrman, Subhash C. Chuahan

School of Medicine Publications

The composition of resident microbes in the human body is linked to various diseases and their treatment outcomes. Although studies have identified pancreatic ductal adenocarcinoma (PDAC)-associated bacterial communities in the oral and gut samples, herein, we hypothesize that the prevalence of microbiota in pancreatic tumor tissues is different as compared with their matched adjacent, histologically normal appearing tissues, and these microbial molecular signatures can be highly useful for PDAC diagnosis/prognosis. In this study, we performed comparative profiling of bacterial populations in pancreatic tumors and their respective adjacent normal tissues using 16S rRNA-based metagenomics analysis. This study revealed a higher abundance …

Combination Of Thymoquinone And Intermittent Fasting As A Treatment For Breast Cancer Implanted In Mice, Shatha Khaled Haif, Lina T. Al Kury, Wamidh H. Talib

All Works

Breast cancer stands out as a particularly challenging form of cancer to treat among various types. Traditional treatment methods have been longstanding approaches, yet their efficacy has diminished over time owing to heightened toxicity, adverse effects, and the emergence of multi-drug resistance. Nevertheless, a viable solution has emerged through the adoption of a complementary treatment strategy utilizing natural substances and the incorporation of intermittent fasting to enhance therapeutic outcomes. This study aimed to assess the anticancer activity of thymoquinone (TQ), intermittent fasting, and their combination using in vivo and in vitro methods. The anti-proliferative activity of TQ and fasting (glucose/serum …

Metalloproteomic Investigation Of Hg-Binding Proteins In Renal Tissue Of Rats Exposed To Mercury Chloride, Emerson Carlos De Almeida, Victor Diego Faria, Felipe Dalmazzo Cirinêu, Maria G.A. Santiago, Beatriz Miotto, José C.S. Vieira, Camila Pereira Braga, Jiri Adamec, Ana A.H. Fernandes, Marília A.R. Buzalaf, Pedro De Magalhães Padilha

School of Medicine Faculty Publications

Results obtained from rat studies indicate that, even at low concentrations, mercurial species cause harmful effects on the kidneys, by inducing the nephrotic oxidative stress response. In the present work, Hg-associated proteins were identified as possible mercury-exposure biomarkers in rat kidneys exposed to low mercury chloride concentrations for 30 days (Hg-30) and 60 days (Hg-60), using metalloproteomic strategies. The renal proteomic profile was fractioned by two-dimensional electrophoresis and the mercury determinations in kidney samples, protein pellets and protein spots were performed using graphite furnace atomic absorption spectrometry. The characterization of Hg-associated protein spots and the analysis of differentially expressed proteins …

You Can Lead A Horse To Water: Mapping Seasonal Water Resources To Predict Wild Horse Movements On Utah Rangelands, David C. Stoner, Eric Thacker, Linden Greenhalgh, Mark Nelson

All Current Publications

All wild horse herd management areas in Utah overlap BLM grazing allotments. Although horses and cattle have similar dietary habits, both species rely heavily on predictable water sources during dry periods. The concentration of wildlife and livestock in mesic areas during droughts can become problems for farmers and livestock producers. We aimed to map the annual distribution of temporary surface water across Utah that cattle, horses, and wildlife could use. Herein we analyzed an 18-year record of satellite imagery to create a statewide map of seasonal surface-water availability for agricultural and wildlife management purposes.

Ints6 And The Integrator Phosphatase Module Tune The Efficiency Of Select Premature Transcription Termination Events, Rina Fujiwara, Si-Nan Zhai, Dongming Liang, Aayushi P Shah, Matthew Tracey, Xu-Kai Ma, Christopher J Fields, María Saraí Mendoza-Figueroa, Michele C Meline, Deirdre C Tatomer, Li Yang, Jeremy E Wilusz

Children’s Nutrition Research Center Staff Publications

The metazoan-specific Integrator complex catalyzes 3' end processing of small nuclear RNAs (snRNAs) and premature termination that attenuates the transcription of many protein-coding genes. Integrator has RNA endonuclease and protein phosphatase activities, but it remains unclear if both are required for complex function. Here, we show IntS6 (Integrator subunit 6) over-expression blocks Integrator function at a subset of Drosophila protein-coding genes, although having no effect on snRNAs or attenuation of other loci. Over-expressed IntS6 titrates protein phosphatase 2A (PP2A) subunits, thereby only affecting gene loci where phosphatase activity is necessary for Integrator function. IntS6 functions analogous to a PP2A regulatory …

Distinct Gene Expression Signatures Comparing Latent Tuberculosis Infection With Different Routes Of Bacillus Calmette-Guérin Vaccination, Richard F Silver, Mei Xia, Chad E Storer, Jessica R Jarvela, Michelle C Moyer, Azra Blazevic, David A Stoeckel, Erin K Rakey, Jan M Tennant, Johannes B Goll, Richard D Head, Daniel F Hoft

2020-Current year OA Pubs

Tuberculosis remains an international health threat partly because of limited protection from pulmonary tuberculosis provided by standard intradermal vaccination with Bacillus of Calmette and Guérin (BCG); this may reflect the inability of intradermal vaccination to optimally induce pulmonary immunity. In contrast, respiratory Mycobacterium tuberculosis infection usually results in the immune-mediated bacillary containment of latent tuberculosis infection (LTBI). Here we present RNA-Seq-based assessments of systemic and pulmonary immune cells from LTBI participants and recipients of intradermal and oral BCG. LTBI individuals uniquely display ongoing immune activation and robust CD4 T cell recall responses in blood and lung. Intradermal BCG is associated …

Engaging Community Partners To Enrich Preschoolers Learning Experiences With Dramatic Inquiry, Kathleen M. Farrand, Wendy Peia Oakes, Megan Troxel Deeg, Katelyn Jaworksi, Veronica Leon

Journal of the Arts and Special Education

Interdisciplinary teams of adults are needed to enhance the capacity of schools to provide the most appropriate educational experiences for young children who have or are at risk for developmental delays and disabilities (Division for Early Childhood, 2014). When educators, families, and community partners connect around shared goals, we begin to reimagine instructional opportunities and create more equitable access to educational resources for children and families. We share insights from community partners who participated in a collaborative dramatic inquiry study designed to enrich preschoolers’ learning experiences and serve children and families.

Culturally Sustaining Math Word Problem Instruction With Hip-Hop Story Schemas, Michelle J. Cook, Jonte C. Taylor, Elizabeth M. Hughes, Thomas D. Deau

Journal of the Arts and Special Education

On August 11, 2023, Hip-Hop celebrated its 50^th anniversary. In honor of this milestone, we share an activity that is designed to harness the power and art of Hip-Hop to support learning in mathematics for students with and without exceptionalities. Using a vignette, we examine why culturally sustaining practices are pivotal to learning and how teachers can collaborate with middle-school students to strengthen an evidence-based practice such as schema-based instruction by honoring the funds of knowledge that students possess. The activity includes (a) the creation of culturally relevant word problems in mathematics, (b) schema-based instruction for solving additive-type word …

"Being On God’S Side": Biblical Leaders On Wokeness, Social Justice, Cancel Culture, White Privilege, And Other Controversial Terms, Hershey H. Friedman, Svetlana Vlady

The Journal of Values-Based Leadership

Terms such as “woke,” “social justice,” “cancel culture,” “identity politics,” “politically correct,” “critical race theory,” and “DEI” have been increasingly misused and politicized by both the left and the right in recent years. This paper will examine the Hebrew Bible and explore what it says about social justice, compassion for the indigent, inclusion, and many other terms causing such an uproar. The authors assert that the ancient prophets, the true social justice warriors, would be horrified by the actions of both the left and right.

Humanity As Community: A Prescription For The Ethically Possible, Joseph P. Hester

The Journal of Values-Based Leadership

No abstract provided.

Teaching Critical Race Media Literacy Through Black Historical Narratives, Christine Mcwhorter, Tiffany Mitchell Patterson

Journal of Media Literacy Education

On the 400th anniversary of American enslavement the New York Times (NYT) 1619 project launched an interactive digital experience including a popular podcast centering the contributions and narratives of Black Americans. This study sought to understand how HBCU students responded to learning Black music history through what we term a “pop culture podcast.” This study explored the ways in which this particular podcast could support the development of Critical Race Media Literacy (CRML) based on a media discourse at a Historically Black College/University (HBCU). This study employed survey research and focus group discussions with HBCU students in two courses. The …

The Complexities Of Green Infrastructure, Troy Weber

Purdue Journal of Service-Learning and International Engagement

The Wabash River is the most extensive river system in Indiana. The river drains two-thirds of Indiana’s 92 counties, which can have issues associated with stormwater runoff (Weist, 1981). As precipitation runs off impervious surfaces, it can carry high concentrations of pollutants, such as excess nitrogen and phosphorus, pet waste, and automobile fuel. Prior to impervious runoff entering the river, preexisting contaminants include industrial waste (acid mine drainage and oil field brines), municipal waste, and sediment (Weist, 1981). Thus, stormwater runoff can negatively impact the Wabash River watershed. On top of this pollution, Lafayette and West Lafayette have combined sewer …

دور استراتيجيات التحول الرقمي للحوكمة في تعزيز الريادة الرقمية في جامعة الشرق األوسط من وجهة نظر أعضاء الهيئة التدريسية, Ramzi Mubarak Al-Tarawneh, Sahar Mohammad Al-Tarawneh

Journal of the Association of Arab Universities for Research in Higher Education مجلة اتحاد الجامعات العربية للبحوث في التعليم العالي

هدف المقال التعرف إلى دور إستراتيجيات التحول الرقمي للحوكمة في تعزيز الريادة الرقمية في جامعة الشرق األوسط، من وجهة نظر أعضاء هيئة التدريس،واتبعت الدراسة المنهج الوصفي التحليلي، حيث إستهدفت جميع أعضاء الهيئة التدريسية والبالغ عددهم )204( عضواً تدريسيا واستخدمت العينة العشوائية البسيطة وحجمها ،ً )154( عضوا، ا ُعتمدت اإلستبانة كأداة لجمع البيانات وتحليلها بإستخدام التحليل العاملي اإلستكشافي، واألوساط الحسابية واإلنحرافات المعيارية، واختبار ) T ) واألساليب اإلحصائية المناسبة لتحقيق أهداف الدراسة والتوصل لنتائجها . كانت أهم نتائج الدراسة أن درجة تطبيق استراتيجيات التحول الرقمي للحوكمة في جامعة الشرق األوسط جاءت بمرتبة عالية من التقدير، ومستوى تعزيزالريادة الرقمية جاء بدرجة عالية، …

Environmental Footmark And Its Effects On The Sustainability Of Towns, Ali Abdul Samea Hameed

Al-Esraa University College Journal for Engineering Sciences

The Ecological Footmark (EF) is one of the utmost recent and important criteria for assessing the capacity of the population to uphold a life sustainable way. It tests the extent which the indicators have an influence on the natural resources (NR) of the ecosystem such as forestry, water bodies, agricultural lands, pastures, CO2, and properties for construction purposes. This footmark was utilized to evaluate the use of NR to the capacity of the land for regeneration. This research paper discusses the theoretical conceptual component of the EF framework and plans regarding issues related to the environment. The environmental image (EI) …

Some Biological Markers In Diabetic Patients, Ahmed Malk Hassan, Hasan Ali Hussein, Radhwan Mohmmed Hussein, Maryam Hiyder Kadhum

Al-Esraa University College Journal for Medical Sciences

Endstage renal disease (ESRD) usually comes on by diabetic nephropathy (DN) and is one of the most dreaded chronic microvascular complications of diabetes. The objective of this study is to provide an overview of the DN-biomarker landscape with a particular emphasis on new approaches that improve the sensitivity of biomarkers for identifying patients who will develop DN or who are at risk of developing ESRD. This study was designed as a case-control study. 120 individuals were involved, divided into three groups: a control group diabetic without nephropathy, Early stage and end stage of nephropathy, 40 patients were taken for each …

Interminables Encrucijadas: El Dilema Ético En Tomás Nevinson, Isabel Cuñado

Faculty Journal Articles

La muerte de Javier Marías en 2022 ha convertido de manera fortuita Tomás Nevinson (2021) en el colofón de una extraordinaria trayectoria literaria que cumplía cincuenta años con esta novela. Es posible apreciar en ella la culminación de los grandes ejes de pensamiento que se han venido desarrollando a lo largo de décadas en esta obra, más característica por dejar preguntas abiertas que por proponer respuestas. Las preocupaciones epistemológicas en torno a la crisis referencial del lenguaje emergen de nuevo aquí y entroncan con la segunda cuestión clave de esta narrativa: la ética. En este artículo propongo que el dilema …

“Too Pretty To Be Brain Injured” Dance Movement Therapy And Women With/Recovering From Traumatic Brain Injury: A Literature Review, Cathy Patricia Hall

Expressive Therapies Capstone Theses

The objective of this literature aims to first, elucidate the history of the exclusion or absence of women in research examining traumatic brain injury (TBI). Second, in reviewing more recent published research examining women and traumatic brain injury, trends indicate women are prone to injury at increasing rates to men, due to biological sex, physiological makeup, and different etiologies. Finally, this literature review endeavors to examine published dance/movement therapy (DMT) research, and recommendations, for suggested interventions to apply to women with traumatic brain injuries and common comorbid diagnosis of depression, and PTS. Unique challenges this population experiences. In doing so …

A Novel Approach For Solving Neutrosophic Fractional Transportation Problem With Non- Linear Discounting Cost, Hamiden Abd El-Wahed Khalifa, Said Broumi, S. A. Edalatpanah, Alhanouf Alburaikan

Neutrosophic Sets and Systems

No abstract provided.

Tfeb Degradation Is Regulated By An Ikk/Β-Trcp2 Phosphorylation-Ubiquitination Cascade, Yan Xiong

Arts & Sciences Graduate Student Theses and Dissertations

Transcription factor EB (TFEB) is a master regulator of lysosomal biogenesis and autophagy that plays a key role in the regulation of cellular clearance pathways. TFEB is regulated via a complex array of post-translational modifications (PTMs), but the exact molecular mechanism that regulates TFEB stability has remained elusive. Here, we show that TFEB levels are critically regulated by a defined phosphorylation-ubiquitination cascade. A human kinome screen identifies IKK (inhibitor of κB kinase) as a TFEB modifier, and a combination of phosphorylation assays, mass spectrometry analyses, and site-specific mutagenesis unveils a previously unrecognized TFEB phospho-degron (423SPFPSLS429) as the target of IKK. …

Discerning The Roles Of Novel Glycosyltransferases In The Pathogenic Yeast Cryptococcus Neoformans, Liza Loza

Arts & Sciences Graduate Student Theses and Dissertations

Cryptococcus neoformans (Cn) is an opportunistic fungal pathogen responsible for over 112,000 deaths each year. This yeast is ubiquitous in the environment, where it is particularly associated with soil, trees, and bird excreta. When a susceptible host inhales infectious particles, Cn can proliferate in the lungs before disseminating to the brain to cause an often-fatal meningoencephalitis. Cryptococcosis primarily afflicts those living with uncontrolled HIV/AIDS, accounting for ~15% of AIDS-related mortality. The antifungals available to treat this devastating disease are few in number, toxic to patients, and largely inaccessible in resource-limited settings. The major virulence factor of Cn is its complex …

Trypanophobia: The Scary World Of Tattoos And The Law, Dalton Primeaux

Chicago-Kent Journal of Intellectual Property

No abstract provided.

Enablement For Genus Claims: A Bifurcated Approach, Jie Yang

Chicago-Kent Journal of Intellectual Property

Abstract After two jury trials, two trips to the Federal Circuit, and two petitions to the Supreme Court, the Court this past term decided Amgen Inc. v. Sanofi without much controversy. In a unanimous decision, the Court affirmed the invalidation of Amgen’s functional antibody claims for lack of enablement. As a result, inventors down the road, not just life sciences companies, may find it more difficult to obtain broad patents. Although the Court was clear that Amgen may not “monopolize an entire class of things defined by their function,” the opinion fell short of guiding lower courts on how to …

Comments On Amgen V. Sanofi, Oskar Liivak

Chicago-Kent Journal of Intellectual Property

No abstract provided.

Sceleratin Nitrogen Oxide As Aversive Agent In Conditioning Livestock To Avoid Senecio Latifolius, Leendert D. Snyman

Poisonous Plant Research (PPR)

Sceleratine nitrogen oxide, when administered together with a dichloromethane extract of Senecio latifolius, successfully conditioned cattle and sheep to avoid milled freeze dried S. latifolius mixed with maize meal. This treatment was effectively applied in conditioning steers to refuse eating S. latifolius grown in pots.

The Effect Of Climate Fluctuation On Beekeeping And Honey Production In Babil Governorate, Qusay Fadel Al-Husseini, Hakeem Hassan Abdul Hussein

Uruk Journal of Human Sciences

Climate fluctuations (Climatic is one of the most important issues facing the environment in the province of Babylon, due to the direct impact caused by these fluctuations and oscillations in threatening the diversity of ecosystems and other living organisms, including plants and pollinators, so the current study aims to study the reality of climate oscillation in the province of Babylon, and to identify the extent of its impact on the biodiversity necessary for livelihoods, as the governorate includes a variety of plants and animals. Therefore, climate fluctuation is defined as climatic conditions between years, that is, in the same months …

The Impact Of Climate Changes On The Surface Water Environment In Muthanna Governorate And Its Development Implications, Haider Khairy Ghadia Al-Budairi

Uruk Journal of Human Sciences

The impact of climate change is one of the most important causes of water scarcity and drought that Iraq suffers from in general, especially the central and southern regions, which are the most affected, including Al-Muthanna Governorate. The amounts of precipitation led to a decrease in the discharges of the Euphrates River in the study area from (449) m3/sec in 1978 to (111.2) m3/sec in 2022, noting that the rain contributes to feeding the Iraqi rivers by (42-49%) of the total sources. other nutrition, there is no doubt that this huge decrease in the amount of expenditures affected the various …

Book Review: Military Dogs Of World War Ii, Wylie W. Johnson

Parameters Bookshelf – Online Book Reviews

Author: Susan Bulanda

Reviewed by Reverend Dr. Wylie W. Johnson, chaplain (retired), US Army War College class of 2010

In total war, the nation calls on everyone to direct all resources toward victory—during World War II, that call extended to man’s best friend. Retired military chaplain Dr. Wylie W. Johnson reviews certified animal behavior consultant Susan Bulanda’s Military Dogs of World War II, a photographic history that highlights the value of dogs to the mission of the US military and reminds readers, as Johnson observes, of “the critical contributions made by every level of the force.”

Characterization Of 3d Printed Lattice Structures Used In The Design Of Modified Compression Release Stabilized Transhumeral Prosthetic Sockets, Jade Myers

Theses

Abstract A prosthetic socket is the critical interface between a person and their prosthetic device. Pressure, shear, and friction experienced by the residual limb from wearing a socket can damage soft tissue. While Compression Release Stabilized (CRS) style sockets are beneficial for enhancing prosthesis stability, range of motion, and control, the abrupt differences in compression throughout the socket present risks for tissue damage to the residual limb. A socket design that enables clinicians to control a progressive decrease in firmness in the transition areas between compression and release could mitigate such undesirable effects. Density-graded lattice structures designed and produced with …

Nanoparticles Used In Treatment And Diagnosis Of Leishmaniasis In Iraq: A Review, Harith S. Al-Warid, Layla M. Hasan

Al-Esraa University College Journal for Medical Sciences

The aim of this paper is to identify Nano-particles that have been used in diagnosis and treatment of leishmaniasis in Iraq. All experiments conducted in this field were based on the following nanoparticles: gold nanoparticles, silver nanoparticles, zinc nanoparticles, and sodium chloride nanoparticles. Most of these experiments were reviewed in terms of differences in the concentrations of nanoparticles and the method that was used in the experiments whether it was in vivo or in vitro. These particles used in most experiments succeeded in inhibiting the growth of Leishmania parasites.

Pseudomonas Aeruginosa Epidemiology And Antibiotic Resistance: A Five Years Retrospective Study In Iraq., Huda Ghassan Hameed

Al-Esraa University College Journal for Medical Sciences

One of the leading causes of diseases and deaths across the world are bacterial infections, and the situation is only going to grow worse as antibiotic resistance spreads. Antimicrobial resistance must be closely monitored so as to control the spread of multi-antibiotic-resistant microorganisms. As a result, the goal for the study was to estimate the prevalence of Pseudomonas aeruginosa infection on top of that to look into the antibacterial pattern over the last five years. This retrospective investigation was carried out in various hospitals in Iraq like Central Children's Teaching Hospital for Children, Al Kindi Teaching Hospital, Al-Numan Hospital, Yarmouk …