Digital Commons Network^™

Organ Aging Signatures In The Plasma Proteome Track Health And Disease, Hamilton Se-Hwee Oh, Yun Ju Sung, Lihua Wang, Jigyasha Timsina, Dan Western, Menghan Liu, Pat Kohlfeld, John Budde, Carlos Cruchaga, Et Al.

2020-Current year OA Pubs

Animal studies show aging varies between individuals as well as between organs within an individual

Conserved And Divergent Gene Regulatory Programs Of The Mammalian Neocortex, Nathan R Zemke, Daofeng Li, Xiaoyu Zhuo, Vincent Xu, Ting Wang, Et Al.

2020-Current year OA Pubs

Divergence of cis-regulatory elements drives species-specific traits

Recombinant Human Perlecan Dv And Its Lg3 Subdomain Are Neuroprotective And Acutely Functionally Restorative In Severe Experimental Ischemic Stroke, Ifechukwude Joachim Biose, Ibolya Rutkai, Bryan Clossen, Gary Gage, Kenneth Schechtman, H Davis Adkisson 4th, Gregory J Bix

2020-Current year OA Pubs

Despite recent therapeutic advancements, ischemic stroke remains a major cause of death and disability. It has been previously demonstrated that  ~ 85-kDa recombinant human perlecan domain V (rhPDV) binds to upregulated integrin receptors (α2β1 and α5β1) associated with neuroprotective and functional improvements in various animal models of acute ischemic stroke. Recombinant human perlecan laminin-like globular domain 3 (rhPDV

Idasanutlin And Navitoclax Induce Synergistic Apoptotic Cell Death In T-Cell Acute Lymphoblastic Leukemia, Kimberly B Johansson, Megan S Zimmerman, Iryna V Dmytrenko, Feng Gao, Daniel C Link

2020-Current year OA Pubs

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy in which activating mutations in the Notch pathway are thought to contribute to transformation, in part, by activating c-Myc. Increased c-Myc expression induces oncogenic stress that can trigger apoptosis through the MDM2-p53 tumor suppressor pathway. Since the great majority of T-ALL cases carry inactivating mutations upstream in this pathway but maintain wildtype MDM2 and TP53, we hypothesized that T-ALL would be selectively sensitive to MDM2 inhibition. Treatment with idasanutlin, an MDM2 inhibitor, induced only modest apoptosis in T-ALL cells but upregulated the pro-apoptotic BH3 domain genes BAX and BBC3, prompting …

An "Off-The-Shelf" Cd2 Universal Car-T Therapy For T-Cell Malignancies, Jingyu Xiang, Jessica M Devenport, Alun J Carter, Karl W Staser, Miriam Y Kim, Julie O' Neal, Julie K Ritchey, Michael P Rettig, Feng Gao, Garrett Rettig, Rolf Turk, Byung Ha Lee, Matthew L Cooper, John F Dipersio

2020-Current year OA Pubs

T-cell malignancies are associated with frequent relapse and high morbidity, which is partly due to the lack of effective or targeted treatment options. To broaden the use of CAR-T cells in pan T-cell malignancies, we developed an allogeneic "universal" CD2-targeting CAR-T cell (UCART2), in which the CD2 antigen is deleted to prevent fratricide, and the T-cell receptor is removed to prevent GvHD. UCART2 demonstrated efficacy against T-ALL and CTCL and prolonged the survival of tumor-engrafted NSG mice in vivo. To evaluate the impact of CD2 on CAR-T function, we generated CD19 CAR-T cells (UCART19) with or without CD2 deletion, single-cell …

Single-Cell Analysis Of Chromatin Accessibility In The Adult Mouse Brain, Songpeng Zu, Yang Eric Li, Et Al.

2020-Current year OA Pubs

Recent advances in single-cell technologies have led to the discovery of thousands of brain cell types; however, our understanding of the gene regulatory programs in these cell types is far from complete

Trpv4 Differentially Controls Inflammatory Cytokine Networks During Static And Dynamic Compression Of The Intervertebral Disc, Garrett W D Easson, Alireza Savadipour, Christian Gonzalez, Farshid Guilak, Simon Y Tang

2020-Current year OA Pubs

BACKGROUND: The ion channel transient receptor potential vanilloid 4 (TRPV4) critically transduces mechanical forces in the IVD, and its inhibition can prevent IVD degeneration due to static overloading. However, it remains unknown whether different modes of loading signals through TRPV4 to regulate the expression of inflammatory cytokines. We hypothesized that TRPV4 signaling is essential during static and dynamic loading to mediate homeostasis and mechanotransduction.

METHODS: Mouse functional spine units were isolated and either cyclically compressed for 5 days (1 Hz, 1 h, 10% strain) or statically compressed (24 h, 0.2 MPa). Conditioned media were monitored at 6 h, 24 h, …

Increasing Energetic Demands On Photoreceptors In Diabetes Corrects Retinal Lipid Dysmetabolism And Reduces Subsequent Microvascular Damage, Sheng Zhang, Xiaochao Wei, Megan Bowers, Sebastian Jessberger, Marcin Golczak, Clay F Semenkovich, Rithwick Rajagopal

2020-Current year OA Pubs

Mechanisms responsible for the pathogenesis of diabetic retinal disease remain incompletely understood, but they likely involve multiple cellular targets, including photoreceptors. Evidence suggests that dysregulated de novo lipogenesis in photoreceptors is a critical early target of diabetes. Following on this observation, the present study aimed to determine whether two interventions shown to improve diabetic retinopathy in mice-pharmacologic visual cycle inhibition and prolonged dark adaptation-reduce photoreceptor anabolic lipid metabolism. Elevated retinal lipid biosynthetic signaling was observed in two mouse models of diabetes, with both models showing reduced retinal AMP-activated kinase (AMPK) signaling, elevated acetyl CoA carboxylase (ACC) signaling, and increased activity …

Gc-448 Project Title: Discover, Learn, And Protect: A Mobile App For Informal Stem Learning About Local Biodiversity And Environmental Issues., Elvin Mccray, David Y. Appah, Adedunmola Banu, Binh Tran, Zenya Tucker

C-Day Computing Showcase

Our team assignment for this project was to create a mobile application that offers informal STEM learning about local biodiversity and environmental issues. Dr. Ying Xie, Professor in the College of Computing and Software Engineering (CCSE) is the owner of this project, who also laid out required features and provided necessary information, guidance, and advice for the project development. The core function of this application is to empower users to explore, identify and gain insights into the plant and animal species native to their region. Leveraging the capabilities of their smartphone’s camera, users can effortlessly scan, record, or locate local …

Uc-523: It 4983 Server Hardening, Manuel Chico, Gilbert Vuong, Harrison Jones, George Barber

C-Day Computing Showcase

The team was assigned the responsibility of securing a web server. This business website is hosted on a technology stack comprising Apache, MariaDB, Red Hat Linux, and PHP. Our initial task involves conducting a comprehensive assessment of the provided network to identify vulnerabilities and assess potential risks. Subsequently, we will develop a robust security policy plan in alignment with the standards set forth by the National Institute of Standards and Technology (NIST) and industry best practices. Once the plan was approved, our group will proceed to implement the recommended changes to fortify the network, ensuring it complies with industry best …

Uc-413 I Spy... Water Safety, Caden M. Robertson, Danny Winters, Denice Jaquez, Tahj Brown, Maksims D. L'Hernault

C-Day Computing Showcase

I Spy Water Safety is a game that teaches people about the importance of water safety around a lake. Our goal is to teach people proper water safety etiquette and lower the amount of water-related incidents.

Uc-508 Memories: Echoes Of Resilience, Ethan J Hester, Joshua Tyler Padgett, Katelyn R Freeman, Sarah Crosby, Keith W Rhymer

C-Day Computing Showcase

Memories: Echoes of Resilience is a first-person narrative experience that takes players through different experiences of a boy with autism. The game aims to show how everyday interactions can be different to someone with autism. Experiences such as making friends in school, being in overstimulating environments, or managing adult life are experiences we want to simulate for the player. The player will be able to interact with the world around them but will also have to be aware of how their environment impacts them, so they don’t become overstimulated.

Moral Exemplars Of Note - Horst-Klaus Hofmann, Sam And Pearl Oliner

Moral Exemplars Study

Moral Exemplars of Note - Horst-Klaus Hofmann, Sam and Pearl Oliner

Lung Dosimetry Model Of Inhaled 222rn For Workers At Selected Building Material Factories In Erbil City, Iraq, Sardar Qader Othman, Ali Hassan Ahmed, Sarbaz Ibrahim Mohammed

Polytechnic Journal

Radon gas can cause lung harm, leading to extensive research on the biological effects of radon exposure in human lungs under various environmental conditions. The study estimates radon progeny doses for workers in Erbil city's building materials industries, focusing on alpha particle energy deposition, particle clearance, and lung deposition. Using a home condition of 1 Bq.m-3, radon progeny particle-absorbed doses in the trachea, bronchi, bronchioles, alveolar-interstitial sections, and lungs were determined in the first scenario. The 1 Bq.m-3 is replaced with the radon level for each factory to prepare its atmosphere in the second scenario. For the first scenario, the …

The Chanticleer, 2023-11-30, Coastal Carolina University

The Chanticleer Student Newspaper

The editorially independent student produced weekly newspaper of Coastal Carolina University.

Issue 432: November 30-December 14, 2023, The Local Voice

The Local Voice

No abstract provided.

The Black Garden, Madalene Klocke

Theses

“The Black Garden” is a novel-length fantasy fiction work. It follows the narrative of Ryan, an 18-year-old girl, who has great expectations for what her first year at university will hold. Her entire world view is tilted when she attends a party with her new roommate, Blair, and wakes up in an unfamiliar place. Ryan must fight to keep her sanity as she is thrust into the world of faeries, witches, and far worse creatures than she could have ever imagined: including her parents.

Trehalose Enhances Mitochondria Deficits In Human Npc1 Mutant Fibroblasts But Disrupts Mouse Purkinje Cell Dendritic Growth Ex Vivo., Collin M Macleod, Fawad A K Yousufzai, Liam T Spencer, Sarah Kim, Lucianne A Rivera-Rosario, Zerian D Barrera, Lindsay Walsh, Claude Krummenacher, Benjamin Carone, Ileana Soto

College of Science & Mathematics Departmental Research

Lysosomes play important roles in catabolism, nutrient sensing, metabolic signaling, and homeostasis. NPC1 deficiency disrupts lysosomal function by inducing cholesterol accumulation that leads to early neurodegeneration in Niemann-Pick type C (NPC) disease. Mitochondria pathology and deficits in NPC1 deficient cells are associated with impaired lysosomal proteolysis and metabolic signaling. It is thought that activation of the transcription factor TFEB, an inducer of lysosome biogenesis, restores lysosomal-autophagy activity in lysosomal storage disorders. Here, we investigated the effect of trehalose, a TFEB activator, in the mitochondria pathology of NPC1 mutant fibroblasts in vitro and in mouse developmental Purkinje cells ex vivo. We …

Curriculum Subcommittee Agenda December 7, 2023, Utah State University

Educational Policies Committee

• Program Proposals
• Semester Course Approval Reviews
• Other Business
• Adjourn

Give Back To The Community This Season With Uab, Shannon Thomason

Browse All News

No abstract provided.

Of Fluffy Robes And Prose, Erma Bombeck Writers' Workshop

Erma Bombeck Writers' Workshop Blog

By day, Kara Kinney Cartwright is a legal editor from North Potomac, Maryland, but her superpower is "trying to save the world with punchy humor about unwritten social rules and expectations."

Florida Stone Crab (Menippe Mercenaria), Ariel R. Velligan Ms., Amy Hirons Dr

Hirons Field Techniques

Florida Stone Crab (Menippe mercenaria) with a total width of 9.5 cm and carapace width of 5.1 cm from Dr. Hirons lab collection.

Lionfish (Pterois Volitans) Neurocranium, Kate Heffner, Hosanna Gattle, David Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

Neurocranium from 30 cm total length (TL) Lionfish (Pterois volitans), collected from Second Reef on 15/10/2023 by Kate Heffner.

Relationships Among Development, Growth, Body Size, Reproduction, Aging, And Longevity - Trade-Offs And Pace-Of-Life., Rong Yuan, Erin Hascup, Kevin Hascup, Andrzej Bartke

Articles

Relationships of growth, metabolism, reproduction, and body size to the biological process of aging and longevity have been studied for decades and various unifying "theories of aging" have been proposed to account for the observed associations. In general, fast development, early sexual maturation leading to early reproductive effort, as well as production of many offspring, have been linked to shorter lifespans. The relationship of adult body size to longevity includes a remarkable contrast between the positive correlation in comparisons between different species and the negative correlation seen in comparisons of individuals within the same species. We now propose that longevity …

Machine Learning Based Bioinformatics Analysis Of Intron Usage Alterations And Metabolic Regulation In Adipose Browning, Hamza Umut Karakurt, Pinar Pi̇r

Turkish Journal of Electrical Engineering and Computer Sciences

Adipose tissue is the major energy depot of the body and is considered an endocrine organ. Adipose tissue involves many different cell types, first and foremost, the adipocytes. White adipose cells that store fat and brown adipocytes that take part in lipid oxidation and heat generation are the most common cell types in adipose tissue. Even though brown adipocytes which have a high number of mitochondria and high fat-burning capacity are rare in adults, they are abundant in newborns and rodents. White adipocytes can gain a temporal brown-like character with a process called browning, which can be induced with cold …

Modulation Of Zebrafish (Danio Rerio) Intestinal Mucosal Barrier Function Fed Different Postbiotics And A Probiotic From Lactobacilli, Mark Rawling, Marion Schiavone, Amélie Mugnier, Eric Leclercq, Daniel Merrifield, Andrew Foey, Emmanuelle Apper

School of Biological and Marine Sciences

It is generally accepted that microbes play a critical role in maintaining gut barrier function, making them ideal to target in order to mitigate the effects of intestinal diseases such as inflammatory bowel disease with specialist supplementations such as probiotic or postbiotic preparations. In this study, specific strains of Lactobacillus helvictus both live and inactivated and Lactobacillus plantarum inactivated were fed to zebrafish at an inclusion level of 6 × 106 cells/g in order to assess the effects on gut barrier function and protection. Taken together, our results indicate that dietary administration of pro- or postbiotics strengthens the gut barrier …

Assessment Of Ethanol And Nicotine Interactions Using A Reinforcer Demand Modeling With Grouped And Individual Levels Of Analyses In A Long-Access Self-Administration Model Using Male Rats, Christopher L. Robison, Nicole Cova, Victoria Madore, Tyler Allen, Scott T. Barrett, Sergios Charntikov

Department of Psychology: Faculty Publications

Previous reports have indicated the reciprocal effects of nicotine and ethanol on their rewarding and reinforcing properties, but studies using methodological approaches resembling substance use in vulnerable populations are lacking. In our study, rats first self-administered ethanol, and their sensitivity to ethanol’s reinforcing effects was assessed using a reinforcer demand modeling approach. Subsequently, rats were equipped with intravenous catheters to self-administer nicotine, and their sensitivity to nicotine’s reinforcing effects was evaluated using the same approach. In the final phase, rats were allowed to self-administer ethanol and nicotine concurrently, investigating the influence of one substance on the rate of responding for …

The Age Of The Onanya - Regarding The Spread Of Ayahuasca Use Throughout The Ucayali Basin, Carlos Suárez-Álvarez

Tipití: Journal of the Society for the Anthropology of Lowland South America

The spread of ayahuasca shamanism throughout the Upper Amazon has become a matter of debate among scholars since, in 1994, anthropologist Peter Gow formulated the controversial suggestion that it could be a recent phenomenon in the Ucayali basin, usually considered the stronghold of a millenary tradition. Following Gow, Brabec de Mori argued that the Shipibo-Conibo people, a paradigmatic example of the antique practice of ayahuasca shamanism, adopted both the brew and the associated shamanic practices in a “relatively recent” past. Gow and Brabec pointed at the Maynas missions as the origin of this shamanic complex, and the mestizo and Cocama …

Yellowtail Snapper Ocyurus Chrysurus, Kevin Rafferty, Manuel Ploner, David W. Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

YELLOWTAIL SNAPPER OCYURUS CHRYSURUS 7.5CM Total length

Development And Validation Of Molnupiravir Assessment In Bulk Powder And Pharmaceutical Formulation By The Rp-Hplc-Uv Method, Ekram Hany Mohamed, A. H. Abdel Aziz, Noha M. El Zahar,, Nour El-Din A. Abdel-Sattar, Safwat A. Mahmoud,, Mohamed S. Attia,

Pharmacy

An accurate, sensitive and selective RP-HPLC-UV method has been established for the estimation of Molnupiravir (MOL) in pure bulk powder and pharmaceutical formulation. Separation was achieved on an Inertsil C18 column (150.0 mm × 4.6 mm, 5.0 μm), using a mobile phase of 20 mM phosphate buffer pH 2.5 : acetonitrile (80 : 20, v/v%) in isocratic mode with a flow rate of 1.0 mL min−1. The λmax of MOL prepared in the chosen diluent (ethanol : water in equal proportions) was found to be 230.0 nm. The constructed calibration curve was found to be linear in the concentration range …