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A New Hypothesis Describing The Pathogenesis Of Oral Mucosal Injury Associated With The Mammalian Target Of Rapamycin (Mtor) Inhibitors, Alessandro Villa

All Publications

It has been 24 years since rapamycin (sirolimus) was approved to mitigate solid organ transplant rejection and 16 years since mTOR (mammalian/mechanistic target of rapamycin) inhibitors reached patients as a cancer therapy. While the clinical benefits of mTOR inhibitors (mTORi) are robust, so too are their toxicities. Among the most common issues is the development of ulcers of the oral mucosa (mTOR-inhibitor associated stomatitis; mIAS). These lesions are distinct from those of other anti-cancer agents, occur with regularity, and impact patient outcomes. mIAS' pathogenesis has been the subject of speculation, and its similar presentation to recurrent aphthous stomatitis (RAS) has …

Investigation Of The Deubiquitinating Enzyme Usp7 In The Brain, Hao Chen

Arts & Sciences Graduate Student Theses and Dissertations

The development of the nervous system relies on precise control of protein ubiquitination and degradation. Consequently, imbalance in the ubiquitin signaling network is believed to have significant implications for neurological disorders. Recent research has not only detailed the various functions of different ubiquitin ligases in neural development, but has also disclosed the role of deubiquitinating enzyme as an additional regulatory dimension in the ubiquitin signaling network. Specifically, deletion or mutation of the deubiquitinating enzyme USP7 causes the Hao-Fountain syndrome, characterized by developmental delay, intellectual disability, autism, and aggressive behavior. Although USP7 has been studied in proliferating cells in the context …

“Was Thanos Right?”: Mad Genius, Eugenics, And Popular Culture, Bj Bruther

The North Meridian Review

No abstract provided.

The Witness Of Trees: Creative Essay, Marijean Wegert

The North Meridian Review

No abstract provided.

Our Sacred Underground: Fiction, Marc Alexander Valle

The North Meridian Review

No abstract provided.

Don Faggot: Fiction, Ricardo Quintana-Vallejo

The North Meridian Review

No abstract provided.

Contributor Bios, North Meridian Review Staff

The North Meridian Review

No abstract provided.

Full, North Meridian Review Staff

The North Meridian Review

No abstract provided.

Woulda, Coulda, Shoulda: How Virginia’S Everchanging Politics Creates (Missed) Opportunities For Major Policy Decisions, Carlos Hopkins, Abigail Thompson

Richmond Public Interest Law Review

Benjamin Franklin may have been discussing the new United States

Constitution when he penned this note to his friend, French scientist Jean-

Baptiste Le Roy, but he could easily have been referring to politics in

Virginia. Virginia House of Delegates members and members of the

Congressional House of Representatives serve two-year terms. Members of

the Virginia Senate serve four-year terms. United States Senators serve sixyear

terms. And the Governor, Lieutenant Governor and Attorney General

all serve four-year terms with only the Governor constitutionally limited to a

single four-year term. With all of these terms being staggered across the

various offices, …

Liz Lochhead And The Fairies: Context And Influence In Grimm Sisters And Dreaming Frankenstein, William Donaldson

Studies in Scottish Literature

Examines the Scottish poet Liz Lochhead's period of North American travel and her response to American second-wave feminist poetics, particularly to the anthology No More Masks! (1973) and the poetry of Adrienne Rich and Anne Sexton, the treatment of myth by J.G. Frazer and Robert Graves, and the perspective on Scottish fairy tales offered by folklorists, to explore Lochhead's creative reworking of both fairy tale and classical myth in her collections Grimm Sisters (1981) and Dreaming Frankenstein (1984).

Are Human-Like Robots Trusted Like Humans? An Investigation Into The Effect Of Anthropomorphism On Trust In Robots Measured By Expected Value As Reflected By Feedback Related Negativity And P300, Lucy Olivia Wilson

The Plymouth Student Scientist

Robots are becoming more prevalently used in industry and society. However, in order to ensure effective use of the trust, must be calibrated correctly. Anthropomorphism is one factors which is important in trust in robots (Hancock et al., 2011). Questionnaires and investment games have been used to investigate the impact of anthropomorphism on trust, however, these methods have led to disparate findings. Neurophysiological methods have also been used as an implicit measure of trust. Feedback related negativity (FRN) and P300 are event related potential (ERP) components which have been associated with processes involved in trust such as outcome evaluation. This …

Assessing The Spatial And Temporal Distribution Of Microplastics Within The Sediment Of Plymouth Sound, Keira N. Lintin

The Plymouth Student Scientist

The pollution of microplastics in the marine environment is a growing issue that impacts us globally. These invasive particles have been discovered in all regions of the world, including human body tissue. It is well understood that microplastics settle within seafloor sediment and hotspots are found close to human activity. However, the way microplastics are distributed both spatially and temporally in urban marine environments, and why this might be, is little known. Using the ‘primary analytical process’, a study was conducted in Plymouth Sound, United Kingdom, to assess how microplastics were distributed within the sediment here. General sediment samples and …

Bat Activity And Diversity In Plymouth’S Green Spaces: Implications For Future Conservation And Management, Ellie Hawcutt

The Plymouth Student Scientist

Urbanisation and human population growth is a threat to biodiversity at a global scale. Bats in urban green areas are becoming increasingly acknowledged within the literature as we begin to understand their importance as useful bioindicators. Bat activity and diversity was examined through passive acoustic monitoring of four sites in Plymouth (UK) during October 2022 (Central Park, Ham Wood, Radford Lake, Saltram Park). This was completed to compare sites with differing percentages of habitats, and make implications for the future management of urban green spaces to benefit bats. Basic habitat surveys of each site were undertaken, estimating the percentage of …

Testing The Potential Use Of Uk Wetland Plant Species In Paludiculture Using Examples From The Somerset Levels, Olivia Bentley

The Plymouth Student Scientist

The trade-off between economic benefits and environmental sustainability results in the unsustainable use of wetlands through conversion to agricultural land. As a result, causing peat degradation, reducing the ecosystem’s capacity to provide ecosystem services. Paludiculture, the concept of cultivating wetland plant species in rewetted conditions that can be converted and utilised commercially, presents an opportunity to harmonise economic stability and environmental protection. However, most research into paludiculture has been conducted in continental Europe; there is a knowledge gap regarding paludiculture in the UK. In this research, seven UK wetland plant species were harvested from the Somerset Levels, a low-lying wetland …

The Role Of Colony Morphology And Substratum Inclination On The Distribution Of Eunicella Verrucosa On Shallow Reefs, Luke Thompson

The Plymouth Student Scientist

Eunicella verrucosa plays an important role in shallow reefs, where they produce a complex 'sheet tree' morphology that supports a variety of benthic-dwelling organisms. E. verrucosa is considered 'vulnerable' by the IUCN Red List, which validates the importance of understanding the biotic and abiotic factors influencing the species morphology and survival. This study analyses how horizontal and vertical slope inclinations influence colony morphology. A population of 115 E. verrucosa colonies were observed at Plymouth's inner breakwater fort at 8–13.8m in depth. The influence of inclination on morphology was investigated by observing colony height, encrusting branch diameter and branch complexity for …

Diversity, Abundance, And Distribution Of Ground Invertebrates In Lower Sharpham Farm, Valeria Zavala Quiroga

The Plymouth Student Scientist

Invertebrates constitute the largest group of animals on Earth and represent the bulk of biodiversity. They are responsible for numerous essential ecosystems services and are at the centre of many terrestrial food webs. Due to habitat loss from land use change and conversion to intensive agriculture, they are experiencing a substantial decline in biodiversity, hence conservation approaches such as rewilding have been sought. There are limited studies of invertebrate biodiversity in rewilding projects, therefore the aim of this study is to investigate the diversity and abundance of ground invertebrates at Lower Sharpham Farm and the influences of vegetation structure in …

The Different Factors Affecting Chiroptera Emergences With A Focus On Pipistrellus Pipistrellus And Pipistrellus Pygmaeus, Hannah Mccabe

The Plymouth Student Scientist

Chiroptera (bats) are important within different ecosystems and biomes due to the different ecosystem services that they provide. The services that they provide to the United Kingdom include organic agricultural pest control and worldwide bats provide pollination and seed dispersal. The rationale for this study is to understand emergence preferences based on natural and anthropogenic factors such as building structure, habitats, and time. Bat roosts are species specific, with urban exploiter species relying on urban habitats such as Pipistrellus pipistrellus and urban-adapter species such as Nyctalus noctule relying on natural roosts. A range of surveys sites were studied across, Hampshire …

The Function Of Ask1 In Sepsis And Stress-Induced Disorders, John Kostyak, Steven Mckenzie, Ulhas Naik

Cardeza Foundation for Hematologic Research

Apoptosis signal-regulating kinase 1 (ASK1) is a serine-threonine kinase that is ubiquitously expressed in nucleated cells and is responsible for the activation of multiple mitogen-activated protein kinases (MAPK) to regulate cell stress. Activation of ASK1 via cellular stress leads to activation of downstream signaling components, activation of transcription factors, and proinflammatory cytokine production. ASK1 is also expressed in anucleate platelets and is a key player in platelet activation as it is important for signaling. Interestingly, the mechanism of ASK1 activation is cell type-dependent. In this review we will explore how ASK1 regulates a variety of cellular processes from innate immune …

Adjuvant Pluronic F68 Is Compatible With A Plant Root-Colonizing Probiotic, Pseudomonas Chlororaphis O6, Amanda R. Streeter, Anthony Cartwright, Mohammad Zargaran, Anagha Wankhade, Anne J. Anderson, David W. Britt

Biological Engineering Faculty Publications

Plant probiotic bacteria are being increasingly used to maximize both the productivity and quality of field crops. Pseudomonas chlororaphis O6 (PcO6) is a plant root colonizer with probiotic activities. This bacterium produces an array of metabolites, including a group of phenazines that are functional in plant protection. The paper reports responses of PcO6 to a nonionic triblock copolymer surfactant, Pluronic F68. This Pluronic exhibits membrane "healing" activity and improves cryopreservation recovery in eukaryotic cells. The product is FDA-approved and is applied as an adjuvant in formulations used in agriculture, medicine, and biotechnology. Growth of PcO6 on …

This Land Is Our Land: Tree Planting And Environmental Construction On The Nebraska Prairie, Megan Sue Launchbaugh

History Theses, Dissertations, and Student Creative Activity

In 1895 the Nebraska Legislature passed a bill officially adopting the nickname the “Tree Planter’s State” on account of the founding of Arbor Day, the Timber Culture Act of 1873, and the “millions of trees planted by early settlers as windbreaks, woodlots, and orchards.” Since that time, Arbor Day and the Timber Culture Act have been the subject of countless historical studies, while the subject of settler tree planting remains largely unexplored. This thesis seeks to begin establishing a place for the stories, experiences, and legacy of settler tree planting within the regional narrative by examining the cultural, physical, and …

“Storm Of Insanity”: The Chaotic Nature Of Relief Work And Financial Compensation Following The Johnstown Flood Of 1889, Carly N. Marze

History Theses, Dissertations, and Student Creative Activity

On May 31, 1889, the South Fork dam ruptured, and the resulting wall of water pummeled through the small town of Johnstown, Pennsylvania, killing over 2,000 people. The cause was negligence by the dam’s proprietors at the South Fork Fishing & Hunting Club. As bodies lay scattered throughout the Conemaugh Valley and Johnstown sat nearly twenty-feet deep in mud and debris, two questions arose: What relief work should be done to restore Johnstown? And how should this relief be financed? Lack of resources and the urgency of the work created a chaotic atmosphere in which constantly shifting procedures and disputes …

Para-Infectious Brain Injury In Covid-19 Persists At Follow-Up Despite Attenuated Cytokine And Autoantibody Responses, Benedict D Michael, Cordelia Dunai, Edward J Needham, Kukatharmini Tharmaratnam, Robyn Williams, Yun Huang, Sarah A Boardman, Jordan J Clark, Parul Sharma, Krishanthi Subramaniam, Greta K Wood, Ceryce Collie, Richard Digby, Alexander Ren, Emma Norton, Maya Leibowitz, Soraya Ebrahimi, Andrew Fower, Hannah Fox, Esteban Tato, Mark A Ellul, Geraint Sunderland, Marie Held, Claire Hetherington, Franklyn N Egbe, Alish Palmos, Kathy Stirrups, Alexander Grundmann, Anne-Cecile Chiollaz, Jean-Charles Sanchez, James P Stewart, Michael Griffiths, Tom Solomon, Gerome Breen, Alasdair J Coles, Nathalie Kingston, John R Bradley, Patrick F Chinnery, Jonathan Cavanagh, Sarosh R Irani, Angela Vincent, J Kenneth Baillie, Peter J Openshaw, Malcolm G Semple, Covid-Cns Consortium, Isaric4c Investigators, Leonie S Taams, David K Menon

Faculty, Staff and Student Publications

To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1-11 days post-admission) and 92 convalescent sera (56 with COVID-19-associated neurological diagnoses). Here we show that compared to 60 uninfected controls, tTau, GFAP, NfL, and UCH-L1 are increased with COVID-19 infection at acute timepoints and NfL and GFAP are significantly higher in participants with neurological complications. Inflammatory mediators (IL-6, IL-12p40, HGF, M-CSF, CCL2, and IL-1RA) are associated with both altered consciousness and markers of brain injury. Autoantibodies are more common …

Mechanisms And Prevention Of Antibiotic Resistant Organism Spread In Hospitals, Erin P. Newcomer

McKelvey School of Engineering Graduate Student Theses & Dissertations

Our quest as a species to treat and prevent disease has led us to develop medical care that would have been inconceivable even one century ago. However, as we learn to overcome previous roadblocks, new hurdles that we hadn’t even considered continue to present themselves. Once we learned to understand the germ theory of disease, we sought treatments for infectious diseases, which led us to the development of antibiotics. Antibiotics are responsible for saving countless lives and have ushered in the advances in other fields of medicine like cancer treatment and surgery. Now, antibiotic resistance threatens our ability to treat …

The Development And Validation Of Novel Imaging Biomarkers For Uterine Contraction, Cervix And Placenta In Pregnancy, Wenjie Wu

McKelvey School of Engineering Graduate Student Theses & Dissertations

Annually, nearly half a million neonates in the United States and 15 million globally are born preterm, defined as prior to 37 completed weeks of gestation. These births present elevated risks of neonatal mortality and long-term neurological deficits. The predominant obstetric precursors of preterm birth (PTB) include spontaneous preterm labor (45%), medically-indicated deliveries (30%), and preterm premature rupture of membranes (PPROM, 25%). Each precursor is associated with distinct physiological or structural alterations such as uterine contractions, placental dysfunction, or cervical insufficiency. Current methodologies for monitoring uterine contractions, such as intrauterine pressure catheters and electrohysterography, possess limitations in spatial resolution, coverage, …

Variables Affecting The Extraction Of Antioxidants In Cold And Hot Brew Coffee: A Review, Brian Yust, Frank Wilkinson, Niny Rao

College of Life Sciences Faculty Papers

Coffee beans are a readily available, abundant source of antioxidants used worldwide. With the increasing interest in and consumption of coffee beverages globally, research into the production, preparation, and chemical profile of coffee has also increased in recent years. A wide range of variables such as roasting temperature, coffee grind size, brewing temperature, and brewing duration can have a significant impact on the extractable antioxidant content of coffee products. While there is no single standard method for measuring all of the antioxidants found in coffee, multiple methods which introduce the coffee product to a target molecule or reagent can be …

Technology And Mental Health Counseling, Hanna Cespedes, Elizabeth Robey, Tyler Wilkinson

Journal of Technology in Counselor Education and Supervision

The use of technology in the field of mental health has been an increasing interest of study and utilization in recent years, especially during and after the Covid 19 pandemic in which social distancing practices were encouraged to limit the spread of the virus. During this time, the use of technology for health-related appointments became vital as many offices shut down and/ or had limited in-person access. Furthermore, technology has already been integrated and researched significantly in other areas of the healthcare fields such as psychiatry and nursing. However, there is a lack of understanding of the role of technology …

Full Issue

The Thetean: A Student Journal for Scholarly Historical Writing

No abstract provided.

Perpetuated Inferiority, Kristine Ashton

The Thetean: A Student Journal for Scholarly Historical Writing

Nineteenth-century schools taught more than reading, writing, and arithmetic. They were expected to convey patriotism and civic responsibility and to mold moral character. While publishers designed textbooks to teach children to spell and to read, they also inculcated the books with social values through word choice and lesson plans. The printers, journalists, teachers, and ministers who wrote the schoolbooks selectively filled their pages with political, economic, social, and moral concepts that shaped children's views of their nation's past and their position within the present society.

The Meanings Of The Millennium, Bernard J. Mcginn

The Thetean: A Student Journal for Scholarly Historical Writing

As we approach the year 2000-2001 of what we now ecumenically term the Common Era words like millennium and apocalypse seem to meet us everywhere. Millennial madness, as I call it, may be in large part a media event, but no age in Western history has lacked for those who believed that the end of history, which is what the word apocalypse signifies for most people, was near. While apocalypse conjures up images of dread and destruction in most minds, the history of the broader phenomenon of apocalypticism in Christianity, Judaism, and Islam, has always been an intricate fusion of …

Gettin' By, Kam Brian

The Thetean: A Student Journal for Scholarly Historical Writing

Utah was severely affected by the Great Depression of the 1930's. Unemployment soared and thousands were forced to turn to the government for assistance. Yet, Wayne county, a small area in south central Utah was able to escape many of the devastating effects brought on by the failing economy. The residents of this isolated county eluded much of the despair and disillusionment felt throughout the country at this time. Alta Albrecht, a life-long resident of Wayne County, recalls the period like this, "People didn't have much, they didn't know the difference. They didn't expect much, but they were happy people."