Digital Commons Network^™

Forecasting Traffic Speed During Daytime From Google Street View Images Using Deep Learning, Junfeng Jiao, Huihai Wang

Research Collection College of Integrative Studies

Traffic forecasting plays an important role in urban planning. Deep learning methods outperform traditional traffic flow forecasting models because of their ability to capture spatiotemporal characteristics of traffic conditions. However, these methods require high-quality historical traffic data, which can be both difficult to acquire and non-comprehensive, making it hard to predict traffic flows at the city scale. To resolve this problem, we implemented a deep learning method, SceneGCN, to forecast traffic speed at the city scale. The model involves two steps: firstly, scene features are extracted from Google Street View (GSV) images for each road segment using pretrained Resnet18 models. …

Social Media Impacts On Arkansas Consumer Perceptions Of Gmos, Elizabeth R. Berner

Graduate Theses and Dissertations

This study builds upon previous consumer perceptions of GMOs studies. A need existed to determine what, if any, effects social media messages about GMOs had on consumer perceptions in Arkansas. The study utilized a qualitative approach with three focus groups. Data were analyzed using descriptive code. Participants were found to have a general understanding of GMOs, though discussion about what a GMO product was took an uncertain tone. Most participants did not consider GMOs as a factor when purchasing products. Rather participants considered characteristics such as price, quality, and convenience. Participants did not believe the infographics had changed their opinions …

Competencies Texas A&M Agrilife Extension Agents Need To Manage Conflict In Master Gardener Programs, Jayla Brook Fry

Electronic Theses and Dissertations

Texas A&M AgriLife Extension agents manage volunteer programs with vast efforts in public education. Volunteer programs such as the Texas Master Gardener program are significant to the public because they provide a service by educating people in horticulture and related topics. Extension agents oversee volunteer programs such as the Master Gardener program. The Texas Master Gardener program is comprised of more than 9,000 volunteers who give over 500,000 hours of service to their communities. When there are misaligned goals or personality conflicts, it may impact the program’s mission and educational efforts. Extension agents must manage those situations to retain the …

Project: Mhealth Applications For Educating Community Nurses, Nkemdilim Stacy Egbo

Electronic Theses and Dissertations

Hypertension is a chronic health condition linked to high morbidity and mortality rates in America and around the world. Hypertension care in developing and underdeveloped countries requires quick intervention. The proliferation of smart technologies and mobile health applications offer some leverage for the alternative management of hypertension, but evidence related to effectiveness in Nigeria are limited. The purpose of the study was to assess the impact of m-Health apps on hypertension self-management through nurses’ education in Southern region of Nigeria, as well as their self-confidence or efficacy using the Hypertension Evaluation of Lifestyle Management assessment. A quasi-experimental pretest-posttest design was …

Evaluation Of Cardiovascular Risk Compliance For Primary Prevention: A Quality Improvement Project, Rachelle S. Campbell

Electronic Theses and Dissertations

The American College of Cardiology and American Heart Association clinical practice guidelines recommend a cardiovascular risk assessment every 4–6 years in ages 40–75 to prevent cardiovascular disease. This DNP project aimed to improve awareness, compliance with cardiac risk assessments, and stratification of high and low-risk patients. This quality improvement project utilized the Johns Hopkins nursing evidence-based model to create the inquiry question and foundational plan for implementing the clinical practice guideline, calculating the cardiac risk score, and creating a clinical workflow process. A retrospective chart audit was guided by the Plan-Do-Study-Act (PDSA) method to collect pre- and postintervention data on …

Developing Recommendations For Broad Mite, Polyphagotarsonemus Latus Banks, In Blackberry, Rubus Subgenus Rubus, Jared Bradley Linn

Graduate Theses and Dissertations

Broad mite, (Polyphagotarsonemus latus Banks) (Acari: Tarsonemidae), is an economically important pest of blackberry production across the world. Since it was first reported on primocane-fruiting blackberries in 2010, little work has gone into developing IPM tools and understanding impact on floricane-fruiting cultivars. The objective of this thesis was to evaluate the effect of broad mite feeding on floricane-fruiting cultivars of blackberry, develop an efficient and accurate field scouting strategy, and investigate the impact of cultivar and trellising technique on the development of broad mite populations. Experiments consisted of evaluating floricane fruiting cultivars by quantifying broad mite populations and cataloging their …

Assessment Of Needs And Priorities For Precision Agriculture And Soil Testing In Arkansas, Solomon Frimpong

Graduate Theses and Dissertations

Optimum crop production is needed to meet the growing population's food, water, fiber, and energy needs. However, agricultural productivity is hampered by many destabilizing factors such as pest management challenges, declining water quantity, and climate change which threaten long-term food security. Maximizing productivity will require optimizing resources through Precision Agriculture (PA) by supplying inputs based on crop needs. Precision Agriculture offers tools that can be used to optimize crop management practices globally. However, stakeholders’ perceptions and the lack of data-driven site-specific recommendations limit stakeholders’ ability to fully harness the potential benefits of PA. Identification of stakeholder needs and approaches to …

Characterization Of Human Fibroblast Growth Factor 2 Variant To Determine Effects On Structure, Stability, And Cell Proliferation, Ryan Layes

Graduate Theses and Dissertations

Fibroblast growth factors (FGFs) are a family of cell signaling proteins conserved across multiple species. Each individual FGF elicits different cellular functions including, but not limited to, proliferation, migration, differentiation, angiogenesis, and wound healing. One of the most studied members, fibroblast growth factor 2 (FGF2), has demonstrated substantial wound healing capacity in a wide range of tissues including skeletal, muscular, neural, respiratory, epithelial, and cardiovascular. This ability makes FGF2 a potential therapeutic for a wide range of conditions and injuries. However, due to a short half-life at room temperature, therapeutic use of FGF2 is limited. It has been demonstrated that …

Exosomal Tar Dna Binding Protein 43 Profile In Canine Model Of Amyotrophic Lateral Sclerosis: A Preliminary Study In Developing Vlood-Based Biomarker For Neurodegenerative Diseases, Penelope Pfeiffer, Joan R. Coates, Yajaira M. Esqueda, Andrew Kennedy, Kyleigh Getchell, Myra Mclenon, Edina Kosa, Abdulbaki Agbas

Faculty and Staff Publications

Objective: Blood-based biomarkers provide a crucial information in the progress of neurodegenerative diseases with a minimally invasive sampling method. Validated blood-based biomarker application in people with amyotrophic lateral sclerosis would derive numerous benefits. Canine degenerative myelopathy is a naturally occurring animal disease model to study the biology of human amyotrophic lateral sclerosis. Serum derived exosomes are potential carriers for cell-specific cargoes making them ideal venue to study biomarkers for a variety of diseases and biological processes. This study assessed the exosomal proteins that may be assigned as surrogate biomarker that may reflect biochemical changes in the central nervous system.

Methods: …

How Is The Christian Virtue Of Detachment Epistemically Transformative?, Simon C. Summers

Electronic Theses and Dissertations

This thesis aims to understand how the Christian virtue of detachment, understood as the proper ordering of one’s desires toward God, contributes to epistemic transformation. In order to achieve this result, I rely on the work of the Trappist monk, Thomas Merton, beginning by mapping out his conception of detachment and demonstrating how it helps one to overcome competing desires and find their true self. Following this, I offer an account of the type of epistemic transformation required to access some theistic knowledge in order to connect Merton’s views on the topic with those of modern-day philosophers and show the …

2023 December, Morehead State University. Office Of Communications & Marketing.

Morehead State Press Release Archive, 1961 to the Present

Press releases for December of 2023.

Effect Of Plant Genotype On Plant-Microbe Interactions And Multi-Generation Ecosystem Selection Of Microbial Communities Associated With Plant Biomass In Arabidopsis Thaliana, Nachiket Shankar

Graduate Doctoral Dissertations

The microbiome's role in shaping host phenotypes is a critical area of investigation, with implications for ecology, evolution, and host health. Dynamic plant-microbe interactions are influenced by factors like soil type, environment, and genotype. Understanding their impact on microbial communities is key for tailored plant benefits. An artificial ecosystem selection experiment was done for eight generations with Arabidopsis thaliana Ler and Cvi. This revealed distinct microbial communities shaped by genotypes and biomass treatments. Initially, environment dominated, but over time, genotype and biomass gained influence, explaining ~40% of the variation. Moreover, genotype-specific rhizobacterial associations were observed, enhancing understanding of community dynamics …

A New Method To Evaluate Pressure Distribution Using A 3d-Printed C2-C3 Cervical Spine Model With An Embedded Sensor Array, Frank Vrionis

All Publications

Cervical degenerative disc diseases such as myelopathy and radiculopathy often require conventional treatments like artificial cervical disc replacement or anterior cervical discectomy and fusion (ACDF). When designing a medical device, like the stand-alone cage, there are many design inputs to consider. However, the precise biomechanics of the force between the vertebrae and implanted devices under certain conditions require further investigation. In this study, a new method was developed to evaluate the pressure between the vertebrae and implanted devices by embedding a sensor array into a 3D-printed C2-C3 cervical spine. The 3D-printed cervical spine model was subjected to a range of …

C³: Code Clone-Based Identification Of Duplicated Components, Yanming Yang, Ying Zou, Xing Hu, David Lo, Chao Ni, John C. Grundy, Xin: Xia

Research Collection School Of Computing and Information Systems

Reinventing the wheel is a detrimental programming practice in software development that frequently results in the introduction of duplicated components. This practice not only leads to increased maintenance and labor costs but also poses a higher risk of propagating bugs throughout the system. Despite numerous issues introduced by duplicated components in software, the identification of component-level clones remains a significant challenge that existing studies struggle to effectively tackle. Specifically, existing methods face two primary limitations that are challenging to overcome: 1) Measuring the similarity between different components presents a challenge due to the significant size differences among them; 2) Identifying …

The Relationship Between Balance Confidence And Center Of Pressure In Lower-Limb Prosthesis Users, Gary Guerra, John Smith, Eun-Jung Yoon

All Faculty Scholarship (Archived)

Background: Agreement between the activities-specific balance confidence scale (ABC) and center of pressure (CoP) in prosthesis users is still very much unknown. The purpose of this study was to investigate the agreement between ABC and CoP in lower-limb prosthesis users. Methods: Twenty-one individuals with lower-limb prostheses were recruited. Participants were provided with the ABC scale and performed static balance tasks during eyes opened (EO) and eyes closed (EC) conditions whilst standing on a force platform. Pearson product moment coefficients between CoP displacements and ABC scores were performed. Participants were also stratified by those who had better (≥80 on ABC scale) …

Tumor Treating Fields: Narrative Review Of A Promising Treatment Modality For Cancer, Tugce Kutuk, Alonso La Rosa De Los Rios, Rupesh Kotecha, Minesh Mehta, Michael Chuong

All Publications

Background and objective: Tumor treating fields (TTFields) therapy have emerged as a potentially effective treatment for various malignancies by delivering low-intensity, intermediate-frequency electrical fields that disrupt many processes inside cells, resulting in the interruption of cell division in cancer cells. Additionally, TTFields therapy has been found to be synergistic with existing therapeutic approaches. In this review, we provide an introduction and background to the primary mechanisms of TTFields and discuss the emerging preclinical and clinical outcomes of this novel cancer treatment technology.

Methods: We performed a literature search on PubMed, ClinicalTrials.Gov, and Google Scholar using the terms 'TTFields' and 'cancer'. …

When Is It Fair To Break Promises? Illuminating Promissory Estoppel's Inequity Requirement, Marcus Moore

All Faculty Publications

Promissory estoppel is an important adjunct to contract law, allowing non-contractual promises to be legally binding under prescribed conditions. These conditions include reliance by the promisee, as the doctrine serves to protect reasonable reliance induced by certain types of promises. Typically, the conditions also include a requirement that it would be inequitable for the promisor to go back on the promise. This inequity requirement reflects the nature of promissory estoppel as a creature of the law of equity. Beyond this, however, considerable uncertainty surrounds the inequity element. For example, there are diverging views as to whether it embodies a distinct …

A Tale Of Two Calcium Disorders: Hypercalcemia In Pregnancy, Marc Stezzi Do, Clarissa Hayes Do, Merissa Misiura Md, Emily C. Skutnik Do, Gretchen A. Perilli Md, Sharmila C. Koshy Md

Department of Medicine

No abstract provided.

Radiation-Induced Innate Neutrophil Response In Tumor Is Mediated By The Cxcls/Cxcr2 Axis, Faya Zhang, Oscar Mulvaney, Erica Salcedo, Subrata Manna, James Z Zhu, Tao Wang, Chul Ahn, Laurentiu M Pop, Raquibul Hannan

Faculty, Staff and Student Publications

The early events that lead to the inflammatory and immune-modulatory effects of radiation therapy (RT) in the tumor microenvironment (TME) after its DNA damage response activating the innate DNA-sensing pathways are largely unknown. Neutrophilic infiltration into the TME in response to RT is an early innate inflammatory response that occurs within 24-48 h. Using two different syngeneic murine tumor models (RM-9 and MC-38), we demonstrated that CXCR2 blockade significantly reduced RT-induced neutrophilic infiltration. CXCR2 blockade showed the same effects on RT-induced tumor inhibition and host survival as direct neutrophil depletion. Neutrophils highly and preferentially expressed CXCR2 compared to other immune …

Multi-Ancestry Study Of The Genetics Of Problematic Alcohol Use In Over 1 Million Individuals, Hang Zhou, Emma C Johnson, Pamela A F Madden, Andrew C Heath, Arpana Agrawal, Et Al.

2020-Current year OA Pubs

Problematic alcohol use (PAU), a trait that combines alcohol use disorder and alcohol-related problems assessed with a questionnaire, is a leading cause of death and morbidity worldwide. Here we conducted a large cross-ancestry meta-analysis of PAU in 1,079,947 individuals (European, N = 903,147; African, N = 122,571; Latin American, N = 38,962; East Asian, N = 13,551; and South Asian, N = 1,716 ancestries). We observed a high degree of cross-ancestral similarity in the genetic architecture of PAU and identified 110 independent risk variants in within- and cross-ancestry analyses. Cross-ancestry fine mapping improved the identification of likely causal variants. Prioritizing …

Evaluating Differences In Optical Properties Of Indolent And Aggressive Murine Breast Tumors Using Quantitative Diffuse Reflectance Spectroscopy, Joel Rodriguez Troncoso, Umme Marium Mim, Jesse D. Ivers, Santosh K. Paidi, Mason G. Harper, Khue G. Nguyen, Sruthi Ravindranathan, Lisa Rebello, David E. Lee, David A. Zaharoff, Ishan Barman, Narasimhan Rajaram

Biomedical Engineering Faculty Publications and Presentations

We used diffuse reflectance spectroscopy to quantify tissue absorption and scattering-based parameters in similarly sized tumors derived from a panel of four isogenic murine breast cancer cell lines (4T1, 4T07, 168FARN, 67NR) that are each capable of accomplishing different steps of the invasion-metastasis cascade. We found lower tissue scattering, increased hemoglobin concentration, and lower vascular oxygenation in indolent 67NR tumors incapable of metastasis compared with aggressive 4T1 tumors capable of metastasis. Supervised learning statistical approaches were able to accurately differentiate between tumor groups and classify tumors according to their ability to accomplish each step of the invasion-metastasis cascade. We investigated …

An Ace2 Decamer Viral Trap As A Durable Intervention Solution For Current And Future Sars-Cov, Hailong Guo, Bomsoo Cho, Paul R Hinton, Sijia He, Yongjun Yu, Ashwin Kumar Ramesh, Jwala Priyadarsini Sivaccumar, Zhiqiang Ku, Kristen Campo, Sarah Holland, Sameer Sachdeva, Christopher Mensch, Mohamed Dawod, Annalis Whitaker, Philip Eisenhauer, Allison Falcone, Rebekah Honce, Jason W Botten, Stephen F Carroll, Bruce A Keyt, Andrew W Womack, William R Strohl, Kai Xu, Ningyan Zhang, Zhiqiang An, Sha Ha, John W Shiver, Tong-Ming Fu

Faculty, Staff and Student Publications

The capacity of SARS-CoV-2 to evolve poses challenges to conventional prevention and treatment options such as vaccination and monoclonal antibodies, as they rely on viral receptor binding domain (RBD) sequences from previous strains. Additionally, animal CoVs, especially those of the SARS family, are now appreciated as a constant pandemic threat. We present here a new antiviral approach featuring inhalation delivery of a recombinant viral trap composed of ten copies of angiotensin-converting enzyme 2 (ACE2) fused to the IgM Fc. This ACE2 decamer viral trap is designed to inhibit SARS-CoV-2 entry function, regardless of viral RBD sequence variations as shown by …

Enhanced Tp53 Reactivation Disrupts Myc Transcriptional Program And Overcomes Venetoclax Resistance In Acute Myeloid Leukemias, Yuki Nishida, Jo Ishizawa, Edward Ayoub, Rafael Heinz Montoya, Lauren B Ostermann, Muharrem Muftuoglu, Vivian R Ruvolo, Tallie Patsilevas, Darah A Scruggs, Shayaun Khazaei, Po Yee Mak, Wenjing Tao, Bing Z Carter, Steffen Boettcher, Benjamin L Ebert, Naval G Daver, Marina Konopleva, Takahiko Seki, Kensuke Kojima, Michael Andreeff

Faculty, Staff and Student Publications

The tumor suppressor TP53 is frequently inactivated in a mutation-independent manner in cancers and is reactivated by inhibiting its negative regulators. We here cotarget MDM2 and the nuclear exporter XPO1 to maximize transcriptional activity of p53. MDM2/XPO1 inhibition accumulated nuclear p53 and elicited a 25- to 60-fold increase of its transcriptional targets. TP53 regulates MYC, and MDM2/XPO1 inhibition disrupted the c-MYC-regulated transcriptome, resulting in the synergistic induction of apoptosis in acute myeloid leukemia (AML). Unexpectedly, venetoclax-resistant AMLs express high levels of c-MYC and are vulnerable to MDM2/XPO1 inhibition in vivo. However, AML cells persisting after MDM2/XPO1 inhibition exhibit a …

The Endoparasite Fauna Of Mesopredatory Mesopelagic Teleosts, Alexander U. Rayburn

All HCAS Student Capstones, Theses, and Dissertations

The ecology of the mesopelagic zone is an understudied area of the open ocean, with few diet studies even for dominant fish species. Since endoparasites are generally transmitted trophically, descriptions of the parasite communities within fishes can often provide additional insights on food web interactions. This project assesses the endoparasite faunal community of mesopredatory mesopelagic teleosts to better understand mesopelagic food webs in the South Atlantic Bight. Fishes in the Families Alepisauridae (lancetfishes), Gempylidae (snake mackerels), Bramidae (pomfrets), and Scombrolabracidae (longfin escolar) are frequent bycatch in the pelagic longline fishery targeting swordfish Xiphias gladius and thunnid tunas, yet the ecology …

Clinician Perspectives On Technology-Enhanced In Vivo Exposures During Prolonged Exposure Therapy For Ptsd, Delisa G Brown, Amber M Jarnecke, Tanya C Saraiya, Elizabeth Santa-Ana, Ron Acierno, Mclain Reese, Robert Adams, William Harley, Sudie E Back

Faculty, Staff and Student Publications

Objective: To investigate clinicians' perceptions regarding the use of mobile technology tools during prolonged exposure (PE) therapy to allow for monitoring and enhancing in-vivo exposures (IVEs).

Methods: Clinicians with training in PE therapy (N = 32; average of 9 years of practice) completed surveys asking about their perspectives on the utility of virtually attending IVEs with patients while simultaneously having access to real-time subjective and physiological data (i.e., heart rate, galvanic skin conductance) to guide exposure exercises and assure optimal stimulus engagement.

Results: Findings showed clinicians to have a favorable view of applying technology devices and systems to enhance IVEs …

Senior Recital: Grace Gatto, Saxophone; Lu Witzig, Piano; December 1, 2023, Grace Gatto, Lu Witzig

School of Music Programs

Kemp Recital Hall
December 1, 2023
Friday Evening
6:30 p.m.

Sleep Duration, Sleep Quality, And Weapon Carrying In A Sample Of Adolescents From Texas, Arthur Stefanski, Eduardo Pérez-Palma, Tobias Brünger, Ludovica Montanucci, Cornelius Gati, Chiara Klöckner, Katrine M Johannesen, Kimberly Goodspeed, Marie Macnee, Alexander T Deng, Ángel Aledo-Serrano, Artem Borovikov, Maina Kava, Arjan M Bouman, M J Hajianpour, Deb K Pal, Marc Engelen, Eveline E O Hagebeuk, Marwan Shinawi, Alexis R Heidlebaugh, Kathryn Oetjens, Trevor L Hoffman, Pasquale Striano, Amanda S Freed, Line Futtrup, Thomas Balslev, Anna Abulí, Leslie Danvoye, Damien Lederer, Tugce Balci, Maryam Nabavi Nouri, Elizabeth Butler, Sarah Drewes, Kalene Van Engelen, Katherine B Howell, Jean Khoury, Patrick May, Marena Trinidad, Steven Froelich, Johannes R Lemke, Jacob Tiller, Amber N Freed, Jing-Qiong Kang, Arthur Wuster, Rikke S Møller, Dennis Lal

Faculty, Staff and Student Publications

Genetic variants in the SLC6A1 gene can cause a broad phenotypic disease spectrum by altering the protein function. Thus, systematically curated clinically relevant genotype-phenotype associations are needed to understand the disease mechanism and improve therapeutic decision-making.

We aggregated genetic and clinical data from 172 individuals with likely pathogenic/pathogenic (lp/p) SLC6A1 variants and functional data for 184 variants (14.1% lp/p). Clinical and functional data were available for a subset of 126 individuals. We explored the potential associations of variant positions on the GAT1 3D structure with variant pathogenicity, altered molecular function and phenotype severity using bioinformatic approaches.

The GAT1 transmembrane domains …

Endohepatology In Clinical Practice: Eus-Guided Portal Pressure Measurement Combined With Eus-Guided Liver Biopsy And Variceal Screening And Treatment In Outpatients, Sung Kim, Scot Lewey, Laura Meuller, Douglas G. Adler

Student Publications

Background and Objectives

EUS-guided portal pressure gradient (PPG) is a novel technique that permits a true, direct measure of portal vein pressure and hepatic vein pressure. This article details our experience and lessons learned from 20 consecutive outpatient EUS-PPG procedures performed at a single center, along with simultaneous EUS-guided liver biopsy, variceal screening, and variceal banding.

Methods

Data on the first 20 patients who underwent EUS-PPG at a single center were retrospectively viewed and analyzed. The effects of various liver diseases or other patient-related factors on the clinical and technical success of EUS-PPG measurements, as well as EUS-guided liver biopsy …

Community-Wide Versus School-Based Targeted Deworming For Soil-Transmitted Helminth Control In School-Aged Children In Vietnam: The Code-Sth Cluster-Randomised Controlled Trial, Cef Dyer, D Ng-Nguyen, Ne Clarke, Sf Hii, Et Al

Peninsula Medical School

Summary Background Soil-transmitted helminth (STH) infection control programs typically consist of school-based preventive chemotherapy (PC) targeted to school-aged children. STH reservoirs in untreated community members contribute to ongoing transmission in children. The CoDe-STH (Community Deworming against STH) trial, conducted in Dak Lak province, Vietnam, between October 2019 and November 2020, aimed to determine whether community-wide mass drug administration (MDA) is more effective than school-based targeted PC in reducing STH prevalence and intensity in children. Methods In this two-arm cluster randomised controlled trial, 64 primary schools were randomly assigned 1:1 to receive either school-based targeted PC (“school arm”) or community-wide MDA …

Wastewater Treatment Plants: The Missing Link In Global One-Health Surveillance And Management Of Antibiotic Resistance, Abdolmajid Gholizadeh, Mehdi Khiadani, Maryam Foroughi, Hadi Alizade Siuki, Hadi Mehrfar

Research outputs 2022 to 2026

Introduction: As a global public health crisis, antibiotic resistance (AR) should be monitored and managed under the One-Health concept according to the World Health Organization (WHO), considering the interconnection between humans, animals, and the environment. But this approach often remains focused on human health and rarely on the environment and its compartments, especially wastewater as the main AR receptor. Wastewater treatment plants (WWTPs) not only are not designed for reliving AR but also provide appropriate conditions for enhancing AR through different mechanisms. Methods: By reviewing the research-based statistics on the inclusion of WWTPs in the One-Health/AR program crisis, this paper …