Digital Commons Network^™

From Child To Children: The Experiences Of Economically Marginalized Parents As Their Family Sizes Grow, Yvanna Pogue Vicks

LSU New Orleans Theses and Dissertations

No abstract provided.

A Novel Role Of Tgfbi In Macrophage Polarization And Macrophage-Induced Pancreatic Cancer Growth And Therapeutic Resistance, Jing Zhou, Nan Lyu, Qiongling Wanga, Ming Yang, Eric T. Kimchi, Kun Chenge, Trupti Joshi, Adama R. Tukulif, Kevin F. Staveley-O’Carroll, Guangfu Li

Biomedical Sciences

Tumor-associated macrophages (TAMs), as a major and essential component of tumor microenvironment (TME), play a critical role in orchestrating pancreatic cancer (PaC) tumorigenesis from initiation to angiogenesis, growth, and systemic dissemination, as well as immunosuppression and resistance to chemotherapy and immunotherapy; however, the critical intrinsic factors responsible for TAMs reprograming and function remain to be identified. By performing single-cell RNA sequencing, transforming growth factor-beta-induced protein (TGFBI) was identified as TAM-producing factor in murine PaC tumors. TAMs express TGFBI in human PaC and TGFBI expression is positively related with human PaC growth. By inducing TGFBI loss-of-function in macrophage (MΦs) in vitro …

Oncolytic Tanapoxvirus Recombinants Expressing Mil-2, Flagellin-C, And Mccl2 Regress Human Cancer Xenografts In Immune Deficient Nude Mice And Immune Cell Reconstituted Balb/C Nude Mice., Michael Leonard Monaco

Dissertations

Tanapoxvirus (TPV) is a double stranded DNA virus from the genus Yatapoxvirus which has been engineered for the purpose of potentially treating a number of human cancers. Previous studies have shown TPV recombinants are capable of inducing tumor inhibition and even regression in athymic nude mice bearing human cancer xenografts of colorectal, melanoma and triple negative breast cancer (TNBC). However, TPV is host-restricted to humans and monkeys, including cancerous cells, which has provided a unique obstacle in its development as an oncolytic virus (OV). Namely, standard syngeneic mouse models cannot be used as test systems to evaluate TPV’s efficacy against …

Of Corpses And Persons: Examining A Cadaver As An Object And Subject Of Rights, Arseny Shevelev, Georgy Shevelev

Louisiana Law Review

No abstract provided.

Let’S Give Digital: How Louisiana’S Laws Governing Inter Vivos Donations Are Unequipped To Handle The Growing Popularity Of Digital Assets, Zack Crawford

Louisiana Law Review

No abstract provided.

Carbon Sequestration: A Pipedream Or The Solution To Global Warming?, Caroline Mccullars

Louisiana Law Review

No abstract provided.

Putting Dance In Triple Threat: Confidence And Knowledge Of Dancing In Middle School Actors, Miranda Taylor

Master's Theses

The purpose of this study is to alleviate feelings of inadequacy in middle school musical theater actors through gained dance knowledge and confidence. The researcher evaluated middle school actors throughout the rehearsal process of a musical. The goal was to answer these three essential questions: Q1 Does feeling confident on stage as an actor/singer correlate with being a confident dancer? Q2 How can dance and choreography be used to increase confidence? Q3 How does previous dance experience effect confidence during a musical? Pre and post questionnaires were given to students who were cast in the show. The data suggested that …

Investigating The Therapeutic Potential Of Cannabigerol (Cbg) In Female Nonalcoholic Steatohepatitis (Nash) Mouse Model, Raznin A. Joly

Master's Theses

Nonalcoholic Steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease (NAFLD) characterized by inflammation, fibrosis, steatosis, and oxidative stress, in addition to excessive fat accumulation in the liver. Cannabigerol (CBG), a precursor molecule of Cannabidiol (CBD), has demonstrated anti-inflammatory and anti-oxidative effects in various studies. Our previous data showed that a low dosage of CBG reduced inflammation and fibrosis in male NASH mice. However, the impact of CBG on female mice remains unknown. Recent studies have identified changes in immune cell populations in NAFLD patients. The goal of this project was to test the impact of CBG treatment …

The Creation And Application Of A Fundamental Hip-Hop Curriculum: What Are The Benefits And Drawbacks Of Codifying Classic Hip-Hop Technique?, Julie Wolfrum

Master's Theses

In this study, the researcher proposed using knowledge collected of hip-hop dance experts and pioneers to create a curriculum applicable for the youth. Using interviews with various experts and research on hip-hop pioneers, the researcher tested the proposed curriculum on third, fourth, and fifth grade participants in a Colorado private school. The curriculum was tested over a span of five weeks with seventy-four participants. Within the study, the participants were given historical knowledge, various vocabulary, creative prompts, and were introduced to different hip-hop musical artists. The participants were required to participate in cyphers, Battles, various hip-hop dance exercises, and create …

Beaches, Bumps, And Milkshakes: A Humanizing, Open, And Dialogic, Postformal Autoethnographic Study Of An Experiential Learning Academy, Eric Anthony Karahalis

Theses & Dissertations

The dominant educational paradigm is rooted in a Platonic, Cartesian, and Piagetian mind-supremacist epistemology that subordinates the body and experience to the mind, ideas, and objective concepts. This reduces students to cognitive receptors of information in a detached, decontextualized, and dehumanizing classroom, i.e., the banking educational model (Freire, 2018; hooks,1994). Students are forced to sit at desks for several hours a day and expected to open their minds and ignore the body’s needs. This educational model is dehumanizing because it only approaches students and learning through one epistemological lens and separates learning from the world. On the other hand, experiential …

Program Development And Expansion Of A Clinician-Driven Wound Care Program At An Outpatient Wound Care Center, Zhenhai Niu

Doctor of Nursing Practice

Problem. Patients with chronic wounds often present with additional physical and emotional problems because healing of chronic wounds may require months to resolve. Practitioners develop treatment plans based on their own training and clinical expertise, but unfortunately, there are no universal guidelines to inform the management of chronic wounds. Expanding multi-factorial assessments and interventions could improve patient outcomes. The purpose of this project was to implement a wound care protocol for outpatient wound care clients based on a nutritional and psychological self-assessment. Methods. A patient-completed checklist, done on arrival to the clinic, triggered clinician-driven protocol interventions addressing mental health and …

Decades Of Don Quixote: Tracking Social Progression Through Marcela And Grisóstomo, Allison Jackson

Honors Theses

In this essay, I will track the evolution of academic opinions in the late 20th and early 21st century of two main components of the episode: Marcela’s character and what it says about Cervantes’ perception of women’s autonomy, as well as Grisóstomo’s death and the rejection of the notion of suicide by past academics. Marcela’s dramatic rejection of societal demands and Gristósomo’s tragic and confusing death are radically exciting since there is so much left to be assumed about the two main characters that is not explicitly written. The story relies on irony and subversion to enunciate a certain message; …

Examining The Microbial Diversity Of A Generalist Ant Along An Urban-Rural Gradient, Abdol-Munim Abazid

Honors Theses

After sampling the exoskeleton microbiomes of 225 ants from 3 different locations along a rural-urban gradient in the Chattanooga area, a photo library was collected and microbial diversity and morphospecies evenness of each location was determined. It was determined that there was no significant difference in either microbial diversity or morphospecies evenness between sites along the rural-urban gradient, even after adjusting data to be between only rural and urban areas. Urbanization was quantified using % impervious surface; however, a future study could quantify urbanization by other means, such as soil nutrient composition. Additionally, it was determined that there was no …

On The Causation Of The Mexican-American War, Emery Benson

Honors Theses

In 1844, Whig, former President, and then-Representative John Quincy Adams reflected on President John Tyler’s bill to annex Texas, writing about his anxiety over “the degeneracy of my country… under the transcendent power of slavery and the slave-representation.” Adams celebrated the treaty’s failure later that year, praising the nation’s escape from “slave-tainted monarchy, and of extinguished freedom.” In 1847, in the midst of the Mexican-American War, Reverend John Dudley of Vermont gave a fiery sermon in which he excoriated “the two leading sins of this nation, SLAVERY AND WAR.” Reverend Dudley continued, claiming “that the present war has its origin …

Criminal Law And Procedure, Lauren E. Brice, Michelle C. F. Derrico

University of Richmond Law Review

It has been another busy year in the General Assembly and in the appellate courts of Virginia, especially with the recently expanded Court of Appeals. Areas in which the General Assembly made significant changes are now filtering to the appellate courts for interpretation. There have been a number of significant opinions in retroactivity of statutes, probation violations, and mental health.

Taxation, Craig D. Bell

University of Richmond Law Review

This Article reviews significant recent developments in the laws affecting Virginia state and local taxation. Its Parts cover legislative activity, judicial decisions, and selected opinions from the past year. Part I of this Article addresses taxes administered by the Virginia Department of Taxation (the “Tax Department” or “Department”). Part II covers local taxes, including real and tangible personal property machinery and tools, license taxes, and other discrete local taxes.

The overall purpose of this Article is to provide Virginia tax and general practitioners with a concise overview of the recent developments in Virginia taxation that are most likely to impact …

From Blue Skies To Gray Areas: Examining Privacy And Property Law In The Age Of Drone Technology, Cheng-Chi (Kirin) Chang

Richmond Journal of Law & Technology

This article presents a comprehensive analysis of the legal frameworks governing the use of drones in both the United States and the European Union, and the privacy and property rights issues that arise from their use. The article emphasizes the importance of balancing the benefits of drone technology with the protection of individual rights. The regulatory frameworks governing drones are compared between the two jurisdictions, highlighting key similarities and differences. Furthermore, the article delves into the legal challenges surrounding drone usage and property rights, offering several solutions to address privacy concerns. In conclusion, the article highlights the need for a …

Using A Toxic Aging Coin To Assess Hexavalent Chromium-Induced Neurotoxicity., Samuel Thomas Vielee

Electronic Theses and Dissertations

We are facing an aging crisis, with 20% of the U.S. population projected to be geriatric (65+) by 2030 and live another 40+ years. Age-related diseases accompany a growing geriatric population, emphasizing the need to understand their etiology. Environmental pollutants compound this crisis by: 1) geriatrics are more susceptible, exacerbating age-related diseases and comorbidities, and 2) they accelerate biological aging, inducing age-related diseases at younger ages. We address this crisis using a ‘toxic aging coin’ approach; heads examines how age impacts toxicity, tails examines how chemicals accelerate aging. This thesis applies the heads side for Cr(VI)-induced neurotoxicity across ages. We …

Breaking Virulent: The Coincidental Evolution Of Virulence Factors In Bacteria., Rhiannon Emmanuelle Cecil

Electronic Theses and Dissertations

Understanding how innocuous organisms can evolve to be pathogenic to humans is of increasing global concern. Further, understanding how existing pathogens may evolved to be more virulent is also vital to our ability to provide healthcare to people afflicted with diseases that promote chronic bacterial infections, such as cystic fibrosis. With the rise of antibiotic resistance in both bacteria and fungi it is paramount that new therapeutics are identified. Understanding what mutations occur that result in increased virulence in microbes can potentially provide new targets for antimicrobial drugs to combat antibiotic resistance. The Coincidental Evolution Hypothesis is a fundamental hypothesis …

From "Smart Talk" To "Living Well": Commonplaces And Their Role In Narratives Of Rare Disease., Caitlin E. Ray

Electronic Theses and Dissertations

As healthcare becomes more complex, automated, and bureaucratic, patients often suffer from a lack of resources, agency, and visibility when seeking medical care. Rhetoric and Composition, specifically the subfield of Rhetoric of Health and Medicine (RHM), is interested in studying and intervening into such issues. One way to challenge our current understanding of healthcare is to consider how the rare disease patient experience reveals the gaps, limitations, and assumptions of illness and health. I argue here that through rare diseases, rhetoricians of health and medicine can better understand the representation, advocacy, and patient experience within healthcare, and potentially lead to …

Submandibular Salivary Gland Vulnerability: Unveiling Aflatoxin B1-Induced Toxicity And Rosmarinus Officinalis 'S Protective Role, Mohamed Shamel, Mahmoud Al Ankily, Mohamed Mansy, Robert Fua Angeles

Dentistry

No abstract provided.

U-Glide Program Fall 2023, Unf Office Of Undergraduate Research, Unf Graduate School

Undergraduate – Graduate Learning, Inquiry, and Distinctive Experimentation (U-GLIDE) Symposium Programs

No abstract provided.

Characterizing The Regulation Of Candida Albicans Hyphal Morphogenesis In The Context Of Host Macrophages, Hannah Wilson

Dissertations and Theses (Open Access)

Candida albicans is a commensal fungus that resides on the skin, mucosal surfaces, and in the gut of an estimated 80% of individuals. Though generally harmless, C. albicans is capable of causing uncomfortable mucosal infections as well as deadly disseminated infections depending on the immune status of the host. Although antifungal therapeutics exist, the mortality rate associated with disseminated disease still lingers around 50%. Further, C. albicans is the fourth most common cause of all bloodstream infections and continues to present as a major clinical issue with less than satisfactory treatment options. For this reason, it is imperative to understand …

Pathogenic Leptospira Are Widespread In The Urban Wildlife Of Southern California, Sarah K. Helman, Amanda F.N. Tokuyama, Riley O. Mummah, Nathan E. Stone, Mason W. Gamble, Celine E. Snedden, Benny Borremans, Ana C.R. Gomez, Caitlin Cox, Julianne Nussbaum, Isobel Tweedt, David A. Haake, Renee L. Galloway, Javier Monzón, Seth P.D. Riley, Jeff A. Sikich, Justin Brown, Anthony Friscia, Jason W. Sahl, David M. Wagner

All Faculty Open Access Publications

Leptospirosis, the most widespread zoonotic disease in the world, is broadly understudied in multi-host wildlife systems. Knowledge gaps regarding Leptospira circulation in wildlife, particularly in densely populated areas, contribute to frequent misdiagnoses in humans and domestic animals. We assessed Leptospira prevalence levels and risk factors in five target wildlife species across the greater Los Angeles region: striped skunks (Mephitis mephitis), raccoons (Procyon lotor), coyotes (Canis latrans), Virginia opossums (Didelphis virginiana), and fox squirrels (Sciurus niger). We sampled more than 960 individual animals, including over 700 from target species in the greater Los Angeles region, and an additional 266 sampled opportunistically …

Are Sheep And Plants The Future Of Solar? Oberlin College Agrivoltaic Project, Sydney Rosensaft

The Synapse: Intercollegiate science magazine

No abstract provided.

The Neural Manifold: Unfolding The Matrix Of Our Brain, James Lee

The Synapse: Intercollegiate science magazine

No abstract provided.

Issue 38

The Synapse: Intercollegiate science magazine

No abstract provided.

Computational Molecular Docking Studies Of Small Molecule Inhibitors With The Sars-Cov-2 Spike Protein Variants: In-Silico Drug Discovery Using Virtual Screening And Drug Repurposing Approaches, Grace Gupta

Computational and Data Sciences (MS) Theses

The pandemic caused by the emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019 has caused a global public health crisis of nearly unprecedented scale. In the years following the outbreak, the scientific community has mobilized to develop several vaccines and treatments. Drug repurposing as a strategy for drug development has produced many of the current therapeutic options. The greatest challenge to designing a therapeutic inhibitor of SARS-CoV-2 is the shifting mutational landscape of the virus as it evolves. In this study, we focus on the spike protein as a target for potential inhibitors. We explore two …

Clemson University Board Of Trustees, Special Board Meeting, 2023 December 1, Clemson University Board Of Trustees

Minutes

No abstract provided.

Phylogenomics Reveals The History Of Host Use In Mosquitoes, John Soghigan, Charles Sither, Silvia Andrade Justi, Gen Morinaga, Brian K. Cassel, Christopher J. Vitek, Todd P. Livdahl, Siyang Xia, Andrea Gloria-Soria, Jeffrey R. Powell, Thomas Zavortink, Christopher M. Hardy, Nathan D. Burkett-Cadena, Lawrence E. Reeves, Richard C. Wilkerson, Robert R. Dunn, David K. Yeates, Maria Anice Sallum, Brian D. Byrd, Michelle D. Trautwein, Yvonne-Marie Linton, Michael H. Reiskind, Brian M. Wiegmann

Biology

Mosquitoes have profoundly affected human history and continue to threaten human health through the transmission of a diverse array of pathogens. The phylogeny of mosquitoes has remained poorly characterized due to difficulty in taxonomic sampling and limited availability of genomic data beyond the most important vector species. Here, we used phylogenomic analysis of 709 single copy ortholog groups from 256 mosquito species to produce a strongly supported phylogeny that resolves the position of the major disease vector species and the major mosquito lineages. Our analyses support an origin of mosquitoes in the early Triassic (217 MYA [highest posterior density region: …