Digital Commons Network^™

Structure And Dynamics That Specialize Neurons For High-Frequency Coincidence Detection In The Barn Owl Nucleus Laminaris, Ben Drucker , '22, Joshua H. Goldwyn

Mathematics & Statistics Faculty Works

A principal cue for sound source localization is the difference in arrival times of sounds at an animal’s two ears (interaural time difference, ITD). Neurons that process ITDs are specialized to compare the timing of inputs with submillisecond precision. In the barn owl, ITD processing begins in the nucleus laminaris (NL) region of the auditory brain stem. Remarkably, NL neurons are sensitive to ITDs in high-frequency sounds (kilohertz-range). This contrasts with ITD-based sound localization in analogous regions in mammals where ITD sensitivity is typically restricted to lower-frequency sounds. Guided by previous experiments and modeling studies of tone-evoked responses of NL …

Assessing The Bioavailability Of Infused Lysine And Rumen-Protected Lysine Supplements Using The Area Under The Curve Technique And The Plasma Free Amino Acid Dose-Response Method, Megan Vetter

Honors Theses and Capstones

The milk production of lactating dairy cows is dependent on factors such as housing conditions, lineage, climate, and health, but the quality of their diets is generally the most influential. Maintaining a proper balance of nutrients is necessary to achieve the greatest milk production at the lowest cost. Maximum feed efficiency is not only critical for increasing the economic profits of an individual farm, but also for increasing food supply without increasing environmental demand. Supplementing cows’ diets with lysine (Lys), an essential amino acid (AA), can aid in maximizing protein synthesis. Providing this nutrient in a rumen-protected (RP) coating can …

Groundwater Dynamics In An Unconfined Coastal Aquifer: Geophysical Investigations And Modeling, Jeeban Panthi

Open Access Dissertations

Coastal groundwater plays a vital role in the sustainability of coastal ecosystems and the freshwater supply for over one billion people worldwide. Understanding the movement and interaction of saltwater and freshwater in coastal aquifers is crucial for effective water resource management. The interface between these density-contrast waters is highly dynamic and sensitive to natural drivers, such as sea level rise, storm surges, and drought, as well as anthropogenic factors, including groundwater over-pumping. In recent years, the drivers of coastal groundwater dynamics have been increasingly well understood and quantified. However, there is a need for data-model fusion, including integrating different forms …

Utilization Of Large-Scale Genomic Data And Phylogenetic Methods In Studying Evolutionary Radiations, Eren Ada

Open Access Dissertations

The remarkable biodiversity of the Earth fascinated natural scientists for centuries. Studying this biodiversity has been a major occupation of the life sciences because deciphering the underlying biological mechanisms of diversification provides fundamental knowledge for biological evolution. A significant body of evidence shows that today’s biodiversity originated from successive adaptive diversification periods (i.e.: evolutionary radiations) which are generally characterized by the rapid multiplication of lineages with a variety of adaptations and ecological roles. Some of the most well-known examples of evolutionary radiations include the striking wing pattern diversity of Heliconius butterflies, the great body form variety of Caribbean anole lizards, …

Optimization Of Envelope Heat Gain And Interior Daylight Illuminance In Building Facade Design Under Reflectance Limitations : A Case Study Of Office Buildings In Thailand, Sarin Pinich, Kantaphong Srimuang, Atch Sreshthaputra

NAKHARA (Journal of Environmental Design and Planning)

The popularity of using glass as the main building envelope material in commercial high-rise buildings has brought about numerous legal actions in recent years due to the widespread impact of the visible light reflectance of glass facades on the surrounding area. However, choosing suitable reflectance values for glazing the building facade remains a viable solution to lessen envelope heat gain and reduce cooling energy demand. Despite this, maximizing daylight is essential to maintaining healthy vision and the circadian rhythm of the building users. As a result, finding the optimal solution for envelope glass property selection to provide minimum heat gain …

New Frontiers In Technology: Can Traditional Intellectual Property Rights Laws Be Adapted And Applied To Nfts?, Mariyah S. Wakhariya

Catholic University Journal of Law and Technology

A decade ago, ‘NFTs’ were rarely heard of or known to anyone, unless they worked in or kept up with the tech world. However, they are not new - they have been around for almost two decades. Their popularity has grown over the past few years. ‘NFT’ stands for ‘non-fungible token’. An NFT is a digital file with a unique identity that is verified on a blockchain and is therefore not interchangeable - i.e., a kind of crypto asset, like an authentication certificate for digital artifacts. In theory, NFTs can represent almost any real or intangible property. These days, it …

Maternal Obesity Blunts Antimicrobial Responses In Fetal Monocytes, Suhas Sureshchandra, Brianna M. Doratt, Norma Mendza, Oleg Varlamov, Monica Rincon, Nicole E. Marshall, Ilhem Messaoudi

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Maternal pre-pregnancy (pregravid) obesity is associated with adverse outcomes for both mother and offspring. Amongst the complications for the offspring is increased susceptibility and severity of neonatal infections necessitating admission to the intensive care unit, notably bacterial sepsis and enterocolitis. Previous studies have reported aberrant responses to LPS and polyclonal stimulation by umbilical cord blood monocytes that were mediated by alterations in the epigenome. In this study, we show that pregravid obesity dysregulates umbilical cord blood monocyte responses to bacterial and viral pathogens. Specifically, interferon-stimulated gene expression and inflammatory responses to respiratory syncytial virus (RSV) and E. coli were significantly …

Single-Dose Vsv-Based Vaccine Protects Cynomolgus Macaques From Disease After Taï Forest Virus Infection, Paige Fletcher, Kyle L. O'Donnell, Brianna M. Doratt, Delphine C. Malherbe, Chad S. Clancy, Joseph F. Rhoderick, Friederike Feldmann, Patrick W. Hanley, Thomas G. Ksiazek, Thomas W. Geisbert, Ilhem Messaoudi, Andrea Marzi

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Taï Forest virus (TAFV) is a lesser-known ebolavirus that causes lethal infections in chimpanzees and is responsible for a single human case. Limited research has been done on this human pathogen; however, with the recent emergence of filoviruses in West Africa, further investigation and countermeasure development against this virus is warranted. We developed a vesicular stomatitis virus (VSV)-based vaccine expressing the TAFV glycoprotein as the viral antigen and assessed it for protective efficacy in nonhuman primates (NHPs). Following a single high-dose vaccination, NHPs developed antigen-specific binding and neutralizing antibodies as well as modest T cell responses. Importantly, all vaccinated NHPs …

Transcriptional Profiling Of Immune Responses In Nhps After Low-Dose, Vsv-Based Vaccination Against Marburg Virus, Cecilia A. Prator, Brianna M. Doratt, Kyle L. O'Donnell, Justin Lack, Amanda N. Pinski, Stacy M. Ricklefs, Craig A. Martens, Ilhem Messaoudi, Andrea Marzi

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Infection with Marburg virus (MARV), the causative agent of Marburg virus disease (MVD), results in haemorrhagic disease and high case fatality rates (>40%) in humans. Despite its public health relevance, there are no licensed vaccines or therapeutics to prevent or treat MVD. A vesicular stomatitis virus (VSV)-based vaccine expressing the MARV glycoprotein (VSV-MARV) is currently in clinical development. Previously, a single 10 million PFU dose of VSV-MARV administered 1–5 weeks before lethal MARV challenge conferred uniform protection in nonhuman primates (NHPs), demonstrating fast-acting potential. Additionally, our group recently demonstrated that even a low dose VSV-MARV (1000 PFU) protected NHPs …

Platelet Glycogenolysis Is Important For Energy Production And Function, Kanakanagavalli Shravani Prakhya, Hemendra J. Vekaria, Daniёlle M. Coenen, Linda Omali, Joshua Lykins, Smita Joshi, Hammodah Rawhi Hammodah Alfar, Qing Jun Wang, Patrick G. Sullivan, Sidney W. Whiteheart

Saha Cardiovascular Research Center Faculty Publications

Although the presence of glycogen in platelets was established in the 1960s, its importance to specific functions (i.e., activation, secretion, aggregation, and clot contraction) remains unclear. Patients with glycogen storage disease often present with increased bleeding and glycogen phosphorylase (GP) inhibitors, when used as treatments for diabetes, induce bleeding in preclinical studies suggesting some role for this form of glucose in hemostasis. In the present work, we examined how glycogen mobilization affects platelet function using GP inhibitors (CP316819 and CP91149) and a battery of ex vivo assays. Blocking GP activity increased glycogen levels in resting and thrombin-activated platelets and inhibited …

The Complementary Roles Of Vamp-2, -3, And -7 In Platelet Secretion And Function, Smita Joshi, Kanakanagavalli Shravani Prakhya, Alexis N. Smith, Harry Chanzu, Ming Zhang, Sidney W. Whiteheart

Saha Cardiovascular Research Center Faculty Publications

Platelet secretion requires Soluble N-ethylmaleimide Sensitive Attachment Protein Receptors (SNAREs). Vesicle SNAREs/Vesicle-Associated Membrane Proteins (v-SNAREs/ VAMPs) on granules and t-SNAREs in plasma membranes mediate granule release. Platelet VAMP heterogeneity has complicated the assessment of how/if each is used and affects hemostasis. To address the importance of VAMP-7 (V7), we analyzed mice with global deletions of V3 and V7 together or platelet-specific deletions of V2, V3, and global deletion of V7. We measured the kinetics of cargo release, and its effects on three injury models to define the context-specific roles of these VAMPs. Loss of V7 minimally affected dense and α …

Best3-Mediated Mekk2/3 Activation: A Novel Therapeutic Target In Aortopathies, Tatiana Zyrianova, Benjamin Lopez, Kathlyn Zou, Charles Gu, Dayna Pham, Sriharsha Talapaneni, Christopher M. Waters, Riccardo Olcese, Andreas Schwingshackl

Saha Cardiovascular Research Center Faculty Publications

Influenza-A virus (IAV) infects yearly an estimated one billion people worldwide, resulting in 300,000–650,000 deaths. Preventive vaccination programs and antiviral medications represent the mainstay of therapy, but with unacceptably high morbidity and mortality rates, new targeted therapeutic approaches are urgently needed. Since inflammatory processes are commonly associated with measurable changes in the cell membrane potential (Em), we investigated whether Em hyperpolarization via TREK-1 (K2P 2.1) K þ channel activation can protect against influenza-A virus (IAV)-induced pneumonia. We infected mice with IAV, which after 5 days caused 10–15% weight loss and a decrease in spontaneous activity, representing a clinically relevant infection. …

Deep Learning, 3d Ultrastructural Analysis Reveals Quantitative Differences In Platelet And Organelle Packing In Covid-19/Sarscov2 Patient-Derived Platelets, Sagar S. Matharu, Cassidy S. Nordmann, Kurtis R. Ottman, Rahul Akkem, Douglas Palumbo, Denzel R. D. Cruz, Kenneth Campbell, Gail Sievert, Jamie L. Sturgill, James Zachary Porterfield, Smita Joshi, Hammodah Rawhi Hammodah Alfar, Chi Peng, Irina D. Pokrovskaya, Jeffrey A. Kamykowski, Jeremy P. Wood, Beth A. Garvy, Maria A. Aronova, Sidney W. Whiteheart, Richard D. Leapman, Brian Storrie

Saha Cardiovascular Research Center Faculty Publications

Platelets contribute to COVID-19 clinical manifestations, of which microclotting in the pulmonary vasculature has been a prominent symptom. To investigate the potential diagnostic contributions of overall platelet morphology and their α-granules and mitochondria to the understanding of platelet hyperactivation and micro-clotting, we undertook a 3D ultrastructural approach. Because differences might be small, we used the high-contrast, high-resolution technique of focused ion beam scanning EM (FIB-SEM) and employed deep learning computational methods to evaluate nearly 600 individual platelets and 30 000 included organelles within three healthy controls and three severely ill COVID-19 patients. Statistical analysis reveals that the α-granule/ mitochondrion-to-plateletvolume ratio …

Lrp1 Protects Against Excessive Superior Mesenteric Artery Remodeling By Modulating Angiotensin Ii–Mediated Signaling, Jackie M. Zhang, Dianaly T. Au, Hisashi Sawada, Michael K. Franklin, Jessica J. Moorleghen, Deborah A. Howatt, Pengjun Wang, Brittany O. Aicher, Brian Hampton, Mary Migliorini, Fenge Ni, Adam E. Mullick, Mashhood M. Wani, Areck A. Ucuzian, Hong S. Lu, Selen C. Muratoglu, Alan Daugherty, Dudley K. Strickland

Saha Cardiovascular Research Center Faculty Publications

Vascular smooth muscle cells (vSMCs) exert a critical role in sensing and maintaining vascular integrity. These cells abundantly express the low-density lipoprotein receptor–related protein 1 (LRP1), a large endocytic signaling receptor that recognizes numerous ligands, including apolipoprotein E–rich lipoproteins, proteases, and protease-inhibitor complexes. We observed the spontaneous formation of aneurysms in the superior mesenteric artery (SMA) of both male and female mice in which LRP1 was genetically deleted in vSMCs (smLRP1–/– mice). Quantitative proteomics revealed elevated abundance of several proteins in smLRP1–/– mice that are known to be induced by angiotensin II–mediated (AngII-mediated) signaling, suggesting that this pathway was dysregulated. …

Macrophage Angiotensin-Converting Enzyme Reduces Atherosclerosis By Increasing Peroxisome Proliferator-Activated Receptor Α And Fundamentally Changing Lipid Metabolism, Duoyao Cao, Zakir Khan, Xiaomo Li, Suguru Saito, Ellen A. Bernstein, Aaron R. Victor, Faizan Ahmed, Aoi O. Hoshi, Luciana C. Veiras, Tomohiro Shibata, Mingtian Che, Lei Cai, Michifumi Yamashita, Ryan E. Temel, Jorge F. Giani, Daniel J. Luthringer, Ajit S. Divakaruni, Derick Okwan-Duodu, Kenneth E. Bernstein

Saha Cardiovascular Research Center Faculty Publications

Aims The metabolic failure of macrophages to adequately process lipid is central to the aetiology of atherosclerosis. Here, we examine the role of macrophage angiotensin-converting enzyme (ACE) in a mouse model of PCSK9-induced atherosclerosis.

Methods and results Atherosclerosis in mice was induced with AAV-PCSK9 and a high-fat diet. Animals with increased macrophage ACE (ACE 10/10 mice) have a marked reduction in atherosclerosis vs. WT mice. Macrophages from both the aorta and peritoneum of ACE 10/10 express increased PPARα and have a profoundly altered phenotype to process lipids characterized by higher levels of the surface scavenger receptor CD36, increased uptake of …

The Guardian The Month Of January 2023, Wright State Student Body

The Guardian Student Newspaper

News articles from The Guardian for the Month of January 2023. The Guardian is the official student-run newspaper for Wright State University. It has been published regularly since March of 1965.

Impacts Of Viral Infection By Ma-Lmm01 On Microcystin Production By Microcystis Aeruginosa, Amber Elizabeth Haley

Senior Honors Theses and Projects

Increasing global temperatures and nutrient availability from anthropogenic sources have contributed to climate change and pollution in waterways. Environmental changes have promoted annual harmful algal blooms (HABs), which have the potential to lead to conditions that negatively affect aquatic ecosystems and organisms that depend on them. HABs can impact water quality through the release of soluble toxins (e.g., microcystin), produced by cyanobacteria that can bypass standard drinking water processing protocols. It has been suggested that viral infections of cyanobacteria may contribute to increased production and release of microcystins. In this project, two hypotheses were assessed: 1) virus-mediated lysis releases toxins …

Ipulse: January 2023, Lynn University

Student Newspapers

Issues:

• January 2023 [Spring Week #1]: The Launch of iPulse Live; Holy Shakes Has Decadent & Indulgent Treats; Power Through the Day with a Full Night's Rest; Laundry Tips for College Students; A Place For Everyone; A Journey Beyond College
• January 2023 [Spring Week #2]: Meet the iPulse Staff

Neoichnological Framework Of Coastal Habitat Shifts Represented By Bahamian Decapod Burrows, Ilya Val Buynevich, Karen Kopcznski, Christopher Sparacio, H. Allen Curran

Geosciences: Faculty Publications

In coastal settings, the cumulative spatial and temporal impacts of burrowing, ichnofabric formation, and biodeposition by large crustaceans have been largely neglected at zoogeomorphic scales. These traces also serve as important (paleo-)environmental and (paleo)hydrologic indicators, both vertical (tidal or groundwater level) and lateral (areal wetland or basin extent). To date, 354 only few studies have addressed the comparative value of decapod ichnites generated by land crabs in carbonate settings. The aim of this paper is to introduce a general conceptual framework for burrows created by three crab species in the Bahama Archipelago, using examples from San Salvador Island.

The Complex Regional Pain Syndrome: Diagnosis And Management Strategies, Fahad S. Alshehri

Neurosciences

Complex regional pain syndrome (CRPS) is a chronic disease that affects a limb following an injury or trauma. The CRPS associated with symptoms, including severe pain, swelling, as well as changes in skin color and temperature. Treatment of CRPS requires a multidisciplinary approach, with a focus on personalized treatment plans and addressing psychological factors. This review provides an overview of updates in the diagnosis and treatment of CRPS. There are clinical criteria for diagnosing CRPS, including persistent pain and swelling. The CRPS can also be diagnosed with imaging and laboratory tests. Novel insights into treatment approaches for CRPS have been …

Cerebral Phaeohyphomycosis At A Tertiary Healthcare Center In Saudi Arabia, Mayyadah H. Alabdely, Abdullah S. Alolayan, Reem S. Almaghrabi, Hail M. Al-Abdely

Neurosciences

Objectives: To report cases of cerebral phaeohyphomycosis at a tertiary hospital in Riyadh, Saudi Arabia. Phaeohyphomycetes are a widely distributed group of fungi whose cell walls contain 1,8 dihydroxynaphthalene-melanin. Cerebral infections caused by these fungi are uncommon and primarily associated with neurotrophic phaeohyphomycetes. Methods: In January of 2020 we looked back to identify cases of culture-positive cerebral phaeohyphomycosis from our medical records at King Faisal Specialist Hospital and Research Center in Riyadh, Saudi Arabia. Data on demographics, potential risk factors, clinical presentation, treatment, and outcomes were analyzed. Results: Twelve cases of cerebral phaeohyphomycosis were identified, of which 4 were caused …

Higher Education Student Perceptions Regarding The Practice Of Telemental Health Services In Kingdom Of Saudi Arabia, Bussma A. Bugis, Leena Z. Alzayed, Manar H. Bin Helabi, Heba A. Alqurashi

Neurosciences

Objectives: To study higher education student perceptions regarding the practice of telemental health services in Saudi Arabia. Methods: The study conducted a cross-sectional descriptive design through an online self-administered survey. The targeted number of responses was set to at least 385 convenience-sample students who were enrolled in different degree programs at the selected university for the Spring 2022 semester. Data collection was done during March 2022. Results: The sample population was 401 eligible responses. Most respondents Most respondents were from Riyadh (39.15%), females (66.33%), single (64.83%) at the time of data collection. Forty-five percent of participants did not use any …

Hemorrhagic Fever With Renal Syndrome And Reversible Splenial Lesion Syndrome, Xulei Zhang, Yimin Ma, Renchen Cai, Zhenguo Qiao

Neurosciences

Hemorrhagic fever with renal syndrome (HFRS) and reversible splenial lesion syndrome are both considered uncommon conditions relatively rare. Fever, hemorrhage, and acute kidney injury are the prevailing symptoms frequently observed in cases of HFRS. We describe a case of a middle-aged man who had been hospitalized with fever and acute neurological symptoms. His main symptom was recurrent dizziness. Cranial computed tomography (CT) did not reveal any obvious lesions, such as encephalorrhagia or infarctions. The splenium of corpus callosum showed hyperintensity on brain magnetic resonance imaging (MRI), which is in line with the characteristic radiographic observations of reversible splenial lesion syndrome …

Site, Sight, Swipe, Prada Marfa: A Case Study In Public Art, Cultural Tourism, And Image-Based Social Media Engagement, Ha'ani Joy Hogan

Graduate Thesis and Dissertation 2023-2024

Through a case study of Prada Marfa, a site-specific public art sculpture located in West Texas, this dissertation examines the connection of public art, cultural tourism, and image-based social media engagement. Little scholarship that combines all three areas of study exists. To fill this gap, this study incorporates five methods of research to determine how one public art sculpture's existence can contribute to its surrounding community by prompting economic activity and influencing the way that community is seen through a public lens. The five methods encompass a historical analysis of news articles about The City of Marfa and Prada …

Activist-Casual Game Design: Iterating Serious Games Through Research-Creation, Daniel J. King

Graduate Thesis and Dissertation 2023-2024

How can activists and scholars design serious game projects that attract and engage people, that are inviting for many types of players, and that empower players to create positive change? My hypothesis was that the Activist-Casual Game Design Framework I published in 2021 could facilitate this work. I took a design-based research approach to answer my research question by way of demonstration and self-reflection through a creative case study of the production of an activist-casual game called Climate Somnia. Chapter 1 explains the literature review and synthesis behind the creation of the original framework, and Chapter 2 reviews the …

Economic Values, Social Values And Cultural Animal Theory, Kevin Smith

Department of Political Science: Faculty Publications

Baumeister and Bushman (this issue: Psychological Inquiry 2023, vol. 34, no. 1) offer a cultural animal theory of partisan hostility (hereafter CAT) with the specific aim of explaining the root drivers of political conflict. CAT posits that competition for power revolves around oppositional worldviews reflecting preferences attached to the two primary objectives of all successful societies: amassing and distributing resources. Based on this premise CAT seeks not only to help explain the persistence of the themes motivating political conflict, but also to shed light on the underlying causes of growing levels affective polarization widely documented in the United States and …

First Record Of The Occurrence Of The Chinese Pond Mussel Sinanodonta Woodiana (Lea, 1834) (Bivalvia: Unionidae) In African Freshwaters: Oubeira Lake, Algeria, Lamia Bensaad-Bendjedid, Salah Telailia, Faiza Alliouche, Hassen Touati, Imen Ladjama

Turkish Journal of Zoology

The Chinese pond mussel Sinanodonta woodiana (Lea, 1834) (Bivalvia: Unionidae) is among the most invasive freshwater species worldwide. The last decades have seen its rapid geographical spread beyond the species' natural range, particularly in anthropogenically modified water bodies across Asia, America, and Europe where it is now very common. In this paper, we also confirm the presence of S. woodiana in Africa (Algeria) by establishing the UNESCO Biosphere Reserve and Ramsar site Oubeira Lake as a new locality for its occurrence. In all likelihood, S. woodiana was accidentally introduced in the 1980s with Asian fish species imported from Hungary for …

Biodiversity Of Mosquitoes (Diptera: Culicidae), Vectors Of Important Arboviral Diseases At Different Altitudes In The Central Part Of Iran, Azim Paksa, Mozaffar Vahedi, Saideh Yousefi, Nasrollah Saberi, Sara Rahimi, Masoumeh Amin

Turkish Journal of Zoology

Risk assessment and vector control programs rely on a comprehensive knowledge of mosquito diversity in different areas. The present study aims to evaluate mosquito biodiversity in different areas of Sirjan County, Kerman Province, as one of the most important economic zones of Iran. Totally 4538 mosquitoes representing 19 species and four genera were collected and identified. Results showed that Culiseta longiareolata and Culex quinquefacsiatus were constant, Culex destricola, Culex pusillus, Culex pipiens and Culex laticinctus were common and the other captured species were accidental species in Sirjan County. In this study, Aedes vittatus was recorded for the first time in …

Condition Factor And Length-Weight Relationships Evaluation Of 15 Oxynoemacheilus Species (Cypriniformes: Nemacheilidae) From Iran, Atta Mouludi-Saleh, Soheil Eagderi, Erdoğan Çi̇çek, Edris Ghaderi

Turkish Journal of Zoology

This study was conducted to determine the relationship between the length and weight (LWR) of 15 Oxynoemacheilus species i.e. Oxynoemacheilus bergianus, O. brandtii, O. chomanicus, O. euphraticus, O. elsae, O. frenatus, O. karunensis, O. kiabii, O. kurdistanicus, O. longipinnis, O. parvinae, O. persa, O. marunensis, O. zagrosensis, and O. zarzianus from Iranian inland waters. LWRs with high coefficients of determination were calculated for all species. The values of the slope parameter (b) ranged from 2.225 in O. brandtii to 3.575 in O. euphraticus. Fulton's condition factor (K$_{F}$) ranged from 0.673 in O. persa to 1.407 in O. kiabili …

Cover And Contents

Turkish Journal of Zoology

No abstract provided.