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2023

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Intelligent Healthcare: Evaluation Potential Implications Of Metaverse In Healthcare Based On Mathematical Decision-Making Framework, Ibrahim Elhenawy, Sara Fawaz Al-Baker, Mona Mohamed Nov 2023

Intelligent Healthcare: Evaluation Potential Implications Of Metaverse In Healthcare Based On Mathematical Decision-Making Framework, Ibrahim Elhenawy, Sara Fawaz Al-Baker, Mona Mohamed

Neutrosophic Systems with Applications

The Metaverse has the ability to restructure and change the manner in which individuals connect with one another as well as the activities that they carry out on a daily basis. One definition of a Metaverse describes it as "a virtual, digital, and three-dimensional universe formed by the integration of various cutting-edge technologies and virtual places." In this piece, we will explore the potential applications of the Metaverse in the medical field. Our conversations on the notion of the Metaverse and the primary technologies that make it possible are both thought-provoking and in-depth. In this article, we study and analyze …

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Natural Protein Intake In Children With Phenylketonuria: Prescription Vs. Actual Intakes, Alex Pinto, Anne Daly, Júlio César Rocha, Catherine Ashmore, Sharon Evans, Fatma Ilgaz, Mary Hickson, Anita Macdonald Nov 2023

Natural Protein Intake In Children With Phenylketonuria: Prescription Vs. Actual Intakes, Alex Pinto, Anne Daly, Júlio César Rocha, Catherine Ashmore, Sharon Evans, Fatma Ilgaz, Mary Hickson, Anita Macdonald

School of Health Professions

In phenylketonuria (PKU), an important component of the UK dietary management system is a 50 mg phenylalanine (Phe)/1 g protein exchange system used to allocate the Phe/natural protein intakes according to individual patient tolerance. Any foods containing protein ≤ 0.5 g/100 g or fruits/vegetables containing Phe ≤ 75 mg/100 g are allowed without measurement or limit. In children with PKU, we aimed to assess the difference between the prescribed natural protein intake and their actual consumed intake, and to calculate the natural protein/Phe intake from foods given without measurement or restriction. Over a 6-month duration, three one-day diet diaries were …

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Staff Perceptions Towards Virtual Reality-Motivated Treadmill Exercise For Care Home Residents: A Qualitative Feedback Study With Key Stakeholders And Follow-Up Interview With Technology Developer, Hannah Louise Bradwell, Leonie Cooper, Katie Jane Edwards, Rory Baxter, Simone A. Tomaz, John Ritchie, Swen Gaudl, Alejandro Veliz-Reyes, Gemma C. Ryde, Tanja Krizaj, Alison Warren, Arunangsu Chatterjee, Katharine Willis, Richard Haynes, Catherine H. Hennessy, Anna C. Whittaker, Sheena Asthana, Ray B. Jones Nov 2023

Staff Perceptions Towards Virtual Reality-Motivated Treadmill Exercise For Care Home Residents: A Qualitative Feedback Study With Key Stakeholders And Follow-Up Interview With Technology Developer, Hannah Louise Bradwell, Leonie Cooper, Katie Jane Edwards, Rory Baxter, Simone A. Tomaz, John Ritchie, Swen Gaudl, Alejandro Veliz-Reyes, Gemma C. Ryde, Tanja Krizaj, Alison Warren, Arunangsu Chatterjee, Katharine Willis, Richard Haynes, Catherine H. Hennessy, Anna C. Whittaker, Sheena Asthana, Ray B. Jones

School of Nursing and Midwifery

Objectives Health and care resources are under increasing pressure, partly due to the ageing population. Physical activity supports healthy ageing, but motivating exercise is challenging. We aimed to explore staff perceptions towards a virtual reality (VR) omnidirectional treadmill (MOTUS), aimed at increasing physical activity for older adult care home residents. Design Interactive workshops and qualitative evaluation. Settings Eight interactive workshops were held at six care homes and two university sites across Cornwall, England, from September to November 2021. Participants Forty-four staff participated, including care home, supported living, clinical care and compliance managers, carers, activity coordinators, occupational therapists and physiotherapists. Interventions …

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Exploring The Effect Of Freight On Tennessee Communities, Mitra Salehi Esfandarani Nov 2023

Exploring The Effect Of Freight On Tennessee Communities, Mitra Salehi Esfandarani

Electronic Theses and Dissertations Archive

This research underscores the critical role of Tennessee's transportation network, particularly its heavy reliance on trucking along rural roads, in facilitating the movement of goods and significantly impacting the state's economy. It emphasizes the need to comprehend the implications of freight transportation on both urban and rural areas, shedding light on the latter's frequent neglect despite substantial impacts. To bridge this disparity, the research focuses on evaluating and mitigating freight-related impacts in suburban and rural communities. The objective is to identify freight movement hotspots, analyze related externalities, and propose mitigation strategies while considering cost-effectiveness and stakeholder welfare. The study highlights …

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Sacred Topographies: The Rhetorical Construction Of Grandfather Mountain As A Sacred Place, Abby Marie Arnold-Patti Nov 2023

Sacred Topographies: The Rhetorical Construction Of Grandfather Mountain As A Sacred Place, Abby Marie Arnold-Patti

Electronic Theses and Dissertations Archive

This study interrogates the ways wilderness spaces become understood as sacred places through rhetoric, using Grandfather Mountain in Western North Carolina as a case study. Using close reading, rhetorical field methods, and social media content analysis, this dissertation examines the rhetorical interpretation, ritualization, contestation, and commodification of wilderness as it comes to be understood and interacted with as sacred. This study offers three significant and interrelated interventions. First, it interrogates how rhetoric works to designate a sacred place. While certain places are understood to be sacred because of their spiritual, historical, or social significance or their natural ecological uniqueness, what …

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Evaluation Of Cyber Insecurities Of The Cyber Physical System Supply Chains Using Α-Discounting Mcdm, Rehab Mohamed, Mahmoud M. Ismail Nov 2023

Evaluation Of Cyber Insecurities Of The Cyber Physical System Supply Chains Using Α-Discounting Mcdm, Rehab Mohamed, Mahmoud M. Ismail

Neutrosophic Systems with Applications

Recently, supply chains (SCs) are applying information technology to enable data sharing among suppliers, instant access to information, and complete tracking of products. With more cybersecurity risks present, such as theft of information, service interruptions, and financial resources risks, the vulnerability of systems is increased. The management of supply chain cybersecurity, which encompasses information systems, software, and infrastructure, is the emphasis of the supply chain's safety measure. There are several serious danger that attack supply chain systems. Most SC Cybersecurity procedures are used to reduce the threats posed by vulnerabilities to those processes. Researchers have mostly concentrated on supply chain-related …

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Development And Application Of Tools And Methods For Behavioral And Neural Recordings In Locusts, Michael R. Traner Nov 2023

Development And Application Of Tools And Methods For Behavioral And Neural Recordings In Locusts, Michael R. Traner

McKelvey School of Engineering Graduate Student Theses & Dissertations

Locusts are a historically important model organism, and have been at the core of many discoveries related to olfaction. In recent years they have become less popular compared to organisms with genetic toolkits such as drosophila, but they have many advantages for studying principles of olfactory chemosensation and related behaviors. In this thesis there are two primary focuses; the development of a surface-bound odorant treadmill (odor-trail treadmill) for studying trail-following behaviors, and the second is the development of tools and procedures to enable simultaneous neural and behavioral recording in locusts. Addressing the first, odor-trail following has been observed in many …

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What Twenty-First-Century Free Speech Law Means For Securities Regulation, Helen Norton Nov 2023

What Twenty-First-Century Free Speech Law Means For Securities Regulation, Helen Norton

Notre Dame Law Review

Securities law has long regulated securities-related speech—and until recently, it did so with little, if any, First Amendment controversy. Yet the antiregulatory turn in the Supreme Court’s twenty-first-century Free Speech Clause doctrine has inspired corporate speakers’ increasingly successful efforts to resist regulation in a variety of settings, settings that now include securities law. This doctrinal turn empowers courts, if they so choose, to dismantle the securities regulation framework in place since the Great Depression. At stake are not only recent governmental proposals to require companies to disclose accurate information about their vulnerabilities to climate change and other emerging risks, but …

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Chronic Disease And The Inflammatory Body Burden: Social And Environmental Factors And Implications For Longevity, Catherine L. Zeman, Junu Shrestha, Raihan Khan, Ashley N. Oginz Wilson, Lisa A. Beltz Nov 2023

Chronic Disease And The Inflammatory Body Burden: Social And Environmental Factors And Implications For Longevity, Catherine L. Zeman, Junu Shrestha, Raihan Khan, Ashley N. Oginz Wilson, Lisa A. Beltz

Department of Health Sciences - Faculty Scholarship

Everyday our body’s immune and detoxification systems are working to protect us from pathogens, cancerous cells, foreign substances, and chemical exposures. Declining trends in per capita longevity in the US suggest that these systems are being stressed beyond their natural resiliency. Several of these trends are discussed in light of funding for preventive vs. illness care. The authors then use a systems and interdisciplinary approach to introduce the immunobiological and biotransformation systems, and the concept of the exposome for those unfamiliar. The science of the immune and detoxification systems is explored considering the idea of chronic low-level inflammation. Additionally, new …

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Disfavoring Statutory Parentheses (Except In Certain Circumstances), Zachary A. Damir Nov 2023

Disfavoring Statutory Parentheses (Except In Certain Circumstances), Zachary A. Damir

Notre Dame Law Review

Parentheses in statutes have been at issue in an increasing number of court cases, even at the Supreme Court. Parentheses have a slightly different story from other punctuation marks and they have been used consistently throughout legal history. The Federal Constitution, early statutes, and a large part of our modern state and federal law separate words from their sentences using parentheses. But if a parenthetical conflicts with the material outside of the parentheses, it is the current practice to discard the interior text as surplus-age, even though the legislature may have had a reason to include that text in a …

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Jackfish (Caranx Lugubris) Neurocranium, Lauren Groves, David Kerstetter Nov 2023

Jackfish (Caranx Lugubris) Neurocranium, Lauren Groves, David Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

Neurocranium from 9 cm total length (TL) Jackfish, Caranx lugubris, collected from Ideal Market on September 18th, by Lauren Groves

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Brha, Kevin Rafferty, Briana K. Zaffiro, David W. Kerstetter Nov 2023

Brha, Kevin Rafferty, Briana K. Zaffiro, David W. Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

Skull from Broad-winged Hawk (Buteo platypterus).

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N6-Methyladenosine-Mediated Overexpression Of Long Noncoding Rna Adamts9-As2 Triggers Neuroblastoma Differentiation Via Regulating Lin28b/Let-7/Mycn Signaling, Yun Liu, Jun Zhang, Fang Cao, Xiaobao Dong, Jie Li, Yanna Cao, Zhanglin Li, Yan Guo, Jie Yan, Yuanyuan Liu, Qiang Zhao Nov 2023

N6-Methyladenosine-Mediated Overexpression Of Long Noncoding Rna Adamts9-As2 Triggers Neuroblastoma Differentiation Via Regulating Lin28b/Let-7/Mycn Signaling, Yun Liu, Jun Zhang, Fang Cao, Xiaobao Dong, Jie Li, Yanna Cao, Zhanglin Li, Yan Guo, Jie Yan, Yuanyuan Liu, Qiang Zhao

Faculty, Staff and Student Publications

Neuroblastomas have shed light on the differentiation disorder that is associated with spontaneous regression or differentiation in the same tumor at the same time. Long noncoding RNAs (lncRNAs) actively participate in a broad spectrum of biological processes. However, the detailed molecular mechanisms underlying lncRNA regulation of differentiation in neuroblastomas remain largely unknown. Here, we sequenced clinical samples of ganglioneuroma, ganglioneuroblastoma, and neuroblastoma. We compared transcription profiles of neuroblastoma cells, ganglion cells, and intermediate state cells; verified the profiles in a retinoic acid-induced cell differentiation model and clinical samples; and screened out the lncRNA ADAMTS9 antisense RNA 2 (ADAMTS9-AS2), which contributed …

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The Impact Of Environmental Factors And Management On The Fitness Of Carlina Acaulis Subsp. Caulescens (Lam.) Schübl. Et G. Martens In Mountain Mesic Meadows, Daniel Pruchniewicz, Ȃngela Lomba, Ludwik Żołnierz, Agnieszka Dradrach, João Pradinho Honrado Nov 2023

The Impact Of Environmental Factors And Management On The Fitness Of Carlina Acaulis Subsp. Caulescens (Lam.) Schübl. Et G. Martens In Mountain Mesic Meadows, Daniel Pruchniewicz, Ȃngela Lomba, Ludwik Żołnierz, Agnieszka Dradrach, João Pradinho Honrado

Turkish Journal of Botany

The stemless carline thistle (Carlina acaulis subsp. caulescens) is a plant species commonly found at lower altitudes in the Central European mountains. Although it is still relatively frequent in the area, there has been a decrease in its numbers in the last decades. This research aims to determine the impact of the management of mountain mesic meadows and habitat factors on the morphometric variability of C. acaulis and species composition patterns of accompanying vegetation. The study was carried out in the central part of the Sudetes Mountains (SW Poland) on a network of 42 plots randomly established within mesic grasslands. …

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Ethnobotany Of Medicinal Plants Used In Dermatology In Türkiye: A Review, Serpi̇l Demi̇rci̇ Kayiran, Meryem Parlak, Di̇dem Yilmaz Oral Nov 2023

Ethnobotany Of Medicinal Plants Used In Dermatology In Türkiye: A Review, Serpi̇l Demi̇rci̇ Kayiran, Meryem Parlak, Di̇dem Yilmaz Oral

Turkish Journal of Botany

Medicinal plants are increasingly used to treat skin diseases and as cosmetics. Türkiye has a rich diversity of medicinal flora, and patients have a choice of ethnomedicines to manage various dermatology problems. This comprehensive review aims to summarize the primary information available on the dermatological properties of medicinal plants in Türkiye and provide a baseline for the detection of new plant species having efficacy against skin conditions. In this review, clinical and experimental data were researched using relevant search terms in scientific literature databases like PubMed, Web of Science, Google Scholar, ScienceDirect, Scopus, EBSCO, ProQuest, Cochrane Library, and HighWire Press. …

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A Comprehensive Ethnobotanical Survey Of Medicinal Plants For 80 Villages In Trabzon (Türkiye), Sila Ozlem Sener, Kami̇l Çoşkunçelebi̇, Sali̇h Terzi̇oğlu, Aleyna Nalçaoğlu, Tuğçe Peli̇n Gençkaya, Ufuk Özgen, Merve Yüzbaşioğlu Baran Nov 2023

A Comprehensive Ethnobotanical Survey Of Medicinal Plants For 80 Villages In Trabzon (Türkiye), Sila Ozlem Sener, Kami̇l Çoşkunçelebi̇, Sali̇h Terzi̇oğlu, Aleyna Nalçaoğlu, Tuğçe Peli̇n Gençkaya, Ufuk Özgen, Merve Yüzbaşioğlu Baran

Turkish Journal of Botany

The current study targeted to perform qualitative and quantitative analysis of medicinal plant taxa used in folk medicine in Trabzon. Due to its historical significance, diversity of plant species, and hosting a wide range of cultures, the Turkish city of Trabzon has significant ethnobotanical potential. Ethnobotanical data including family name, scientific name, local name, used parts, therapeutic uses, preparation methods, administration routes, and cited locations were gathered by face-to-face interviews with 645 participants mostly over 50 years old. The quantitative analyses were executed by the determination of frequency values of citation (FC), use value (UV), fidelity level (FL), and informant …

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Biochar Influences On Phytochemical Composition And Expression Genes Of Curly Kale At Different Treatment Times, Joyce Dedei Anteh, Esraa Almugrabi, Antonina Mostyakova, Olga Timofeeva Nov 2023

Biochar Influences On Phytochemical Composition And Expression Genes Of Curly Kale At Different Treatment Times, Joyce Dedei Anteh, Esraa Almugrabi, Antonina Mostyakova, Olga Timofeeva

Turkish Journal of Botany

his study examined the effect of biochar application to the soil at different times on the phytochemical composition (phenolic compounds, carotenoids, vitamin C, sugars, proteins, MDA, and antioxidant activity) and expression of HCT, F3’H and CHS genes (which are involved in the accumulation of phenolic compounds) in cabbage kale (Brassica oleracea L. var. acephala). Biochar was prepared from chicken manure, using the method of rapid pyrolysis at a temperature of 400 °C. The retention time at the maximum temperature was 4 h, and the heating rate was 10 °C min–1. The biochar fertilizer was applied to 5–7 day-old kale seedlings …

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Influence Of Rootstock Age And Gibberellin On The Survival Rate Of Clove (Syzygium Aromaticum L. Merr. & Perr.) Grafting, Ireng Darwati, Rudi Suryadi, Nurliani Bermawie, Octivia Trisilawati, Devi Rusmin, Sri Wahyuni, Siswanto Siswanto, R Vitri Garvita Nov 2023

Influence Of Rootstock Age And Gibberellin On The Survival Rate Of Clove (Syzygium Aromaticum L. Merr. & Perr.) Grafting, Ireng Darwati, Rudi Suryadi, Nurliani Bermawie, Octivia Trisilawati, Devi Rusmin, Sri Wahyuni, Siswanto Siswanto, R Vitri Garvita

Turkish Journal of Botany

Clove (Syzygium aromaticum) is a cross-pollinated crop with significant genetic variation in planting materials derived from seeds. Vegetative propagation through grafting is a valuable strategy to achieve genetically identical characteristics in progeny. This study investigates the influence of rootstock age and hormone (gibberellin) treatments on the grafting union and survival rate of top clove grafting under greenhouse conditions. The experiments followed a randomized block design with three replications, each containing 10 samples, and involving two factors: rootstock age (4, 6, and 8 weeks old) and gibberellin (GA3 ) concentrations (0 and 1 mg L–1). The variables observed include success percentage, …

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Northern Red Snapper (Lutjanus Campechnus) Neurocranium, Ajani K. Saldana, David Kerstetter Nov 2023

Northern Red Snapper (Lutjanus Campechnus) Neurocranium, Ajani K. Saldana, David Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

Neurocranium from 7.5 cm total length (TL) 37 cm Lutjanus campechanus (Northern Red Snapper), collected from Mango Tree Supermarket in September 2023 by Ajani Saldana

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Blsk 3d Scan, Kevin Rafferty, Briana K. Zaffiro, David Kerstetter Nov 2023

Blsk 3d Scan, Kevin Rafferty, Briana K. Zaffiro, David Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

Skull from Black Skimmer (Rhnchops niger)

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Beta-Carbonic Anhydrase Gene Expression Levels Change Depending On The Drought Severity In Both The Leaves And Roots Of Arabidopsis Thaliana, Sertan Çevi̇k, Oğuzhan Kurt, Ayşi̇n Güzel Değer, Ferit Kocaçinar, Rıza Bi̇nzet Nov 2023

Beta-Carbonic Anhydrase Gene Expression Levels Change Depending On The Drought Severity In Both The Leaves And Roots Of Arabidopsis Thaliana, Sertan Çevi̇k, Oğuzhan Kurt, Ayşi̇n Güzel Değer, Ferit Kocaçinar, Rıza Bi̇nzet

Turkish Journal of Botany

In this study, it was aimed to determine the relationship between β carbonic anhydrase (βCA) gene expression levels and drought stress severity. For this purpose, the expression levels of six βCA genes in the roots and leaves of Arabidopsis thaliana were investigated under mild, moderate, and severe drought conditions. In addition, changes in the biomass, leaf water content, photosynthetic efficiency, CA enzyme activity, free proline content, and lipid peroxidation were also determined. The results showed that all of the β CA gene expression levels and CA enzyme activity increased in the leaf under mild drought conditions; however, the expression levels …

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Glial Cell Adhesion Molecule (Glialcam) Determines Proliferative Versus Invasive Cell States In Glioblastoma, Arpan De, John M Lattier, John E Morales, Jack R Kelly, Xiaofeng Zheng, Zhihua Chen, Sumod Sebastian, Zahra Nassiri Toosi, Jason T Huse, Frederick F Lang, Joseph H Mccarty Nov 2023

Glial Cell Adhesion Molecule (Glialcam) Determines Proliferative Versus Invasive Cell States In Glioblastoma, Arpan De, John M Lattier, John E Morales, Jack R Kelly, Xiaofeng Zheng, Zhihua Chen, Sumod Sebastian, Zahra Nassiri Toosi, Jason T Huse, Frederick F Lang, Joseph H Mccarty

Faculty, Staff and Student Publications

The malignant brain cancer glioblastoma (GBM) contains groups of highly invasive cells that drive tumor progression as well as recurrence after surgery and chemotherapy. The molecular mechanisms that enable these GBM cells to exit the primary mass and disperse throughout the brain remain largely unknown. Here we report using human tumor specimens and primary spheroids from male and female patients that glial cell adhesion molecule (GlialCAM), which has normal roles in brain astrocytes and is mutated in the developmental brain disorder megalencephalic leukoencephalopathy with subcortical cysts (MLC), is differentially expressed in subpopulations of GBM cells. High levels of GlialCAM promote …

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The Implications Of Ferroptosis In Antibiotic Resistance, Marysol Hohl Nov 2023

The Implications Of Ferroptosis In Antibiotic Resistance, Marysol Hohl

Senior Honors Theses

Bacterial infections in the United States are becoming increasingly resistant to existing antibiotic treatments. Due to projected increases in resistance and the recent decrease in novel antibacterials, experts have determined that the United States is in the “post-antibiotic era.” The scientific community has failed to resolve resistance despite the continual discovery of new antibiotic compounds. In the past decade, a novel form of cell death called ferroptosis has been implicated in antibiotic treatment by employing the use of nanotechnology. This literature review will describe the problem of bacterial resistance and demonstrate how current research is pioneering a new age of …

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Dopamine, Norepinephrine And Serotonin Participate Differently In Methylphenidate Action In Concomitant Behavioral And Ventral Tegmental Area, Locus Coeruleus And Dorsal Raphe Neuronal Study In Young Rats, Cruz Reyes-Vasquez, Zachary Jones, Bin Tang, Nachum Dafny Nov 2023

Dopamine, Norepinephrine And Serotonin Participate Differently In Methylphenidate Action In Concomitant Behavioral And Ventral Tegmental Area, Locus Coeruleus And Dorsal Raphe Neuronal Study In Young Rats, Cruz Reyes-Vasquez, Zachary Jones, Bin Tang, Nachum Dafny

Faculty, Staff and Student Publications

Methylphenidate (MPD), known as Ritalin, is a psychostimulant used to treat children, adults, and the elderly. MPD exerts its effects through increasing concentrations of dopamine (DA), norepinephrine (NE), and serotonin (5-HT) in the synaptic cleft. Concomitant behavioral and neuronal recording from the ventral tegmental area (VTA), locus coeruleus (LC), and from the dorsal raphe (DR) nucleus, which are the sources of DA, NE, and 5-HT to the mesocorticolimbic circuit, were investigated following acute and repetitive (chronic) saline, 0.6, 2.5, or 10.0 mg/kg MPD. Animals received daily saline or MPD administration on experimental days 1 to 6 (ED1–6), followed by a …

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2023-11-22 Can We Trust Our Politicians Anymore?, Naja Johnson Nov 2023

2023-11-22 Can We Trust Our Politicians Anymore?, Naja Johnson

The Spectator Online

No abstract provided.

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Clinical, Genetic And Structural Delineation Of Rpl13-Related Spondyloepimetaphyseal Dysplasia Suggest Extra-Ribosomal Functions Of El1, Prince Jacob, Hillevi Lindelöf, Cecilie F Rustad, Vernon Reid Sutton, Shahida Moosa, Prajna Udupa, Anna Hammarsjö, Gandham Srilakshmi Bhavani, Dominyka Batkovskyte, Kristian Tveten, Ashwin Dalal, Eva Horemuzova, Ann Nordgren, Emma Tham, Hitesh Shah, Else Merckoll, Laura Orellana, Gen Nishimura, Katta M Girisha, Giedre Grigelioniene Nov 2023

Clinical, Genetic And Structural Delineation Of Rpl13-Related Spondyloepimetaphyseal Dysplasia Suggest Extra-Ribosomal Functions Of El1, Prince Jacob, Hillevi Lindelöf, Cecilie F Rustad, Vernon Reid Sutton, Shahida Moosa, Prajna Udupa, Anna Hammarsjö, Gandham Srilakshmi Bhavani, Dominyka Batkovskyte, Kristian Tveten, Ashwin Dalal, Eva Horemuzova, Ann Nordgren, Emma Tham, Hitesh Shah, Else Merckoll, Laura Orellana, Gen Nishimura, Katta M Girisha, Giedre Grigelioniene

Faculty, Staff and Students Publications

Spondyloepimetaphyseal dysplasia with severe short stature, RPL13-related (SEMD-RPL13), MIM#618728), is a rare autosomal dominant disorder characterized by short stature and skeletal changes such as mild spondylar and epimetaphyseal dysplasia affecting primarily the lower limbs. The genetic cause was first reported in 2019 by Le Caignec et al., and six disease-causing variants in the gene coding for a ribosomal protein, RPL13 (NM_000977.3) have been identified to date. This study presents clinical and radiographic data from 12 affected individuals aged 2-64 years from seven unrelated families, showing highly variable manifestations. The affected individuals showed a range from mild to severe short stature, …

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Coregnet: Unraveling Gene Co-Regulation Networks From Public Rna-Seq Repositories Using A Beta-Binomial Statistical Model, Jiasheng Wang, Ying-Wooi Wan, Rami Al-Ouran, Meichen Huang, Zhandong Liu Nov 2023

Coregnet: Unraveling Gene Co-Regulation Networks From Public Rna-Seq Repositories Using A Beta-Binomial Statistical Model, Jiasheng Wang, Ying-Wooi Wan, Rami Al-Ouran, Meichen Huang, Zhandong Liu

Faculty, Staff and Students Publications

Millions of RNA sequencing samples have been deposited into public databases, providing a rich resource for biological research. These datasets encompass tens of thousands of experiments and offer comprehensive insights into human cellular regulation. However, a major challenge is how to integrate these experiments that acquired at different conditions. We propose a new statistical tool based on beta-binomial distributions that can construct robust gene co-regulation network (CoRegNet) across tens of thousands of experiments. Our analysis of over 12 000 experiments involving human tissues and cells shows that CoRegNet significantly outperforms existing gene co-expression-based methods. Although the majority of the genes …

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Clinical, Genetic And Structural Delineation Of Rpl13-Related Spondyloepimetaphyseal Dysplasia Suggest Extra-Ribosomal Functions Of El13, Prince Jacob, Hillevi Lindelöf, Cecilie F Rustad, Vernon Reid Sutton, Shahida Moosa, Prajna Udupa, Anna Hammarsjö, Gandham Srilakshmi Bhavani, Dominyka Batkovskyte, Kristian Tveten, Ashwin Dalal, Eva Horemuzova, Ann Nordgren, Emma Tham, Hitesh Shah, Else Merckoll, Laura Orellana, Gen Nishimura, Katta M Girisha, Giedre Grigelioniene Nov 2023

Clinical, Genetic And Structural Delineation Of Rpl13-Related Spondyloepimetaphyseal Dysplasia Suggest Extra-Ribosomal Functions Of El13, Prince Jacob, Hillevi Lindelöf, Cecilie F Rustad, Vernon Reid Sutton, Shahida Moosa, Prajna Udupa, Anna Hammarsjö, Gandham Srilakshmi Bhavani, Dominyka Batkovskyte, Kristian Tveten, Ashwin Dalal, Eva Horemuzova, Ann Nordgren, Emma Tham, Hitesh Shah, Else Merckoll, Laura Orellana, Gen Nishimura, Katta M Girisha, Giedre Grigelioniene

Faculty, Staff and Students Publications

Spondyloepimetaphyseal dysplasia with severe short stature, RPL13-related (SEMD-RPL13), MIM#618728), is a rare autosomal dominant disorder characterized by short stature and skeletal changes such as mild spondylar and epimetaphyseal dysplasia affecting primarily the lower limbs. The genetic cause was first reported in 2019 by Le Caignec et al., and six disease-causing variants in the gene coding for a ribosomal protein, RPL13 (NM_000977.3) have been identified to date. This study presents clinical and radiographic data from 12 affected individuals aged 2-64 years from seven unrelated families, showing highly variable manifestations. The affected individuals showed a range from mild to severe short stature, …

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Hyperleptinemia Contributes To Antipsychotic Drug-Associated Obesity And Metabolic Disorders, Shangang Zhao, Qian Lin, Wei Xiong, Li Li, Leon Straub, Dinghong Zhang, Rizaldy Zapata, Qingzhang Zhu, Xue-Nan Sun, Zhuzhen Zhang, Jan-Bernd Funcke, Chao Li, Shiuhwei Chen, Yi Zhu, Nisi Jiang, Guannan Li, Ziying Xu, Steven C Wyler, May-Yun Wang, Juli Bai, Xianlin Han, Christine M Kusminski, Ningyan Zhang, Zhiqiang An, Joel K Elmquist, Olivia Osborn, Chen Liu, Philipp E Scherer Nov 2023

Hyperleptinemia Contributes To Antipsychotic Drug-Associated Obesity And Metabolic Disorders, Shangang Zhao, Qian Lin, Wei Xiong, Li Li, Leon Straub, Dinghong Zhang, Rizaldy Zapata, Qingzhang Zhu, Xue-Nan Sun, Zhuzhen Zhang, Jan-Bernd Funcke, Chao Li, Shiuhwei Chen, Yi Zhu, Nisi Jiang, Guannan Li, Ziying Xu, Steven C Wyler, May-Yun Wang, Juli Bai, Xianlin Han, Christine M Kusminski, Ningyan Zhang, Zhiqiang An, Joel K Elmquist, Olivia Osborn, Chen Liu, Philipp E Scherer

Faculty, Staff and Students Publications

Despite their high degree of effectiveness in the management of psychiatric conditions, exposure to antipsychotic drugs, including olanzapine and risperidone, is frequently associated with substantial weight gain and the development of diabetes. Even before weight gain, a rapid rise in circulating leptin concentrations can be observed in most patients taking antipsychotic drugs. To date, the contribution of this hyperleptinemia to weight gain and metabolic deterioration has not been defined. Here, with an established mouse model that recapitulates antipsychotic drug-induced obesity and insulin resistance, we not only confirm that hyperleptinemia occurs before weight gain but also demonstrate that hyperleptinemia contributes directly …

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Heterogeneous Cardiac Sympathetic Innervation Gradients Promote Arrhythmogenesis In Murine Dilated Cardiomyopathy, Al-Hassan J Dajani, Carla Valenzuela-Ripoll, Ali Javaheri, Et Al. Nov 2023

Heterogeneous Cardiac Sympathetic Innervation Gradients Promote Arrhythmogenesis In Murine Dilated Cardiomyopathy, Al-Hassan J Dajani, Carla Valenzuela-Ripoll, Ali Javaheri, Et Al.

2020-Current year OA Pubs

Ventricular arrhythmias (VAs) in heart failure are enhanced by sympathoexcitation. However, radiotracer studies of catecholamine uptake in failing human hearts demonstrate a proclivity for VAs in patients with reduced cardiac sympathetic innervation. We hypothesized that this counterintuitive finding is explained by heterogeneous loss of sympathetic nerves in the failing heart. In a murine model of dilated cardiomyopathy (DCM), delayed PET imaging of sympathetic nerve density using the catecholamine analog [11C]meta-Hydroxyephedrine demonstrated global hypoinnervation in ventricular myocardium. Although reduced, sympathetic innervation in 2 distinct DCM models invariably exhibited transmural (epicardial to endocardial) gradients, with the endocardium being devoid of sympathetic nerve …

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