Digital Commons Network^™

Host Immunity Associated With Spontaneous Suppression Of Viremia In Therapy-Naïve Young Rhesus Macaques Following Neonatal Shiv Infection., Tyler D. Evangelous, Madison Berry, Sravani Venkatayogi, Cas Lemaster, Eric S. Geanes, Nicole De Naeyer, Todd Demarco, Xiaoying Shen, Hui Li, Bhavna Hora, Nicholas Solomonis, Johnathan Misamore, Mark G. Lewis, Thomas N. Denny, David Montefiori, George M. Shaw, Kevin Wiehe, Todd Bradley, Wilton B. Williams

Manuscripts, Articles, Book Chapters and Other Papers

Despite the advent of highly active anti-retroviral therapy, people are still dying from HIV-related causes, many of whom are children, and a protective vaccine or cure is needed to end the HIV pandemic. Understanding the nature and activation states of immune cell subsets during infection will provide insights into the immunologic milieu associated with viremia suppression that can be harnessed via therapeutic strategies to achieve a functional cure, but these are understudied in pediatric subjects. We evaluated humoral and adaptive host immunity associated with suppression of viremia in rhesus macaques infected soon after birth with a pathogenic SHIV. The results …

Evaluation Of Solid Medical Waste Management In Bogor Regional Public Hospitals, Silvia Khansa, Agustin Kusumayati, Dewi Susanna, Uli Tiarma Sinaga

Kesmas

Healthcare facilities generate medical waste. If not properly managed, medical waste may damage the environment and spread diseases. Many hospitals in Indonesia do not adhere to medical waste management regulations. This study aimed to evaluate the management of solid medical waste at four public hospitals in Bogor District, Indonesia. A case study design was used to obtain a comprehensive description of the solid medical waste management activities inthe hospitals. Data were collected through direct observations, interviews, and document reviews. This study revealed that the medical waste generated in allhospitals was infectious, pathological, pharmaceutical, chemical, and cytotoxic, totaling approximately 4,000-12,000 kg. …

Two Multilingual Regions In Southwestern Amazonia, Hein Van Der Voort

Tipití: Journal of the Society for the Anthropology of Lowland South America

Southwestern Amazonia is one of the most linguistically diverse regions of the Americas. It is possible that traditional Indigenous small-scale multilingualism used to exist in two neighboring regions in what is now Rondônia, on the Brazilian side of the Guaporé River. Permanent contact with representatives of Western society from the beginning of the twentieth century onwards led to great demographic, social, cultural, and economic upheaval among the Indigenous societies in the Rio Branco-Colorado and the Apediá-Corumbiara river basins. Early ethnographic reports suggest that these societies were characterized by traditional small-scale multilingualism. In this article, I summarize the evidence for this …

The Nyadran Dam Bagong Tradition As A Reflection Of Local Culture In Strengthening Multicultural Education And Human Rights Awareness, Indah Yunitasari, Rina Mariyana, Fitrotul Mukaromah

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

This study examines multicultural values in the Nyadran Dam Bagong tradition, its relevance to human rights awareness, and strategies for integrating these values into multicultural education in primary schools through a local-content approach. The findings show values of tolerance, cooperation, cultural identity, gender equality, and freedom of belief.

Defragging Feminist Cyberlaw, Amanda Levendowski

Georgetown Law Faculty Publications and Other Works

In 1996, Judge Frank Easterbrook famously observed that any effort to create a field called cyberlaw would be “doomed to be shallow and miss unifying principles.” He was wrong, but not for the reason other scholars have stated. Feminism is a unifying principle of cyberlaw, which alternately amplifies and abridges the feminist values of consent, safety, and accessibility. Cyberlaw simply hasn’t been understood that way—until now.

In computer science, “defragging” means bringing together disparate pieces of data so they are easier to access. Inspired by that process, this Article offers a new approach to cyberlaw that illustrates how feminist values …

Big Screen Heroes With Paper Voices: A Superhero Adaptation Research Essay, Zachary Green

Master of Arts in Professional Writing Capstones

Superheroes may have taken over your phone, tablet, and television screens through the endless adaptations that pelt us from upon high mouse-shaped ears, but their rich history goes back much further than that; they have gripped the public imagination since their creation in comic strips published in newspapers almost one-hundred years ago. But, why exactly has their effect on popular culture, and their subsequent adaptations in various forms of media been so pervasive in the last twenty-five years? What makes these stories and comic book characters, and particularly Marvel comic book characters, so interesting to modern audiences? This essay demonstrates …

Device Closure Of Superior Sinus Venosus Atrial Septal Defects: A Single Centre Experience, Salim N. Al Maskari, Madan M. Maddali, Khalid Al Alawi, Sowmiya Raju, Abdulla Al-Farqani

Sultan Qaboos University Medical Journal

Sinus venosus atrial septal defects present a wide variety of anatomical features and are frequently associated with partial anomalous pulmonary venous drainage of one or more right pulmonary veins. Surgical correction used to be the standard treatment. In recent times, transcatheter correction of superior sinus venosus atrial septal defects has come into vogue. The transcatheter closure of these defects with covered stents at a tertiary care centre in Oman between 2018 and 2023 is reported.

Is Forced Coughing Effective In Reducing Pain During Cervical Biopsy?: A Systematic Review And Meta-Analysis, Yassamine Ouerdane, Aya Abd Elmegeed, Mohammed Tarek, Imane Bakhtaoui, Ahmed K. Awad, Nihal Al Riyami, Ahmed Saad

Sultan Qaboos University Medical Journal

This review aimed to compare the potential analgesic effect of forced coughing (FC) with that of local anaesthetics (LA) or placebo during cervical biopsy. A total of 5 electronic databases—Scopus, PubMed, Web of Science, Cochrane Library and Google Scholar—were systematically searched from inception till March 2021. Data were extracted from 6 randomised controlled trials and analysed. During cervical biopsy, the overall effect favoured LA over FC (mean difference [MD] = 1.06, 95% confidence interval [CI]: 0.58 to 1.54; P <0.0001). Compared to no pain management, pooled data were comparable between the two groups (MD = −1.2, 95% CI: −3.35 to 0.94; P = 0.27). Procedure duration was significantly longer in the LA group than in the FC group (MD = −1.94, 95% CI: −2.47 to −1.41; P <0.00001). FC and LA are both useful pain-lowering modalities during cervical biopsy, depending on the setting and their availability.

Intraoperative And Postoperative Outcomes Of Modified Bidirectional Intra-Umbilical Incision Versus Infra-Umbilical Incision For Direct Trocar Insertion In Gynaecological Laparoscopy: A Randomised Controlled Trial, Atef Darwish, Mohammad Tawfik, Amal Gaflan, Dina Darwish

Sultan Qaboos University Medical Journal

Objectives: This study aimed to describe a modified, curved, deep, bidirectional, intra-umbilical, vertical incision for primary trocar insertion and prospectively compare its intraoperative and postoperative outcomes with an infra-umbilical incision in gynaecologic laparoscopy. Methods: Between August 2019 and March 2021, 110 patients subjected to the direct trocar insertion technique for laparoscopic intervention were classified into two groups. Group A comprised 55 cases of infra-umbilical incision, whereas group B comprised 55 cases of a modified, curved, longitudinal, deep, bidirectional, intra-umbilical incision. Afterwards, intraoperative and postoperative assessments were performed. Results: The increase in the numbers of parity, gravidity and previous caesarean sections …

Fuzzycsampling: A Hybrid Fuzzy C-Means Clustering Sampling Strategy For Imbalanced Datasets, Abdullah Maraş, Çi̇ğdem Erol

Turkish Journal of Electrical Engineering and Computer Sciences

Classification model with imbalanced datasets is recently one of the most researched areas in machine learning applications since they induce to the emergence of low-performing machine learning models. The imbalanced datasets occur if target variables have an uneven number of examples in a dataset. The most prevalent solutions to imbalanced datasets can be categorized as data preprocessing, ensemble techniques, and cost-sensitive learning. In this article, we propose a new hybrid approach for binary classification, named FuzzyCSampling, which aims to increase model performance by ensembling fuzzy c-means clustering and data sampling solutions. This article compares the proposed approaches' results not only …

Vaupés Multilingualism And The Substance Of Language, Stephen Hugh-Jones

Tipití: Journal of the Society for the Anthropology of Lowland South America

By focusing on ordinary conversational language, relying on a notion of “group” derived from unilineal descent theory, and neglecting mythology and ritual, studies of Vaupés Tukanoan multilingualism have inadvertently tended to reproduce a Western ideology of language as marking national identity and concerned with conveying meaning. This paper suggests that attention to musical, ritual, and shamanic contexts reveals multilingualism in a different light, with ritual speech acts as constitutive of social groups, names as vehicles of reproduction, and breath as a substance-like bodily element and source of vitality. The more esoteric, rhetorical, musical, or visual ornamentation is given to breath, …

Clever Animals: Naturalcultural Interactions In Karitiana Hunting Practices (Rondônia, Brazil), Felipe Vander Velden

Tipití: Journal of the Society for the Anthropology of Lowland South America

This article addresses hunting practices and human-animal relations among the Karitiana, a Tupi-Arikém-speaking indigenous people in the southwestern Brazilian Amazon, asserting that if humans can learn from animals in long-lasting hunting experiences in the forest, animals can also learn how to deal with their human predators as well as their knowledge and techniques. Furthermore, animals must be understood here as species and individuals. This is an almost natural conclusion drawn from Amazonian ethnography, which suggests that distinctions between humans and the nonhumans that we call animals are not classified according to a categorization in which human beings have resourcefulness and …

Delineating The Interplay Between Oncogenic Pathways And Immunity In Anaplastic Wilms Tumors, Xiaoping Su, Xiaofan Lu, Sehrish Khan Bazai, Linda Dainese, Arnauld Verschuur, Benoit Dumont, Roger Mouawad, Li Xu, Wenxuan Cheng, Fangrong Yan, Sabine Irtan, Véronique Lindner, Catherine Paillard, Yves Le Bouc, Aurore Coulomb, Gabriel G Malouf

Faculty, Staff and Student Publications

Wilms tumors are highly curable in up to 90% of cases with a combination of surgery and radio-chemotherapy, but treatment-resistant types such as diffuse anaplastic Wilms tumors pose significant therapeutic challenges. Our multi-omics profiling unveils a distinct desert-like diffuse anaplastic Wilms tumor subtype marked by immune/stromal cell depletion, TP53 alterations, and cGAS-STING pathway downregulation, accounting for one-third of all diffuse anaplastic cases. This subtype, also characterized by reduced CD8 and CD3 infiltration and active oncogenic pathways involving histone deacetylase and DNA repair, correlates with poor clinical outcomes. These oncogenic pathways are found to be conserved in anaplastic Wilms tumor cell …

Attempts To Understand Oral Mucositis In Head And Neck Cancer Patients Through Omics Studies: A Narrative Review, Erin Marie D San Valentin, Kim-Anh Do, Sai-Ching J Yeung, Cielito C Reyes-Gibby

Faculty, Staff and Student Publications

Oral mucositis (OM) is a common and clinically impactful side effect of cytotoxic cancer treatment, particularly in patients with head and neck squamous cell carcinoma (HNSCC) who undergo radiotherapy with or without concomitant chemotherapy. The etiology and pathogenic mechanisms of OM are complex, multifaceted and elicit both direct and indirect damage to the mucosa. In this narrative review, we describe studies that use various omics methodologies (genomics, transcriptomics, microbiomics and metabolomics) in attempts to elucidate the biological pathways associated with the development or severity of OM. Integrating different omics into multi-omics approaches carries the potential to discover links among host …

What Matters To You? Engaging With Children In The James Lind Alliance Children’S Cancer Priority Setting Partnership, Susie Aldiss, Penelope Hart-Spencer, Loveday Langton, Sonia Malik, Keeley Mcevoy, Jessica E Morgan, Rosa Reed-Berendt, Rachel Hollis, Bob Phillips, Faith Gibson, James Lind Alliance Children’S Cancer Priority Setting Partnership Steering Group

Faculty, Staff and Student Publications

BACKGROUND: Previous priority setting exercises have sought to involve children, but in the final reporting, it is evident that few children had been engaged through the process. A primary aim in the Children's Cancer Priority Setting Partnership was to find out from children what they want research to focus on. We report on our experience to inform methods of engagement with children in future James Lind Alliance Priority Setting Partnerships and similar exercises.

METHODS: We followed the James Lind Alliance process, collecting and shortlisting questions via online surveys with adult survivors of childhood cancer, carers, and professionals, and holding a …

Quaker Campus, November 30, 2023 (Vol. 22, Issue 7), Whittier College

Quaker Campus

No abstract provided.

Association Between E-Cigarette Use And Myocardial Infarction: A Systematic Review And Meta-Analysis, Muhammad Talal Ashraf, Asim Shaikh, Muhammad Shakeel Khuzzaim Khan, Naseer Uddin, Muhammad Arham Bin Kashif, Syed Hassan Ahmed Rizvi, Hammad Khalid, Stafford Jude Sam, Affan Sohail

Department of Medicine

Background: The popularity of e-cigarettes has risen dramatically over the last few years, particularly among the younger population. Although the use of combustible cigarettes has established evidence to be associated with the development of several adverse cardiopulmonary diseases, the investigations regarding the prospective long-term effects of e-cigarette use on the cardiovascular system have just begun. We set to investigate if there is an association between the history of MI and e-cigarette use among smokers and non-smokers?
Methods: The current review aims to assess the association of myocardial infarction with e-cigarette consumption. PubMed, Google Scholar, and Cochrane Central Register of Controlled …

How Are We Supposed To Respond To This?: Me Too As A Social Transformation Movement, Julia Dolfo De Castro

Social Transformations Journal of the Global South

This paper attempts to demonstrate how the Me Too movement is crucial in social transformation precisely because it demands a rethinking of current normativities, such as those surrounding gender and sexual norms, power relations, and culture. Through Nikolas Kompridis’s “reflective disclosure,” this paper argues that the Me Too movement as a critique employs a stance of receptivity to reinvigorate its critical perspectives and fuel its political commitments to freedom and transformation. This paper aims to accomplish two things: (1) to tackle the “burden” of hearers/listeners of “me too” to respond; (2) to introduce the possibilities of receptivity in social transformation …

Dada Docot, Stephen Acabado, And Clement Camposano, Eds. Plural Entanglements: Philippine Studies. Quezon City: Ateneo De Manila University Press, 2023. 451 Pp., Perseville Umali Mendoza Phd

Social Transformations Journal of the Global South

Excerpt: The book presents an attempt to revisit and recontextualize approaches to contemporary Philippine Studies. It seeks to locate the field of study locally and globally, noting that there are different ways of interrogating and therefore, extending the discussions to cover the Philippines’s place in the global community. There is a growing global scholarship on Philippine Studies, making it possible to have a continuity of discussion from the past that is not limited to an essentialist approach but one that is cognizant of the plurality entailed by the global nature of contemporary discourse. Caroline Hau writes in the foreword that …

Cannabinoids In Periodontology: Where Are We Now?, Yésica Carmona Rendón, Hernán Santiago Garzón, Bruno Bueno-Silva, Roger M Arce, Lina Janeth Suárez

Faculty, Staff and Student Publications

Introduction: Cannabinoids are a well-documented treatment modality for various immune and inflammatory diseases, including asthma, chronic obstructive pulmonary disease, Crohn's disease, arthritis, multiple sclerosis, and a range of neurodegenerative conditions. However, limited information is available regarding the therapeutic potential of cannabinoids in treating periodontal disease.

Objective: The objective of this study is to analyze the current evidence on the antibacterial and immunomodulatory effects of cannabis and its role in the healing and regeneration processes within periodontal tissues.

Results: This review discusses the potential role of cannabinoids in restoring periodontal tissue homeostasis.

Conclusions: The examination of the endocannabinoid system and the …

Learning With Treescapes In Environmentally Endangered Times

Occasional Paper Series

No abstract provided.

Arboreal Methodologies: Getting Lost To Explore The Potential Of The Non-Innocence Of Nature, Jayne Osgood, Suzanne Axelsson, Tamsin Cavaliero, Máire Hanniffy, Susan Mcdonnell

Occasional Paper Series

This paper recounts a workshop that took place in a polytunnel in a forest school in Sligo, North-West Ireland on a cold day in early-December. The event sought to materialize ‘arboreal methodologies’ (Osgood, 2019; Osgood & Odegard, 2022; Osgood & Axelsson, 2023) which are characterized by the enactment of feminist new materialist praxis to engage in world-making practices (Haraway, 2008) intended to unsettle recognizable tropes of biophilia that have come to frame both child and nature in narrow ways. The arboreal methodologies that participants were invited to mobilise were situated, material, affective, and involved metaphorical and material practices of ‘getting …

Trees In Our City How A Tree And A Small Patch Of Dirt Inspired A Classroom, Zuleika Hines

Occasional Paper Series

As a new Director in a new school, I knew that I wanted the children to have a curiosity for nature. But to lead the children to a place of discovery, they would need the opportunity to observe, play, and engage in elements of nature that would support hands-on activities both in the classroom and outside. When the opportunity came for me to build my own early childhood program, I knew that I had a unique opportunity to incorporate elements of nature in the design of the classroom. But I wanted nature to be local and the trees of our …

The Refugee Trees: Treescapes As Intercultural Bridges, Kostas Magos, Irida Tsevreni

Occasional Paper Series

Forests, groves, parks as well as any area with fewer or more trees can be a suitable field for students' environmental awareness. Even a single tree as a subject of thoughtful observation can give children opportunities for discussion around many issues such as those of environmental protection, endangered species, human's relationship with nature and many more. Ιn addition to environmental awareness, trees can also contribute to the intercultural awareness of students. In all cultures without exception, trees and plants have a particularly important place and there are many myths, stories and traditions associated with them. Also, the great variety of …

Singing In Dark Times: Improvisational Singing With Children Amidst Ecological Crisis, Stephanie Schuurman-Olson

Occasional Paper Series

Through this research-creation project -- which is represented by a process-driven ten-minute video -- the author asks what ways of knowing emerge when children and adults, more-than-human, and inhuman engage in improvised singing together in an urban park? This project recognizes our current "dark times" within ecological collapse and operates from a space that hopes to build relationality with sonic ecologies through listening-and-singing experiences, while centering the voices of children and other singers within the ecologies we sing in-and-with.

Painting Our Treescapes: A Visual, Gretel Olson, Ingrid Olson, Stephanie Schuurman-Olson

Occasional Paper Series

Two children (ages 6 and 9) represent an afternoon spent in their urban, wintery treescape through visual art, photo documentation, and written narrative. The first piece, "My Imaginary Forest", considers the seasons, animals, and issues of artistic representation of nature. The second piece describes the relationship between a favourite tree and a child, and considers others -- both present and future -- who also occupy "Our Knotty Tree". All of the words, visual art, and photo selection are those of the children.

Connecting Children And Young People With Trees, Gill Forrester, Jo Maker, Will Price, Hollie Davison, Heather Gilbert

Occasional Paper Series

Engaging children and young people with the natural world has never been more important. The benefits of outdoor learning span from increased nature connection to improved self-esteem and physical wellbeing. But with so many potential risks and barriers, how can we help practitioners feel confident and capable in an outdoor setting and therefore improve access to green space for children and young people? The education team at the National Forest Company set out to tackle this challenge. The National Forest was established in the early 1990s in a post-industrial area of the English Midlands. It covers 200 square miles and …

Making Kin With Trees: Three Educators And Children Entangled With Treescapes, Stephanie Jones, Lindsey Lush, Sarah Whitaker

Occasional Paper Series

In this article, three educators from one small U.S. city draw on Donna Haraway’s feminist, posthumanist idea of making kin to explore their personal relations with trees and their work as educators to support children’s entanglements with trees. Working in three very different contexts with children: a working-class neighborhood, a public school kindergarten, and a forest kindergarten, the three authors illuminate the “magical” emergences of making kin with trees that fundamentally shifts what becomes possible to do and be. Their writing contributes to the fields of critical childhood geographies, feminist posthumanist pedagogies in early childhood education, and writing in affect …

Trees And Us: Learning About/From Trees And Treescapes From Primary School Children In The United Kingdom, Samyia Ambreen, Khawla Badwan, Kate Pahl

Occasional Paper Series

In recent years, there is a growing interest for attending to children’s voice in environmental research. The theoretical developments in knowledge about children view them as social agents who can make sense of their own experiences in relation to the environment surrounded them. In this report, we add reflections from an ongoing project “voices of the future” which aims to reimagine future of treescapes in the UK. Using examples from two primary schools in the northwest of England, we discuss children’s knowledge about trees and how children talk about their lived experiences with trees. Centring on our field work experiences, …

Traces Of Worms, Zoey Ashcroft

Occasional Paper Series

The setting was a day spent planting trees outside the school grounds. As Zoey and her classmates planted the trees, they also recorded the activity in their notebooks. The children noticed the worms that were wriggling in the ground. Zoey recorded an activity in which leaves and then worms were lifted from the earth, and the worms then explored the page where they were put. Afterward, the worms were lifted off the page and put back on the ground. The traces of the worms were left on the page. We were left with traces of worms.