Digital Commons Network^™

Synthesis Of Glucomannan-Xylan Composite Biofilms: Characterization And Applications For Food Packaging, Kholoud Al-Ajlouni

Dissertations

Scientists are most concerned about the need for green alternatives for efficient food packaging polymers to replace petroleum-based packaging products. The waste of corn cobs and the roots of the konjac plant contain hemicellulose, xylan and glucomannan respectively, and can be used to produce biofilms for food packaging.

The aim of these studies is to formulate biofilms from glucomannan-xylan blends that compete with petroleum-based plastic wrap. The biofilms must be strong, smooth, transparent, have a water vapor barrier, have the required mechanical properties and be cheap. Biofilms from glucomannan were stiff, lacked mechanical properties, and absorbed moisture. Therefore, it reacts …

An Island Of Sanity During Covid-19 Pandemic: Does Pet Attachment Support Buffer Employees' Stress Due To Job Insecurity?, Min Maggie Wan, Thomas K. Kelemen, Yejun Zhang, Samuel H. Matthews

Management Faculty Publications

Drawing on the transactional theory of stress, the current study investigates whether employee job insecurity triggers employee behavioral strain reactions (i.e., alcohol use, marijuana use, and cigarette use) and psychological strain reactions (i.e., emotional exhaustion and depression) through stress during the COVID-19 pandemic. In addition, we integrate social support theory and expect the moderating role of pet attachment support in the above relationships. By collecting two-wave data from 187 employees with pets in the United States, we found that during the COVID-19 pandemic, stress mediated the relationships between job insecurity and predicted behavioral and psychological reactions. Moreover, pet attachment support …

Biochemical And Kinetic Analysis Of Phosphofructokinase In The Eukaryotic Human Pathogen Entamoeba Histolytica, Jin Cho

All Dissertations

Entamoeba histolytica is a water- and food-borne intestinal parasite that causes amoebiasis and liver abscess in ~100 million people each year leading to ~100,000 deaths. This amitochondriate parasite lacks many metabolic pathways including the tricarboxylic acid cycle and oxidative phosphorylation, and cannot synthesize purines, pyrimidines, or most amino acids. As a result, E. histolytica is presumed to rely on its modified pyrophosphate (PP_i)-dependent glycolytic pathway for ATP production during growth on glucose. This pathway relies on a PP_i-dependent rather than ATP-dependent phosphofructokinase (PFK) and thus has a net production of three ATP per glucose. However, in …

Structural Characterization Of Cardiomyocyte Microenvironment In Murine Myocardium By Multimodal Stimulated Emission Depletion Microscopy, Zhao Zhang

All Dissertations

Cardiomyopathy, a disease of the heart muscle, is characterized by structural and functional abnormalities of the myocardium, in the absence of coronary artery disease, hypertension, valvular disease or congenital heart disease. In 2020, there were approximately 6.11 million prevalent cases of cardiomyopathy and myocarditis, and 0.37 million related deaths worldwide. Many affected individuals are asymptomatic, and chronically treated patients are at risk of heart failure. Within the myocardium, cardiomyocytes reside in a complex and dynamic extracellular matrix (ECM), consisting of basement membrane and interstitial matrix. The interactions between cardiomyocytes and myocardial ECM play a critical role in maintaining cardiac geometry …

A Digital Triplet For Utilizing Offline Environments To Train Condition Monitoring Systems For Rolling Element Bearings, Ethan Wescoat

All Dissertations

Manufacturing competitiveness is related to making a quality product while incurring the lowest costs. Unexpected downtime caused by equipment failure negatively impacts manufacturing competitiveness due to the ensuing defects and delays caused by the downtime. Manufacturers have adopted condition monitoring (CM) techniques to reduce unexpected downtime to augment maintenance strategies. The CM adoption has transitioned maintenance from Breakdown Maintenance (BM) to Condition-Based Maintenance (CbM) to anticipate impending failures and provide maintenance actions before equipment failure. CbM is the umbrella term for maintenance strategies that use condition monitoring techniques such as Preventive Maintenance (PM) and Predictive Maintenance (PdM). Preventive Maintenance involves …

Engineering Next-Generation Cardiovascular Therapies, Ryan Walker Barrs

All Dissertations

Cardiovascular diseases are the leading cause of death worldwide. Heart disease, in particular, accounted for 1 in every 5 deaths in the United States in 2021, representing a substantial public health burden that will require more effective treatment options to alleviate. Heart transplant surgery is currently the only option to completely restore cardiac function, but many patients die while waiting for a transplant due to a longstanding organ donor shortage. Thus, there is a dire need for accessible treatment options that can repair damaged hearts. Recent advances in tissue engineering and regenerative medicine have accelerated the development of therapies for …

Experimental And Computational Platforms For Studying Systems Mechanobiology, Brendyn Miller

All Dissertations

Mechanical stimulation through physical activity has been shown to play an important role in treating and preventing several non-communicable diseases such as hypertension, lower back pain (LBP), type-2 diabetes mellitus, and several cancers. This is accomplished through the regulation of cellular behavior and tissue remodeling within the body at both the micro- and macro-scale levels. The goal of mechanobiology research is to gain in-depth knowledge and understanding of how cells sense physical forces in conjunction with other biochemical cues and translate those factors into important biological functions that either maintain tissue homeostasis or lead to pathological states. Understanding these processes …

Cellular Mechanism Of Pentagalloyl Glucose-Mediated Prevention And Reversal Of Abdominal Aortic Aneurysms, Greg Halsey

All Dissertations

Abdominal aortic aneurysm (AAA) has been the 15th leading cause of death in persons older than 55 for the past ten years in several Western countries, with rupture resulting in an almost 100% mortality rate. AAA is a focal dilation of the aorta characterized by progressive loss of elastin and vascular smooth muscle cells (SMCs), as well as persistent inflammatory response [1]. The only treatment for AAA is surgery; however, the mortality post-procedure is still 1-4%, with a 15-30% chance of morbidity [2].

Pentagalloyl glucose (PGG) treatment is effective in the reversal of AAA. While its stabilizing interactions with extracellular …

Addressing Mercury Contamination From Artisanal Gold Mining In Colombia: Pollution Exposure, Health Risk, And Educational Efforts In The Communities Of La Toma, Colombia, Kelli Mccourt

All Dissertations

Artisanal and small-scale gold mining (ASGM) has become a primary environmental and public health concern in the region of Colombia known as Alto Cauca. The predominantly Afro-descendent communities of Yolombó and La Toma in Alto Cauca have experienced pollution linked to the use of mercury in the ASGM process. For the past decade, mercury has emerged as a contaminant of increasing concern in the communities due to its toxicity and ability to bioaccumulate and biomagnify. Likewise, mining in the region raises concerns over the leaching of metals into local waters. Given the complexity of risk and pollution in the communities, …

Characterization Of The Effects Of The Pyrazolopyrimidine Inhibitor Grassofermata (Nav-2729) In The Eukaryotic Pathogen Trypanosoma Brucei, Kristina Marie Parman

All Dissertations

The protozoan pathogen, Trypanosoma brucei, is the causative agent of sleeping sickness in humans and nagana in livestock in sub-Saharan Africa. T. brucei cycles between tsetse fly and mammalian hosts, and it is adapted to survive in diverse host tissues. Variant Surface Glycoprotein (VSG) plays a key role in immune evasion in the mammalian host. The VSG membrane anchor requires two myristates, 14-carbon saturated fatty acids (FAs) that are scarce in the host. T. brucei can synthesize FAs de novo, but also readily takes up exogenous FAs, despite lacking homologs to fatty acid uptake proteins found in other …

Influence Of Photoreactor Design Parameters On The Performance Of Ultraviolet Light-Induced Degradation Of Per-And Polyfluoroalkyl Substances By Bismuth Oxy Hydroxy Phosphate And Hexagonal Boron Nitride Photocatalystsinfluence Of Photoreactor Design Parameters On The Performance Of Ultraviolet Light-Induced Degradation Of Per-And Polyfluoroalkyl Substances By Bismuth Oxy Hydroxy Phosphate And Hexagonal Boron Nitride Photocatalysts, Mojtaba Qanbarzadeh

All Dissertations

The main objective of this study is to evaluate the practical applicability of heterogeneous photocatalysis technology powered by ultraviolet (UV) photons for the degradation of per and -polyfluoroalkyl substances (PFAS) in contaminated groundwater samples. For this purpose, bismuth oxyhydroxy phosphate (BOHP) and hexagonal boron nitride (hBN) were utilized as the main photocatalysts in slurry photodegradation systems. BOHP (Bi₃O(OH)(PO₄)₂) is a wide bandgap semiconductor with high activity for degrading long-chain perfluorocarboxylic acids (PFCAs) in mild operational conditions. Boron nitride (BN) is another wide bandgap semiconductor material that was used in this study due to its …

Citrate Hydrogels For Regenerative Medicine Applications, Mark Pitman

All Dissertations

Regenerative medicine focuses on restoring cells and tissues to re-establish proper function. Hydrogels are a customizable and adaptable set of materials that can be engineered as tools for regenerative medicine. My research has focused on developing and applying biomaterials to spinal cord injury and chronic wounds. Spinal cord injury and chronic wounds share pathophysiological issues with oxidative stress, excess free, and macrophage polarization. Furthermore, both conditions lack robust, effective treatments. We hypothesized that citrate hydrogels – hydrogels that contain citric acid as a functional component – would provide radical scavenging and iron chelation that would benefit both conditions. The hydrogels …

Integrated Techniques To Identify And Characterize Resistance To Fusarium Wilt Caused By Fusarium Oxysporum, F. Sp. Vasinfectum Race 4 In Two Domesticated Gossypium Species, Stephen Parris

All Dissertations

Fusarium wilt of cotton (Gossypium hirsutum and G. barbadense), caused by Fusarium oxysporum f. sp. vasinfectum race 4 (FOV4), is the most threatening disease faced by today’s cotton breeders. During the past 20 years, over $7 million have been dedicated to efforts in breeding upland cotton for resistance to FOV4 while yielding little to no results. To counteract this, we conducted a study in Clint, TX, that utilized control plots and geostatistical methods to adjust phenotypic data for the heterogeneous distribution of FOV4 in the field, improving the accuracy of genetic resistance assessments. Concurrently, early-generation genetic mapping in …

The Developmental Process For Adenoviral Vectored Canine Influenza Vaccines, Nicholas Jeanjaquet

School of Biological Sciences: Dissertations, Theses, and Student Research

Canine Influenza Virus (CIV) is a recently emerged branch of Influenza A virus that is highly infectious in dogs. The first strain was isolated in 2003, and it has quickly become endemic in areas with dense dog populations, most notably in Asia. The proximity of dogs to humans, along with their potential to serve as mixing vessels for reassortment, raises concern for possible zoonotic transmission and a potential human pandemic. Available vaccines are not frequently updated and struggle to prevent the spread of currently circulating strains. This highlights the need for a new and more effective vaccine. We outline the …

Real But Fictional: A Research Agenda Of Virtual Influencers For Brand Communications In Social Media Marketing, Lei Huang

Journal of Applied Marketing Theory

With the rise of virtual influencers (VIs) and their impacts on influencer marketing, this paper proposes a future research paradigm on how to develop brand communication strategies through a novel understanding of VIs from both the consumer and company perspectives. Built on the parasocial interaction theory and the human brand theory, six propositions aim to provide research guidelines for influencer and social media marketing by leveraging the use of VIs in a brand-consumer relationship. The theoretical and managerial implications are also discussed.

Music With A Racial Nexus: Culture Clash In Los Angeles Punk Rock Communities, 1976-1981, Lawson Hammock

Electronic Theses and Dissertations

The chief argument of this work rests on the idea that culture-blindness—especially White ethnic-cultural blindness—contributed as much as issues of race to the heavily documented social rift between predominantly Chicanx, Eastside punk and the mostly-White, Westside punk rock communities of Los Angeles, 1976-1981. To date, historical blame for the divide has centered on racism, including racist intent. The second area of analysis directly relates to the first in that it demonstrates the inextricable link between cultural and spatial identity formation and assignment among the various scenes. This aspect of the study evaluates the complaints of some Eastside acts who have …

Investigating The Role Of Maternal Adiposity On Human Breast Milk And Preterm Infant Stool Short Chain Fatty Acid And Microbiome Profiles, Kristy L. Thomas

Electronic Theses and Dissertations

Preterm birth is the number one cause of death in neonates, accounting for 35% of neonatal mortality. The preterm birth rate in the U.S. in 2021 was 10.5%, disproportionally affected by race and ethnicity. Obese women have an increased risk of preterm pregnancy, and if delivered before 37 weeks of gestation, the offspring have higher rates of complications that extend from the neonatal period into life-long metabolic and immune adverse outcomes. In the early months after delivery, preterm infants have higher rates of adverse health outcomes than term infants, including infections, extrauterine growth restrictions, respiratory, metabolic, and neurological complications, necrotizing …

Improving Implant Training For Physicians And Their Teams In Under-Represented Regions, Jeilan Mohamed, Mohamed Varwani, Abdul Raqib, Emin Evren Ozcan

Internal Medicine, East Africa

The burden of cardiovascular disease is increasing globally, with low- and middle-income countries (LMICs) absorbing most of the burden while lacking the necessary healthcare infrastructure to combat the increase. In particular, the disparity in pacemaker implants between high-income countries and LMICs is glaring, partially spurned by reduced numbers of physicians and supporting staff who are trained in pacemaker implant technique. Herein, we will discuss current pacemaker implant training models, outline training frameworks that can be applied to underserved regions, and review adjunctive training techniques that can help supplement traditional training models in LMICs.

Examining Factors Among People With Opioid Use Disorder And Comorbid Mental Health Disorders, Tori Denae Livingston

Theses and Dissertations

Opioid use disorder (OUD) affects over two million Americans, and over 42,000 Americans perished of opioid overdoses in 2016 (Volkow et al., 2019). During the initial years of the opioid crisis, overdose deaths were primarily attributed to prescription analgesics, heroin, and synthetic opioids. However, it was illicit prescription opioid painkiller use that ranked highest in terms of fatalities (Volkow et al., 2019). The increasing prevalence of opioid use among individuals with mental health disorders is in stark contrast to the ongoing opioid crisis (Prince, 2019). Additionally, there is evidence that individuals undergoing substance use treatment and concurrently suffering from a …

Impact Of Using Gagne’S Nine Events Of Instruction On Student’S Academic Achievement And Satisfaction In An Online English Course For French Speakers, Yara Olive Paterne Loua

Graduate Theses and Dissertations (2019 - present)

This dissertation explored the effect of Gagne's nine events of instruction on student academic achievement and satisfaction during an online English class for French speakers. A group of 30 Facebook users from French-speaking countries in North and Sub-Saharan Africa participated in the research. They were divided randomly into two groups: one receiving traditional instruction through an asynchronous online lecture with PowerPoint presentation, and the other using instruction utilizing Gagne's nine events of instruction integrated with an LMS designed for this purpose. This mixed methods study explored several hypotheses related to academic achievement and satisfaction in the two groups. While the …

Unlocking The Mysteries Of Opportunism: Neuroendocrine Insights From An Aseasonal Breeder (Taeniopygia Guttata), Jessica A. Moodie

Graduate Theses and Dissertations (2019 - present)

The regulation of reproductive physiology in animals is mediated by the Hypothalamus-Pituitary-Gonad (HPG) axis. In seasonal breeders, a conserved reciprocal switching of deiodinase enzymes alters thyroid hormone signaling, which controls HPG activity. This study tested the hypothesis that neural regulation of the HPG axis as described in seasonal systems is conserved and repurposed to respond to other cues in aseasonal species. Using water deprivation and nest restriction in the opportunistic Zebra Finch, we were able to create a breeding group and non-breeding group, confirmed by egg laying and changes in ovarian anatomy. Breeding females had clear follicular hierarchy, increased ovary …

Interactions Between Sediment Mechanical Structure And Infaunal Community Structure Following Physical Disturbance, William Cyrus Roger Clemo

Graduate Theses and Dissertations (2019 - present)

Shallow, river-influenced coastal sediments are important for global carbon storage and nutrient cycling and provide a habitat for diverse communities of invertebrates (infauna). Elevated bed shear stress from extreme storms can resuspend, transport, and deposit sediments, disrupting the cohesive structure of muds, and sorting and depositing sand eroded from beaches. These physical disruptions can also resuspend or smother infauna, decreasing abundances and changing community structure. Infaunal activities such as burrowing, tube construction, and feeding can impact sediment structure and stability. However, little is known about how physical disturbance impacts short and long-term sediment habitat suitability and whether disturbance-tolerant infauna influence …

Gravel Conveyance System: An Evaluation On E. Coli Removal Capabilities, Madison Grace

Graduate Theses and Dissertations (2019 - present)

In many rural, low-income communities such as the Black Belt of Alabama, there is a lack of wastewater infrastructure and solutions leaving homeowners non-compliant to state and federal law and with potential health risks on their property. New regulations have allowed for onsite, surface discharge for single family homes that are not connected to a centralized sewer or large flow development. These new regulations also contain strict disinfection criteria for the treated wastewater that will be discharged. A low-cost and low-maintenance treatment system that provides adequate disinfection is necessary to allow homeowners to take advantage of the new opportunity for …

Who Owns Children’S Dna?, Nila Bala

Michigan Law Review

In recent years, DNA has become increasingly easy to collect, test, and sequence, making it far more accessible to law enforcement. While legal scholars have examined this phenomenon generally, this Article examines the control and use of children’s DNA, asking who ultimately owns children’s DNA. I explore two common ways parents—currently considered “owners” of children’s DNA— might turn over children’s DNA to law enforcement: (1) “consensual” searches and (2) direct-to-consumer testing. My fundamental thesis is that parental consent is an insufficient safeguard to protect a child’s DNA from law enforcement. At present, the law leaves parents in complete control of …

Biological Age Mediates The Effects Of Perceived Neighborhood Problems On Heart Failure Risk Among Black Persons, Ganga Bey, James Pike, Priya Palta, Anthony Zannas, Qian Xiao, Shelly-Ann Love, Gerardo Heiss

Faculty, Staff and Student Publications

OBJECTIVE: We assessed whether biological age, measured by the epigenetic clock GrimAge, mediates the association of objective and subjective neighborhood disadvantage with incident HF among Black persons.

METHODS: Participants were 1448 self-reported Black adults (mean age (standard deviation, SD) = 64.3 (5.5)) dually enrolled in two community-based cohorts in Jackson, Mississippi, the ARIC and JHS cohorts, who were free of HF as of January 1, 2000. Incident HF events leading to hospitalization through December 31, 2017, were classified using ICD-9 discharge codes of HF. Multilevel age- and sex-adjusted Cox causal mediation models were used to examine whether biological age (at …

Validity And Test-Retest Reliability Of A Digital Dynamic Visual Acuity Test Of Vestibular Function, Lydia F. Grunstra, Courtney D. Hall, Kara D. Stressman

Undergraduate Honors Theses

The vestibular system senses head motion and facilitates gaze stabilization, allowing for clear vision during movement. The vestibulo-ocular reflex (VOR) causes the eyes to move opposite head motion, thus maintaining focus on a target. Consequently, uncompensated loss of vestibular function leads to reduced VOR function resulting in dizziness, nausea, and visual disturbance. Different testing methods have been developed to measure VOR loss. These tests generally require bulky, expensive equipment, and must be performed by a trained examiner. A newly developed digital form of the dynamic visual acuity (DVA) test requires less equipment, is cost-effective, and may be performed at home …

The Disney College Experience: A Full Recollection Of Moments And Memories Of The Disney College Program Internship, Lauren Jumonville

Undergraduate Honors Theses

I decided to do the Disney College Program as my honors thesis because Disney is something I am very passionate about. I worked for the Disney Company before and knew that I wanted to continue my experience with them. I went into the program hoping to discover what the college program could do to prepare me (or any prospective programmer) for the profession and for a life in performance. In January of 2023, I made my way to Orlando, Florida, to start my next journey with the Walt Disney World Company. I went through four different orientation processes, as well …

Navigating Through Narratives: The Development Of Opening Cinematics, Jacob Q. Stewart

Undergraduate Honors Theses

This project demonstrates opening cinematic design from conceptualization to final composition. Using Unreal Engine 5, I created an opening cutscene using Unreal’s sequencer editor to film and edit my shots. This document presents the steps I took to create my sequence from the writing process to the final layout. Starting as a written story, I worked my way to the final project by creating a mock scene and storyboarding. After this, I built my scene using assets from the Unreal marketplace and lit my scene with HDRI and dynamic lighting. I encountered many new programs such as Cascade and Mixamo …

Falling Down The Rabbit Hole: World Building In Ya Literature, Claire Webb

Undergraduate Honors Theses

World building is a key component to many young adult novels, but what is world building and what are some different styles and techniques that authors use when constructing fictional universes? In this thesis, Falling Down the Rabbit Hole: World Building Techniques in YA Literature, I will examine Alice’s Adventures in Wonderland by Lewis Carroll (1865), The Princess Bride by William Goldman (1973), and my own unpublished novel, The Sun Kingdom, to compare different techniques and styles of world building. These works will be explored through the aspect of world building, focusing specifically on the importance of the geography, language, …

Angiotensin Ii Type 2 Receptor Signalling As A Pain Target: Bench, Bedside And Back-Translation, Andrew J Shepherd, Andrew Sc Rice, Maree T Smith

Faculty, Staff and Student Publications

Translating promising preclinical pain relief data for novel molecules from drug discovery to positive clinical trial outcomes is challenging. The angiotensin II type 2 (AT2) receptor is a clinically-validated target based upon positive proof-of-concept clinical trial data in patients with post-herpetic neuralgia. This trial was conducted because AT2 receptor antagonists evoked pain relief in rodent models of neuropathic pain. EMA401 was selected as the drug candidate based upon its suitable preclinical toxicity and safety profile and good pharmacokinetics. Herein, we provide an overview of the discovery, preclinical and clinical development of EMA401, for the alleviation of peripheral neuropathic pain.