Digital Commons Network^™

Targeting The Pai-1 Mechanism With A Small Peptide Increases The Efficacy Of Alteplase In A Rabbit Model Of Chronic Empyema, Galina Florova, Christian J. De Vera, Rebekah L. Emerine, Rene A. Girard, Ali Azghani, Krishna Sarva, Jincy Jacob, Danna E. Morris, Mignote Chamiso, Steven Idell, Andrey A. Komissarov

School of Medical and Biological Sciences Faculty Publications and Presentations

The incidence of empyema is increasing and associated with a mortality rate of 20% in patients older than 65 years. Since 30% of patients with advanced empyema have contraindications to surgical treatment, novel, low-dose, pharmacological treatments are needed. A Streptococcus pneumoniae-induced rabbit model of chronic empyema recapitulates the progression, loculation, fibrotic repair, and pleural thickening of human disease. Treatment with single chain (sc) urokinase (scuPA) or tissue type (sctPA) plasminogen activators in doses 1.0–4.0 mg/kg were only partially effective in this model. Docking Site Peptide (DSP; 8.0 mg/kg), which decreased the dose of sctPA for successful fibrinolytic therapy in acute …

A Job Guarantee: Student Ideas, Zdravka Todorova, Shannon Parisi, Patrick Lockhart, Brad Kerry, Jeremy A. Ocampo, Divya Sharma, James Curlis, Tristan Walters

Student Papers in Local and Global Regional Economies

This paper presents students’ ideas for job guarantee public service projects, developed in a Master's level course, Economic Social and Ecological Systems. Seven student proposals address local issues and their economic, social, and ecological aspects. The proposals build on social costs, stratification, and commodification; and identify locally needed public service jobs not provided by the business sector. As part of a federally funded, locally designed, and administered job guarantee program, they expand and improve public and non-profit sectors. The article describes the course and its focus on integrated systems, as well as the pedagogy of building on students’ interests, concerns, …

Festival Of Research Abstracts, 2023, College Of Science And Mathematics, Wright State University

Festival of Research

The collection of abstracts accepted for the 2023 Festival of Research hosted by the Wright State University College of Science and Mathematics.

Cls 2040 Great Books - Classics Core General Education Assessment, 2023-2024, College Of Liberal Arts, Wright State University

Core General Education Assessments - All

This report assesses Wright State University's course CLS 2040, Great Books - Classics, as part of the institution’s ongoing general education Core assessment plan.

Migrants, Covid-19, And Italy: A Multimodal Critical Discourse Analysis Of The Construction Of And Resistance To Nationalist Discourses, Alessia Barbici Wagner, Theresa Catalano, Bryan Meadows

Department of Teaching, Learning, and Teacher Education: Faculty Publications

Migration has historically been a controversial issue around the world and one that has often been harnessed by people in power (or people hoping to gain power) for their own political agendas. In times of a global pandemic, the scapegoating of migrants has only increased, often rooted in nationalist ideologies which lead to policies and practices that harm migrants and the larger society. The present paper employs multimodal critical discourse analysis to explore how nationalist ideologies supported by right-wing populism are constructed visually and verbally during COVID-19 on Italian social media in regard to migration. We analyze Giorgia Meloni’s (leader …

From Bilingual To Biliteracy: Learning From Families, Stephanie Wessels, Guy Trainin

Department of Teaching, Learning, and Teacher Education: Faculty Publications

This study examined the home literacy practices of bilingual families. We were specifically interested in the literacy practices families developed to answer the challenge of biliteracy. Through the home visits and supplying high quality bilingual books, we listened, observed, and gained a deeper understanding of the children and their families which allowed us and educators reading this piece to make connections between children’s home literacy practices and literacy practices in the classroom. After discussing the use of bilingual books, the following four themes emerged from the data: families negotiating biliteracy using bilingual books, the role of Spanish, siblings and literacy …

Creating Light At Tunnel’S End: Ukraine’S Post-War Urban Recovery, Russell W. Glenn

Journal of Strategic Security

The US response to Iraq’s recovery in the aftermath of 2003 Operation Iraqi Freedom suffered from an initial conclusion that it was the country’s petroleum infrastructure rather than its electrical networks that were in greater need of recovery resources. The resulting misallocation of resources delayed power restoration to much of the country and frustrated those in affected regions.

Whether the cause is war or a catastrophe sparked by Mother Nature, accurately identifying and correctly prioritizing post-disaster requirements is fundamental to an effective and efficient response. Ukraine has demonstrated a commendable ability to repair war damage even as conflict continues, but …

Seasonal Diversity Of Spider Assemblages (Araneae: Arachnida) In The “Guillermo Piñeres” Botanical Garden, Turbaco–Colombia, Wilder Zapata, David Vergara-Moreno, Martín Carrillo-Pallares, Alejandro Segovia-Paccini, Gabriel R. Navas S., Jagoba Malumbres-Olarte

Neotropical Biodiversity

No abstract provided.

Can Marketing Transcend Entrenched Gender Biases?, Thinh Nguyen

Marketing Faculty Publications

Through a feminist lens, Maclaran and Chatzidakis (2022) challenge conventional assumptions about gender, emphasizing its performative nature shaped by social practices rather than inherent traits. This commentary extends analyses of key themes such as gender performativity, the male gaze, and subject-object binaries within marketing. It critiques how marketing strategies reinforce existing power imbalances and systemic biases rooted in historical narratives. The writing also reflects on media interpretations of gender issues through films like 'Turning Red' and 'Barbie'. By contextualizing gendered marketing within broader societal frameworks, this writing contributes to ongoing dialogues in media studies, sociology, and gender studies, highlighting the …

The New Fourth Era Of American Religious Freedom, John Witte Jr., Eric Wang

Faculty Articles

The U.S. Supreme Court has entered decisively into a new fourth era of American religious freedom. In the first era, from 1776 to 1940, the Court largely left governance of religious freedom to the individual states and did little to enforce the First Amendment Religion Clauses. In the second era, from 1940 to 1990, the Court “incorporated” the First Amendment into the Fourteenth Amendment Due Process Clause and applied both a strong Free Exercise Clause and a strong Establishment Clause against federal, state, and local governments alike. In the third era, from the mid-1980s to 2010, the Court softened the …

Thinly Rooted: Dobbs, Tradition, And Reproductive Justice, Darren L. Hutchinson

Faculty Articles

In Dobbs v. Jackson Women’s Health Organization, the Supreme Court overruled Roe v. Wade and Planned Parenthood of Southeastern Pennsylvania v. Casey. These two cases held that the Due Process Clause of the Fourteenth Amendment encompassed a right of women to terminate a pregnancy. Roe reflected over 60 years of substantive due process precedent finding and reaffirming a constitutional right of privacy with several animating themes, including bodily integrity, equality, and dignity. The Court’s substantive due process doctrine had established that the analysis in such cases would involve multiple points of inquiry, such as tradition, contemporary practices, and …

The Effects Of Nausea And Vomiting On Mother And Child, Mayane Bensoussan

The Science Journal of the Lander College of Arts and Sciences

Nausea and vomiting are common side effects that can occur during pregnancy. On one hand, it can lead to its severe form called hyperemesis gravidarum, which can lead to hospitalization for electrolyte imbalances, dehydration, muscle weakness, or arrhythmias. On the other hand, nausea and vomiting may be an indication of a statistically healthier fetus. Benefits of maternal nausea and emesis to the developing fetus include improved neural development, decreased risk for congenital heart defects, and decreased incidence of miscarriages. Additionally, benefits to the mother include decreased risk for lung, cervical, and rectal cancer. The mothers also had an overall decreased …

Effects Of Microdosing With Psilocybin Mushrooms, Chavivah Davis

The Science Journal of the Lander College of Arts and Sciences

Microdosing with psilocybin, a psychoactive compound found in certain species of mushrooms, has gained popularity in recent years as a means of enhancing mood, cognition, and creativity without inducing the full-blown psychedelic experience. There are many potential benefits associated with microdosing with psilocybin. Although studies do show many positive effects of microdosing with psilocybin, long-term research is required to make a conclusive statement regarding this topic. Furthermore, there are risks and concerns involved that need to be considered, including the illegality of psilocybin and the lack of research. This paper will review the available literature on microdosing with psilocybin. It …

Epinephrine And Cardiac Arrest: The Catch-22, Shaina Friedman

The Science Journal of the Lander College of Arts and Sciences

Epinephrine has been a standard of care treatment for cardiac arrest for the last century; however, the use of epinephrine began without a significant amount of research. In recent years, many have started to question whether epinephrine is an appropriate treatment for cardiac arrest. While epinephrine causes vasoconstriction of the blood vessels and directs much-needed blood flow to the heart, it has also been shown to harm the microvessels of the brain, causing ischemia and neurological damage. Many trials, studies, and surveys were conducted to determine the correct course of action involving the use of epinephrine during cardiac arrest. Additional …

The Impact Of Maternal Health On Breastfeeding Duration, Yael Weinberg

The Science Journal of the Lander College of Arts and Sciences

The mechanism of breastfeeding is a complex biological process beginning with hormone production from the pituitary gland and ending with the ejection of milk from the breasts. Mothers are recommended to breastfeed exclusively for six months and then continue for another six with the addition of solid food. However, despite the countless health benefits associated with lengthened breastfeeding for both mother and infant, many women dismiss this recommendation. This paper aims to research the aspects of maternal health that can derail the recommended duration of breastfeeding, focusing on emotional health, nutritional intake, and various diseases or surgeries. It is found …

Do The Benefits Of Growth Hormone Outweigh The Risks?, Michael D. Goodstein

The Science Journal of the Lander College of Arts and Sciences

Growth hormone treatment was introduced in the 1950s to confront growth hormone deficiency and metabolic irregularities. In 2003, however, the FDA approved growth hormone treatment for patients with abnormal growth rates unlinked to growth hormone deficiency. The treatment has become largely available to the general public, making the safety of growth hormone treatment an extremely important subject. This paper clarifies the benefits and efficacy of growth hormone treatment and analyzes the potential associated risks, including cancer and diabetes.

Smells Like Money: A Proposal To Re-Examine The Illinois Right-To-Farm Act, Callah Wright

Southern Illinois University Law Journal

Since 1973, every state has passed a Right-to-Farm Act (“RTFA”). These Acts are in place to (1) strengthen the legal position of farmers when neighbors take legal action for private nuisance; and (2) to protect farmers from local and state ordinances that restrict agriculture production. This Note argues that Illinois’ RTFA should be amended as the statute lacks clarity on many aspects and consistency throughout the state’s circuit courts. Further, the statute is silent on many issues that other states have included in their Acts, such as zoning, damage caps, a statute of limitations, and management requirements. Three states––North Carolina, …

Development Of A Chitosan Nano-Immersion Vaccine Against Aeromonas Veronii Infection In Red Tilapia (Oreochromis Sp.), Pimwarang Sukkarun

Chulalongkorn University Theses and Dissertations (Chula ETD)

Red tilapia (Oreochromis sp.) is a prominent freshwater fish in Thai aquaculture. It has long been afflicted by severe bacterial diseases, ulcerative syndrome, and hemorrhagic septicemia, primarily caused by Aeromonas veronii. Vaccination is a key strategy for control and prevention. In this study a chitosan nano-immersion vaccine has been developed using a nanoemulsion technique and surface modification method with chitosan polymers. The physicochemical properties, mucoadhesive properties, immune response assays, and vaccine efficacy were investigated. The results showed that the vaccine is spherical-shaped, nanometer-sized, and having monodispersed positive charge. The mucoadhesive characterization, observed by SEM and fluorescence microscope imaging, demonstrated that …

The Expressions Of Mhc Class I And Class Ii In Biopsy Tissues By Immunohistochemistry And The Effect Of Interferon-Gamma (Ifn-Γ) On In Vitro Established Canine Cutaneous Mast Cell Tumors, Sudchaya Bhanpattanakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Canine mast cell tumors (MCT), common skin tumors in dogs, present difficulties in treatment, emphasizing the need for effective therapeutic protocols. The cancer-immunity cycle's complex interactions between cancer and the immune system play a crucial role in tumor growth. Tumors often evade immune response by downregulating MHC expression, hindering T-cell recognition. Cancer immunotherapy is a promising approach that utilizes the patient's immune system for combating cancer. Interferon-gamma (IFN-γ), a potent immune substance, plays a crucial role in enhancing MHC expression and immune functionality, crucial for T-cell recognition and cancer cell elimination. Limited research exists on MHC expression, tumor immune response, …

Upscale Production Of Canine Adipose-Derived Mesenchymal Stem Cell-Derived Exosomes For Wound Healing In Vitro, Yudith Violetta Pamulang

Chulalongkorn University Theses and Dissertations (Chula ETD)

Mesenchymal stem cell-derived exosomes (MSC-derived exosomes) have been previously reported to enhance wound healing across different phases. However, its practical application has been hindered due to challenges regarding low productivity and the lack of efficient production protocol. Additionally, the usage of exosome-based regenerative treatments in the veterinary field remains relatively unexplored. Hence, this study aimed to address these gaps by establishing a potential upscaling protocol producing canine adipose-derived mesenchymal stem cell-derived exosomes (cAD-MSC-exosomes) and exploring their wound healing potential in vitro. To facilitate production protocol establishment, an in-house exosome-collecting media, designated as VSCBIC-3, was preliminarily developed. Building upon this foundation, …

Development Of A Latex Agglutination Test Based On Vh Antibody Fragment For Detection Of Streptococcus Suis Serotype 2, Kiratika Chidkoksung

Chulalongkorn University Theses and Dissertations (Chula ETD)

Streptococcus suis serotype 2 (S. suis 2) is an important porcine pathogen that causes diseases in both swine and humans. For rapid S. suis 2 identification, a novel latex agglutination test (LAT) based on heavy-chain variable domain antibody (VH) was developed. Firstly, the soluble 47B3 VH antibody fragment from a phage display library, in which cysteine residues were engineered at the C-terminus, was expressed in Escherichia coli. The purified protein was then gently reduced to form monomeric soluble 47B3 VH subsequently used to coat with latex beads by means of site-specific conjugation. The detection sensitivity was found to be as …

A Comparison Of Crestal Bone Loss Between Healing Abutment And Customized Abutment; 6 Months Clinical Observation, Adison Jirasuwannakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Adison Jirasuwannakul : A Comparison of crestal bone loss between healing abutment and customized abutment ; 6 months clinical observation. Advisor: Associate Professor Pravej Serichetaphongse, D.D.S., M.S . Co-advisor: Asst. Prof. Wareerat Chengprapakorn,, D.D.S., Ph.D. Objective : To compare the effect on marginal bone loss between using healing abutment and customized abutment (Definite abutment). Material and method : Thirdtyfour patients who required a single posterior implant-supported prosthesis were randomly divided into two groups which were healing abutment group (Control group)and customized titanium abutment group(Test group). Patients received one dental implant between 4.0 and 5.0 mm. diameter (Dentium Superline, Dentium, Seoul, …

M2 Macrophages In Human Periapical Lesions In Relation To Histopathological Diagnosis, Clinical Features, And Lesion Volume, Supanant Visarnta

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study evaluated M1 and M2 macrophage polarization in human periapical cysts and granulomas through an immunohistochemical analysis and investigated the correlation between the macrophage polarization and histopathological diagnosis, clinical features and lesion volume using cone-beam computed tomography. The periapical biopsies histopathologically diagnosed as radicular cyst (n=52) and periapical granuloma (n=51) were analyzed by immunohistochemical method. Immuno-expressions of CD68 and CD163 were quantified. The CD68/CD163 ratio was adopted to represent M1 or M2 macrophage polarization. Pathological diagnosis, patients’ age, gender, clinical signs and symptoms, tooth location of the periapical lesion, and history of root canal treatment were obtained from treatment …

Biomarkers Of Mild Cognitive Impairment With And Without Depression In The Elderly, Gallayaporn Nantachai

Chulalongkorn University Theses and Dissertations (Chula ETD)

Amnestic Mild Cognitive Impairment (aMCI) is the deterioration of cognitive function, where those with the amnestic subtype have memory decline and may conversion to Alzheimer’s disease. This study is both a systematic review and meta-analysis on 3.798 MCI individuals and 6.063 healthy controls and a case-control study. The case-control study included 121 MCI and normal volunteers aged 60-75. Collectively, the dissertation aimed to explore the relationship between biomarkers, psychological symptoms, and neuropsychological assessment in MCI. Descriptive statistics were used to describe the general data set, while meta-statistics were used to review biomarkers. The predictive relationship of various factors in MCI …

การพัฒนากรอบแนวคิดในการประยุกต์ใช้เทคโนโลยีความเป็นจริงแบบผสมร่วมกับปัญญาประดิษฐ์เพื่อตรวจสอบคุณภาพการติดตั้งอุปกรณ์งานระบบบนแบบจำลองกรณีศึกษาผนังคอนกรีตสำเร็จรูป, จริวัฒน์ เตียวัฒนานนท์

Chulalongkorn University Theses and Dissertations (Chula ETD)

การก่อสร้างแผ่นผนังคอนกรีตสำเร็จรูปส่วนใหญ่จำเป็นต้องติดตั้งชุดงานระบบ (เครื่องกล, ไฟฟ้า, และสุขาภิบาล) ซึ่งถูกฝังภายในผนังคอนกรีตสำเร็จรูประหว่างกระบวนการผลิต ดังนั้นการติดตั้งงานระบบอย่างถูกต้องมีคุณภาพดีส่งผลให้ระบบสามารถทำงานได้อย่างมีประสิทธิภาพ อย่างไรก็ตามการติดตั้งงานระบบด้วยคนงานยังคงก่อให้เกิดปัญหาจากความไม่ชำนาญหรือประสบการณ์ของคนงานในการเลือกอุปกรณ์และตำแหน่งของการวางชิ้นงาน งานวิจัยนี้มีวัตถุประสงค์เพื่อพัฒนากรอบแนวคิดในการตรวจสอบคุณภาพของการติดตั้งชิ้นส่วนงานระบบในแผ่นผนังคอนกรีตโดยประยุกต์ใช้เทคโนโลยีปัญญาประดิษฐ์ร่วมกับเทคโนโลยีโลกเสมือนจริง ระบบตรวจสอบจะแบ่งออกเป็น 2 ส่วนหลัก คือระบบตรวจสอบชนิดของวัสดุงานระบบและระบบตรวจสอบตำแหน่งและลำดับการติดตั้งวัสดุงานระบบ โดยงานวิจัยมีขั้นตอนการพัฒนาระบบดังนี้ การปรับแต่งโมเดลปัญญาประดิษฐ์ด้วย Mask R-CNN, การประมวลผลรูปภาพด้วย Instant Segmentation, การพัฒนาระบบสำหรับปฏิบัติการบนเครื่อง Microsoft HoloLens, การพัฒนาระบบโอนถ่ายข้อมูลด้วย Restful API และทดสอบระบบการติดตั้งชิ้นส่วนงานระบบบนโมเดลกรณีศึกษา ผลวิจัยแสดงให้เห็นว่าระบบสามารถตรวจสอบการติดตั้งระบบบนโมเดลกรณีศึกษาแผ่นผนังคอนกรีตสำเร็จรูปโดยใช้เทคโนโลยีความจริงเสมือนแบบผสมร่วมกับโมเดลปัญญาประดิษฐ์ Modified Mask R-CNN โดยการทดสอบกำหนดเกณฑ์ผ่านคือ ค่าความเชื่อมั่นที่มากกว่า 80% สำหรับการตรวจสอบชนิดวัสดุ และเกณฑ์ผ่านสำหรับการตรวจสอบตำแหน่งและลำดับการติดตั้งวัสดุคือ ค่าความคล้ายกันมากกว่า 80% โดยการตรวจสอบในแต่ละขั้นตอนใช้ระยะเวลาอยู่ที่ 15-25 วินาที และมีความคลาดเคลื่อนเฉลี่ยสำหรับแสดงผลโมเดลสามมิติน้อยกว่า 0.5 เซนติเมตร

นวัตกรรมระบบตรวจสอบย้อนกลับรังนกด้วยคิวอาร์โค้ดชีวภาพ, ประภารัตน์ อัศวเนตรมณี

Chulalongkorn University Theses and Dissertations (Chula ETD)

การศึกษาในครั้งนี้มีวัตถุประสงค์เพื่อ 1) ศึกษาศักยภาพการตลาดของผลิตภัณฑ์รังนก 2) พัฒนาคิวอาร์โค้ดชีวภาพ ที่สามารถติดลงบนพื้นผิวรังนก มีความปลอดภัย สามารถตรวจสอบย้อนกลับแหล่งที่มาของรังนกด้วยการสแกนผ่านสมาร์ตโฟน และให้ผลในการตรวจสอบที่ถูกต้อง แม่นยำกว่า ซึ่งจะช่วยเพิ่มโอกาสในการขายรังนก 3) ศึกษาการยอมรับนวัตกรรมคิวอาร์โค้ดชีวภาพเพื่อระบบตรวจสอบย้อนกลับรังนก และ 4) ศึกษาความเป็นไปได้ในการนำต้นแบบคิวอาร์โค้ดชีวภาพมาใช้ประโยชน์เชิงพาณิชย์ จากการทบทวนวรรณกรรม ทำให้เกิดแนวคิดในการพัฒนา และการผลิตชุดต้นแบบระบบตรวจสอบย้อนกลับรังนกด้วยคิวอาร์โค้ดชีวภาพ ได้รับการพัฒนาโดยใช้กระบวนการ พัฒนาผลิตภัณฑ์ใหม่ (NPD) ตามขั้นตอน Stage Gate ระบบเลือกใช้ 7 เทคโนโลยีเป็นองค์ประกอบสำคัญในการพัฒนาระบบคือ เทคโนโลยีคิวอาร์โค้ด, เทคโนโลยีด้านวัสดุชีวภาพ, เทคโนโลยีการพิมพ์ Inkjet, เทคโนโลยี GPS, เว็ปเทคโนโลยีบนเครื่องข่ายอินเตอร์เน็ต, เทคโนโลยี Cloud และเทคโนโลยีสมาร์ทโฟน ทั้งหมดเพื่อผลิตเป็นระบบตรวจสอบย้อนกลับรังนกด้วยคิวอาร์โค้ดชีวภาพ ที่เพิ่มประสิทธิภาพด้านการป้องกันการปลอมแปลง และสามารถตรวจสอบย้อนกลับได้แม้รังนกไม่ถูกบรรจุในบรรจุภัณฑ์ จากแนวคิดของนวัตกรรมระบบตรวจสอบยัอนกลับรังนกด้วยคิวอาร์โค้ดชีวภาพ นำไปสู่การทดสอบการยอมรับนวัตกรรม ด้วยการวิจัยแบบผสมผสานคือ การวิจัยเชิงคุณภาพ โดยการสัมภาษณ์เชิงลึก กับกลุ่มตัวอย่างเกษตรกรฟาร์มนกแอ่น ซึ่งเป็นผู้นำเข้ารังนกสู่ห่วงโซ่อุปทานของอุตสาหกรรม และการวิจัยเชิงปริมาณด้วยการเก็บแบบสอบถามผ่านช่องทางออนไลน์ กับกลุ่มตัวอย่างผู้บริโภค ที่มีประสบการณ์ซื้อวัตถุดิบอาหารพรีเมียม ผลการวิจัยพบว่ากลุ่มตัวอย่างทั้งสอง แสดงความตั้งใจในการยอมรับนวัตกรรมระบบตรวจสอบย้อนกลับรังนกด้วยคิวอาร์โค้ดชีวภาพ การศึกษาเพื่อประเมินความเป็นไปได้ในการนำระบบตรวจสอบย้อนกลังรังนกด้วยคิวอาร์โค้ดชีวภาพ มาใช้งานเชิงพาณิชย์ โดยการประเมินด้านเทคโนโลยี การตลาด และการเงิน พบว่ามีความเหมาะสมที่ผู้ศึกษาจะนำนวัตกรรมมาใช้งานเชิงพาณิชย์ ด้วยการเลือกใช้วิธี Spin-off เพื่อทำตลาดเอง เนื่องจากผู้ถือครองนวัตกรรมมีความพร้อมในทุกด้านจากการประเมิน ทั้งนี้ระบบตรวจสอบย้อนกลับรังนกด้วยคิวอาร์โค้ดชีวภาพควรใช้วิธีการแจ้งลิขสิทธิ์ และจดทะเบียนเครื่องหมายทางการค้าเพื่อขอรับความคุ้มครองทรัพย์สินทางปัญญา จากการประเมินทางการเงินพบว่า ระยะเวลาคืนทุนของโครงการคือ 2 ปี 4 เดือนค่าปัจจุบันสุทธิ (NPV) เท่ากับ 4,914,697.73 บาท และอัตราผลตอบแทนที่แท้จริง (IRR) จากการลงทุนเท่ากับ ร้อยละ 186.8%

Blended Program And Its Impact On Knowledge, Attitude And Help-Seeking Intention Of Conflict-Related Sexual Violence Among Internally Displaced People In Northern Myanmar Camps: A Quasi-Experimental Study, Chit Pyae Pyae Han

Chulalongkorn University Theses and Dissertations (Chula ETD)

Introduction As a result of several military coups and internal armed conflicts, Myanmar has the longest history of civilian wars in the world. Human rights violations, gender-based violence, and sexual violence have become more widespread as a result of extensive conflicts and humanitarian crises. The United Nations is concerned about the detrimental consequences of sexual violence in military situations. A community-based program designed to prevent sexual violence is crucial in mitigating risk factors and enhancing protective factors Methods The two-group quasi-experimental study evaluated the impact of a community-based program to prevent sexual violence and examined the experiences of survivors among …

Role Of Grb2 Intracellular Localization In Progesterone Receptor Positive Breast Cancer, Nattamolphan Wittayavimol

Chulalongkorn University Theses and Dissertations (Chula ETD)

Progesterone receptor (PR) extranuclear signaling mediates mainly through PR polyproline domain (PPD) interaction with SH3 domain of cytoplasmic signaling molecules. PR-PPD interfered with Grb2-SOS binding through SH3 interaction resulting in decreased cell proliferation and correlates with a good prognosis in PR positive breast cancer. Grb2 is a key adaptor molecule and expressed in both nucleus and cytoplasm. We hypothesized that change in Grb2 localization alters PR transcription resulting in better clinical outcomes in PR positive breast cancer. BT-474 breast cancer cells expressing inducible Grb2-SV402x (nuclear Grb2, nuGrb2) or Grb2-MYR (membrane Grb2, memGrb2) were constructed. MemGrb2-BT-474 showed higher levels of PR …

Perception Of Academic Stress And Family Relationship On Mental Well-Being Among Pharmacy Students At Chulalongkorn University In Thailand: A Cross-Sectional Survey Study, Chompunoot Prasongpol

Chulalongkorn University Theses and Dissertations (Chula ETD)

University students' mental health and well-being have gained more global attention due to their increasing influence on health and societal issues. The cross-sectional study, conducted in May 2024 among undergraduate Chulalongkorn University pharmacy students in Thailand, aims to investigate the proportion of mental well-being levels and determine the relationship between general characteristics, perceptions of academic stress, and family relationships toward mental well-being levels among pharmacy students at Chulalongkorn University. The study used an online, self-administered questionnaire. Descriptive statistics, simple logistic regression, and multiple logistic regression models were employed for data analysis. Out of 289 pharmacy students, 199 were predominantly female …

Ultrasound-Assisted Extraction Of Cannabis Sativa And Biological Activities Assessments For Dermatological Application, Pannita Kongtananeti

Chulalongkorn University Theses and Dissertations (Chula ETD)

Cannabis sativa L. is a medicinal plant that has long been used in Thai traditional medicine and is still widely used today, with many uses in pharmaceuticals, including the treatment of skin infections. It contains a complex mixture of secondary metabolites, including cannabinoids and non-cannabinoid-type constituents, especially detla-9-tetrahydrocannabinol (THC), cannabidiol (CBD), and terpenes. However, fewer studies of cannabis have been reported regarding its anti-aging potential by investigating tyrosinase inhibition activity. In this study, ultrasound-assisted extraction (UAE) of 5 different parts of Cannabis sativa L., the determination of bioactive compounds using GC–MS/MS and the assessment of their biological properties related to …