Digital Commons Network^™

The Impact Of Bowl Feeding On Infant Muscle Activity And Kinematics - An Executive Summary, Kendall Steer

Williams Honors College, Honors Research Projects

Addressing difficulties with swallowing is a small, yet critical portion of a speech-language pathologist’s role. Infants often experience challenges associated with swallowing safely, yet the ability of SLPs to prescribe effective interventions is limited by the lack of knowledge on how anatomy and physiology interact to drive these challenges. The goal of my Honors Research Project is to address this lack of knowledge by determining how the infant pig tongue moves during feeding from a bottle versus drinking from a bowl, as well as how the muscles controlling the tongue differ in these behaviors. I used infant pigs for this …

Bite Force And Stress Content Of Varying Tooth Morphology And Jaw Alignment, Emily Newenhisen

Williams Honors College, Honors Research Projects

Biting is one of the primary physical actions against a food substrate involved in the process of mastication and consumption. Different shapes of solidified tissue (e.g., teeth, mandibles) are developed based on dietary preferences of the organism to improve mechanical function. Models of various geometric shapes were used to loosely replicate several common biological tooth structures. As there is little research conducted on tooth penetration force in relation to tooth shape, collection of such data was the main focus of the research. Molariform teeth found in herbivores were represented by the ball model, carnivorous needle-like teeth by cone model, cutting …

Environmental Destruction And Human Rights Abuses In The Democratic Republic Of The Congo: Examining The Epicenter Of The Cobalt Mining Industry From An International Criminal Law Perspective, Joe Udell

Minnesota Journal of International Law, Vols. 28:2 onward (2019-present)

No abstract provided.

Urgenda, Milieudefensie, And The Impact Of Climate Change Litigation On Global Trade Policy, Maria Saracino-Lowe

Minnesota Journal of International Law, Vols. 28:2 onward (2019-present)

No abstract provided.

Trade-Based Regulation Of Space Resources, Jamie G. Mcwilliam

Minnesota Journal of International Law, Vols. 28:2 onward (2019-present)

No abstract provided.

Detection Of Various Dental Conditions On Dental Panoramic Radiography Using Faster R-Cnn, Shih Lun Chen, Tsung Yi Chen, Yi Cheng Mao, Szu Yin Lin, Ya Yun Huang, Chiung An Chen, Yuan Jin Lin, Mian Heng Chuang, Patricia Angela R. Abu

Department of Information Systems & Computer Science Faculty Publications

The dental panoramic radiograph (DPR) is a pivotal diagnostic tool in dentistry. However, despite the growing prevalence of artificial intelligence (AI) across various medical domains, manual methods remain the prevailing means of interpreting DPR images. This study aims to introduce an advanced identification system for detecting seven dental conditions in DPR images by utilizing Faster R-CNN. The primary objectives are to enhance dentists' efficiency and evaluate the performance of various CNN models as foundational training networks. This study contributes significantly to the field in several notable ways. Firstly, including a Butterworth filter in the training process yielded an approximately 7% …

2023 Research Fronts: 128 Research Fronts Revealed

Double Helix Methodology

November 28, the Institutes of Science and Development,Chinese Academy of Sciences (CASISD), the National Science Library of Chinese Academy of Sciences, and Clarivate released two reports, namely “2023 Research Fronts” and “Research Front 2023: Active Fields, Leading Countries/Regions”, at a joint forum in Beijing.

2023 Scotus Report: Americans Reacted With Disgust And Sadness Toward The Scotus' Recent Rulings, Yi Luo, Bond Benton, Jin-A Choi, Keith Strudler, Keith Green

College of Communication and Media Scholarship and Creative Works

On June 29, SCOTUS struck down affirmative action, ruling the race-conscious admissions programs at colleges and universities unconstitutional. Then, on June 30, SCOTUS handed down another landmark ruling which outlawed student loan forgiveness and terminated President Biden’s plan to provide student loan reliefs for tens of millions of Americans. This high court’s decision on student loans will likely affect one in eight Americans, leaving student loan borrowers feeling frustrated, defeated, and angry. As online media have increasingly played a central role in facilitating civic engagement and shaping individuals’ decisions on contested issues, this study thus examines how social media users …

Human Interaction With The Divine, The Sacred, And The Deceased: Topics That Warrant Increased Attention By Psychologists, Thomas G. Plante, Gary E. Schwartz, Julie J. Exline, Crystal L. Park, Raymond F. Paloutzian, Rüdiger J. Seitz, Hans-Ferdinand Angel

Psychology

Humans have likely been attempting to communicate with entities believed to exist, such as the divine, sacred beings, and deceased people, since the dawn of time. Across cultures and countries, many believe that interaction with the immaterial world is not only possible but a frequent experience. Most religious traditions across the globe focus many rituals and activities around prayer to an entity deemed divine or sacred. Additionally, many people–religious, agnostic, and atheists alike–report communication with their departed loved ones. During highly stressful times associated with natural disasters, war, pandemics, and other threats to human life, the frequency and intensity of …

Globe Srs Poster Gallery, Globe U.S. Coordination Office

Resources

No abstract provided.

Indian Policing: Agents Of Assimilation, Kekek Jason Stark

Case Western Reserve Law Review

No abstract provided.

The Under-Policing Of Crimes Against Black Women, Lisa Avalos

Case Western Reserve Law Review

No abstract provided.

Shortened Limitation Periods In Employment Contracts: A “Reasonable” Suggestion, Andrew Thompson

Case Western Reserve Law Review

No abstract provided.

Assessing Lanes For Change: The Role Of Occupational Therapy In Water Safety And Swimming Programs, Avery Adams Fornaciari

OTD DEx Reports - College of Pharmacy and Health Sciences

"Drowning is the number one cause of death for children ages 1 to 4 years, and the second leading cause of unintentional death in children ages 5 to 14 years old in the United States (Centers for Disease Control and Prevention, 2022). Globally, drowning remains a public health crisis, as it is the third most common cause of intentional death (World Health Organization, 2021). On the topic of water-related injuries and fatalities, the literature has displayed the influence of socioeconomic disadvantage and geographic location as being associated with an increased drowning risk (Willcox-Pidgeon et al., 2021). In addition, a cyclic …

Implementation Of Pediatric Services At A Pro Bono University Ot Center, Deanna Padilla

OTD DEx Reports - College of Pharmacy and Health Sciences

"With a focus on bringing equity, accessibility, and rehabilitation to all people, and achieving wellness in the Greater Springfield area, a student-run Occupational Therapy (OT) center should serve all populations. The completion of this Doctoral Experiential (DEx) capstone project allowed the BEAR PAW OT Center (BPC) at Western New England University (WNE) to officially provide services to all populations within the community. The process of implementing pediatric services at the BPC included redesigning and organizing the designated pediatric space, which meant designing the space to be appealing for the pediatric population, ordering supplies and equipment, and ensuring the space is …

Moon Trees Globe Activities And Resources, Globe U.S. Coordination Office

Teacher Resources

No abstract provided.

Writing For A “High Purpose”: Examining Charles Chesnutt’S Antiracist Manipulation Of Genre And Language In The Conjure Woman, Sheniah Lanier

Masters Essays

No abstract provided.

Expanding Our Grasp Of Two-Component Signaling In Clostridioides Difficile, Orlando Berumen Alvarez, Erin B. Purcell

Chemistry & Biochemistry Faculty Publications

The intestinal pathogen Clostridioides difficile encodes roughly 50 TCS, but very few have been characterized in terms of their activating signals or their regulatory roles. A. G. Pannullo, B. R. Zbylicki, and C. D. Ellermeier (J Bacteriol 205:e00164-23, 2023, https://doi.org/10.1128/jb.00164-23) have identified both for the novel C. difficile TCD DraRS. DraRS responds to antibiotics that target lipid-II molecules in the bacterial cell envelope, and regulates the production of a novel glycolipid necessary for bacitracin and daptomycin resistance in C. difficile.

A Study Of The Structure-Activity Relationships Of Carcinogenic Protein- And Dna-Binding Chemicals, Alicia M. Crisalli

Open Access Dissertations

Chapter 1

Chemical contaminants in our environment may interact with macromolecules such as proteins and DNA in our bodies and have the potential to disrupt normal biological processes, leading to diseases such as cancer and metabolic conditions. Elucidation of these mechanisms, particularly the relationship between their structure and subsequent biological outcomes, is paramount to mitigating the harm associated with human exposure to such contaminants. It is also an important tool in the drug design/discovery process. This introductory chapter shall serve as background knowledge for readers unversed in the field, outlining several families of persistent chemical contaminants known to cause cancer …

A Characterization Of Key Residues In Class I Viral Fusion Proteins Important For Fusogenic Activity, Hadley E. Neal

Theses and Dissertations--Molecular and Cellular Biochemistry

Viral fusion proteins are critical for viral entry and subsequent infection. Class I fusion proteins are characterized by synthesis as an inactive precursor requiring cleavage by a host cell protease to become fusion competent. Though vaccine and antiviral therapeutic developments often target the fusion protein, questions surrounding cleavage dynamics and protein stability remain. The work presented in this dissertation investigates specific regions of three class I viral fusion proteins in an effort to identify key residues involved in proteolytic processing and membrane fusion.

The trimeric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein (S) mediates receptor binding, facilitates fusion …

Characterization Of The Function And Regulation Of The Hmpv Phosphoprotein, Rachel Thompson

Theses and Dissertations--Molecular and Cellular Biochemistry

Human metapneumovirus (HMPV) is a non-segmented, negative strand RNA virus (NNSV) that frequently causes respiratory tract infections in infants, the elderly, and the immunocompromised. Despite the initial identification of HMPV in 2001, there are currently no FDA approved antivirals or vaccines available. Therefore, understanding the mechanism of HMPV replication is critical for the identification of novel therapeutic targets. A key feature in the replication cycle of HMPV and other NNSVs is the formation of membrane-less, liquid-like replication and transcription centers in the cytosol termed inclusion bodies (IBs). Recent work on NNSV IBs suggests they display characteristics of biomolecular condensates formed …

Advancements In Glycogen Detection And Spatial Profiling Reveals A New Therapeutic Path For Ewing Sarcoma: A Non-Traditional Glycogen Storage Disease, Lyndsay E. A. Young

Theses and Dissertations--Molecular and Cellular Biochemistry

Glycogen is the primary glucose storage carbohydrate in mammals, and it is synthesized in most tissues. As glycogen architecture modulates its role in metabolism, it is essential to accurately evaluate and quantify glycogen, glycogen phosphate, and chain length of glucose monomers. Simultaneous quantitation of glycogen architecture is challenging. This work describes a highly-sensitive method for the detection of both glycogen-derived glucose and glucose-phosphate esters utilizing gas-chromatography coupled mass spectrometry (GCMS). We then integrated this glycogen quantitation workflow into a routinely utilized metabolomics-based assay. The work presented describes a workflow for the normalization of polar metabolites utilizing amino acids derived from …

Investigating The Roles Of Platelet Bioenergetics In Hemostasis And Thrombosis, Kanakanagavalli Shravani Prakhya

Theses and Dissertations--Molecular and Cellular Biochemistry

Platelets use a series of energy-dependent processes to mediate hemostasis, yet it is unclear which metabolic fuels/pathways are critical for platelet function. Platelets are metabolically flexible, switching between glycolysis and oxidative phosphorylation (OxPhos) depending on oxygen tension and substrate availability. The deletion of GLUT1 and GLUT3 together revealed an essential role in platelet function and hemostasis. To study platelet bioenergetics, we used clot contraction. We created a sensitive and inexpensive method to simultaneously assess clot contraction kinetics to directly compare and define the effects of different treatments or genetic manipulations on platelet function.

Since the pharmacological inhibitors cannot be used …

Activity Levels Of Different Cell Types In An Epileptogenic Model Of Cortical Microgyria: A Cfos Investigation, Peter F. Lamothe

Theses and Dissertations

A large percentage of individuals with intractable epilepsies have an accompanying cortical malformation, the underlying cellular mechanisms of which are not fully understood. In an animal model for one such malformation, polymicrogyria, epileptogenesis occurs most easily in a region of tissue just adjacent to the microgyria termed the paramicrogyral region (PMR). Previous studies implicate somatostatin containing interneurons (SOM) as a potential contributor to this pathology, and show increased excitation of SOM in the PMR. We hypothesis that SOM are more active in the PMR when compared to SOM within the homologous region of the control cortex. In addition to this …

Formation Of Vasculogenic Mimicry: Role Of Melanoma Differentiation Associated Gene-9 In Human Melanoma, Jinkal Shah

Theses and Dissertations

Malignant melanoma (MM) is the most aggressive skin cancer and the most frequent skin disorder in Caucasians. MM is associated with aggressive and progressive disease states, leading to major cancer-related morbidity and mortality. Recent investigations identify an alternative pathway -vasculogenic mimicry (VM), which is considered a cancer hallmark that can independently facilitate tumor neovascularization by the formation of fluid-conducting and vascular endothelial cells. MM cells undergoing VM can dedifferentiate into numerous cellular phenotypes and acquire endothelial-like features, resulting in the formation of the de novo matrix-rich vascular-like networks, such as plasma and red blood cells. The co-generation of endothelial cells, …

Stuffed Animals For Coping And Communication In The Hospital: A Child Life Perspective, Becca Scobee

EWU Masters Thesis Collection

No abstract provided.

Engineering Technology Program, Technology

Program Revisions/Additions

No abstract provided.

Clinical Laboratory Science Major, Biological Sciences

Program Revisions/Additions

No abstract provided.

Multi-Omic And Single-Cell Characterization Of A 3d Skin-Like Tissue Model Of Systemic Sclerosis With A Focus On Epigenetics, Tamar R. Abel

Dartmouth College Ph.D Dissertations

Systemic sclerosis (SSc) is a rare fibrotic autoimmune disease with high mortality and limited FDA approved therapies. Clinical concordance among twins is low; however, a modest familial heritability implicates complex interactions between polygenic risk alleles and the environment as causal – interactions that are mediated by epigenetics. Although mechanisms of tissue fibrosis have been successfully identified and targeted in established in vitro models for SSc, these molecules have ultimately failed in clinical trials. This likely reflects the lack of a reliable in vitro model that faithfully recapitulates the disease.

I utilized a 3D skin-like tissue model to study SSc skin …

Commencement Program, 2023, Cuny John Jay College Of Criminal Justice

Reports and Publications from John Jay College

Commencement Programs are handed out at each graduation. They include information on honorary degrees, awards and prizes and candidates for degree. However, they cannot be considered an official record of conferring of degrees.