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Surveillance And Monitoring Of Amphibian Pathogens And Evaluating The Impacts Of An Associated Course-Based Undergraduate Research Experience (Cure), Jennifer Perez

EWU Masters Thesis Collection

Amphibians are a highly diverse class of vertebrates and crucial for natural ecosystems, inhabiting both aquatic and terrestrial environments at different life stages. However, amphibians are facing devastating declines largely due to the disease chytridiomycosis, caused by the fungal pathogens Batrachochytrium dendrobatidis (Bd) and Batrachochytrium salamandrivorans (Bsal). This disease can lead to population declines, biodiversity loss, and species extinction. However, resources to study and mitigate this disease are limited and an opportunity to assist in these efforts has been created in the form of a course-based undergraduate research experience (CURE). Chapter 1 of my thesis used Roger's Diffusion of Innovations …

Exploring The Metabolic Capabilities And Biotransformation Potential Of Environmental Lactococcus Strains, Desirée Román Naranjo

Theses

The aim of this thesis is to characterize environmental Lactococcus strains to identify different and diverse metabolic capabilities that could be applied to microbial biotransformation, defined as the conversion of a cheap/waste substrate into a value-added product. Due to the increased amounts of food processing waste generated worldwide and the impact of climate change, new sustainable approaches are necessary to contribute to waste valorization and the circular bioeconomy. We ask to what extent and in what ways environment isolated Lactococcus strains could contribute to food biotransformation by metabolizing a different range of substrates. We do so to further understand and …

Investigating Optimal Lipid:Protein Profiles For Infant Milk Formula, Valentina Ivanova

Theses

From the early twentieth century onward, much research has focused on improving infant milk formula (IMF). During the development of IMF, breast milk is commonly considered as the reference and IMF manufacturers are thriving to mimic the composition and/or to match the functionality of breast milk as closely as possible. A variety of bioactive ingredients, found in human breast milk, have been isolated and investigated for their potential functionality and utilised in the production of IMF. This study evaluated the current knowledge on compositional differences between human breast milk and IMF, and recent advances and developments in IMF production. Following …

Isolation And Characterisation Of Soil-Derived Bacteria With Antimicrobial Activity Against Antibiotic Resistant Pathogens, Ellen Twomey

Theses

Bacteriocins are a diverse range of ribosomally synthesized bioactive peptides, recognised predominantly for their potent antimicrobial activity against other strains closely related to the producer. The focus of this thesis was to explore this activity and examine the potential of bacteriocins to inhibit the growth of clinically relevant pathogens. Although evidence exists in the literature to suggest that bacteriocins could be applied in a similar fashion to conventional antibiotics, to date they are only utilised as preservative in food to prevent the growth of foodborne illness causing organisms. Isolating and screening bacterial strains in order to identify bacteriocin producers has …

The Use Of Membrane Filtration To Increase Native Whey Protein In Infant Formula, And Effects On Bioaccessibility And Bioactivity, Yihong Chen

Theses

Breastfeeding is recognised as the gold standard for feeding newborns and infants. However, infants who cannot be breast-fed or for whom breast milk is not available, can be fed with bovine infant milk formula (IMF) as a substitute. Researchers and producers of IMF strive to continually improve or “humanise” the composition and functionality of IMF. During production of IMF it must undergo several heat treatment steps, e.g. heat-sterilisation or spray-drying, in order to provide a safe product to the infant. These heat treatments denature the globular whey proteins in IMF. In contrast, breast milk is by its nature unheated, so …

Intra-Marrow Penetrations And Root Coverage Outcomes: A Systematic Review, Vrisiis Kofina, Ving Wang, Alissa V. Fial, Dimitris N. Tatakis

School of Dentistry Faculty Research and Publications

Background

Intra-marrow penetrations (IMPs) have been performed during guided tissue regeneration (GTR) procedures with reported clinical benefits. The aim of this systematic review was to investigate the use and effect of IMPs during root coverage procedures.

Method

A broad search for human and animal studies was performed on PubMed, Cochrane Database of Systematic Reviews and Cochrane Central Registry of Controlled Trials and Web of Science, following a registered review protocol (PROSPERO). All prospective study designs, case series and case reports on gingival recession treatment (follow-up ≥ 6 months) that employed IMPs were included. Root coverage, complete root coverage prevalence, and …

Immunohistochemical Markers Of Temporomandibular Disorders: A Review Of The Literature, Luis Eduardo Almeida, Andrea Doetzer, Matthew L. Beck

School of Dentistry Faculty Research and Publications

Temporomandibular disorders (TMD) are a group of internal derangements encompassing dysfunction, displacement, degeneration of the temporomandibular joints and surroundings muscles of mastication, often accompanied by pain. Relationships between TMD and various chemical biomarkers have been examined throughout the years. This paper aims to gather evidence from the literature regarding other biomarkers and presenting them as one systematic review to investigate the potential links between TMD and different biochemical activity. To identify relevant papers, a comprehensive literature search was carried out in MEDLINE/PubMED, EMBASE, Web of Science and a manual search was performed in the International Journal of Oral and Maxillofacial …

Measuring Follow-On Innovation, Janet Freilich, Sepehr Shahshahani

Faculty Scholarship

How patents affect follow-on innovation is a key question for the patent system. We disaggregate follow-on innovation into activities that infringe patents and others that do not infringe but can be indirectly affected by patents. Replicating an important study using our disaggregated measure, we find that 87 percent of followon innovation is not patent infringement. Supplementing the study’s empirical strategy with data on patent expiration dates, we find that gene patents which are not close to expiration cause an increase in noninfringing follow-on research, but the effect disappears for patents close to expiration. Our nuanced measure helps better identify the …

Composition, Nutritional And Physicochemical Properties Of Milk Fat Globule Membrane Enriched Ingredients For Use In Infant Nutrition Products, Pierre Ponchon

Theses

The aim of this thesis was to investigate the nutritional, techno-functional and physicochemical properties of milk fat globule membrane (MFGM) enriched whey protein concentrate (WPC) ingredients. This research focused on the physicochemical, nutritional, techno-functional, and microstructural properties of MFGM-enriched whey protein concentrate (WPC) powder ingredients, which included 3 MFGM-enriched WPC ingredients and a WPC ingredient co-enriched with α-lactalbumin and MFGM. These were compared to parallel stream (WPC 80 and whey protein isolate (WPI)) and upstream, whole milk powder (WMP) bovine derived ingredients of varying macromolecular composition, including MFGM-enrichment. The macromolecular compositions of the MFGM-enriched WPC ingredients included fat contents ranging …

Extranormal Sorcery In Toni Morrison's Song Of Solomon, Harleyquinn Wahl

EWU Masters Thesis Collection

No abstract provided.

Fairy Shrimp (Anostraca) In The Vernal Pools Of Eastern Washington, Megan Garvey

EWU Masters Thesis Collection

Vernal pools are ephemeral wetlands that retain water annually from winter and spring precipitation and snowmelt but are dry the rest of the year. Though important habitats and sources of freshwater biodiversity, they are little accounted for in wetland conservation and restoration practices. Like much of the world’s wetlands, they have seen a significant decline from anthropogenic impacts and conversion for alternative land use. Pools are also at significant risk due to the impacts of climate change and invasive species. These small temporary water bodies perform vital ecosystem services and are host to rare and endemic species. Anostraca, or fairy …

Microrna-1 Attenuates The Growth And Metastasis Of Small Cell Lung Cancer Through Cxcr4/Foxm1/Rrm2 Axis, Parvez Khan, Jawed A. Siddiqui, Prakash Kshirsagar Dr., Ramakanth Chirravuri Venkata, Shailendra K. Maurya, Tamara Mirzapoiazova, Naveenkumar Perumal, Sanjib Chaudhary, Ranjana K. Kanchan, Mahek Fatima, Md Arafat Khan, Asad Ur Rehman, Imayavaramban Lakshmanan, Sidharth Mahapatra, Geoffrey A. Talmon, Prakash Kulkarni, Apar Kishor Ganti, Maneesh Jain, Ravi Salgia, Surinder K. Batra, Mohd W. Nasser

Journal Articles: Biochemistry & Molecular Biology

BACKGROUND: Small cell lung cancer (SCLC) is an aggressive lung cancer subtype that is associated with high recurrence and poor prognosis. Due to lack of potential drug targets, SCLC patients have few therapeutic options. MicroRNAs (miRNAs) provide an interesting repertoire of therapeutic molecules; however, the identification of miRNAs regulating SCLC growth and metastasis and their precise regulatory mechanisms are not well understood.

METHODS: To identify novel miRNAs regulating SCLC, we performed miRNA-sequencing from donor/patient serum samples and analyzed the bulk RNA-sequencing data from the tumors of SCLC patients. Further, we developed a nanotechnology-based, highly sensitive method to detect microRNA-1 (miR-1, …

Specific Targeting And Labeling Of Colonic Polyps In Cpc-Apc Mice With Mucin 5ac Fluorescent Antibodies: A Model For Detection Of Early Colon Cancer, Michael A. Turner, Kristin E. Cox, Shanglei Liu, Nicholas Neel, Siamak Amirfakhri, Hiroto Nishino, Mojgan Hosseini, Joshua A. Alcantara, Amer Ali Abd El-Hafeez, Thinzar M. Lwin, Kavita Mallya, Joseph R. Pisegna, Satish K. Singh, Pradipta Ghosh, Robert M. Hoffman, Surinder K. Batra, Michael Bouvet

Journal Articles: Biochemistry & Molecular Biology

Poor visualization of polyps can limit colorectal cancer screening. Fluorescent antibodies to mucin5AC (MUC5AC), a glycoprotein upregulated in adenomas and colorectal cancer, could improve screening colonoscopy polyp detection rate. Adenomatous polyposis coli flox mice with a Cdx2-Cre transgene (CPC-APC) develop colonic polyps that contain both dysplastic and malignant tissue. Mice received MUC5AC-IR800 or IRdye800 as a control IV and were sacrificed after 48 h for near-infrared imaging of their colons. A polyp-to-background ratio (PBR) was calculated for each polyp by dividing the mean fluorescence intensity of the polyp by the mean fluorescence intensity of the background tissue. The mean 25 …

Gpcrs And Fibroblast Heterogeneity In Fibroblast-Associated Diseases, Nidhi V. Dwivedi, Souvik Datta, Karim El-Kersh, Ruxana Sadikot Md, Mrcp, Apar Kishor Ganti, Surinder K. Batra, Maneesh Jain

Journal Articles: Biochemistry & Molecular Biology

G protein-coupled receptors (GPCRs) are the largest and most diverse class of signaling receptors. GPCRs regulate many functions in the human body and have earned the title of "most targeted receptors". About one-third of the commercially available drugs for various diseases target the GPCRs. Fibroblasts lay the architectural skeleton of the body, and play a key role in supporting the growth, maintenance, and repair of almost all tissues by responding to the cellular cues via diverse and intricate GPCR signaling pathways. This review discusses the dynamic architecture of the GPCRs and their intertwined signaling in pathological conditions such as idiopathic …

Roles Unveiled For Membrane-Associated Mucins At The Ocular Surface Using A Muc4 Knockout Mouse Model, Rafael Martinez-Carrasco, Satyanarayan Rachagani, Surinder K. Batra, Pablo Argüeso, M Elizabeth Fini

Journal Articles: Biochemistry & Molecular Biology

Membrane-associated mucins (MAMs) are proposed to play critical roles at the ocular surface; however, in vivo evidence has been lacking. Here we investigate these roles by phenotyping of a Muc4 KO mouse. Histochemical analysis for expression of the beta-galactosidase transgene replacing Muc4 revealed a spiraling ribbon pattern across the corneal epithelium, consistent with centripetal cell migration from the limbus. Depletion of Muc4 compromised transcellular barrier function, as evidenced by an increase in rose bengal staining. In addition, the corneal surface was less smooth, consistent with disruption of tear film stability. While surface cells presented with well-developed microprojections, an increase in …

Multimodal Game-Based Learning In Post-Secondary Education, Nathan A. Vanos

EWU Masters Thesis Collection

In this age of unprecedented technological proliferation, educators have been given a unique opportunity to enhance classroom engagement. That opportunity is multimodal game-based learning (MGBL): classroom instruction through a combination of games and multiple modalities of information. Using today’s 3D systems and virtual reality tools, this concept can be explored to depths never before possible. The aim of this project was to design and implement an application that could be used to evaluate how MGBL could impact student engagement and learning, specifically at the post-secondary level. The application implemented during this work was a 3D and virtual reality Simulator for …

Malthi In Media: Peopling An Ancient Village In Virtual Space, Rebecca Worsham, Sarah Kam, Annika Lof, Nora Sullivan, Aurora Bagley

Other Student Projects

STRIDE Project "A Digital Archaeology of Malthi, Greece"

/="/">Digital applications have increased the possibilities for the visualization of archaeological material. Here are presented two reconstructions of the Bronze Age settlement Malthi, created using Minecraft and Twine, both readily accessible programs. These recreations draw on data from archaeological work at the site and are intended to depict alternative interpretations of the settlement, allowing for the uncertainty inherent in archaeology. They are likewise intended to invite interaction with the site beyond physically visiting, with the goal of increasing participation in the formation of knowledge about Malthi. The approach advocated here is …

A Comparison Of Chief Complaints, Specific Diagnoses, And Demographics Of Pediatric Urgent Care Visits Before And During The Covid-19 Pandemic: A Retrospective Study, Zaharoula A. Viennas, Julie Martin, Benjamin Klick, Tammy Speerhas, Turaj Vazifedan, Danielle Millspaugh, Jennifer Ferris, Margret Bedle, Lauren Paluch, Theresa Guins

Ellmer School of Nursing Faculty Publications

There was an increased incidence of pediatric patients who presented with injuries caused by falls not related to sports or other recreational activities, as well as for animal bites, during the early pandemic period of April 2020. Education of parents and caregivers of young children is warranted to raise awareness of the even greater potential for falls and animal bites when children are confined at home for longer than typical periods of time, as occurred with the stay-at-home government orders during the initial period of the COVID-19 pandemic.

Enforcing Soft Law In International Investment Arbitration, Vera Korzun

Akron Law Faculty Publications

Drawing examples from international environmental law, sustainable development, and corporate social responsibility, this Article examines the evolving role of international investment arbitration in the enforcement of non-binding soft law rules of international law. In doing so, the Article explains how investment tribunals can, and have been called upon to, interpret and, paradoxically, enforce soft law instruments. The Article calls for reevaluation of the nature of soft law and the role of investor-state dispute settlement in international rulemaking and enforcement. It also argues that for international environmental law and law on sustainable development, where the lack of an enforcement mechanism has …

Notices, Editorial Office

Contemporary Aesthetics (Journal Archive)

No abstract provided.

Editorial: International Myopia Institute White Paper Series 2023, Nina Tahhan, James S. Wolffsohn, Padmaja Sankaridurg, Jost B. Jonas, Mark A. Bullimore, Ian Flitcroft, Lisa A. Ostrin, Christine Wildsoet, Serge Resnikoff

Research Outputs: 2025-Present

No abstract provided.

New Approach Methodologies (Nams) For Safety Testing Of Complex Food Matrices: A Review Of Status, Considerations, And Regulatory Adoption, Maame Ekua Manful, Lubna Ahmed, Catherine Barry-Ryan

Research Outputs: 2025-Present

Background: The conventional toxicological approach which primarily relies on animal testing has undergone several transformations in recent years due to limitations in translational relevance, ethical and reproducibility concerns, high costs, and time-consuming procedures. New Approach Methodologies (NAMs) have emerged as alternative techniques that incorporate in silico, in chemico, and in vitro approaches to provide mechanism-based insights with improved ethics and human-relevant safety data. Scope and approach: The current landscape of NAMs employed for food risk assessments in research and regulatory settings is examined with a focus on their strengths, limitations, validation, standardisation, and regulatory status. Furthermore, the challenges associated with …

Video Anomaly Detection Using Residual Autoencoder: A Lightweight Framework, Mohamed H. Habeb, May A. Salama, Lamiaa A. Elrefaei

Mansoura Engineering Journal

This paper proposes an efficient lightweight deep spatial residual autoencoder (SRAE) model to detect anomalous events in video surveillance systems. A lightweight network is essential in real-time situations where time is critical. Moreover, it could be deployed on low-resource devices like embedded systems or mobile devices. This makes it a very useful option for real-world situations where there may be a shortage of resources. The proposed network is composed of a 3-layer residual encoder-decoder architecture that is adopted to acquire the salient spatial characteristics representative of normal events in videos. Then, the reconstruction loss is used to find abnormalities, where …

Rrh Library Newsletter, Winter 2023, Libraries At Rochester Regional Health

Rochester Regional Health authored publications and proceedings

Newsletter sections include: RRH Archives Join the RRH Libraries; Access ObGyn and Access Emergency Medicine E-Book collections now available; Lexicomp; Have You tried EndNote?; Recently Released Guidelines

Public Law Litigation And Electoral Time, Zachary D. Clopton, Katherine Shaw

Articles

Public law litigation is often politics by other means. Yet scholars and practitioners have failed to appreciate how public law litigation intersects with an important aspect of politics-electoral time. This Essay identifies three temporal dimensions of public law litigation. First, the electoral time of government litigants-measured by the fixed terms of state and federal executive officials-may affect their conduct in litigation, such as when they engage in midnight litigation in the run-up to and aftermath of their election. Second, the electoral time of state courts-measured by the fixed terms of state judges-creates openings for strategic behavior among litigants (both public …

Turkish-German Heritage Speakers’ Predictive Use Of Case: Webcam-Based Vs. In-Lab Eye-Tracking, Onur Özsoy, Büsra Çiçek, Zeynep Özal, Natalia Gagarina, Irina A. Sekerina

Publications and Research

Recently, Özge et al. have argued that Turkish and German monolingual 4-year- old children can interpret case-marking predictively disregarding word order. Heritage speakers (HSs) acquire a heritage language at home and a majority societal language which usually becomes dominant after school enrollment. Our study directly compares two elicitation modes: in-lab and (remote) webcam- based eye-tracking data collection. We test the extent to which in-lab e��ects can be replicated in webcam-based eye-tracking using the exact same design. Previous research indicates that Turkish HSs vary more in the comprehension and production of case-marking compared to monolinguals. Data from 49 participants–22 Turkishmonolinguals and …

2023-2024 Faculty Handbook, Morehead State University. Faculty Senate.

Faculty Senate Records

Morehead State University Faculty Handbook for 2023-2024.

Coming Out While Going Fast: Queer Conviviality In Speedrunning Live Streams, Johanna Brewer

Computer Science: Faculty Publications

Drawing on ethnographic research of LGBTQIA+ live streaming speedrunners, this article demonstrates how by centering queer perspectives, we can catalyze meaningful social changes for all. Though for most people, beating the original Super Mario Bros. in under five minutes would seem unfathomably difficult, LGBTQIA+ speedrunning live streamers regularly accomplish this superhuman feat, while coming out to an audience of thousands at the same time. For queer and trans folks, broadcasting such a transgressive, transformational form of play is defiant demonstration of vulnerability; one that creates a comfortable space for a community to thrive, by cultivating a culture of queer conviviality. …

Image Schema Decompositions Of The Conceptual Dependency Ingest Primitive: A Study Of Paraphrases, Jamie C. Macbeth, Alexis Kilayko, Zoie Zhao, Sophie Song, Winniw X. Zheng

Computer Science: Faculty Publications

One of the hallmarks of the Schank-Minsky Conceptual Dependency Trans-Frames meaning representation system is that it attempts to express complex meanings by building large and complex conceptual structures using a relatively small number of primitives. Recently comparisons of image schemas with Conceptual Dependency primitives revealed ways of possibly reducing the number of primitives while maintaining the expressiveness of the set—an important research goal because it increases the flexibility and richness of the primitive-decomposed structures in a way that better approximates human cognition. Inspired by this prior work, we employ a paraphrase generation system to explore the replacement of the Conceptual …

It's A Code: Amending The Federal Rules Of Evidence To Achieve Uniform Results, Daniel J. Capra, Jessica Berch

Faculty Scholarship

This Article identifies, explores, and attempts to resolve nine conflicts that have arisen in the federal courts regarding the proper interpretation and scope of the Federal Rules of Evidence. For each conflict, we set forth the language of the current rule, its policy goals, and the differing positions taken by the courts. We then analyze the merits of the debate and propose new rule language to resolve the matter.

In this Article, we consider whether theft-based convictions are automatically admissible under Rule 609(a)(2), and how to calculate the passage of ten years for old convictions under Rule 609(b). We chart …